Strain Name:

FL/1Re-KitW/J

Stock Number:

000092

Order this mouse

Availability:

Cryopreserved - Ready for recovery

Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Type Mutant Strain; Spontaneous Mutation;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Specieslaboratory mouse
GenerationN82p
Generation Definitions

Important Note
This strain is homozygous for f.

Description
Flexed tail homozygotes can be identified hematologically as earlyas embryonic day 13 and are detectably paler than normal by embryonic day 16, with most paler than normal by embryonic day 15. Homozygotes are small at birth and have a transitory siderocytic hypochromic anemia due to defective heme synthesis in fetal but not adult reticulocytes. Fetal erythrocytes have more alpha hemoglobin synthesis than beta hemoglobin synthesis. Very high numbers of siderocytes are found at birth and this decreases during the first few weeks of life and stabilizes at approximately 3 weeks of age with 3% siderocytes, significantly higher than in wildtype adults. Most homozygotes have a belly spot and 1 to 5 flexures in the tail due to vertebral fusions. Vertebral fusions are also found elsewhere in the vertebral column. Fewer than expected homozygotes are generated indicating prenatal death and the postnatal death rate is approximately 4 times normal. A small minority of homozygotes have been found to have embryonic neural tube defects or a dorsal enlargement of the head.

Development
The FL/1Re inbred strain, homozygous for f and wildtype for Kit, was made from a female WB/Re heterozygous for KitW bred to a male heterozygous for f from a partially inbred stock derived from crosses between C3H/J and Snell?s WA linkage-testing stock. The integrated FL/1Re congenic strain, segregating for both KitW and f, was derived by repeated backcross-intercross to the developing FL/Re inbred. To generate this FL/1Re segregating congenic a female from the F1 generation of FL/Re heterozygous for KitW and homozygous for f was backcrossed to a WC/Re inbred wildtype for both Kit and f and a Kit wildtype f heterozygous offspring was bred to the F2 generation of the incipient FL/1Re inbred (Russell and McFarland, 1966). This strategy of maintenance, backcrossing KitW carriers to f/f of the FL/1Re homozygous inbred, was maintained for several decades, with this strain reaching generation N58 in 1974, and in 1980 embryos were generated for cryopreservation from +/+ f/f FL/1Re inbred females at generation F79 and KitW/+ f/+ and KitW/+ +/+ congenic males at generation N81.

Control Information

  Control
   Wild-type from the colony
 
  Considerations for Choosing Controls

Related Strains

Other Related Strains
000023   FL/1ReJ
View Other Related Strains     (1 strain)

Strains carrying   KitW allele
000164   B6.Cg-KitW/J
000692   WB/ReJ KitW/J
100410   WBB6F1/J-KitW/KitW-v/J
View Strains carrying   KitW     (3 strains)

Strains carrying   f allele
000023   FL/1ReJ
000259   JE/LeJ
000791   WB.Cg-f/J
View Strains carrying   f     (3 strains)

View Strains carrying other alleles of Kit     (38 strains)

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested.
Gastrointestinal Stromal Tumor; GIST   (KIT)
Mast Cell Disease   (KIT)
Piebald Trait; PBT   (KIT)
Testicular Germ Cell Tumor; TGCT   (KIT)
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

KitW/Kit+

        FL/1Re-KitW/J
  • hematopoietic system phenotype
  • high mean erythrocyte cell number
    • elevated from birth onward   (MGI Ref ID J:24610)
  • increased hematocrit
    • slightly elevated from birth onward   (MGI Ref ID J:24610)

f/f

        FL/1ReJ
  • hematopoietic system phenotype
  • decreased erythrocyte cell number
    • although red cell counts are significantly reduced at birth they achieve near normal levels by 7 days of age   (MGI Ref ID J:24610)
  • decreased hematocrit
    • at birth the hematocrit is significantly lower (31.5 versus 43.4 in controls) but hematocrit reaches normal levles by 7 days of age   (MGI Ref ID J:24610)
  • decreased mean corpuscular volume
    • significantly smaller volumes at birth but normal by 7 days of age   (MGI Ref ID J:24610)
  • impaired hematopoiesis
    • peak numbers of embryonic erythroid colony forming units only about 50% normal numbers in the liver   (MGI Ref ID J:5654)
  • homeostasis/metabolism phenotype
  • abnormal enzyme/coenzyme activity
    • delta aminolaevulinate synthetase activity in embryonic day 16 reticulocytes on a per cell basis is reduced to 53% of that of wild-type controls, and the activity in liver at embryonic day 13-14 is also reduced but to a lesser degree   (MGI Ref ID J:5591)
    • delta aminolaevulinate dehydratase activity in embryonic day 17-18 reticulocytes on a per cell basis is appriximately half of that in wild-type controls   (MGI Ref ID J:5591)
  • growth/size/body phenotype
  • decreased body weight
    • slight reduction in body weight from birth through 60 days of age in both males and females   (MGI Ref ID J:24610)
  • pigmentation phenotype
  • white spotting
    • white pigment covers an average of 22.9% and 23.6% of the ventrum in females and males respectively   (MGI Ref ID J:24610)
  • integument phenotype
  • white spotting
    • white pigment covers an average of 22.9% and 23.6% of the ventrum in females and males respectively   (MGI Ref ID J:24610)

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

KitW/Kit+

        Background Not Specified
  • pigmentation phenotype
  • abnormal coat/hair pigmentation   (MGI Ref ID J:12955)
    • irregular coat pigmentation
      • pigmented areas of the coat may be interspersed with white hairs producing a roan appearance pigmented coat may be interspersed with white hairs creating a roan appearance pigmented areas are interspersed with white hairs producing a roan appearance   (MGI Ref ID J:12955)
    • variable body spotting
      • variable amounts of white spotting   (MGI Ref ID J:12955)
  • hematopoietic system phenotype
  • *normal* hematopoietic system phenotype
    • blood parameters are normal   (MGI Ref ID J:14978)
  • reproductive system phenotype
  • *normal* reproductive system phenotype
    • system is normal   (MGI Ref ID J:14978)
  • integument phenotype
  • abnormal coat/hair pigmentation   (MGI Ref ID J:12955)
    • irregular coat pigmentation
      • pigmented areas of the coat may be interspersed with white hairs producing a roan appearance pigmented coat may be interspersed with white hairs creating a roan appearance pigmented areas are interspersed with white hairs producing a roan appearance   (MGI Ref ID J:12955)
    • variable body spotting
      • variable amounts of white spotting   (MGI Ref ID J:12955)

KitW/KitW

        Background Not Specified
  • mortality/aging
  • complete postnatal lethality
    • death is within the first week of birth   (MGI Ref ID J:12955)
  • hematopoietic system phenotype
  • macrocytic anemia
    • macrocytic anemia begins at 12 days gestation leading to death within the first week of birth   (MGI Ref ID J:14978)
  • pigmentation phenotype
  • abnormal eye pigmentation
    • pigment is restricted to retina   (MGI Ref ID J:12955)
  • absent coat pigmentation
    • white coat color, vividly contrasts with normal black eye color   (MGI Ref ID J:12955)
  • vision/eye phenotype
  • abnormal eye pigmentation
    • pigment is restricted to retina   (MGI Ref ID J:12955)
  • integument phenotype
  • absent coat pigmentation
    • white coat color, vividly contrasts with normal black eye color   (MGI Ref ID J:12955)

f/f

        Background Not Specified
  • mortality/aging
  • partial postnatal lethality
    • death rate in the first 3 to 4 weeks after birth is about 4 times normal   (MGI Ref ID J:12951)
  • limbs/digits/tail phenotype
  • caudal vertebral fusion
    • flexure due to unilateral fusions of successive vertebrae   (MGI Ref ID J:13090)
    • first appears around E14   (MGI Ref ID J:13090)
  • kinked tail
    • 1-5 permanent angles in tail   (MGI Ref ID J:12951)
    • sometimes curves and spirals instead of sharp angles   (MGI Ref ID J:12951)
    • tails can occasionally be nearly normal   (MGI Ref ID J:12951)
  • skeleton phenotype
  • abnormal vertebrae morphology   (MGI Ref ID J:13090)
    • abnormal intervertebral disk development
      • abnormal development   (MGI Ref ID J:13090)
      • fibrous pad sometimes fails to develop or does not develop on one side   (MGI Ref ID J:13090)
    • vertebral fusion
      • fusions seen in caudal vertebrae also seen throughout the vertebral column   (MGI Ref ID J:13090)
      • caudal vertebral fusion
        • flexure due to unilateral fusions of successive vertebrae   (MGI Ref ID J:13090)
        • first appears around E14   (MGI Ref ID J:13090)
  • hematopoietic system phenotype
  • abnormal hematopoiesis
    • delayed maturation of committed erythroid stem cells   (MGI Ref ID J:13598)
    • adults with a poor response to hemopoietic stress   (MGI Ref ID J:13598)
    • anemia   (MGI Ref ID J:12951)
      • anemia at E14 through birth   (MGI Ref ID J:13090)
      • hematopoesis problem in the liver   (MGI Ref ID J:13090)
      • anemia becomes less severe after E16 when hematopoetic function of bone marrow begins   (MGI Ref ID J:13090)
      • recovery from anemia in the first 2 weeks of life   (MGI Ref ID J:13090)
      • hypochromic microcytic anemia
        • transitory hypochromic and microcytic anemia   (MGI Ref ID J:13598)
    • decreased erythrocyte cell number
      • reduced RBC counts from E14 through birth   (MGI Ref ID J:13090)
      • adult RBC counts are normal   (MGI Ref ID J:13090)
  • homeostasis/metabolism phenotype
  • abnormal iron homeostasis
    • defective heme synthesis   (MGI Ref ID J:13598)
  • growth/size/body phenotype
  • abnormal head morphology
    • sometimes there is a dorsal enlargement of the head in front of the ears   (MGI Ref ID J:12951)
  • decreased body size
    • smaller size at birth and through adulthood   (MGI Ref ID J:13090)
  • vision/eye phenotype
  • eyelids fail to open
    • one or both eyes sometimes remain closed   (MGI Ref ID J:12951)
  • pigmentation phenotype
  • belly spot   (MGI Ref ID J:13598)
  • embryogenesis phenotype
  • abnormal neural tube morphology/development
    • a minority of homozygotes assessed during embryonic development are found to have irregular lumen shape, longitudinal waves or angles of the tube, or locally doubled neural tube   (MGI Ref ID J:13090)
  • abnormal notochord morphology
    • a minority of homozygotes assessed during embryonic development are found to have ventral swelling of the notochord, dorsal projections, bifurcate notochord, or other morphological abnormalities in the notochord   (MGI Ref ID J:13090)
  • nervous system phenotype
  • abnormal neural tube morphology/development
    • a minority of homozygotes assessed during embryonic development are found to have irregular lumen shape, longitudinal waves or angles of the tube, or locally doubled neural tube   (MGI Ref ID J:13090)
  • integument phenotype
  • belly spot   (MGI Ref ID J:13598)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

KitW related

Cancer Research
Growth Factors/Receptors/Cytokines
Increased Tumor Incidence
      Gonadal Tumors
      Gonadal Tumors: ovarian
Oncogenes

Dermatology Research
Color and White Spotting Defects

Developmental Biology Research
Neural Crest Defects

Endocrine Deficiency Research
Bone/Bone Marrow Defects
Gonad Defects
Skin Defects

Immunology, Inflammation and Autoimmunity Research
Immunodeficiency
      Mast Cell Deficiency

Neurobiology Research
Hearing Defects
Receptor Defects

Reproductive Biology Research
Developmental Defects Affecting Gonads
      germ cell deficient
Fertility Defects
Gonadal Tumors
      ovarian

Research Tools
Immunology, Inflammation and Autoimmunity Research
      Mast Cell Deficiency

Sensorineural Research
Hearing Defects
Retinal Degeneration

f related

Dermatology Research
Color and White Spotting Defects

Developmental Biology Research
Neural Tube Defects
Skeletal Defects

Hematological Research
Anemia, Iron Deficiency and Transport Defects
      microcytic
Hematopoietic Defects

