References for the NSG mouse
Immunity
Hematopoietic stem cell engraftment / peripheral blood grafts / humanized mice
André MC; Erbacher A; Gille C; Schmauke V; Goecke B; Hohberger A; Mang P; Wilhelm A; Mueller I; Herr W; Lang P; Handgretinger R; Hartwig UF. 2010. Long-Term Human CD34+ Stem Cell-Engrafted Nonobese Diabetic/SCID/IL-2 gamma-null Mice Show Impaired CD8+ T Cell Maintenance and a Functional Arrest of Immature NK Cells. J Immunol Sep 1;185(5):2710-20. [PubMed: 20668220]
Billerbeck E; Barry WT; Mu K; Dorner M; Rice CM; Ploss A. 2011. Development of human CD4+FoxP3+ regulatory T cells in human stem cell factor, GM-CSF and interleukin 3 expressing NOD SCID IL2R{gamma}NULL humanized mice. Blood Mar 17;117(11):3076-86. [PubMed: 21252091]
Boitano AE; Wang J; Romeo R; Bouchez LC; Parker AE; Sutton SE; Walker JR; Flaveny CA; Perdew GH; Denison MS; Schultz PG; Cooke MP. 2010. Aryl Hydrocarbon Receptor Antagonists Promote the Expansion of Human Hematopoietic Stem Cells. Science Sep 10;329(5997):1345-58. [PubMed: 20688981]
Broxmeyer HE; Lee MR; Hangoc G; Cooper S; Prasain N; Kim YJ; Mallett C; Ye Z; Witting S; Cornetta K; Cheng L; Yoder MC. 2011. Hematopoietic stem/progenitor cells; generation of induced pluripotent stem cells; and isolation of endothelial progenitors from 21-23.5 year cryopreserved cord blood. Blood May 5;117(18):4773-7. [PubMed: 21393480]
Bueno C; Montes R; de la Cueva T; Gutierrez-Aránda I; Menendez P. 2010. Intra-bone marrow transplantation of human CD34(+) cells into NOD/LtSz-scid IL-2rgamma(null) mice permits multilineage engraftment without previous irradiation. Cytotherapy 12(1):45-9. [PubMed: 19929453]
Chen Q; Khoury M; Chen J. 2009. Expression of human cytokines dramatically improves reconstitution of specific human-blood lineage cells in humanized mice. Proc Natl Acad Sci U S A Dec 22;106(51):21783-8. [PubMed: 19966223]
Choi B; Chun E; Kim M; Kim ST; Yoon K; Lee KY; Kim SJ. 2010. Human B Cell Development and Antibody Production in Humanized NOD/SCID/IL-2Rγ(null) (NSG) Mice Conditioned by Busulfan. J Clin Immunol 2010 Oct 28. [Epub head of print] [PubMed: 20981478]
Drake AC; Khoury M; Leskov I; Iliopoulou BP; Fragoso M; Lodish H; Chen J. 2011. Human CD34+ CD133+ Hematopoietic Stem Cells Cultured with Growth Factors Including Angptl5 Efficiently Engraft Adult NOD-SCID Il2rPLoS One. Apr 29;6(4):e18382. [PubMed: 21559522]
Doulatov S; Notta F; Eppert K; Nguyen LT; Ohashi PS; Dick JE. 2010. Revised map of the human progenitor hierarchy shows the origin of macrophages and dendritic cells in early lymphoid development. Nat Immunol Jul;11(7):585-93. [PubMed: 20543838]
Eldjerou LK; Chaudhury S; Baisre-de Leon A; He M; Arcila ME; Heller G; O'Reilly RJ; Barker JN; Moore MA. 2010. An in vivo model of double unit cord blood transplantation that correlates with clinical engraftment. Blood Nov 11;116(19):3999-4006. [PubMed: 20587781]
Ghinassi B; Ferro L; Masiello F; Tirelli V; Sanchez M; Migliaccio G; Whitsett C; Kachala S; Riviere I; Saledain M; Migliaccio AR. 2011. Recovery and Biodistribution of Ex Vivo Expanded Human Erythroblasts Injected into NOD/SCID/IL2Rg(null) MiceStem Cells International. Volume (2011), Article ID 673752.
Giassi LJ; Pearson T; Shultz LD; Laning J; Biber K; Kraus M; Woda BA; Schmidt MR; Woodland RT; Rossini AA; Greiner DL. 2008. Expanded CD34+ human umbilical cord blood cells generate multiple lymphohematopoietic lineages in NOD-scid IL2rgamma(null) mice. Exp Biol Med (Maywood) 233(8):997-1012. [PubMed: 18653783]
Harui A; Kiertscher SM; Roth MD. 2010. Reconstitution of huPBL-NSG Mice with Donor-Matched Dendritic Cells Enables Antigen-Specific T cell Activation. J Neuroimmune Pharmacol Mar;6(1):148-57. [PubMed: 20532647]
Hayakawa J; Hsieh MM; Anderson DE; Phang O; Uchida N; Washington K; Tisdale JF. 2010. The assessment of human erythroid output in NOD/SCID mice reconstituted with human hematopoietic stem cells. Cell Transplant Jun 29. [Epub ahead of print] [PubMed: 20587140]
Hayakawa J; Hsieh MM; Uchida N; Phang O; Tisdale JF. 2009. Busulfan produces efficient human cell engraftment in NOD/LtSz-Scid IL2Rgamma(null) mice. Stem Cells 27(1):175-82. [PubMed: 18927475]
Ishikawa F; Niiro H; Iino T; Yoshida S; Saito N; Onohara S; Miyamoto T; Minagawa H; Fujii S; Shultz LD; Harada M; Akashi K. 2007. The developmental program of human dendritic cells is operated independently of conventional myeloid and lymphoid pathways. Blood 110(10):3591-660. [PubMed: 17664352]
Ishikawa F; Shimazu H; Shultz LD; Fukata M; Nakamura R; Lyons B; Shimoda K; Shimoda S; Kanemaru T; Nakamura K; Ito H; Kaji Y; Perry AC; Harada M. 2006. Purified human hematopoietic stem cells contribute to the generation of cardiomyocytes through cell fusion. FASEB J 20(7):950-2. [PubMed: 16585061]
Ishikawa F; Yasukawa M; Lyons B; Yoshida S; Miyamoto T; Yoshimoto G; Watanabe T; Akashi K; Shultz LD; Harada M. 2005. Development of functional human blood and immune systems in NOD/SCID/IL2 receptor {gamma} chain(null) mice. Blood 106(5):1565-73. [PubMed: 15920010]
Kim KD; Srikanth S; Yee MK; Mock DC; Lawson GW; Gwack Y. 2011. ORAI1 Deficiency Impairs Activated T Cell Death and Enhances T Cell Survival. J Immunol. Aug 26. [Epub ahead of print] [PubMed: 21873530]
Larochelle A; Savona M; Wiggins M; Anderson S; Ichwan B; Keyvanfar K; Morrison SJ; Dunbar CE. 2011. Human and rhesus macaque hematopoietic stem cells cannot be purified based only upon SLAM family markers. Blood Feb 3;117(5):1550-4. [PubMed: 21163926]
Li L; Modi H; McDonald T; Rossi J; Yee JK; Bhatia R. 2011. A critical role for SHP2 in STAT5 activation and growth factor mediated proliferation; survival and differentiation of human CD34+ cells. Blood. Aug 11;118(6):1504-15. [PubMed: 21670473]
Liu C; Chen BJ; Deoliveira D; Sempowski GD; Chao NJ; Storms RW. 2010. Progenitor cell dose determines the pace and completeness of engraftment in a xenograft model for cord blood transplantation. Blood Dec 16;116(25):5518-27. [PubMed: 20833978]
