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- Description
- Phenotype
- Genes & alleles
- Genotyping
- Health & husbandry
- References
- Purchasing information
- Terms of Use
Description
The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.
Strain Information
Former Names B6.C3 A/a md (Changed: 15-DEC-04 ) Type Congenic; Mutant Strain; Spontaneous Mutation; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Species laboratory mouse Background Strain C57BL/6J Donor Strain C3H/HeJ Generation N9+N1
Related Strains
Strains carrying Mgrn1md allele
000309 B6.C3-Mgrn1md/J 000223 C3H/HeJ-Mgrn1md/J 001277 STOCK Mgrn1md Igl-1b Igl1-rlo/J View Strains carrying Mgrn1md (3 strains)
000809 C3H/HeJ-Mgrn1md-2J/J
Phenotype
Phenotype Information
assigned by genotype
The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.
Mgrn1md/Mgrn1md
C3H/HeJ-Mgrn1md/JThis mouse can be used to support research in many areas including:Mgrn1md related
Dermatology Research
Color and White Spotting Defects
Skin and Hair Texture Defects
Genes & Alleles
Gene & Allele Information
| Allele Symbol | Mgrn1md | ||
|---|---|---|---|
| Allele Name | mahoganoid | ||
| Allele Type | Spontaneous | ||
| Common Name(s) | md; | ||
| Strain of Origin | C3H/HeJ | ||
| Gene Symbol and Name | Mgrn1, mahogunin, ring finger 1 | ||
| Chromosome | 16 | ||
| Gene Common Name(s) | 2610042J20Rik; KIAA0544; N28182; RGD1311862; RIKEN cDNA 2610042J20 gene; RNF156; expressed sequence N28182; mKIAA0544; mahoganoid; md; nc; non-agouti curly; non-agouti-curly; | ||
| General Note | The original md mutation arose in the C3H/HeJ strain. This gene is similar to mahogany (Atrnmg) in its effects on coat color, but causes less darkening of the back, ears, and tail of agouti mice (J:13379)(J:13791). | ||
| Molecular Note | The mutation in md has been attributed to a 5 kb retroviral insertion located in the intronic region 5' of exon 12. Northern analysis and RT-PCR indicate that the expression of transcript is greatly reduced in these mice. [MGI Ref ID J:80182] | ||
| Allele Symbol | a | ||
| Allele Name | nonagouti | ||
| Allele Type | Spontaneous | ||
Genotyping
Genotyping Information
This strain will not have a genotyping protocol or one is not currently available.
Helpful Links
Genotyping resources and troubleshooting
References
References
Additional References
Mgrn1md relatedBagher P; Jiao J; Owen Smith C; Cota CD; Gunn TM. 2006. Characterization of Mahogunin Ring Finger-1 expression in mice. Pigment Cell Res 19(6):635-43. [PubMed: 17083490] [MGI Ref ID J:119125]
Concepcion D; Flores-Garcia L; Hamilton BA. 2009. Multipotent genetic suppression of retrotransposon-induced mutations by Nxf1 through fine-tuning of alternative splicing. PLoS Genet 5(5):e1000484. [PubMed: 19436707] [MGI Ref ID J:149430]
He L; Lu XY; Jolly AF; Eldridge AG; Watson SJ; Jackson PK; Barsh GS; Gunn TM. 2003. Spongiform degeneration in mahoganoid mutant mice. Science 299(5607):710-2. [PubMed: 12560552] [MGI Ref ID J:81466]
Lane PW. 1960. mahoganoid, md Mouse News Lett 22:35. [MGI Ref ID J:13379]
Miller KA; Gunn TM; Carrasquillo MM; Lamoreux ML; Galbraith DB ; Barsh GS. 1997. Genetic studies of the mouse mutations mahogany and mahoganoid. Genetics 146(4):1407-15. [PubMed: 9258683] [MGI Ref ID J:41964]
Phan LK; Chung WK; Leibel RL. 2006. The mahoganoid mutation (Mgrn1md) improves insulin sensitivity in mice with mutations in the melanocortin signaling pathway independently of effects on adiposity. Am J Physiol Endocrinol Metab 291(3):E611-20. [PubMed: 16638826] [MGI Ref ID J:112364]
Phan LK; Lin F; LeDuc CA; Chung WK; Leibel RL. 2002. The mouse mahoganoid coat color mutation disrupts a novel C3HC4 RING domain protein. J Clin Invest 110(10):1449-59. [PubMed: 12438443] [MGI Ref ID J:80182]
Phillips RJ; Fisher G. 1979. Non-agouti curly: change of symbol. Mouse News Lett 60:46-47. [MGI Ref ID J:13791]
Health & husbandry
Health & Colony Maintenance Information
Currently there no information available for this strain. This may be due to the supply level of this strain.
Purchasing information
Pricing, Supply Level & Notes, Controls, General Terms & Conditions
Pricing
| Pricing for USA, Canada and Mexico shipping destinations |
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Animals Provided
Price (US dollars $) Cryorecovery Fee $1900.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Additional Supply Details
| Pricing for International shipping destinations |
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Animals Provided
Price (US dollars $) Cryorecovery Fee $2470.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Additional Supply Details
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Supply Details
| Standard Supply | Cryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information. |
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| Supply Notes |
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Payment Terms and Conditions
Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.
See Terms of Use tab for General Terms and Conditions
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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