Strain Name:

B6.CBACaGr-Tmem79ma/J

Stock Number:

000022

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Availability:

Cryopreserved - Ready for recovery

Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Former Names B6.CBAGr-ma/J    (Changed: 17-APR-14 )
Type Congenic; Mutant Strain;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Additional information on Congenic nomenclature.
Specieslaboratory mouse
Background Strain C57BL/6J
Donor Strain CBA/Gr
GenerationN23p
Generation Definitions

Development
The matted (ma) mutation arose spontaneously in the CBA/Gr inbred strain in the 1950's. It was imported into The Jackson Laboratory from University College of London in 1957. After 4 sibling matings it was crossed to C57BL/6J and backcrossed to N6 before sibling matings with forced heterozygosis were made. The strain was inbred to N6F40 in this manner. It was given to Dr. E. S. Russell at N6F24 in 1968, maintained via backcross-intercross to C57BL/6J, and cryopreserved in 1979 from the matings of C57BL/6J females with homozygous (ma/ma) males at generation N6F40N22F1.

Control Information

  Control
   Untyped from the colony
   000664 C57BL/6J
 
  Considerations for Choosing Controls

Related Strains

Strains carrying   Tmem79ma allele
000281   STOCK a/a Tmem79ma Flgft/J
View Strains carrying   Tmem79ma     (1 strain)

Strains carrying other alleles of Tmem79
014103   129;FVB-Tmem79m1J/GrsrJ
View Strains carrying other alleles of Tmem79     (1 strain)

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
Models with phenotypic similarity to human diseases where etiology is unknown or involving genes where ortholog is unknown.
Dermatitis, Atopic
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

Flgft/Flgft Tmem79ma/Tmem79ma

        involves: C57BL/6J * CBA/CaGr
  • integument phenotype
  • *normal* integument phenotype
    • mice were examined at 5 weeks of age when the effects of the flaky-skin mutation on skin condition are not yet seen   (MGI Ref ID J:30359)
    • abnormal coat/ hair morphology   (MGI Ref ID J:30359)
      • abnormal coat appearance
        • clumped hair and bald spots develop in mutant mice by 4 weeks of age   (MGI Ref ID J:30359)
        • the hair of older non-agouti black mice may appear brown although a pigment defect is not reported   (MGI Ref ID J:30359)
        • alopecia
          • bald patches occur in areas that are rubbed, breaking hair shafts   (MGI Ref ID J:30359)
        • matted coat
          • clumped hair can be seen in mutant mice by 4 weeks of age   (MGI Ref ID J:30359)
          • saliva introduced during grooming causes the hair to mat   (MGI Ref ID J:30359)
          • the matted appearance is easily seen when the fur is stroked opposite the normal direction of the coat   (MGI Ref ID J:30359)
      • abnormal hair shaft morphology
        • hair shaft above matrix does not develop normally in some mutant mice   (MGI Ref ID J:30359)
        • hairs tend to break and split   (MGI Ref ID J:30359)
    • abnormal hair follicle matrix region morphology
      • found where hair shafts become structurallly abnormal   (MGI Ref ID J:30359)

Tmem79ma/Tmem79ma

        B6.CBACaGr-Tmem79ma/J
  • integument phenotype
  • abnormal coat appearance   (MGI Ref ID J:202453)
    • alopecia
      • occasional at 32 weeks of age   (MGI Ref ID J:202453)
    • brittle hair
      • hair breakage at 32 weeks of age   (MGI Ref ID J:202453)
    • matted coat   (MGI Ref ID J:202453)
  • abnormal corneocyte envelope morphology
    • cornified cell envelopes are discontinuous, uneven, and highly disorganized   (MGI Ref ID J:202453)
  • abnormal hair cortex keratinization
    • keratinization defects   (MGI Ref ID J:202453)
  • abnormal hair follicle development
    • distorted hair follicle morphogenesis   (MGI Ref ID J:202453)
  • acanthosis
  • impaired skin barrier function
    • increased transepidermal water loss   (MGI Ref ID J:202453)
  • orthokeratosis
    • prominent, with dermal inflammatory infiltrates   (MGI Ref ID J:202453)
  • skin inflammation
    • marked skin inflammation with a broad spectrum of pathologies   (MGI Ref ID J:202453)
    • some mice exhibit profound lesions and excoriation   (MGI Ref ID J:202453)
    • skin inflammation following treatment with house dust might allergen is enhanced   (MGI Ref ID J:202453)
    • dermatitis
      • spontaneous, progressive dermatitis-like skin inflammation   (MGI Ref ID J:202453)
      • spontaneous atopic dermatitis   (MGI Ref ID J:202453)
  • immune system phenotype
  • blepharitis
    • occasional blepharitis and eyelid dermatitis in some mice   (MGI Ref ID J:202453)
  • increased IgE level   (MGI Ref ID J:202453)
  • skin inflammation
    • marked skin inflammation with a broad spectrum of pathologies   (MGI Ref ID J:202453)
    • some mice exhibit profound lesions and excoriation   (MGI Ref ID J:202453)
    • skin inflammation following treatment with house dust might allergen is enhanced   (MGI Ref ID J:202453)
    • dermatitis
      • spontaneous, progressive dermatitis-like skin inflammation   (MGI Ref ID J:202453)
      • spontaneous atopic dermatitis   (MGI Ref ID J:202453)
  • vision/eye phenotype
  • blepharitis
    • occasional blepharitis and eyelid dermatitis in some mice   (MGI Ref ID J:202453)
  • hematopoietic system phenotype
  • increased IgE level   (MGI Ref ID J:202453)
  • homeostasis/metabolism phenotype
  • impaired skin barrier function
    • increased transepidermal water loss   (MGI Ref ID J:202453)