Neurobiology Research
Neural Tube Defects

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol KitW
Allele Name dominant spotting
Allele Type Spontaneous
Common Name(s) W;
Strain of Originold mutant of the mouse fancy
Gene Symbol and Name Kit, kit oncogene
Chromosome 5
Gene Common Name(s) Bs; C-Kit; CD117; Dominant white spotting; Fdc; Gsfsco1; Gsfsco5; Gsfsow3; PBT; SCFR; SCO1; SCO5; SOW3; Ssm; Steel Factor Receptor; Tr-kit; W; belly-spot; dominant spotting; gsf spotted coat 1; gsf spotted coat 5; phenotype like Sl or W 3; spotted sterile male;
General Note This is an old mutant of the mouse fancy. KitW mutants are a potential model for human inherited pure red cell anemia, called Diamond-Blackfan anemia (OMIM 205900), but mouse mutants do not respond to corticosteroid treatment as do human patients. Thus, the mechanism of anemia causation in the two conditions must be different (J:14286).
Molecular Note A guanosine to adenosine substitution at the first nucleotide at the 5' boundary of the intron following the transmembrane exon results in two different aberrantly spliced transcripts putatively expressed in a tissue specific manner. A deletion of 107 bp was found in transcripts from mast cells of mutant mice. A deletion of 234 was found in transcripts from brain or bone marrow cells. The GT to AT point mutation probably disrupted a splice donor site, thereby causing exon skipping. The 107 bp deletion could have resulted from skipping of a transmembrane region exon and the 234 bp deletion from skipping 3 exons. The 107 bp deletion would generate a stop codon 12 bp downstream because of a frame shift, whereas the larger deletion would still be in frame. Northern blot analysis indicated that mast cells from mutants have only 31-37% of the transcripts as mast cells derived from normal bone marrow, suggesting that the mutation may reduce efficiency and authenticity of transcription and splicing. [MGI Ref ID J:91867]
 
Allele Symbol f
Allele Name flexed tail
Allele Type Spontaneous
Mutation Made By Mark Fleming,   Children's Hospital Boston
Gene Symbol and Name f, flexed-tail
Chromosome 13
General Note

The flexed-tail mutation appeared in a stock maintained by Dr. H.R. Hunt at Michigan State College (J:12951). Homozygotes are small at birth and have a transitory hypochromic, microcytic anemia characterized by a large number of siderocytes containing non-heme iron granules. Most homozygotes also have flexed tail and a belly spot, but these are not constant manifestations of the mutant. Because of the anemia there is probably greater postnatal mortality among f/f than among normal mice (J:14979).

The anemia begins on the 12th day of embryonic life when the liver first starts to produce blood cells (J:14979). It is most intense at 15 days of gestation and still severe at birth, but by 2 weeks of age has disappeared. Although adults have normal blood values, their response to hemopoietic stress is defective (J:5439, J:27511).

The results of numerous studies have led to the conclusion that the prenatal deficiency in number of erythrocytes and the defective response of adult erythropoietic cells are due to a delay in maturation of already committed erythroid stem cells, and that earlier uncommitted precursors are unaffected by f (J:5439, J:5654, J:5582).

An additional effect of f in homozygotes is defective heme synthesis, which occurs in fetal reticulocytes but not in adult reticulocytes nor in erythroblasts at earlier stages of maturation. In fetal reticulocytes there is normal uptake of iron but poor incorporation into hemoglobin (J:5439), probably as a result of reduced activity ofdelta-aminolevulinate synthetase and dehydratase (J:5591).

Fetal erythrocytes of f/f mice have more alpha than beta globin chains. In both f/f and wild-type fetal erythrocytes there is more alpha- than beta-chain mRNA; probably some regulatory mechanism bringing about equal alpha- and beta-chain synthesis exists in wild-type mice but is defective in f/f (J:5827, J:30711).

The tail abnormalities are first noticeable on the 14th day of gestation as abnormal differentiation of the intervertebral discs (J:13090). The possibility that abnormal heme synthesis could cause the tail and pigment defects in f/f mice has been discussed (J:5591).

It was suggested that flexed-tail might be a mutation in the mouse homolog Fancc of the gene defective in human Fanconi anemia, complementation group C, but no mutation in the Fancc gene or abnormalities in Fancc mRNA have been detected in f/f mutants (J:13598). Also, flexed-tail mice are not susceptible to increases in chromosomal aberrations induced by mitomycin C, a characteristic of Fancc mutant mice (J:35839).

This allele arose on a genetically undefined stock in 1927 and was subsequently transferred onto several genetic backgrounds to create the congenic and recombinant inbred lines Je/Le-f/f, FL1/ReJ, WB/ReJ-f/f and C57BL/6J-f/f. The phenotypes listed above might be associated with any of these strains; in most cases it was not specified.

Molecular Note Note that two conflicting reports (J:68377 and J:98445/J:128616) state that the underlying genetic defect in the flexed tail mouse is either in the Sfxn1 or the Smad5 gene. [MGI Ref ID J:128616] [MGI Ref ID J:68377] [MGI Ref ID J:98445]

Genotyping

Genotyping Information


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Russell ES; McFarland EC. 1966. Analysis of pleiotropic effects of W and f genic substitutions in the mouse. Genetics 53(5):949-59. [PubMed: 5929249]  [MGI Ref ID J:24610]

Additional References

KitW related

Agosti V; Corbacioglu S; Ehlers I; Waskow C; Sommer G; Berrozpe G; Kissel H; Tucker CM; Manova K; Moore MA; Rodewald HR; Besmer P. 2004. Critical Role for Kit-mediated Src Kinase But Not PI 3-Kinase Signaling in Pro T and Pro B Cell Development. J Exp Med 199(6):867-78. [PubMed: 15024050]  [MGI Ref ID J:90485]

Akahoshi M; Song CH; Piliponsky AM; Metz M; Guzzetta A; Abrink M; Schlenner SM; Feyerabend TB; Rodewald HR; Pejler G; Tsai M; Galli SJ. 2011. Mast cell chymase reduces the toxicity of Gila monster venom, scorpion venom, and vasoactive intestinal polypeptide in mice. J Clin Invest 121(10):4180-91. [PubMed: 21926462]  [MGI Ref ID J:178494]

Andoh T; Sakai K; Urashima M; Kitazawa K; Honma A; Kuraishi Y. 2012. Involvement of leukotriene B4 in itching in a mouse model of ocular allergy. Exp Eye Res 98:97-103. [PubMed: 22504036]  [MGI Ref ID J:196831]

Aoki H; Hara A; Motohashi T; Kunisada T. 2011. Protective effect of Kit signaling for melanocyte stem cells against radiation-induced genotoxic stress. J Invest Dermatol 131(9):1906-15. [PubMed: 21633369]  [MGI Ref ID J:182201]

Aoki H; Yamada Y; Hara A; Kunisada T. 2009. Two distinct types of mouse melanocyte: differential signaling requirement for the maintenance of non-cutaneous and dermal versus epidermal melanocytes. Development 136(15):2511-21. [PubMed: 19553284]  [MGI Ref ID J:152856]

Aoki R; Kawamura T; Goshima F; Ogawa Y; Nakae S; Nakao A; Moriishi K; Nishiyama Y; Shimada S. 2013. Mast Cells Play a Key Role in Host Defense against Herpes Simplex Virus Infection through TNF-alpha and IL-6 Production. J Invest Dermatol 133(9):2170-9. [PubMed: 23528820]  [MGI Ref ID J:200049]

Arinobu Y; Iwasaki H; Gurish MF; Mizuno S; Shigematsu H; Ozawa H; Tenen DG; Austen KF; Akashi K. 2005. Developmental checkpoints of the basophil/mast cell lineages in adult murine hematopoiesis. Proc Natl Acad Sci U S A 102(50):18105-10. [PubMed: 16330751]  [MGI Ref ID J:104357]

Arnold K; Sarkar A; Yram MA; Polo JM; Bronson R; Sengupta S; Seandel M; Geijsen N; Hochedlinger K. 2011. Sox2(+) adult stem and progenitor cells are important for tissue regeneration and survival of mice. Cell Stem Cell 9(4):317-29. [PubMed: 21982232]  [MGI Ref ID J:177655]

Ayach BB; Yoshimitsu M; Dawood F; Sun M; Arab S; Chen M; Higuchi K; Siatskas C; Lee P; Lim H; Zhang J; Cukerman E; Stanford WL; Medin JA; Liu PP. 2006. Stem cell factor receptor induces progenitor and natural killer cell-mediated cardiac survival and repair after myocardial infarction. Proc Natl Acad Sci U S A 103(7):2304-9. [PubMed: 16467148]  [MGI Ref ID J:106065]

Azuma T; Dojyo M; Ito S; Yamazaki Y; Miyaji H; Ito Y; Suto H; Kuriyama M; Kato T; Kohli Y. 1999. Bile reflux due to disturbed gastric movement is a cause of spontaneous gastric ulcer in W/Wv mice. Dig Dis Sci 44(6):1177-83. [PubMed: 10389693]  [MGI Ref ID J:57206]

Baumann U; Chouchakova N; Gewecke B; Kohl J; Carroll MC; Schmidt RE; Gessner JE. 2001. Distinct tissue site-specific requirements of mast cells and complement components C3/C5a receptor in IgG immune complex-induced injury of skin and lung. J Immunol 167(2):1022-7. [PubMed: 11441111]  [MGI Ref ID J:120524]

Beckett EA; Ro S; Bayguinov Y; Sanders KM; Ward SM. 2007. Kit signaling is essential for development and maintenance of interstitial cells of Cajal and electrical rhythmicity in the embryonic gastrointestinal tract. Dev Dyn 236(1):60-72. [PubMed: 16937373]  [MGI Ref ID J:116633]

Bennett JL; Blanchet MR; Zhao L; Zbytnuik L; Antignano F; Gold M; Kubes P; McNagny KM. 2009. Bone marrow-derived mast cells accumulate in the central nervous system during inflammation but are dispensable for experimental autoimmune encephalomyelitis pathogenesis. J Immunol 182(9):5507-14. [PubMed: 19380799]  [MGI Ref ID J:147712]

Bernstein SE. 1969. Hereditary disorders of the rodent erythron. In: Genetics in Laboratory Animal Medicine. Natl Acad Sci Publ, Washington, DC.  [MGI Ref ID J:30699]

Biedermann T; Kneilling M; Mailhammer R; Maier K; Sander CA; Kollias G; Kunkel SL; Hultner L; Rocken M. 2000. Mast cells control neutrophil recruitment during T cell-mediated delayed-type hypersensitivity reactions through tumor necrosis factor and macrophage inflammatory protein 2 J Exp Med 192(10):1441-52. [PubMed: 11085746]  [MGI Ref ID J:65843]

Blanchet MR; Gold M; Maltby S; Bennett J; Petri B; Kubes P; Lee DM; McNagny KM. 2010. Loss of CD34 leads to exacerbated autoimmune arthritis through increased vascular permeability. J Immunol 184(3):1292-9. [PubMed: 20038636]  [MGI Ref ID J:159534]

Bosch-Marce M; Okuyama H; Wesley JB; Sarkar K; Kimura H; Liu YV; Zhang H; Strazza M; Rey S; Savino L; Zhou YF; McDonald KR; Na Y; Vandiver S; Rabi A; Shaked Y; Kerbel R; Lavallee T; Semenza GL. 2007. Effects of aging and hypoxia-inducible factor-1 activity on angiogenic cell mobilization and recovery of perfusion after limb ischemia. Circ Res 101(12):1310-8. [PubMed: 17932327]  [MGI Ref ID J:142789]

Burke JM; Ganley-Leal LM; Khatri A; Wetzler LM. 2007. Neisseria meningitidis PorB, a TLR2 ligand, induces an antigen-specific eosinophil recall response: potential adjuvant for helminth vaccines? J Immunol 179(5):3222-30. [PubMed: 17709538]  [MGI Ref ID J:151825]

Campagnolo L; Moscatelli I; Pellegrini M; Siracusa G; Stuhlmann H. 2008. Expression of EGFL7 in primordial germ cells and in adult ovaries and testes. Gene Expr Patterns 8(6):389-96. [PubMed: 18556249]  [MGI Ref ID J:137617]

Cara DC; Ebbert KV; McCafferty DM. 2004. Mast cell-independent mechanisms of immediate hypersensitivity: a role for platelets. J Immunol 172(8):4964-71. [PubMed: 15067077]  [MGI Ref ID J:89115]

Chakraborty P; William Buaas F; Sharma M; Smith BE; Greenlee AR; Eacker SM; Braun RE. 2014. Androgen-dependent sertoli cell tight junction remodeling is mediated by multiple tight junction components. Mol Endocrinol 28(7):1055-72. [PubMed: 24825397]  [MGI Ref ID J:210656]

Chappaz S; Gartner C; Rodewald HR; Finke D. 2010. Kit ligand and Il7 differentially regulate Peyer's patch and lymph node development. J Immunol 185(6):3514-9. [PubMed: 20709954]  [MGI Ref ID J:163826]

