JAX Mice Database - 000090 129S1/Sv-Oca2<+> Tyr<+> Kitl<Sl-J>/J

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Strain Name:	129S1/Sv-Oca2⁺ Tyr⁺ Kitl^Sl-J/J
Stock Number:	000090
Availability:	Repository-Cryopreserved

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General Terms and Conditions

Former Name	129S1/Sv-p⁺ Tyr⁺ Kitl^Sl-J/J (Changed: 11-FEB-08 )
	129S1/Sv-p⁺Tyr⁺Kitl^Sl-J (Changed: 03-FEB-06 )
	129/Sv-Sl^J/+ c⁺ p⁺/c⁺ p⁺ (Changed: 15-DEC-04 )
Genes & Alleles	Kitl; Kitl^Sl-J; Oca2; Oca2⁺; Tyr; Tyr⁺;

Product Information

Strain Details

Type JAX^® GEMM^® Strain - Mutant Strain

Additional information on JAX^® GEMM^® Strains.

Type JAX^® GEMM^® Strain - Spontaneous Mutation

Species laboratory mouse

Generation F12

Strain Description
The multiple steel mutations (Kitl^Sl) behave in a semidominant fashion and cause deficiencies in pigment cells, germ cells, and blood cells paralleling those caused by the Kit locus mutations (dominant spotting alleles). Most of the alleles at steel locus cause severe anemia in utero and death by 15 to 16 days of gestation in homozygous mutant mice. However, compounds of two steel mutants (e.g. Kitl^Sl/Kitl^Sl-d) are viable, black-eyed white, are usually sterile in one or both sexes, and have severe macrocytic anemia. Heterozygous steel mice have a diluted coat color with a small amount of white spotting, are viable and fertile, and may have a slight macrocytic anemia. Primordial germ cells are absent in the nonviable steel homozygotes and severely reduced in steel heterozygotes. Mast cells are virtually absent in skin and other tissues of steel mutant mice. Tumors tend to develop in germ-cell-deficient ovaries with advancing age. The steel-J mutation (Kitl^Sl-J) on this 129S1 genetic background increases the incidence of testicular teratomas to approximately 10%.

Gene & Allele Details

Allele Symbol		Kitl^Sl-J
Allele Name		steel Jackson
Common Name(s)		Sl^J;
Strain of Origin		C3HeB/FeHu
Gene Symbol and Name		Kitl, kit ligand
Chromosome		10
Gene Common Name(s)		Clo; Con; DKFZp686F2250; Gb; KL-1; Kl1; Kl2; MGF; Mgf; SCF; SF; SHEP7; SLF; Sl; Steel; Steel factor; cloud gray; contrasted; grizzle-belly; mast cell growth factor; steel; stem cell factor;

Allele Symbol		Oca2⁺
Allele Name		wild type
Gene Symbol and Name		Oca2, oculocutaneous albinism II
Chromosome		7
Gene Common Name(s)		BEY; BEY1; BEY2; BOCA; D15S12; D7H15S12; D7Icr28RN; D7Nic1; DNA segment, Chr 7, Institute for Cancer Research 28RN; DNA segment, Chr 7, Nicholls 1; DNA segment, Chr 7, human D15S12; EYCL; EYCL2; EYCL3; HCL3; P; PED; SHEP1; p; pink-eyed dilution;

Allele Symbol		Tyr⁺
Allele Name		wild type
Gene Symbol and Name		Tyr, tyrosinase
Chromosome		7
Gene Common Name(s)		C; OCA1A; OCAIA; SHEP3; albino; c; skc35; skin/coat color 35;

Control Information

	Control
	Wild-type from the colony
	002448 129S1/SvImJ

Considerations for Choosing Controls

Related Strains

Strains carrying Oca2⁺ allele

000091 129T1/Sv-Oca2⁺ Tyr^c-ch Dnd1^Ter/J

001279 129T1/Sv-Oca2⁺ Tyr^c-ch-Aft/J

000822 B6 x 129S1/SvEi Oca2⁺ Tyr⁺-Vsx2^or-J/J

000494 J.Cg-Oca2⁺ Tyr⁺ Lyst^bg/J

View Strains carrying Oca2⁺ (4 strains)

Strains carrying Tyr⁺ allele

005445 A.B6 Tyr⁺-Cyba^nmf333/J

005012 A.B6 Tyr⁺-Myo5a^d-l31J/J

002565 A.B6-Tyr⁺/J

000822 B6 x 129S1/SvEi Oca2⁺ Tyr⁺-Vsx2^or-J/J

000899 C.B6-Tyr⁺ Hbb^s/J

000494 J.Cg-Oca2⁺ Tyr⁺ Lyst^bg/J

002281 NFS.C58-Tyr⁺/J

004304 NOD.CBALs-Tyr⁺/LtJ

View Strains carrying Tyr⁺ (8 strains)

