Strain Name: |
B6.Cg-Tyrc-h/J |
|---|---|
Stock Number: |
000104 |
Availability: | Repository-Cryopreserved |
General Terms and Conditions |
| Genes & Alleles | Tyr; Tyrc-h; |
Product Information
Strain Details
Type JAX® GEMM® Strain - Congenic Additional information on JAX® GEMM® Strains. Type JAX® GEMM® Strain - Mutant Strain Species laboratory mouse Background Strain C57BL/6J Donor Strain AKD2 F1 (AKR/J x DBA/2J)F1 Generation N40p Strain Development
Himalayan, an allele at the tryosonase locus, arose spontaneously in the offspring of a cross between a DBA/2J male and an AKR/J female at The Jackson Laboratory in 1958. An affected male was backcrosses to an AKR/J female and the Tyrc-h/Tyrc carriers were mated to a C57BL/10Gn. Pairs were mated to produce the Tyrc-h/Tyrc-h mouse. The mutation was backcrossed onto strain C57BL/6J and was cryopreserved in 1987 by mating B6.Cg-Tyrc-h homozygous males at N36F1 to C57BL/6J females.
Mammalian Phenotype Terms assigned by genotype |
Gene & Allele Details
| Allele Symbol | Tyrc-h | ||
|---|---|---|---|
| Allele Name | himalayan | ||
| Strain of Origin | (DBA/2 x AKR/J)F1 | ||
| Gene Symbol and Name | Tyr, tyrosinase | ||
| Chromosome | 7 | ||
| Gene Common Name(s) | C; OCA1A; OCAIA; SHEP3; albino; c; skc35; skin/coat color 35; | ||
| General Note | Tyrc-h, himalayan. The himalayan mutation appeared in the offspring of a cross between the DBA/2 and AKR/J strains at The Jackson Laboratory. In homozygotes, the first coat is a uniform light tan. At the first molt, the body hair becomes lighter and the ears, nose, tail, and scrotum become dark as in Siamese cats. Body hair may be very light or quite sooty, depending on the genetic background. Eyes are slightly pigmented and appear red. Tyrc-h/Tyrc and Tyrc-h/Tyrc-e mice are intermediate between the homozygotes (J:13075). Melanin granules of the retina are indistinguishable from those of chinchilla or of wild-type homozygotes (J:5001). Pigment synthesis in himalayan mice is temperature-sensitive; pigment develops in growing hairs of mice housed at 15oC but not in those housed at 30oC (J:6275). In explanation of this effect, it has been shown that tyrosinase in these mice is heat-labile (J:12173), being maximally active at well below body temperature.Tyrosinase of Tyrch homozygotes is strongly bound by an inhibitor at 37oC but not at lower temperatures (J:6508). The mutation in the himalayan allele was found to be an A to G point mutation at nucleotide 1259 that results in an amino acid change at position 420 from histidine to arginine (J:9824). | ||
| Molecular Note | The mutation in the himalayan allele was found to be an A to G point mutation at nucleotide 1259 that results in an amino acid change at position 420 from histidine to arginine. [MGI Ref ID J:9824] | ||
Related Strains
Strains carrying Tyrc-h allele
000206 STOCK a/a Tyrc-h/J View Strains carrying Tyrc-h (1 strain)
Additional Web Information
Congenic Nomenclature
Research Applications
This mouse can be used to support research in many areas including:Tyrc-h related
Dermatology Research
Color and White Spotting Defects
Developmental Biology Research
Neurodevelopmental Defects
Skeletal Defects
Mouse/Human Gene Homologs
albinism, tyrosine negative
References
Additional ReferencesPrice and Supply Information
| Strain Name: | B6.Cg-Tyrc-h/J |
| Stock Number: | 000104 |
Price Details
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Supply Details
| Standard Supply | Repository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information. |
|---|---|
| Supply Notes |
Cryorecovery - Standard. The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two males and two females (two pairs) will be provided, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the delivery time to approximately 25 weeks. At least one member of each pair will be of known genotype and will carry the mutation if it is a mutant strain. Please note that pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Price represents a repository maintenance fee, which includes the cost of recovery of the strain from the cryopreservation resource and the periodic replacement of the frozen embryos used for recovery. Cryorecovery to establish a Dedicated Supply for greater quantities of mice. |
| Licensing | See General Terms and Conditions below |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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