Go to JAX® Mice Query Form

Strain Name:

ABP/LeJ

Stock Number:

000004

Availability:

Repository-Cryopreserved


General Terms and Conditions

Former Name      ABP/J    (Changed: 15-DEC-04 )
Genes & Alleles   Adamts20;   Adamts20bt;   Bmp5;   Bmp5se;   Oca2;   Oca2p;   Tgfa;   Tgfawa1;   Tyrp1;   Tyrp1b;


Product Information

Strain Details

Type Inbred Strain
Additional information on Inbred Strains.
Type JAX® GEMM® Strain - Spontaneous Mutation
Additional information on JAX® GEMM® Strains.
Specieslaboratory mouse
GenerationF136p

Appearance
pink-eyed beige with belt, wavy fur, and short ears
Related Genotype: a/a Tyrp1b/Tyrp1b Adamts20bt/Adamts20bt Oca2p/Oca2p Bmp5se/Bmp5se Tgfawa1/Tgfawa1

Important Note
This strain is homozygous for Adamts20bt, Bmp5se and Tgfawa1.

Strain Description
Mice homozygous for the Tgfawa1 spontaneous mutation are recognizable at 2 or 3 days of age by their curly whiskers. The first coat is strongly waved and straight in later coats. Most of the whiskers also become straight, but the guard hairs are curved and shorter than normal. Some homozygotes have eyelids open at birth.

Mice homozygous for the recessive Adamts20bt mutation have a dorsal and a ventral unpigmented patch posterior to the midline of the trunk with the dorsal patch usually being larger than the ventral patch. These patches run in a more transverse orientation across the mouse than lengthwise and often extend around the sides of the mouse to form a white belt. The size of the patches can vary from approximately 1 to 20 percent of the surface. Unlike other spotting mutations, no variability in phenotype was identified when belted was transferred onto the C57BL/6J or JU/CtLm backgrounds (Lamoreaux 1999). Murray and Snell reported finding a small belly spot on a few heterozygotes so the Adamts20bt mutation may not be entirely recessive.

Strain Development
In 1954 Drs. William Murray and George Snell reported the belted mutation (Adamts20bt) that arose spontaneously in strain DBA at The University of Maine. They combined the mutations pink-eyed dilution (p) and waved 1 (Tgfawa1) with belted into a linkage testing stock called BP. Waved 1 had been found in a mixed stock by Crew in 1933. Later in the 1960s brown (Tyrp1b) and short ear (Bmpsse) from the SEC/1 strain were added by Dr. Allan Griffin and the stock was called ABP. ABP was probably sibling mated although no records are available. It was used specifically for testing in irradiation experiments. In 1969 it was taken by P. Lane and inbred as a multiple recessive inbred strain ABP/Le. It was cryopreserved at F64 in 1978 by mating homozygotes.

Gene & Allele Details

Allele Symbol Adamts20bt
Allele Name belted
Strain of OriginDBA
Gene Symbol and Name Adamts20, a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 20
Chromosome 15
Gene Common Name(s) ADAMTS-20; GON-1; belted; bt;
Molecular Note The mutation was identified as C to T transition at position 1598 that generates a substitution of leucine for proline in the ADAM cysteine-rich domain. [MGI Ref ID J:84755]
 
Allele Symbol Bmp5se
Allele Name short ear
Common Name(s) seGnJ;
Strain of Originmice from Abbie Lathrop mouse farm
Gene Symbol and Name Bmp5, bone morphogenetic protein 5
Chromosome 9
Gene Common Name(s) AU023399; MGC34244; expressed sequence AU023399; se; short ear;
Molecular Note The C to T transition creates a stop codon at amino acid 208. The resulting truncated protein does not include the carboxy terminal signaling portion of the molecule. [MGI Ref ID J:21484]
 
Allele Symbol Oca2p
Allele Name pink-eyed dilution
Common Name(s) p;
Strain of OriginAsiatic fancy mice
Gene Symbol and Name Oca2, oculocutaneous albinism II
Chromosome 7
Gene Common Name(s) BEY; BEY1; BEY2; BOCA; D15S12; D7H15S12; D7Icr28RN; D7Nic1; DNA segment, Chr 7, Institute for Cancer Research 28RN; DNA segment, Chr 7, Nicholls 1; DNA segment, Chr 7, human D15S12; EYCL; EYCL2; EYCL3; HCL3; P; PED; SHEP1; p; pink-eyed dilution;
General Note

p is a very old mutation carried in many varieties of fancy mice (J:12958). It has been suggested that the original mutation occurred in Japanese wild mice, Mus musculus molossinus (J:19782).

