Strain Name:

B6(Cg)-Tyrc-2J/J

Stock Number:

000058

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Availability:

Level 2


      Cell Line: B6(Cg)-Tyrc-2J/J-PRX-B6-albino #1 mES cells

Common Names: albino B6;     B6 albino;    
B6(Cg)-Tyrc-2J/J, or B6-albino mice, are C57BL/6J mice that carry a mutation in the tyrosinase gene. Pigment is completely absent from skin, hair and eyes in mice homozygous for Tyrc-2J. This unique characteristic makes these mice ideal for creation of novel strains with targeted mutations (gene knockouts). B6-albino mice are used to generate blastocysts that can be used for microinjection of genetically modified C57BL/6J embryonic stem cells. Following implantation and gestation, resulting offspring that are chimeric for the donor embryonic stem cells and the recipient blastocyst are easily identified by coat color. This allows an easy method to create knockout mice on the C57BL/6J genetic background.

Description

Strain Information

Former Names C57BL/6J-Tyrc-2J/J    (Changed: 28-FEB-07 )
Type Coisogenic; Mutant Strain; Spontaneous Mutation;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Mating SystemHomozygote x Homozygote         (Female x Male)   17-MAR-06
Breeding Considerations This strain is a good breeder.
Specieslaboratory mouse
GenerationF48+51N3F4pN3F13 (17-SEP-12)
Generation Definitions

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Appearance
albino
Related Genotype: a/a Tyrc-2J/Tyrc-2J

Description
Mice homozygous for Tyrc-2J are phenotypically identical to homozygotes for the classic albino allele. Pigment is completely absent from skin, hair and eyes. While Tyr mRNA levels of Tyrc-2J homozygotes are similar to those of wild-type mice, there is virtually no tyrosinase protein present (Le Fur et al. 1996). Both homozygote and heterozygote mice are highly resistant to light damage and exhibit retinal degeneration (increased photoreceptor death) into young adulthood. Degeneration does not continue in adult mice (Bravo-Nuevo et al. 2004).

Development
Tyrc-2J arose in 1970 at The Jackson Laboratory on a C57BL/6J congenic strain carrying Tyrp1b (Chr 4) and ep (Chr 19) when that congenic was at generation N20. Tyrp1b and ep were eliminated from the Tyrc-2J line by further backcrossing to C57BL/6J (Lane 1973).

Control Information

  Control
   000664 C57BL/6J
 
  Considerations for Choosing Controls

Related Strains

View Strains carrying   Tyrc-2J     (7 strains)

Strains carrying other alleles of Tyr
000090   129S1/Sv-Oca2+ Tyr+ KitlSl-J/J
000091   129T1/Sv-Oca2+ Tyrc-ch Dnd1Ter/J
005445   A.B6 Tyr+-Cybanmf333/J
005012   A.B6 Tyr+-Myo5ad-l31J/J
002565   A.B6-Tyr+/J
001017   AKXD10/TyJ
000765   AKXD13/TyJ
000954   AKXD15/TyJ
000958   AKXD16/TyJ
001093   AKXD18/TyJ
001062   AKXD21/TyJ
000947   AKXD22/TyJ
000969   AKXD24/TyJ
000777   AKXD6/TyJ
000763   AKXD9/TyJ
000409   B10.129P-H1b Hbbd Tyrc Ea7a/(5M)oSnJ
000418   B10.129P-H1b Tyrc Hbbd/(5M)nSnJ
000432   B10.C-H1b Hbbd Tyrc/(41N)SnJ
000580   B10.D2/nSn-Tyrc-4J/J
000822   B6 x 129S1/SvEi Oca2+ Tyr+-Vsx2or-J/J
000578   B6 x STOCK Tyrc-ch Bmp5se +/+ Myo6sv/J
000383   B6.C-Tyrc H1b Hbbd/ByJ
013590   B6.Cg-Braftm1Mmcm Ptentm1Hwu Tg(Tyr-cre/ERT2)13Bos/BosJ
003819   B6.Cg-Per2tm1Brd Tyrc-Brd/J
007484   B6.Cg-Tyrc-2J Tg(Tyr)3412ARpw Tg(Sry-EGFP)92Ei/EiJ
000035   B6.Cg-Tyrc-J/J
000104   B6.Cg-Tyrc-h/J
012328   B6.Cg-Tg(Tyr-cre/ERT2)13Bos/J
000054   B6.D2-Tyrc-p/J
000899   C.B6-Tyr+ Hbbs/J
000339   C3H/HeJ-Tyrc-9J/J
001294   C3H/HeJ-Tyrc-a/J
001002   C57BL/10SnJ-Tyrc-11J/J
012257   CB6-Tg(Tyr-TAg)BJjw/Mmjax
001006   CBA/J-Tyrc-10J/J
000657   CE/J
000619   FS/EiJ
004624   FVB.129P2-Pde6b+ Tyrc-ch Fmr1tm1Cgr/J
004828   FVB.129P2-Pde6b+ Tyrc-ch/AntJ
007483   FVB.Cg-Tg(Tyr)3412ARpw Tg(Sry-EGFP)92Ei/EiJ
000494   J.Cg-Oca2+ Tyr+ Lystbg/J
002281   NFS.C58-Tyr+/J
004304   NOD.CBALs-Tyr+/LtJ
000271   SH1/LeJ
001759   STOCK A Tyrc Sha/J
000306   STOCK Dll3pu + Tyrc-ch/+ Oca2p Tyrc-ch/J
018129   STOCK Fah1R Tyrc/RJ
000006   STOCK Hk Tyrc/J
000206   STOCK a/a Tyrc-h/J
View Strains carrying other alleles of Tyr     (49 strains)

