Cardiovascular

The Jackson Laboratory offers approximately 250 different strains for cardiovascular biology research. Visit lists of JAX® Mice for cardiovascular research:

Visit pages of additional resources for cardiovascular research:


Mouse Heart, Lung, Blood, and Sleep Disorders Center

The goal of the Mouse Heart, Lung, Blood, and Sleep Disorders (HLBS) Center at The Jackson Laboratory is to link genetic variation to biological function and dysfunction.

Learn more at the HLBS Web site.  



Mouse Phenome Database

The Mouse Phenome Database is a collection of baseline phenotypic data on commonly used and genetically diverse inbred mouse strains through a coordinated international effort.

Visit the Mouse Phenome Database.


CardioGenomics

This Web site is a National Heart, Lung and Blood Institute sponsored program for genomic applications.

Learn more at the CardioGenomics Web site. 


Cardiovascular Research at The Jackson Laboratory


Select Publications Authored by Jackson Laboratory Scientists

(authors in bold indicate Jackson Laboratory scientists)

  • Lyons MA, Korstanje R, Li R, Walsh KA, Churchill GA, Carey MC, Paigen B. Genetic contributors to lipoprotein cholesterol levels in an intercross of 129S1/SvImJ and RIIIS;/J inbred mice. Physiol Genomics 2004; 17:114-121. 
  • Schuldt AJT, Hampton TJ, Chu V, Vogler CA, Galvin N, Lessard MD, Barker JE. Electrocardiographic and other cardiac anomalies in b-glucuronidase-null mice corrected by nonablative neonatal marrow transplantation. Proc Natl Acad Sci U S A 2004 Jan 13; 101(2):603-608.
  • Maddatu TP, Garvey SM, Schroeder DG, Hampton TG, Cox GA. Transgenic rescue of neurogenic atrophy in the nmd mouse reveals a role for lghmbp2 in dilated cardiomyopathy. Hum Molec Genet 2004; 13(11):1105-1115. 

  • Svenson KL, O'Brien TP, Meyers KA, Barker JE, Peters LL. Center for Mouse Models of Heart, Lung and Blood Disorders/NHLBI PGA, The Jackson Laboratory, Bar Harbor, ME, USA. 200_. A high-throughput mutagenesis screen identifies robust new mouse models of cardiovascular disease. Circulation, (in press).
  • Phelan SA, Beier DR, Higgins DC, Paigen B.  Confirmation and high resolution mapping of an atherosclerosis susceptibility gene in mice on Chromosome 1.  Mamm Genome 2002 Oct; 13:548-53.
  • Wang X, Paigen B.  Comparative genetics of atherosclerosis and restenosis: exploration with mouse models.  Arterioscler Thromb Vasc Biol 2002 Jun 1; 22:884-6.
  • Lyons MA, Wittenburg H, Li R, Walsh KA, Churchill GA, Carey MC, Paigen B. Quantitative trait loci that determine lipoprotein cholesterol levels in DBA/2J and CASTE/Ei inbred mice. J Lipid Res 2003 44:953-967.

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