Strain Name:

C57BL/6J-Ph/J

Stock Number:

000118

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Availability:

Cryopreserved - Ready for recovery

Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Type Coisogenic; Mutant Strain; Spontaneous Mutation;
Additional information on Genetically Engineered and Mutant Mice.
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Specieslaboratory mouse
GenerationN65p
Generation Definitions

Control Information

  Control
   000664 C57BL/6J
 
  Considerations for Choosing Controls

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

Ph/Ph+

        involves: C57BL/Gr
  • pigmentation phenotype
  • belly spot   (MGI Ref ID J:125080)
  • variable body spotting
    • heterozygotes have a large white patch of variable shape and size at the posterior extremity of the trunk, largely on the ventral side   (MGI Ref ID J:125080)
  • integument phenotype
  • belly spot   (MGI Ref ID J:125080)
  • variable body spotting
    • heterozygotes have a large white patch of variable shape and size at the posterior extremity of the trunk, largely on the ventral side   (MGI Ref ID J:125080)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Ph related

Cancer Research
Growth Factors/Receptors/Cytokines

Dermatology Research
Color and White Spotting Defects

Developmental Biology Research
Craniofacial and Palate Defects
Embryonic Lethality (Homozygous)
Neural Crest Defects

Immunology, Inflammation and Autoimmunity Research
Growth Factors/Receptors/Cytokines

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Ph
Allele Name patch
Allele Type Spontaneous
Common Name(s) PdgfrPh;
Strain of OriginC57BL/Gr
Gene Symbol and Name Ph, patch deletion region
Chromosome 5
General Note Repulsion double heterozygotes of Ph and the allele KitW-ct at the closely linked Kit locus (Ph +/+ KitW-ct) are more anemic than Kit heterozygotes (+ KitW-ct/+ +) alone, have significantly raised leucocyte counts, and are unduly sensitive to whole body X-irradiation, indicating that the Ph locus exerts some control over hematopoiesis (J:7216). Studies of Ph homozygous embryos suggest that Ph protein is required for normal development of non-neuronal neural crest-derived structures (J:1107) and visceral endoderm and mesoderm derivatives (J:1108).
Molecular Note A deletion region including the Pdgfra gene. Precise breakpoints have not been mapped, but does not extend into the coding sequences of the adjacent Kit gene. However, expression of Kit is altered in these mutants. [MGI Ref ID J:10920] [MGI Ref ID J:11255] [MGI Ref ID J:23149] [MGI Ref ID J:41383]

Genotyping

Genotyping Information


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Additional References

Duttlinger R; Manova K; Berrozpe G; Chu TY; DeLeon V; Timokhina I; Chaganti RS; Zelenetz AD; Bachvarova RF; Besmer P. 1995. The Wsh and Ph mutations affect the c-kit expression profile: c-kit misexpression in embryogenesis impairs melanogenesis in Wsh and Ph mutant mice. Proc Natl Acad Sci U S A 92(9):3754-8. [PubMed: 7537375]  [MGI Ref ID J:25082]

Morrison-Graham K; Schatteman GC; Bork T; Bowen-Pope DF; Weston JA. 1992. A PDGF receptor mutation in the mouse (Patch) perturbs the development of a non-neuronal subset of neural crest-derived cells. Development 115(1):133-42. [PubMed: 1638976]  [MGI Ref ID J:1107]

Orr-Urtreger A; Bedford MT; Do MS; Eisenbach L; Lonai P. 1992. Developmental expression of the alpha receptor for platelet-derived growth factor, which is deleted in the embryonic lethal Patch mutation. Development 115(1):289-303. [PubMed: 1322271]  [MGI Ref ID J:1104]

Schatteman GC; Morrison-Graham K; van Koppen A; Weston JA; Bowen-Pope DF. 1992. Regulation and role of PDGF receptor alpha-subunit expression during embryogenesis. Development 115(1):123-31. [PubMed: 1322269]  [MGI Ref ID J:1108]

Stephenson DA; Mercola M; Anderson E; Wang CY; Stiles CD; Bowen-Pope DF; Chapman VM. 1991. Platelet-derived growth factor receptor alpha-subunit gene (Pdgfra) is deleted in the mouse patch (Ph) mutation. Proc Natl Acad Sci U S A 88(1):6-10. [PubMed: 1846043]  [MGI Ref ID J:10920]

Ph related

Asher JH Jr; Friedman TB. 1990. Mouse and hamster mutants as models for Waardenburg syndromes in humans. J Med Genet 27(10):618-26. [PubMed: 2246770]  [MGI Ref ID J:200892]

