Strain Name:

B6.D-Tyrp1b Dock7m/J

Stock Number:

000027

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Availability:

Cryopreserved - Ready for recovery

Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Former Names B6.D-Tyrp1b m/J    (Changed: 28-APR-09 )
Type Congenic; Mutant Strain;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Additional information on Congenic nomenclature.
Specieslaboratory mouse
Background Strain C57BL/6J
Donor Strain Dock7m, DBA/J; Tyrp1b, DBA/J
GenerationN42p
Generation Definitions

Description
The recessive misty mutation causes a mild dilution of coat color and on certain backgrounds a white tail tip often accompanied by a belly spot. Melanocytes from Dock7m/Dock7m mice have a highly dendritic shape, show deficient proliferation in culture and have much more melanin content. Fewer melanoblasts are found in primary cultures from Dock7m/Dock7m mice than from wildtype controls. Between two and five weeks of age, Dock7m/Dock7m mice are smaller than controls. At 35 days of age they are shorter, weigh 15% less on average, and have less inguinal adipose mass than controls. Misty homozygotes completely lack brown fat. Although platelet count, seratonin content and ATP content are normal, there is increased bleed time and reduced platelet AD levels in Dock7m/Dock7m homozygotes. (Woolley, 1941 and 1945; Truett et al., 1998; Sviderskaya et al., 1998)

Related Strains

View Strains carrying   Dock7m     (8 strains)

View Strains carrying   Tyrp1b     (10 strains)

Strains carrying other alleles of Tyrp1
000957   AKXD28/TyJ
000093   B6.B10(D1)-Tyrp1b-c/J
008684   B6.Cg-Rag1tm1Mom Tyrp1B-w Tg(Tcra,Tcrb)9Rest/J
017764   B6Ei.LT-Y(IsXPAR;Y)Ei Tyrp1B-lt/EiJ
000068   C57BL/6J-Tyrp1b-J/J
000671   DBA/2J
006252   LT/SvEiJ
002142   STOCK 11R30m/J
000594   STOCK T(2;8)26H a/T(2;8)26H a Tyrp1+/Tyrp1b/J
View Strains carrying other alleles of Tyrp1     (9 strains)

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
Models with phenotypic similarity to human diseases where etiology is unknown or involving genes where ortholog is unknown.
Storage Pool Platelet Disease
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested.
Albinism, Oculocutaneous, Type III; OCA3   (TYRP1)
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

Dock7m/Dock7m

        B6.D(Cg)-Dock7m
  • adipose tissue phenotype
  • abnormal brown adipose tissue amount
    • appears to be completely absent in neonatal mice   (MGI Ref ID J:45425)
  • decreased white adipose tissue amount
    • mice have 21% less inguinal adipose mass   (MGI Ref ID J:48831)
  • growth/size/body phenotype
  • decreased body length
    • mutants are 8% shorter   (MGI Ref ID J:48831)
  • decreased body weight
    • mutants weigh 15% less   (MGI Ref ID J:48831)
  • hematopoietic system phenotype
  • decreased platelet ADP level
    • platelet ADP levels are low   (MGI Ref ID J:45425)
    • however, the platelet count, and platelet serotonin and ATP levels are normal   (MGI Ref ID J:45425)
  • homeostasis/metabolism phenotype
  • increased bleeding time   (MGI Ref ID J:45425)

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

Dock7m/Dock7m

        DBA/J
  • pigmentation phenotype
  • diluted coat color
    • coat color is not as diluted as that of homozygous dilute (Myo5ad) or homozygous leaden (Mlphln) mice   (MGI Ref ID J:311)
    • individual hairs have more cortical pigment than found in homozygous dilute or homozygous leaden mice   (MGI Ref ID J:311)
  • variable body spotting
    • white tail tip with or without a white belly spot   (MGI Ref ID J:311)
  • integument phenotype
  • diluted coat color
    • coat color is not as diluted as that of homozygous dilute (Myo5ad) or homozygous leaden (Mlphln) mice   (MGI Ref ID J:311)
    • individual hairs have more cortical pigment than found in homozygous dilute or homozygous leaden mice   (MGI Ref ID J:311)
  • variable body spotting
    • white tail tip with or without a white belly spot   (MGI Ref ID J:311)

