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- Description
- Disease & phenotype
- Genes & alleles
- Genotyping
- Health & care
- References
- Pricing & purchasing
- Terms of use
Description
The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.
Strain Information
Type Mutant Stock; Spontaneous Mutation; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Species laboratory mouse Generation N4F1p
Generation DefinitionsAppearance
Pax1un and we: black and tan, wavy tail, wavy fur
Related Genotype: Pax1un we at/Pax1un we ?
Pax1un and we: black and tan, normal tail and fur
Related Genotype: + + a/we Pax1un at or + + ?/? ? at
Pax1un and we: black, normal tail and fur
Related Genotype: + + a/? ? a
at: black and tan, wavy tail, wavy fur
Related Genotype: at/a Pax1un/a Pax1un we/we
at: black and tan
Related Genotype: at/aDescription
The affected mutant (we Pax1un at/we Pax1un a?) has a wavy coat, wavy tail, and is black and tan.Development
A mixed stock containing at, Pax1un, we, and other mutations was imported into The Jackson Laboratory from Edinburgh in 1952. The at Pax1un we line was maintained by sibling matings until F7 then outcrossed to C57BL/6J and again sibling mated to F19 before being outcrossed again to C57BL/6J and then sibling mated to F44. It was lastly outcrossed to the hybrid B6C3Fe-a/a and then maintained by cross-intercross to this F1 until NE15. In 1979 embryos were generated for cryopreservation by breeding heterozygous females (at Pax1un we/a + +) with homozygous males (at Pax1un we/at Pax1un we).
Control Information
| Control | ||
|---|---|---|
| Untyped from the colony | ||
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying Pax1un allele
000419 B10.UW-H3b we Pax1un at/SnJ View Strains carrying Pax1un (1 strain)
000477 B10.PA-Bloc1s6pa H3e at/SnJ 000419 B10.UW-H3b we Pax1un at/SnJ 000262 LS/LeJ
000419 B10.UW-H3b we Pax1un at/SnJ 000288 B6CBACa Aw-J/A-we a Mafbkr/J
003656 AKR/J-we4J/J 000475 B10.129-weBkr/CyJ
Phenotype
Phenotype Information
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested. Skin/Hair/Eye Pigmentation, Variation In, 9; SHEP9 (ASIP)
assigned by genotype
The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.
Pax1un/Pax1un
B6.Cg-Pax1un
- skeleton phenotype
- abnormal cervical vertebrae morphology
- the ossification center of C7 is missing unlike in wild-type mice (MGI Ref ID J:49339)
- abnormal lumbar vertebrae morphology
- abnormal rib attachment
- the proximal ends of the thirteenth rib pair are ossified unlike in wild-type mice (MGI Ref ID J:49339)
we/we
Background Not Specified
- integument phenotype
- curly vibrissae
- curly whiskers are evident shortly after birth (MGI Ref ID J:208)
- thin hair shaft
- smaller average diameter hair shaft than normal (MGI Ref ID J:208)
- waved hair
- the coat comes in very wavy, the wave most apparent between 10 and 21 days of age, then the wave decreases with age (MGI Ref ID J:208)
This mouse can be used to support research in many areas including:Pax1un related
at relatedDevelopmental Biology Research
Skeletal Defects
we relatedDermatology Research
Color and White Spotting Defects
Skin and Hair Texture Defects
Genes & Alleles
Gene & Allele Information provided by MGI
| Allele Symbol | Pax1un | ||
|---|---|---|---|
| Allele Name | undulated | ||
| Allele Type | Spontaneous | ||
| Common Name(s) | un; | ||
| Strain of Origin | fancier's mice | ||
| Gene Symbol and Name | Pax1, paired box gene 1 | ||
| Chromosome | 2 | ||
| Gene Common Name(s) | HUP48; Pax-1; hbs; hunchback; un; undulated; wavy tail; wt; | ||
| Molecular Note | A point mutation results in a substitution of glycine for serine at position 15 of the paired box motifand markedly decreases the DNA-binding ability of the Pax1 protein and changes its DNA specificity. [MGI Ref ID J:9424] | ||