Additional Web Information

JAX® NOTES, Fall 2003; 491. Use of Albino B6 (C57BL/6J-Tyrc-2J) Mice as Blastocyst Hosts for B6-derived ES Cells

Phenotype

Phenotype Information

View Phenotypic Data

Phenotypic Data
Mouse Phenome Database
View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Model with phenotypic similarity to human disease where etiologies involve orthologs. Human genes are associated with this disease. Orthologs of those genes appear in the mouse genotype(s).
Albinism, Oculocutaneous, Type IA; OCA1A
- Model with phenotypic similarity to human disease where etiologies are distinct. Human genes are associated with this disease. Orthologs of these genes do not appear in the mouse genotype(s).
Glaucoma 3, Primary Congenital, A; GLC3A
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested.
Albinism, Ocular, with Sensorineural Deafness   (TYR)
Albinism, Oculocutaneous, Type IB; OCA1B   (TYR)
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

Tyrc-2J/Tyrc-2J

        B6(Cg)-Tyrc-2J/J
  • pigmentation phenotype
  • abnormal melanosome morphology
    • absence of pigment in melanosomes   (MGI Ref ID J:178454)
    • absent hair follicle melanin granules
      • forskolin treatment does not protect mice from UV effects; numbers of apoptotic epidermal keratinocytes are similar to those in vehicle-treated mutants   (MGI Ref ID J:6611)
  • absent coat pigmentation
    • albino coat   (MGI Ref ID J:27522)
    • nitisinone treatment has no effect on pigmentation   (MGI Ref ID J:178454)
  • absent skin pigmentation   (MGI Ref ID J:36008)
  • ocular albinism   (MGI Ref ID J:178454)
    • total iris albinism   (MGI Ref ID J:141035)
  • vision/eye phenotype
  • abnormal aqueous drainage system morphology
    • had mild focal angle developmental defects, whereas pigmented mice had no observed defects   (MGI Ref ID J:82280)
  • abnormal eye physiology
    • resistant to light damage as compared to albino BALB/cByJ   (MGI Ref ID J:99553)
    • abnormal eye electrophysiology
      • reduction in a-wave and b-wave amplitude in young adults as demonstrated by electroretinogram   (MGI Ref ID J:92276)
    • abnormal intraocular pressure
      • increased pressure as compared to pigmented C57BL/6J   (MGI Ref ID J:82879)
    • abnormal vision
      • dark-adapted threshold s are elevated (decreased sensitivity) in comparison to C57BL/6J   (MGI Ref ID J:99554)
  • abnormal retina morphology
    • increased total number of cells in temporal retina during E11-13   (MGI Ref ID J:77026)
    • sustained, early production of ipsilateral retinal ganglion cells up to E14   (MGI Ref ID J:77026)
    • increased surface area of temporal retina, as well as additional sectors during E11-13   (MGI Ref ID J:77026)
    • abnormal retinal ganglion layer morphology
      • beginning at E11 through E16, cells exhibit smaller size and abnormal packing and organization   (MGI Ref ID J:77026)
    • abnormal retinal photoreceptor morphology
      • mean synaptic ribbon length is decreased in comparison to C57BL/6J mean synaptic ribbon length is decreased in comparison to C57BL/6J   (MGI Ref ID J:99554)
      • decreased retinal photoreceptor cell number
        • increased apoptosis in outer nuclear layer during adulthood (2-12 months), then decreasing to control levels   (MGI Ref ID J:92276)
    • retinal degeneration   (MGI Ref ID J:92276)
  • ocular albinism   (MGI Ref ID J:178454)
    • total iris albinism   (MGI Ref ID J:141035)
  • nervous system phenotype
  • abnormal retinal photoreceptor morphology
    • mean synaptic ribbon length is decreased in comparison to C57BL/6J mean synaptic ribbon length is decreased in comparison to C57BL/6J   (MGI Ref ID J:99554)
    • decreased retinal photoreceptor cell number
      • increased apoptosis in outer nuclear layer during adulthood (2-12 months), then decreasing to control levels   (MGI Ref ID J:92276)
  • cellular phenotype
  • abnormal keratinocyte apoptosis   (MGI Ref ID J:112959)
  • increased cellular sensitivity to ionizing radiation
    • mice show dose-dependent DNA lesion formation (cyclobutane dimers) from UV-B exposure, but wild-type or forskolin-treated Mc1re mutants show little damage   (MGI Ref ID J:112959)
  • integument phenotype
  • abnormal keratinocyte apoptosis   (MGI Ref ID J:112959)
  • absent coat pigmentation
    • albino coat   (MGI Ref ID J:27522)
    • nitisinone treatment has no effect on pigmentation   (MGI Ref ID J:178454)
  • absent hair follicle melanin granules
    • forskolin treatment does not protect mice from UV effects; numbers of apoptotic epidermal keratinocytes are similar to those in vehicle-treated mutants   (MGI Ref ID J:6611)
  • absent skin pigmentation   (MGI Ref ID J:36008)