Homozygotes have pink eyes with pigmentation very much reduced but not completely absent in both the retina and choroid. The black pigment of the hair is very much diluted, but the yellow pigment is only slightly affected. Pigment granules are irregular and shred-like in shape. The small amount of pigment they contain is of wild-type color (J:12970, J:12958). The fine structure of the pigment granules was said by Moyer (J:5001) to be disrupted, but Hearing et al. \R(J:5346) found the structure to be normal, with premature termination of the melanizationprocess.

In tissue culture of the eye, the amount of pigment formed can be increased by increasing the concentration of tyrosine. This suggests that p may block the melanin-synthesizing pathway by interference with tyrosine supply (J:12726). The site of gene action is in the melanocytes and not in either the dermis or the epidermis (J:7988).

A presumed p gene has been cloned (J:2206). It was isolated from mouse melanoma and melanocyte libraries and is missing or altered in six independent p mutant alleles (J:2206). By sequence comparison, the human P locus, deletions of which are associated with hypopigmentation, is orthologous to p (J:2206). P maps to Chr 15q, near the Prader--Willi syndrome locus. On the basis of this location, the p mutation has been proposed to provide a mouse model for Prader--Willi syndrome, for Angelman syndrome, for one form of hypomelanosis of Ito (J:3253), and for type II oculocutaneous albinism (J:3600). A small nuclear ribonucleoprotein particle gene Snrpn maps near p and its human ortholog in the homologous Prader--Willi region of human Chromosome 15 (J:3623). Snrpn appears to be a better candidate for the Prader-Willi syndrome ortholog. P is deleted in human type II oculocutaneous albinism, making p a model for this disease (J:3600).

 
Allele Symbol Tgfawa1
Allele Name waved 1
Common Name(s) wa-1; waved;
Gene Symbol and Name Tgfa, transforming growth factor alpha
Chromosome 6
Gene Common Name(s) RATTGFAA; TFGA; TGFAA; wa-1; wa1; waved 1;
General Note Tgfawa1, waved 1, recessive. The waved 1 mutation was found in a mixed mouse colony (J:13034). Homozygotes are recognizable at 2 or 3 days of age by their curly whiskers. The first coat is strongly waved, but the hair becomes straight in latercoats. Most of the whiskers also become straight, but the guard hairs are curved and shorter than normal. All hair types of the first coat show loose curves, possibly because of a defective internal root sheath which may prevent the hair shaft from moving upward at a normal rate (J:15247). Bennett and Gresham (J:13115) found that many Tgfawa1/Tgfawa1 mice had eyelids open at birth and ascribed the condition to a closely linked gene, eo, but the possibility that open eyelids is a pleiotropic effect of Tgfawa1 was not excluded. Corneal damage in mice born with open eyelids was attributed to birth trauma.
Molecular Note Although the specific molecular lesion in wa1 mice has not been identified, Northern blot analysis revealed that expression of TGFalpha transcript was reduced in homozygous mice, and crosses between wa1 mice and Tgfatm1Unc mice confirmed that these mutations are allelic. [MGI Ref ID J:4605]
 
Allele Symbol Tyrp1b
Allele Name brown
Strain of OriginC57BL
Gene Symbol and Name Tyrp1, tyrosinase-related protein 1
Chromosome 4
Gene Common Name(s) B; CAS2; CATB; GP75; TRP; TRP-1; TRP1; TYRP; Tyrp; b; b-PROTEIN; brown; iris stromal atrophy; isa; tyrosinase-related protein;
General Note Tyrp1b, brown, recessive. This type mutant of the brown locus is an old mutation of the mouse fancy. The eumelanin of the hair and eyes is brown rather than black. The pigment granules also appear brown rather than black and are spheroid rather than ovoid in shape (J:12970). The fine structure of the developing pigment granules is fibrillar, like that of wild type mice, but the appearance of the mature granule may be more coarsely granular (J:5346, J:5001, J:5068). The granules incorporate twice as much 14C-tyrosine as normal (J:12173).
Molecular Note A G-to-A transition point mutation at position 329 was shown by revertant analysis to be responsible for the mutant phenotype seen in the brown mutant. This mutation is predicted to change a cysteine residue to a tyrosine in the encoded protein. Three other point mutations in the brown sequence were identified, but do not contribute to the mutant phenotype. [MGI Ref ID J:44435]

Control Information

  Control
   None Available
 
  Considerations for Choosing Controls

Related Strains

Strains carrying   Bmp5se allele
000578   B6 x STOCK Tyrc-ch Bmp5se +/+ Myo6sv/J
000056   B6.Cg-Bmp5se/J
000285   B6.Cg-Rorasg + +/+ Myo5ad Bmp5se/J
000253   DLS/LeJ
000644   SEA/GnJ
000270   SEC/1GnLeJ
View Strains carrying   Bmp5se     (6 strains)