| Allele Symbol | at | ||
| Allele Name | black and tan | ||
| Allele Type | Spontaneous | ||
| Strain of Origin | English fancy stock | ||
| Gene Symbol and Name | a, nonagouti | ||
| Chromosome | 2 | ||
| Gene Common Name(s) | AGSW; AGTI; AGTIL; ASP; As; SHEP9; agouti; agouti signal protein; agouti suppressor; | ||
| General Note | This allele is recessive to A and Aw on the dorsum and dominant to all agouti alleles on the ventrum except for Aw from which it is indistinguishable (J:78801) . | ||
| Molecular Note | This allele comprises a 6 kb insertion containing a retrovirus-like transposable element VL30 and a single 526 bp repeat into the first intron of the agouti gene at the same position as for alleles a and Aw. [MGI Ref ID J:16984] | ||
| Allele Symbol | we | ||
| Allele Name | wellhaarig | ||
| Allele Type | Spontaneous | ||
| Strain of Origin | Agnes Bluhm's stocks | ||
| Gene Symbol and Name | we, wellhaarig | ||
| Chromosome | 2 | ||
References
References provided by MGI
Additional References
Pax1un relatedat relatedAubin J; Lemieux M; Moreau J; Lapointe J; Jeannotte L. 2002. Cooperation of Hoxa5 and Pax1 Genes during Formation of the Pectoral Girdle. Dev Biol 244(1):96-113. [PubMed: 11900462] [MGI Ref ID J:75823]
Balling R; Deutsch U; Gruss P. 1988. undulated, a mutation affecting the development of the mouse skeleton, has a point mutation in the paired box of Pax 1. Cell 55(3):531-5. [PubMed: 3180219] [MGI Ref ID J:9424]
Bialek P; Chan CT; Yee SP. 2000. Characterization of a novel insertional mouse mutation, kkt: A closely linked modifier of Pax1. Dev Biol 218(2):354-66. [PubMed: 10656775] [MGI Ref ID J:60410]
Chalepakis G; Fritsch R; Fickenscher H; Deutsch U; Goulding M; Gruss P. 1991. The molecular basis of the undulated/Pax-1 mutation. Cell 66(5):873-84. [PubMed: 1889089] [MGI Ref ID J:31264]
Dietrich S; Gruss P. 1995. undulated phenotypes suggest a role of Pax-1 for the development of vertebral and extravertebral structures. Dev Biol 167(2):529-48. [PubMed: 7875377] [MGI Ref ID J:23331]
Gruneberg H. 1950. Genetical studies on the skeleton of the mouse. II. Undulated and its "modifiers". J Genet 50:142-173. [MGI Ref ID J:13037]
Gruneberg H. 1954. Genetical studies on the skeleton of the mouse. XII. The development of undulated. J Genet 52(2):441-455. [MGI Ref ID J:13043]
Helwig U; Imai K; Schmahl W; Thomas BE; Varnum DS; Nadeau JH; Balling R. 1995. Interaction between undulated and Patch leads to an extreme form of spina bifida in double-mutant mice. Nat Genet 11(1):60-3. [PubMed: 7550316] [MGI Ref ID J:28396]
Johnson DR. 1976. The interfrontal bone and mutant genes in the mouse. J Anat 121(3):507-13. [PubMed: 1018005] [MGI Ref ID J:5776]
Joosten PH; van Zoelen EJ; Murre C. 2005. Pax1/E2a Double-Mutant Mice Develop Non-Lethal Neural Tube Defects that Resemble Human Malformations. Transgenic Res 14(6):983-7. [PubMed: 16315099] [MGI Ref ID J:103567]
Nadeau JH. 2001. Modifier genes in mice and humans. Nat Rev Genet 2(3):165-74. [PubMed: 11256068] [MGI Ref ID J:88013]
Quondamatteo F; Zieger J; Gotz W; Miosge N; Herken R. 2000. Extensive glycosylation changes revealed by lectin histochemistry in morphologically normal prenatal tissues of the mouse mutant undulated (un/un). Anat Rec 258(3):243-51. [PubMed: 10705344] [MGI Ref ID J:61387]
Timmons PM; Wallin J; Rigby PW; Balling R. 1994. Expression and function of Pax 1 during development of the pectoral girdle. Development 120(10):2773-85. [PubMed: 7607069] [MGI Ref ID J:20965]