Tyrp1b/Tyrp1b

        B6.D2-Tyrp1b
  • vision/eye phenotype
  • abnormal iris morphology
    • mutants develop iris disease that is first noticeable at 6 months of age when a population of small phagocytic clump cells began to be discernible across the iris surface   (MGI Ref ID J:128215)
    • with age, the underlying vasculature becomes obscured, and irides appear increasingly coarse and atrophic, particularly at the pupil margin where a narrow white band of underlying tissue is exposed   (MGI Ref ID J:128215)
    • with advanced age, full-thickness iris holes occur, but rarely before 2 years of age   (MGI Ref ID J:128215)
    • iris atrophy
      • irises are normal at 1-6 months of age, however, after 6 months of age, eyes show a gradual atrophy of the iris stroma   (MGI Ref ID J:128215)

The following phenotype relates to a compound genotype created using this strain.
Contact JAX® Services jaxservices@jax.org for customized breeding options.

a/a Tyrp1b/Tyrp1b

        involves: C57BL/6J
  • pigmentation phenotype
  • abnormal melanosome morphology
    • reorganization of fibrillar melanosomes into particulate melanin granules, such that 20% of granules in the choroid are particulate   (MGI Ref ID J:5346)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Dock7m related

Dermatology Research
Color and White Spotting Defects

Tyrp1b related

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Dock7m
Allele Name misty
Allele Type Spontaneous
Common Name(s) m;
Strain of OriginDBA/J
Gene Symbol and Name Dock7, dedicator of cytokinesis 7
Chromosome 4
Gene Common Name(s) 3110056M06Rik; EIEE23; Gm430; LOC242555; RIKEN cDNA 3110056M06 gene; ZIR2; gene model 430, (NCBI); m; mKIAA1771; misty;
Molecular Note Crosses between mice homozygous for misty and for moonlight, which mapped to overlapping critical regions on Chr 4, demonstrated failure of the two mutations to complement one another. Once moonlight had been identified as a mutation of Dock7 (Dock7mnlt), sequence analysis of this gene from misty mice revealed a retrotransposon LTR insertion following nucleotide 2045 (numbering from the A of the transcription initiation codon) that interrupts exon 18 and shifts the reading frame after codon 682 so that ten incorrect amino acids are incorporated into the protein before its premature termination. [MGI Ref ID J:146458]
 
Allele Symbol Tyrp1b
Allele Name brown
Allele Type Spontaneous
Common Name(s) b;
Strain of Originold mutant of the mouse fancy
Gene Symbol and Name Tyrp1, tyrosinase-related protein 1
Chromosome 4
Gene Common Name(s) B; CAS2; CATB; GP75; OCA3; TRP; TRP-1; TRP1; TYRP; Tyrp; b; b-PROTEIN; brown; iris stromal atrophy; isa; tyrosinase-related protein;
Molecular Note A G-to-A transition point mutation at position 329 was shown by revertant analysis to be responsible for the mutant phenotype seen in the brown mutant. This mutation is predicted to change a cysteine residue to a tyrosine in the encoded protein. Three other point mutations in the brown sequence were identified, but do not contribute to the mutant phenotype. [MGI Ref ID J:44435]

Genotyping

Genotyping Information


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Additional References

Fiedorek FT Jr; Kay ES. 1994. Mapping of PCR-based markers for mouse chromosome 4 on a backcross penetrant for the misty (m) mutation. Mamm Genome 5(8):479-85. [PubMed: 7949731]  [MGI Ref ID J:20039]

Sviderskaya EV; Novak EK; Swank RT; Bennett DC. 1998. The murine misty mutation: phenotypic effects on melanocytes, platelets and brown fat. Genetics 148(1):381-90. [PubMed: 9475748]  [MGI Ref ID J:45425]

Truett GE; Tempelman RJ; Walker JA; Wilson JK. 1998. Misty (m) affects growth traits. Am J Physiol 275(1 Pt 2):R29-32. [PubMed: 9688956]  [MGI Ref ID J:48831]

Dock7m related

Abe H; Uchida T; Hara A; Mizukami H; Komiya K; Koike M; Shigihara N; Toyofuku Y; Ogihara T; Uchiyama Y; Yagihashi S; Fujitani Y; Watada H. 2013. Exendin-4 improves beta-cell function in autophagy-deficient beta-cells. Endocrinology 154(12):4512-24. [PubMed: 24105478]  [MGI Ref ID J:205147]

Akasaka Y; Tsunoda M; Ogata T; Ide T; Murakami K. 2010. Direct evidence for leptin-induced lipid oxidation independent of long-form leptin receptor. Biochim Biophys Acta 1801(10):1115-22. [PubMed: 20601111]  [MGI Ref ID J:165456]

