Fragile X

Fragile X syndrome is a hereditary condition which causes a wide range of mental impairment, from mild learning disabilities to severe mental retardation. It is the most common cause of genetically-inherited mental impairment. Fragile X is also associated with several physical and behavioral characteristics. Researches have recently made significant breakthroughs in understanding the complex causes and inheritance patterns of Fragile X (The Fragile X Foundation, http://www.fragilex.org).

JAX® Mice Models

FVB.129P2-Fmr1tm1Cgr/J

Stock Number 004624

Homozygous mutants are viable and fertile. They were backcrossed for 11 generations onto the FVB background. They are homozygous for the 129P2/OlaHsd wild–type Pde6b allele and do not suffer from blindness due to retinal degeneration. They have more long dendritic spines, fewer short dendritic spines and more spines with an immature morphology than wild–type littermates.

Reference

The Dutch-Belgian Fragile X Consortium. (Bakker CE, Verheij C, Willemsen R, van der Helm R, Oerlemans F, Vermey M, Bygrave A, Hoogeveen AT, Oostra BA, Reyniers E, et al.). 1994. Fmr1 knockout mice: a model to study fragile X mental retardation. Cell 78:23-33.

JAX® Mice for Fragile X research

See a complete list of JAX® Mice for fragile X research