Lockridge JL; Chen X; Zhou Y; Rajesh D; Roenneburg DA; Hegde S; Gerdts S; Cheng TY; Anderson RJ; Painter GF; Moody DB; Burlingham WJ; Gumperz JE. 2011. Analysis of the CD1 Antigen Presenting System in Humanized SCID Mice. PLoS One. 6(6):e21701. [PubMed: 21738769]
Luther C; Warner K; Takei F. 2011. Unique progenitors in mouse lymph node develop into CD127+ NK cells: thymus-dependent and thymus-independent pathways. Blood Apr 14;117(15):4012-21. [PubMed: 21355093]
Majeti R; Park CY; Weissman IL. 2007. Identification of a hierarchy of multipotent hematopoietic progenitors in human cord blood. Cell Stem Cell 1(6):635-45. [PubMed: 18371405]
Marodon G; Desjardins D; Mercey L; Baillou C; Parent P; Manuel M; Caux C; Bellier B; Pasqual N; Klatzmann D; 2009. High diversity of the immune repertoire in humanized NOD.SCID.gammac(-/-) mice. Eur J Immunol Aug;39(8):2136-45 [PubMed: 19572320]
Notta F, Doulatov S, Dick JE. 2010. Engraftment of human hematopoietic stem cells is more efficient in female NOD/SCID/IL-2Rgcnull recipients. Blood May 115(18): 3704-7 [PubMed: 20207983]
Notta F; Mullighan CG; Wang JC; Poeppl A; Doulatov S; Phillips LA; Ma J; Minden MD; Downing JR; Dick JE. 2011. Evolution of human BCR-ABL1 lymphoblastic leukaemia-initiating cells. Nature 2011 Jan 20;469(7330):362-7. [PubMed: 21248843]
Parcelier A; Maharzi N; Delord M; Robledo-Sarmiento M; Nelson E; Belakhdar-Mekid H; Pla M; Kuranda K; Parietti V; Goodhardt M; Legrand N; Bernstein ID; Gluckman JC; Sigaux F; Canque B. 2011. AF1q/MLLT11 regulates the emergence of human prothymocytes through cooperative interaction with the Notch signaling pathway. Blood. Aug 18;118(7):1784-96 [PubMed: 21715312]
Rajesh D; Zhou Y; Jankowska-Gan E; Renneburg DA; Dart ML; Torrealba J; Burlingham WJ. 2010. Th1 and Th17 immunocompetence in humanized NOD/SCID/IL2rg(null) mice. Hum Immunol Jun;71(6):551-9. [PubMed: 20298731]
Rohrabaugh SL; Campbell TB; Hangoc G; Broxmeyer HE. 2011. Ex vivo rapamycin treatment of human cord blood CD34(+) cells enhances their engraftment of NSG mice. Blood Cells Mol Dis Apr 15;46(4):318-20. [PubMed: 21411351]
Shin JW; Swift J; Spinler KR; Discher DE. 2011. Myosin-II inhibition and soft 2D matrix maximize multinucleation and cellular projections typical of platelet-producing megakaryocytes. Proc Natl Acad Sci U S A. Jul 12;108(28):11458-63. [PubMed: 21709232]
Shultz LD; Saito Y; Najima Y; Tanaka S; Ochi T; Tomizawa M; Doi T; Sone A; Suzuki N; Fujiwara H; Yasukawa M; Ishikawa F. 2010. Generation of functional human T-cell subsets with HLA-restricted immune responses in HLA class I expressing NOD/SCID/IL2r gamma-null humanized mice. Proc Natl Acad Sci U S A Jul 20;107(29):13022-7. [PubMed: 20615947]
Strowig T; Chijioke O; Carrega P; Arrey F; Meixlsperger S; Rämer PC; Ferlazzo G; Münz C. 2010. Human NK cells of mice with reconstituted human immune system components require pre-activation to acquire functional competence. Blood 2010 Nov 18;116(20):4158-67 [PubMed: 20671122]
Tormin A; Li O; Brune JC; Walsh S; SchŸtz B; Ehinger M; Ditzel N; Kassem M; Scheding S. 2011. CD146 expression on primary non-hematopoietic bone marrow stem cells correlates to in situ localization. Blood 2011 Mar 17. [Epub ahead of print] [PubMed: 21415267]
Zou J; Sweeney CL; Chou BK; Choi U; Pan J; Wang H; Dowey SN; Cheng L; Malech HL. Oxidase deficient neutrophils from X-linked chronic granulomatous disease iPS cells: functional correction by zinc finger nuclease mediated safe harbor targeting. Blood 2011 Mar 16. [Epub ahead of print] [PubMed: 21411759]
NSG as a superior host for human immune system components
Brehm MA; Cuthbert A; Yang C; Miller DM; DiIorio P; Laning J; Burzenski L; Gott B; Foreman O; Kavirayani A; Herlihy M; Rossini AA; Shultz LD; Greiner DL.. 2010. Parameters for establishing humanized mouse models to study human immunity: analysis of human hematopoietic stem cell engraftment in three immunodeficient strains of mice bearing the IL2rgamma(null) mutation. Clin Immunol Apr;135(1):84-98. [PubMed: 20096637]
Lepus CM; Gibson TF; Gerber SA; Kawikova I; Szczepanik M; Ablamunits V; Kirkiles-Smith N; Herold KC; Bothwell AL; Pober JS; Harding MJ. 2009. Comparison of Human Fetal Liver, Umbilical Cord Blood, and Adult Blood Hematopoietic Stem Cell Engraftment in NOD-scid/gammac-/-, Balb/c-Rag2-/-gammac-/-, and C.B-17-scid/bg Immunodeficient Mice. Hum Immunol Oct;70(10):790-802. [PubMed: 19524633]
McDermott SP; Eppert K; Lechman E; Doedens M; Dick JE. 2010. Comparison of human cord blood engraftment between immunocompromised mouse strains. Blood Jul 15;116(2):193-200 [PubMed: 20404133]
Shultz LD; Lyons BL; Burzenski LM; Gott B; Chen X; Chaleff S; Kotb M; Gillies SD; King M; Mangada J; Greiner DL; Handgretinger R. 2005. Human lymphoid and myeloid cell development in NOD/LtSz-scid IL2R gamma null mice engrafted with mobilized human hemopoietic stem cells. J Immunol 174(10):6477-89. [PubMed: 15879151]
Transplantation research (graft-versus-host disease)
Bohana-Kashtan O; Morisot S; Hildreth R; Brayton C; Levitsky HI; Civin CI. 2009. Selective reduction of graft-versus-host disease-mediating human T cells by ex vivo treatment with soluble Fas ligand. J Immunol Jul 1;183(1):696-705. [PubMed: 19535642]
Hemmerling J; Wegner-Kops J; von Stebut E; Wolff D; Wagner EM; Hartwig UF; André MC; Theobald M; Schopf RE; Herr W; Meyer RG. 2011. Human Epidermal Langerhans Cells Replenish Skin Xenografts and Are Depleted by Alloreactive T Cells In Vivo. J Immunol. Aug 1;187(3):1142-9. [PubMed ID: 21697461]
King MA; Covassin L; Brehm MA; Racki W; Pearson T; Leif J; Laning J; Fodor W; Foreman O; Burzenski L; Chase TH; Gott B; Rossini AA; Bortell R; Shultz LD; Greiner DL. 2009. Human peripheral blood leucocyte non-obese diabetic-severe combined immunodeficiency interleukin-2 receptor gamma chain gene mouse model of xenogeneic graft-versus-host-like disease and the role of host major histocompatibility complex. Clin Exp Immunol 2009 Jul;157(1):104-18. [PubMed: 19659776]
