JAX® STZ-Induced Diabetes Models

Chemically induced pancreatic necrosis to produce diabetic models.

Key benefits

  • Protocol designed and tested by JAX scientists
  • JAX experts handle and properly dispose of harmful streptozotocin, including byproducts found in mouse excretions
  • Can be integrated with Efficacy Testing Services and histology services
  • STZ-treated immunodeficient mice are ideal preclinical models for testing human cellular therapies for diabetes. Data from NSG-STZ mice are available here


  • Standard protocol of streptozotocin (STZ) injections is used to induce diabetes in C57BL/6J (000664, B6) or NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ (005557, NSG) males
  • Customizable— other strains, different STZ doses, etc. can be used (based on JAX assessment of feasibility) 
  • Injected mice periodically weighed and glucose levels measured
  • Only diabetic mice with non-fasted blood glucose levels of at least 250 mg/dL are shipped
  • Blood glucose level and body weight data for individual mice are shipped with the mice


Related JAX® Services

Ordering information

Representatives are available
Monday - Friday:
8am-8pm ET (5am-5pm PT)

Toll free: 1-800-422-6423 (US, Canada & Puerto Rico)
or 1-207-288-5845 (from any location)
Fax: 1-207-288-6150