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- Description
- Phenotype
- Genes & alleles
- Genotyping
- Health & husbandry
- References
- Purchasing information
- Terms of Use
Description
The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.
Strain Information
Type Congenic; Mutant Strain; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Species laboratory mouse Background Strain C57BL/6J Donor Strain AKD2 F1 (AKR/J x DBA/2J)F1 Generation N40p Development
Himalayan, an allele at the tryosonase locus, arose spontaneously in the offspring of a cross between a DBA/2J male and an AKR/J female at The Jackson Laboratory in 1958. An affected male was backcrosses to an AKR/J female and the Tyrc-h/Tyrc carriers were mated to a C57BL/10Gn. Pairs were mated to produce the Tyrc-h/Tyrc-h mouse. The mutation was backcrossed onto strain C57BL/6J and was cryopreserved in 1987 by mating B6.Cg-Tyrc-h homozygous males at N36F1 to C57BL/6J females.
Related Strains
Strains carrying Tyrc-h allele
000206 STOCK a/a Tyrc-h/J View Strains carrying Tyrc-h (1 strain)
Phenotype
Phenotype Information
assigned by genotype
The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.
Tyrc-h/Tyrc-h
involves: C57BL/6
- pigmentation phenotype
- diluted coat color (MGI Ref ID J:6611)
- mice have slight pigmentation of the coat
- the amount of melanin found in anagen hairbulbs is reduced by more than 10-fold compared to wild-type mice
- skin/coat/nails phenotype
- diluted coat color (MGI Ref ID J:6611)
- mice have slight pigmentation of the coat
- the amount of melanin found in anagen hairbulbs is reduced by more than 10-fold compared to wild-type mice
Tyrc-h/Tyrc-h
involves: AKR/J * DBA/2J
- pigmentation phenotype
- abnormal coat/hair pigmentation (MGI Ref ID J:13075)
- diluted coat color (MGI Ref ID J:13075)
- the fully grown juvenile coat is pale tan with little evidence of darkening of extremities except the tail
- absent eye pigmentation (MGI Ref ID J:13075)
- at birth
- reduced eye pigmentation (MGI Ref ID J:13075)
- pink eye color of the new born darkens to ruby-colored by weaning
- skin/coat/nails phenotype
- abnormal coat appearance (MGI Ref ID J:13075)
- at one week of age affected mice are slightly darker than albinos, particularly on tail
- the body coat color may range from unifrom to slightly lighter dorsal and ventral across the shoulders, darker toward the tail where a very dark ring of body fur develops adjacent to the tail
- at first molt the nose, ears, tail, and scrotum but not the feet become considerably darker; the rest of the body becomes lighter
- dark hair on the nose extends back to the anterior border of the eyes
- abnormal coat/hair pigmentation (MGI Ref ID J:13075)
- diluted coat color (MGI Ref ID J:13075)
- the fully grown juvenile coat is pale tan with little evidence of darkening of extremities except the tail
- vision/eye phenotype
- absent eye pigmentation (MGI Ref ID J:13075)
- at birth
- reduced eye pigmentation (MGI Ref ID J:13075)
- pink eye color of the new born darkens to ruby-colored by weaning
This mouse can be used to support research in many areas including:Tyrc-h related
Dermatology Research
Color and White Spotting Defects
Developmental Biology Research
Neurodevelopmental Defects
Skeletal Defects
Mouse/Human Gene Homologs
albinism, tyrosine negative
Genes & Alleles
Gene & Allele Information
| Allele Symbol | Tyrc-h | ||
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| Allele Name | himalayan | ||
| Allele Type | Spontaneous | ||
| Strain of Origin | (DBA/2 x AKR/J)F1 | ||
| Gene Symbol and Name | Tyr, tyrosinase | ||
| Chromosome | 7 | ||
| Gene Common Name(s) | C; OCA1A; OCAIA; SHEP3; albino; c; skc35; skin/coat color 35; | ||
| General Note | Melanin granules of the retina are indistinguishable from those of chinchilla or of wild-type homozygotes (J:5001). Pigment synthesis in himalayan mice is temperature-sensitive; pigment develops in growing hairs of mice housed at 15oC but not in those housed at 30oC (J:6275). In explanation of this effect, it has been shown that tyrosinase in these mice is heat-labile (J:12173), being maximally active at well below body temperature. Tyrosinase of Tyrch homozygotes is strongly bound by an inhibitor at 37oC but not at lower temperatures (J:6508). | ||
| Molecular Note | The mutation in the himalayan allele was found to be an A to G point mutation at nucleotide 1259 that results in an amino acid change at position 420 from histidine to arginine. [MGI Ref ID J:9824] | ||
Genotyping
Genotyping Information
This strain will not have a genotyping protocol or one is not currently available.
