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- Description
- Phenotype
- Genes & alleles
- Genotyping
- Health & husbandry
- References
- Purchasing information
- Terms of Use
Description
The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.
Strain Information
Former Names STOCK a Tyrp1b Si/J (Changed: 16-JUN-05 ) STOCK a Tyrp1b si (Changed: 15-DEC-04 ) Type Mutant Stock; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Species laboratory mouse Generation pF4p Appearance
black with varying amounts of silver hairs
Related Genotype: a/a, Tyrp1b/Tyrp1b Sisi/Sisi or a/a Tyrp1b/+, Sisi/SisiDescription
Several proteins have been characterized as being critical for melanogenesis, including tyrosinase and its related proteins tyrosinase related protein 1 and 2 (TRP-1 and TRP-2). The silver locus protein (SI) is also crucial to the normal melanogenic pathway and it is believed that the interactions of these, and probably other, proteins are necessary for proper melanin pigment production within melanocytes. Nonagouti mice (a/a) homozygous for the recessive si mutation display a range of coat color variations, including all black and all white. Also, single hairs can be both black and white as the tips contain no pigment while the base retains pigmentation. Black and white banding patterns in individual hairs is also observed. It is noted that similar si/si hair color variation is also seen on the agouti background. Young a/a mice typically have black hairs, with some silver/grey hair present on the head, behind the ears and around the posterior. The hair generally becomes progressively lighter with age, with the males displaying more silvering than the females. The silver mutation causes a graying of hair because the follicular melanocytes become dysfunctional and eventually die. Variations in the silvering of the coat color reflect an overall reduction in the number or total lack of melanocytic pigment granules. The loss of these melanocytes, in fact, co-localizes with hypopigmented hair follicles. Also, reduced viability of si/si melanocytes is observed in vitro where these cultured cells exhibit very slow growth rates and have a reduced life span compared to similarly prepared wild type melanocytes.Functionally, two general activities have been linked to GP87. First, this protein has been reported to be a stabilizing structural matrix glycoprotein in cultured B16 murine melanoma cells as the carboxy-terminus contains an epitope that is recognized by the anti-melanosomal matrix protein antibody alpha-MX. The protein is exclusively restricted to the melanosomal compartment itself as shown by Western blotting of sub-cellular fractions, but is not detected in coated vesicles that shuttle tyrosinase-related proteins to melanosomes. Therefore, the trafficking of the silver protein is distinct. The predicted protein product of GP87 contains a single potential transmembrane domain but based on detergent solubility studies, the protein is likely to be loosely associated with the melanosomal matrix, or contained near the inner aspects of the organelle membrane, or even free in the space between the matrix and membrane. This is in contrast to the subcellular localization of TRP-1 and TRP-2, which are known integral membrane proteins. GP87 is rapidly synthesized and delivered to the melanosomes. Soon after, the protein is processed to lose its C-terminus, as shown through specific reactivity by using a peptide that recognizes this epitope (alpha PEP13). It is not clear what function this post-translational step plays in the normal melanosome but by acting as a structural component, the silver protein could restrict melanogenesis to the appropriate intracellular compartment and 1) protect the cells from toxic melanogenic metabolites such as 5,6-dihydroxyindole and/or 2) stabilize melanin metabolites such as dihydroxyindoles and indolequinones. The silver protein has also been proposed to have an enzymatic role in catalyzing melanin formation through the polymerization of 5,6-dihydroxyindole-2-carboxylic acid (DHICA). Melanin synthesis via the enzymatic conversion of DHICA was found to be mediated by the silver protein through an immunopurification assay conducted on extracts from cultured Cloudman S91 mouse melanoma cells.
