Strain Name:

129T1/Sv-Oca2+ Tyrc-ch Dnd1Ter/J

Stock Number:

000091

Availability:

Repository-Cryopreserved

Description

Strain Information

Former Names 129T1/Sv-p+ Tyrc-ch Dnd1Ter/J    (Changed: 11-FEB-08 )
129T1/Sv-p+ Tyrc-ch Ter/J    (Changed: 27-JUN-05 )
129T1/Sv-+p Tyrc-ch Ter/+    (Changed: 15-DEC-04 )
Type Mutant Strain;
Specieslaboratory mouse
H2 Haplotypeb

Appearance
white bellied agouti chinchilla
Related Genotype: Aw/Aw,Tyrc-ch/Tyrc-ch

Development
This strain was derived from a 129 line (referred to as 129/Sv-WCP) congenic for dominant spotting (KitW) and chinchilla (Tyrc-ch). The congenic was developed from an F1 male (WC x C57BL/6) backcrossed to a 129/Sv female. At the 8th backcross generation, 20% of the males produced by a heterozygous female developed testicular teratomas. Subsequently, sibling matings were selected for the ability to produce males with a high teratoma incidence and the dominant spotting allele was bred out (Stevens LC, 1973, J Natl Cancer Inst). Teratoma incidence in this strain is now attributed to a combination of the spontaneous mutation Dnd1Ter and the 129 strain background. By 1972, the colony had reached 20 generations of inbreeding. This strain was obtained from LC Stevens at The Jackson Laboratory and was cryopreserved in 1989.

Control Information

  Control
   Untyped from the colony
   002065 129T2/SvEmsJ
 
  Considerations for Choosing Controls

Related Strains

View Strains carrying   Oca2+     (4 strains)

Strains carrying   Tyrc-ch allele
001279   129T1/Sv-Oca2+ Tyrc-ch-Aft/J
000578   B6 x STOCK Tyrc-ch Bmp5se +/+ Myo6sv/J
000619   FS/EiJ
004828   FVB.129P2-Pde6b+ Tyrc-ch/AntJ
000271   SH1/LeJ
000306   STOCK Dll3pu + Tyrc-ch/+ Oca2p Tyrc-ch/J
View Strains carrying   Tyrc-ch     (6 strains)

View Strains carrying other alleles of Oca2     (19 strains)

View Strains carrying other alleles of Tyr     (40 strains)

Additional Web Information

New 129 Nomenclature Bulletin

Phenotype

Phenotype Information

Mammalian Phenotype Terms assigned by genotype

The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.

Dnd1Ter/Dnd1+

        involves: 129S1/Sv * C57BL/6
  • reproductive system phenotype
  • decreased germ cell number (MGI Ref ID J:7954)
    • 23% (29/126) of mice from N1 heterozygotes bred to 129/Sv-Dnd1 heterozygotes are germ cell deficient; 29% (28/101) of mice from N2 heterozygotes bred to 129/Sv-Dnd1 heterozygotes are germ cell deficient
    • N1 intercrossing results in 20/100 offspring have germ cell deficiency
  • small ovary (MGI Ref ID J:7954)
    • seen in some mice of N3 backcross to B6
  • small testis (MGI Ref ID J:7954)
    • seen in some mice of N3 backcross to B6
  • tumorigenesis
  • testis tumor (MGI Ref ID J:7954)
    • incidence is reduced after backcrossing for several generations compared to coisogenic heterozygous mutants
    • testicular teratoma (MGI Ref ID J:7954)
      • incidence is reduced after backcrossing for several generations compared to coisogenic heterozygous mutants
  • endocrine/exocrine gland phenotype
  • small ovary (MGI Ref ID J:7954)
    • seen in some mice of N3 backcross to B6
  • small testis (MGI Ref ID J:7954)
    • seen in some mice of N3 backcross to B6

Dnd1Ter/Dnd1Ter

        involves: 129S1/Sv * C57BL/6
  • tumorigenesis
  • testicular teratoma (MGI Ref ID J:7954)
    • incidence is reduced after backcrossing for several generations compared to coisogenic mutants
    • 56% (10/18) N1 male homozygotes show teratomas; 26% of N2 homozygous males and 25% of N3 homozygotes develop teratomas