Kirkiles-Smith NC; Harding MJ; Shepherd BR; Fader SA; Yi T; Wang Y; McNiff JM; Snyder EL; Lorber MI; Tellides G; Pober JS. 2010. Development of a humanized mouse model to study the role of macrophages in allograft injury. Transplantation Jan 27;87(2):189-97. [PubMed: 19155972]
Pino S; Brehm MA; Covassin-Barberis L; King M; Gott B; Chase TH; Wagner J; Burzenski L; Foreman O; Greiner DL; Shultz LD. 2010. Development of Novel Major Histocompatibility Complex Class I and Class II-Deficient NOD-SCID IL2R Gamma Chain Knockout Mice for Modeling Human Xenogeneic Graft-Versus-Host Disease. Methods Mol Biol 602:105-17. [PubMed: 20012395]
Racki WJ; Covassin L; Brehm M; Pino S; Ignotz R; Dunn R; Laning J; Graves SK; Rossini AA; Shultz LD; Greiner DL. 2010 NOD-scid IL2rgamma(null) mouse model of human skin transplantation and allograft rejection. Transplantation Mar 15;89(5):527-36. [PubMed: 20134397]
Vlad G; Stokes MB; Liu Z; Chang CC; Sondermeijer H; Vasilescu ER; Colovai AI; Berloco P; D'Agati VD; Ratner L; Cortesini R; Suciu-Foca N. 2009. Suppression of xenogeneic graft-versus-host disease by treatment with immunoglobulin-like transcript 3-Fc. Hum Immunol 2009. Sep;70(9):663-9. PubMed: 19501624]
Reviews and protocols
Shultz LD; Ishikawa F; Greiner DL. 2007. Humanized mice in translational biomedical research. Nat Rev Immunol 7(2):118-30. [PubMed: 17259968]
Ishikawa F; Saito Y; Yoshida S; Harada M; Shultz LD. 2008. The differentiative and regenerative properties of human hematopoietic stem/progenitor cells in NOD-SCID/IL2rgamma(null) mice. Curr Top Microbiol Immunol 324:87-94. [PubMed: 18481454]
Pearson T; Greiner DL; Shultz LD. 2008. Creation of "humanized" mice to study human immunity. Curr Protoc Immunol 2008 May;Chapter 15:Unit 15.21. [PubMed: 18491294]
Infectious disease
As a model for malaria infection
Arnold L; Tyagi RK; Meija P; Swetman C; Gleeson J; Pérignon JL; Druilhe P. 2011 Further Improvements of the P. falciparum Humanized Mouse Model. PLoS ONE Mar 31;6(3):e18045. [PubMed: 21483851]
Jiménez-Díaz MB; Mulet T; Viera S; Gómez V; Garuti H; Ibáñez J; Alvarez-Doval A; Shultz LD; Martínez A; Gargallo-Viola D; Angulo-Barturen I. 2009. Improved murine model of malaria using P. falciparum competent strains and non-myelodepleted NOD-scid IL2R{gamma}null mice engrafted with human erythrocytes. Antimicrob Agents Chemother Oct;53(10):4533-6 [PubMed: 19596869]
Cytomegalovirus
Smith MS; Goldman DC; Bailey AS; Pfaffle DL; Kreklywich CN; Spencer DB; Othieno FA; Streblow DN; Garcia JV; Fleming WH; Nelson JA. 2010. Granulocyte-colony stimulating factor reactivates human cytomegalovirus in a latently infected humanized mouse model. Cell Host Microbe Sep 16;8(3):284-91. [PubMed: 20833379]
Dengue virus
Jaiswal S; Pearson T; Friberg H; Shultz LD; Greiner DL; Rothman A; Mathew A. 2009. Dengue virus infection and virus-specific HLA-A2 restricted immune responses in humanized NOD-scid IL2rgammanull mice. PLoS One 2009 Oct 5;4(10):e7251. [PubMed: 19802382]
Mota J; Rico-Hesse R. 2009. Humanized mice show clinical signs of dengue fever according to infecting virus genotype. J Virol Sep;83(17):8638-45. [PubMed: 19535452]
Subramanya S; Kim SS; Abraham S; Yao J; Kumar M; Kumar P; Haridas V; Lee SK; Shultz L; Greiner D; N M; Shankar P. 2009. Targeted delivery of siRNA to human dendritic cells to suppress Dengue viral infection and associated proinflammatory cytokine production. J Virol Mar;84(5):2490-501. [PubMed: 20015996]
Ma SD; Hegde S; Young KH; Sullivan R; Rajesh D; Zhou Y; Jankowska-Gan E; Burlingham WJ; Sun X; Gulley ML; Tang W; Gumperz JE; Kenney SC. 2011. A new model of EBV infection reveals an important role for early lytic viral protein expression in the development of lymphomas. J Virol Jan;85(1):165-77 [PubMed: 20980506]
Humanized model to study Epstein Barr virus
Strowig T; Gurer C; Ploss A; Liu YF; Arrey F; Sashihara J; Koo G; Rice CM; Young JW; Chadburn A; Cohen JI; Münz C. 2009. Priming of protective T cell responses against virus-induced tumors in mice with human immune system components. J Exp Med Jun 8;206(6):1423-34. [PubMed: 19487422]
HIV modeling and therapeutics
Dash PK; Gorantla S; Gendelman HE; Knibbe J; Casale GP; Makarov E; Epstein AA; Gelbard HA; Boska MD; Poluektova LY. 2011. Loss of Neuronal Integrity during Progressive HIV-1 Infection of Humanized Mice. J Neurosci Mar 2;31(9):3148-57. [PubMed: 21368026]
Garg H; Joshi A; Ye C; Shankar P; Manjunath N. 2011. Single amino acid change in gp41 region of HIV-1 alters bystander apoptosis and CD4 decline in humanized mice. Virol J Jan 21;8(1):34. [PubMed: 21255440]
Olesen R; Wahl A; Denton PW; Victor Garcia J. 2011. Immune reconstitution of the female reproductive tract of humanized BLT mice and their susceptibility to human immunodeficiency virus infection. J Reprod Immunol Mar;88(2):195-203. [PubMed: 21256601]
Sato K; Koyanagi Y. The mouse is out of the bag: insights and perspectives on HIV-1-infected humanized mouse models. Exp Biol Med (Maywood). Aug 1;236(8):977-85. [PubMed: 21750016]
Wilen CB; Wang J; Tilton JC; Miller JC; Kim KA; Rebar EJ; Sherrill-Mix SA; Patro SC; Secreto AJ; Jordan AP; Lee G; Kahn J; Aye PP; Bunnell BA; Lackner AA; Hoxie JA; Danet-Desnoyers GA; Bushman FD; Riley JL; Gregory PD; June CH; Holmes MC; Doms RW. 2011. HIV-Resistant Human CD4+ T Cells with CXCR4-Specific Zinc-Finger Nucleases. PLoS Pathog Apr;7(4):e1002020. [PubMed: 21533216]
HIV therapeutics
Denton PW; Krisko JF; Powell DA; Mathias M; Kwak YT; Martinez-Torres F; Zou W; Payne DA; Estes JD; Garcia JV. 2010. Systemic administration of antiretrovirals prior to exposure prevents rectal and intravenous HIV-1 transmission in humanized BLT mice. PLoS One Jan 21;5(1):e8829. [PubMed: 20098623]
Gorantla S; Makarov E; Finke-Dwyer J; Gebhart CL; Domm W; Dewhurst S; Gendelman HE; Poluektova LY. 2010. CD8+ Cell Depletion Accelerates HIV-1 Immunopathology in Humanized Mice. J Immunol Jun 15 184(12):7082-91. [PubMed: 20495069]