The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.

Tyrc-2J/Tyrc-2J

        involves: C57BL/6
  • pigmentation phenotype
  • absent skin pigmentation
    • mice lack pigmentation in the skin and eyes   (MGI Ref ID J:6611)
    • mice lack detectable amounts of melanin in the hairbulbs   (MGI Ref ID J:6611)
  • integument phenotype
  • absent skin pigmentation
    • mice lack pigmentation in the skin and eyes   (MGI Ref ID J:6611)
    • mice lack detectable amounts of melanin in the hairbulbs   (MGI Ref ID J:6611)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Research Tools
Genetics Research
      Mutagenesis and Transgenesis: Production of Transgenic Mice

Tyrc-2J related

Dermatology Research
Color and White Spotting Defects

Sensorineural Research
Retinal Degeneration

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Tyrc-2J
Allele Name albino 2 Jackson
Allele Type Spontaneous
Strain of OriginB6.Cg-Tyrp1 Hps1
Site of ExpressionExpressed in melanosomes
Gene Symbol and Name Tyr, tyrosinase
Chromosome 7
Gene Common Name(s) ATN; C; CMM8; OCA1; OCA1A; OCAIA; SHEP3; albino; c; skc35; skin/coat color 35;
Molecular Note This mutation has a G to T base change at nucleotide 291 resulting in an amino acid change from arginine to leucine at residue 77 which lies in the highly conserved DDRE sequence. Nucleotide 291 is at the alternative 5' splice donor site for exon 1 and this allele does not produce the 1a or 1b subset of tyrosinase transcripts but does produce a significant increase in 1c and 1d transcripts. Western blots of homozygous mutant skin extracts demostrate the nearly complete absence of the broad 76-84 kDa bandof glycosylated wild-type tyrosinase. No tyrosinase activity was found in hairbulb extracts from homozygous mice. [MGI Ref ID J:36008] [MGI Ref ID J:6611]

Genotyping

Genotyping Information

Genotyping Protocols

Tyrc-2J alternative 1, End Point Analysis
Tyrc-2J, Standard PCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Townsend D; Witkop CJ Jr; Mattson J. 1981. Tyrosinase subcellular distribution and kinetic parameters in wild type and C-locus mutant C57BL/6J mice. J Exp Zool 216(1):113-9. [PubMed: 6793688]  [MGI Ref ID J:6611]

Additional References

Bravo-Nuevo A; Walsh N; Stone J. 2004. Photoreceptor degeneration and loss of retinal function in the C57BL/6-C2J mouse. Invest Ophthalmol Vis Sci 45(6):2005-12. [PubMed: 15161869]  [MGI Ref ID J:92276]

Hofele K; Sedelis M; Auburger GW; Morgan S; Huston JP; Schwarting RK. 2001. Evidence for a dissociation between MPTP toxicity and tyrosinase activity based on congenic mouse strain susceptibility. Exp Neurol 168(1):116-22. [PubMed: 11170726]  [MGI Ref ID J:67792]

Kwon BS; Haq AK; Wakulchik M; Kestler D; Barton DE; Francke U; Lamoreux ML; Whitney JB 3rd; Halaban R. 1989. Isolation, chromosomal mapping, and expression of the mouse tyrosinase gene. J Invest Dermatol 93(5):589-94. [PubMed: 2507645]  [MGI Ref ID J:10058]

