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Strain Name:

C57BL/6J-Mc1re/J

Stock Number:

000060

Availability:

Repository-Cryopreserved

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General Terms and Conditions

Genes & Alleles   Mc1r;   Mc1re;

Product Information

Strain Details

Type JAX® GEMM® Strain - Coisogenic
Additional information on JAX® GEMM® Strains.
Type JAX® GEMM® Strain - Mutant Strain
Type JAX® GEMM® Strain - Spontaneous Mutation
Specieslaboratory mouse
GenerationN21p
Mammalian Phenotype Terms assigned by genotype

Mc1re/Mc1re

        C57BL/6J-Mc1re/J
  • pigmentation phenotype
  • abnormal melanogenesis (MGI Ref ID J:112959)
    • in mutants, no measurable UV-induced melanization is observed; forskolin application to the skin induces significant skin darkening
  • abnormal skin pigmentation (MGI Ref ID J:112959)
    • mice show no UV-induced detectable pigmentation changes, while wild type ears show grossly and microscopically detectable hyperpigmentation
  • skin/coat/nails phenotype
  • abnormal keratinocyte apoptosis (MGI Ref ID J:112959)
    • forskolin pre-treatment produces UV protection similar to wild type (black skinned) mice while untreated mutants are very UV-sensitive; untreated mice show formation of sunburn cells 24 hours after UV exposure
  • abnormal skin pigmentation (MGI Ref ID J:112959)
    • mice show no UV-induced detectable pigmentation changes, while wild type ears show grossly and microscopically detectable hyperpigmentation
  • cellular phenotype
  • increased cellular sensitivity to ionizing radiation (MGI Ref ID J:112959)

Mc1re/Mc1re

        C57BL/6
  • behavior/neurological phenotype
  • abnormal touch/ nociception (MGI Ref ID J:112815)
    • mutant females and males display reduced pain sensitivity
    • abnormal pain threshold (MGI Ref ID J:112815)
      • males display significantly higher latencies than females for the 49 degree water tail withdrawal test
    • analgesia (MGI Ref ID J:112815)
      • 6-10 week old females and males display increased analgesic responsiveness to morphine-6-glucuronide when challenged with thermal nociception
  • touch/vibrissae phenotype
  • abnormal touch/ nociception (MGI Ref ID J:112815)
    • mutant females and males display reduced pain sensitivity
    • abnormal pain threshold (MGI Ref ID J:112815)
      • males display significantly higher latencies than females for the 49 degree water tail withdrawal test
    • analgesia (MGI Ref ID J:112815)
      • 6-10 week old females and males display increased analgesic responsiveness to morphine-6-glucuronide when challenged with thermal nociception

Mc1re/Mc1re

        C57BL/6Ha
  • pigmentation phenotype
  • abnormal coat color (MGI Ref ID J:5110)
    • abnormal hair follicle melanogenesis (MGI Ref ID J:5563)
      • neural tube-skin recombination grafting technique demonstrates that phaeomelanin (yellow coat color) is controlled by melanocyte genotype; not skin genotype
    • yellow coat color (MGI Ref ID J:5110)
      • the clear yellow color accentuates the normal black eye color
      • the entire length of the hair is yellow
  • skin/coat/nails phenotype
  • abnormal coat color (MGI Ref ID J:5110)
    • abnormal hair follicle melanogenesis (MGI Ref ID J:5563)
      • neural tube-skin recombination grafting technique demonstrates that phaeomelanin (yellow coat color) is controlled by melanocyte genotype; not skin genotype
    • yellow coat color (MGI Ref ID J:5110)
      • the clear yellow color accentuates the normal black eye color
      • the entire length of the hair is yellow

Gene & Allele Details

Allele Symbol Mc1re
Allele Name recessive yellow
Common Name(s) e;
Strain of OriginC57BL/6Ha
Gene Symbol and Name Mc1r, melanocortin 1 receptor
Chromosome 8
Gene Common Name(s) MGC14337; MSH-R; Mshra; SHEP2; Tob; e; extension recessive yellow; extension, recessive yellow; melanocyte hormone receptor alpha; tobacco darkening;
Molecular Note The mutation is a frameshift due to a deletion of a single nucleotide at position 549. This mutation is predicted to result in a protein that continues out of frame for 12 amino acids before terminating. [MGI Ref ID J:4636]

Related Strains

Strains carrying other alleles of Mc1r
003625   B6.C-H2-Ab1bm12/KhEg-Mc1re-J/J
001434   C3HeB/FeJ x STX/Le-Mc1rE-so Gli3Xt-J Tw/J
001533   C3HeB/FeJ-Mc1rE-so Gli3Xt-J/J
001000   RBD/DnJ
000726   RBF/DnJ
000807   RBJ/DnJ
View Strains carrying other alleles of Mc1r     (6 strains)

Research Applications

This mouse can be used to support research in many areas including:

Mc1re related

Dermatology Research
Color and White Spotting Defects (red hair color)
Skin and Hair Texture Defects

Endocrine Deficiency Research
Skin Defects

References

Additional References

Price and Supply Information

Strain Name: C57BL/6J-Mc1re/J
Stock Number: 000060

Price Details

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Supply Details

Standard SupplyRepository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information.
Supply Notes Cryorecovery - Standard.
The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two males and two females (two pairs) will be provided, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the delivery time to approximately 25 weeks. At least one member of each pair will be of known genotype and will carry the mutation if it is a mutant strain. Please note that pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Price represents a repository maintenance fee, which includes the cost of recovery of the strain from the cryopreservation resource and the periodic replacement of the frozen embryos used for recovery.

Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
One to two pairs will be recovered to establish a Dedicated Supply of mice. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services: Tel: 1-800-422-6423 or 1-207-288-5845; Email: jaxservices@jax.org.
Genomic DNA is available for this strain from the Mouse DNA Resource.

LicensingSee General Terms and Conditions below  

General Terms and Conditions

View JAX® Mice & Services Conditions of Use.

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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