JAX Mice Database - 000004 ABP/LeJ

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Strain Name:	ABP/LeJ
Stock Number:	000004
Availability:	Repository-Cryopreserved

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General Terms and Conditions

Former Name	ABP/J (Changed: 15-DEC-04 )
Genes & Alleles	Adamts20; Adamts20^bt; Bmp5; Bmp5^se; Oca2; Oca2^p; Tgfa; Tgfa^wa1; Tyrp1; Tyrp1^b;

Product Information

Strain Details

Type Inbred Strain

Additional information on Inbred Strains.

Type JAX^® GEMM^® Strain - Spontaneous Mutation

Additional information on JAX^® GEMM^® Strains.

Species laboratory mouse

Generation F136p

Appearance
pink-eyed beige with belt, wavy fur, and short ears
Related Genotype: a/a Tyrp1^b/Tyrp1^b Adamts20^bt/Adamts20^bt Oca2^p/Oca2^p Bmp5^se/Bmp5^se Tgfa^wa1/Tgfa^wa1
Important Note
This strain is homozygous for Adamts20^bt, Bmp5^se and Tgfa^wa1.
Strain Description
Mice homozygous for the Tgfa^wa1 spontaneous mutation are recognizable at 2 or 3 days of age by their curly whiskers. The first coat is strongly waved and straight in later coats. Most of the whiskers also become straight, but the guard hairs are curved and shorter than normal. Some homozygotes have eyelids open at birth.
Mice homozygous for the recessive Adamts20^bt mutation have a dorsal and a ventral unpigmented patch posterior to the midline of the trunk with the dorsal patch usually being larger than the ventral patch. These patches run in a more transverse orientation across the mouse than lengthwise and often extend around the sides of the mouse to form a white belt. The size of the patches can vary from approximately 1 to 20 percent of the surface. Unlike other spotting mutations, no variability in phenotype was identified when belted was transferred onto the C57BL/6J or JU/CtLm backgrounds (Lamoreaux 1999). Murray and Snell reported finding a small belly spot on a few heterozygotes so the Adamts20^bt mutation may not be entirely recessive.
Strain Development
In 1954 Drs. William Murray and George Snell reported the belted mutation (Adamts20^bt) that arose spontaneously in strain DBA at The University of Maine. They combined the mutations pink-eyed dilution (p) and waved 1 (Tgfa^wa1) with belted into a linkage testing stock called BP. Waved 1 had been found in a mixed stock by Crew in 1933. Later in the 1960s brown (Tyrp1^b) and short ear (Bmps^se) from the SEC/1 strain were added by Dr. Allan Griffin and the stock was called ABP. ABP was probably sibling mated although no records are available. It was used specifically for testing in irradiation experiments. In 1969 it was taken by P. Lane and inbred as a multiple recessive inbred strain ABP/Le. It was cryopreserved at F64 in 1978 by mating homozygotes.

Gene & Allele Details

Allele Symbol		Adamts20^bt
Allele Name		belted
Strain of Origin		DBA
Gene Symbol and Name		Adamts20, a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 20
Chromosome		15
Gene Common Name(s)		ADAMTS-20; GON-1; belted; bt;
Molecular Note		The mutation was identified as C to T transition at position 1598 that generates a substitution of leucine for proline in the ADAM cysteine-rich domain. [MGI Ref ID J:84755]

Allele Symbol		Bmp5^se
Allele Name		short ear
Common Name(s)		se^GnJ;
Strain of Origin		mice from Abbie Lathrop mouse farm
Gene Symbol and Name		Bmp5, bone morphogenetic protein 5
Chromosome		9
Gene Common Name(s)		AU023399; MGC34244; expressed sequence AU023399; se; short ear;
Molecular Note		The C to T transition creates a stop codon at amino acid 208. The resulting truncated protein does not include the carboxy terminal signaling portion of the molecule. [MGI Ref ID J:21484]

