Strain Name:

C57BL/6J-Mc1re/J

Stock Number:

000060

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Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Type Coisogenic; Mutant Strain; Spontaneous Mutation;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Specieslaboratory mouse

Development
The recessive yellow mutation (Mc1re) arose in 1963 in a C57BL/6Ha strain homozygous for Kitw at Roswell Park Memorial Institute. By 1970 Dr. Elizabeth Russell had imported Mc1re on the C57BL/6Ha background into The Jackson Laboratory and began backcrossing it onto C57BL/6J. In 1974 the strain, maintained by backcross-intercross, had reached generation N8, in 1976 it reached generation N12, in 1978 it reached generation N18, and in 1979 it was cryopreserved at generation N20.

Related Strains

Strains carrying other alleles of Mc1r
003625   B6.C-H2-Ab1bm12/KhEg-Mc1re-J/J
001434   C3HeB/FeJ x STX/Le-Mc1rE-so Gli3Xt-J Zeb1Tw/J
001533   C3HeB/FeJ-Mc1rE-so Gli3Xt-J/J
001000   RBD/DnJ
000726   RBF/DnJ
000807   RBJ/DnJ
000729   STOCK Rb(11.13)4Bnr/J
View Strains carrying other alleles of Mc1r     (7 strains)

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested.
Albinism, Oculocutaneous, Type II; OCA2   (MC1R)
Melanoma, Cutaneous Malignant, Susceptibility to, 5; CMM5   (MC1R)
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

Mc1re/Mc1re

        C57BL/6J-Mc1re/J
  • pigmentation phenotype
  • abnormal melanogenesis
    • in mutants, no measurable UV-induced melanization is observed; forskolin application to the skin induces significant skin darkening   (MGI Ref ID J:112959)
  • abnormal skin pigmentation
    • mice show no UV-induced detectable pigmentation changes, while wild-type ears show grossly and microscopically detectable hyperpigmentation   (MGI Ref ID J:112959)
  • cellular phenotype
  • abnormal keratinocyte apoptosis
    • forskolin pre-treatment produces UV protection similar to wild-type (black skinned) mice while untreated mutants are very UV-sensitive; untreated mice show formation of sunburn cells 24 hours after UV exposure   (MGI Ref ID J:112959)
  • increased cellular sensitivity to ionizing radiation   (MGI Ref ID J:112959)
  • integument phenotype
  • abnormal keratinocyte apoptosis
    • forskolin pre-treatment produces UV protection similar to wild-type (black skinned) mice while untreated mutants are very UV-sensitive; untreated mice show formation of sunburn cells 24 hours after UV exposure   (MGI Ref ID J:112959)
  • abnormal skin pigmentation
    • mice show no UV-induced detectable pigmentation changes, while wild-type ears show grossly and microscopically detectable hyperpigmentation   (MGI Ref ID J:112959)

Mc1re/Mc1re

        C57BL/6
  • behavior/neurological phenotype
  • abnormal touch/ nociception
    • mutant females and males display reduced pain sensitivity   (MGI Ref ID J:112815)
    • abnormal pain threshold
      • males display significantly higher latencies than females for the 49 degree water tail withdrawal test   (MGI Ref ID J:112815)
    • analgesia
      • 6-10 week old females and males display increased analgesic responsiveness to morphine-6-glucuronide when challenged with thermal nociception   (MGI Ref ID J:112815)
  • integument phenotype
  • abnormal touch/ nociception
    • mutant females and males display reduced pain sensitivity   (MGI Ref ID J:112815)
    • abnormal pain threshold
      • males display significantly higher latencies than females for the 49 degree water tail withdrawal test   (MGI Ref ID J:112815)
    • analgesia
      • 6-10 week old females and males display increased analgesic responsiveness to morphine-6-glucuronide when challenged with thermal nociception   (MGI Ref ID J:112815)

The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.

