JAX® Mice for metabolic disease research
The comparison tables below summarize metabolic disease phenotypes for eight selected, well characterized or emerging JAX® Mice models that together comprise a robust tool set for basic research and therapeutic screening. For additional information about these models, visit their strain data sheets or download our metabolic models flier (.pdf)
Obesity phenotypes table also available
Diabetes phenotypes
| Humans | B6.V-Lepob/J (000632) |
BKS.Cg-Dock7m +/+ Leprdb/J (000642) |
B6.BKS(D)- Leprdb/J (000697) |
C57BL/6J (000664) | |
|---|---|---|---|---|---|
| Induced or spontaneous | Spontaneous | Spontaneous | Spontaneous | Spontaneous | Diet-induced |
| Genetics | Polygenic | Polygenic | Polygenic | Polygenic | Polygenic |
| Onset | Mature (progressive) | Young | Young | Young | Mature |
| Sex | M, F | M, F | M, F | M, F | M |
| Hyperinsulinemia | Moderate | Severe | Severe | Severe | Mild |
| Glucose intolerance | Yes | Yes | Yes | Yes | Yes |
| Hyperglycemia | Yes | Moderate (transient) | Severe | Severe | Moderate |
| Islet atrophy | Variable | No | Yes | Hyperplasia | No |
| Humans | KK.Cg-Ay/J (002468) |
NONcNZO10/LtJ (004456) |
NON/ShiLtJ (002423) |
TALLYHO/JngJ (005314) | |
|---|---|---|---|---|---|
| Induced or spontaneous | Spontaneous | Spontaneous | Spontaneous | Diet-induced | Spontaneous |
| Genetics | Polygenic | Polygenic | Polygenic | Polygenic | Polygenic |
| Onset | Mature (progressive) | Mature | Mature | Mature | Mature |
| Sex | M, F | M, F | M, F | M | M |
| Hyperinsulinemia | Moderate | Moderate | Moderate | No | Yes |
| Glucose intolerance | Yes | Yes | Yes | High | Yes |
| Hyperglycemia | Yes | Severe | Severe | Moderate | Males only |
| Islet atrophy | Variable | Yes | Yes | No | Hypertrophy/later atrophy |