Kwon BS; Wakulchik M; Haq AK; Halaban R; Kestler D. 1988. Sequence analysis of mouse tyrosinase cDNA and the effect of melanotropin on its gene expression. Biochem Biophys Res Commun 153(3):1301-9. [PubMed: 3134020]  [MGI Ref ID J:9242]

Le Fur N; Kelsall SR; Mintz B. 1996. Base substitution at different alternative splice donor sites of the tyrosinase gene in murine albinism. Genomics 37(2):245-8. [PubMed: 8921397]  [MGI Ref ID J:36008]

Nusinowitz S; Nguyen L; Radu R; Kashani Z; Farber D; Danciger M. 2003. Electroretinographic evidence for altered phototransduction gain and slowed recovery from photobleaches in albino mice with a MET450 variant in RPE65. Exp Eye Res 77(5):627-38. [PubMed: 14550405]  [MGI Ref ID J:86186]

Porter S; Mintz B. 1991. Multiple alternatively spliced transcripts of the mouse tyrosinase-encoding gene. Gene 97(2):277-82. [PubMed: 1900251]  [MGI Ref ID J:11014]

Rikke BA; Simpson VJ; Montoliu L; Johnson TE. 2001. No effect of albinism on sedative-hypnotic sensitivity to ethanol and anesthetics. Alcohol Clin Exp Res 25(2):171-6. [PubMed: 11236829]  [MGI Ref ID J:68230]

Ruppert S; Muller G; Kwon B; Schutz G. 1988. Multiple transcripts of the mouse tyrosinase gene are generated by alternative splicing. EMBO J 7(9):2715-22. [PubMed: 2846281]  [MGI Ref ID J:9439]

Schuster-Gossler K; Lee AW; Lerner CP; Parker HJ; Dyer VW; Scott VE; Gossler A; Conover JC. 2001. Use of coisogenic host blastocysts for efficient establishment of germline chimeras with C57BL/6J ES cell lines. Biotechniques 31(5):1022-4, 1026. [PubMed: 11730008]  [MGI Ref ID J:144015]

Zurita E; Chagoyen M; Cantero M; Alonso R; Gonzalez-Neira A; Lopez-Jimenez A; Lopez-Moreno JA; Landel CP; Benitez J; Pazos F; Montoliu L. 2010. Genetic polymorphisms among C57BL/6 mouse inbred strains. Transgenic Res :. [PubMed: 20506040]  [MGI Ref ID J:160203]

Tyrc-2J related

Alur RP; Cox TA; Crawford MA; Gong X; Brooks BP. 2008. Optic nerve axon number in mouse is regulated by PAX2. J AAPOS 12(2):117-21. [PubMed: 18083586]  [MGI Ref ID J:172973]

Anderson MG; Hawes NL; Trantow CM; Chang B; John SW. 2008. Iris phenotypes and pigment dispersion caused by genes influencing pigmentation. Pigment Cell Melanoma Res 21(5):565-78. [PubMed: 18715234]  [MGI Ref ID J:141035]

Anderson MG; Libby RT; Mao M; Cosma IM; Wilson LA; Smith RS; John SW. 2006. Genetic context determines susceptibility to intraocular pressure elevation in a mouse pigmentary glaucoma. BMC Biol 4:20. [PubMed: 16827931]  [MGI Ref ID J:128215]

Balkema GW; Cusick K; Nguyen TH. 2001. Diurnal variation in synaptic ribbon length and visual threshold. Vis Neurosci 18(5):789-97. [PubMed: 11925014]  [MGI Ref ID J:99554]

Bravo-Nuevo A; Walsh N; Stone J. 2004. Photoreceptor degeneration and loss of retinal function in the C57BL/6-C2J mouse. Invest Ophthalmol Vis Sci 45(6):2005-12. [PubMed: 15161869]  [MGI Ref ID J:92276]

Cohen-Solal KA; Crespo-Carbone SM; Namkoong J; Mackason KR; Roberts KG; Reuhl KR; Chen S. 2002. Progressive appearance of pigmentation in amelanotic melanoma lesions. Pigment Cell Res 15(4):282-9. [PubMed: 12100494]  [MGI Ref ID J:77989]

Cortese K; Giordano F; Surace EM; Venturi C; Ballabio A; Tacchetti C; Marigo V. 2005. The ocular albinism type 1 (OA1) gene controls melanosome maturation and size. Invest Ophthalmol Vis Sci 46(12):4358-64. [PubMed: 16303920]  [MGI Ref ID J:103788]