Chen L; Faire M; Kissner MD; Laird DJ. 2013. Primordial germ cells and gastrointestinal stromal tumors respond distinctly to a cKit overactivating allele. Hum Mol Genet 22(2):313-27. [PubMed: 23077213]  [MGI Ref ID J:191131]

Chen R; Ning G; Zhao ML; Fleming MG; Diaz LA; Werb Z; Liu Z. 2001. Mast cells play a key role in neutrophil recruitment in experimental bullous pemphigoid. J Clin Invest 108(8):1151-8. [PubMed: 11602622]  [MGI Ref ID J:72195]

Chen X; Feng BS; Zheng PY; Liao XQ; Chong J; Tang SG; Yang PC. 2008. Fc gamma receptor signaling in mast cells links microbial stimulation to mucosal immune inflammation in the intestine. Am J Pathol 173(6):1647-56. [PubMed: 18974296]  [MGI Ref ID J:143927]

Cheng M; Zhou J; Wu M; Boriboun C; Thorne T; Liu T; Xiang Z; Zeng Q; Tanaka T; Tang YL; Kishore R; Tomasson MH; Miller RJ; Losordo DW; Qin G. 2010. CXCR4-mediated bone marrow progenitor cell maintenance and mobilization are modulated by c-kit activity. Circ Res 107(9):1083-93. [PubMed: 20847314]  [MGI Ref ID J:178186]

Chikahisa S; Kodama T; Soya A; Sagawa Y; Ishimaru Y; Sei H; Nishino S. 2013. Histamine from brain resident MAST cells promotes wakefulness and modulates behavioral states. PLoS One 8(10):e78434. [PubMed: 24205232]  [MGI Ref ID J:209229]

Choi E; Han C; Park I; Lee B; Jin S; Choi H; Kim do H; Park ZY; Eddy EM; Cho C. 2008. A novel germ cell-specific protein, SHIP1, forms a complex with chromatin remodeling activity during spermatogenesis. J Biol Chem 283(50):35283-94. [PubMed: 18849567]  [MGI Ref ID J:144592]

Choi IH; Shin YM; Park JS; Lee MS; Han EH; Chai OH; Im SY; Ha TY; Lee HK. 1998. Immunoglobulin E-dependent active fatal anaphylaxis in mast cell-deficient mice. J Exp Med 188(9):1587-92. [PubMed: 9802970]  [MGI Ref ID J:50773]

Cimini M; Fazel S; Zhuo S; Xaymardan M; Fujii H; Weisel RD; Li RK. 2007. c-kit dysfunction impairs myocardial healing after infarction. Circulation 116(11 Suppl):I77-82. [PubMed: 17846329]  [MGI Ref ID J:139839]

Clark EA; Shultz LD; Pollack SB. 1981. Mutations in mice that influence natural killer (NK) cell activity. Immunogenetics 12(5-6):601-13. [PubMed: 6971254]  [MGI Ref ID J:6485]

Cohn L; Homer RJ; MacLeod H; Mohrs M; Brombacher F; Bottomly K. 1999. Th2-induced airway mucus production is dependent on IL-4Ralpha, but not on eosinophils. J Immunol 162(10):6178-83. [PubMed: 10229862]  [MGI Ref ID J:119786]

Colucci F; Di Santo JP. 2000. The receptor tyrosine kinase c-kit provides a critical signal for survival, expansion, and maturation of mouse natural killer cells. Blood 95(3):984-91. [PubMed: 10648413]  [MGI Ref ID J:59898]

Corr M; Crain B. 2002. The role of FcgammaR signaling in the K/B x N serum transfer model of arthritis. J Immunol 169(11):6604-9. [PubMed: 12444173]  [MGI Ref ID J:124384]

Crosby JR; Cieslewicz G; Borchers M; Hines E; Carrigan P; Lee JJ; Lee NA. 2002. Early phase bronchoconstriction in the mouse requires allergen-specific IgG. J Immunol 168(8):4050-4. [PubMed: 11937563]  [MGI Ref ID J:125656]

D'Andrea MR; Saban MR; Gerard NP; Wershil BK; Saban R. 2005. Lack of neurokinin-1 receptor expression affects tissue mast cell numbers but not their spatial relationship with nerves. Am J Physiol Regul Integr Comp Physiol 288(2):R491-500. [PubMed: 15458971]  [MGI Ref ID J:95761]

Dastych J; Taub D; Hardison MC; Metcalfe DD. 1998. Tyrosine kinase-deficient Wv c-kit induces mast cell adhesion and chemotaxis. Am J Physiol 275(5 Pt 1):C1291-9. [PubMed: 9814978]  [MGI Ref ID J:50928]

Depinay N; Hacini F; Beghdadi W; Peronet R; Mecheri S. 2006. Mast cell-dependent down-regulation of antigen-specific immune responses by mosquito bites. J Immunol 176(7):4141-6. [PubMed: 16547250]  [MGI Ref ID J:129876]

Dietz JA; Li Y; Chung LM; Yandell BS; Schlamp CL; Nickells RW. 2008. Rgcs1, a dominant QTL that affects retinal ganglion cell death after optic nerve crush in mice. BMC Neurosci 9:74. [PubMed: 18671875]  [MGI Ref ID J:142950]

Diwakar G; Zhang D; Jiang S; Hornyak TJ. 2008. Neurofibromin as a regulator of melanocyte development and differentiation. J Cell Sci 121(Pt 2):167-77. [PubMed: 18089649]  [MGI Ref ID J:130856]

Dombrowicz D; Flamand V; Miyajima I; Ravetch JV; Galli SJ; Kinet JP. 1997. Absence of Fc epsilonRI alpha chain results in upregulation of Fc gammaRIII-dependent mast cell degranulation and anaphylaxis. Evidence of competition between Fc epsilonRI and Fc gammaRIII for limiting amounts of FcR beta and gamma chains. J Clin Invest 99(5):915-25. [PubMed: 9062349]  [MGI Ref ID J:78651]

Dunford PJ; O'Donnell N; Riley JP; Williams KN; Karlsson L; Thurmond RL. 2006. The histamine H4 receptor mediates allergic airway inflammation by regulating the activation of CD4+ T cells. J Immunol 176(11):7062-70. [PubMed: 16709868]  [MGI Ref ID J:131785]

Dunford PJ; Williams KN; Desai PJ; Karlsson L; McQueen D; Thurmond RL. 2007. Histamine H4 receptor antagonists are superior to traditional antihistamines in the attenuation of experimental pruritus. J Allergy Clin Immunol 119(1):176-83. [PubMed: 17208599]  [MGI Ref ID J:169999]

Dunn LC. 1937. Studies on Spotting Patterns II. Genetic Analysis of Variegated Spotting in the House Mouse. Genetics 22(1):43-64. [PubMed: 17246829]  [MGI Ref ID J:12955]

Edelson BT; Li Z; Pappan LK; Zutter MM. 2004. Mast cell-mediated inflammatory responses require the alpha 2 beta 1 integrin. Blood 103(6):2214-20. [PubMed: 14645004]  [MGI Ref ID J:88567]

Eller K; Wolf D; Huber JM; Metz M; Mayer G; McKenzie AN; Maurer M; Rosenkranz AR; Wolf AM. 2011. IL-9 production by regulatory T cells recruits mast cells that are essential for regulatory T cell-induced immune suppression. J Immunol 186(1):83-91. [PubMed: 21115728]  [MGI Ref ID J:168723]

Everett ET; Pablos JL; Harley RA; LeRoy EC; Norris JS. 1995. The role of mast cells in the development of skin fibrosis in tight-skin mutant mice. Comp Biochem Physiol A Physiol 110(2):159-65. [PubMed: 7704626]  [MGI Ref ID J:24076]

Fazel S; Cimini M; Chen L; Li S; Angoulvant D; Fedak P; Verma S; Weisel RD; Keating A; Li RK. 2006. Cardioprotective c-kit+ cells are from the bone marrow and regulate the myocardial balance of angiogenic cytokines. J Clin Invest 116(7):1865-77. [PubMed: 16823487]  [MGI Ref ID J:111717]

Feng BS; He SH; Zheng PY; Wu L; Yang PC. 2007. Mast cells play a crucial role in Staphylococcus aureus peptidoglycan-induced diarrhea. Am J Pathol 171(2):537-47. [PubMed: 17600127]  [MGI Ref ID J:123928]

Feng ZC; Donnelly L; Li J; Krishnamurthy M; Riopel M; Wang R. 2012. Inhibition of Gsk3beta activity improves beta-cell function in c-Kit(Wv/+) male mice. Lab Invest 92(4):543-55. [PubMed: 22249311]  [MGI Ref ID J:181933]

Fewkes NM; Krauss AC; Guimond M; Meadors JL; Dobre S; Mackall CL. 2010. Pharmacologic modulation of niche accessibility via tyrosine kinase inhibition enhances marrow and thymic engraftment after hematopoietic stem cell transplantation. Blood 115(20):4120-9. [PubMed: 20231424]  [MGI Ref ID J:160231]

Feyerabend TB; Weiser A; Tietz A; Stassen M; Harris N; Kopf M; Radermacher P; Moller P; Benoist C; Mathis D; Fehling HJ; Rodewald HR. 2011. Cre-Mediated Cell Ablation Contests Mast Cell Contribution in Models of Antibody- and T Cell-Mediated Autoimmunity. Immunity :. [PubMed: 22101159]  [MGI Ref ID J:178942]

Finkelman FD; Morris SC; Orekhova T; Mori M; Donaldson D; Reiner SL; Reilly NL; Schopf L; Urban JF Jr. 2000. Stat6 regulation of in vivo IL-4 responses. J Immunol 164(5):2303-10. [PubMed: 10679064]  [MGI Ref ID J:112038]

Forrest AS; Hennig GW; Jokela-Willis S; Park CD; Sanders KM. 2009. Prostaglandin regulation of gastric slow waves and peristalsis. Am J Physiol Gastrointest Liver Physiol 296(6):G1180-90. [PubMed: 19359421]  [MGI Ref ID J:149682]

Fujimura T; Furukawa H; Doi Y; Makishima K; Fujimoto S. 1999. Immunoreactivity of endothelins and endothelin receptor in the stria vascularis of the mouse cochlea. Hear Res 128(1-2):135-46. [PubMed: 10082294]  [MGI Ref ID J:108904]

Fujimura T; Suzuki H; Shimizu T; Tokui N; Kitamura T; Udaka T; Doi Y. 2005. Pathological alterations of strial capillaries in dominant white spotting W/Wv mice. Hear Res 209(1-2):53-9. [PubMed: 16054310]  [MGI Ref ID J:102420]

Furusawa J; Moro K; Motomura Y; Okamoto K; Zhu J; Takayanagi H; Kubo M; Koyasu S. 2013. Critical role of p38 and GATA3 in natural helper cell function. J Immunol 191(4):1818-26. [PubMed: 23851685]  [MGI Ref ID J:205695]

Furuta T; Kikuchi T; Iwakura Y; Watanabe N. 2006. Protective roles of mast cells and mast cell-derived TNF in murine malaria. J Immunol 177(5):3294-302. [PubMed: 16920970]  [MGI Ref ID J:139538]

Geissler EN; McFarland EC; Russell ES. 1981. Analysis of pleiotropism at the dominant white-spotting (W) locus of the house mouse: a description of ten new W alleles. Genetics 97(2):337-61. [PubMed: 7274658]  [MGI Ref ID J:6571]

Goldman DC; Berg LK; Heinrich MC; Christian JL. 2006. Ectodermally derived steel/stem cell factor functions non-cell autonomously during primitive erythropoiesis in Xenopus. Blood 107(8):3114-21. [PubMed: 16357321]  [MGI Ref ID J:131233]

Gore BB; Wong KG; Tessier-Lavigne M. 2008. Stem cell factor functions as an outgrowth-promoting factor to enable axon exit from the midline intermediate target. Neuron 57(4):501-10. [PubMed: 18304480]  [MGI Ref ID J:132880]

Grimbaldeston MA; Nakae S; Kalesnikoff J; Tsai M; Galli SJ. 2007. Mast cell-derived interleukin 10 limits skin pathology in contact dermatitis and chronic irradiation with ultraviolet B. Nat Immunol 8(10):1095-104. [PubMed: 17767162]  [MGI Ref ID J:125267]

Gruneberg H. 1942. Inherited macrocytic anaemias in the house mouse. II. Dominance relationships J Genet 43:285-93.  [MGI Ref ID J:14978]

Gurish MF; Tao H; Abonia JP; Arya A; Friend DS; Parker CM; Austen KF. 2001. Intestinal mast cell progenitors require CD49dbeta7 (alpha4beta7 integrin) for tissue-specific homing. J Exp Med 194(9):1243-52. [PubMed: 11696590]  [MGI Ref ID J:119138]