Mc1re/Mc1re

        C57BL/6Ha
  • pigmentation phenotype
  • abnormal hair follicle melanogenesis
    • neural tube-skin recombination grafting technique demonstrates that phaeomelanin (yellow coat color) is controlled by melanocyte genotype; not skin genotype   (MGI Ref ID J:5563)
  • yellow coat color
    • the clear yellow color accentuates the normal black eye color   (MGI Ref ID J:5110)
    • the entire length of the hair is yellow in adults; prior to weaning, homozygotes exhibit some dorsally concentrated umbrous sootiness but acquire an overall yellow coat with sucessive molts   (MGI Ref ID J:5110)
    • young mice have some eumelanin deposited in the hair tips, but adults have hairs predominantly pigmented with pheomelanin   (MGI Ref ID J:5620)
  • integument phenotype
  • abnormal hair follicle melanogenesis
    • neural tube-skin recombination grafting technique demonstrates that phaeomelanin (yellow coat color) is controlled by melanocyte genotype; not skin genotype   (MGI Ref ID J:5563)
  • yellow coat color
    • the clear yellow color accentuates the normal black eye color   (MGI Ref ID J:5110)
    • the entire length of the hair is yellow in adults; prior to weaning, homozygotes exhibit some dorsally concentrated umbrous sootiness but acquire an overall yellow coat with sucessive molts   (MGI Ref ID J:5110)
    • young mice have some eumelanin deposited in the hair tips, but adults have hairs predominantly pigmented with pheomelanin   (MGI Ref ID J:5620)

Mc1re/Mc1re

        involves: C57BL/6Ha
  • pigmentation phenotype
  • abnormal phaeomelanin content
    • the phaeomelanin to total melanin ratio is much higher (2.73) than in agouti controls (0.19)   (MGI Ref ID J:129904)
  • yellow coat color
    • mice have a yellow coat   (MGI Ref ID J:129904)
  • integument phenotype
  • abnormal phaeomelanin content
    • the phaeomelanin to total melanin ratio is much higher (2.73) than in agouti controls (0.19)   (MGI Ref ID J:129904)
  • yellow coat color
    • mice have a yellow coat   (MGI Ref ID J:129904)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Mc1re related

Dermatology Research
Color and White Spotting Defects
      red hair color
Skin and Hair Texture Defects

Endocrine Deficiency Research
Skin Defects

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Mc1re
Allele Name recessive yellow
Allele Type Spontaneous
Common Name(s) MC1-; Mc1r-; e;
Strain of OriginC57BL/6Ha
Gene Symbol and Name Mc1r, melanocortin 1 receptor
Chromosome 8
Gene Common Name(s) CMM5; MSH-R; Mshra; SHEP2; Tob; e; extension recessive yellow; extension, recessive yellow; melanocyte hormone receptor alpha; tobacco darkening;
Molecular Note The mutation is a frameshift due to a deletion of a single nucleotide at position 549. This mutation is predicted to result in a protein that continues out of frame for 12 amino acids before terminating. [MGI Ref ID J:4636]

Genotyping

Genotyping Information

Genotyping Protocols

Mc1re, End Point Analysis


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Additional References

Robbins LS; Nadeau JH; Johnson KR; Kelly MA; Roselli-Rehfuss L; Baack E; Mountjoy KG; Cone RD. 1993. Pigmentation phenotypes of variant extension locus alleles result from point mutations that alter MSH receptor function. Cell 72(6):827-34. [PubMed: 8458079]  [MGI Ref ID J:4636]

Mc1re related

April CS; Barsh GS. 2007. Distinct Pigmentary and Melanocortin 1 Receptor-Dependent Components of Cutaneous Defense against Ultraviolet Radiation. PLoS Genet 3(1):e9. [PubMed: 17222061]  [MGI Ref ID J:118235]

Bettenworth D; Buyse M; Bohm M; Mennigen R; Czorniak I; Kannengiesser K; Brzoska T; Luger TA; Kucharzik T; Domschke W; Maaser C; Lugering A. 2011. The tripeptide KdPT protects from intestinal inflammation and maintains intestinal barrier function. Am J Pathol 179(3):1230-42. [PubMed: 21741932]  [MGI Ref ID J:176323]

Cao J; Wan L; Hacker E; Dai X; Lenna S; Jimenez-Cervantes C; Wang Y; Leslie NR; Xu GX; Widlund HR; Ryu B; Alani RM; Dutton-Regester K; Goding CR; Hayward NK; Wei W; Cui R. 2013. MC1R is a potent regulator of PTEN after UV exposure in melanocytes. Mol Cell 51(4):409-22. [PubMed: 23973372]  [MGI Ref ID J:203944]

Chou WC; Takeo M; Rabbani P; Hu H; Lee W; Chung YR; Carucci J; Overbeek P; Ito M. 2013. Direct migration of follicular melanocyte stem cells to the epidermis after wounding or UVB irradiation is dependent on Mc1r signaling. Nat Med 19(7):924-9. [PubMed: 23749232]  [MGI Ref ID J:199836]

Cota CD; Liu RR; Sumberac TM; Jung S; Vencato D; Millet YH; Gunn TM. 2008. Genetic and phenotypic studies of the dark-like mutant mouse. Genesis 46(10):562-73. [PubMed: 18821597]  [MGI Ref ID J:143333]