D'Orazio JA; Nobuhisa T; Cui R; Arya M; Spry M; Wakamatsu K; Igras V; Kunisada T; Granter SR; Nishimura EK; Ito S; Fisher DE. 2006. Topical drug rescue strategy and skin protection based on the role of Mc1r in UV-induced tanning. Nature 443(7109):340-4. [PubMed: 16988713]  [MGI Ref ID J:112959]

Danciger M; Ogando D; Yang H; Matthes MT; Yu N; Ahern K; Yasumura D; Williams RW; Lavail MM. 2008. Genetic modifiers of retinal degeneration in the rd3 mouse. Invest Ophthalmol Vis Sci 49(7):2863-9. [PubMed: 18344445]  [MGI Ref ID J:136923]

Dentin R; Liu Y; Koo SH; Hedrick S; Vargas T; Heredia J; Yates J rd; Montminy M. 2007. Insulin modulates gluconeogenesis by inhibition of the coactivator TORC2. Nature 449(7160):366-9. [PubMed: 17805301]  [MGI Ref ID J:126351]

Eisenhofer G; Tian H; Holmes C; Matsunaga J; Roffler-Tarlov S; Hearing VJ. 2003. Tyrosinase: a developmentally specific major determinant of peripheral dopamine. FASEB J 17(10):1248-55. [PubMed: 12832289]  [MGI Ref ID J:119178]

Fetoni AR; Picciotti PM; Paludetti G; Troiani D. 2011. Pathogenesis of presbycusis in animal models: a review. Exp Gerontol 46(6):413-25. [PubMed: 21211561]  [MGI Ref ID J:186964]

Gibbs D; Cideciyan AV; Jacobson SG; Williams DS. 2009. Retinal pigment epithelium defects in humans and mice with mutations in MYO7A: imaging melanosome-specific autofluorescence. Invest Ophthalmol Vis Sci 50(9):4386-93. [PubMed: 19324852]  [MGI Ref ID J:154563]

Green EL. 1973. Albino-2J (c<2J>) Mouse News Lett 49:31.  [MGI Ref ID J:27522]

Iacovelli J; Zhao C; Wolkow N; Veldman P; Gollomp K; Ojha P; Lukinova N; King A; Feiner L; Esumi N; Zack DJ; Pierce EA; Vollrath D; Dunaief JL. 2011. Generation of Cre Transgenic Mice with Postnatal RPE-Specific Ocular Expression. Invest Ophthalmol Vis Sci 52(3):1378-83. [PubMed: 21212186]  [MGI Ref ID J:170522]

Imanishi Y; Sun W; Maeda T; Maeda A; Palczewski K. 2008. Retinyl ester homeostasis in the adipose differentiation-related protein-deficient retina. J Biol Chem 283(36):25091-102. [PubMed: 18606814]  [MGI Ref ID J:142021]

Johnson BA; Cole BS; Geisert EE; Ikeda S; Ikeda A. 2010. Tyrosinase is the modifier of retinoschisis in mice. Genetics 186(4):1337-44. [PubMed: 20876567]  [MGI Ref ID J:166949]

Katz ML; Wendt KD; Sanders DN. 2005. RPE65 gene mutation prevents development of autofluorescence in retinal pigment epithelial phagosomes. Mech Ageing Dev 126(4):513-21. [PubMed: 15722110]  [MGI Ref ID J:98275]

Kitamoto J; Libby RT; Gibbs D; Steel KP; Williams DS. 2005. Myosin VI is required for normal retinal function. Exp Eye Res 81(1):116-20. [PubMed: 15978262]  [MGI Ref ID J:134368]

Kiyama T; Li H; Gupta M; Lin YP; Chuang AZ; Otteson DC; Wang SW. 2012. Distinct neurogenic potential in the retinal margin and the pars plana of Mammalian eye. J Neurosci 32(37):12797-807. [PubMed: 22973003]  [MGI Ref ID J:187665]

LaVail MM; Gorrin GM; Repaci MA; Thomas LA; Ginsberg HM. 1987. Genetic regulation of light damage to photoreceptors. Invest Ophthalmol Vis Sci 28(7):1043-8. [PubMed: 3596986]  [MGI Ref ID J:99553]

Lammermann T; Afonso PV; Angermann BR; Wang JM; Kastenmuller W; Parent CA; Germain RN. 2013. Neutrophil swarms require LTB4 and integrins at sites of cell death in vivo. Nature 498(7454):371-5. [PubMed: 23708969]  [MGI Ref ID J:198733]

Lamoreux ML; Wakamatsu K; Ito S. 2001. Interaction of major coat color gene functions in mice as studied by chemical analysis of eumelanin and pheomelanin. Pigment Cell Res 14(1):23-31. [PubMed: 11277491]  [MGI Ref ID J:103803]