Wilm B; Dahl E; Peters H; Balling R; Imai K. 1998. Targeted disruption of Pax1 defines its null phenotype and proves haploinsufficiency. Proc Natl Acad Sci U S A 95(15):8692-7. [PubMed: 9671740] [MGI Ref ID J:49339]
Wright ME. 1947. Undulated: a new genetic factor in Mus musculus affecting the spine and tail Heredity 1:137-41. [MGI Ref ID J:314]
we relatedBultman SJ; Klebig ML; Michaud EJ; Sweet HO; Davisson MT; Woychik RP. 1994. Molecular analysis of reverse mutations from nonagouti (a) to black-and-tan (a(t)) and white-bellied agouti (Aw) reveals alternative forms of agouti transcripts. Genes Dev 8(4):481-90. [PubMed: 8125260] [MGI Ref ID J:16984]
Candille SI; Raamsdonk CD; Chen C; Kuijper S; Chen-Tsai Y; Russ A; Meijlink F; Barsh GS. 2004. Dorsoventral patterning of the mouse coat by tbx15. PLoS Biol 2(1):E3. [PubMed: 14737183] [MGI Ref ID J:87455]
Dickie MM. 1969. Mutations at the agouti locus in the mouse. J Hered 60(1):20-5. [PubMed: 5798139] [MGI Ref ID J:30922]
Dunn LC. 1928. A Fifth Allelomorph in the Agouti Series of the House Mouse. Proc Natl Acad Sci U S A 14(10):816-9. [PubMed: 16587414] [MGI Ref ID J:15011]
Dunn LC. 1936. Studies on multiple allelomorphic series in the house mouse. I. Description of agouti and albino series of allelomorphs J Genet 33:443-53. [MGI Ref ID J:22600]
Galbraith DB; Wolff GL; Brewer NL. 1980. Hair pigment patterns in different integumental environments of the mouse. Influence of the agouti suppressor (A<s>) mutation on expression of agouti locus alleles. J Hered 71:229-234. [MGI Ref ID J:12033]
Hollander WF. 1973. a<t>/a Mouse News Lett 48:33. [MGI Ref ID J:27528]
Leamy LJ; Hrubant HE. 1971. Effects of alleles at the agouti locus on odontometric traits in the C57BL-6 strain of house mice. Genetics 67(1):87-96. [PubMed: 5556294] [MGI Ref ID J:16571]
Miller MW; Duhl DM; Vrieling H; Cordes SP; Ollmann MM; Winkes BM; Barsh GS. 1993. Cloning of the mouse agouti gene predicts a secreted protein ubiquitously expressed in mice carrying the lethal yellow mutation. Genes Dev 7(3):454-67. [PubMed: 8449404] [MGI Ref ID J:4186]
MouseBookTM. 2005. Information obtained from MouseBook<sup>TM</sup>, Medical Research Council Mammalian Genetics Unit, Harwell, UK. Unpublished :. [MGI Ref ID J:169366]
Phillips RJS. 1966. A cis-trans position effect at the A locus of the house mouse. Genetics 54(2):485-95. [PubMed: 5968639] [MGI Ref ID J:5027]
Poole TW. 1982. The agouti suppressor (As) coat color mutation in mice: developmental effects on the expression of agouti locus alleles. J Exp Zool 220(1):57-64. [PubMed: 7077265] [MGI Ref ID J:6763]
Poole TW; Silvers WK. 1976. The development of regional pigmentation patterns in black and tan (at) mice. J Exp Zool 197(1):115-9. [PubMed: 781177] [MGI Ref ID J:5672]
SILVERS WK. 1958. An experimental approach to action of genes at the agouti locus in the mouse. III. Transplants of newborn Aw-, A-and at-skin to Ay-, Aw-, A-and aa hosts. J Exp Zool 137(1):189-96. [PubMed: 13563791] [MGI Ref ID J:13013]
Sandgren K; Larsson LT; Ekelund M; Robinsson D; Ekblad E. 1998. Functional and morphological examination of ganglionic and aganglionic distal gut from the lethal spotted mouse. Eur J Pediatr Surg 8(4):234-9. [PubMed: 9783148] [MGI Ref ID J:113064]
Silvers WK. 1979. The Coat Colors of Mice; A Model for Mammalian Gene Action and Interaction. In: The Coat Colors of Mice. Springer-Verlag, New York. [MGI Ref ID J:78801]
Summerhayes IC; Franks LM. 1979. Effects of donor age on neoplastic transformation of adult mouse bladder epithelium in vitro. J Natl Cancer Inst 62(4):1017-23. [PubMed: 107359] [MGI Ref ID J:56454]
Vrieling H; Duhl DM; Millar SE; Miller KA; Barsh GS. 1994. Differences in dorsal and ventral pigmentation result from regional expression of the mouse agouti gene. Proc Natl Acad Sci U S A 91(12):5667-71. [PubMed: 8202545] [MGI Ref ID J:18750]