Alipio Z; Liao W; Roemer EJ; Waner M; Fink LM; Ward DC; Ma Y. 2010. Reversal of hyperglycemia in diabetic mouse models using induced-pluripotent stem (iPS)-derived pancreatic beta-like cells. Proc Natl Acad Sci U S A 107(30):13426-31. [PubMed: 20616080]  [MGI Ref ID J:162403]

Banks AS; Kon N; Knight C; Matsumoto M; Gutierrez-Juarez R; Rossetti L; Gu W; Accili D. 2008. SirT1 gain of function increases energy efficiency and prevents diabetes in mice. Cell Metab 8(4):333-41. [PubMed: 18840364]  [MGI Ref ID J:143422]

Bermudez DM; Herdrich BJ; Xu J; Lind R; Beason DP; Mitchell ME; Soslowsky LJ; Liechty KW. 2011. Impaired biomechanical properties of diabetic skin implications in pathogenesis of diabetic wound complications. Am J Pathol 178(5):2215-23. [PubMed: 21514435]  [MGI Ref ID J:171585]

Blasius AL; Brandl K; Crozat K; Xia Y; Khovananth K; Krebs P; Smart NG; Zampolli A; Ruggeri ZM; Beutler BA. 2009. Mice with mutations of Dock7 have generalized hypopigmentation and white-spotting but show normal neurological function. Proc Natl Acad Sci U S A 106(8):2706-11. [PubMed: 19202056]  [MGI Ref ID J:146458]

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Eller P; Eller K; Kirsch AH; Patsch JJ; Wolf AM; Tagwerker A; Stanzl U; Kaindl R; Kahlenberg V; Mayer G; Patsch JR; Rosenkranz AR. 2011. A murine model of phosphate nephropathy. Am J Pathol 178(5):1999-2006. [PubMed: 21514417]  [MGI Ref ID J:171593]

Flach RJ; Qin H; Zhang L; Bennett AM. 2011. Loss of mitogen-activated protein kinase phosphatase-1 protects from hepatic steatosis by repression of cell death-inducing DNA fragmentation factor A (DFFA)-like effector C (CIDEC)/fat-specific protein 27. J Biol Chem 286(25):22195-202. [PubMed: 21521693]  [MGI Ref ID J:174820]

Hamilton RT; Bhattacharya A; Walsh ME; Shi Y; Wei R; Zhang Y; Rodriguez KA; Buffenstein R; Chaudhuri AR; Van Remmen H. 2013. Elevated protein carbonylation, and misfolding in sciatic nerve from db/db and Sod1(-/-) mice: plausible link between oxidative stress and demyelination. PLoS One 8(6):e65725. [PubMed: 23750273]  [MGI Ref ID J:204258]

Iwakura H; Akamizu T; Ariyasu H; Irako T; Hosoda K; Nakao K; Kangawa K. 2007. Effects of ghrelin administration on decreased growth hormone status in obese animals. Am J Physiol Endocrinol Metab 293(3):E819-25. [PubMed: 17595213]  [MGI Ref ID J:125421]

Jung YJ; Choi HJ; Lee JE; Lee AS; Kang KP; Lee S; Park SK; Park TS; Jin HY; Lee SY; Kim DH; Kim W. 2012. The effects of designed angiopoietin-1 variant on lipid droplet diameter, vascular endothelial cell density and metabolic parameters in diabetic db/db mice. Biochem Biophys Res Commun 420(3):498-504. [PubMed: 22430141]  [MGI Ref ID J:183490]

Kanda Y; Shimoda M; Hamamoto S; Tawaramoto K; Kawasaki F; Hashiramoto M; Nakashima K; Matsuki M; Kaku K. 2010. Molecular mechanism by which pioglitazone preserves pancreatic beta-cells in obese diabetic mice: evidence for acute and chronic actions as a PPARgamma agonist. Am J Physiol Endocrinol Metab 298(2):E278-86. [PubMed: 19920213]  [MGI Ref ID J:170065]

Lee Y; Dominy JE; Choi YJ; Jurczak M; Tolliday N; Camporez JP; Chim H; Lim JH; Ruan HB; Yang X; Vazquez F; Sicinski P; Shulman GI; Puigserver P. 2014. Cyclin D1-Cdk4 controls glucose metabolism independently of cell cycle progression. Nature 510(7506):547-51. [PubMed: 24870244]  [MGI Ref ID J:213271]