Le Fur N; Kelsall SR; Mintz B. 1996. Base substitution at different alternative splice donor sites of the tyrosinase gene in murine albinism. Genomics 37(2):245-8. [PubMed: 8921397]  [MGI Ref ID J:36008]

Lehman AL; Silvers WK; Puri N; Wakamatsu K; Ito S; Brilliant MH. 2000. The underwhite (uw) locus acts autonomously and reduces the production of melanin J Invest Dermatol 115(4):601-6. [PubMed: 10998130]  [MGI Ref ID J:64978]

Libby RT; Smith RS; Savinova OV; Zabaleta A; Martin JE; Gonzalez FJ; John SW. 2003. Modification of ocular defects in mouse developmental glaucoma models by tyrosinase. Science 299(5612):1578-81. [PubMed: 12624268]  [MGI Ref ID J:82280]

Liu X; Alli R; Steeves M; Nguyen P; Vogel P; Geiger TL. 2012. The T cell response to IL-10 alters cellular dynamics and paradoxically promotes central nervous system autoimmunity. J Immunol 189(2):669-78. [PubMed: 22711892]  [MGI Ref ID J:189797]

Mitra D; Luo X; Morgan A; Wang J; Hoang MP; Lo J; Guerrero CR; Lennerz JK; Mihm MC; Wargo JA; Robinson KC; Devi SP; Vanover JC; D'Orazio JA; McMahon M; Bosenberg MW; Haigis KM; Haber DA; Wang Y; Fisher DE. 2012. An ultraviolet-radiation-independent pathway to melanoma carcinogenesis in the red hair/fair skin background. Nature 491(7424):449-53. [PubMed: 23123854]  [MGI Ref ID J:189208]

Motohashi H; Hozawa K; Oshima T; Takeuchi T; Takasaka T. 1994. Dysgenesis of melanocytes and cochlear dysfunction in mutant microphthalmia (mi) mice. Hear Res 80(1):10-20. [PubMed: 7852195]  [MGI Ref ID J:21682]

Nishimura EK; Granter SR; Fisher DE. 2005. Mechanisms of hair graying: incomplete melanocyte stem cell maintenance in the niche. Science 307(5710):720-4. [PubMed: 15618488]  [MGI Ref ID J:96016]

Ohlemiller KK; Rice ME; Lett JM; Gagnon PM. 2009. Absence of strial melanin coincides with age-associated marginal cell loss and endocochlear potential decline. Hear Res 249(1-2):1-14. [PubMed: 19141317]  [MGI Ref ID J:145863]

Onojafe IF; Adams DR; Simeonov DR; Zhang J; Chan CC; Bernardini IM; Sergeev YV; Dolinska MB; Alur RP; Brilliant MH; Gahl WA; Brooks BP. 2011. Nitisinone improves eye and skin pigmentation defects in a mouse model of oculocutaneous albinism. J Clin Invest 121(10):3914-23. [PubMed: 21968110]  [MGI Ref ID J:178454]

Potter CS; Pruett ND; Kern MJ; Baybo MA; Godwin AR; Potter KA; Peterson RL; Sundberg JP; Awgulewitsch A. 2011. The nude mutant gene Foxn1 is a HOXC13 regulatory target during hair follicle and nail differentiation. J Invest Dermatol 131(4):828-37. [PubMed: 21191399]  [MGI Ref ID J:182085]

Rachel RA; Dolen G; Hayes NL; Lu A; Erskine L; Nowakowski RS; Mason CA. 2002. Spatiotemporal features of early neuronogenesis differ in wild-type and albino mouse retina. J Neurosci 22(11):4249-63. [PubMed: 12040030]  [MGI Ref ID J:77026]

Raven MA; Reese BE. 2002. Horizontal cell density and mosaic regularity in pigmented and albino mouse retina. J Comp Neurol 454(2):168-76. [PubMed: 12412141]  [MGI Ref ID J:126185]

Rikke BA; Simpson VJ; Montoliu L; Johnson TE. 2001. No effect of albinism on sedative-hypnotic sensitivity to ethanol and anesthetics. Alcohol Clin Exp Res 25(2):171-6. [PubMed: 11236829]  [MGI Ref ID J:68230]

Rizvi TA; Huang Y; Sidani A; Atit R; Largaespada DA; Boissy RE; Ratner N. 2002. A novel cytokine pathway suppresses glial cell melanogenesis after injury to adult nerve. J Neurosci 22(22):9831-40. [PubMed: 12427839]  [MGI Ref ID J:109211]

