Comparison of Alzheimer's disease mouse models

Phenotypes displayed by genetic models

Mouse Model (Stock Number)
     Plaques Tangles Synaptic loss Neuronal loss Cognitive Deficit
B6SJL-Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/J (006554)
  In hippocampus and cortex at two months No By four months Yes Spatial learning deficit at four to five months
B6C3-Tg(tetO-APPSwInd)885Dbo/J (006004)
  In forebrain at two to six months No Not reported Not reported Hyperactivity
B6.Cg-Tg(PDGFB-APPSwInd)20Lms/2J (006293)
  In hippocampus and cortex at six to eight months No At two to four months Not reported Spatial learning deficit at six to seven months
B6C3-Tg(APPswe,PSEN1dE9)85Dbo/J (004462)
B6.Cg-Tg(APPswe,PSEN1dE9)85Dbo/J (005864)
  In hippocampus and cortex at six to seven months No Dystrophic neurites by nine months Not reported Spatial learning deficit at seven months
C57BL/6-Tg(Thy1-APPSwDutIowa)BWevn/J (007027)
  In hippocampus and cortex by three months No Not reported Not reported Learning and memory deficit by three months
B6;C3-Tg(Prnp-ITM2B/APP695*42)A12Emcg/J (007002)
  In cerebellum at three months; later in forebrain No Not reported Not reported Not reported
B6.129-Tg(APPSw)40Btla/J (005300)
  In hippocampus and cortex at 14 months No Dystrophic neurites by 14 months Not reported Not reported
STOCK Mapttm1(EGFP)Klt Tg(MAPT)8cPdav/J (004808)
B6.Cg-Mapttm1(EGFP)Klt Tg(MAPT)8cPdav/J (005491)
  No Tau aggregates at two months in neocortex and hippocampus Yes Yes Not reported
B6;C3-Tg(Prnp-MAPT*P301S)PS19Vle/J (008169)
  No In neocortex and hippocampus by five months Yes In hippocampus by eight to nine months Not reported
C57BL/6-Tg(tetO-CDK5R1/GFP)337Lht/J (005706)
  No Neurofibrillary tangle-like pathology Yes In cortex and hippocampus Impaired LTP, spatial learning and memory

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