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

Tmem79ma/Tmem79ma

        involves: CBA/CaGr
  • integument phenotype
  • abnormal coat appearance   (MGI Ref ID J:24772)
    • alopecia
      • hairs break leading to variable degrees of baldness as mice age   (MGI Ref ID J:24772)
    • matted coat
      • the phenotype is obvious by 4 weeks of age, especially on the back and flanks where groups of hairs are matted at tips to form clumps   (MGI Ref ID J:24772)
      • hair does not lie flat   (MGI Ref ID J:24772)
  • abnormal hair cycle
    • there is no significant difference in the lengths of the first and second hair generations   (MGI Ref ID J:12995)
    • the third hair generation was shorter than normal and likely due to friction on skin exposed by progressive hair-loss   (MGI Ref ID J:12995)
  • abnormal hair shaft morphology   (MGI Ref ID J:12995)
    • abnormal hair cuticle
      • cuticle shown to be permeable using fluorescent markers   (MGI Ref ID J:12995)
      • abnormal distribution of S-S linkage structure inferred as causal from experiments on normal cuticle   (MGI Ref ID J:12995)

Tmem79ma/Tmem79ma

        involves: C57BL/Gr * CBA/CaGr
  • pigmentation phenotype
  • darkened coat color
    • the matted hair exposes the black basal part of agouti hair, making the coat appear russet rather than black however there is no affect on pigment other than that found in the normal ageing process in C57 black mice   (MGI Ref ID J:12996)
    • the timing of changes in the coat color indicates early ageing in mutant mice   (MGI Ref ID J:12996)
  • integument phenotype
  • abnormal coat appearance
    • areas of small clumps contribute to a rough appearance   (MGI Ref ID J:12996)
    • abnormal hair growth
      • hairs are brittle and tend to split longitudinally   (MGI Ref ID J:12996)
      • alopecia
        • belly and head are rarely affected   (MGI Ref ID J:12996)
        • there is variable loss over the back and flanks due to rubbing on environmental surfaces   (MGI Ref ID J:12996)
        • baldness results from breakage above the skin rather than from patchy hair loss or failure of hairto regrow after molting   (MGI Ref ID J:12996)
    • darkened coat color
      • the matted hair exposes the black basal part of agouti hair, making the coat appear russet rather than black however there is no affect on pigment other than that found in the normal ageing process in C57 black mice   (MGI Ref ID J:12996)
      • the timing of changes in the coat color indicates early ageing in mutant mice   (MGI Ref ID J:12996)
    • matted coat
      • largest clumps involve dorsal long hair where least density   (MGI Ref ID J:12996)
      • areas of small clumps contribute to a rough appearance   (MGI Ref ID J:12996)
      • clumping is an outcome of grooming, saliva adhering distal hair shafts   (MGI Ref ID J:12996)

Tmem79ma/Tmem79ma

        involves: C57BL/6JJcl * CBA/CaGr
  • integument phenotype
  • abnormal epidermis stratum corneum morphology
    • impaired formation wit less resistance to physical external stress in a tape stripping test   (MGI Ref ID J:202316)
  • acanthosis
    • with leukocyte infiltration at 1 week prior to scratching behavior   (MGI Ref ID J:202316)
  • dermatitis
    • spontaneous dermatitis with scratching behavior   (MGI Ref ID J:202316)
    • however, dermatitis is rescued by transgenic expression of the wild-type gene   (MGI Ref ID J:202316)
  • impaired skin barrier function
    • increased transepidermal water loss and lower stratum corneum hydration   (MGI Ref ID J:202316)
  • matted coat   (MGI Ref ID J:202316)
  • immune system phenotype
  • dermatitis
    • spontaneous dermatitis with scratching behavior   (MGI Ref ID J:202316)
    • however, dermatitis is rescued by transgenic expression of the wild-type gene   (MGI Ref ID J:202316)
  • behavior/neurological phenotype
  • excessive scratching
    • spontaneous dermatitis with scratching behavior   (MGI Ref ID J:202316)
  • homeostasis/metabolism phenotype
  • impaired skin barrier function
    • increased transepidermal water loss and lower stratum corneum hydration   (MGI Ref ID J:202316)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Tmem79ma related