Robison WG Jr; Kuwabara T. 1976. Light-induced alterations of retinal pigment epithelium in black, albino, and beige mice. Exp Eye Res 22(5):549-57. [PubMed: 1278263]  [MGI Ref ID J:5656]

Rosenzweig HL; Kawaguchi T; Martin TM; Planck SR; Davey MP; Rosenbaum JT. 2009. Nucleotide oligomerization domain-2 (NOD2)-induced uveitis: dependence on IFN-gamma. Invest Ophthalmol Vis Sci 50(4):1739-45. [PubMed: 19098321]  [MGI Ref ID J:146921]

Rosenzweig HL; Martin TM; Jann MM; Planck SR; Davey MP; Kobayashi K; Flavell RA; Rosenbaum JT. 2008. NOD2, the gene responsible for familial granulomatous uveitis, in a mouse model of uveitis. Invest Ophthalmol Vis Sci 49(4):1518-24. [PubMed: 18385071]  [MGI Ref ID J:136140]

Savinova OV; Sugiyama F; Martin JE; Tomarev SI; Paigen BJ; Smith RS; John SW. 2001. Intraocular pressure in genetically distinct mice: an update and strain survey. BMC Genet 2(1):12. [PubMed: 11532192]  [MGI Ref ID J:82879]

Schuster-Gossler K; Lee AW; Lerner CP; Parker HJ; Dyer VW; Scott VE; Gossler A; Conover JC. 2001. Use of coisogenic host blastocysts for efficient establishment of germline chimeras with C57BL/6J ES cell lines. Biotechniques 31(5):1022-4, 1026. [PubMed: 11730008]  [MGI Ref ID J:144015]

Schwesinger C; Yee C; Rohan RM; Joussen AM; Fernandez A; Meyer TN; Poulaki V; Ma JJ; Redmond TM; Liu S; Adamis AP; D'Amato RJ. 2001. Intrachoroidal neovascularization in transgenic mice overexpressing vascular endothelial growth factor in the retinal pigment epithelium. Am J Pathol 158(3):1161-72. [PubMed: 11238064]  [MGI Ref ID J:133002]

Solodova E; Jablonska J; Weiss S; Lienenklaus S. 2011. Production of IFN-beta during Listeria monocytogenes infection is restricted to monocyte/macrophage lineage. PLoS One 6(4):e18543. [PubMed: 21494554]  [MGI Ref ID J:172226]

Svensson RU; Haverkamp JM; Thedens DR; Cohen MB; Ratliff TL; Henry MD. 2011. Slow disease progression in a C57BL/6 pten-deficient mouse model of prostate cancer. Am J Pathol 179(1):502-12. [PubMed: 21703427]  [MGI Ref ID J:173997]

Taft RA; Low BE; Byers SL; Murray SA; Kutny P; Wiles MV. 2013. The perfect host: a mouse host embryo facilitating more efficient germ line transmission of genetically modified embryonic stem cells. PLoS One 8(7):e67826. [PubMed: 23844102]  [MGI Ref ID J:204306]

Takeuchi S; Zhang W; Wakamatsu K; Ito S; Hearing VJ; Kraemer KH; Brash DE. 2004. Melanin acts as a potent UVB photosensitizer to cause an atypical mode of cell death in murine skin. Proc Natl Acad Sci U S A 101(42):15076-81. [PubMed: 15477596]  [MGI Ref ID J:93542]

Thiels E; Hoffman EK; Gorin MB. 2008. A reliable behavioral assay for the assessment of sustained photophobia in mice. Curr Eye Res 33(5):483-91. [PubMed: 18568886]  [MGI Ref ID J:139747]

Tinkum KL; Marpegan L; White LS; Sun J; Herzog ED; Piwnica-Worms D; Piwnica-Worms H. 2011. Bioluminescence Imaging Captures the Expression and Dynamics of Endogenous p21 Promoter Activity in Living Mice and Intact Cells. Mol Cell Biol 31(18):3759-72. [PubMed: 21791610]  [MGI Ref ID J:175772]

Waisberg M; Vickers BK; Yager SB; Lin CK; Pierce SK. 2012. Testing in mice the hypothesis that melanin is protective in malaria infections. PLoS One 7(1):e29493. [PubMed: 22242171]  [MGI Ref ID J:184147]

Whitney IE; Raven MA; Ciobanu DC; Williams RW; Reese BE. 2009. Multiple genes on chromosome 7 regulate dopaminergic amacrine cell number in the mouse retina. Invest Ophthalmol Vis Sci 50(5):1996-2003. [PubMed: 19168892]  [MGI Ref ID J:149703]

