JAX® Mice for metabolic disease research
The comparison tables below summarize metabolic disease phenotypes for eight selected, well characterized or emerging JAX® Mice models that together comprise a robust tool set for basic research and therapeutic screening. For additional information about these models, visit their strain data sheets or download our metabolic models flier (.pdf)
Diabetes phenotypes table also available
Obesity phenotypes
| Humans | B6.V-Lepob/J (000632) |
BKS.Cg-Dock7m +/+ Leprdb/J (000642) |
B6.BKS(D)- Leprdb/J (000697) |
C57BL/6J (000664) | |
|---|---|---|---|---|---|
| Induced or spontaneous | Spontaneous | Spontaneous | Spontaneous | Spontaneous | Diet-induced |
| Genetics | Polygenic | Monogenic | Monogenic | Monogenic | Polygenic |
| Onset | Variable | Young | Young | Young | Mature |
| Sex | M, F | M | M | M | M |
| Degree | Moderate | Severe | Severe | Severe | Severe |
| Hypertriglyceridemia | Yes | Yes | Yes | Yes | Mild |
| Leptin/leptin receptor axis | Normal | Disrupted | Disrupted | Disrupted | Normal |
| Hyperphagia | No | Yes | Yes | Yes | Mild |
| Hypercorticism | No | Yes | Yes | Yes | No |
| Thermoregulatory defects | No | Yes | Yes | Yes | ND |
| Liver steatosis | Variable | Severe | Severe | Severe | ND |
ND = no data
| Humans | KK.Cg-Ay/J (002468) |
NONcNZO10/LtJ (004456) |
NON/ShiLtJ (002423) |
TALLYHO/JngJ (005314) | |
|---|---|---|---|---|---|
| Induced or spontaneous | Spontaneous | Spontaneous | Spontaneous | Diet-induced | Spontaneous |
| Genetics | Polygenic | Monogenic | Polygenic | Polygenic | Polygenic |
| Onset | Variable | Mature | Mature | Mature | Young |
| Sex | M, F | M, F | M | M | M, F |
| Degree | Moderate | Moderate | Moderate | Severe | Moderate |
| Hypertriglyceridemia | Yes | Yes | Yes | Moderate | Yes |
| Leptin/leptin receptor axis | Normal | Normal | Normal | Normal | Hyperleptinemic |
| Hyperphagia | No | Yes | No | No | No |
| Hypercorticism | No | No | No | ND | ND |
| Thermoregulatory defects | No | ND | No | ND | No |
| Liver steatosis | Variable | Moderate | Moderate | Severe | Moderate |
ND = no data
