Strain Name:

129T1/Sv-Oca2+ Tyrc-ch Dnd1Ter/J

Stock Number:

000091

Availability:

Cryopreserved - Ready for recovery

Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Former Names 129T1/Sv-p+ Tyrc-ch Dnd1Ter/J    (Changed: 11-FEB-08 )
129T1/Sv-p+ Tyrc-ch Ter/J    (Changed: 27-JUN-05 )
129T1/Sv-+p Tyrc-ch Ter/+    (Changed: 15-DEC-04 )
Type Mutant Strain;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Specieslaboratory mouse
H2 Haplotypeb
GenerationF39pF5p (08-JAN-04)

Appearance
white bellied agouti chinchilla
Related Genotype: Aw/Aw,Tyrc-ch/Tyrc-ch

Development
This strain was derived from a 129 line (referred to as 129/Sv-WCP) congenic for dominant spotting (KitW) and chinchilla (Tyrc-ch). The congenic was developed from an F1 male (WC x C57BL/6) backcrossed to a 129/Sv female. At the 8th backcross generation, 20% of the males produced by a heterozygous female developed testicular teratomas. Subsequently, sibling matings were selected for the ability to produce males with a high teratoma incidence and the dominant spotting allele was bred out (Stevens LC, 1973, J Natl Cancer Inst). Teratoma incidence in this strain is now attributed to a combination of the spontaneous mutation Dnd1Ter and the 129 strain background. By 1972, the colony had reached 20 generations of inbreeding. This strain was obtained from LC Stevens at The Jackson Laboratory and was cryopreserved in 1989.

Control Information

  Control
   Untyped from the colony
   002065 129T2/SvEmsJ
 
  Considerations for Choosing Controls

Related Strains

View Strains carrying   Oca2+     (4 strains)

Strains carrying   Tyrc-ch allele
001279   129T1/Sv-Oca2+ Tyrc-ch-Aft/J
000578   B6 x STOCK Tyrc-ch Bmp5se +/+ Myo6sv/J
000619   FS/EiJ
004828   FVB.129P2-Pde6b+ Tyrc-ch/AntJ
000271   SH1/LeJ
000306   STOCK Dll3pu + Tyrc-ch/+ Oca2p Tyrc-ch/J
View Strains carrying   Tyrc-ch     (6 strains)

View Strains carrying other alleles of Oca2     (19 strains)

View Strains carrying other alleles of Tyr     (40 strains)

Additional Web Information

New 129 Nomenclature Bulletin

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms
      assigned by genotype

The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.

Dnd1Ter/Dnd1+

        involves: 129S1/Sv * C57BL/6
  • reproductive system phenotype
  • decreased germ cell number (MGI Ref ID J:7954)
    • 23% (29/126) of mice from N1 heterozygotes bred to 129/Sv-Dnd1 heterozygotes are germ cell deficient; 29% (28/101) of mice from N2 heterozygotes bred to 129/Sv-Dnd1 heterozygotes are germ cell deficient
    • N1 intercrossing results in 20/100 offspring have germ cell deficiency
  • small ovary (MGI Ref ID J:7954)
    • seen in some mice of N3 backcross to B6
  • small testis (MGI Ref ID J:7954)
    • seen in some mice of N3 backcross to B6
  • tumorigenesis
  • testis tumor (MGI Ref ID J:7954)
    • incidence is reduced after backcrossing for several generations compared to coisogenic heterozygous mutants
    • testicular teratoma (MGI Ref ID J:7954)
      • incidence is reduced after backcrossing for several generations compared to coisogenic heterozygous mutants
  • endocrine/exocrine gland phenotype
  • small ovary (MGI Ref ID J:7954)
    • seen in some mice of N3 backcross to B6
  • small testis (MGI Ref ID J:7954)
    • seen in some mice of N3 backcross to B6

Dnd1Ter/Dnd1Ter

        involves: 129S1/Sv * C57BL/6
  • tumorigenesis
  • testicular teratoma (MGI Ref ID J:7954)
    • incidence is reduced after backcrossing for several generations compared to coisogenic mutants
    • 56% (10/18) N1 male homozygotes show teratomas; 26% of N2 homozygous males and 25% of N3 homozygotes develop teratomas
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Dnd1Ter related

Cancer Research
Increased Tumor Incidence
      Gonadal Tumors: testicular teratomas

Reproductive Biology Research
Gonadal Tumors
      low incidence of testicular teratomas

