Parkinson's Disease Mouse Model Resource
The Parkinson's Disease Mouse Model Resource (PDMMR) is funded by an anonymous foundation to provide genetically engineered mice and information useful for their selection and use. The resource also serves as an archive of genetically stable mouse models.
The Repository distributes Parkinson’s disease models that are useful for the study of the basic pathophysiology of PD, and for testing new therapies. Also available are "research tool" strains including transgenics that express marker genes in affected brain regions, and strains with systems for regulating gene expression (e.g. Cre recombinase and tet-inducible promoters) in specific types of neurons.
- JAX® Mice useful to study Parkinson’s disease
- Parkinson’s disease mouse model list (.pdf)
- Neurobiology tools mouse model list (.pdf)
- Neurobiology resource manual (request form)
- Novel Familial Parkinson's Disease Model (JAX NOTES #491 Fall 2003)
- Novel Strain With No ADP-ribosyltransferase I Enzymatic Activity (JAX NOTES #491 Fall 2003)
Dr. Michael Sasner, who has a PhD in neuroscience from the University of Connecticut and has been at The Jackson Laboratory since 1998, serves as a resource for scientists seeking information about existing models and will oversee the selection, importation, and distribution of new models. Dr. Sasner also coordinates the Alzheimer's Disease Mouse Model Resource. If you have questions or suggestions for potential new strains for the Parkinson's Disease Mouse Model Repository, please contact Dr. Sasner at mike.sasner@jax.org.