Wolff GL. 1978. Influence of maternal phenotype on metabolic differentiation of agouti locus mutants in the mouse. Genetics 88(3):529-39. [PubMed: 640377] [MGI Ref ID J:5964]
FALCONER DS. 1954. Linkage in the mouse: the sex-linked genes and Rough. Z Indukt Abstamm Vererbungsl 86(2):263-8. [PubMed: 13227156] [MGI Ref ID J:247]
Graff RJ; Simmons D; Meyer J; Martin-Morgan D; Kurtz M. 1986. Abnormal bone production associated with mutant mouse genes pa and we. J Hered 77(2):109-13. [PubMed: 3711636] [MGI Ref ID J:8296]
Hertwig P. 1942. Neue Mutationen und Koppelungsgruppen bei der Hausmaus Z Indukt Abstamm Vererbungsl 80:220-246. [MGI Ref ID J:208]
Koniukhov BV; Kupriianov SD. 1990. [The mutant gene wellhaarig disturbs the differentiation of hair follicle cells in the mouse] Ontogenez 21(1):56-62. [PubMed: 1694022] [MGI Ref ID J:153649]
Koniukhov BV; Malinina NA; Martynov MIu. 2004. [The we gene is a modifier of the wal gene in mice] Genetika 40(7):968-74. [PubMed: 15458208] [MGI Ref ID J:153574]
Koniukhov BV; Vsevolodov EB; Sazhina MV. 1993. [An ultrastructural analysis of the cells of the outer root sheath of the hair follicles in mice of the wellhaarig mutant strain] Ontogenez 24(1):96-102. [PubMed: 8474761] [MGI Ref ID J:153577]
Martynova MIu; Isaev DA; Koniukhov BV. 2002. [Effects of the mutant gene wellhaarig in chimeric mice] Genetika 38(11):1511-7. [PubMed: 12500677] [MGI Ref ID J:153575]
SNELL GD; BUNKER HP. 1964. HISTOCOMPATIBILITY GENES OF MICE. IV. THE POSITION OF H-3 IN THE FIFTH LINKAGE GROUP. Transplantation 2:743-51. [PubMed: 14224656] [MGI Ref ID J:118]
Sundberg JP (ed.). 1994. Handbook of Mouse Mutations with Skin and Hair Abnormalities: Animal Models and Biomedical Tools. In: Handbook of Mouse Mutations with Skin and Hair Abnormalities: Animal Models and Biomedical Tools. CRC Press, Boca Raton. [MGI Ref ID J:30359]
Sweet HO; Davisson MT. 1995. Remutations at The Jackson Laboratory (Update to Mouse Genome 1993; 91:862-5 - J16313) Mouse Genome 93(4):1030-4. [MGI Ref ID J:30778]
Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.
Pricing and Purchasing
Pricing, Supply Level & Notes, Controls
| Pricing for USA, Canada and Mexico shipping destinations |
|
Cryopreserved
Cryopreserved Mice - Ready for Recovery
Animals Provided
Price (US dollars $) Cryorecovery* $3000.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Standard Supply
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.
Supply Notes
- Cryorecovery - Standard.
Progeny testing is not required.
The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 11 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).
| Pricing for International shipping destinations |
|
Cryopreserved
Cryopreserved Mice - Ready for Recovery
Animals Provided
Price (US dollars $) Cryorecovery* $3900.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Standard Supply
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.
Supply Notes
- Cryorecovery - Standard.
Progeny testing is not required.
The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 11 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).
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Standard Supply
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.
General Supply Notes
- Genomic DNA is available for this strain from the Mouse DNA Resource.
Control Information
| Control | ||
|---|---|---|
| Untyped from the colony | ||
| Considerations for Choosing Controls | ||
| Control Pricing Information for Genetically Engineered Mutant Strains. | ||
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering Information
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