Dermatology Research
Skin and Hair Texture Defects

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Tmem79ma
Allele Name matted
Allele Type Spontaneous
Common Name(s) ma; matted;
Strain of OriginCBA/CaGr
Gene Symbol and Name Tmem79, transmembrane protein 79
Chromosome 3
Gene Common Name(s) 2310042N02Rik; 2310074C17Rik; MATT; RGD1309886; RIKEN cDNA 2310042N02 gene; RIKEN cDNA 2310074C17 gene; ma; matted; mattrin;
Molecular Note A spontaneous C to G nonsense mutation that results in the substitution of a stop for a tyrosine at position 280 (Y280X). [MGI Ref ID J:202316] [MGI Ref ID J:202453]

Genotyping

Genotyping Information


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Additional References

Tmem79ma related

Hogan ME; King LE Jr; Sundberg JP. 1995. Defects of pelage hairs in 20 mouse mutations. J Invest Dermatol 104(5 Suppl):31S-32S. [PubMed: 7738386]  [MGI Ref ID J:25255]

Jarrett A; Spearman RI. 1957. The keratin defect and hair-cycle of a new mutant (matted) in the house-mouse. J Embryol Exp Morphol 5(1):103-110.  [MGI Ref ID J:12995]

Rice RH; Bradshaw KM; Durbin-Johnson BP; Rocke DM; Eigenheer RA; Phinney BS; Sundberg JP. 2012. Differentiating inbred mouse strains from each other and those with single gene mutations using hair proteomics. PLoS One 7(12):e51956. [PubMed: 23251662]  [MGI Ref ID J:195664]

Sasaki T; Shiohama A; Kubo A; Kawasaki H; Ishida-Yamamoto A; Yamada T; Hachiya T; Shimizu A; Okano H; Kudoh J; Amagai M. 2013. A homozygous nonsense mutation in the gene for Tmem79, a component for the lamellar granule secretory system, produces spontaneous eczema in an experimental model of atopic dermatitis. J Allergy Clin Immunol 132(5):1111-1120.e4. [PubMed: 24060273]  [MGI Ref ID J:202316]

Saunders SP; Goh CS; Brown SJ; Palmer CN; Porter RM; Cole C; Campbell LE; Gierlinski M; Barton GJ; Schneider G; Balmain A; Prescott AR; Weidinger S; Baurecht H; Kabesch M; Gieger C; Lee YA; Tavendale R; Mukhopadhyay S; Turner SW; Madhok VB; Sullivan FM; Relton C; Burn J; Meggitt S; Smith CH; Allen MA; Barker JN; Reynolds NJ; Cordell HJ; Irvine AD; McLean WH; Sandilands A; Fallon PG. 2013. Tmem79/Matt is the matted mouse gene and is a predisposing gene for atopic dermatitis in human subjects. J Allergy Clin Immunol 132(5):1121-9. [PubMed: 24084074]  [MGI Ref ID J:202453]

Savinko T; Matikainen S; Saarialho-Kere U; Lehto M; Wang G; Lehtimaki S; Karisola P; Reunala T; Wolff H; Lauerma A; Alenius H. 2012. IL-33 and ST2 in atopic dermatitis: expression profiles and modulation by triggering factors. J Invest Dermatol 132(5):1392-400. [PubMed: 22277940]  [MGI Ref ID J:184634]

Searle AG; Spearman R. 1954. Matted (symbol ma) Mouse News Lett 11:29.  [MGI Ref ID J:24772]

Searle AG; Spearman RI. 1957. 'Matted', a new hair-mutant in the house-mouse: genetics and morphology. J Embryol Exp Morphol 5(1):93-102.  [MGI Ref ID J:12996]

Sundberg JP (ed.). 1994. Handbook of Mouse Mutations with Skin and Hair Abnormalities: Animal Models and Biomedical Tools. In: Handbook of Mouse Mutations with Skin and Hair Abnormalities: Animal Models and Biomedical Tools. CRC Press, Boca Raton.  [MGI Ref ID J:30359]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $3300.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $4290.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Control Information

  Control
   Untyped from the colony
   000664 C57BL/6J
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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