Hasegawa H; Noguchi J; Yamashita M; Okada R; Sugimoto R; Furuya M; Unoki T; Funakoshi Y; Baba T; Kanaho Y. 2012. Phosphatidylinositol 4-phosphate 5-kinase is indispensable for mouse spermatogenesis. Biol Reprod 86(5):136, 1-12. [PubMed: 22321832]  [MGI Ref ID J:185835]

Hayashi S; Kunisada T; Ogawa M; Yamaguchi K; Nishikawa S. 1991. Exon skipping by mutation of an authentic splice site of c-kit gene in W/W mouse. Nucleic Acids Res 19(6):1267-71. [PubMed: 1709486]  [MGI Ref ID J:91867]

Hayashi T; Cottam HB; Chan M; Jin G; Tawatao RI; Crain B; Ronacher L; Messer K; Carson DA; Corr M. 2008. Mast cell-dependent anorexia and hypothermia induced by mucosal activation of Toll-like receptor 7. Am J Physiol Regul Integr Comp Physiol 295(1):R123-32. [PubMed: 18480244]  [MGI Ref ID J:148644]

Heimbach L; Li Z; Berkowitz P; Zhao M; Li N; Rubenstein DS; Diaz LA; Liu Z. 2011. The C5a Receptor on Mast Cells Is Critical for the Autoimmune Skin-blistering Disease Bullous Pemphigoid. J Biol Chem 286(17):15003-9. [PubMed: 21393236]  [MGI Ref ID J:172081]

Hepworth MR; Danilowicz-Luebert E; Rausch S; Metz M; Klotz C; Maurer M; Hartmann S. 2012. Mast cells orchestrate type 2 immunity to helminths through regulation of tissue-derived cytokines. Proc Natl Acad Sci U S A 109(17):6644-9. [PubMed: 22493240]  [MGI Ref ID J:183844]

Higuchi H; Hara M; Yamamoto K; Miyamoto T; Kinoshita M; Yamada T; Uchiyama K; Matsumori A. 2008. Mast cells play a critical role in the pathogenesis of viral myocarditis. Circulation 118(4):363-72. [PubMed: 18606918]  [MGI Ref ID J:155664]

Hochegger K; Siebenhaar F; Vielhauer V; Heininger D; Mayadas TN; Mayer G; Maurer M; Rosenkranz AR. 2005. Role of mast cells in experimental anti-glomerular basement membrane glomerulonephritis. Eur J Immunol 35(10):3074-82. [PubMed: 16180252]  [MGI Ref ID J:113500]

Horiguchi S; Horiguchi K; Nojyo Y; Iino S. 2010. Downregulation of msh-like 2 (msx2) and neurotrophic tyrosine kinase receptor type 2 (ntrk2) in the developmental gut of KIT mutant mice. Biochem Biophys Res Commun 396(3):774-9. [PubMed: 20460112]  [MGI Ref ID J:162252]

Huizinga JD; Liu LW; Fitzpatrick A; White E; Gill S; Wang XY; Zarate N; Krebs L; Choi C; Starret T; Dixit D; Ye J. 2008. Deficiency of intramuscular ICC increases fundic muscle excitability but does not impede nitrergic innervation. Am J Physiol Gastrointest Liver Physiol 294(2):G589-94. [PubMed: 18096611]  [MGI Ref ID J:132366]

Huizinga JD; Thuneberg L; Kluppel M; Malysz J; Mikkelsen HB; Bernstein A. 1995. W/kit gene required for interstitial cells of Cajal and for intestinal pacemaker activity. Nature 373(6512):347-9. [PubMed: 7530333]  [MGI Ref ID J:22674]

Ierna MX; Scales HE; Saunders KL; Lawrence CE. 2008. Mast cell production of IL-4 and TNF may be required for protective and pathological responses in gastrointestinal helminth infection. Mucosal Immunol 1(2):147-55. [PubMed: 19079172]  [MGI Ref ID J:191926]

Iino S; Horiguchi S; Horiguchi K; Nojyo Y. 2007. Interstitial cells of Cajal in the gastrointestinal musculature of W mutant mice. Arch Histol Cytol 70(3):163-73. [PubMed: 18079585]  [MGI Ref ID J:143817]

Ito A; Jippo T; Wakayama T; Morii E; Koma Y; Onda H; Nojima H; Iseki S; Kitamura Y. 2003. SgIGSF: a new mast-cell adhesion molecule used for attachment to fibroblasts and transcriptionally regulated by MITF. Blood 101(7):2601-8. [PubMed: 12456501]  [MGI Ref ID J:115530]

Iyer AS; August A. 2008. The Tec family kinase, IL-2-inducible T cell kinase, differentially controls mast cell responses. J Immunol 180(12):7869-77. [PubMed: 18523250]  [MGI Ref ID J:137249]

Jawdat DM; Rowden G; Marshall JS. 2006. Mast cells have a pivotal role in TNF-independent lymph node hypertrophy and the mobilization of Langerhans cells in response to bacterial peptidoglycan. J Immunol 177(3):1755-62. [PubMed: 16849485]  [MGI Ref ID J:137976]

Jiang Y; Bhargava V; Mittal RK. 2009. Mechanism of stretch-activated excitatory and inhibitory responses in the lower esophageal sphincter. Am J Physiol Gastrointest Liver Physiol 297(2):G397-405. [PubMed: 19520741]  [MGI Ref ID J:151528]

Johnson D; Yasui D; Seeldrayers P. 1991. An analysis of mast cell frequency in the rodent nervous system: numbers vary between different strains and can be reconstituted in mast cell-deficient mice. J Neuropathol Exp Neurol 50(3):227-34. [PubMed: 2022965]  [MGI Ref ID J:121259]

Jones TG; Hallgren J; Humbles A; Burwell T; Finkelman FD; Alcaide P; Austen KF; Gurish MF. 2009. Antigen-induced increases in pulmonary mast cell progenitor numbers depend on IL-9 and CD1d-restricted NKT cells. J Immunol 183(8):5251-60. [PubMed: 19783672]  [MGI Ref ID J:153832]

Kanamaru Y; Scandiuzzi L; Essig M; Brochetta C; Guerin-Marchand C; Tomino Y; Monteiro RC; Peuchmaur M; Blank U. 2006. Mast cell-mediated remodeling and fibrinolytic activity protect against fatal glomerulonephritis. J Immunol 176(9):5607-15. [PubMed: 16622030]  [MGI Ref ID J:131649]

Kanatsu-Shinohara M; Inoue K; Miki H; Ogonuki N; Takehashi M; Morimoto T; Ogura A; Shinohara T. 2006. Clonal origin of germ cell colonies after spermatogonial transplantation in mice. Biol Reprod 75(1):68-74. [PubMed: 16598026]  [MGI Ref ID J:111774]

Kandere-Grzybowska K; Gheorghe D; Priller J; Esposito P; Huang M; Gerard N; Theoharides TC. 2003. Stress-induced dura vascular permeability does not develop in mast cell-deficient and neurokinin-1 receptor knockout mice. Brain Res 980(2):213-20. [PubMed: 12867261]  [MGI Ref ID J:84660]

Kanjarawi R; Dy M; Bardel E; Sparwasser T; Dubois B; Mecheri S; Kaiserlian D. 2013. Regulatory CD4+Foxp3+ T cells control the severity of anaphylaxis. PLoS One 8(7):e69183. [PubMed: 23922690]  [MGI Ref ID J:203276]

Karlsen TV; Bletsa A; Gjerde EA; Reed RK. 2007. Lowering of interstitial fluid pressure after neurogenic inflammation in mouse skin is partly dependent on mast cells. Am J Physiol Heart Circ Physiol 292(4):H1821-7. [PubMed: 17158654]  [MGI Ref ID J:125823]

Ketavarapu JM; Rodriguez AR; Yu JJ; Cong Y; Murthy AK; Forsthuber TG; Guentzel MN; Klose KE; Berton MT; Arulanandam BP. 2008. Mast cells inhibit intramacrophage Francisella tularensis replication via contact and secreted products including IL-4. Proc Natl Acad Sci U S A 105(27):9313-8. [PubMed: 18591675]  [MGI Ref ID J:138191]

Kim YS; Ko HM; Kang NI; Song CH; Zhang X; Chung WC; Kim JH; Choi IH; Park YM; Kim GY; Im SY; Lee HK. 2007. Mast cells play a key role in the development of late airway hyperresponsiveness through TNF-alpha in a murine model of asthma. Eur J Immunol 37(4):1107-15. [PubMed: 17372990]  [MGI Ref ID J:120842]

Kimura T; Sugaya M; Blauvelt A; Okochi H; Sato S. 2013. Delayed wound healing due to increased interleukin-10 expression in mice with lymphatic dysfunction. J Leukoc Biol 94(1):137-45. [PubMed: 23650621]  [MGI Ref ID J:201849]

Kimura Y; Ding B; Imai N; Nolan DJ; Butler JM; Rafii S. 2011. c-Kit-Mediated Functional Positioning of Stem Cells to Their Niches Is Essential for Maintenance and Regeneration of Adult Hematopoiesis. PLoS One 6(10):e26918. [PubMed: 22046410]  [MGI Ref ID J:178071]

Kitamura Y; Go S. 1979. Decreased production of mast cells in S1/S1d anemic mice. Blood 53(3):492-7. [PubMed: 367470]  [MGI Ref ID J:6084]

Kitamura Y; Yokoyama M; Matsuda H; Shimada M. 1980. Coincidental development of forestomach papilloma and prepyloric ulcer in nontreated mutant mice of W/Wv and SI/SId genotypes. Cancer Res 40(9):3392-7. [PubMed: 7000343]  [MGI Ref ID J:6393]

Kobayashi T; Miura T; Haba T; Sato M; Serizawa I; Nagai H; Ishizaka K. 2000. An essential role of mast cells in the development of airway hyperresponsiveness in a murine asthma model. J Immunol 164(7):3855-61. [PubMed: 10725747]  [MGI Ref ID J:61405]

Kolaczkowska E; Seljelid R; Plytycz B. 2001. Role of mast cells in zymosan-induced peritoneal inflammation in Balb/c and mast cell-deficient WBB6F1 mice. J Leukoc Biol 69(1):33-42. [PubMed: 11200065]  [MGI Ref ID J:66995]

Kraft S; Jouvin MH; Kulkarni N; Kissing S; Morgan ES; Dvorak AM; Schroder B; Saftig P; Kinet JP. 2013. The tetraspanin CD63 is required for efficient IgE-mediated mast cell degranulation and anaphylaxis. J Immunol 191(6):2871-8. [PubMed: 23945142]  [MGI Ref ID J:205899]

Krishnamoorthy N; Oriss TB; Paglia M; Fei M; Yarlagadda M; Vanhaesebroeck B; Ray A; Ray P. 2008. Activation of c-Kit in dendritic cells regulates T helper cell differentiation and allergic asthma. Nat Med 14(5):565-73. [PubMed: 18454155]  [MGI Ref ID J:136704]

Kung TT; Stelts D; Zurcher JA; Jones H; Umland SP; Kreutner W; Egan RW; Chapman RW. 1995. Mast cells modulate allergic pulmonary eosinophilia in mice. Am J Respir Cell Mol Biol 12(4):404-9. [PubMed: 7695919]  [MGI Ref ID J:25736]

Lantz CS; Boesiger J; Song CH; Mach N; Kobayashi T; Mulligan RC; Nawa Y; Dranoff G; Galli SJ. 1998. Role for interleukin-3 in mast-cell and basophil development and in immunity to parasites. Nature 392(6671):90-3. [PubMed: 9510253]  [MGI Ref ID J:80500]

Lawrence CE; Paterson YY; Wright SH; Knight PA; Miller HR. 2004. Mouse mast cell protease-1 is required for the enteropathy induced by gastrointestinal helminth infection in the mouse. Gastroenterology 127(1):155-65. [PubMed: 15236182]  [MGI Ref ID J:93616]

Lee DM; Friend DS; Gurish MF; Benoist C; Mathis D; Brenner MB. 2002. Mast cells: a cellular link between autoantibodies and inflammatory arthritis. Science 297(5587):1689-92. [PubMed: 12215644]  [MGI Ref ID J:78906]

Leong KG; Wang BE; Johnson L; Gao WQ. 2008. Generation of a prostate from a single adult stem cell. Nature 456(7223):804-8. [PubMed: 18946470]  [MGI Ref ID J:143788]