Allele Symbol		Oca2^p
Allele Name		pink-eyed dilution
Common Name(s)		p;
Strain of Origin		Asiatic fancy mice
Gene Symbol and Name		Oca2, oculocutaneous albinism II
Chromosome		7
Gene Common Name(s)		BEY; BEY1; BEY2; BOCA; D15S12; D7H15S12; D7Icr28RN; D7Nic1; DNA segment, Chr 7, Institute for Cancer Research 28RN; DNA segment, Chr 7, Nicholls 1; DNA segment, Chr 7, human D15S12; EYCL; EYCL2; EYCL3; HCL3; P; PED; SHEP1; p; pink-eyed dilution;
General Note		p is a very old mutation carried in many varieties of fancy mice (J:12958). It has been suggested that the original mutation occurred in Japanese wild mice, Mus musculus molossinus (J:19782). Homozygotes have pink eyes with pigmentation very much reduced but not completely absent in both the retina and choroid. The black pigment of the hair is very much diluted, but the yellow pigment is only slightly affected. Pigment granules are irregular and shred-like in shape. The small amount of pigment they contain is of wild-type color (J:12970, J:12958). The fine structure of the pigment granules was said by Moyer (J:5001) to be disrupted, but Hearing et al. \R(J:5346) found the structure to be normal, with premature termination of the melanizationprocess. In tissue culture of the eye, the amount of pigment formed can be increased by increasing the concentration of tyrosine. This suggests that p may block the melanin-synthesizing pathway by interference with tyrosine supply (J:12726). The site of gene action is in the melanocytes and not in either the dermis or the epidermis (J:7988). A presumed p gene has been cloned (J:2206). It was isolated from mouse melanoma and melanocyte libraries and is missing or altered in six independent p mutant alleles (J:2206). By sequence comparison, the human P locus, deletions of which are associated with hypopigmentation, is orthologous to p (J:2206). P maps to Chr 15q, near the Prader--Willi syndrome locus. On the basis of this location, the p mutation has been proposed to provide a mouse model for Prader--Willi syndrome, for Angelman syndrome, for one form of hypomelanosis of Ito (J:3253), and for type II oculocutaneous albinism (J:3600). A small nuclear ribonucleoprotein particle gene Snrpn maps near p and its human ortholog in the homologous Prader--Willi region of human Chromosome 15 (J:3623). Snrpn appears to be a better candidate for the Prader-Willi syndrome ortholog. P is deleted in human type II oculocutaneous albinism, making p a model for this disease (J:3600).

Allele Symbol		Tgfa^wa1
Allele Name		waved 1
Common Name(s)		wa-1; waved;
Gene Symbol and Name		Tgfa, transforming growth factor alpha
Chromosome		6
Gene Common Name(s)		RATTGFAA; TFGA; TGFAA; wa-1; wa1; waved 1;
General Note		Tgfa^wa1, waved 1, recessive. The waved 1 mutation was found in a mixed mouse colony (J:13034). Homozygotes are recognizable at 2 or 3 days of age by their curly whiskers. The first coat is strongly waved, but the hair becomes straight in latercoats. Most of the whiskers also become straight, but the guard hairs are curved and shorter than normal. All hair types of the first coat show loose curves, possibly because of a defective internal root sheath which may prevent the hair shaft from moving upward at a normal rate (J:15247). Bennett and Gresham (J:13115) found that many Tgfa^wa1/Tgfa^wa1 mice had eyelids open at birth and ascribed the condition to a closely linked gene, eo, but the possibility that open eyelids is a pleiotropic effect of Tgfa^wa1 was not excluded. Corneal damage in mice born with open eyelids was attributed to birth trauma.
Molecular Note		Although the specific molecular lesion in wa1 mice has not been identified, Northern blot analysis revealed that expression of TGFalpha transcript was reduced in homozygous mice, and crosses between wa1 mice and Tgfa^tm1Unc mice confirmed that these mutations are allelic. [MGI Ref ID J:4605]