D'Orazio JA; Nobuhisa T; Cui R; Arya M; Spry M; Wakamatsu K; Igras V; Kunisada T; Granter SR; Nishimura EK; Ito S; Fisher DE. 2006. Topical drug rescue strategy and skin protection based on the role of Mc1r in UV-induced tanning. Nature 443(7109):340-4. [PubMed: 16988713]  [MGI Ref ID J:112959]

Delaney A; Keighren M; Fleetwood-Walker SM; Jackson IJ. 2010. Involvement of the melanocortin-1 receptor in acute pain and pain of inflammatory but not neuropathic origin. PLoS One 5(9):e12498. [PubMed: 20856883]  [MGI Ref ID J:165119]

Geschwind II; Huseby RA; Nishioka R. 1972. The effect of melanocyte-stimulating hormone on coat color in the mouse. Recent Prog Horm Res 28:91-130. [PubMed: 4631622]  [MGI Ref ID J:5324]

Hauschka TS; Jacobs BB; Holdridge BA. 1968. Recessive yellow and its interaction with belted in the mouse. J Hered 59(6):339-41. [PubMed: 5713933]  [MGI Ref ID J:5110]

Healy E; Jordan SA; Budd PS; Suffolk R; Rees JL; Jackson IJ. 2001. Functional variation of MC1R alleles from red-haired individuals. Hum Mol Genet 10(21):2397-402. [PubMed: 11689486]  [MGI Ref ID J:72629]

Inomata K; Aoto T; Binh NT; Okamoto N; Tanimura S; Wakayama T; Iseki S; Hara E; Masunaga T; Shimizu H; Nishimura EK. 2009. Genotoxic stress abrogates renewal of melanocyte stem cells by triggering their differentiation. Cell 137(6):1088-99. [PubMed: 19524511]  [MGI Ref ID J:157347]

Jackson IJ; Budd PS; Keighren M; McKie L. 2007. Humanized MC1R transgenic mice reveal human specific receptor function. Hum Mol Genet 16(19):2341-8. [PubMed: 17652101]  [MGI Ref ID J:129904]

Lamoreux ML; Mayer TC. 1975. Site of gene action in the development of hair pigment in recessive yellow (e/e) mice. Dev Biol 46(1):160-6. [PubMed: 1098946]  [MGI Ref ID J:5563]

Lamoreux ML; Wakamatsu K; Ito S. 2001. Interaction of major coat color gene functions in mice as studied by chemical analysis of eumelanin and pheomelanin. Pigment Cell Res 14(1):23-31. [PubMed: 11277491]  [MGI Ref ID J:103803]

Lehman AL; Silvers WK; Puri N; Wakamatsu K; Ito S; Brilliant MH. 2000. The underwhite (uw) locus acts autonomously and reduces the production of melanin J Invest Dermatol 115(4):601-6. [PubMed: 10998130]  [MGI Ref ID J:64978]

Lu D; Willard D; Patel IR; Kadwell S; Overton L; Kost T; Luther M; Chen W; Woychik RP; Wilkison WO; Cone RD. 1994. Agouti protein is an antagonist of the melanocyte-stimulating-hormone receptor. Nature 371(6500):799-802. [PubMed: 7935841]  [MGI Ref ID J:21074]

Miller KA; Gunn TM; Carrasquillo MM; Lamoreux ML; Galbraith DB ; Barsh GS. 1997. Genetic studies of the mouse mutations mahogany and mahoganoid. Genetics 146(4):1407-15. [PubMed: 9258683]  [MGI Ref ID J:41964]

Mitra D; Luo X; Morgan A; Wang J; Hoang MP; Lo J; Guerrero CR; Lennerz JK; Mihm MC; Wargo JA; Robinson KC; Devi SP; Vanover JC; D'Orazio JA; McMahon M; Bosenberg MW; Haigis KM; Haber DA; Wang Y; Fisher DE. 2012. An ultraviolet-radiation-independent pathway to melanoma carcinogenesis in the red hair/fair skin background. Nature 491(7424):449-53. [PubMed: 23123854]  [MGI Ref ID J:189208]

Mogil JS; Ritchie J; Smith SB; Strasburg K; Kaplan L; Wallace MR; Romberg RR; Bijl H; Sarton EY; Fillingim RB; Dahan A. 2005. Melanocortin-1 receptor gene variants affect pain and mu-opioid analgesia in mice and humans. J Med Genet 42(7):583-7. [PubMed: 15994880]  [MGI Ref ID J:112815]