Holt N; Wang J; Kim K; Friedman G; Wang X; Taupin V; Crooks GM; Kohn DB; Gregory PD; Holmes MC; Cannon PM. 2010. Human hematopoietic stem/progenitor cells modified by zinc-finger nucleases targeted to CCR5 control HIV-1 in vivo. Nat Biotechnol Aug;28(8):839-47 [PubMed: 20601939]
Joseph A, Zheng JH, Chen K, Dutta M, Chen C, Stiegler G, Kunert R, Follenzi A, Goldstein H. 2010. Inhibition of In Vivo HIV Infection In Humanized Mice By Gene Therapy of Human Hematopoietic Stem Cells with a Lentiviral Vector Encoding a Broadly Neutralizing Anti-HIV Antibody. J Virol Jul;84(13):6645-53. [PubMed: 20410262]
Kumar P; Ban HS; Kim SS; Wu H; Pearson T; Greiner DL; Laouar A; Yao J; Haridas V; Habiro K; Yang YG; Jeong JH; Lee KY; Kim YH; Kim SW; Peipp M; Fey GH; Manjunath N; Shultz LD; Lee SK; Shankar P. 2008. T cell-specific siRNA delivery suppresses HIV-1 infection in humanized mice. Cell 134(4):577-86. [PubMed: 18691745]
Gorantla S; Makarov E; Finke-Dwyer J; Castanedo A; Holguin A; Gebhart CL; Gendelman HE; Poluektova L. 2010. Links between Progressive HIV-1 Infection of Humanized Mice and Viral Neuropathogenesis. Am J Pathol Dec;177(6):2938-49 [PubMed: 21088215]
Mukherjee R; Plesa G; Sherrill-Mix S; Richardson MW; Riley JL; Bushman FD. 2010. HIV sequence variation associated with env antisense adoptive T-cell therapy in the hNSG mouse model. Mol Ther Apr;18(4):803-11. [PubMed: 20104212]
Measles
Boussaad I; Varagnolo L; Hornich V; Rieger L; Krockenberger M; Stuehmer T; Kranzfelder D; Mueller AM; Schneider-Schaulies S. 2011. Wild-type Measles Virus (MV) interferes with short term engraftment of human CD34+ hematopoietic progenitor cells. J Virol. Aug;85(15):7710-8 [PubMed: 21593150]
Sepsis model
Unsinger J, McDonough JS, Shultz LD, Ferguson TA, Hotchkiss RS. 2009. Sepsis-induced human lymphocyte apoptosis and cytokine production in "humanized" mice. J Leukoc Biol Aug;86(2):219-27. [PubMed: 19369639]
Typhoid fever
Libby SJ; Brehm MA; Greiner DL; Shultz LD; McClelland M; Smith KD; Cookson BT; Karlinsey JE; Kinkel TL; Porwollik S; Canals R; Cummings LA; Fang FC. 2010. Humanized nonobese diabetic-scid IL2r{gamma}null mice are susceptible to lethal Salmonella Typhi infection. Proc Natl Acad Sci U S A Aug 31;107(35):15589-94. [PubMed: 20713716]
Varicella-zoster virus
Rowe J; Greenblatt RJ; Liu D; Moffat JF. 2010. Compounds that target host cell proteins prevent varicella-zoster virus replication in culture, ex vivo, and in SCID-Hu mice. Antiviral Res Jun;86(3):276-85. [PubMed: 20307580]
Cancer
Blastic NK cell lymphoma / blastic plasmacytoid dendritic cell neoplasm (BNKL)
Agliano A; Martin-Padura I; Marighetti P; Calleri A; Prior C; Redrado M; Calvo A; Bertolini F. 2011. Therapeutic effect of Lenalidomide in a novel xenograft mouse model of human Blastic NK cell lymphoma/blastic plasmacytoid dendritic cell neoplasm. Clin Cancer Res. Aug 19. [Epub ahead of print] [PubMed: 21856771]
Breast cancer
Prud'homme GJ; Glinka Y; Toulina A; Ace O; Subramaniam V; Jothy S. 2010 Breast Cancer Stem-Like Cells Are Inhibited by a Non-Toxic Aryl Hydrocarbon Receptor Agonist. PLoS ONE 5(11): e13831. [PubMed: 21072210]
Cancer stem cells
Ishizawa K; Rasheed ZA; Karisch R; Wang Q; Kowalski J; Susky E; Pereira K; Karamboulas C; Moghal N; Rajeshkumar NV; Hidalgo M; Tsao M; Ailles L; Waddell TK; Maitra A; Neel BG; Matsui W. 2010. Tumor-Initiating Cells Are Rare in Many Human Tumors. Cell Stem Cell Sep 3;7(3):279-282. [PubMed: 20804964]
Liu H; Patel MR; Prescher JA; Patsialou A; Qian D; Lin J; Wen S; Chang YF; Bachmann MH; Shimono Y; Dalerba P; Adorno M; Lobo N; Bueno J; Dirbas FM; Goswami S; Somlo G; Condeelis J; Contag CH; Gambhir SS; Clarke MF. 2010. Cancer stem cells from human breast tumors are involved in spontaneous metastases in orthotopic mouse models. Proc Natl Acad Sci U S A Oct 19;107(42):18115-20 [PubMed: 20921380]
Scaffidi P; Misteli T. 2011. In vitro generation of human cells with cancer stem cell properties. Nat Cell Biol. Aug 21;13(9):1051-61. [PubMed ID: 21857669]
Silvestre DC; Pineda Marti JR; Hoffschir F; Studler JM; Mouthon MA; Pflumio F; Junier MP; Chneiweiss H; Boussin FD. Alternative Lengthening of Telomeres in Human Glioma Stem Cells. Stem Cells 2011 Jan 14. [Epub ahead of print] [PubMed: 21240944]
Thirant C, Bessette B, Varlet P, Puget S, Cadusseau J, Tavares Sdos R, Studler JM, Silvestre DC, Susini A, Villa C, Miquel C, Bogeas A, Surena AL, Dias-Morais A, Léonard N, Pflumio F, Bieche I, Boussin FD, Sainte-Rose C, Grill J, Daumas-Duport C, Chneiweiss H, Junier MP. 2011. Clinical Relevance of Tumor Cells with Stem-Like Properties in Pediatric Brain Tumors. PLoS One 2011 Jan 28;6(1):e16375. [PubMed: 21297991]
Esophageal cancer
Predina JD; Judy B; Aliperti LA; Fridlender ZG; Blouin A; Kapoor V; Laguna B; Nakagawa H; Rustgi AK; Aguilar L; Aguilar-Cordova E; Albelda SM; Singhal S. 2011. Neoadjuvant in situ gene-mediated cytotoxic immunotherapy improves postoperative outcomes in novel syngeneic esophageal carcinoma models. Cancer Gene Ther. Aug 26. [Epub ahead of print] [PubMed ID: 21869822]
Hepatoblastoma
Ellerkamp V; Armeanu-Ebinger S; Wenz J; Warmann SW; Schafer J; Ruck P; Fuchs J. 2011. Successful Establishment of an Orthotopic Hepatoblastoma In Vivo Model in NOD/LtSz-scid IL2Rγnull Mice. PLoS One. 6(8):e23419. [PubMed ID: 21853130]
Lieber J; Eicher C; Wenz J; Kirchner B; Warmann SW; Fuchs J; Armeanu-Ebinger S. 2011. The BH3 mimetic ABT-737 increases treatment efficiency of paclitaxel against hepatoblastoma. BMC Cancer. Aug 19;11(1):362. [PubMed ID: 21854558]
Hepatocellular carcinoma
Colombo F; Baldan F; Mazzucchelli S; Martin-Padura I; Marighetti P; Cattaneo A; Foglieni B; Spreafico M; Guerneri S; Baccarin M; Bertolini F; Rossi G; Mazzaferro V; Cadamuro M; Maggioni M; Agnelli L; Rebulla P; Prati D; Porretti L. 2011. Evidence of distinct tumour-propagating cell populations with different properties in primary human hepatocellular carcinoma. PLoS One.6(6):e21369. [PubMed ID: 21731718]
Immunotherapy