Xie T; Nguyen T; Hupe M; Wei ML. 2009. Multidrug resistance decreases with mutations of melanosomal regulatory genes. Cancer Res 69(3):992-9. [PubMed: 19155314]  [MGI Ref ID J:144973]

Young A; Powelson EB; Whitney IE; Raven MA; Nusinowitz S; Jiang M; Birnbaumer L; Reese BE; Farber DB. 2008. Involvement of OA1, an intracellular GPCR, and G alpha i3, its binding protein, in melanosomal biogenesis and optic pathway formation. Invest Ophthalmol Vis Sci 49(7):3245-52. [PubMed: 18378571]  [MGI Ref ID J:136897]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           AX6
Room Number           MP24
Room Number           RB10

Colony Maintenance

Mating SystemHomozygote x Homozygote         (Female x Male)   17-MAR-06
Breeding Considerations This strain is a good breeder.
Diet Information LabDiet® 5K52/5K67

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Live Mice

Weeks of AgePrice per mouse (US dollars $)GenderGenotypes Provided
3 weeks $26.90Female or MaleHomozygous for Tyrc-2J  
4 weeks $26.90Female or MaleHomozygous for Tyrc-2J  
5 weeks $26.90Female or MaleHomozygous for Tyrc-2J  
6 weeks $29.30Female or MaleHomozygous for Tyrc-2J  
7 weeks $31.60Female or MaleHomozygous for Tyrc-2J  
8 weeks $34.10Female or MaleHomozygous for Tyrc-2J  
9 weeks $36.35Female or MaleHomozygous for Tyrc-2J  
10 weeks $38.70Female or MaleHomozygous for Tyrc-2J  
11 weeks $41.15Female or MaleHomozygous for Tyrc-2J  
12 weeks $43.55Female or MaleHomozygous for Tyrc-2J  
Price per Pair (US dollars $)Pair Genotype
$58.60Homozygous for Tyrc-2J x Homozygous for Tyrc-2J  

Standard Supply

Level 2. Up to 100 mice. Larger quantities or custom orders arranged upon request.

Supply Notes

  • This strain is available from both the Bar Harbor, Maine and Sacramento, Calif. facilities.
  • Pair Pricing: Price may vary depending on the age of the males and females available for shipment. The price displayed is for a male and female at six weeks of age.
  • Shipped at a specific age in weeks. Mice at a precise age in days, littermates and retired breeders are also available.

JAX® Cells, Tissues & Products

Select the cell line of interest to go to the cell line data sheet
B6(Cg)-Tyrc-2J/J-PRX-B6-albino #1 mES cells
Pricing for International shipping destinations View USA Canada and Mexico Pricing

Live Mice

Weeks of AgePrice per mouse (US dollars $)GenderGenotypes Provided
3 weeks $35.00Female or MaleHomozygous for Tyrc-2J  
4 weeks $35.00Female or MaleHomozygous for Tyrc-2J  
5 weeks $35.00Female or MaleHomozygous for Tyrc-2J  
6 weeks $38.10Female or MaleHomozygous for Tyrc-2J  
7 weeks $41.10Female or MaleHomozygous for Tyrc-2J  
8 weeks $44.40Female or MaleHomozygous for Tyrc-2J  
9 weeks $47.30Female or MaleHomozygous for Tyrc-2J  
10 weeks $50.40Female or MaleHomozygous for Tyrc-2J  
11 weeks $53.50Female or MaleHomozygous for Tyrc-2J  
12 weeks $56.70Female or MaleHomozygous for Tyrc-2J  
Price per Pair (US dollars $)Pair Genotype
$76.20Homozygous for Tyrc-2J x Homozygous for Tyrc-2J  

Standard Supply

Level 2. Up to 100 mice. Larger quantities or custom orders arranged upon request.

Supply Notes

  • Pair Pricing: Price may vary depending on the age of the males and females available for shipment. The price displayed is for a male and female at six weeks of age.
  • Shipped at a specific age in weeks. Mice at a precise age in days, littermates and retired breeders are also available.

JAX® Cells, Tissues & Products

Select the cell line of interest to go to the cell line data sheet
B6(Cg)-Tyrc-2J/J-PRX-B6-albino #1 mES cells
View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Level 2. Up to 100 mice. Larger quantities or custom orders arranged upon request.

General Supply Notes



  •   

Control Information

  Control
   000664 C57BL/6J
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.


See Terms of Use tab for General Terms and Conditions


The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
Ordering Information
JAX® Mice
Surgical and Preconditioning Services
JAX® Services
Customer Services and Support
Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
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Terms of Use

Terms of Use


General Terms and Conditions


Contact information

General inquiries regarding Terms of Use

Contracts Administration

phone:207-288-6470

JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


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