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Former Names 129T1/Sv-p+ Tyrc-ch Dnd1Ter/J (Changed: 11-FEB-08 ) 129T1/Sv-p+ Tyrc-ch Ter/J (Changed: 27-JUN-05 ) 129T1/Sv-+p Tyrc-ch Ter/+ (Changed: 15-DEC-04 ) Type Mutant Strain; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Species laboratory mouse H2 Haplotype b Generation F39pF5p (08-JAN-04) Appearance
white bellied agouti chinchilla
Related Genotype: Aw/Aw,Tyrc-ch/Tyrc-chDevelopment
This strain was derived from a 129 line (referred to as 129/Sv-WCP) congenic for dominant spotting (KitW) and chinchilla (Tyrc-ch). The congenic was developed from an F1 male (WC x C57BL/6) backcrossed to a 129/Sv female. At the 8th backcross generation, 20% of the males produced by a heterozygous female developed testicular teratomas. Subsequently, sibling matings were selected for the ability to produce males with a high teratoma incidence and the dominant spotting allele was bred out (Stevens LC, 1973, J Natl Cancer Inst). Teratoma incidence in this strain is now attributed to a combination of the spontaneous mutation Dnd1Ter and the 129 strain background. By 1972, the colony had reached 20 generations of inbreeding. This strain was obtained from LC Stevens at The Jackson Laboratory and was cryopreserved in 1989.
| Control | ||
|---|---|---|
| Untyped from the colony | ||
| 002065 129T2/SvEmsJ | ||
| Considerations for Choosing Controls | ||
Strains carrying Oca2+ allele
000090 129S1/Sv-Oca2+ Tyr+ KitlSl-J/J 001279 129T1/Sv-Oca2+ Tyrc-ch-Aft/J 000822 B6 x 129S1/SvEi Oca2+ Tyr+-Vsx2or-J/J 000494 J.Cg-Oca2+ Tyr+ Lystbg/J View Strains carrying Oca2+ (4 strains)
Strains carrying Tyrc-ch allele
001279 129T1/Sv-Oca2+ Tyrc-ch-Aft/J 000578 B6 x STOCK Tyrc-ch Bmp5se +/+ Myo6sv/J 000619 FS/EiJ 004828 FVB.129P2-Pde6b+ Tyrc-ch/AntJ 000271 SH1/LeJ 000306 STOCK Dll3pu + Tyrc-ch/+ Oca2p Tyrc-ch/J View Strains carrying Tyrc-ch (6 strains)
Strains carrying other alleles of Oca2
000004 ABP/LeJ 000577 B6 x STOCK a Oca2p Hps5ru2 Ednrbs/J 001059 B6By.Cg-Oca2p/J 002460 C3H/HeJ-Oca2p-J Is(7;1)40H/J 000513 C3H/HeJ-Oca2p-J/J 001136 C57BL/6J-Oca2p-un+2J/J 001506 C57BL/6J-Oca2p-un+3J/J 001810 C57BL/6J-Oca2p-un+4J/J 001513 C57BL/6J-Oca2p-un+5J/J 001499 C57BL/6J-Oca2p-un+6J/J 001033 C57BL/6J-Oca2p-un+J/J 000028 C57BL/6J-Oca2p-un/J 000619 FS/EiJ 000306 STOCK Dll3pu + Tyrc-ch/+ Oca2p Tyrc-ch/J 001584 STOCK Oca2p-J/Oca2p-bs/J 001585 STOCK Oca2p-d/Oca2p-25H/J 000823 STOCK Oca2p-d/Oca2p-6H/J 001747 STOCK Oca2p-d/Oca2p-cp/J 001618 STOCK Oca2p/Oca2p Prop1df/J View Strains carrying other alleles of Oca2 (19 strains)
Strains carrying other alleles of Tyr
View Strains carrying other alleles of Tyr (40 strains)
New 129 Nomenclature Bulletin
View Mammalian Phenotype Terms
Mammalian Phenotype Terms
assigned by genotype
The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.
