JAX® STZ-Induced Diabetes Models
Chemically induced pancreatic necrosis to produce diabetic models.
Key benefits
- Protocol designed and tested by JAX scientists
- JAX experts handle and properly dispose of harmful streptozotocin, including byproducts found in mouse excretions
- Can be integrated with Efficacy Testing and Pathology Services
Capabilities
- Standard protocol of streptozotocin (STZ) injections is used to induce diabetes in C57BL/6J (000664, B6) males
- Customizable— female mice, other strains, different STZ doses, etc. can be used
- Injected mice periodically weighed and glucose levels measured
- Only diabetic mice with non-fasted blood glucose levels of at least 300-400 mg/dL are shipped
- Blood glucose level and body weight data for individual mice are shipped with the mice