Berrozpe G; Timokhina I; Yukl S; Tajima Y; Ono M; Zelenetz AD; Besmer P. 1999. The W(sh), W(57), and Ph Kit expression mutations define tissue-specific control elements located between -23 and -154 kb upstream of Kit. Blood 94(8):2658-66. [PubMed: 10515869]  [MGI Ref ID J:109894]

Brunkow ME; Nagle DL; Bernstein A; Bucan M. 1995. A 1.8-Mb YAC contig spanning three members of the receptor tyrosine kinase gene family (Pdgfra, Kit, and Flk1) on mouse chromosome 5. Genomics 25(2):421-32. [PubMed: 7540588]  [MGI Ref ID J:23149]

Center EM; Marcus NM; Wilson DB. 1988. Abnormal development of the notochord and perinotochordal sheath in duplicitas posterior, patch and tail-short mice. Histol Histopathol 3(4):405-12. [PubMed: 2980249]  [MGI Ref ID J:803]

Deol MS. 1970. The relationship between abnormalities of pigmentation and of the inner ear. Proc R Soc Lond B Biol Sci 175(39):201-17. [PubMed: 4392283]  [MGI Ref ID J:125080]

Gruneberg H. 1971. Exocrine glands and the Chievitz organ of some mouse mutants. J Embryol Exp Morphol 25(2):247-61. [PubMed: 5088022]  [MGI Ref ID J:140462]

Gruneberg H; Truslove GM. 1960. Two closely linked genes in the mouse Genet Res 1:69-90.  [MGI Ref ID J:99]

Helwig U; Imai K; Schmahl W; Thomas BE; Varnum DS; Nadeau JH; Balling R. 1995. Interaction between undulated and Patch leads to an extreme form of spina bifida in double-mutant mice. Nat Genet 11(1):60-3. [PubMed: 7550316]  [MGI Ref ID J:28396]

Itoi M; Tsukamoto N; Yoshida H; Amagai T. 2007. Mesenchymal cells are required for functional development of thymic epithelial cells. Int Immunol 19(8):953-64. [PubMed: 17625108]  [MGI Ref ID J:124645]

Johnson DR. 1976. The interfrontal bone and mutant genes in the mouse. J Anat 121(3):507-13. [PubMed: 1018005]  [MGI Ref ID J:5776]

Jordan SA; Jackson IJ. 2000. A late wave of melanoblast differentiation and rostrocaudal migration revealed in patch and rump-white embryos. Mech Dev 92(2):135-43. [PubMed: 10727853]  [MGI Ref ID J:61455]

King DP; Vitaterna MH; Chang AM; Dove WF; Pinto LH; Turek FW ; Takahashi JS. 1997. The mouse Clock mutation behaves as an antimorph and maps within the W19H deletion, distal of Kit. Genetics 146(3):1049-60. [PubMed: 9215907]  [MGI Ref ID J:41383]

Lamoreux ML. 1999. Strain-specific white-spotting patterns in laboratory mice Pigment Cell Res 12(6):383-90. [PubMed: 10614578]  [MGI Ref ID J:106083]

Li L; Schatteman GC; Oppenheim RW; Lei M; Bowen-Pope DF; Houenou LJ. 1996. Altered development of spinal cord in the mouse mutant (Patch) lacking the PDGF receptor alpha-subunit gene. Brain Res Dev Brain Res 96(1-2):204-9. [PubMed: 8922682]  [MGI Ref ID J:36710]

Loutit JF; Cattanach BM. 1983. Haematopoietic role for Patch (Ph) revealed by new W mutant (Wct) in mice. Genet Res 42(1):29-39. [PubMed: 6628990]  [MGI Ref ID J:7216]

Morrison-Graham K; Schatteman GC; Bork T; Bowen-Pope DF; Weston JA. 1992. A PDGF receptor mutation in the mouse (Patch) perturbs the development of a non-neuronal subset of neural crest-derived cells. Development 115(1):133-42. [PubMed: 1638976]  [MGI Ref ID J:1107]

Nadeau JH. 2001. Modifier genes in mice and humans. Nat Rev Genet 2(3):165-74. [PubMed: 11256068]  [MGI Ref ID J:88013]

Ogura Y; Takakura N; Yoshida H; Nishikawa SI. 1998. Essential role of platelet-derived growth factor receptor alpha in the development of the intraplacental yolk sac/sinus of Duval in mouse placenta. Biol Reprod 58(1):65-72. [PubMed: 9472924]  [MGI Ref ID J:44830]

Orr-Urtreger A; Bedford MT; Do MS; Eisenbach L; Lonai P. 1992. