NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ (stock #005557)
The most versatile immunodeficient strain
The 005557 strain mice are severely immunocompromised, featuring absence of mature T or B cells, lack of functional NK cells and deficiency in cytokine signaling. The strain combines the features of the NOD/ShiLtJ (stock #001976) background, the severe combined immune deficiency mutation (scid, which is caused by a spontaneous mutation in the Prkdc gene), and IL2 receptor gamma chain deficiency. As a result, engraftment of human hematopoietic stem cells and peripheral-blood mononuclear cells in the 005557 strain mice is greater than that in any other mouse strain.
Applications
- Haematopoiesis and humanized mice
- Infectious disease
- Autoimmune disorders
- Blood borne cancers
- Solid tumors
- Cancer stem cells
Immunology models comparison
Comparison of the 005557 strain with other published immunodeficient strains.
Husbandry tips
Information on breeding performance of the 005557 strain compiled by our experienced animal caretakers.
Housing conditions
Description of the general housing conditions for the 005557 strain at The Jackson Laboratory.
References
An ongoing, growing list of published research using the 005557 strain.
Printable fact sheet
A single-page PDF providing key information on the 005557 strain.