Based on primary sequence analysis, the protein product of the si allele is predicted to be mistargeted within melanocytes. Direct evidence for this comes from melan-Si cells (Tyrp1b/+ Sisi/Sisi). These si/si cells express the mutant protein abnormally outside of the melanosome/pre-melanosome in the soluble fraction where the protein appears degraded or in aggregates. The mutant silver protein, therefore, is misrouted within si/si melanosomes. Interestingly, tyrosinase also is not normally localized within the melan-Si cells. Disrupted protein distribution in the silver mutant melanosomes likely results in a lack of the formation of functional melanogenic complexes containing GP87, tyrosinase and TRPs. While it is not clear what leads to si/si melanocyte death, it could be due to cytotoxic events induced by the mutation that causes the release of toxic melanin precursors. The chemical properties of melanins found in Si hair pigment granules were quantified by high-performance liquid chromatography and spectrophotometric assays measuring levels of pyrrole-2,3,5-tricarboxylic acid (PTCA), aminohydroxyphenylalanine (AHP), spectrophotometric eumelanin (SE), spectrophotometric pheomelanin (SP) and alkali-soluble melanins. The chemical properties of silver hair-derived melanins are similar to brown and light hair melanins but as expected, the total melanin content is much lower compared to black hair melanins (reduced by one-fifth to one-tenth). Chemical characterization of the pigment forms found in silver melanins revealed a partial suppression of eumelanogenesis similar to that seen in the brown hair locus mutants (encoding tyrosinase-related protein 1).
Follicular melanocytes of silver mice are more susceptible to damage resulting from X-irradiation. Since human GP100 is an antigenic marker for a variety of human melanomas that can be recognized by CD8+ T lymphocytes, the silver mutant might serve as a model to experimentally test for potential immunotherapies. (Dunn and Thigpen, 1930; Spanakis et al., 1992; Ozeki et al., 1995; Lamoreux et al., 2001; Kwon et al., 1995; Martinez-Esparza et al., 1999; Zhou et al., 1994; Kobayashi et al., 1994; Solano et al., 2000; Chakraborty et al., 1996; Berson et al., 2001; Martinez-Esparza et al., 2000b; Cormier et al., 1998).
Development
This "silver grey" stock was acquired by Dunn and Thigpen (Dunn and Thigpen 1930) in 1927 from a single pair of mice from the house mouse colony, where the mutation arose, maintained by English fancier William Turton. Silver (Dunn-MacDowell-Gowen) was subsequently maintained in LGW inbred mice at Iowa State University and was bred into the linkage stock carrying Pcdh15av/Pcdh15av, Sisi/Sisi, Tyrp1b/+, ae/ae (RH Schaible, 1957). Pcdh15av is a mutation that arose on the K strain in 1955 and linkage with the silver locus was demonstrated (RH Schaible, 1961); extreme non-agouti, ae, appeared in mice descending from x-ray mutagenized male breeders of the S strain (Hollander and Gowen, 1956). In 1963, this "av" linkage stock was imported from RH Schaible to the Jackson Laboratory where mice were sibling mated for 14 generations. A single outcross to C57BL/10Gn occurred in 1968 and mice were sibling mating thereafter; Pcdh15av has not been detected in this stock since the outcross. In 1979 at about F50, males from this strain (a/a, Tyrp1b/Tyrp1b, Sisi/Sisi) were outcrossed to female B6C3Fe-a/a F1 mice for frozen embryo storage. In 1987, B6C3Fe-a/a X STOCK a Tyrp1b Sisi embryos were thawed and a live stock reconstituted. These mice were sibling mated [F1p] F3 through F5 to generate additional embryo stocks in 1988. Either of these sets of frozen stocks may be used to reconstitute this strain. Embryos are homozygous for both the silver mutation and a, and segregate for the Tyrp1b allele.
Related Strains
Strains carrying Tyrp1b allele
000004 ABP/LeJ 000571 B6.Cg-Whrnwi Tyrp1b/+ +/J 000027 B6.D-Tyrp1b Dock7m/J 000670 DBA/1J 000265 MY/HuLeJ 001045 SI/Col Tyrp1b Dnahc11iv/J 002238 STOCK a Tyrp1b shmy/J 001432 STOCK a/a Tyrp1b sks/Tyrp1b +/J 000594 STOCK T(2;8)26H a/T(2;8)26H a Tyrp1+/Tyrp1b/J 001101 STOCK T(3;4)5Rk Tyrp1b/J 000274 TSJ/LeJ View Strains carrying Tyrp1b (11 strains)
000957 AKXD28/TyJ 000093 B6.B10(D1)-Tyrp1b-c/J 008684 B6.Cg-Rag1tm1Mom Tyrp1B-w Tg(Tcra,Tcrb)9Rest/J 000068 C57BL/6J-Tyrp1b-J/J 000671 DBA/2J 006252 LT/SvEiJ 002142 STOCK 11R30m/J 000594 STOCK T(2;8)26H a/T(2;8)26H a Tyrp1+/Tyrp1b/J
Phenotype
Phenotype Information
assigned by genotype
Sisi/Sisi
STOCK a Tyrp1b Sisi/J
- pigmentation phenotype
- *normal* pigmentation phenotype (MGI Ref ID J:141035)
- mice exhibit wild-type iris pigmentation
The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.