Levin MD; Lu MM; Petrenko NB; Hawkins BJ; Gupta TH; Lang D; Buckley PT; Jochems J; Liu F; Spurney CF; Yuan LJ; Jacobson JT; Brown CB; Huang L; Beermann F; Margulies KB; Madesh M; Eberwine JH; Epstein JA; Patel VV. 2009. Melanocyte-like cells in the heart and pulmonary veins contribute to atrial arrhythmia triggers. J Clin Invest 119(11):3420-36. [PubMed: 19855129]  [MGI Ref ID J:154593]

Li E; Zhou P; Petrin Z; Singer SM. 2004. Mast cell-dependent control of Giardia lamblia infections in mice. Infect Immun 72(11):6642-9. [PubMed: 15501797]  [MGI Ref ID J:93272]

Li M; Liu K; Michalicek J; Angus JA; Hunt JE; Dell'Italia LJ; Feneley MP; Graham RM; Husain A. 2004. Involvement of chymase-mediated angiotensin II generation in blood pressure regulation. J Clin Invest 114(1):112-20. [PubMed: 15232618]  [MGI Ref ID J:91374]

Li M; Naqvi N; Yahiro E; Liu K; Powell PC; Bradley WE; Martin DI; Graham RM; Dell'Italia LJ; Husain A. 2008. c-kit is required for cardiomyocyte terminal differentiation. Circ Res 102(6):677-85. [PubMed: 18258857]  [MGI Ref ID J:147651]

Liu J; Divoux A; Sun J; Zhang J; Clement K; Glickman JN; Sukhova GK; Wolters PJ; Du J; Gorgun CZ; Doria A; Libby P; Blumberg RS; Kahn BB; Hotamisligil GS; Shi GP. 2009. Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice. Nat Med 15(8):940-5. [PubMed: 19633655]  [MGI Ref ID J:152187]

Lo Celso C; Fleming HE; Wu JW; Zhao CX; Miake-Lye S; Fujisaki J; Cote D; Rowe DW; Lin CP; Scadden DT. 2009. Live-animal tracking of individual haematopoietic stem/progenitor cells in their niche. Nature 457(7225):92-6. [PubMed: 19052546]  [MGI Ref ID J:143898]

Lourenssen S; Motro B; Bernstein A; Diamond J. 2000. Defects in sensory nerve numbers and growth in mutant Kit and Steel mice. Neuroreport 11(6):1159-65. [PubMed: 10817584]  [MGI Ref ID J:103680]

Maatouk DM; Mork L; Hinson A; Kobayashi A; McMahon AP; Capel B. 2012. Germ cells are not required to establish the female pathway in mouse fetal gonads. PLoS One 7(10):e47238. [PubMed: 23091613]  [MGI Ref ID J:192186]

Mackarehtschian K; Hardin JD; Moore KA; Boast S; Goff SP; Lemischka IR. 1995. Targeted disruption of the flk2/flt3 gene leads to deficiencies in primitive hematopoietic progenitors. Immunity 3(1):147-61. [PubMed: 7621074]  [MGI Ref ID J:27238]

Mackins CJ; Kano S; Seyedi N; Schafer U; Reid AC; Machida T; Silver RB; Levi R. 2006. Cardiac mast cell-derived renin promotes local angiotensin formation, norepinephrine release, and arrhythmias in ischemia/reperfusion. J Clin Invest 116(4):1063-70. [PubMed: 16585966]  [MGI Ref ID J:107810]

Madden KB; Whitman L; Sullivan C; Gause WC; Urban JF Jr; Katona IM; Finkelman FD; Shea-Donohue T. 2002. Role of STAT6 and mast cells in IL-4- and IL-13-induced alterations in murine intestinal epithelial cell function. J Immunol 169(8):4417-22. [PubMed: 12370375]  [MGI Ref ID J:120045]

Magnol L; Chevallier MC; Nalesso V; Retif S; Fuchs H; Klempt M; Pereira P; Riottot M; Andrzejewski S; Doan BT; Panthier JJ; Puech A; Beloeil JC; de Angelis MH; Herault Y. 2007. KIT is required for hepatic function during mouse post-natal development. BMC Dev Biol 7:81. [PubMed: 17612398]  [MGI Ref ID J:125831]

Majumdar MK; Everett ET; Xiao X; Cooper R; Langley K; Kapur R; Vik T; Williams DA. 1996. Xenogeneic expression of human stem cell factor in transgenic mice mimics codominant c-kit mutations. Blood 87(8):3203-11. [PubMed: 8605335]  [MGI Ref ID J:32600]

Malaviya R; Navara C; Uckun FM. 2001. Role of Janus kinase 3 in mast cell-mediated innate immunity against gram-negative bacteria. Immunity 15(2):313-21. [PubMed: 11520465]  [MGI Ref ID J:111537]

Martins VC; Busch K; Juraeva D; Blum C; Ludwig C; Rasche V; Lasitschka F; Mastitsky SE; Brors B; Hielscher T; Fehling HJ; Rodewald HR. 2014. Cell competition is a tumour suppressor mechanism in the thymus. Nature 509(7501):465-70. [PubMed: 24828041]  [MGI Ref ID J:210588]

Martins VC; Ruggiero E; Schlenner SM; Madan V; Schmidt M; Fink PJ; von Kalle C; Rodewald HR. 2012. Thymus-autonomous T cell development in the absence of progenitor import. J Exp Med 209(8):1409-17. [PubMed: 22778389]  [MGI Ref ID J:189166]

Maurer M; Lopez Kostka S; Siebenhaar F; Moelle K; Metz M; Knop J; von Stebut E. 2006. Skin mast cells control T cell-dependent host defense in Leishmania major infections. FASEB J 20(14):2460-7. [PubMed: 17142795]  [MGI Ref ID J:146704]

Maurer M; Seidel-Guyenot W; Metz M; Knop J; Steinbrink K. 2003. Critical role of IL-10 in the induction of low zone tolerance to contact allergens. J Clin Invest 112(3):432-9. [PubMed: 12865418]  [MGI Ref ID J:118509]

Maurer M; Wedemeyer J; Metz M; Piliponsky AM; Weller K; Chatterjea D; Clouthier DE; Yanagisawa MM; Tsai M; Galli SJ. 2004. Mast cells promote homeostasis by limiting endothelin-1-induced toxicity. Nature 432(7016):512-6. [PubMed: 15543132]  [MGI Ref ID J:94154]

McLachlan JB; Shelburne CP; Hart JP; Pizzo SV; Goyal R; Brooking-Dixon R; Staats HF; Abraham SN. 2008. Mast cell activators: a new class of highly effective vaccine adjuvants. Nat Med 14(5):536-41. [PubMed: 18425129]  [MGI Ref ID J:136707]

Metz M; Piliponsky AM; Chen CC; Lammel V; Abrink M; Pejler G; Tsai M; Galli SJ. 2006. Mast cells can enhance resistance to snake and honeybee venoms. Science 313(5786):526-30. [PubMed: 16873664]  [MGI Ref ID J:110940]

Milenkovic N; Frahm C; Gassmann M; Griffel C; Erdmann B; Birchmeier C; Lewin GR; Garratt AN. 2007. Nociceptive tuning by stem cell factor/c-Kit signaling. Neuron 56(5):893-906. [PubMed: 18054864]  [MGI Ref ID J:132723]

Mintz B; Klein-Szanto AJ. 1992. Malignancy of eye melanomas originating in the retinal pigment epithelium of transgenic mice after genetic ablation of choroidal melanocytes. Proc Natl Acad Sci U S A 89(23):11421-5. [PubMed: 1454829]  [MGI Ref ID J:95743]

Miyajima I; Dombrowicz D; Martin TR; Ravetch JV; Kinet JP; Galli SJ. 1997. Systemic anaphylaxis in the mouse can be mediated largely through IgG1 and Fc gammaRIII. Assessment of the cardiopulmonary changes, mast cell degranulation, and death associated with active or IgE- or IgG1-dependent passive anaphylaxis. J Clin Invest 99(5):901-14. [PubMed: 9062348]  [MGI Ref ID J:78659]

Miyata M; Hatsushika K; Ando T; Shimokawa N; Ohnuma Y; Katoh R; Suto H; Ogawa H; Masuyama K; Nakao A. 2008. Mast cell regulation of epithelial TSLP expression plays an important role in the development of allergic rhinitis. Eur J Immunol 38(6):1487-92. [PubMed: 18461563]  [MGI Ref ID J:136211]

Miyata M; Nakamura Y; Shimokawa N; Ohnuma Y; Katoh R; Matsuoka S; Okumura K; Ogawa H; Masuyama K; Nakao A. 2009. Thymic stromal lymphopoietin is a critical mediator of IL-13-driven allergic inflammation. Eur J Immunol 39(11):3078-3083. [PubMed: 19658093]  [MGI Ref ID J:154206]

Morimoto K; Shirata N; Taketomi Y; Tsuchiya S; Segi-Nishida E; Inazumi T; Kabashima K; Tanaka S; Murakami M; Narumiya S; Sugimoto Y. 2014. Prostaglandin E2-EP3 signaling induces inflammatory swelling by mast cell activation. J Immunol 192(3):1130-7. [PubMed: 24342806]  [MGI Ref ID J:207320]

Morrow CM; Tyagi G; Simon L; Carnes K; Murphy KM; Cooke PS; Hofmann MC; Hess RA. 2009. Claudin 5 expression in mouse seminiferous epithelium is dependent upon the transcription factor ets variant 5 and contributes to blood-testis barrier function. Biol Reprod 81(5):871-9. [PubMed: 19571261]  [MGI Ref ID J:154522]

Mueller JL; Skaletsky H; Brown LG; Zaghlul S; Rock S; Graves T; Auger K; Warren WC; Wilson RK; Page DC. 2013. Independent specialization of the human and mouse X chromosomes for the male germ line. Nat Genet 45(9):1083-7. [PubMed: 23872635]  [MGI Ref ID J:205313]

Mullaly SC; Kubes P. 2007. Mast cell-expressed complement receptor, not TLR2, is the main detector of zymosan in peritonitis. Eur J Immunol 37(1):224-34. [PubMed: 17154261]  [MGI Ref ID J:117071]

Mullaly SC; Kubes P. 2006. The role of TLR2 in vivo following challenge with Staphylococcus aureus and prototypic ligands. J Immunol 177(11):8154-63. [PubMed: 17114491]  [MGI Ref ID J:140680]

Munks MW; McKee AS; Macleod MK; Powell RL; Degen JL; Reisdorph NA; Kappler JW; Marrack P. 2010. Aluminum adjuvants elicit fibrin-dependent extracellular traps in vivo. Blood 116(24):5191-9. [PubMed: 20876456]  [MGI Ref ID J:167390]

Murphy JT; Burey AP; Beebe AM; Gu D; Presta LG; Merghoub T; Wolchok JD. 2014. Anaphylaxis caused by repetitive doses of a GITR agonist monoclonal antibody in mice. Blood 123(14):2172-80. [PubMed: 24558202]  [MGI Ref ID J:210752]

Musio S; Pedotti P; Mantegazza R; Ohtsu H; Boon L; Steinman L; Galli SJ; Pedotti R. 2009. Anaphylaxis to a self-peptide in the absence of mast cells or histamine. Lab Invest 89(4):398-405. [PubMed: 19188909]  [MGI Ref ID J:146849]

Muto S; Katsuki M; Horie S. 2007. Decreased c-kit function inhibits enhanced skin carcinogenesis in c-Ha-ras protooncogene transgenic mice. Cancer Sci 98(10):1549-56. [PubMed: 17683512]  [MGI Ref ID J:138103]

Nagai R; Shinomura M; Kishi K; Aiyama Y; Harikae K; Sato T; Kanai-Azuma M; Kurohmaru M; Tsunekawa N; Kanai Y. 2012. Dynamics of GFRalpha1-positive spermatogonia at the early stages of colonization in the recipient testes of W/W(nu) male mice. Dev Dyn 241(8):1374-84. [PubMed: 22745058]  [MGI Ref ID J:185654]

Nakae S; Suto H; Berry GJ; Galli SJ. 2007. Mast cell-derived TNF can promote Th17 cell-dependent neutrophil recruitment in ovalbumin-challenged OTII mice. Blood 109(9):3640-8. [PubMed: 17197430]  [MGI Ref ID J:145332]

Nakano N; Nishiyama C; Kanada S; Niwa Y; Shimokawa N; Ushio H; Nishiyama M; Okumura K; Ogawa H. 2007. Involvement of mast cells in IL-12/23 p40 production is essential for survival from polymicrobial infections. Blood 109(11):4846-55. [PubMed: 17289816]  [MGI Ref ID J:145437]

