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Strain Name:

STOCK Hk Tyrc/J

Stock Number:

000006

Availability:

Repository-Cryopreserved

Price and Supply Information

General Terms and Conditions

Genes & Alleles   Hk;   Tyr;   Tyrc;

Product Information

Strain Details

Type JAX® GEMM® Strain - Mutant Stock
Additional information on JAX® GEMM® Strains.
Type JAX® GEMM® Strain - Spontaneous Mutation
Specieslaboratory mouse
GenerationF60p

Appearance
white with hooked tail and displaced anus
Related Genotype: a/a Tyrc/Tyrc Hk/+ or a/a Tyrc/Tyrc Hk/Hk

Strain Description
While mice carrying the Hk mutation often have a hooked curl at the end of a shortened tail, this mutation may more consistently result in a displaced anus that is positioned posterior to the normal site and is more slit-shaped than circular. In some instances the anus has been located in the beginning of the tail and a depression was found to extend partway down the ventral side of the tail (Holman, 1951). The Hk mutation is semidominant with homozygotes often showing a shorter, more affected tail than heterozygotes (P.W. Lane Personal Communication).

Strain Development
The Hk mutation arose spontaneously. It was identified in 1949 in a piebald shaker stock and was sent from SP Holman to GD Snell in 1951. This was subsequently crossed once to a rex (Re) stock, crossed three times to C57BL/6, crossed once to AKR, crossed twice to A/Sn, and then crossed once to C57BL/6J before PW Lane inbred the line by sibling mating. This resulted in an inbred background homozygous for Tyrc and a and segregating for Hk. In 1978 embryos were generated for cryopreservation by breeding Hk/+ females with Hk/Hk males when the strain was at F59.

Mammalian Phenotype Terms assigned by genotype

The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.

Hk/Hk

        Background Not Specified
  • digestive/alimentary phenotype
  • abnormal anus morphology (MGI Ref ID J:14985)
  • limbs/digits/tail phenotype
  • abnormal caudal vertebrae morphology (MGI Ref ID J:14985)
  • kinked tail (MGI Ref ID J:14985)
  • short tail (MGI Ref ID J:14985)
  • skeleton phenotype
  • abnormal caudal vertebrae morphology (MGI Ref ID J:14985)

Hk/Hk+

        Background Not Specified
  • digestive/alimentary phenotype
  • abnormal anus morphology (MGI Ref ID J:14985)
    • the often slit-shaped anus is posterior to normal location, often on the tail, extending sometimes to half the length of the tail
    • mice with this feature may or may not have a short tail or a hook-tail
    • anus tends to be bare rather than surrounded by hair
  • limbs/digits/tail phenotype
  • abnormal caudal vertebrae morphology (MGI Ref ID J:14985)
  • kinked tail (MGI Ref ID J:14985)
    • end of tail is fishhook-like
    • length and degree of bending is variable
  • short tail (MGI Ref ID J:14985)
    • this feature is variable
  • skeleton phenotype
  • abnormal caudal vertebrae morphology (MGI Ref ID J:14985)