Strains carrying   Oca2p allele
000577   B6 x STOCK a Oca2p Hps5ru2 Ednrbs/J
001059   B6By.Cg-Oca2p/J
000619   FS/EiJ
000306   STOCK Dll3pu + Tyrc-ch/+ Oca2p Tyrc-ch/J
001618   STOCK Oca2p/Oca2p Prop1df/J
View Strains carrying   Oca2p     (5 strains)

Strains carrying   Tgfawa1 allele
002863   B6.Cg-Tgfawa1/J
View Strains carrying   Tgfawa1     (1 strain)

Strains carrying   Tyrp1b allele
000571   B6.Cg-Whrnwi Tyrp1b/+ +/J
000027   B6.D-Tyrp1b m/J
000670   DBA/1J
000265   MY/HuLeJ
001045   SI/Col Tyrp1b Dnahc11iv/J
000064   STOCK a Tyrp1b Sisi/J
002238   STOCK a Tyrp1b shmy/J
001432   STOCK a/a Tyrp1b sks/Tyrp1b +/J
000594   STOCK T(2;8)26H a/T(2;8)26H a Tyrp1+/Tyrp1b/J
001101   STOCK T(3;4)5Rk Tyrp1b/J
000274   TSJ/LeJ
View Strains carrying   Tyrp1b     (11 strains)

Strains carrying other alleles of Adamts20
000570   C57BL/6J-Slc45a2uw Adamts20bt-2J/J
View Strains carrying other alleles of Adamts20     (1 strain)

Strains carrying other alleles of Bmp5
001496   C57BL/6J-Bmp5se-4J/J
005420   C;129S7 Gt(ROSA)26Sor-Bmp5cfe-se7J/J
005421   CBy;B6-Bmp5cfe-se8J/J
View Strains carrying other alleles of Bmp5     (3 strains)

View Strains carrying other alleles of Oca2     (18 strains)

Strains carrying other alleles of Tgfa
002219   B6.129P2-Tgfatm1Ard/J
View Strains carrying other alleles of Tgfa     (1 strain)

Strains carrying other alleles of Tyrp1
000068   C57BL/6J-Tyrp1b-J/J
000093   C57BL/6J-Tyrp1b-cJ/J
000671   DBA/2J
003588   LT/SvEi
006252   LT/SvEiJ
002142   STOCK 11R30m/J
000594   STOCK T(2;8)26H a/T(2;8)26H a Tyrp1+/Tyrp1b/J
View Strains carrying other alleles of Tyrp1     (7 strains)

Additional Web Information

JAX® NOTES, Fall 1994; 459. The Waved-1 (wa1) Mutation, Chromosome 6.

Research Applications

This mouse can be used to support research in many areas including:

Adamts20bt related

Cell Biology Research
Protein Processing

Dermatology Research
Color and White Spotting Defects

Bmp5se related

Developmental Biology Research
Growth Defects
Skeletal Defects

Oca2p related

Dermatology Research
Color and White Spotting Defects

Mouse/Human Gene Homologs
albinism, oculocutaneous type II, OCA2

Neurobiology Research
Angelman syndrome

Tgfawa1 related

Cancer Research
Growth Factors/Receptors/Cytokines

Dermatology Research
Skin and Hair Texture Defects

Endocrine Deficiency Research
Skin Defects

Immunology and Inflammation Research
Growth Factors/Receptors/Cytokines

Neurobiology Research
Behavioral and Learning Defects

Tyrp1b related

Dermatology Research
Color and White Spotting Defects

Mouse/Human Gene Homologs
oculocutaneous albinism type III

References

Additional References

Price and Supply Information

Strain Name: ABP/LeJ
Stock Number: 000004

Price Details

IMPORTANT NOTE: Prices are based on shipping destination. To view prices, select your shipping destination.

*NO Shipping Destination selected!

 

Supply Details

Standard SupplyRepository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information.
Supply Notes Cryorecovery - Standard.
The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two males and two females (two pairs) will be provided, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the delivery time to approximately 25 weeks. At least one member of each pair will be of known genotype and will carry the mutation if it is a mutant strain. Please note that pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Price represents a repository maintenance fee, which includes the cost of recovery of the strain from the cryopreservation resource and the periodic replacement of the frozen embryos used for recovery.

Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
One to two pairs will be recovered to establish a Dedicated Supply of mice. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services: Tel: 1-800-422-6423 or 1-207-288-5845; Email: jaxservices@jax.org.
Genomic DNA is available for this strain from the Mouse DNA Resource.

LicensingSee General Terms and Conditions below  
Control InformationView Control Information in Strain Details.

General Terms and Conditions

View JAX® Mice & Services Conditions of Use.

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
Ordering and Purchasing Information

      Purchasing Information
      JAX® Mice Orders
      Surgical Services

Contact Information
Orders & Technical Support
Tel: 800.422.6423 or 207.288.5845
Fax: 207.288.6150
Technical Support Email Form

Go to JAX® Mice Query Form

(2.15)