Allele Symbol		Tyrp1^b
Allele Name		brown
Strain of Origin		C57BL
Gene Symbol and Name		Tyrp1, tyrosinase-related protein 1
Chromosome		4
Gene Common Name(s)		B; CAS2; CATB; GP75; TRP; TRP-1; TRP1; TYRP; Tyrp; b; b-PROTEIN; brown; iris stromal atrophy; isa; tyrosinase-related protein;
General Note		Tyrp1^b, brown, recessive. This type mutant of the brown locus is an old mutation of the mouse fancy. The eumelanin of the hair and eyes is brown rather than black. The pigment granules also appear brown rather than black and are spheroid rather than ovoid in shape (J:12970). The fine structure of the developing pigment granules is fibrillar, like that of wild type mice, but the appearance of the mature granule may be more coarsely granular (J:5346, J:5001, J:5068). The granules incorporate twice as much ¹⁴C-tyrosine as normal (J:12173).
Molecular Note		A G-to-A transition point mutation at position 329 was shown by revertant analysis to be responsible for the mutant phenotype seen in the brown mutant. This mutation is predicted to change a cysteine residue to a tyrosine in the encoded protein. Three other point mutations in the brown sequence were identified, but do not contribute to the mutant phenotype. [MGI Ref ID J:44435]

Control Information

	Control
	None Available

Considerations for Choosing Controls

Related Strains

Strains carrying Bmp5^se allele

000578 B6 x STOCK Tyr^c-ch Bmp5^se +/+ Myo6^sv/J

000056 B6.Cg-Bmp5^se/J

000285 B6.Cg-Rora^sg + +/+ Myo5a^d Bmp5^se/J

000253 DLS/LeJ

000644 SEA/GnJ

000270 SEC/1GnLeJ

View Strains carrying Bmp5^se (6 strains)

Strains carrying Oca2^p allele

000577 B6 x STOCK a Oca2^p Hps5^ru2 Ednrb^s/J

001059 B6By.Cg-Oca2^p/J

000619 FS/EiJ

000306 STOCK Dll3^pu + Tyr^c-ch/+ Oca2^p Tyr^c-ch/J

001618 STOCK Oca2^p/Oca2^p Prop1^df/J

View Strains carrying Oca2^p (5 strains)

Strains carrying Tgfa^wa1 allele

002863 B6.Cg-Tgfa^wa1/J

View Strains carrying Tgfa^wa1 (1 strain)

Strains carrying Tyrp1^b allele

000571 B6.Cg-Whrn^wi Tyrp1^b/+ +/J

000027 B6.D-Tyrp1^b m/J

000670 DBA/1J

000265 MY/HuLeJ

001045 SI/Col Tyrp1^b Dnahc11^iv/J

000064 STOCK a Tyrp1^b Si^si/J

002238 STOCK a Tyrp1^b shmy/J

001432 STOCK a/a Tyrp1^b sks/Tyrp1^b +/J

000594 STOCK T(2;8)26H a/T(2;8)26H a Tyrp1⁺/Tyrp1^b/J

001101 STOCK T(3;4)5Rk Tyrp1^b/J

000274 TSJ/LeJ

View Strains carrying Tyrp1^b (11 strains)

Strains carrying other alleles of Adamts20

000570 C57BL/6J-Slc45a2^uw Adamts20^bt-2J/J

View Strains carrying other alleles of Adamts20 (1 strain)

Strains carrying other alleles of Bmp5

001496 C57BL/6J-Bmp5^se-4J/J

005420 C;129S7 Gt(ROSA)26Sor-Bmp5^cfe-se7J/J

005421 CBy;B6-Bmp5^cfe-se8J/J

View Strains carrying other alleles of Bmp5 (3 strains)