Gene & Allele Details

Allele Symbol Hk
Allele Name hook
Strain of Originpiebald shaker stock
 
Allele Symbol Tyrc
Allele Name albino
Common Name(s) c;
Strain of Originold mutant of the mouse fancy
Gene Symbol and Name Tyr, tyrosinase
Chromosome 7
Gene Common Name(s) C; OCA1A; OCAIA; SHEP3; albino; c; skc35; skin/coat color 35;
General Note Tyrc, albino. This very old mutant was already known in Greek and Roman times. Hair and eyes are completely devoid of pigment (J:5436, J:5001, J:30725). The albino mutation affects the amount of tyrosinase, and thus of melanin, in pigment cells, but does not interfere with the production of pigment cells themselves (J:12173, J:13092). Melanocytes with melanosomes showing normal fine structure occur in the retina and hair follicles. Pigment granules are smaller and fewer than normal and completely lack melanin (J:5346, J:5001, J:30725). Tyrosinase is almost absent (J:12173).Although Tyr is the structural gene for tyrosinase, some albino mutations may affect tyrosinase enzyme regulation rather than structure (J:6611), suggesting that these mutations affect tyrosinase inhibition (J:5346), presumably via control regions of the gene. All the mutant alleles are recessive to wild type in phenotype, but heterozygotes with wild type produce intermediate amounts of tyrosinase (J:12173).Albino-locus mutants with lightly pigmented eyes have a reduced number of fibers of the optic nerve going to the ipsilateral lateral geniculate nucleus of the brain. This is probably a secondary effect of reduced tyrosinase activity or amount of pigment in the pigmentepithelium, since genes at other loci that reduce eye pigmentation also cause the same anomaly (J:5436, J:6064).Abnormal retinal pathways disrupted at the optic chiasm that occur in albinism can be corrected with a Tyr normal transgene (J:22320).Lipofuscin is a terminal oxidation product pigment that accumulates with age. In a cross of C57BL/6J and BALB/cJ, which differ in cardiac deposition of the pigment, this trait segregated with albinism, and is controlled by the Tyr locus (J:15460).Tyrc homozygotes do not perform as well as normal in a number of behavioral tests. It is likely that this effect is mediated, at least in part, by defective vision resulting from lack of retinal pigment (J:5470, J:5360, J:5378).
Molecular Note The specific mutation in the albino allele is a G to C transversion causing an amino acid change from cysteine to serine. This mutation introduces a DdeI enzyme restriction site. [MGI Ref ID J:10889] [MGI Ref ID J:40223]

Control Information

  Control
   Heterozygote from the colony
 
  Considerations for Choosing Controls
  Control Pricing Information for JAX® GEMM® Strains

Related Strains

Strains carrying   Tyrc allele
001017   AKXD10/TyJ
000765   AKXD13/TyJ
000954   AKXD15/TyJ
000958   AKXD16/TyJ
001093   AKXD18/TyJ
001062   AKXD21/TyJ
000947   AKXD22/TyJ
000969   AKXD24/TyJ
000777   AKXD6/TyJ
000763   AKXD9/TyJ
000409   B10.129P-H1b Hbbd Tyrc Ea7a/(5M)oSnJ
000418   B10.129P-H1b Tyrc Hbbd/(5M)nSnJ
000432   B10.C-H1b Hbbd Tyrc/(41N)SnJ
000383   B6.C-Tyrc H1b Hbbd/ByJ
001759   STOCK A Tyrc Sha/J
View Strains carrying   Tyrc     (15 strains)

View Strains carrying other alleles of Tyr     (31 strains)

Research Applications

This mouse can be used to support research in many areas including:

Hk related

Developmental Biology Research
Skeletal Defects

Tyrc related

Dermatology Research
Color and White Spotting Defects (oculocutaneous albinism, type I)

Mouse/Human Gene Homologs
albinism, tyrosine negative

References

Additional References

Price and Supply Information

Strain Name: STOCK Hk Tyrc/J
Stock Number: 000006

Price Details

IMPORTANT NOTE: Prices are based on shipping destination. The shipping destinations are:

*Pricing for Shipping Destination selected:

        International

Price(s) in US dollars ($)
Cryorecovery Fee $2470.00

Supply Details

Standard SupplyRepository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information.
Supply Notes Cryorecovery - Standard.
The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two males and two females (two pairs) will be provided, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the delivery time to approximately 25 weeks. At least one member of each pair will be of known genotype and will carry the mutation if it is a mutant strain. Please note that pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Price represents a repository maintenance fee, which includes the cost of recovery of the strain from the cryopreservation resource and the periodic replacement of the frozen embryos used for recovery.

Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
One to two pairs will be recovered to establish a Dedicated Supply of mice. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services: Tel: 1-800-422-6423 or 1-207-288-5845; Email: jaxservices@jax.org.
Genomic DNA is available for this strain from the Mouse DNA Resource.

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The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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