Canale S; Cocco C; Frasson C; Seganfreddo E; Di Carlo E; Ognio E; Sorrentino C; Ribatti D; Zorzoli A; Basso G; Dufour C; Airoldi I. 2011. Interleukin-27 inhibits pediatric B-acute lymphoblastic leukemia cell spreading in a preclinical model. Leukemia. Jun 24. [Epub ahead of print] [PubMed: 21701492]
Ferretti E; Montagna D; Di Carlo E; Cocco C; Ribatti D; Ognio E; Sorrentino C; Lisini D; Bertaina A; Locatelli F; Pistoia V; Airoldi I. 2011. Absence of IL-12Rβ2 in CD33(+)CD39(+) pediatric acute myeloid leukemia cells favours progression in NOD/SCID/IL2RγC-deficient mice. Leukemia. [Epub ahead of print] [PubMed ID: 21844875]
Markley JC, Sadelain M. 2010. “Interleukin (IL)-7 and IL-21 are superior to IL-2 and IL-15 in promoting human T cell-mediated rejection of systemic lymphoma in immunodeficient mice. Blood Apr 29;115(17):3508-19. [PubMed: 20190192]
Moon EK; Carpenito C; Sun J; Wang LC; Kapoor V; Predina JD; Powell DJ Jr; Riley J; June CH; Albelda SM. 2011. Expression of a Functional CCR2 Receptor Enhances Tumor Localization and Eradication by Human T Cells Expressing a Mesothelin-Specific Chimeric Antibody Receptor. Clin Cancer Res. Jul 15;17(14):4719-30. [PubMed: 21610146]
Reid GS; Shan X; Coughlin CM; Lassoued W; Pawel BR; Wexler LH; Thiele CJ; Tsokos M; Pinkus JL; Pinkus GS; Grupp SA; Vonderheide RH. 2009. Interferon-gamma-dependent infiltration of human T cells into neuroblastoma tumors in vivo. Clin Cancer Res 15(21):6602-8. [PubMed: 19825945]
Song DG; Ye Q; Carpenito C; Poussin M; Wang LP; Ji C; Figini M; June CH; Coukos G; Powell DJ Jr. 2011. In Vivo Persistence, Tumor Localization, and Antitumor Activity of CAR-Engineered T Cells Is Enhanced by Costimulatory Signaling through CD137 (4-1BB). Cancer Res. Jul 1;71(13):4617-27. [PubMed: 21546571]
Wege AK; Ernst W; Eckl J; Frankenberger B; Vollmann-Zwerenz A; Mannel DN; Ortmann O; Kroemer A; Brockhoff G. 2011. Humanized tumor mice - a new model to study and manipulate the immune response in advanced cancer therapy. Int J Cancer [Epub ahead of print] [PubMed: 21544806]
Zhao Y; Moon E; Carpenito C; Paulos C; Liu X; Brennan A; Chew A; Scholler J; Carroll RG; Levine BL; Albelda SM; June CH. Multiple injections of electroporated autologous T cells expressing a chimeric antigen receptor mediate regression of human disseminated tumor. Cancer Res Nov 15;70(22):9053-61. [PubMed: 20926399]
Leukemia cells from human patients / Leukemia stem cells
Agliano A; Martin-Padura I; Mancuso P; Marighetti P; Rabascio C; Pruneri G; Shultz LD; Bertolini F. 2008. Human acute leukemia cells injected in NOD/LtSz-scid/IL-2Rgamma null mice generate a faster and more efficient disease compared to other NOD/scid-related strains. Int J Cancer 123(9):2222-7. [PubMed: 18688847]
Bagnara D; Kaufman MS; Calissano C; Marsilio S; Patten P; Simone R; Chum P; Yan XJ; Allen SL; Kolitz JE; Baskar S; Rader C; Mellstedt H; Rabbani H; Lee A; Gregersen PK; Rai KR; Chiorazzi N. 2011. A novel adoptive transfer model of chronic lymphocytic leukemia suggests a key role for T lymphocytes in the disease. Blood 2011 Mar 8. [Epub ahead of print] [PubMed: 21385850]
Banerjee P; Tripp A; Lairmore MD; Crawford L; Sieburg M; Ramos JC; Harrington W Jr; Beilke MA; Feuer G. 2010. Adult T-cell leukemia/lymphoma development in HTLV-1-infected humanized SCID mice. Blood Apr 1;115(13):2640-8. [PubMed: 20124219]
Barrett DM; Zhao Y; Liu X; Jiang S; Carpenito C; Kalos M; Carroll RG; June CH; Grupp SA. 2011. Treatment of advanced leukemia in mice with mRNA engineered T cells. Hum Gene Ther. Aug 12. [Epub ahead of print] [PubMed ID: 21838572]
Benito J; Shi Y; Szymanska B; Carol H; Boehm I; Lu H; Konoplev S; Fang W; Zweidler-McKay PA; Campana D; Borthakur G; Bueso-Ramos C; Shpall E; Thomas DA; Jordan CT; Kantarjian H; Wilson WR; Lock R; Andreeff M; Konopleva M. 2011. Pronounced Hypoxia in Models of Murine and Human Leukemia: High Efficacy of Hypoxia-Activated Prodrug PR-104. PLoS One.6(8):e23108. [PubMed ID: 21853076]
Bonapace L; Bornhauser BC; Schmitz M; Cario G; Ziegler U; Niggli FK; Schäfer BW; Schrappe M; Stanulla M; Bourquin JP. 2010. Induction of autophagy-dependent necroptosis is required for childhood acute lymphoblastic leukemia cells to overcome glucocorticoid resistance. J Clin Invest Apr 1;120(4):1310-23. [PubMed: 20200450]
Chao MP; Alizadeh AA; Tang C; Myklebust JH; Varghese B; Gill S; Jan M; Cha AC; Chan CK; Tan BT; Park CY; Zhao F; Kohrt HE; Malumbres R; Briones J; Gascoyne RD; Lossos IS; Levy R; Weissman IL; Majeti R. 2010. Anti-CD47 Antibody Synergizes with Rituximab to Promote Phagocytosis and Eradicate Non-Hodgkin Lymphoma. Cell Sep 3;142(5):699-713. [PubMed: 20813259]
Chao MP; Tang C; Pachynski RK; Chin R; Majeti R; Weissman IL. 2011. Extra-nodal dissemination of non-Hodgkin's lymphoma requires CD47 and is inhibited by anti-CD47 antibody therapy. Blood. Aug 9. [Epub ahead of print] [PubMed ID: 21828138]
Chiu PP; Jiang H; Dick JE. 2010. Leukemia-initiating cells in human T-lymphoblastic leukemia exhibit glucocorticoid resistance. Blood Dec 9;116(24):5268-79. [PubMed: 20810926]
Chou FS; Wunderlich M; Griesinger A; Mulloy JC. 2011. N-RasG12D induces features of stepwise transformation in preleukemic human umbilical cord blood cultures expressing the AML1-ETO fusion gene. Blood Feb 17;117(7):2237-2240. [PubMed: 21200020]
Clappier E; Gerby B; Sigaux F; Delord M; Touzri F; Hernandez L; Ballerini P; Baruchel A; Pflumio F; Soulier J. 2011. Clonal selection in xenografted human T cell acute lymphoblastic leukemia recapitulates gain of malignancy at relapse. J Exp Med Apr 11;208(4):653-61. [PubMed: 21464223]
Daigle SR; Olhava EJ; Therkelsen CA; Majer CR; Sneeringer CJ; Song J; Johnston LD; Scott MP; Smith JJ; Xiao Y; Jin L; Kuntz KW; Chesworth R; Moyer MP; Bernt KM; Tseng JC; Kung AL; Armstrong SA; Copeland RA; Richon VM; Pollock RM. 2011. Selective Killing of Mixed Lineage Leukemia Cells by a Potent Small-Molecule DOT1L Inhibitor. Cancer Cell. Jul 12;20(1):53-65. [PubMed ID: 21741596]
Diamanti P; Cox CV; Blair A. 2011. Comparison of childhood leukemia initiating cell populations in NOD/SCID and NSG mice. Leukemia. Aug 23 [Epub ahead of print] [PubMed ID: 21860430]