Strains carrying other alleles of Oca2

000090 129S1/Sv-Oca2⁺ Tyr⁺ Kitl^Sl-J/J

000091 129T1/Sv-Oca2⁺ Tyr^c-ch Dnd1^Ter/J

001279 129T1/Sv-Oca2⁺ Tyr^c-ch-Aft/J

000822 B6 x 129S1/SvEi Oca2⁺ Tyr⁺-Vsx2^or-J/J

002460 C3H/HeJ-Oca2^p-J Is(7;1)40H/J

000513 C3H/HeJ-Oca2^p-J/J

001136 C57BL/6J-Oca2^p-un+2J/J

001506 C57BL/6J-Oca2^p-un+3J/J

001810 C57BL/6J-Oca2^p-un+4J/J

001513 C57BL/6J-Oca2^p-un+5J/J

001499 C57BL/6J-Oca2^p-un+6J/J

001033 C57BL/6J-Oca2^p-un+J/J

000028 C57BL/6J-Oca2^p-un/J

000494 J.Cg-Oca2⁺ Tyr⁺ Lyst^bg/J

001584 STOCK Oca2^p-J/Oca2^p-bs/J

001585 STOCK Oca2^p-d/Oca2^p-25H/J

000823 STOCK Oca2^p-d/Oca2^p-6H/J

001747 STOCK Oca2^p-d/Oca2^p-cp/J

View Strains carrying other alleles of Oca2 (18 strains)

Strains carrying other alleles of Tgfa

002219 B6.129P2-Tgfa^tm1Ard/J

View Strains carrying other alleles of Tgfa (1 strain)

Strains carrying other alleles of Tyrp1

000068 C57BL/6J-Tyrp1^b-J/J

000093 C57BL/6J-Tyrp1^b-cJ/J

000671 DBA/2J

003588 LT/SvEi

006252 LT/SvEiJ

002142 STOCK 11R30m/J

000594 STOCK T(2;8)26H a/T(2;8)26H a Tyrp1⁺/Tyrp1^b/J

View Strains carrying other alleles of Tyrp1 (7 strains)

Additional Web Information

JAX^® NOTES, Fall 1994; 459. The Waved-1 (wa1) Mutation, Chromosome 6.

Research Applications

This mouse can be used to support research in many areas including:

Adamts20^bt related

Cell Biology Research
Protein Processing

Dermatology Research
Color and White Spotting Defects

Bmp5^se related

Developmental Biology Research
Growth Defects
Skeletal Defects

Oca2^p related

Dermatology Research
Color and White Spotting Defects

Mouse/Human Gene Homologs
albinism, oculocutaneous type II, OCA2

Neurobiology Research
Angelman syndrome

Tgfa^wa1 related

Cancer Research
Growth Factors/Receptors/Cytokines

Dermatology Research
Skin and Hair Texture Defects

Endocrine Deficiency Research
Skin Defects

Immunology and Inflammation Research
Growth Factors/Receptors/Cytokines

Neurobiology Research
Behavioral and Learning Defects

Tyrp1^b related

Dermatology Research
Color and White Spotting Defects

Mouse/Human Gene Homologs
oculocutaneous albinism type III

References

Additional References

Price and Supply Information

Strain Name:	ABP/LeJ
Stock Number:	000004

Price Details

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Supply Details

Standard Supply	Repository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information.
Supply Notes	Cryorecovery - Standard. The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two males and two females (two pairs) will be provided, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the delivery time to approximately 25 weeks. At least one member of each pair will be of known genotype and will carry the mutation if it is a mutant strain. Please note that pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Price represents a repository maintenance fee, which includes the cost of recovery of the strain from the cryopreservation resource and the periodic replacement of the frozen embryos used for recovery. *Cryorecovery to establish a Dedicated Supply for greater quantities of mice.* One to two pairs will be recovered to establish a Dedicated Supply of mice. Price by quotation. For more information on Dedicated Supply, please contact JAX^® Services: Tel: 1-800-422-6423 or 1-207-288-5845; Email: jaxservices@jax.org. Genomic DNA is available for this strain from the Mouse DNA Resource.
Licensing	See General Terms and Conditions below
Control Information	View Control Information in Strain Details.

