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| The BXH set of RI strains is used in the genetic analysis of numerous complex or potentially complex physiologic phenotypes including differences in thyroid function (Graves' disease), bone mineral density, atherosclerosis and leukemia. The BXH set is derived from the C57BL/6J (Stock No. 000664) and C3H/HeJ (Stock No. 000659) progenitor strains. | |||||||||||||||
- Description
- Disease & phenotype
- Genes & alleles
- Genotyping
- Health & care
- References
- Pricing & purchasing
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Description
Strain Information
Former Names BXH-10/TyJ (Changed: 15-DEC-04 ) Type Recombinant Inbred (RI); Additional information on Recombinant Inbred Mice. Visit our online Nomenclature tutorial. Mating System Sibling x Sibling (Female x Male) 01-MAR-06 Species laboratory mouse RI progenitor C57BL/6J C3H/HeJ H2 Haplotype b Generation F19B4F109+33 (11-JUN-13)
Generation DefinitionsAppearance
black
Related Genotype: a/aDescription
The BXH set of RI strains is used in the genetic analysis of numerous complex or potentially complex physiologic phenotypes including differences in thyroid function (Graves' disease), bone mineral density, atherosclerosis and leukemia. A SNP data set is available through the Mouse Phenome Database for the BXH strains. Another BXH genotype data set consists of 472 MIT CA-repeat dinucleotide microsatellite markers that were typed at UTHSC from 1998 through 2000. The file is taken directly from Williams and colleagues (2001) without any significant modification in genotypes. This order of markers has been updated to conform to the March 2005 assembly of the mouse genome (Build 34 or UCSC mm6). The data set may be downloaded from the University of Tennessee Gene Network site .Development
The first 12 BXH recombinant inbred (RI) lines were generated and maintained at The Jackson Laboratory by Dr. Benjamin Taylor (labcode Ty) in 1969. Dr. Linda Siracusa at the Kimmell Cancer Center (labcode Kcc) generated a second set of 8 strains in 1995 by selecting for tyrosinase-negative albinos; a gene on the central part of chromosome (Chr) 7. BXH strains are derived from the C57BL/6J (Stock No. 000664) and C3H/HeJ (Stock No. 000659) progenitor strains. Several of the original strains are extinct. The Jackson Laboratory currently distributes 10 of the original Ty strains and 2 of the Kcc strains.
Related Strains
BXH Ty Strains
000039 BXH11/TyJ 000009 BXH14/TyJ 000033 BXH19/TyJ 000034 BXH2/TyJ 000011 BXH4/TyJ 000038 BXH6/TyJ 000014 BXH7/TyJ 000076 BXH8/TyJ 000008 BXH9/TyJ View BXH Ty Strains (9 strains)
000039 BXH11/TyJ 000009 BXH14/TyJ 000033 BXH19/TyJ 002632 BXH2/Ty1BedJ 000034 BXH2/TyJ 003784 BXH20/KccJ 003786 BXH22/KccJ 000011 BXH4/TyJ 000038 BXH6/TyJ 000014 BXH7/TyJ 000076 BXH8/TyJ 000008 BXH9/TyJ
000033 BXH19/TyJ 000011 BXH4/TyJ 000076 BXH8/TyJ 000008 BXH9/TyJ 000260 JGBF/LeJ 000072 JGBF/LeTyJ
000646 A/J 000651 BALB/cJ 000009 BXH14/TyJ 000038 BXH6/TyJ 000014 BXH7/TyJ 000665 C57BL/10J 000664 C57BL/6J 000669 C58/J
Phenotype
Phenotype Information
Mouse Phenome Database
Wellcome Trust Centre for Human Genetics: Mouse Recombinant Inbred Line (RIL) Genotype Data for BXH RI Line
This mouse can be used to support research in many areas including:
Research Tools
Genetics Research
Gene Mapping
Gene Mapping: Tools for QTL Mapping, Segregation and Linkage Analysis
Genes & Alleles
Gene & Allele Information provided by MGI
| Allele Symbol | MicrlR | ||
|---|---|---|---|
| Allele Name | responder | ||
| Allele Type | QTL | ||
| Strain of Origin | multiple strains | ||
| Gene Symbol and Name | Micrl, microwave induced increase in complement receptor B cells | ||
| Chromosome | 5 | ||
| General Note |
Carriers of this dominant QTL respond to microwave exposure with an increase in splenic C3 receptor-bearing B cells. The following inbred strains are homozygous for Micrl | ||
References
References provided by MGI
Selected Reference(s)
Williams RW; Gu J; Qi S; Lu L. 2001. The genetic structure of recombinant inbred mice: high-resolution consensus maps for complex trait analysis. Genome Biol 2(11):1-18. [PubMed: 11737945] [MGI Ref ID J:73062]
Additional References
MicrlR relatedSchlagel CJ; Ahmed A. 1982. Evidence for genetic control of microwave-induced augmentation of complement receptor-bearing B lymphocytes. J Immunol 129(4):1530-3. [PubMed: 6980940] [MGI Ref ID J:6835]
Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Room Number FGB27
Colony Maintenance
Mating System Sibling x Sibling (Female x Male) 01-MAR-06 Diet Information LabDiet® 5K54
Pricing and Purchasing
Pricing, Supply Level & Notes, Controls
| Pricing for USA, Canada and Mexico shipping destinations |
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Live Mice
Price per mouse (US dollars $) Gender Individual Mouse $125.00 Female or Male Standard Supply
Repository-Live.
Repository-Live represents an exclusive set of over 1500 unique mouse models across a vast array of research areas. Breeding colonies provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. If a Repository strain is not immediately available, then within 2 to 3 business days, you will receive an estimated availability timeframe for your inquiry or order along with various delivery options. Repository strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping. We will note and try to accommodate requests for specific ages of Repository strains but cannot guarantee provision of these strains at specific ages. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, please let us know.
| Pricing for International shipping destinations |
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Live Mice
Price per mouse (US dollars $) Gender Individual Mouse $162.50 Female or Male Standard Supply
Repository-Live.
Repository-Live represents an exclusive set of over 1500 unique mouse models across a vast array of research areas. Breeding colonies provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. If a Repository strain is not immediately available, then within 2 to 3 business days, you will receive an estimated availability timeframe for your inquiry or order along with various delivery options. Repository strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping. We will note and try to accommodate requests for specific ages of Repository strains but cannot guarantee provision of these strains at specific ages. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, please let us know.
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Standard Supply
Repository-Live.
Repository-Live represents an exclusive set of over 1500 unique mouse models across a vast array of research areas. Breeding colonies provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. If a Repository strain is not immediately available, then within 2 to 3 business days, you will receive an estimated availability timeframe for your inquiry or order along with various delivery options. Repository strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping. We will note and try to accommodate requests for specific ages of Repository strains but cannot guarantee provision of these strains at specific ages. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, please let us know.
General Supply Notes
- This strain is included in the Special Mutant Stock Resource collection.
- Genomic DNA is available for this strain from the Mouse DNA Resource.
Payment Terms and Conditions
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering Information
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