Tyrc-ch related

Dermatology Research
Color and White Spotting Defects

Developmental Biology Research
Neurodevelopmental Defects
Skeletal Defects

Mouse/Human Gene Homologs
albinism, tyrosine negative

Genes & Alleles

Gene & Allele Information

 
Allele Symbol Dnd1Ter
Allele Name teratoma
Allele Type Spontaneous
Common Name(s) Ter;
Strain of Origin129S1/Sv-Kit Oca2

Tyr

Gene Symbol and Name Dnd1, dead end homolog 1 (zebrafish)
Chromosome 18
Gene Common Name(s) BC034897; MGC34750; MGC:41452; RBMS4; Ter; cDNA sequence BC034897; teratoma;
Molecular Note A single C to T base change created a stop codon at amino acid residue 178 or residue 190 depending on the isoform. [MGI Ref ID J:98580]
 
Allele Symbol Oca2+
Allele Name wild type
Allele Type Not Specified
Gene Symbol and Name Oca2, oculocutaneous albinism II
Chromosome 7
Gene Common Name(s) BEY; BEY1; BEY2; BOCA; D15S12; D7H15S12; D7Icr28RN; D7Nic1; DNA segment, Chr 7, Institute for Cancer Research 28RN; DNA segment, Chr 7, Nicholls 1; DNA segment, Chr 7, human D15S12; EYCL; EYCL2; EYCL3; HCL3; P; PED; SHEP1; p; pink-eyed dilution;
 
Allele Symbol Tyrc-ch
Allele Name chinchilla
Allele Type Spontaneous
Common Name(s) cch; cr;
Strain of Originfancier's stock
Gene Symbol and Name Tyr, tyrosinase
Chromosome 7
Gene Common Name(s) C; OCA1A; OCAIA; SHEP3; albino; c; skc35; skin/coat color 35;
Molecular Note The mutation in the chinchilla allele was found to be a G to A point mutation that results in an amino acid change at position 464 from alanine to threonine. [MGI Ref ID J:19279]

Genotyping

Genotyping Information

Genotyping Protocols

Dnd1Ter, Restriction Enzyme Digest

Helpful Links

Genotyping resources and troubleshooting

References

References

Selected Reference(s)

Stevens LC. 1973. A new inbred subline of mice (129-terSv) with a high incidence of spontaneous congenital testicular teratomas. J Natl Cancer Inst 50(1):235-42. [PubMed: 4692863]  [MGI Ref ID J:29502]

Additional References

Dnd1Ter related

Anderson PD; Lam MY; Poirier C; Bishop CE; Nadeau JH. 2009. The role of the mouse y chromosome on susceptibility to testicular germ cell tumors. Cancer Res 69(8):3614-8. [PubMed: 19351821]  [MGI Ref ID J:147731]

Asada Y; Varnum DS; Frankel WN; Nadeau JH. 1994. A mutation in the Ter gene causing increased susceptibility to testicular teratomas maps to mouse chromosome 18. Nat Genet 6(4):363-8. [PubMed: 8054975]  [MGI Ref ID J:17491]

Bhattacharya C; Aggarwal S; Zhu R; Kumar M; Zhao M; Meistrich ML; Matin A. 2007. The mouse dead-end gene isoform alpha is necessary for germ cell and embryonic viability. Biochem Biophys Res Commun 355(1):194-9. [PubMed: 17291453]  [MGI Ref ID J:118625]

Cook MS; Coveney D; Batchvarov I; Nadeau JH; Capel B. 2009. BAX-mediated cell death affects early germ cell loss and incidence of testicular teratomas in Dnd1(Ter/Ter) mice. Dev Biol 328(2):377-83. [PubMed: 19389346]  [MGI Ref ID J:149469]

Hammond S; Zhu R; Youngren KK; Lam J; Anderson P; Matin A. 2007. Chromosome X modulates incidence of testicular germ cell tumors in Ter mice. Mamm Genome 18(12):832-8. [PubMed: 18049836]  [MGI Ref ID J:132029]

Lam MY; Heaney JD; Youngren KK; Kawasoe JH; Nadeau JH. 2007. Trans-generational epistasis between Dnd1Ter and other modifier genes controls susceptibility to testicular germ cell tumors. Hum Mol Genet 16(18):2233-40. [PubMed: 17616517]  [MGI Ref ID J:143392]

Lam MY; Nadeau JH. 2003. Genetic control of susceptibility to spontaneous testicular germ cell tumors in mice. APMIS 111(1):184-90; discussion 191. [PubMed: 12752260]  [MGI Ref ID J:82965]