Distler E; Wolfel C; Kohler S; Nonn M; Kaus N; Schnurer E; Meyer RG; Wehler TC; Huber C; Wolfel T; Hartwig UF; Herr W. 2008. Acute myeloid leukemia (AML)-reactive cytotoxic T lymphocyte clones rapidly expanded from CD8(+) CD62L((high)+) T cells of healthy donors prevent AML engraftment in NOD/SCID IL2Rgamma(null) mice. Exp Hematol 36(4):451-63. [PubMed: 18261837]
Goardon N; Marchi E; Atzberger A; Quek L; Schuh A; Soneji S; Woll P; Mead A; Alford KA; Rout R; Chaudhury S; Gilkes A; Knapper S; Beldjord K; Begum S; Rose S; Geddes N; Griffiths M; Standen G; Sternberg A; Cavenagh J; Hunter H; Bowen D; Killick S; Robinson L; Price A; Macintyre E; Virgo P; Burnett A; Craddock C; Enver T; Jacobsen SE; Porcher C; Vyas P. 2011. Coexistence of LMPP-like and GMP-like Leukemia Stem Cells in Acute Myeloid Leukemia. Cancer Cell Jan 18;19(1):138-52. [PubMed: 21251617]
Guo W; Schubbert S; Chen JY; Valamehr B; Mosessian S; Shi H; Dang NH; Garcia C; Theodoro MF; Varella-Garcia M; Wu H. 2011. Suppression of leukemia development caused by PTEN loss. Proc Natl Acad Sci U S A Jan 25;108(4):1409-14. [PubMed: 21212363]
Heaney NB; Pellicano F; Zhang B; Crawford L; Chu S; Kazmi SM; Allan EK; Jorgensen HG; Irvine AE; Bhatia R; Holyoake TL. 2010. Bortezomib induces apoptosis in primitive chronic myeloid leukemia cells including LTC-IC and NOD/SCID repopulating cells. Blood Mar 18;115(11):2241-50. [PubMed: 20068223]
Hu S; Niu H; Inaba H; Orwick S; Rose C; Panetta JC; Yang S; Pounds S; Fan Y; Calabrese C; Rehg JE; Campana D; Rubnitz JE; Baker SD. 2011. Activity of the Multikinase Inhibitor Sorafenib in Combination With Cytarabine in Acute Myeloid Leukemia. J Natl Cancer Inst 2011 Apr 12. [Epub ahead of print] [PubMed: 21487100]
Inuzuka H; Shaik S; Onoyama I; Gao D; Tseng A; Maser RS; Zhai B; Wan L; Gutierrez A; Lau AW; Xiao Y; Christie AL; Aster J; Settleman J; Gygi SP; Kung AL; Look T; Nakayama KI; DePinho RA; Wei W. 2011. SCFFBW7 regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction. Nature 2011 Mar 3;471(7336):104-9. [PubMed: 21368833]
Jaiswal S; Jamieson CH; Pang WW; Park CY; Chao MP; Majeti R; Traver D; van Rooijen N; Weissman IL. 2009. CD47 is upregulated on circulating hematopoietic stem cells and leukemia cells to avoid phagocytosis. Cell Jul 23;138(2):271-85. [PubMed: 19632178]
Janes MR; Limon JJ; So L; Chen J; Lim RJ; Chavez MA; Vu C; Lilly MB; Mallya S; Ong ST; Konopleva M; Martin MB; Ren P; Liu Y; Rommel C; Fruman DA. 2010. Effective and selective targeting of leukemia cells using a TORC1/2 kinase inhibitor. Nat Med Feb;16(2):205-13. [PubMed: 20072130]
Kikushige Y; Ishikawa F; Miyamoto T; Shima T; Urata S; Yoshimoto G; Mori Y; Iino T; Yamauchi T; Eto T; Niiro H; Iwasaki H; Takenaka K; Akashi K. 2011. Self-renewing hematopoietic stem cell is the primary target in pathogenesis of human chronic lymphocytic leukemia. Cancer Cell. Aug 16;20(2):246-59. [PubMed ID: 21840488]
Kong Y; Yoshida S; Saito Y; Doi T; Nagatoshi Y; Fukata M; Saito N; Yang SM; Iwamoto C; Okamura J; Liu KY; Huang XJ; Lu DP; Shultz LD; Harada M; Ishikawa F. 2008. CD34+CD38+CD19+ as well as CD34+CD38-CD19+ cells are leukemia-initiating cells with self-renewal capacity in human B-precursor ALL. Leukemia 22(6):1207-13. [PubMed: 18418410]
Kusy S; Gerby B; Goardon N; Gault N; Ferri F; Gérard D; Armstrong F; Ballerini P; Cayuela JM; Baruchel A; Pflumio F; Roméo PH. 2010. NKX3.1 is a direct TAL1 target gene that mediates proliferation of TAL1-expressing human T cell acute lymphoblastic leukemia. J Exp Med Sep 27;207(10):2141-56. [PubMed: 20855495]
le Viseur C; Hotfilder M; Bomken S; Wilson K; Rottgers S; Schrauder A; Rosemann A; Irving J; Stam RW; Shultz LD; Harbott J; Jurgens H; Schrappe M; Pieters R; Vormoor J. 2008. In childhood acute lymphoblastic leukemia, blasts at different stages of immunophenotypic maturation have stem cell properties. Cancer Cell 14(1):47-58. [PubMed: 18598943]
Majeti R; Chao MP; Alizadeh AA; Pang WW; Jaiswal S; Gibbs KD Jr; van Rooijen N; Weissman IL. 2009. CD47 is an adverse prognostic factor and therapeutic antibody target on human acute myeloid leukemia stem cells. Cell Jul 23;138(2):286-99. [PubMed: 19632179]
Martin MG; Welch JS; Uy GL; Fehniger TA; Kulkarni S; Duncavage EJ; Walter MJ. 2010. Limited engraftment of low-risk myelodysplastic syndrome cells in NOD/SCID gamma-C chain knockout mice. Leukemia Sep;24(9):1662-4. [PubMed: 20668474]
Medyouf H; Gao X; Armstrong F; Gusscott S; Liu Q; Gedman AL; Matherly LH; Schultz KR; Pflumio F; You MJ; Weng AP. 2010. Acute T-cell leukemias remain dependent on Notch signaling despite PTEN and INK4A/ARF loss. Blood Feb 11;115(6):1175-84. [PubMed: 20008304]
Montes R; Ayllón; Gutierrez-Aranda I; Prat I; Hern‡ndez-Lamas MC; Ponce L; Bresolin S; Te Kronnie G; Greaves M; Bueno C; Menendez P. 2011. Enforced expression of MLL-AF4 fusion in cord blood CD34+ cells enhances the hematopoietic repopulating cell function and clonogenic potential but is not sufficient to initiate leukemia. Blood May 5;117(18):4746-58. [PubMed: 21389315]
Morisot S; Wayne AS; Bohana-Kashtan O; Kaplan IM; Gocke CD; Hildreth R; Stetler-Stevenson M; Walker RL; Davis S; Meltzer PS; Wheelan SJ; Brown P; Jones RJ; Shultz LD; Civin CI. 2010. High frequencies of leukemia stem cells in poor-outcome childhood precursor-B acute lymphoblastic leukemias. Leukemia Nov;24(11):1859-66. [PubMed: 20739953]
Park E; Gang EJ; Hsieh YT; Schaefer P; Chae S; Klemm L; Huantes S; Loh M; Conway EM; Kang ES; Koo HH; Hofmann WK; Heisterkamp N; Pelus L; Keerthivasan G; Crispino J; Kahn M; Müschen M; Kim YM. 2011. Targeting survivin overcomes drug resistance in acute lymphoblastic leukemia. Blood. Aug 25;118(8):2191-9. [PubMed ID: 21715311]
Saito Y; Uchida N; Tanaka S; Suzuki N; Tomizawa-Murasawa M; Sone A; Najima Y; Takagi S; Aoki Y; Wake A; Taniguchi S; Shultz LD; Ishikawa F. 2010. Induction of cell cycle entry eliminates human leukemia stem cells in a mouse model of AML. Nat Biotechnol Mar;28(3):275-80. [PubMed: 20160717]