Nakazawa S; Sakanaka M; Furuta K; Natsuhara M; Takano H; Tsuchiya S; Okuno Y; Ohtsu H; Nishibori M; Thurmond RL; Hirasawa N; Nakayama K; Ichikawa A; Sugimoto Y; Tanaka S. 2014. Histamine synthesis is required for granule maturation in murine mast cells. Eur J Immunol 44(1):204-14. [PubMed: 24002822]  [MGI Ref ID J:208216]

Nauta AC; Grova M; Montoro DT; Zimmermann A; Tsai M; Gurtner GC; Galli SJ; Longaker MT. 2013. Evidence that mast cells are not required for healing of splinted cutaneous excisional wounds in mice. PLoS One 8(3):e59167. [PubMed: 23544053]  [MGI Ref ID J:199526]

Nguyen M; Pace AJ; Koller BH. 2005. Age-induced reprogramming of mast cell degranulation. J Immunol 175(9):5701-7. [PubMed: 16237060]  [MGI Ref ID J:119387]

Nigrovic PA; Binstadt BA; Monach PA; Johnsen A; Gurish M; Iwakura Y; Benoist C; Mathis D; Lee DM. 2007. Mast cells contribute to initiation of autoantibody-mediated arthritis via IL-1. Proc Natl Acad Sci U S A 104(7):2325-30. [PubMed: 17277081]  [MGI Ref ID J:119744]

Nocka K; Tan JC; Chiu E; Chu TY; Ray P; Traktman P; Besmer P. 1990. Molecular bases of dominant negative and loss of function mutations at the murine c-kit/white spotting locus: W37, Wv, W41 and W. EMBO J 9(6):1805-13. [PubMed: 1693331]  [MGI Ref ID J:10528]

Norman MU; Hwang J; Hulliger S; Bonder CS; Yamanouchi J; Santamaria P; Kubes P. 2008. Mast cells regulate the magnitude and the cytokine microenvironment of the contact hypersensitivity response. Am J Pathol 172(6):1638-49. [PubMed: 18467702]  [MGI Ref ID J:136229]

Norton JT; Hayashi T; Crain B; Cho JS; Miller LS; Corr M; Carson DA. 2012. Cutting edge: nitrogen bisphosphonate-induced inflammation is dependent upon mast cells and IL-1. J Immunol 188(7):2977-80. [PubMed: 22387558]  [MGI Ref ID J:183090]

Ogawa T; Dobrinski I; Avarbock MR; Brinster RL. 2000. Transplantation of male germ line stem cells restores fertility in infertile mice [see comments] Nat Med 6(1):29-34. [PubMed: 10613820]  [MGI Ref ID J:59322]

Ohta H; Yomogida K; Dohmae K; Nishimune Y. 2000. Regulation of proliferation and differentiation in spermatogonial stem cells: the role of c-kit and its ligand SCF Development 127(10):2125-31. [PubMed: 10769236]  [MGI Ref ID J:61520]

Okumura LM; Lesch BJ; Page DC. 2013. The ligand binding domain of GCNF is not required for repression of pluripotency genes in mouse fetal ovarian germ cells. PLoS One 8(6):e66062. [PubMed: 23762465]  [MGI Ref ID J:204241]

Orinska Z; Bulanova E; Budagian V; Metz M; Maurer M; Bulfone-Paus S. 2005. TLR3-induced activation of mast cells modulates CD8+ T-cell recruitment. Blood 106(3):978-87. [PubMed: 15840693]  [MGI Ref ID J:117318]

Orinska Z; Foger N; Huber M; Marschall J; Mirghomizadeh F; Du X; Scheller M; Rosenstiel P; Goldmann T; Bollinger A; Beutler BA; Bulfone-Paus S. 2010. I787 provides signals for c-Kit receptor internalization and functionality that control mast cell survival and development. Blood 116(15):2665-75. [PubMed: 20595514]  [MGI Ref ID J:165878]

Orinska Z; Maurer M; Mirghomizadeh F; Bulanova E; Metz M; Nashkevich N; Schiemann F; Schulmistrat J; Budagian V; Giron-Michel J; Brandt E; Paus R; Bulfone-Paus S. 2007. IL-15 constrains mast cell-dependent antibacterial defenses by suppressing chymase activities. Nat Med 13(8):927-34. [PubMed: 17643110]  [MGI Ref ID J:125124]

Perry JM; Harandi OF; Porayette P; Hegde S; Kannan AK; Paulson RF. 2009. Maintenance of the BMP4-dependent stress erythropoiesis pathway in the murine spleen requires hedgehog signaling. Blood 113(4):911-8. [PubMed: 18927434]  [MGI Ref ID J:144571]

Piliponsky AM; Chen CC; Nishimura T; Metz M; Rios EJ; Dobner PR; Wada E; Wada K; Zacharias S; Mohanasundaram UM; Faix JD; Abrink M; Pejler G; Pearl RG; Tsai M; Galli SJ. 2008. Neurotensin increases mortality and mast cells reduce neurotensin levels in a mouse model of sepsis. Nat Med 14(4):392-8. [PubMed: 18376408]  [MGI Ref ID J:133676]

Propst F; Rosenberg MP; Oskarsson MK; Russell LB; Nguyen-Huu MC; Nadeau J; Jenkins NA; Copeland NG; Vande Woude GF. 1988. Genetic analysis and developmental regulation of testis-specific RNA expression of Mos, Abl, actin and Hox-1.4. Oncogene 2(3):227-33. [PubMed: 2895445]  [MGI Ref ID J:9103]

Puddington L; Olson S; Lefrancois L. 1994. Interactions between stem cell factor and c-Kit are required for intestinal immune system homeostasis. Immunity 1(9):733-9. [PubMed: 7534619]  [MGI Ref ID J:189422]

Pusch W; Jahner D; Ivell R. 1998. Molecular cloning and testicular expression of the gene transcripts encoding the murine multiubiquitin-chain-binding protein (Mcb1). Gene 207(1):19-24. [PubMed: 9511739]  [MGI Ref ID J:45944]

Rabionet M; van der Spoel AC; Chuang CC; von Tumpling-Radosta B; Litjens M; Bouwmeester D; Hellbusch CC; Korner C; Wiegandt H; Gorgas K; Platt FM; Grone HJ; Sandhoff R. 2008. Male germ cells require polyenoic sphingolipids with complex glycosylation for completion of meiosis: a link to ceramide synthase-3. J Biol Chem 283(19):13357-69. [PubMed: 18308723]  [MGI Ref ID J:137091]

Ramos L; Pena G; Cai B; Deitch EA; Ulloa L. 2010. Mast cell stabilization improves survival by preventing apoptosis in sepsis. J Immunol 185(1):709-16. [PubMed: 20519642]  [MGI Ref ID J:161434]

Rankin AL; Mumm JB; Murphy E; Turner S; Yu N; McClanahan TK; Bourne PA; Pierce RH; Kastelein R; Pflanz S. 2010. IL-33 induces IL-13-dependent cutaneous fibrosis. J Immunol 184(3):1526-35. [PubMed: 20042577]  [MGI Ref ID J:159528]

Rao KN; Smuda C; Gregory GD; Min B; Brown MA. 2013. Ikaros limits basophil development by suppressing C/EBP-alpha expression. Blood 122(15):2572-81. [PubMed: 23990620]  [MGI Ref ID J:203433]

Reil JC; Gilles S; Zahler S; Brandl A; Drexler H; Hultner L; Matrisian LM; Welsch U; Becker BF. 2007. Insights from knock-out models concerning postischemic release of TNFalpha from isolated mouse hearts. J Mol Cell Cardiol 42(1):133-41. [PubMed: 17101148]  [MGI Ref ID J:119661]

Reith AD; Rottapel R; Giddens E; Brady C; Forrester L; Bernstein A. 1990. W mutant mice with mild or severe developmental defects contain distinct point mutations in the kinase domain of the c-kit receptor. Genes Dev 4(3):390-400. [PubMed: 1692559]  [MGI Ref ID J:28221]

Rijnierse A; Koster AS; Nijkamp FP; Kraneveld AD. 2006. Critical role for mast cells in the pathogenesis of 2,4-dinitrobenzene-induced murine colonic hypersensitivity reaction. J Immunol 176(7):4375-84. [PubMed: 16547276]  [MGI Ref ID J:129893]

Rocchi R; Kimura H; Tzou SC; Suzuki K; Rose NR; Pinchera A; Ladenson PW; Caturegli P. 2007. Toll-like receptor-MyD88 and Fc receptor pathways of mast cells mediate the thyroid dysfunctions observed during nonthyroidal illness. Proc Natl Acad Sci U S A 104(14):6019-24. [PubMed: 17389381]  [MGI Ref ID J:120373]

Rodewald HR; Brocker T; Haller C. 1999. Developmental dissociation of thymic dendritic cell and thymocyte lineages revealed in growth factor receptor mutant mice. Proc Natl Acad Sci U S A 96(26):15068-73. [PubMed: 10611339]  [MGI Ref ID J:59081]

Rodewald HR; Haller C. 1998. Antigen-receptor junctional diversity in growth-factor-receptor mutant mice. Dev Comp Immunol 22(3):351-65. [PubMed: 9700464]  [MGI Ref ID J:111311]

Rodewald HR; Kretzschmar K; Swat W; Takeda S. 1995. Intrathymically expressed c-kit ligand (stem cell factor) is a major factor driving expansion of very immature thymocytes in vivo. Immunity 3(3):313-9. [PubMed: 7552996]  [MGI Ref ID J:28959]

Rodewald HR; Ogawa M; Haller C; Waskow C; DiSanto JP. 1997. Pro-thymocyte expansion by c-kit and the common cytokine receptor gamma chain is essential for repertoire formation. Immunity 6(3):265-72. [PubMed: 9075927]  [MGI Ref ID J:39091]

Rodewald HR; Waskow C; Haller C. 2001. Essential requirement for c-kit and common gamma chain in thymocyte development cannot be overruled by enforced expression of Bcl-2. J Exp Med 193(12):1431-7. [PubMed: 11413198]  [MGI Ref ID J:70009]

Ross AJ; Amy SP; Mahar PL; Lindsten T; Knudson CM; Thompson CB; Korsmeyer SJ; MacGregor GR. 2001. BCLW Mediates Survival of Postmitotic Sertoli Cells by Regulating BAX Activity. Dev Biol 239(2):295-308. [PubMed: 11784036]  [MGI Ref ID J:72582]

Ruschitzka FT; Wenger RH; Stallmach T; Quaschning T; de Wit C; Wagner K; Labugger R; Kelm M; Noll G; Rulicke T; Shaw S; Lindberg RL; Rodenwaldt B; Lutz H; Bauer C; Luscher TF; Gassmann M. 2000. Nitric oxide prevents cardiovascular disease and determines survival in polyglobulic mice overexpressing erythropoietin Proc Natl Acad Sci U S A 97(21):11609-13. [PubMed: 11027359]  [MGI Ref ID J:65257]

Russell ES. 1970. Abnormalities of erythropoiesis associated with mutant genes in mice. In: Regulation of Hematopoiesis. Appleton-Century-Crofts, New York.  [MGI Ref ID J:27511]

Russell ES; Bernstein SE. 1966. Blood and Blood Formation. In: Biology of the Laboratory Mouse. McGraw Hill, New York.  [MGI Ref ID J:24829]

Russell JS; McGee SO; Ip MM; Kuhlmann D; Masso-Welch PA. 2007. Conjugated linoleic acid induces mast cell recruitment during mouse mammary gland stromal remodeling. J Nutr 137(5):1200-7. [PubMed: 17449582]  [MGI Ref ID J:121742]

Sadik CD; Kim ND; Iwakura Y; Luster AD. 2012. Neutrophils orchestrate their own recruitment in murine arthritis through C5aR and FcgammaR signaling. Proc Natl Acad Sci U S A 109(46):E3177-85. [PubMed: 23112187]  [MGI Ref ID J:191734]

Sassa S; Bernstein SE. 1978. Studies of erythrocyte protoporphyrin in anemic mutant mice: use of a modified hematofluorometer for the detection of heterozygotes for hemolytic disease. Exp Hematol 6(5):479-87. [PubMed: 658175]  [MGI Ref ID J:5985]

Sayed BA; Christy AL; Walker ME; Brown MA. 2010. Meningeal mast cells affect early T cell central nervous system infiltration and blood-brain barrier integrity through TNF: a role for neutrophil recruitment? J Immunol 184(12):6891-900. [PubMed: 20488789]  [MGI Ref ID J:161131]

Sayed BA; Walker ME; Brown MA. 2011. Cutting edge: mast cells regulate disease severity in a relapsing-remitting model of multiple sclerosis. J Immunol 186(6):3294-8. [PubMed: 21325623]  [MGI Ref ID J:169755]