Matin A. 2007. What leads from dead-end? Cell Mol Life Sci 64(11):1317-22. [PubMed: 17464447]  [MGI Ref ID J:122476]

Matin A; Nadeau JH. 2005. Search for testicular cancer gene hits dead-end. Cell Cycle 4(9):1136-8. [PubMed: 16082220]  [MGI Ref ID J:101387]

Noguchi T; Noguchi M. 1985. A recessive mutation (ter) causing germ cell deficiency and a high incidence of congenital testicular teratomas in 129/Sv-ter mice. J Natl Cancer Inst 75(2):385-92. [PubMed: 3860691]  [MGI Ref ID J:7954]

Sakurai T; Iguchi T; Moriwaki K; Noguchi M. 1995. The ter mutation first causes primordial germ cell deficiency in ter/ter mouse embryos at 8 days of gestation. Dev Growth Differ 37(3):293-302.  [MGI Ref ID J:28119]

Youngren KK; Coveney D; Peng X; Bhattacharya C; Schmidt LS; Nickerson ML; Lamb BT; Deng JM; Behringer RR; Capel B; Rubin EM; Nadeau JH; Matin A. 2005. The Ter mutation in the dead end gene causes germ cell loss and testicular germ cell tumours. Nature 435(7040):360-4. [PubMed: 15902260]  [MGI Ref ID J:98580]

Oca2+ related

Mouse Genome Informatics (MGI). 2006. Information obtained from The RIKEN BioResource Center :.  [MGI Ref ID J:104881]

Tyrc-ch related

Anderson PD; Lam MY; Poirier C; Bishop CE; Nadeau JH. 2009. The role of the mouse y chromosome on susceptibility to testicular germ cell tumors. Cancer Res 69(8):3614-8. [PubMed: 19351821]  [MGI Ref ID J:147731]

Beermann F; Ruppert S; Hummler E; Bosch FX; Muller G; Ruther U; Schutz G. 1990. Rescue of the albino phenotype by introduction of a functional tyrosinase gene into mice. EMBO J 9(9):2819-26. [PubMed: 2118105]  [MGI Ref ID J:19279]

Bhattacharya C; Aggarwal S; Zhu R; Kumar M; Zhao M; Meistrich ML; Matin A. 2007. The mouse dead-end gene isoform alpha is necessary for germ cell and embryonic viability. Biochem Biophys Res Commun 355(1):194-9. [PubMed: 17291453]  [MGI Ref ID J:118625]

Dunn LC. 1936. Studies on multiple allelomorphic series in the house mouse. I. Description of agouti and albino series of allelomorphs J Genet 33:443-53.  [MGI Ref ID J:22600]

Errijgers V; Van Dam D; Gantois I; Van Ginneken CJ; Grossman AW; D'Hooge R; De Deyn PP; Kooy RF. 2007. FVB.129P2-Pde6b(+) Tyr(c-ch)/Ant, a sighted variant of the FVB/N mouse strain suitable for behavioral analysis. Genes Brain Behav 6(6):552-7. [PubMed: 17083330]  [MGI Ref ID J:137779]

Feldman HW. 1935. A fifth allelomorph in the albino series of the house mouse J Mammal 16:207-210.  [MGI Ref ID J:83666]

Feldman HW. 1922. A fourth allelomorph in the albino series in mice Am Naturalist 56:573-574.  [MGI Ref ID J:14850]

Klebig ML; Kwon BS; Rinchik EM. 1992. Physical analysis of murine albino deletions that disrupt liver-specific gene regulation or mesoderm development. Mamm Genome 2(1):51-63. [PubMed: 1543902]  [MGI Ref ID J:1540]

Laiosa MD; Lai ZW; Thurmond TS; Fiore NC; DeRossi C; Holdener BC; Gasiewicz TA; Silverstone AE. 2002. 2,3,7,8-tetrachlorodibenzo-p-dioxin causes alterations in lymphocyte development and thymic atrophy in hemopoietic chimeras generated from mice deficient in ARNT2. Toxicol Sci 69(1):117-24. [PubMed: 12215665]  [MGI Ref ID J:113951]

Lamoreux ML; Wakamatsu K; Ito S. 2001. Interaction of major coat color gene functions in mice as studied by chemical analysis of eumelanin and pheomelanin. Pigment Cell Res 14(1):23-31. [PubMed: 11277491]  [MGI Ref ID J:103803]