Li M; Wang X; Aa J; Qin W; Zha W; Ge Y; Liu L; Zheng T; Cao B; Shi J; Zhao C; Wang X; Yu X; Wang G; Liu Z. 2013. GC/TOFMS analysis of metabolites in serum and urine reveals metabolic perturbation of TCA cycle in db/db mice involved in diabetic nephropathy. Am J Physiol Renal Physiol 304(11):F1317-24. [PubMed: 23467425]  [MGI Ref ID J:197264]

Loeffler I; Ruster C; Franke S; Liebisch M; Wolf G. 2013. Erythropoietin ameliorates podocyte injury in advanced diabetic nephropathy in the db/db mouse. Am J Physiol Renal Physiol 305(6):F911-8. [PubMed: 23825071]  [MGI Ref ID J:200934]

Mazagova M; Buikema H; Landheer SW; Vavrinec P; Buiten Av; Henning RH; Deelman LE. 2013. Growth differentiation factor 15 impairs aortic contractile and relaxing function through altered caveolar signaling of the endothelium. Am J Physiol Heart Circ Physiol 304(5):H709-18. [PubMed: 23262134]  [MGI Ref ID J:194601]

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Neuhofer A; Zeyda M; Mascher D; Itariu BK; Murano I; Leitner L; Hochbrugger EE; Fraisl P; Cinti S; Serhan CN; Stulnig TM. 2013. Impaired local production of proresolving lipid mediators in obesity and 17-HDHA as a potential treatment for obesity-associated inflammation. Diabetes 62(6):1945-56. [PubMed: 23349501]  [MGI Ref ID J:208560]

Nuno DW; Harrod JS; Lamping KG. 2009. Sex-dependent differences in Rho activation contribute to contractile dysfunction in type 2 diabetic mice. Am J Physiol Heart Circ Physiol 297(4):H1469-77. [PubMed: 19666843]  [MGI Ref ID J:154218]

O'Neill CM; Lu C; Corbin KL; Sharma PR; Dula SB; Carter JD; Ramadan JW; Xin W; Lee JK; Nunemaker CS. 2013. Circulating levels of IL-1B+IL-6 cause ER stress and dysfunction in islets from prediabetic male mice. Endocrinology 154(9):3077-88. [PubMed: 23836031]  [MGI Ref ID J:202248]

Olmsted-Davis E; Gannon FH; Ozen M; Ittmann MM; Gugala Z; Hipp JA; Moran KM; Fouletier-Dilling CM; Schumara-Martin S; Lindsey RW; Heggeness MH; Brenner MK; Davis AR. 2007. Hypoxic adipocytes pattern early heterotopic bone formation. Am J Pathol 170(2):620-32. [PubMed: 17255330]  [MGI Ref ID J:117897]

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Sviderskaya EV; Novak EK; Swank RT; Bennett DC. 1998. The murine misty mutation: phenotypic effects on melanocytes, platelets and brown fat. Genetics 148(1):381-90. [PubMed: 9475748]  [MGI Ref ID J:45425]

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Velmurugan GV; White C. 2012. Calcium homeostasis in vascular smooth muscle cells is altered in type 2 diabetes by Bcl-2 protein modulation of InsP3R calcium release channels. Am J Physiol Heart Circ Physiol 302(1):H124-34. [PubMed: 22037186]  [MGI Ref ID J:181575]

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Tyrp1b related

Anderson MG; Libby RT; Mao M; Cosma IM; Wilson LA; Smith RS; John SW. 2006. Genetic context determines susceptibility to intraocular pressure elevation in a mouse pigmentary glaucoma. BMC Biol 4:20. [PubMed: 16827931]  [MGI Ref ID J:128215]

Anderson MG; Nair KS; Amonoo LA; Mehalow A; Trantow CM; Masli S; John SW. 2008. GpnmbR150X allele must be present in bone marrow derived cells to mediate DBA/2J glaucoma. BMC Genet 9:30. [PubMed: 18402690]  [MGI Ref ID J:134670]

Barabas P; Huang W; Chen H; Koehler CL; Howell G; John SW; Tian N; Renteria RC; Krizaj D. 2011. Missing optomotor head-turning reflex in the DBA/2J mouse. Invest Ophthalmol Vis Sci 52(9):6766-73. [PubMed: 21757588]  [MGI Ref ID J:181395]