Strains carrying other alleles of Kitl

002993 B6.Cg-Kitl^Sl-18H/EiJ

000124 B6.Cg-Kitl^Sl Krt71^Ca/J

000160 B6.D2-Kitl^Sl-d/J

000291 C3FeLe.Cg-a/a Hm Kitl^Sl Krt71^Ca-J/J

001380 C3Sn.Cg-Kitl^Sl-con/J

003252 C57BL/6J-Kitl^Sl-20J/J

006839 C57BL/6J-Kitl^Sl-22J/J

000979 STOCK Kitl^Sl-16J/J

000161 WB.D2-Kitl^Sl-d/J

000693 WC/ReJ Kitl^Sl/J

100401 WCB6F1/J Kitl^Sl Kitl^Sl-d

View Strains carrying other alleles of Kitl (11 strains)

Strains carrying other alleles of Oca2

000004 ABP/LeJ

000577 B6 x STOCK a Oca2^p Hps5^ru2 Ednrb^s/J

001059 B6By.Cg-Oca2^p/J

002460 C3H/HeJ-Oca2^p-J Is(7;1)40H/J

000513 C3H/HeJ-Oca2^p-J/J

001136 C57BL/6J-Oca2^p-un+2J/J

001506 C57BL/6J-Oca2^p-un+3J/J

001810 C57BL/6J-Oca2^p-un+4J/J

001513 C57BL/6J-Oca2^p-un+5J/J

001499 C57BL/6J-Oca2^p-un+6J/J

001033 C57BL/6J-Oca2^p-un+J/J

000028 C57BL/6J-Oca2^p-un/J

000619 FS/EiJ

000306 STOCK Dll3^pu + Tyr^c-ch/+ Oca2^p Tyr^c-ch/J

001584 STOCK Oca2^p-J/Oca2^p-bs/J

001585 STOCK Oca2^p-d/Oca2^p-25H/J

000823 STOCK Oca2^p-d/Oca2^p-6H/J

001747 STOCK Oca2^p-d/Oca2^p-cp/J

001618 STOCK Oca2^p/Oca2^p Prop1^df/J

View Strains carrying other alleles of Oca2 (19 strains)

Strains carrying other alleles of Tyr

000091 129T1/Sv-Oca2⁺ Tyr^c-ch Dnd1^Ter/J

001279 129T1/Sv-Oca2⁺ Tyr^c-ch-Aft/J

000409 B10.129P-H1^b Hbb^d Tyr^c Ea7^a/(5M)oSnJ

000418 B10.129P-H1^b Tyr^c Hbb^d/(5M)nSnJ

000432 B10.C-H1^b Hbb^d Tyr^c/(41N)SnJ

000580 B10.D2/nSn-Tyr^c-4J/J

000578 B6 x STOCK Tyr^c-ch Bmp5^se +/+ Myo6^sv/J

000058 B6(Cg)-Tyr^c-2J/J

000383 B6.C-Tyr^c H1^b Hbb^d/ByJ

007484 B6.Cg-Tyr^c-2J Tg(Tyr)3412ARpw Tg(Sry-EGFP)92Ei/EiJ

000035 B6.Cg-Tyr^c-J/J

000104 B6.Cg-Tyr^c-h/J

000054 B6.D2-Tyr^c-p/J

000339 C3H/HeJ-Tyr^c-9J/J

001294 C3H/HeJ-Tyr^c-a/J

001002 C57BL/10SnJ-Tyr^c-11J/J

001006 CBA/J-Tyr^c-10J/J

000657 CE/J

000619 FS/EiJ

004828 FVB.129P2-Pde6b⁺ Tyr^c-ch/AntJ

007483 FVB.Cg-Tg(Tyr)3412ARpw Tg(Sry-EGFP)92Ei/EiJ

005115 NOD.FVB-Tg(INS-MT2A,Tyr)1Pne/PneJ

005114 NOD.FVB-Tg(Ins1-Cat,Tyr)25Pne/PneJ

000271 SH1/LeJ

001759 STOCK A Tyr^c Sha/J

000306 STOCK Dll3^pu + Tyr^c-ch/+ Oca2^p Tyr^c-ch/J

000006 STOCK Hk Tyr^c/J

000206 STOCK a/a Tyr^c-h/J

View Strains carrying other alleles of Tyr (28 strains)

Additional Web Information

JAX Notes, February 2001; 481. Mgf Gene Name Changes to Kitl.
New 129 Nomenclature Bulletin

Research Applications

This mouse can be used to support research in many areas including:

Kitl^Sl-J related

Cancer Research
Growth Factors/Receptors/Cytokines
Increased Tumor Incidence (Gonadal Tumors: ovarian and testicular)

Dermatology Research
Color and White Spotting Defects

Developmental Biology Research
Neural Crest Defects

Endocrine Deficiency Research
Bone/Bone Marrow Defects
Gonad Defects
Hypothalamus/Pituitary Defects
Skin Defects

Immunology and Inflammation Research
Growth Factors/Receptors/Cytokines
Immunodeficiency (Mast Cell Deficiency)
Immunodeficiency

Neurobiology Research
Vestibular and Hearing Defects

Reproductive Biology Research
Developmental Defects Affecting Gonads (germ cell deficient)
Fertility Defects
Gonadal Tumors (ovarian and testicular)

Research Tools
Immunology and Inflammation Research (Mast Cell Deficiency)

