NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(Stock Number 005557)
Humanized NSG mice and Patient-derived Xenograft resource now available
The most versatile immunodeficient strain
The NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ mice, commonly known as NOD scid gamma (NSG), are severely immunocompromised, featuring absence of mature T or B cells, lack of functional NK cells and deficiency in cytokine signaling. The strain combines the features of the NOD/ShiLtJ (Stock Number 001976) background, the severe combined immune deficiency mutation (scid, which is caused by a spontaneous mutation in the Prkdc gene), and IL2 receptor gamma chain deficiency. As a result, engraftment of human hematopoietic stem cells and peripheral-blood mononuclear cells in the NSG mice is greater than that in any other mouse strain.
Discussion forum
This forum encourages researchers to communicate with colleagues by sharing their experiences using the NSG mouse in disease research. Please register today and join in the discussion.
Applications
Haematopoiesis and humanized mice
- Infectious disease
- Autoimmune disorders
- Blood borne cancers
- Solid tumors
- Cancer stem cells
Immunology models comparison
Comparison of the NSG mouse with other published immunodeficient strains.
Husbandry tips
Information on breeding performance of the NSG mouse compiled by our experienced animal caretakers.
Housing conditions
Description of the general housing conditions for the NSG mouse at The Jackson Laboratory.
References
An ongoing, growing list of published research using the NSG mouse.
Printable fact sheet
A single-page PDF providing key information on the NSG mouse.