Sisi/Sisi
Background Not Specified
- pigmentation phenotype
- irregular coat pigmentation (MGI Ref ID J:78801)
- random inviability of melanoblasts in hair follicles results in mice that are variegated for white, partially pigmented (gray) hairs, and fully pigmented hairs
- other pigment loci influence appearance: nonagouti mice display silvering more on the belly than on the back and become more silvery with age, with nonagouti and brown, mice display fewer white and partially white hairs, and with agouti the yellow band at the tip of hairs is not affected but the base of each hair is lightened creating a whiteish "underfur" and silvering decreases with age
- the merle pigment pattern is difficult to classify in different crosses
- reduced hair shaft melanin granule number (MGI Ref ID J:13051)
- the basis for variable silvering of the coat
- skin/coat/nails phenotype
- irregular coat pigmentation (MGI Ref ID J:78801)
- random inviability of melanoblasts in hair follicles results in mice that are variegated for white, partially pigmented (gray) hairs, and fully pigmented hairs
- other pigment loci influence appearance: nonagouti mice display silvering more on the belly than on the back and become more silvery with age, with nonagouti and brown, mice display fewer white and partially white hairs, and with agouti the yellow band at the tip of hairs is not affected but the base of each hair is lightened creating a whiteish "underfur" and silvering decreases with age
- the merle pigment pattern is difficult to classify in different crosses
- reduced hair shaft melanin granule number (MGI Ref ID J:13051)
- the basis for variable silvering of the coat
- homeostasis/metabolism phenotype
- *normal* homeostasis/metabolism phenotype (MGI Ref ID J:29151)
- no aberrant bleeding time after tail vein nick
- hematopoietic system phenotype
- *normal* hematopoietic system phenotype (MGI Ref ID J:29151)
- NORMAL: bleeding time is normal
This mouse can be used to support research in many areas including:Sisi related
Tyrp1b relatedDermatology Research
Color and White Spotting Defects
Mouse/Human Gene Homologs
oculocutaneous albinism type III
Genes & Alleles
Gene & Allele Information
| Allele Symbol | Sisi | ||
|---|---|---|---|
| Allele Name | silver | ||
| Allele Type | Spontaneous | ||
| Common Name(s) | Pmel 17; gp100; gp87; | ||
| Gene Symbol and Name | Si, silver | ||
| Chromosome | 10 | ||
| Gene Common Name(s) | D10H12S53E; D12S53E; D12S53Eh; DNA segment, Chr 10, human D12S53E; ME20; PMEL; PMEL17; SIL; gp100; gp87; | ||
| General Note | This mutation arose in an unspecified English fancy stock. | ||
| Molecular Note | Sequencing of partial gp87 cDNA from homozygous mutant melanocytes showed this mutation comprises a G to A substitution at base 1808, resulting in a premature stop codon and truncation of the protein in the C-terminal cystolic domain. [MGI Ref ID J:22779] [MGI Ref ID J:58687] | ||
| Allele Symbol | Tyrp1b | ||
| Allele Name | brown | ||
| Allele Type | Spontaneous | ||
| Common Name(s) | b; | ||
| Strain of Origin | old mutant of the mouse fancy | ||
| Gene Symbol and Name | Tyrp1, tyrosinase-related protein 1 | ||
| Chromosome | 4 | ||
| Gene Common Name(s) | B; CAS2; CATB; GP75; TRP; TRP-1; TRP1; TYRP; Tyrp; b; b-PROTEIN; brown; iris stromal atrophy; isa; tyrosinase-related protein; | ||
| General Note | The eumelanin of the hair and eyes is brown rather than black. The pigment granules also appear brown rather than black and are spheroid rather than ovoid in shape (J:12970). The fine structure of the developing pigment granules is fibrillar, like that of wild-type mice, but the appearance of the mature granule may be more coarsely granular (J:5346, J:5001, J:5068). The granules incorporate twice as much 14C-tyrosine as normal (J:12173). | ||
| Molecular Note | A G-to-A transition point mutation at position 329 was shown by revertant analysis to be responsible for the mutant phenotype seen in the brown mutant. This mutation is predicted to change a cysteine residue to a tyrosine in the encoded protein. Three other point mutations in the brown sequence were identified, but do not contribute to the mutant phenotype. [MGI Ref ID J:44435] | ||
| Allele Symbol | a | ||
| Allele Name | nonagouti | ||
| Allele Type | Spontaneous | ||
Genotyping
Genotyping Information
This strain will not have a genotyping protocol or one is not currently available.