Lossie AC; Nakamura H; Thomas SE; Justice MJ. 2005. Mutation of l7Rn3 shows that Odz4 is required for mouse gastrulation. Genetics 169(1):285-99. [PubMed: 15489520]  [MGI Ref ID J:96673]

Lyon MF. 1963. Attempts to test the inactive-X theory of dosage compensation in mammals Genet Res 4:93-103.  [MGI Ref ID J:272]

Moyer FH. 1966. Genetic variations in the fine structure and ontogeny of mouse melanin granules. Am Zool 6(1):43-66. [PubMed: 5902512]  [MGI Ref ID J:5001]

RUSSELL ES. 1949. A quantitative histological study of the pigment found in the coat-color mutants of the house mouse; interdependence among the variable granule attributes. Genetics 34(2):133-45. [PubMed: 18117146]  [MGI Ref ID J:148461]

Russell ES. 1948. A Quantitative Histological Study of the Pigment Found in the Coat Color Mutants of the House Mouse. II. Estimates of the Total Volume of Pigment. Genetics 33(3):228-36. [PubMed: 17247280]  [MGI Ref ID J:148462]

Russell ES. 1946. A Quantitative Histological Study of the Pigment Found in the Coat-Color Mutants of the House Mouse. I. Variable Attributes of the Pigment Granules. Genetics 31(3):327-46. [PubMed: 17247200]  [MGI Ref ID J:148463]

Schedl A; Ruppert S; Kelsey G; Thies E; Niswander L; Magnuson T; Klebig ML; Rinchik EM; Schutz G. 1992. Chromosome jumping from flanking markers defines the minimal region for alf/hsdr-1 within the albino-deletion complex. Genomics 14(2):288-97. [PubMed: 1427845]  [MGI Ref ID J:2638]

Silvers WK. 1979. The Coat Colors of Mice; A Model for Mammalian Gene Action and Interaction. In: The Coat Colors of Mice. Springer-Verlag, New York.  [MGI Ref ID J:78801]

Sweet HO. 1987. Acromelanic (c<a>) Mouse News Lett 78:56.  [MGI Ref ID J:14994]

Takeuchi S; Yamamoto H; Takeuchi T. 1988. Expression of tyrosinase gene in mice Genome 30(Suppl 1):260 (Abstr.).  [MGI Ref ID J:30744]

Townsend D; Witkop CJ Jr; Mattson J. 1981. Tyrosinase subcellular distribution and kinetic parameters in wild type and C-locus mutant C57BL/6J mice. J Exp Zool 216(1):113-9. [PubMed: 6793688]  [MGI Ref ID J:6611]

Vasiliou V; Buetler T; Eaton DL; Nebert DW. 2000. Comparison of oxidative stress response parameters in newborn mouse liver versus simian virus 40 (SV40)-transformed hepatocyte cell lines. Biochem Pharmacol 59(6):703-12. [PubMed: 10677587]  [MGI Ref ID J:60274]

Vasiliou V; Reuter SF; Nebert DW. 1997. Extrahepatic expression of NAD(P)H:menadione oxidoreductase, UDP glucuronosyltransferase-1A6, microsomal aldehyde dehydrogenase, and hepatic nuclear factor-1 alpha mRNAs in ch/ch and 14CoS/14CoS mice. Biochem Biophys Res Commun 233(3):631-6. [PubMed: 9168903]  [MGI Ref ID J:40515]

Health & husbandry

Health & Colony Maintenance Information

Currently there no information available for this strain. This may be due to the supply level of this strain.

Purchasing information

Pricing, Supply Level & Notes, Controls, General Terms & Conditions

Pricing

Pricing for USA, Canada and Mexico shipping destinations View International pricing
Price (US dollars $)
Cryorecovery Fee $1900.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Additional Supply Details

Pricing for International shipping destinations View USA Canada and Mexico pricing
Price (US dollars $)
Cryorecovery Fee $2470.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Additional Supply Details

Supply Details

Standard SupplyCryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information.
Supply Notes
  • Cryorecovery - Standard.
    We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. The total number of animals provided, their gender and genotype will vary. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 13 and 16 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
    Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

  • Genomic DNA is available for this strain from the Mouse DNA Resource.

Control Information

  Control
   Untyped from the colony
   002065 129T2/SvEmsJ
 
  Considerations for Choosing Controls
  USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains.
  International - Control Pricing Information for Genetically Engineered Mutant Strains.

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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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