NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(Stock Number 005557)

The most versatile immunodeficient strain

The NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ mice, commonly known as NOD scid gamma (NSG), are severely immunocompromised, featuring absence of mature T or B cells, lack of functional NK cells and deficiency in cytokine signaling. The strain combines the features of the NOD/ShiLtJ (Stock Number 001976) background, the severe combined immune deficiency mutation (scid, which is caused by a spontaneous mutation in the Prkdc gene), and IL2 receptor gamma chain deficiency. As a result, engraftment of human hematopoietic stem cells and peripheral-blood mononuclear cells in the NSG mice is greater than that in any other mouse strain.


Discussion forum

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Applications

  • The 005557 strain mouseHaematopoiesis and humanized mice
  • Infectious disease
  • Autoimmune disorders
  • Blood borne cancers
  • Solid tumors
  • Cancer stem cells

Immunology models comparison

Comparison of the NSG mouse with other published immunodeficient strains.

Husbandry tips

Information on breeding performance of the NSG mouse compiled by our experienced animal caretakers.

Housing conditions

Description of the general housing conditions for the NSG mouse at The Jackson Laboratory.

References

An ongoing, growing list of published research using the NSG mouse.

Printable fact sheet

A single-page PDF providing key information on the NSG mouse.

JAX® Mice database

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