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Strain Name:

B6.D-Tyrp1b m/J

Stock Number:

000027

Availability:

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General Terms and Conditions

Genes & Alleles   Tyrp1;   Tyrp1b;   m;

Product Information

Strain Details

Type JAX® GEMM® Strain - Congenic
Additional information on JAX® GEMM® Strains.
Type JAX® GEMM® Strain - Mutant Strain
Specieslaboratory mouse
Background Strain C57BL/6J
Donor Strain m, DBA/J; Tyrp1b , DBA/J
GenerationN42p

Strain Description
The recessive misty mutation causes a mild dilution of coat color and on certain backgrounds a white tail tip often accompanied by a belly spot. Melanocytes from m/m mice have a highly dendritic shape, show deficient proliferation in culture and have much more melanin content. Fewer melanoblasts are found in primary cultures from m/m mice than from wildtype controls. Between two and five weeks of age, m/m mice are smaller than controls. At 35 days of age they are shorter, weigh 15% less on average, and have less inguinal adipose mass than controls. Misty homozygotes completely lack brown fat. Although platelet count, seratonin content and ATP content are normal, there is increased bleed time and reduced platelet AD levels in m/m homozygotes. (Woolley, 1941 and 1945; Truett et al., 1998; Sviderskaya et al., 1998.)

Mammalian Phenotype Terms assigned by genotype

m/m

        B6.D2(Cg)-m
  • adipose tissue phenotype
  • abnormal brown adipose tissue amount (MGI Ref ID J:45425)
    • appeared to be completely absent in neonatal mice
  • decreased white adipose tissue amount (MGI Ref ID J:48831)
    • mice have 21% less inguinal adipose mass
  • growth/size phenotype
  • decreased body length (MGI Ref ID J:48831)
    • mutants are 8% shorter
  • decreased body weight (MGI Ref ID J:48831)
    • mutants weigh 15% less
  • hematopoietic system phenotype
  • platelet storage pool deficiency (MGI Ref ID J:45425)
    • platelet count, platelet serotonin and ATP levels normal
    • platelet ADP levels low
  • homeostasis/metabolism phenotype
  • increased bleeding time (MGI Ref ID J:45425)
  • platelet storage pool deficiency (MGI Ref ID J:45425)
    • platelet count, platelet serotonin and ATP levels normal
    • platelet ADP levels low

The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.

Tyrp1b/Tyrp1b

        B6.D2-Tyrp1b
  • vision/eye phenotype
  • abnormal iris morphology (MGI Ref ID J:128215)
    • mutants develop iris disease that is first noticeable at 6 months of age when a population of small phagocytic clump cells began to be discernible across the iris surface
    • with age, the underlying vasculature becomes obscured, and irides appear increasingly coarse and atrophic, particularly at the pupil margin where a narrow white band of underlying tissue is exposed
    • with advanced age, full-thickness iris holes occur, but rarely before 2 years of age
    • iris atrophy (MGI Ref ID J:128215)
      • irises are normal at 1-6 months of age, however, after 6 months of age, eyes show a gradual atrophy of the iris stroma

m/m

        DBA/J
  • pigmentation phenotype
  • diluted coat color (MGI Ref ID J:311)
    • coat color is not as diluted as that of homozygous dilute (Myo5ad) or homozygous leaden (Mlphln) mice
    • individual hairs have more cortical pigment than found in homozygous dilute or homozygous leaden mice
  • variable body spotting (MGI Ref ID J:311)
    • white tail tip with or without a white belly spot
  • skin/coat/nails phenotype
  • diluted coat color (MGI Ref ID J:311)
    • coat color is not as diluted as that of homozygous dilute (Myo5ad) or homozygous leaden (Mlphln) mice
    • individual hairs have more cortical pigment than found in homozygous dilute or homozygous leaden mice
  • variable body spotting (MGI Ref ID J:311)
    • white tail tip with or without a white belly spot

Gene & Allele Details

Allele Symbol Tyrp1b
Allele Name brown
Strain of OriginC57BL
Gene Symbol and Name Tyrp1, tyrosinase-related protein 1
Chromosome 4
Gene Common Name(s) B; CAS2; CATB; GP75; TRP; TRP-1; TRP1; TYRP; Tyrp; b; b-PROTEIN; brown; iris stromal atrophy; isa; tyrosinase-related protein;
General Note Tyrp1b, brown, recessive. This type mutant of the brown locus is an old mutation of the mouse fancy. The eumelanin of the hair and eyes is brown rather than black. The pigment granules also appear brown rather than black and are spheroid rather than ovoid in shape (J:12970). The fine structure of the developing pigment granules is fibrillar, like that of wild type mice, but the appearance of the mature granule may be more coarsely granular (J:5346, J:5001, J:5068). The granules incorporate twice as much 14C-tyrosine as normal (J:12173).
Molecular Note A G-to-A transition point mutation at position 329 was shown by revertant analysis to be responsible for the mutant phenotype seen in the brown mutant. This mutation is predicted to change a cysteine residue to a tyrosine in the encoded protein. Three other point mutations in the brown sequence were identified, but do not contribute to the mutant phenotype. [MGI Ref ID J:44435]
 
Allele Symbol m
Allele Name misty
Strain of OriginDBA/J

Genotyping Protocols

m (Misty)

Related Strains

Strains carrying   Tyrp1b allele
000004   ABP/LeJ
000571   B6.Cg-Whrnwi Tyrp1b/+ +/J
000670   DBA/1J
000265   MY/HuLeJ
001045   SI/Col Tyrp1b Dnahc11iv/J
000064   STOCK a Tyrp1b Sisi/J
002238   STOCK a Tyrp1b shmy/J
001432   STOCK a/a Tyrp1b sks/Tyrp1b +/J
000594   STOCK T(2;8)26H a/T(2;8)26H a Tyrp1+/Tyrp1b/J
001101   STOCK T(3;4)5Rk Tyrp1b/J
000274   TSJ/LeJ
View Strains carrying   Tyrp1b     (11 strains)

View Strains carrying   m     (9 strains)

Strains carrying other alleles of Tyrp1
000068   C57BL/6J-Tyrp1b-J/J
000093   C57BL/6J-Tyrp1b-cJ/J
000671   DBA/2J
003588   LT/SvEi
006252   LT/SvEiJ
002142   STOCK 11R30m/J
000594   STOCK T(2;8)26H a/T(2;8)26H a Tyrp1+/Tyrp1b/J
View Strains carrying other alleles of Tyrp1     (7 strains)

Additional Web Information

Congenic Nomenclature

Research Applications

This mouse can be used to support research in many areas including:

Tyrp1b related

Dermatology Research
Color and White Spotting Defects

Mouse/Human Gene Homologs
oculocutaneous albinism type III

m related

Dermatology Research
Color and White Spotting Defects

References

Additional References

Price and Supply Information

Strain Name: B6.D-Tyrp1b m/J
Stock Number: 000027

Price Details

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Supply Details

Standard SupplyRepository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information.
Supply Notes Cryorecovery - Standard.
The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two males and two females (two pairs) will be provided, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the delivery time to approximately 25 weeks. At least one member of each pair will be of known genotype and will carry the mutation if it is a mutant strain. Please note that pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Price represents a repository maintenance fee, which includes the cost of recovery of the strain from the cryopreservation resource and the periodic replacement of the frozen embryos used for recovery.

Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
One to two pairs will be recovered to establish a Dedicated Supply of mice. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services: Tel: 1-800-422-6423 or 1-207-288-5845; Email: jaxservices@jax.org.

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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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