Strain Name: |
B6.D2-Tyrc-p/J |
|---|---|
Stock Number: |
000054 |
Availability: | Repository-Cryopreserved |
General Terms and Conditions |
| Genes & Alleles | Tyr; Tyrc-p; |
Product Information
Strain Details
Type JAX® GEMM® Strain - Congenic Additional information on JAX® GEMM® Strains. Type JAX® GEMM® Strain - Mutant Strain Species laboratory mouse Background Strain C57BL/6J Donor Strain DBA/2 Generation N23 Strain Description
The coat color of mice homozygous for the platinum mutation is nearly albino, cream colored, and these mice have pink eyes and a sheen to their coat. These homozygotes are lighter in color than chinchilla homozygotes despite having more tyrosinase activity in their cells. This is due to the altered subcellular localization of platinum tyrosinase. (Dickie M., 1966.)
Mammalian Phenotype Terms assigned by genotype |
Gene & Allele Details
| Allele Symbol | Tyrc-p | ||
|---|---|---|---|
| Allele Name | platinum | ||
| Strain of Origin | DBA/2J | ||
| Gene Symbol and Name | Tyr, tyrosinase | ||
| Chromosome | 7 | ||
| Gene Common Name(s) | C; OCA1A; OCAIA; SHEP3; albino; c; skc35; skin/coat color 35; | ||
| General Note | Tyrc-p, platinum. This mutation occurred in the DBA/2 strain and was found in an F1 hybrid with AKR/J at The Jackson Laboratory. Homozygotes are lighter than extreme dilution homozygotes and have pink eyes. Tyrc-p/Tyrc mice are intermediate between platinum and albino homozygotes (J:13442). Platinum homozygotes have almost as much tyrosinase in their skin as chinchilla homozygotes but a much larger proportion of it is in soluble form where it is not available for production of melanin in the melanosomes (J:6611). Platinum homozygotes, in fact, fail to produce a tyrsoinase isoform with a carboxy-terminal PEP7 epitope, which participates in a high molecular weight complex important to melanogenesis (J:13319). The mutation in the platinum allele was found to be an A to T substitution, changing a lysine residue at position 489 to a termination codon (J:30177). | ||
| Molecular Note | The mutation in the platinum allele was found to be an A to T substitution, changing a lysine residue at position 489 to a termination codon. [MGI Ref ID J:30177] | ||
Related Strains
Strains carrying other alleles of Tyr
View Strains carrying other alleles of Tyr (46 strains)
Additional Web Information
Congenic Nomenclature
Research Applications
This mouse can be used to support research in many areas including:Tyrc-p related
Dermatology Research
Color and White Spotting Defects
Mouse/Human Gene Homologs
albinism, tyrosine negative
References
Additional ReferencesPrice and Supply Information
| Strain Name: | B6.D2-Tyrc-p/J |
| Stock Number: | 000054 |
Price Details
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Supply Details
| Standard Supply | Repository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information. |
|---|---|
| Supply Notes |
Cryorecovery - Standard. The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two males and two females (two pairs) will be provided, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the delivery time to approximately 25 weeks. At least one member of each pair will be of known genotype and will carry the mutation if it is a mutant strain. Please note that pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Price represents a repository maintenance fee, which includes the cost of recovery of the strain from the cryopreservation resource and the periodic replacement of the frozen embryos used for recovery. Cryorecovery to establish a Dedicated Supply for greater quantities of mice. |
| Licensing | See General Terms and Conditions below |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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