Brooks BP; Larson DM; Chan CC; Kjellstrom S; Smith RS; Crawford MA; Lamoreux L; Huizing M; Hess R; Jiao X; Hejtmancik JF; Maminishkis A; John SW; Bush R; Pavan WJ. 2007. Analysis of ocular hypopigmentation in Rab38cht/cht mice. Invest Ophthalmol Vis Sci 48(9):3905-13. [PubMed: 17724166]  [MGI Ref ID J:124886]

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Matheu A; Pantoja C; Efeyan A; Criado LM; Martin-Caballero J; Flores JM; Klatt P; Serrano M. 2004. Increased gene dosage of Ink4a/Arf results in cancer resistance and normal aging. Genes Dev 18(22):2736-46. [PubMed: 15520276]  [MGI Ref ID J:93879]

Medical Research Council (MRC) Harwell. 2012. Direct Data Submission 2012/03/01 MGI Direct Data Submission :.  [MGI Ref ID J:180879]

Moyer FH. 1966. Genetic variations in the fine structure and ontogeny of mouse melanin granules. Am Zool 6(1):43-66. [PubMed: 5902512]  [MGI Ref ID J:5001]

Murray WS. 1934. The breeding behavior of the dilute brown stock of mice (Little dba) Am J Cancer 20:573-593.  [MGI Ref ID J:2464]

Oak Ridge National Laboratory. 2005. Information obtained from the Oak Ridge National Laboratory Mutant Mouse Database (ORNL), Oak Ridge, TN Unpublished :.  [MGI Ref ID J:100221]

RIKEN BioResource Center/RIKEN Genomic Sciences Center. 2008. A Large Scale Mutagenesis Program in RIKEN GSC PhenoSITE, World Wide Web (URL: http://www.brc.riken.jp/lab/gsc/mouse/) :.  [MGI Ref ID J:133634]

RUSSELL ES. 1949. A quantitative histological study of the pigment found in the coat-color mutants of the house mouse; interdependence among the variable granule attributes. Genetics 34(2):133-45. [PubMed: 18117146]  [MGI Ref ID J:148461]

Raymond S; Jackson IJ. 1994. Molecular characterization of the mouse B<w> mutation causing premature melanocyte death - melanocytes and early development Genet Res 63(2):155 (Abstr).  [MGI Ref ID J:18590]

Rittenhouse E. 1968. Genetic effect on fine structure and development of pigment granules in mouse hair bulb melanocytes. I. The b and d loci. Dev Biol 17(4):351-65. [PubMed: 5650006]  [MGI Ref ID J:5068]

Russell ES. 1948. A Quantitative Histological Study of the Pigment Found in the Coat Color Mutants of the House Mouse. II. Estimates of the Total Volume of Pigment. Genetics 33(3):228-36. [PubMed: 17247280]  [MGI Ref ID J:148462]

Russell ES. 1946. A Quantitative Histological Study of the Pigment Found in the Coat-Color Mutants of the House Mouse. I. Variable Attributes of the Pigment Granules. Genetics 31(3):327-46. [PubMed: 17247200]  [MGI Ref ID J:148463]

Silvers WK. 1979. The Coat Colors of Mice; A Model for Mammalian Gene Action and Interaction. In: The Coat Colors of Mice. Springer-Verlag, New York.  [MGI Ref ID J:78801]

Smyth IM; Wilming L; Lee AW; Taylor MS; Gautier P; Barlow K; Wallis J; Martin S; Glithero R; Phillimore B; Pelan S; Andrew R; Holt K; Taylor R; McLaren S; Burton J; Bailey J; Sims S; Squares J; Plumb B; Joy A; Gibson R; Gilbert J; Hart E; Laird G; Loveland J; Mudge J; Steward C; Swarbreck D; Harrow J; North P; Leaves N; Greystrong J; Coppola M; Manjunath S; Campbell M; Smith M; Strachan G; Tofts C; Boal E; Cobley V; Hunter G; Kimberley C; Thomas D; Cave-Berry L; Weston P; Botcherby MR; White S; Edgar R; C. 2006. Genomic anatomy of the Tyrp1 (brown) deletion complex. Proc Natl Acad Sci U S A 103(10):3704-9. [PubMed: 16505357]  [MGI Ref ID J:107243]

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Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $3300.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $4290.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.


See Terms of Use tab for General Terms and Conditions


The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
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Terms of Use


General Terms and Conditions


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General inquiries regarding Terms of Use

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phone:207-288-6470

JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


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