Dnd1Ter/Dnd1+
involves: 129S1/Sv * C57BL/6
- reproductive system phenotype
- decreased germ cell number (MGI Ref ID J:7954)
- 23% (29/126) of mice from N1 heterozygotes bred to 129/Sv-Dnd1
heterozygotes are germ cell deficient; 29% (28/101) of mice from N2 heterozygotes bred to 129/Sv-Dnd1 heterozygotes are germ cell deficient - N1 intercrossing results in 20/100 offspring have germ cell deficiency
- small ovary (MGI Ref ID J:7954)
- seen in some mice of N3 backcross to B6
- small testis (MGI Ref ID J:7954)
- seen in some mice of N3 backcross to B6
- tumorigenesis
- testis tumor (MGI Ref ID J:7954)
- incidence is reduced after backcrossing for several generations compared to coisogenic heterozygous mutants
- testicular teratoma (MGI Ref ID J:7954)
- incidence is reduced after backcrossing for several generations compared to coisogenic heterozygous mutants
- endocrine/exocrine gland phenotype
- small ovary (MGI Ref ID J:7954)
- seen in some mice of N3 backcross to B6
- small testis (MGI Ref ID J:7954)
- seen in some mice of N3 backcross to B6
Dnd1Ter/Dnd1Ter
involves: 129S1/Sv * C57BL/6
- tumorigenesis
- testicular teratoma (MGI Ref ID J:7954)
- incidence is reduced after backcrossing for several generations compared to coisogenic mutants
- 56% (10/18) N1 male homozygotes show teratomas; 26% of N2 homozygous males and 25% of N3 homozygotes develop teratomas
View Research Applications
Research Applications
This mouse can be used to support research in many areas including:Dnd1Ter related
Tyrc-ch relatedCancer Research
Increased Tumor Incidence
Gonadal Tumors: testicular teratomas
Reproductive Biology Research
Gonadal Tumors
low incidence of testicular teratomas
Dermatology Research
Color and White Spotting Defects
Developmental Biology Research
Neurodevelopmental Defects
Skeletal Defects
Mouse/Human Gene Homologs
albinism, tyrosine negative
| Allele Symbol | Dnd1Ter | ||
|---|---|---|---|
| Allele Name | teratoma | ||
| Allele Type | Spontaneous | ||
| Common Name(s) | Ter; | ||
| Strain of Origin | 129S1/Sv-Kit Tyr | ||
| Gene Symbol and Name | Dnd1, dead end homolog 1 (zebrafish) | ||
| Chromosome | 18 | ||
| Gene Common Name(s) | BC034897; MGC34750; MGC:41452; RBMS4; Ter; cDNA sequence BC034897; teratoma; | ||
| Molecular Note | A single C to T base change created a stop codon at amino acid residue 178 or residue 190 depending on the isoform. [MGI Ref ID J:98580] | ||
| Allele Symbol | Oca2+ | ||
| Allele Name | wild type | ||
| Allele Type | Not Specified | ||
| Gene Symbol and Name | Oca2, oculocutaneous albinism II | ||
| Chromosome | 7 | ||
| Gene Common Name(s) | BEY; BEY1; BEY2; BOCA; D15S12; D7H15S12; D7Icr28RN; D7Nic1; DNA segment, Chr 7, Institute for Cancer Research 28RN; DNA segment, Chr 7, Nicholls 1; DNA segment, Chr 7, human D15S12; EYCL; EYCL2; EYCL3; HCL3; P; PED; SHEP1; p; pink-eyed dilution; | ||
| Allele Symbol | Tyrc-ch | ||
| Allele Name | chinchilla | ||
| Allele Type | Spontaneous | ||
| Common Name(s) | cch; cr; | ||
| Strain of Origin | fancier's stock | ||
| Gene Symbol and Name | Tyr, tyrosinase | ||
| Chromosome | 7 | ||
| Gene Common Name(s) | C; OCA1A; OCAIA; SHEP3; albino; c; skc35; skin/coat color 35; | ||
| Molecular Note | The mutation in the chinchilla allele was found to be a G to A point mutation that results in an amino acid change at position 464 from alanine to threonine. [MGI Ref ID J:19279] | ||
Genotyping Protocols
Dnd1Ter, Restriction Enzyme Digest
Helpful Links
Genotyping resources and troubleshooting
Stevens LC. 1973. A new inbred subline of mice (129-terSv) with a high incidence of spontaneous congenital testicular teratomas. J Natl Cancer Inst 50(1):235-42. [PubMed: 4692863] [MGI Ref ID J:29502]
Dnd1Ter relatedOca2+ relatedAnderson PD; Lam MY; Poirier C; Bishop CE; Nadeau JH. 2009. The role of the mouse y chromosome on susceptibility to testicular germ cell tumors. Cancer Res 69(8):3614-8. [PubMed: 19351821] [MGI Ref ID J:147731]
Asada Y; Varnum DS; Frankel WN; Nadeau JH. 1994. A mutation in the Ter gene causing increased susceptibility to testicular teratomas maps to mouse chromosome 18. Nat Genet 6(4):363-8. [PubMed: 8054975] [MGI Ref ID J:17491]