Helpful Links
Genotyping resources and troubleshooting
References
References
Additional References
Kobayashi T; Urabe K; Orlow SJ; Higashi K; Imokawa G; Kwon BS; Potterf B; Hearing VJ. 1994. The Pmel 17/silver locus protein. Characterization and investigation of its melanogenic function. J Biol Chem 269(46):29198-205. [PubMed: 7961886] [MGI Ref ID J:21502]
Kwon BS; Halaban R; Ponnazhagan S; Kim K; Chintamaneni C; Bennett D; Pickard RT. 1995. Mouse silver mutation is caused by a single base insertion in the putative cytoplasmic domain of Pmel 17. Nucleic Acids Res 23(1):154-8. [PubMed: 7870580] [MGI Ref ID J:22779]
Martinez-Esparza M; Jimenez-Cervantes C; Bennett DC; Lozano JA; Solano F; Garcia-Borron JC. 1999. The mouse silver locus encodes a single transcript truncated by the silver mutation. Mamm Genome 10(12):1168-71. [PubMed: 10594241] [MGI Ref ID J:58687]
Ozeki H; Ito S; Wakamatsu K; Hirobe T. 1995. Chemical characterization of hair melanins in various coat-color mutants of mice. J Invest Dermatol 105(3):361-6. [PubMed: 7665913] [MGI Ref ID J:28766]
Schreurs MW; de Boer AJ; Schmidt A; Figdor CG; Adema GJ. 1997. Cloning, expression and tissue distribution of the murine homologue of the melanocyte lineage-specific antigen gp100 Melanoma Res 7(6):463-70. [PubMed: 9464618] [MGI Ref ID J:45267]
Zhai Y; Yang JC; Spiess P; Nishimura MI; Overwijk WW; Roberts B; Restifo NP; Rosenberg SA. 1997. Cloning and characterization of the genes encoding the murine homologues of the human melanoma antigens MART1 and gp100. J Immunother 20(1):15-25. [PubMed: 9101410] [MGI Ref ID J:38811]
Zhou BK; Kobayashi T; Donatien PD; Bennett DC; Hearing VJ; Orlow SJ. 1994. Identification of a melanosomal matrix protein encoded by the murine si (silver) locus using organelle scanning. Proc Natl Acad Sci U S A 91(15):7076-80. [PubMed: 8041749] [MGI Ref ID J:19440]
Sisi relatedTyrp1b relatedAnderson MG; Hawes NL; Trantow CM; Chang B; John SW. 2008. Iris phenotypes and pigment dispersion caused by genes influencing pigmentation. Pigment Cell Melanoma Res 21(5):565-78. [PubMed: 18715234] [MGI Ref ID J:141035]
Dunn LC; Thigpen LW. 1930. The silver mouse, a recessive color variation. J Hered 21:495-498. [MGI Ref ID J:13051]
Hogan ME; King LE Jr; Sundberg JP. 1995. Defects of pelage hairs in 20 mouse mutations. J Invest Dermatol 104(5 Suppl):31S-32S. [PubMed: 7738386] [MGI Ref ID J:25255]
Kwon BS; Halaban R; Ponnazhagan S; Kim K; Chintamaneni C; Bennett D; Pickard RT. 1995. Mouse silver mutation is caused by a single base insertion in the putative cytoplasmic domain of Pmel 17. Nucleic Acids Res 23(1):154-8. [PubMed: 7870580] [MGI Ref ID J:22779]
Lamoreux ML; Wakamatsu K; Ito S. 2001. Interaction of major coat color gene functions in mice as studied by chemical analysis of eumelanin and pheomelanin. Pigment Cell Res 14(1):23-31. [PubMed: 11277491] [MGI Ref ID J:103803]
Martinez-Esparza M; Jimenez-Cervantes C; Bennett DC; Lozano JA; Solano F; Garcia-Borron JC. 1999. The mouse silver locus encodes a single transcript truncated by the silver mutation. Mamm Genome 10(12):1168-71. [PubMed: 10594241] [MGI Ref ID J:58687]
Silvers WK. 1979. The Coat Colors of Mice; A Model for Mammalian Gene Action and Interaction. In: The Coat Colors of Mice. Springer-Verlag, New York. [MGI Ref ID J:78801]
Sundberg JP (ed.). 1994. . In: Handbook of Mouse Mutations with Skin and Hair Abnormalities: Animal Models and Biomedical Tools. CRC Press, Boca Raton. [MGI Ref ID J:30359]