Sanchez PV; Perry RL; Sarry JE; Perl AE; Murphy K; Swider CR; Bagg A; Choi JK; Biegel JA; Danet-Desnoyers G; Carroll M. 2009. A robust xenotransplantation model for acute myeloid leukemia. Leukemia Nov;23(11):2109-17.[PubMed: 19626050]
Sarry JE; Murphy K; Perry R; Sanchez PV; Secreto A; Keefer C; Swider CR; Strzelecki AC; Cavelier C; Récher C; Mansat-De Mas V; Delabesse E; Danet-Desnoyers G; Carroll M. 2011. Human acute myelogenous leukemia stem cells are rare and heterogeneous when assayed in NOD/SCID/IL2Rγc-deficient mice. J Clin Invest Jan 4;121(1):384-95 [PubMed: 21157036]
Schmitz M; Breithaupt P; Scheidegger N; Cario G; Bonapace L; Meissner B; Mirkowska P; Tchinda J; Niggli FK; Stanulla M; Schrappe M; Schrauder A; Bornhauser BC; Bourquin JP. 2011. Xenografts of highly resistant leukemia recapitulate the clonal composition of the leukemogenic compartment. Blood. Aug 18;118(7):1854-64. [PubMed ID: 21670474]
Seif AE; Barrett DM; Milone M; Brown VI; Grupp SA; Reid GS. 2009. Long-term protection from syngeneic acute lymphoblastic leukemia by CpG ODN-mediated stimulation of innate and adaptive immune responses. Blood Sep 17;114(12):2459-66. [PubMed: 19636062]
Siegers GM; Felizardo TC; Mathieson AM; Kosaka Y; Wang XH; Medin JA; Keating A. 2011. Anti-leukemia activity of in vitro-expanded human gamma delta T cells in a xenogeneic ph leukemia model. PLoS One Feb 3;6(2):e16700. [PubMed: 21304898]
Sloma I; Jiang X; Eaves AC; Eaves CJ. 2010. Insights into the stem cells of chronic myeloid leukemia. Leukemia Review Nov;24(11):1823-33 [PubMed: 20861912]
Taussig DC; Miraki-Moud F; Anjos-Afonso F; Pearce DJ; Allen K; Ridler C; Lillington D; Oakervee H; Cavenagh J; Agrawal SG; Lister TA; Gribben JG; Bonnet D. 2008. Anti-CD38 antibody-mediated clearance of human repopulating cells masks the heterogeneity of leukemia-initiating cells. Blood. Aug 1;112(3):568-75. [PubMed ID: 18523148]
Wunderlich M; Chou FS; Link KA; Mizukawa B; Perry RL; Carroll M; Mulloy JC. 2010. AML xenograft efficiency is significantly improved in NOD/SCID-IL2RG mice constitutively expressing human SCF; GM-CSF and IL-3. Leukemia Oct;24(10):1785-8. [PubMed: 20686503]
Zhang B; Strauss AC, Chu S; Li M; Ho Y; Shiang K.-D; Snyder D.S; Huettner, C.S, Shultz L; Holyoake T; Bhatia, R. 2010. Effective Targeting of Quiescent Chronic Myelogenous Leukemia Stem Cells by Histone Deacetylase Inhibitors in Combination with Imatinib Mesylate. Cancer Cell May 18;17(5):427-42. [PubMed: 20478526]
Lung cancer
Serrano-Tejero D; Bleau AM; Fernandez-Garcia I; Fernandez-Marcelo T; Iniesta P; Ortiz-de-Solorzano C; Calvo A. 2011. Inhibition of telomerase activity preferentially targets aldehyde dehydrogenase-positive cancer stem-like cells in lung cancer. Mol Cancer. Aug 9;10(1):96. [PubMed ID: 21827695]
Lymphoma
Boss IW; Nadeau PE; Abbott JR; Yang Y; Mergia A; Renne R. 2011. A KSHV encoded ortholog of miR-155 induces human splenic B-cell expansion in NOD/LtSz-scid IL2R{gamma}null mice. J Virol. Oct;85(19):9877-86. [PubMed: 21813606]
Melanoma from human biopsies
Boiko AD; Razorenova OV; van de Rijn M; Swetter SM; Johnson DL; Ly DP; Butler PD; Yang GP; Joshua B; Kaplan MJ; Longaker MT; Weissman IL. 2010. Human melanoma-initiating cells express neural crest nerve growth factor receptor CD271. Nature Jul 1;466(7302):133-7. [PubMed: 19052619]
Boonyaratanakornkit JB; Yue L; Strachan LR; Scalapino KJ; Leboit PE; Lu Y; Leong SP; Smith JE; Ghadially R. 2010. Selection of Tumorigenic Melanoma Cells Using ALDH. J Invest Dermatol Dec;130(12):2799-808. [PubMed: 20739950]
Quintana E; Shackleton M; Foster HR; Fullen DR; Sabel MS; Johnson TM; Morrison SJ. 2010. Phenotypic Heterogeneity among Tumorigenic Melanoma Cells from Patients that Is Reversible and Not Hierarchically Organized. Cancer Cell Nov 16;18(5):510-23. [PubMed: 21075313]
Quintana E; Shackleton M; Sabel MS; Fullen DR; Johnson TM; Morrison SJ. 2008. Efficient tumour formation by single human melanoma cells. Nature 456(7222):593-8. [PubMed: 19052619]
Shackleton M; Quintana E. 2010. Progress in understanding melanoma propagation. Mol Oncol Review Oct;4(5):451-7 [PubMed: 20655286]
Melanoma metastasis
Carreno BM; Garbow JR; Kolar GR; Jackson EN; Engelbach JA; Becker-Hapak M; Carayannopoulos LN; Piwnica-Worms D; Linette GP. 2009. Immunodeficient mouse strains display marked variability in growth of human melanoma lung metastases. Clin Cancer Res May 15;15(10):3277-86. [PubMed: 19447870]
Kupas V; Weishaupt C; Siepmann D; Kaserer ML; Eickelmann M; Metze D; Luger TA; Beissert S; Loser K. 2011. RANK Is Expressed in Metastatic Melanoma and Highly Upregulated on Melanoma-Initiating Cells. J Invest Dermatol Apr;131(4):944-55. [PubMed: 21270824]
Ma J; Lin JY; Alloo A; Wilson BJ; Schatton T; Zhan Q; Murphy GF; Waaga-Gasser AM; Gasser M; Hodi FS; Frank NY; Frank MH. 2010. Isolation of tumorigenic circulating melanoma cells. Biochem Biophys Res Commun Nov 26;402(4):711-7. [PubMed: 20977885]
Metastasis
Lecomte N; Njardarson JT; Nagorny P; Yang G; Downey R; Ouerfelli O; Moore MA; Danishefsky SJ. 2011. Organic Synthesis Toward Small-Molecule Probes and Drugs Special Feature: Emergence of potent inhibitors of metastasis in lung cancer via syntheses based on migrastatin. Proc Natl Acad Sci U S A. Aug 1. [Epub ahead of print] [PubMed ID: 21808037]
Ovarian Cancer
Stewart JM, Shaw PA, Gedye C, Bernardini MQ, Neel BG, Ailles LE. 2011. Phenotypic heterogeneity and instability of human ovarian tumor-initiating cells. Proc Natl Acad Sci U S A Apr 19;108(16):6468-73. [PubMed: 21451132]
Primary Myelofibrosis
Wang X; Zhang W; Tripodi J; Lu M; Xu M; Najfeld V; Li Y; Hoffman R. 2010. Sequential treatment of CD34+ cells from patients with primary myelofibrosis with chromatin modifying agents eliminate JAK2V617F positive NOD/SCID marrow repopulating cells. Blood Dec 23;116(26):5972-82. [PubMed: 20858855]
Preservation of tumor microenvironment after lung cancer biopsy engraftment