Mogil JS; Wilson SG; Chesler EJ; Rankin AL; Nemmani KV; Lariviere WR; Groce MK; Wallace MR; Kaplan L; Staud R; Ness TJ; Glover TL; Stankova M; Mayorov A; Hruby VJ; Grisel JE; Fillingim RB. 2003. The melanocortin-1 receptor gene mediates female-specific mechanisms of analgesia in mice and humans. Proc Natl Acad Sci U S A 100(8):4867-72. [PubMed: 12663858]  [MGI Ref ID J:83404]

Montero-Melendez T; Patel HB; Seed M; Nielsen S; Jonassen TE; Perretti M. 2011. The Melanocortin Agonist AP214 Exerts Anti-Inflammatory and Proresolving Properties. Am J Pathol 179(1):259-69. [PubMed: 21703408]  [MGI Ref ID J:174002]

Poole TW; Silvers WK. 1976. An experimental analysis of the recessive yellow coat color mutant in the mouse. Dev Biol 48(2):377-81. [PubMed: 767180]  [MGI Ref ID J:5620]

Robbins LS; Nadeau JH; Johnson KR; Kelly MA; Roselli-Rehfuss L; Baack E; Mountjoy KG; Cone RD. 1993. Pigmentation phenotypes of variant extension locus alleles result from point mutations that alter MSH receptor function. Cell 72(6):827-34. [PubMed: 8458079]  [MGI Ref ID J:4636]

Robinson S; Dixon S; August S; Diffey B; Wakamatsu K; Ito S; Friedmann PS; Healy E. 2010. Protection against UVR involves MC1R-mediated non-pigmentary and pigmentary mechanisms in vivo. J Invest Dermatol 130(7):1904-13. [PubMed: 20237490]  [MGI Ref ID J:161012]

Silvers WK. 1979. The Coat Colors of Mice; A Model for Mammalian Gene Action and Interaction. In: The Coat Colors of Mice. Springer-Verlag, New York.  [MGI Ref ID J:78801]

Wada A; Okumoto M; Tsudzuki M. 1999. Tawny: a novel light coat color mutation found in a wild population of Mus musculus molossinus, a new allele at the melanocortin 1 receptor (Mc1r) locus. Exp Anim 48(2):73-8. [PubMed: 10374067]  [MGI Ref ID J:55617]

Wakamatsu K; Hirobe T; Ito S. 2007. High levels of melanin-related metabolites in plasma from pink-eyed dilution mice. Pigment Cell Res 20(3):222-4. [PubMed: 17516930]  [MGI Ref ID J:148667]

von Lehmann E. 1973. Coat colour genetics of the tobacco-mouse (Mus poschiavinus Fatio) Mouse News Lett 48:23.  [MGI Ref ID J:22593]

von Lehmann E. 1974. Weitere Mitteilungen zu: coat colour genetics of the tobacco-mouse (Mus poschiavinus Fatio). Mouse News Lett 50:26-7.  [MGI Ref ID J:13641]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $2450.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Embryos

Price (US dollars $)
Frozen Embryo $1600.00

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryopreserved Embryos
    Available to most shipping destinations1
    This strain is also available as cryopreserved embryos2. Orders for cryopreserved embryos may be placed with our Customer Service Department. Experienced technicians at The Jackson Laboratory have recovered frozen embryos of this strain successfully. We will provide you enough embryos to perform two embryo transfers. The Jackson Laboratory does not guarantee successful recovery at your facility. For complete information on purchasing embryos, please visit our Cryopreserved Embryos web page.

    1 Shipments cannot be made to Australia due to Australian government import restrictions.
    2 Embryos for most strains are cryopreserved at the two cell stage while some strains are cryopreserved at the eight cell stage. If this information is important to you, please contact Customer Service.
  • Cryorecovery - Standard.
    Progeny testing is not required.
    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 11 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice
    Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $3185.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Embryos

Price (US dollars $)
Frozen Embryo $2080.00

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryopreserved Embryos
    Available to most shipping destinations1
    This strain is also available as cryopreserved embryos2. Orders for cryopreserved embryos may be placed with our Customer Service Department. Experienced technicians at The Jackson Laboratory have recovered frozen embryos of this strain successfully. We will provide you enough embryos to perform two embryo transfers. The Jackson Laboratory does not guarantee successful recovery at your facility. For complete information on purchasing embryos, please visit our Cryopreserved Embryos web page.

    1 Shipments cannot be made to Australia due to Australian government import restrictions.
    2 Embryos for most strains are cryopreserved at the two cell stage while some strains are cryopreserved at the eight cell stage. If this information is important to you, please contact Customer Service.
  • Cryorecovery - Standard.
    Progeny testing is not required.
    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 11 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice
    Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

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Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.


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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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