Schmidt-Ott KM; Chen X; Paragas N; Levinson RS; Mendelsohn CL; Barasch J. 2006. c-kit delineates a distinct domain of progenitors in the developing kidney. Dev Biol 299(1):238-49. [PubMed: 16942767]  [MGI Ref ID J:114384]

Schneider LA; Schlenner SM; Feyerabend TB; Wunderlin M; Rodewald HR. 2007. Molecular mechanism of mast cell mediated innate defense against endothelin and snake venom sarafotoxin. J Exp Med 204(11):2629-39. [PubMed: 17923505]  [MGI Ref ID J:125964]

Secor VH; Secor WE; Gutekunst CA; Brown MA. 2000. Mast cells are essential for early onset and severe disease in a murine model of multiple sclerosis. J Exp Med 191(5):813-22. [PubMed: 10704463]  [MGI Ref ID J:60917]

Serizawa I; Koezuka Y; Amao H; Saito TR; Takahashi KW. 2000. Functional natural killer T cells in experimental mouse strains, including NK1.1- strains Exp Anim 49(3):171-80. [PubMed: 11109539]  [MGI Ref ID J:64139]

Sha L; Farrugia G; Harmsen WS; Szurszewski JH. 2007. Membrane potential gradient is carbon monoxide-dependent in mouse and human small intestine. Am J Physiol Gastrointest Liver Physiol 293(2):G438-45. [PubMed: 17510199]  [MGI Ref ID J:125239]

Sharkis SJ; Wiktor-Jedrzejczak W; Ahmed A; Santos GW; McKee A; Sell KW. 1978. Antitheta-sensitive regulatory cell (TSRC) and hematopoiesis: regulation of differentiation of transplanted stem cells in W/Wv anemic and normal mice. Blood 52(4):802-17. [PubMed: 28803]  [MGI Ref ID J:6030]

Siebenhaar F; Syska W; Weller K; Magerl M; Zuberbier T; Metz M; Maurer M. 2007. Control of Pseudomonas aeruginosa skin infections in mice is mast cell-dependent. Am J Pathol 170(6):1910-6. [PubMed: 17525259]  [MGI Ref ID J:122101]

Silvers WK. 1979. The Coat Colors of Mice; A Model for Mammalian Gene Action and Interaction. In: The Coat Colors of Mice. Springer-Verlag, New York.  [MGI Ref ID J:78801]

Sivarao DV; Mashimo H; Goyal RK. 2008. Pyloric sphincter dysfunction in nNOS-/- and W/Wv mutant mice: animal models of gastroparesis and duodenogastric reflux. Gastroenterology 135(4):1258-66. [PubMed: 18640116]  [MGI Ref ID J:142004]

Sivarao DV; Mashimo HL; Thatte HS; Goyal RK. 2001. Lower esophageal sphincter is achalasic in nNOS(-/-) and hypotensive in W/W(v) mutant mice. Gastroenterology 121(1):34-42. [PubMed: 11438492]  [MGI Ref ID J:70182]

Sokol CL; Barton GM; Farr AG; Medzhitov R. 2008. A mechanism for the initiation of allergen-induced T helper type 2 responses. Nat Immunol 9(3):310-8. [PubMed: 18300366]  [MGI Ref ID J:131552]

Sotnikov I; Veremeyko T; Starossom SC; Barteneva N; Weiner HL; Ponomarev ED. 2013. Platelets recognize brain-specific glycolipid structures, respond to neurovascular damage and promote neuroinflammation. PLoS One 8(3):e58979. [PubMed: 23555611]  [MGI Ref ID J:199888]

Spencer NJ; Sanders KM; Smith TK. 2003. Migrating motor complexes do not require electrical slow waves in the mouse small intestine. J Physiol 553(Pt 3):881-93. [PubMed: 14514874]  [MGI Ref ID J:105487]

Strauss TJ; Castrillon DH; Hammes SR. 2011. GATA-like protein-1 (GLP-1) is required for normal germ cell development during embryonic oogenesis. Reproduction 141(2):173-81. [PubMed: 21123517]  [MGI Ref ID J:180844]

Strong LC; Hollander WF. 1953. Two non-allelic mutants resembling "W" in the house mouse J Hered 44:41-4.  [MGI Ref ID J:15330]

Subramanian A; Teal HE; Correll PH; Paulson RF. 2005. Resistance to friend virus-induced erythroleukemia in W/W(v) mice is caused by a spleen-specific defect which results in a severe reduction in target cells and a lack of Sf-Stk expression. J Virol 79(23):14586-94. [PubMed: 16282458]  [MGI Ref ID J:102884]

Sugihara A; Tsujimura T; Fujita Y; Nakata Y; Terada N. 1999. Evaluation of role of mast cells in the development of liver fibrosis using mast cell-deficient rats and mice. J Hepatol 30(5):859-67. [PubMed: 10365813]  [MGI Ref ID J:57192]

Sun J; Arias K; Alvarez D; Fattouh R; Walker T; Goncharova S; Kim B; Waserman S; Reed J; Coyle AJ; Jordana M. 2007. Impact of CD40 ligand, B cells, and mast cells in peanut-induced anaphylactic responses. J Immunol 179(10):6696-703. [PubMed: 17982059]  [MGI Ref ID J:154013]

Supajatura V; Ushio H; Nakao A; Akira S; Okumura K; Ra C; Ogawa H. 2002. Differential responses of mast cell Toll-like receptors 2 and 4 in allergy and innate immunity. J Clin Invest 109(10):1351-9. [PubMed: 12021251]  [MGI Ref ID J:195474]

Suto H; Nakae S; Kakurai M; Sedgwick JD; Tsai M; Galli SJ. 2006. Mast cell-associated TNF promotes dendritic cell migration. J Immunol 176(7):4102-12. [PubMed: 16547246]  [MGI Ref ID J:129877]

Suzuki M; Nakano K. 1996. Increase in histamine synthesis by liver macrophages in CCl4-injured mast cell-deficient W/Wv mice. Biochem Pharmacol 52(5):809-13. [PubMed: 8765479]  [MGI Ref ID J:35601]

Tadokoro Y; Yomogida K; Ohta H; Tohda A; Nishimune Y. 2002. Homeostatic regulation of germinal stem cell proliferation by the GDNF/FSH pathway. Mech Dev 113(1):29-39. [PubMed: 11900972]  [MGI Ref ID J:184664]

Takano H; Nakazawa S; Shirata N; Tamba S; Furuta K; Tsuchiya S; Morimoto K; Itano N; Irie A; Ichikawa A; Kimata K; Nakayama K; Sugimoto Y; Tanaka S. 2009. Involvement of CD44 in mast cell proliferation during terminal differentiation. Lab Invest 89(4):446-55. [PubMed: 19204665]  [MGI Ref ID J:146846]

Taketomi Y; Ueno N; Kojima T; Sato H; Murase R; Yamamoto K; Tanaka S; Sakanaka M; Nakamura M; Nishito Y; Kawana M; Kambe N; Ikeda K; Taguchi R; Nakamizo S; Kabashima K; Gelb MH; Arita M; Yokomizo T; Nakamura M; Watanabe K; Hirai H; Nakamura M; Okayama Y;Ra C; Aritake K; Urade Y; Morimoto K; Sugimoto Y; Shimizu T; Narumiya S; Hara S; Murakami M. 2013. Mast cell maturation is driven via a group III phospholipase A2-prostaglandin D2-DP1 receptor paracrine axis. Nat Immunol 14(6):554-63. [PubMed: 23624557]  [MGI Ref ID J:197334]

Tanaka A; Nomura Y; Matsuda A; Ohmori K; Matsuda H. 2011. Mast cells function as an alternative modulator of adipogenesis through 15-deoxy-delta-12, 14-prostaglandin J2. Am J Physiol Cell Physiol 301(6):C1360-7. [PubMed: 21865589]  [MGI Ref ID J:178344]

Tang H; Ross A; Capel B. 2008. Expression and functional analysis of Gm114, a putative mammalian ortholog of Drosophila bam. Dev Biol 318(1):73-81. [PubMed: 18423593]  [MGI Ref ID J:136802]

Taube C; Miyahara N; Ott V; Swanson B; Takeda K; Loader J; Shultz LD; Tager AM; Luster AD; Dakhama A; Gelfand EW. 2006. The leukotriene B4 receptor (BLT1) is required for effector CD8+ T cell-mediated, mast cell-dependent airway hyperresponsiveness. J Immunol 176(5):3157-64. [PubMed: 16493075]  [MGI Ref ID J:129412]

Terauchi A; Kobayashi D; Mashimo H. 2005. Distinct roles of nitric oxide synthases and interstitial cells of Cajal in rectoanal relaxation. Am J Physiol Gastrointest Liver Physiol 289(2):G291-9. [PubMed: 15845873]  [MGI Ref ID J:100350]

Thuneberg L; Peters S. 2001. Toward a concept of stretch-coupling in smooth muscle. I. Anatomy of intestinal segmentation and sleeve contractions. Anat Rec 262(1):110-24. [PubMed: 11146434]  [MGI Ref ID J:66959]

Tilley SL; Tsai M; Williams CM; Wang ZS; Erikson CJ; Galli SJ; Koller BH. 2003. Identification of A3 receptor- and mast cell-dependent and -independent components of adenosine-mediated airway responsiveness in mice. J Immunol 171(1):331-7. [PubMed: 12817015]  [MGI Ref ID J:123463]

Tokuda M; Kadokawa Y; Kurahashi H; Marunouchi T. 2007. CDH1 is a specific marker for undifferentiated spermatogonia in mouse testes. Biol Reprod 76(1):130-41. [PubMed: 17035642]  [MGI Ref ID J:117360]

Tsujimura T; Koshimizu U; Katoh H; Isozaki K; Kanakura Y; Tono T; Adachi S; Kasugai T; Tei H; Nishimune Y; Nomura S; Kitamura Y. 1993. Mast cell number in the skin of heterozygotes reflects the molecular nature of c-kit mutation. Blood 81(10):2530-8. [PubMed: 7683920]  [MGI Ref ID J:27513]

Tsujimura Y; Obata K; Mukai K; Shindou H; Yoshida M; Nishikado H; Kawano Y; Minegishi Y; Shimizu T; Karasuyama H. 2008. Basophils play a pivotal role in immunoglobulin-G-mediated but not immunoglobulin-E-mediated systemic anaphylaxis. Immunity 28(4):581-9. [PubMed: 18342553]  [MGI Ref ID J:134463]

Turner RT; Wong CP; Iwaniec UT. 2011. Effect of reduced c-Kit signaling on bone marrow adiposity. Anat Rec (Hoboken) 294(7):1126-34. [PubMed: 21634019]  [MGI Ref ID J:175574]

Veerappan A; Reid AC; O'Connor N; Mora R; Brazin JA; Estephan R; Kameue T; Chen J; Felsen D; Seshan SV; Poppas DP; Maack T; Silver RB. 2012. Mast cells are required for the development of renal fibrosis in the rodent unilateral ureteral obstruction model. Am J Physiol Renal Physiol 302(1):F192-204. [PubMed: 21957176]  [MGI Ref ID J:179998]

Vincent L; Vang D; Nguyen J; Gupta M; Luk K; Ericson ME; Simone DA; Gupta K. 2013. Mast cell activation contributes to sickle cell pathobiology and pain in mice. Blood 122(11):1853-62. [PubMed: 23775718]  [MGI Ref ID J:202290]

Wang CH; Anderson N; Li SH; Szmitko PE; Cherng WJ; Fedak PW; Fazel S; Li RK; Yau TM; Weisel RD; Stanford WL; Verma S. 2006. Stem cell factor deficiency is vasculoprotective: unraveling a new therapeutic potential of imatinib mesylate. Circ Res 99(6):617-25. [PubMed: 16931795]  [MGI Ref ID J:125065]

Wang Z; Lai Y; Bernard JJ; Macleod DT; Cogen AL; Moss B; Di Nardo A. 2012. Skin mast cells protect mice against vaccinia virus by triggering mast cell receptor S1PR2 and releasing antimicrobial peptides. J Immunol 188(1):345-57. [PubMed: 22140255]  [MGI Ref ID J:180895]

Warr N; Carre GA; Siggers P; Faleato JV; Brixey R; Pope M; Bogani D; Childers M; Wells S; Scudamore CL; Tedesco M; del Barco Barrantes I; Nebreda AR; Trainor PA; Greenfield A. 2012. Gadd45gamma and Map3k4 interactions regulate mouse testis determination via p38 MAPK-mediated control of Sry expression. Dev Cell 23(5):1020-31. [PubMed: 23102580]  [MGI Ref ID J:191096]