General Terms and Conditions

View JAX^® Mice & Services Conditions of Use.

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

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Go to JAX^® Mice Query Form

000578	B6 x STOCK Tyr^c-ch Bmp5^se +/+ Myo6^sv/J
000056	B6.Cg-Bmp5^se/J
000285	B6.Cg-Rora^sg + +/+ Myo5a^d Bmp5^se/J
000253	DLS/LeJ
000644	SEA/GnJ
000270	SEC/1GnLeJ

000577	B6 x STOCK a Oca2^p Hps5^ru2 Ednrb^s/J
001059	B6By.Cg-Oca2^p/J
000619	FS/EiJ
000306	STOCK Dll3^pu + Tyr^c-ch/+ Oca2^p Tyr^c-ch/J
001618	STOCK Oca2^p/Oca2^p Prop1^df/J

000571	B6.Cg-Whrn^wi Tyrp1^b/+ +/J
000027	B6.D-Tyrp1^b m/J
000670	DBA/1J
000265	MY/HuLeJ
001045	SI/Col Tyrp1^b Dnahc11^iv/J
000064	STOCK a Tyrp1^b Si^si/J
002238	STOCK a Tyrp1^b shmy/J
001432	STOCK a/a Tyrp1^b sks/Tyrp1^b +/J
000594	STOCK T(2;8)26H a/T(2;8)26H a Tyrp1⁺/Tyrp1^b/J
001101	STOCK T(3;4)5Rk Tyrp1^b/J
000274	TSJ/LeJ

001496	C57BL/6J-Bmp5^se-4J/J
005420	C;129S7 Gt(ROSA)26Sor-Bmp5^cfe-se7J/J
005421	CBy;B6-Bmp5^cfe-se8J/J

000090	129S1/Sv-Oca2⁺ Tyr⁺ Kitl^Sl-J/J
000091	129T1/Sv-Oca2⁺ Tyr^c-ch Dnd1^Ter/J
001279	129T1/Sv-Oca2⁺ Tyr^c-ch-Aft/J
000822	B6 x 129S1/SvEi Oca2⁺ Tyr⁺-Vsx2^or-J/J
002460	C3H/HeJ-Oca2^p-J Is(7;1)40H/J
000513	C3H/HeJ-Oca2^p-J/J
001136	C57BL/6J-Oca2^p-un+2J/J
001506	C57BL/6J-Oca2^p-un+3J/J
001810	C57BL/6J-Oca2^p-un+4J/J
001513	C57BL/6J-Oca2^p-un+5J/J
001499	C57BL/6J-Oca2^p-un+6J/J
001033	C57BL/6J-Oca2^p-un+J/J
000028	C57BL/6J-Oca2^p-un/J
000494	J.Cg-Oca2⁺ Tyr⁺ Lyst^bg/J
001584	STOCK Oca2^p-J/Oca2^p-bs/J
001585	STOCK Oca2^p-d/Oca2^p-25H/J
000823	STOCK Oca2^p-d/Oca2^p-6H/J
001747	STOCK Oca2^p-d/Oca2^p-cp/J

000068	C57BL/6J-Tyrp1^b-J/J
000093	C57BL/6J-Tyrp1^b-cJ/J
000671	DBA/2J
003588	LT/SvEi
006252	LT/SvEiJ
002142	STOCK 11R30m/J
000594	STOCK T(2;8)26H a/T(2;8)26H a Tyrp1⁺/Tyrp1^b/J

Strain Name:

ABP/LeJ

Stock Number:

000004

Availability:

Repository-Cryopreserved

General Terms and Conditions

Product Information

Strain Details

Gene & Allele Details

Control Information

Related Strains

Additional Web Information

Research Applications

References

Price and Supply Information

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General Terms and Conditions

The Jackson Laboratory's Genotype Promise