Sensorineural Research
Vestibular and Hearing Defects

Tyr⁺ related

Dermatology Research
Color and White Spotting Defects (oculocutaneous albinism, type I)

Mouse/Human Gene Homologs
albinism, tyrosine negative (wildtype)

References

Additional References

Price and Supply Information

Strain Name:	*129S1/Sv-Oca2⁺ Tyr⁺ Kitl^Sl-J/J*
Stock Number:	000090

Price Details

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Supply Details

Standard Supply	Repository-Cryopreserved. Must Be Recovered. Please refer to the Supply Notes for further information.
Supply Notes	Cryorecovery - Standard. The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two males and two females (two pairs) will be provided, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the delivery time to approximately 25 weeks. At least one member of each pair will be of known genotype and will carry the mutation if it is a mutant strain. Please note that pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Price represents a repository maintenance fee, which includes the cost of recovery of the strain from the cryopreservation resource and the periodic replacement of the frozen embryos used for recovery. *Cryorecovery to establish a Dedicated Supply for greater quantities of mice.* One to two pairs will be recovered to establish a Dedicated Supply of mice. Price by quotation. For more information on Dedicated Supply, please contact JAX^® Services: Tel: 800-422-6423 or 207-288-5845; Email: jaxservices@jax.org. Genomic DNA is available for this strain from the Mouse DNA Resource.
Licensing	See General Terms and Conditions below
Control Information	View Control Information in Strain Details.

General Terms and Conditions

View JAX^® Mice & Services Conditions of Use.

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

Ordering and Purchasing Information

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Contact Information
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Tel: 800.422.6423 or 207.288.5845
Fax: 207.288.6150
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Go to JAX^® Mice Query Form

000091	129T1/Sv-Oca2⁺ Tyr^c-ch Dnd1^Ter/J
001279	129T1/Sv-Oca2⁺ Tyr^c-ch-Aft/J
000822	B6 x 129S1/SvEi Oca2⁺ Tyr⁺-Vsx2^or-J/J
000494	J.Cg-Oca2⁺ Tyr⁺ Lyst^bg/J

005445	A.B6 Tyr⁺-Cyba^nmf333/J
005012	A.B6 Tyr⁺-Myo5a^d-l31J/J
002565	A.B6-Tyr⁺/J
000822	B6 x 129S1/SvEi Oca2⁺ Tyr⁺-Vsx2^or-J/J
000899	C.B6-Tyr⁺ Hbb^s/J
000494	J.Cg-Oca2⁺ Tyr⁺ Lyst^bg/J
002281	NFS.C58-Tyr⁺/J
004304	NOD.CBALs-Tyr⁺/LtJ

002993	B6.Cg-Kitl^Sl-18H/EiJ
000124	B6.Cg-Kitl^Sl Krt71^Ca/J
000160	B6.D2-Kitl^Sl-d/J
000291	C3FeLe.Cg-a/a Hm Kitl^Sl Krt71^Ca-J/J
001380	C3Sn.Cg-Kitl^Sl-con/J
003252	C57BL/6J-Kitl^Sl-20J/J
006839	C57BL/6J-Kitl^Sl-22J/J
000979	STOCK Kitl^Sl-16J/J
000161	WB.D2-Kitl^Sl-d/J
000693	WC/ReJ Kitl^Sl/J
100401	WCB6F1/J Kitl^Sl Kitl^Sl-d

000004	ABP/LeJ
000577	B6 x STOCK a Oca2^p Hps5^ru2 Ednrb^s/J
001059	B6By.Cg-Oca2^p/J
002460	C3H/HeJ-Oca2^p-J Is(7;1)40H/J
000513	C3H/HeJ-Oca2^p-J/J
001136	C57BL/6J-Oca2^p-un+2J/J
001506	C57BL/6J-Oca2^p-un+3J/J
001810	C57BL/6J-Oca2^p-un+4J/J
001513	C57BL/6J-Oca2^p-un+5J/J
001499	C57BL/6J-Oca2^p-un+6J/J
001033	C57BL/6J-Oca2^p-un+J/J
000028	C57BL/6J-Oca2^p-un/J
000619	FS/EiJ
000306	STOCK Dll3^pu + Tyr^c-ch/+ Oca2^p Tyr^c-ch/J
001584	STOCK Oca2^p-J/Oca2^p-bs/J
001585	STOCK Oca2^p-d/Oca2^p-25H/J
000823	STOCK Oca2^p-d/Oca2^p-6H/J
001747	STOCK Oca2^p-d/Oca2^p-cp/J
001618	STOCK Oca2^p/Oca2^p Prop1^df/J

Strain Name:

129S1/Sv-Oca2+ Tyr+ KitlSl-J/J

Stock Number:

000090

Availability:

Repository-Cryopreserved

General Terms and Conditions

Product Information

Strain Details

Gene & Allele Details

Control Information

Related Strains

Additional Web Information

Research Applications

References

Price and Supply Information

Price Details

*NO Shipping Destination selected!

Supply Details

General Terms and Conditions

The Jackson Laboratory's Genotype Promise

129S1/Sv-Oca2⁺ Tyr⁺ Kitl^Sl-J/J