Swank RT; Reddington M; Howlett O; Novak EK. 1991. Platelet storage pool deficiency associated with inherited abnormalities of the inner ear in the mouse pigment mutants muted and mocha. Blood 78(8):2036-44. [PubMed: 1912584] [MGI Ref ID J:29151]
Theos AC; Berson JF; Theos SC; Herman KE; Harper DC; Tenza D; Sviderskaya EV; Lamoreux ML; Bennett DC; Raposo G; Marks MS. 2006. Dual loss of ER export and endocytic signals with altered melanosome morphology in the silver mutation of Pmel17. Mol Biol Cell 17(8):3598-612. [PubMed: 16760433] [MGI Ref ID J:113433]
Anderson MG; Libby RT; Mao M; Cosma IM; Wilson LA; Smith RS; John SW. 2006. Genetic context determines susceptibility to intraocular pressure elevation in a mouse pigmentary glaucoma. BMC Biol 4:20. [PubMed: 16827931] [MGI Ref ID J:128215]
Anderson MG; Nair KS; Amonoo LA; Mehalow A; Trantow CM; Masli S; John SW. 2008. GpnmbR150X allele must be present in bone marrow derived cells to mediate DBA/2J glaucoma. BMC Genet 9:30. [PubMed: 18402690] [MGI Ref ID J:134670]
Brooks BP; Larson DM; Chan CC; Kjellstrom S; Smith RS; Crawford MA; Lamoreux L; Huizing M; Hess R; Jiao X; Hejtmancik JF; Maminishkis A; John SW; Bush R; Pavan WJ. 2007. Analysis of ocular hypopigmentation in Rab38cht/cht mice. Invest Ophthalmol Vis Sci 48(9):3905-13. [PubMed: 17724166] [MGI Ref ID J:124886]
Center EM; Hunter RL; Dodge AH. 1967. Effects of the luxoid gene (lu) on liver esterase isozymes of the mouse. Genetics 55(2):349-58. [PubMed: 6067640] [MGI Ref ID J:109970]
Coleman DL. 1962. Effect of genic substitution on the incorporation of tyrosine into the melanin of mouse skin. Arch Biochem Biophys 96:562-8. [PubMed: 13880466] [MGI Ref ID J:12173]
Gruneberg H. 1952. . In: The Genetics of the Mouse. Martinus Nijhoff, The Hague. [MGI Ref ID J:30758]
Hearing VJ; Phillips P; Lutzner MA. 1973. The fine structure of melanogenesis in coat color mutants of the mouse. J Ultrastruct Res 43(1):88-106. [PubMed: 4634048] [MGI Ref ID J:5346]
Howell GR; Libby RT; Jakobs TC; Smith RS; Phalan FC; Barter JW; Barbay JM; Marchant JK; Mahesh N; Porciatti V; Whitmore AV; Masland RH; John SW. 2007. Axons of retinal ganglion cells are insulted in the optic nerve early in DBA/2J glaucoma. J Cell Biol 179(7):1523-37. [PubMed: 18158332] [MGI Ref ID J:131073]
Hunsicker PR. 1969. White-based brown, B<W> Mouse News Lett 40:41. [MGI Ref ID J:13492]
Kobayashi T; Imokawa G; Bennett DC; Hearing VJ. 1998. Tyrosinase stabilization by Tyrp1 (the brown locus protein). J Biol Chem 273(48):31801-5. [PubMed: 9822646] [MGI Ref ID J:51301]
Lamoreux ML; Wakamatsu K; Ito S. 2001. Interaction of major coat color gene functions in mice as studied by chemical analysis of eumelanin and pheomelanin. Pigment Cell Res 14(1):23-31. [PubMed: 11277491] [MGI Ref ID J:103803]
Little CC. 1916. The occurrence of three recognized coat mutations in mice Am Naturalist 1:335-349. [MGI Ref ID J:150254]
Markert CL; Silvers WK. 1956. The Effects of Genotype and Cell Environment on Melanoblast Differentiation in the House Mouse. Genetics 41(3):429-50. [PubMed: 17247639] [MGI Ref ID J:12970]
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Mouse Genome Informatics (MGI). 2005. Information obtained from the Oak Ridge National Laboratory Mutant Mouse Database (ORNL), Oak Ridge, TN (http://bio.lsd.ornl.gov/mouse/) :. [MGI Ref ID J:100221]