Waskow C; Bartels S; Schlenner SM; Costa C; Rodewald HR. 2007. Kit is essential for PMA-inflammation-induced mast-cell accumulation in the skin. Blood 109(12):5363-70. [PubMed: 17327401]  [MGI Ref ID J:145426]

Waskow C; Paul S; Haller C; Gassmann M; Rodewald H. 2002. Viable c-Kit(W/W) Mutants Reveal Pivotal Role for c-Kit in the Maintenance of Lymphopoiesis. Immunity 17(3):277. [PubMed: 12354381]  [MGI Ref ID J:79128]

Waskow C; Terszowski G; Costa C; Gassmann M; Rodewald HR. 2004. Rescue of lethal c-KitW/W mice by erythropoietin. Blood 104(6):1688-95. [PubMed: 15178584]  [MGI Ref ID J:92961]

Wehrle-Haller B; Weston JA. 1995. Soluble and cell-bound forms of steel factor activity play distinct roles in melanocyte precursor dispersal and survival on the lateral neural crest migration pathway. Development 121(3):731-42. [PubMed: 7536655]  [MGI Ref ID J:40215]

Wei CC; Hase N; Inoue Y; Bradley EW; Yahiro E; Li M; Naqvi N; Powell PC; Shi K; Takahashi Y; Saku K; Urata H; Dell'italia LJ; Husain A. 2010. Mast cell chymase limits the cardiac efficacy of Ang I-converting enzyme inhibitor therapy in rodents. J Clin Invest 120(4):1229-39. [PubMed: 20335663]  [MGI Ref ID J:159675]

Weller K; Foitzik K; Paus R; Syska W; Maurer M. 2006. Mast cells are required for normal healing of skin wounds in mice. FASEB J 20(13):2366-8. [PubMed: 16966487]  [MGI Ref ID J:129739]

Wershil BK; Castagliuolo I; Pothoulakis C. 1998. Direct evidence of mast cell involvement in Clostridium difficile toxin A-induced enteritis in mice. Gastroenterology 114(5):956-64. [PubMed: 9558284]  [MGI Ref ID J:107762]

Wershil BK; Theodos CM; Galli SJ; Titus RG. 1994. Mast cells augment lesion size and persistence during experimental Leishmania major infection in the mouse. J Immunol 152(9):4563-71. [PubMed: 8157970]  [MGI Ref ID J:17706]

White RA; Sokolovsky IV; Britt MI; Nsumu NN; Logsdon DP; McNulty SG; Wilmes LA; Brewer BP; Wirtz E; Joyce HR; Fegley B; Smith A; Heruth DP. 2009. Hematologic characterization and chromosomal localization of the novel dominantly inherited mouse hemolytic anemia, neonatal anemia (Nan). Blood Cells Mol Dis 43(2):141-8. [PubMed: 19409822]  [MGI Ref ID J:162530]

Williams CM; Galli SJ. 2000. Mast cells can amplify airway reactivity and features of chronic inflammation in an asthma model in mice. J Exp Med 192(3):455-62. [PubMed: 10934234]  [MGI Ref ID J:63872]

Won KJ; Sanders KM; Ward SM. 2005. Interstitial cells of Cajal mediate mechanosensitive responses in the stomach. Proc Natl Acad Sci U S A 102(41):14913-8. [PubMed: 16204383]  [MGI Ref ID J:102473]

Wulff BC; Parent AE; Meleski MA; DiPietro LA; Schrementi ME; Wilgus TA. 2012. Mast cells contribute to scar formation during fetal wound healing. J Invest Dermatol 132(2):458-65. [PubMed: 21993557]  [MGI Ref ID J:183187]

Yang-Feng TL; Ullrich A; Francke U. 1987. The oncogene c-kit (KIT) is located on human Chromosome 4 and mouse Chromosome 5. Cytogenet Cell Genet 46:723.  [MGI Ref ID J:12308]

Ye L; Zhang EY; Xiong Q; Astle CM; Zhang P; Li Q; From AH; Harrison DE; Zhang JJ. 2012. Aging Kit mutant mice develop cardiomyopathy. PLoS One 7(3):e33407. [PubMed: 22428044]  [MGI Ref ID J:187053]

Yokozeki H; Wu MH; Sumi K; Igawa K; Miyazaki Y; Katayama I; Takeda K; Akira S; Nishioka K. 2003. Th2 cytokines, IgE and mast cells play a crucial role in the induction of para-phenylenediamine-induced contact hypersensitivity in mice. Clin Exp Immunol 132(3):385-92. [PubMed: 12780683]  [MGI Ref ID J:83737]

Younan G; Suber F; Xing W; Shi T; Kunori Y; Abrink M; Pejler G; Schlenner SM; Rodewald HR; Moore FD Jr; Stevens RL; Adachi R; Austen KF; Gurish MF. 2010. The inflammatory response after an epidermal burn depends on the activities of mouse mast cell proteases 4 and 5. J Immunol 185(12):7681-90. [PubMed: 21076070]  [MGI Ref ID J:167465]

Zhou JS; Xing W; Friend DS; Austen KF; Katz HR. 2007. Mast cell deficiency in Kit(W-sh) mice does not impair antibody-mediated arthritis. J Exp Med 204(12):2797-802. [PubMed: 17998392]  [MGI Ref ID J:128512]

de Lorijn F; de Jonge WJ; Wedel T; Vanderwinden JM; Benninga MA; Boeckxstaens GE. 2005. Interstitial cells of Cajal are involved in the afferent limb of the rectoanal inhibitory reflex. Gut 54(8):1107-13. [PubMed: 16009682]  [MGI Ref ID J:194727]

oRdog T; Baldo M; Danko R; Sanders KM. 2002. Plasticity of electrical pacemaking by interstitial cells of Cajal and gastric dysrhythmias in W/W mutant mice. Gastroenterology 123(6):2028-40. [PubMed: 12454859]  [MGI Ref ID J:80620]

f related

Bannerman RM; Edwards JA; Pinkerton PH. 1973. Hereditary disorders of the red cell in animals. Prog Hematol 8:131-79. [PubMed: 4596202]  [MGI Ref ID J:5439]

Bernstein SE. 1969. Hereditary disorders of the rodent erythron. In: Genetics in Laboratory Animal Medicine. Natl Acad Sci Publ, Washington, DC.  [MGI Ref ID J:30699]

Chui DH; Patterson M; Bayley ST. 1977. Unequal alpha and beta globin mRNA in reticulocytes of normal and mutant (f/f) fetal mice Blood 50(Suppl 1):104 (Abstr.).  [MGI Ref ID J:30711]

Chui DH; Sweeney GD; Patterson M; Russell ES. 1977. Hemoglobin synthesis in siderocytes of flexed-tailed mutant (f/f) fetal mice. Blood 50(1):165-77. [PubMed: 559515]  [MGI Ref ID J:5827]

Cole RJ; Garlick J; Cheek EM. 1975. Activities of haem synthetic enzymes in blood cells of pre-natal flexed-tailed (f/f) anaemic mice. J Embryol Exp Morphol 34(2):373-86. [PubMed: 1194836]  [MGI Ref ID J:5591]

Cole RJ; Regan T. 1976. Haemopoietic progenitor cells in prenatal congenitally anaemic 'flexed-tailed' (f/f) mice. Br J Haematol 33(3):387-94. [PubMed: 1276083]  [MGI Ref ID J:5654]

Coleman DL; Russell ES; Levin EY. 1969. Enzymatic studies of the hemopoietic defect in flexed mice. Genetics 61(3):631-42. [PubMed: 5393940]  [MGI Ref ID J:152369]

Fleming MD; Campagna DR; Haslett JN; Trenor CC 3rd; Andrews NC. 2001. A mutation in a mitochondrial transmembrane protein is responsible for the pleiotropic hematological and skeletal phenotype of flexed-tail (f/f) mice. Genes Dev 15(6):652-7. [PubMed: 11274051]  [MGI Ref ID J:68377]

Gregory CJ; McCulloch EA; Till JE. 1975. The cellular basis for the defect in haemopoiesis in flexed-tailed mice. III. Restriction of the defect to erythropoietic progenitors capable of transient colony formation in vivo. Br J Haematol 30(4):401-10. [PubMed: 1201223]  [MGI Ref ID J:5582]

Gruneberg H. 1942. The anaemia of flexed-tailed mice (Mus musculus L.). II. Siderocytes J Genet 44:246-71.  [MGI Ref ID J:14979]

Gruneberg H. 1942. The anaemia of flexed-tailed mice (mus musculus L) J Genet 43:45-68.  [MGI Ref ID J:164714]

Hegde S; Lenox LE; Lariviere A; Porayette P; Perry JM; Yon M; Paulson RF. 2007. An intronic sequence mutated in flexed-tail mice regulates splicing of Smad5. Mamm Genome 18(12):852-60. [PubMed: 18060457]  [MGI Ref ID J:128616]

Hunt HR; Mixter R; Permar D. 1933. Flexed Tail in the Mouse, Mus Musculus. Genetics 18(4):335-66. [PubMed: 17246696]  [MGI Ref ID J:12951]

Kamenoff RJ. 1935. Effects of the flexed-tailed gene on the development of the house mouse. J Morphol 58:117-155.  [MGI Ref ID J:13090]

Kreimer-Birnbaum M; Bannerman RM; Russell ES; Bernstein SE. 1972. Pyrrole pigments in normal and congenitally anaemic mice (+:+, W-W v , ha-ha, nb-nb, mk-mk, f-f and sla-Y). Comp Biochem Physiol A 43(1):21-30. [PubMed: 4404581]  [MGI Ref ID J:31039]

Lenox LE; Perry JM; Paulson RF. 2005. BMP4 and Madh5 regulate the erythroid response to acute anemia. Blood 105(7):2741-8. [PubMed: 15591122]  [MGI Ref ID J:98445]

Lenox LE; Shi L; Hegde S; Paulson RF. 2009. Extramedullary erythropoiesis in the adult liver requires BMP-4/Smad5-dependent signaling. Exp Hematol 37(5):549-58. [PubMed: 19375646]  [MGI Ref ID J:151008]

Oberhauser AF; Fernandez JM. 1996. A fusion pore phenotype in mast cells of the ruby-eye mouse. Proc Natl Acad Sci U S A 93(25):14349-54. [PubMed: 8962054]  [MGI Ref ID J:37255]

Porayette P; Paulson RF. 2008. BMP4/Smad5 dependent stress erythropoiesis is required for the expansion of erythroid progenitors during fetal development. Dev Biol 317(1):24-35. [PubMed: 18374325]  [MGI Ref ID J:136155]

Russell ES. 1970. Abnormalities of erythropoiesis associated with mutant genes in mice. In: Regulation of Hematopoiesis. Appleton-Century-Crofts, New York.  [MGI Ref ID J:27511]

Russell ES. 1979. Hereditary anemias of the mouse: a review for geneticists. Adv Genet 20:357-459. [PubMed: 390999]  [MGI Ref ID J:25355]

Russell ES; Bernstein SE. 1966. Blood and Blood Formation. In: Biology of the Laboratory Mouse. McGraw Hill, New York.  [MGI Ref ID J:24829]

Sotelo C. 1990. Axonal abnormalities in cerebellar Purkinje cells of the 'hyperspiny Purkinje cell' mutant mouse. J Neurocytol 19(5):737-55. [PubMed: 2077114]  [MGI Ref ID J:106784]

Urlando C; Krasnoshtein F; Heddle JA; Buchwald M. 1996. Assessment of the flexed-tail mouse as a possible model for Fanconi anemia: analysis of mitomycin C-induced micronuclei. Mutat Res 370(2):99-106. [PubMed: 8879267]  [MGI Ref ID J:35839]

Wevrick R; Barker JE; Nadeau JH; Szpirer C; Buchwald M. 1993. Mapping of the murine and rat Facc genes and assessment of flexed-tail as a candidate mouse homolog of Fanconi anemia group C. Mamm Genome 4(8):440-4. [PubMed: 7690622]  [MGI Ref ID J:13598]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $3300.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We willfulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $4290.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We willfulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Control Information

  Control
   Wild-type from the colony
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

Important Note

This strain is homozygous for f.

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.


See Terms of Use tab for General Terms and Conditions


The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
Ordering Information
JAX® Mice
Surgical and Preconditioning Services
JAX® Services
Customer Services and Support
Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
Technical Support Email Form

Terms of Use

Terms of Use


General Terms and Conditions


Contact information

General inquiries regarding Terms of Use

Contracts Administration

phone:207-288-6470

JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


(6.6)