Helpful Links
Genotyping resources and troubleshooting
References
References
Additional References
Kidson S; Fabian B. 1979. Pigment synthesis in the Himalayan mouse. J Exp Zool 210(1):145-52. [PubMed: 536710] [MGI Ref ID J:6275]
Kidson SH; Fabian BC. 1981. The effect of temperature on tyrosinase activity in Himalayan mouse skin. J Exp Zool 215(1):91-7. [PubMed: 6785376] [MGI Ref ID J:6508]
Kwon BS; Halaban R; Chintamaneni C. 1989. Molecular basis of mouse Himalayan mutation. Biochem Biophys Res Commun 161(1):252-60. [PubMed: 2567165] [MGI Ref ID J:9824]
Kwon BS; Haq AK; Wakulchik M; Kestler D; Barton DE; Francke U; Lamoreux ML; Whitney JB 3d; Halaban R. 1989. Isolation, chromosomal mapping, and expression of the mouse tyrosinase gene. J Invest Dermatol 93(5):589-94. [PubMed: 2507645] [MGI Ref ID J:10058]
Kwon BS; Wakulchik M; Haq AK; Halaban R; Kestler D. 1988. Sequence analysis of mouse tyrosinase cDNA and the effect of melanotropin on its gene expression. Biochem Biophys Res Commun 153(3):1301-9. [PubMed: 3134020] [MGI Ref ID J:9242]
Porter S; Mintz B. 1991. Multiple alternatively spliced transcripts of the mouse tyrosinase-encoding gene. Gene 97(2):277-82. [PubMed: 1900251] [MGI Ref ID J:11014]
Ruppert S; Muller G; Kwon B; Schutz G. 1988. Multiple transcripts of the mouse tyrosinase gene are generated by alternative splicing. EMBO J 7(9):2715-22. [PubMed: 2846281] [MGI Ref ID J:9439]
Tyrc-h relatedColeman DL. 1962. Effect of genic substitution on the incorporation of tyrosine into the melanin of mouse skin. Arch Biochem Biophys 96:562-8. [PubMed: 13880466] [MGI Ref ID J:12173]
Dunn LC. 1936. Studies on multiple allelomorphic series in the house mouse. I. Description of agouti and albino series of allelomorphs J Genet 33:443-53. [MGI Ref ID J:22600]
Green MC. 1961. Himalayan, a new allele of albino in the mouse. J Hered 52:73-75. [MGI Ref ID J:13075]
Green MC. 1959. New mutant: Himalayan, symbol c<h>. Mouse News Lett 21:46. [MGI Ref ID J:24726]
Kidson S; Fabian B. 1979. Pigment synthesis in the Himalayan mouse. J Exp Zool 210(1):145-52. [PubMed: 536710] [MGI Ref ID J:6275]
Kidson SH; Fabian BC. 1981. The effect of temperature on tyrosinase activity in Himalayan mouse skin. J Exp Zool 215(1):91-7. [PubMed: 6785376] [MGI Ref ID J:6508]
Kwon BS; Halaban R; Chintamaneni C. 1989. Molecular basis of mouse Himalayan mutation. Biochem Biophys Res Commun 161(1):252-60. [PubMed: 2567165] [MGI Ref ID J:9824]
Moyer FH. 1966. Genetic variations in the fine structure and ontogeny of mouse melanin granules. Am Zool 6(1):43-66. [PubMed: 5902512] [MGI Ref ID J:5001]
Silvers WK. 1979. The Coat Colors of Mice; A Model for Mammalian Gene Action and Interaction. In: The Coat Colors of Mice. Springer-Verlag, New York. [MGI Ref ID J:78801]
Sweet HO. 1987. Acromelanic (c<a>) Mouse News Lett 78:56. [MGI Ref ID J:14994]
Townsend D; Witkop CJ Jr; Mattson J. 1981. Tyrosinase subcellular distribution and kinetic parameters in wild type and C-locus mutant C57BL/6J mice. J Exp Zool 216(1):113-9. [PubMed: 6793688] [MGI Ref ID J:6611]
Health & husbandry
Health & Colony Maintenance Information
Currently there no information available for this strain. This may be due to the supply level of this strain.
Purchasing information
Pricing, Supply Level & Notes, Controls, General Terms & Conditions
Pricing
| Pricing for USA, Canada and Mexico shipping destinations |
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Animals Provided
Price (US dollars $) Cryorecovery Fee $1900.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Additional Supply Details
| Pricing for International shipping destinations |
|
Animals Provided
Price (US dollars $) Cryorecovery Fee $2470.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Additional Supply Details
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Supply Details
| Standard Supply | Cryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information. |
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| Supply Notes |
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Payment Terms and Conditions
Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.
See Terms of Use tab for General Terms and Conditions
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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