Moyer FH. 1966. Genetic variations in the fine structure and ontogeny of mouse melanin granules. Am Zool 6(1):43-66. [PubMed: 5902512] [MGI Ref ID J:5001]
Murray WS. 1934. The breeding behavior of the dilute brown stock of mice (Little dba) Am J Cancer 20:573-593. [MGI Ref ID J:2464]
RIKEN BioResource Center/RIKEN Genomic Sciences Center. 2008. A Large Scale Mutagenesis Program in RIKEN GSC PhenoSITE, World Wide Web (URL: http://www.brc.riken.jp/lab/gsc/mouse/) :. [MGI Ref ID J:133634]
RUSSELL ES. 1949. A quantitative histological study of the pigment found in the coat-color mutants of the house mouse; interdependence among the variable granule attributes. Genetics 34(2):133-45. [PubMed: 18117146] [MGI Ref ID J:148461]
Raymond S; Jackson IJ. 1994. Molecular characterization of the mouse B<w> mutation causing premature melanocyte death - melanocytes and early development Genet Res 63(2):155 (Abstr). [MGI Ref ID J:18590]
Rittenhouse E. 1968. Genetic effect on fine structure and development of pigment granules in mouse hair bulb melanocytes. I. The b and d loci. Dev Biol 17(4):351-65. [PubMed: 5650006] [MGI Ref ID J:5068]
Russell ES. 1948. A Quantitative Histological Study of the Pigment Found in the Coat Color Mutants of the House Mouse. II. Estimates of the Total Volume of Pigment. Genetics 33(3):228-36. [PubMed: 17247280] [MGI Ref ID J:148462]
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Silvers WK. 1979. The Coat Colors of Mice; A Model for Mammalian Gene Action and Interaction. In: The Coat Colors of Mice. Springer-Verlag, New York. [MGI Ref ID J:78801]
Smyth IM; Wilming L; Lee AW; Taylor MS; Gautier P; Barlow K; Wallis J; Martin S; Glithero R; Phillimore B; Pelan S; Andrew R; Holt K; Taylor R; McLaren S; Burton J; Bailey J; Sims S; Squares J; Plumb B; Joy A; Gibson R; Gilbert J; Hart E; Laird G; Loveland J; Mudge J; Steward C; Swarbreck D; Harrow J; North P; Leaves N; Greystrong J; Coppola M; Manjunath S; Campbell M; Smith M; Strachan G; Tofts C; Boal E; Cobley V; Hunter G; Kimberley C; Thomas D; Cave-Berry L; Weston P; Botcherby MR; White S; Edgar R; C. 2006. Genomic anatomy of the Tyrp1 (brown) deletion complex. Proc Natl Acad Sci U S A 103(10):3704-9. [PubMed: 16505357] [MGI Ref ID J:107243]
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Health & husbandry
Health & Colony Maintenance Information
Currently there no information available for this strain. This may be due to the supply level of this strain.
Purchasing information
Pricing, Supply Level & Notes, Controls, General Terms & Conditions
Pricing
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Animals Provided
Price (US dollars $) Cryorecovery Fee $1900.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Additional Supply Details
| Pricing for International shipping destinations |
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Animals Provided
Price (US dollars $) Cryorecovery Fee $2470.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Additional Supply Details
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Supply Details
| Standard Supply | Cryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information. |
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MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.
The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.
Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.