Research Applications

This mouse can be used to support research in many areas including:

Dnd1Ter related

Cancer Research
Increased Tumor Incidence (Gonadal Tumors: testicular teratomas)

Reproductive Biology Research
Gonadal Tumors (low incidence of testicular teratomas)

Tyrc-ch related

Dermatology Research
Color and White Spotting Defects

Developmental Biology Research
Neurodevelopmental Defects
Skeletal Defects

Mouse/Human Gene Homologs
albinism, tyrosine negative

Genes & Alleles

Gene & Allele Information

Allele Symbol Dnd1Ter
Allele Name teratoma
Common Name(s) Ter;
Strain of Origin129S1/Sv-Kit Oca2

Tyr

Gene Symbol and Name Dnd1, dead end homolog 1 (zebrafish)
Chromosome 18
Gene Common Name(s) BC034897; MGC34750; MGC:41452; RBMS4; Ter; cDNA sequence BC034897; teratoma;
Molecular Note A single C to T base change created a stop codon at amino acid residue 178 or residue 190 depending on the isoform. [MGI Ref ID J:98580]
 
Allele Symbol Oca2+
Allele Name wild type
Gene Symbol and Name Oca2, oculocutaneous albinism II
Chromosome 7
Gene Common Name(s) BEY; BEY1; BEY2; BOCA; D15S12; D7H15S12; D7Icr28RN; D7Nic1; DNA segment, Chr 7, Institute for Cancer Research 28RN; DNA segment, Chr 7, Nicholls 1; DNA segment, Chr 7, human D15S12; EYCL; EYCL2; EYCL3; HCL3; P; PED; SHEP1; p; pink-eyed dilution;
 
Allele Symbol Tyrc-ch
Allele Name chinchilla
Common Name(s) cch; cr;
Strain of Originfancier's stock
Gene Symbol and Name Tyr, tyrosinase
Chromosome 7
Gene Common Name(s) C; OCA1A; OCAIA; SHEP3; albino; c; skc35; skin/coat color 35;
Molecular Note The mutation in the chinchilla allele was found to be a G to A point mutation that results in an amino acid change at position 464 from alanine to threonine. [MGI Ref ID J:19279]

Genotyping

Genotyping Information

This strain will not have a genotyping protocol or one is not currently available.

Helpful Links

Optimizing PCR Protocols

References

References

Selected Reference(s)

Stevens LC. 1973. A new inbred subline of mice (129-terSv) with a high incidence of spontaneous congenital testicular teratomas. J Natl Cancer Inst 50(1):235-42. [PubMed: 4692863]  [MGI Ref ID J:29502]

Additional References

Dnd1Ter related

Asada Y; Varnum DS; Frankel WN; Nadeau JH. 1994. A mutation in the Ter gene causing increased susceptibility to testicular teratomas maps to mouse chromosome 18. Nat Genet 6(4):363-8. [PubMed: 8054975]  [MGI Ref ID J:17491]

Bhattacharya C; Aggarwal S; Zhu R; Kumar M; Zhao M; Meistrich ML; Matin A. 2007. The mouse dead-end gene isoform alpha is necessary for germ cell and embryonic viability. Biochem Biophys Res Commun 355(1):194-9. [PubMed: 17291453]  [MGI Ref ID J:118625]

Hammond S; Zhu R; Youngren KK; Lam J; Anderson P; Matin A. 2007. Chromosome X modulates incidence of testicular germ cell tumors in Ter mice. Mamm Genome 18(12):832-8. [PubMed: 18049836]  [MGI Ref ID J:132029]

Lam MY; Nadeau JH. 2003. Genetic control of susceptibility to spontaneous testicular germ cell tumors in mice. APMIS 111(1):184-90; discussion 191. [PubMed: 12752260]  [MGI Ref ID J:82965]

Matin A. 2007. What leads from dead-end? Cell Mol Life Sci 64(11):1317-22. [PubMed: 17464447]  [MGI Ref ID J:122476]

Matin A; Nadeau JH. 2005. Search for testicular cancer gene hits dead-end. Cell Cycle 4(9):1136-8. [PubMed: 16082220]  [MGI Ref ID J:101387]