Bhattacharya C; Aggarwal S; Zhu R; Kumar M; Zhao M; Meistrich ML; Matin A. 2007. The mouse dead-end gene isoform alpha is necessary for germ cell and embryonic viability. Biochem Biophys Res Commun 355(1):194-9. [PubMed: 17291453] [MGI Ref ID J:118625]
Cook MS; Coveney D; Batchvarov I; Nadeau JH; Capel B. 2009. BAX-mediated cell death affects early germ cell loss and incidence of testicular teratomas in Dnd1(Ter/Ter) mice. Dev Biol 328(2):377-83. [PubMed: 19389346] [MGI Ref ID J:149469]
Hammond S; Zhu R; Youngren KK; Lam J; Anderson P; Matin A. 2007. Chromosome X modulates incidence of testicular germ cell tumors in Ter mice. Mamm Genome 18(12):832-8. [PubMed: 18049836] [MGI Ref ID J:132029]
Lam MY; Heaney JD; Youngren KK; Kawasoe JH; Nadeau JH. 2007. Trans-generational epistasis between Dnd1Ter and other modifier genes controls susceptibility to testicular germ cell tumors. Hum Mol Genet 16(18):2233-40. [PubMed: 17616517] [MGI Ref ID J:143392]
Lam MY; Nadeau JH. 2003. Genetic control of susceptibility to spontaneous testicular germ cell tumors in mice. APMIS 111(1):184-90; discussion 191. [PubMed: 12752260] [MGI Ref ID J:82965]
Matin A. 2007. What leads from dead-end? Cell Mol Life Sci 64(11):1317-22. [PubMed: 17464447] [MGI Ref ID J:122476]
Matin A; Nadeau JH. 2005. Search for testicular cancer gene hits dead-end. Cell Cycle 4(9):1136-8. [PubMed: 16082220] [MGI Ref ID J:101387]
Noguchi T; Noguchi M. 1985. A recessive mutation (ter) causing germ cell deficiency and a high incidence of congenital testicular teratomas in 129/Sv-ter mice. J Natl Cancer Inst 75(2):385-92. [PubMed: 3860691] [MGI Ref ID J:7954]
Sakurai T; Iguchi T; Moriwaki K; Noguchi M. 1995. The ter mutation first causes primordial germ cell deficiency in ter/ter mouse embryos at 8 days of gestation. Dev Growth Differ 37(3):293-302. [MGI Ref ID J:28119]
Youngren KK; Coveney D; Peng X; Bhattacharya C; Schmidt LS; Nickerson ML; Lamb BT; Deng JM; Behringer RR; Capel B; Rubin EM; Nadeau JH; Matin A. 2005. The Ter mutation in the dead end gene causes germ cell loss and testicular germ cell tumours. Nature 435(7040):360-4. [PubMed: 15902260] [MGI Ref ID J:98580]
Tyrc-ch relatedMouse Genome Informatics (MGI). 2006. Information obtained from The RIKEN BioResource Center :. [MGI Ref ID J:104881]
Anderson PD; Lam MY; Poirier C; Bishop CE; Nadeau JH. 2009. The role of the mouse y chromosome on susceptibility to testicular germ cell tumors. Cancer Res 69(8):3614-8. [PubMed: 19351821] [MGI Ref ID J:147731]
Beermann F; Ruppert S; Hummler E; Bosch FX; Muller G; Ruther U; Schutz G. 1990. Rescue of the albino phenotype by introduction of a functional tyrosinase gene into mice. EMBO J 9(9):2819-26. [PubMed: 2118105] [MGI Ref ID J:19279]
Bhattacharya C; Aggarwal S; Zhu R; Kumar M; Zhao M; Meistrich ML; Matin A. 2007. The mouse dead-end gene isoform alpha is necessary for germ cell and embryonic viability. Biochem Biophys Res Commun 355(1):194-9. [PubMed: 17291453] [MGI Ref ID J:118625]
Dunn LC. 1936. Studies on multiple allelomorphic series in the house mouse. I. Description of agouti and albino series of allelomorphs J Genet 33:443-53. [MGI Ref ID J:22600]
Errijgers V; Van Dam D; Gantois I; Van Ginneken CJ; Grossman AW; D'Hooge R; De Deyn PP; Kooy RF. 2007. FVB.129P2-Pde6b(+) Tyr(c-ch)/Ant, a sighted variant of the FVB/N mouse strain suitable for behavioral analysis. Genes Brain Behav 6(6):552-7. [PubMed: 17083330] [MGI Ref ID J:137779]
Feldman HW. 1935. A fifth allelomorph in the albino series of the house mouse J Mammal 16:207-210. [MGI Ref ID J:83666]
Feldman HW. 1922. A fourth allelomorph in the albino series in mice Am Naturalist 56:573-574. [MGI Ref ID J:14850]
Klebig ML; Kwon BS; Rinchik EM. 1992. Physical analysis of murine albino deletions that disrupt liver-specific gene regulation or mesoderm development. Mamm Genome 2(1):51-63. [PubMed: 1543902] [MGI Ref ID J:1540]
