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The C57BL/6J strain has recently been shown to have a mutation at the NAD nucleotide transhydrogenase (Nnt) locus on mouse Chromosome 13. We have recently completed a study to determine the correlation between the Nnt allele and the resultant DIO response of B6/J and B6/NJ males. To read the article summarizing the results of this study, please complete the request form below.
In short, the results indicate that homozygosity for the Nnt mutation unique to B6/J males does not diminish their responsiveness to a 60% kcal fat diet when compared to Nnt-intact B6/NJ males, and may actually contribute to the more rapid development of adiposity and the greater impairment of glucose tolerance. However, we cannot conclude that the mutant B6/J Nnt allele is the factor responsible for the more robust DIO response because certain strains that are even more DIO-responsive than B6/J, such as NON/ShiLtJ, are Nnt wild-type. Likewise, strains such as A/J that are DIO-resistant are also Nnt wild-type.
The C57BL/6J strain has a unique place in the scientific community, as it is one of the most well characterized mouse strains and is the strain used to define the reference mouse genome sequence, a critical resource for comparison to the Human Genome. Discovery of the Nnt mutation was made possible by the extensive study of C57BL/6J mice.
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