Noguchi T; Noguchi M. 1985. A recessive mutation (ter) causing germ cell deficiency and a high incidence of congenital testicular teratomas in 129/Sv-ter mice. J Natl Cancer Inst 75(2):385-92. [PubMed: 3860691]  [MGI Ref ID J:7954]

Sakurai T; Iguchi T; Moriwaki K; Noguchi M. 1995. The ter mutation first causes primordial germ cell deficiency in ter/ter mouse embryos at 8 days of gestation. Dev Growth Differ 37(3):293-302.  [MGI Ref ID J:28119]

Youngren KK; Coveney D; Peng X; Bhattacharya C; Schmidt LS; Nickerson ML; Lamb BT; Deng JM; Behringer RR; Capel B; Rubin EM; Nadeau JH; Matin A. 2005. The Ter mutation in the dead end gene causes germ cell loss and testicular germ cell tumours. Nature 435(7040):360-4. [PubMed: 15902260]  [MGI Ref ID J:98580]

Oca2+ related
Mouse Genome Informatics (MGI). 2006. Information obtained from The RIKEN BioResource Center :.  [MGI Ref ID J:104881]

Tyrc-ch related
Beermann F; Ruppert S; Hummler E; Bosch FX; Muller G; Ruther U; Schutz G. 1990. Rescue of the albino phenotype by introduction of a functional tyrosinase gene into mice. EMBO J 9(9):2819-26. [PubMed: 2118105]  [MGI Ref ID J:19279]

Bhattacharya C; Aggarwal S; Zhu R; Kumar M; Zhao M; Meistrich ML; Matin A. 2007. The mouse dead-end gene isoform alpha is necessary for germ cell and embryonic viability. Biochem Biophys Res Commun 355(1):194-9. [PubMed: 17291453]  [MGI Ref ID J:118625]

Dunn LC. 1936. Studies on multiple allelomorphic series in the house mouse. I. Description of agouti and albino series of allelomorphs J Genet 33:443-53.  [MGI Ref ID J:22600]

Errijgers V; Van Dam D; Gantois I; Van Ginneken CJ; Grossman AW; D'Hooge R; De Deyn PP; Kooy RF. 2007. FVB.129P2-Pde6b(+) Tyr(c-ch)/Ant, a sighted variant of the FVB/N mouse strain suitable for behavioral analysis. Genes Brain Behav 6(6):552-7. [PubMed: 17083330]  [MGI Ref ID J:137779]

Feldman HW. 1935. A fifth allelomorph in the albino series of the house mouse J Mammal 16:207-210.  [MGI Ref ID J:83666]

Feldman HW. 1922. A fourth allelomorph in the albino series in mice Am Naturalist 56:573-574.  [MGI Ref ID J:14850]

Klebig ML; Kwon BS; Rinchik EM. 1992. Physical analysis of murine albino deletions that disrupt liver-specific gene regulation or mesoderm development. Mamm Genome 2(1):51-63. [PubMed: 1543902]  [MGI Ref ID J:1540]

Laiosa MD; Lai ZW; Thurmond TS; Fiore NC; DeRossi C; Holdener BC; Gasiewicz TA; Silverstone AE. 2002. 2,3,7,8-tetrachlorodibenzo-p-dioxin causes alterations in lymphocyte development and thymic atrophy in hemopoietic chimeras generated from mice deficient in ARNT2. Toxicol Sci 69(1):117-24. [PubMed: 12215665]  [MGI Ref ID J:113951]

Lamoreux ML; Wakamatsu K; Ito S. 2001. Interaction of major coat color gene functions in mice as studied by chemical analysis of eumelanin and pheomelanin. Pigment Cell Res 14(1):23-31. [PubMed: 11277491]  [MGI Ref ID J:103803]

Lossie AC; Nakamura H; Thomas SE; Justice MJ. 2005. Mutation of l7Rn3 shows that Odz4 is required for mouse gastrulation. Genetics 169(1):285-99. [PubMed: 15489520]  [MGI Ref ID J:96673]

Lyon MF. 1963. Attempts to test the inactive-X theory of dosage compensation in mammals Genet Res 4:93-103.  [MGI Ref ID J:272]

Moyer FH. 1966. Genetic variations in the fine structure and ontogeny of mouse melanin granules. Am Zool 6(1):43-66. [PubMed: 5902512]  [MGI Ref ID J:5001]