Simpson-Abelson MR; Sonnenberg GF; Takita H; Yokota SJ; Conway TF Jr; Kelleher RJ Jr; Shultz LD; Barcos M; Bankert RB. 2008. Long-term engraftment and expansion of tumor-derived memory T cells following the implantation of non-disrupted pieces of human lung tumor into NOD-scid IL2Rgamma(null) mice. J Immunol 180(10):7009-18. [PubMed: 18453623]
Prostate cancer stem cells
Goldstein AS; Huang J; Guo C; Garraway IP; Witte ON. 2010. Identification of a cell of origin for human prostate cancer. Science Jul 30;329(5991):568-71. [PubMed: 20671189]
Solid cancer cell line xenografts
Liu X, Lai L, Wang X, Xue L, Leora S, Wu J, Hu S, Zhang K, Kuo ML, Zhou L, Zhang H, Wang Y, Wang Y, Zhou B, Nelson RA, Zheng S, Zhang S, Chu PG, Yen Y. 2011. Ribonucleotide reductase small subunit M2B prognoses better survival in colorectal cancer. Cancer Res May 1;71(9):3202-13. [PubMed: 21415168]
Diabetes
Pearson T; Shultz LD; Lief J; Burzenski L; Gott B; Chase T; Foreman O; Rossini AA; Bottino R; Trucco M; Greiner DL. 2008. A new immunodeficient hyperglycaemic mouse model based on the Ins2 ( Akita ) mutation for analyses of human islet and beta stem and progenitor cell function. Diabetologia 51(8):1449-56. [PubMed: 18563383]
King M, Pearson T, Shultz LD, Leif J, Bottino R, Trucco M, Atkinson MA, Wasserfall C, Herold KC, Woodland RT, Schmidt MR, Woda BA, Thompson MJ, Rossini AA, Greiner DL. 2008. A new Hu-PBL model for the study of human islet alloreactivity based on NOD-scid mice bearing a targeted mutation in the IL-2 receptor gamma chain gene. Clin Immunol 2008 Mar;126(3):303-14. [PubMed: 18096436]
King M, Pearson T, Rossini AA, Shultz LD, Greiner DL. 2008. Humanized mice for the study of type 1 diabetes and beta cell function. Ann N Y Acad Sci 2008 Dec;1150:46-53. Review. [PubMed: 19120266]
Shultz LD, Pearson T, King M, Giassi L, Carney L, Gott B, Lyons B, Rossini AA, Greiner DL. 2007. Humanized NOD/LtSz-scid IL2 receptor common gamma chain knockout mice in diabetes research. Ann N Y Acad Sci 2007 Apr;1103:77-89. Review. [PubMed: 17332083]
Whitfield-Larry F, Young EF, Talmage G, Fudge E, Azam A, Patel S, Largay J, Byrd W, Buse J, Calikoglu AS, Shultz LD, Frelinger JA. 2011. HLA-A2-Matched Peripheral Blood Mononuclear Cells From Type 1 Diabetic Patients, but not Nondiabetic Donors, Transfer Insulitis to NOD-scid/{gamma}cnull/HLA-A2 Transgenic Mice Concurrent With the Expansion of Islet-Specific CD8+ T cells. Diabetes 2011 Apr 26. [Epub ahead of print] [PubMed: 21521873]
Stem cells / regenerative medicine
Differentiation of embryonic stem cells into hematopoetic cells
Gori JL; Tian X; Swanson D; Gunther R; Shultz LD; McIvor RS; Kaufman DS. 2010. In vivo selection of human embryonic stem cell-derived cells expressing methotrexate-resistant dihydrofolate reductase. Gene Ther Feb;17(2):238-49. [PubMed: 19829316]
Ledran MH; Krassowska A; Armstrong L; Dimmick I; Renström J; Lang R; Yung S; Santibanez-Coref M; Dzierzak E; Stojkovic M; Oostendorp RA; Forrester L; Lako M. 2008. Efficient hematopoietic differentiation of human embryonic stem cells on stromal cells derived from hematopoietic niches. Cell Stem Cell Jul 3;3(1):85-98 [PubMed: 18593561]
Differentiation of embryonic stem cells into endothelial cells
Gori JL; Tian X; Swanson D; Gunther R; Shultz LD; McIvor RS; Kaufman DS. 2010. In vivo selection of human embryonic stem cell-derived cells expressing methotrexate-resistant dihydrofolate reductase. Gene Ther Feb;17(2):238-49. [PubMed:19829316]
Ma M; Ding S; Lundqvist A; San H; Fang F; Konoplyannikov M; Berry C; Beltran LE; Chen G; Kovacic JC; Boehm M. 2010. Major histocompatibility complex-I expression on embryonic stem cell-derived vascular progenitor cells is critical for syngeneic transplant survival. Stem Cells Sep;28(9):1465-75. [PubMed: 20629173]
Papapetrou EP; Lee G; Malani N; Setty M; Riviere I; Tirunagari LM; Kadota K; Roth SL; Giardina P; Viale A; Leslie C; Bushman FD; Studer L; Sadelain M. 2011. Genomic safe harbors permit high β-globin transgene expression in thalassemia induced pluripotent stem cells. Nat Biotechnol Jan;29(1):73-8. [PubMed: 21151124]
Ruiz S; Brennand K; Panopoulos AD; Herrerías A; Gage FH; Izpisua-Belmonte JC. 2010. High-Efficient Generation of Induced Pluripotent Stem Cells from Human Astrocytes. PLoS ONE 5(12): e15526. [PubMed: 21170306]
Sullivan GJ; Hay DC; Park IH; Fletcher J; Hannoun Z; Payne CM; Dalgetty D; Black JR; Ross JA; Samuel K; Wang G; Daley GQ; Lee JH; Church GM; Forbes SJ; Iredale JP; Wilmut I. 2010. Generation of functional human hepatic endoderm from human induced pluripotent stem cells. Hepatology. Jan;51(1):329-35. [PubMed: 19877180]
Szabo E; Rampalli S; Risueño RM; Schnerch A; Mitchell R; Fiebig-Comyn A; Levadoux-Martin M; Bhatia M. Direct conversion of human fibroblasts to multilineage blood progenitors. Nature Nov 25;468(7323):521-6. [PubMed: 21057492]
Tian X; Hexum MK; Penchev VR; Taylor RJ; Shultz LD; Kaufman DS. 2009. Bioluminescent imaging demonstrates that transplanted human embryonic stem cell-derived CD34(+) cells preferentially develop into endothelial cells. Stem Cells Nov;27(11):2675-85. [PubMed: 19711457]
Human mammary stem cells
Eirew P; Stingl J; Raouf A; Turashvili G; Aparicio S; Emerman JT; Eaves CJ. 2008. A method for quantifying normal human mammary epithelial stem cells with in vivo regenerative ability. Nat Med 14(12):1384-1389. [PubMed: 19029987]
Other
Benabdallah BF; Allard E; Yao S; Friedman G; Gregory PD; Eliopoulos N; Fradette J; Spees JL; Haddad E; Holmes MC; Beauséjour CM. 2010. Targeted gene addition to human mesenchymal stromal cells as a cell-based plasma-soluble protein delivery platform. Cytotherapy May;12(3):394-9. [PubMed: 20331411]
Toxicity
Cai S, Wang H, Bailey B, Ernstberger A, Juliar BE, Sinn AL, Chan RJ, Jones DR, Mayo LD, Baluyut AR, Goebel WS, Pollok KE. 2011. Humanized Bone Marrow Mouse Model as a Preclinical Tool to Assess Therapy-Mediated Hematotoxicity. Clin Cancer Res Apr 15;17(8):2195-2206. [PubMed: 21487065]