Laiosa MD; Lai ZW; Thurmond TS; Fiore NC; DeRossi C; Holdener BC; Gasiewicz TA; Silverstone AE. 2002. 2,3,7,8-tetrachlorodibenzo-p-dioxin causes alterations in lymphocyte development and thymic atrophy in hemopoietic chimeras generated from mice deficient in ARNT2. Toxicol Sci 69(1):117-24. [PubMed: 12215665] [MGI Ref ID J:113951]
Lamoreux ML; Wakamatsu K; Ito S. 2001. Interaction of major coat color gene functions in mice as studied by chemical analysis of eumelanin and pheomelanin. Pigment Cell Res 14(1):23-31. [PubMed: 11277491] [MGI Ref ID J:103803]
Lossie AC; Nakamura H; Thomas SE; Justice MJ. 2005. Mutation of l7Rn3 shows that Odz4 is required for mouse gastrulation. Genetics 169(1):285-99. [PubMed: 15489520] [MGI Ref ID J:96673]
Lyon MF. 1963. Attempts to test the inactive-X theory of dosage compensation in mammals Genet Res 4:93-103. [MGI Ref ID J:272]
Moyer FH. 1966. Genetic variations in the fine structure and ontogeny of mouse melanin granules. Am Zool 6(1):43-66. [PubMed: 5902512] [MGI Ref ID J:5001]
RUSSELL ES. 1949. A quantitative histological study of the pigment found in the coat-color mutants of the house mouse; interdependence among the variable granule attributes. Genetics 34(2):133-45. [PubMed: 18117146] [MGI Ref ID J:148461]
Russell ES. 1948. A Quantitative Histological Study of the Pigment Found in the Coat Color Mutants of the House Mouse. II. Estimates of the Total Volume of Pigment. Genetics 33(3):228-36. [PubMed: 17247280] [MGI Ref ID J:148462]
Russell ES. 1946. A Quantitative Histological Study of the Pigment Found in the Coat-Color Mutants of the House Mouse. I. Variable Attributes of the Pigment Granules. Genetics 31(3):327-46. [PubMed: 17247200] [MGI Ref ID J:148463]
Schedl A; Ruppert S; Kelsey G; Thies E; Niswander L; Magnuson T; Klebig ML; Rinchik EM; Schutz G. 1992. Chromosome jumping from flanking markers defines the minimal region for alf/hsdr-1 within the albino-deletion complex. Genomics 14(2):288-97. [PubMed: 1427845] [MGI Ref ID J:2638]
Silvers WK. 1979. The Coat Colors of Mice; A Model for Mammalian Gene Action and Interaction. In: The Coat Colors of Mice. Springer-Verlag, New York. [MGI Ref ID J:78801]
Sweet HO. 1987. Acromelanic (c<a>) Mouse News Lett 78:56. [MGI Ref ID J:14994]
Takeuchi S; Yamamoto H; Takeuchi T. 1988. Expression of tyrosinase gene in mice Genome 30(Suppl 1):260 (Abstr.). [MGI Ref ID J:30744]
Townsend D; Witkop CJ Jr; Mattson J. 1981. Tyrosinase subcellular distribution and kinetic parameters in wild type and C-locus mutant C57BL/6J mice. J Exp Zool 216(1):113-9. [PubMed: 6793688] [MGI Ref ID J:6611]
Vasiliou V; Buetler T; Eaton DL; Nebert DW. 2000. Comparison of oxidative stress response parameters in newborn mouse liver versus simian virus 40 (SV40)-transformed hepatocyte cell lines. Biochem Pharmacol 59(6):703-12. [PubMed: 10677587] [MGI Ref ID J:60274]
Vasiliou V; Reuter SF; Nebert DW. 1997. Extrahepatic expression of NAD(P)H:menadione oxidoreductase, UDP glucuronosyltransferase-1A6, microsomal aldehyde dehydrogenase, and hepatic nuclear factor-1 alpha mRNAs in ch/ch and 14CoS/14CoS mice. Biochem Biophys Res Commun 233(3):631-6. [PubMed: 9168903] [MGI Ref ID J:40515]
Currently there no information available for this strain. This may be due to the supply level of this strain.
| Pricing for USA, Canada and Mexico shipping destinations |
|
Animals Provided
Price (US dollars $) Cryorecovery Fee $1900.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
| Pricing for International shipping destinations |
|
Animals Provided
Price (US dollars $) Cryorecovery Fee $2470.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
| Standard Supply | Cryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information. |
|---|---|
| Supply Notes |
|
| Control | ||
|---|---|---|
| Untyped from the colony | ||
| 002065 129T2/SvEmsJ | ||
| Considerations for Choosing Controls | ||
| USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
| International - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
Purchasing Information
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| phone: | 207-288-6470 |
| fax: | 207-288-6655 |
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