Schedl A; Ruppert S; Kelsey G; Thies E; Niswander L; Magnuson T; Klebig ML; Rinchik EM; Schutz G. 1992. Chromosome jumping from flanking markers defines the minimal region for alf/hsdr-1 within the albino-deletion complex. Genomics 14(2):288-97. [PubMed: 1427845]  [MGI Ref ID J:2638]

Silvers WK. 1979. The Coat Colors of Mice; A Model for Mammalian Gene Action and Interaction. In: The Coat Colors of Mice. Springer-Verlag, New York.  [MGI Ref ID J:78801]

Takeuchi S; Yamamoto H; Takeuchi T. 1988. Expression of tyrosinase gene in mice Genome 30(Suppl 1):260 (Abstr.).  [MGI Ref ID J:30744]

Townsend D; Witkop CJ Jr; Mattson J. 1981. Tyrosinase subcellular distribution and kinetic parameters in wild type and C-locus mutant C57BL/6J mice. J Exp Zool 216(1):113-9. [PubMed: 6793688]  [MGI Ref ID J:6611]

Vasiliou V; Buetler T; Eaton DL; Nebert DW. 2000. Comparison of oxidative stress response parameters in newborn mouse liver versus simian virus 40 (SV40)-transformed hepatocyte cell lines. Biochem Pharmacol 59(6):703-12. [PubMed: 10677587]  [MGI Ref ID J:60274]

Vasiliou V; Reuter SF; Nebert DW. 1997. Extrahepatic expression of NAD(P)H:menadione oxidoreductase, UDP glucuronosyltransferase-1A6, microsomal aldehyde dehydrogenase, and hepatic nuclear factor-1 alpha mRNAs in ch/ch and 14CoS/14CoS mice. Biochem Biophys Res Commun 233(3):631-6. [PubMed: 9168903]  [MGI Ref ID J:40515]

Health & husbandry

Health & Colony Maintenance Information

Currently there no information available for this strain. This may be due to the supply level of this strain.

Purchasing information

Pricing, Supply Level & Notes, Controls, General Terms & Conditions

Pricing

Pricing for USA, Canada and Mexico shipping destinations             View   International   Pricing
Weeks of AgePrice*Gender
Cryorecovery Fee $1900.00
*Price(s) in US dollars ($)

Supply Details

Standard SupplyRepository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information.
Supply Notes
  • Cryorecovery - Standard.
    The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two males and two females (two pairs) will be provided, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the delivery time to approximately 25 weeks. At least one member of each pair will be of known genotype and will carry the mutation if it is a mutant strain. Please note that pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Price represents a repository maintenance fee, which includes the cost of recovery of the strain from the cryopreservation resource and the periodic replacement of the frozen embryos used for recovery.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
    One to two pairs will be recovered to establish a Dedicated Supply of mice. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 or 1-207-288-5845.

  • Genomic DNA is available for this strain from the Mouse DNA Resource.

Pricing for International shipping destinations             View   USA, Canada and Mexico   Pricing
Weeks of AgePrice*Gender
Cryorecovery Fee $2470.00
*Price(s) in US dollars ($)

Supply Details

Standard SupplyRepository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information.
Supply Notes
  • Cryorecovery - Standard.
    The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two males and two females (two pairs) will be provided, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the delivery time to approximately 25 weeks. At least one member of each pair will be of known genotype and will carry the mutation if it is a mutant strain. Please note that pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Price represents a repository maintenance fee, which includes the cost of recovery of the strain from the cryopreservation resource and the periodic replacement of the frozen embryos used for recovery.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
    One to two pairs will be recovered to establish a Dedicated Supply of mice. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 or 1-207-288-5845.

  • Genomic DNA is available for this strain from the Mouse DNA Resource.

Control Information

  Control
   Untyped from the colony
   002065 129T2/SvEmsJ
 
  Considerations for Choosing Controls
  USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains.
  International - Control Pricing Information for Genetically Engineered Mutant Strains.

General Terms and Conditions

View JAX® Mice & Services Conditions of Use.

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
Ordering and Purchasing Information

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Contact Information
Orders & Technical Support
Tel: 800.422.6423 or 207.288.5845
Fax: 207.288.6150
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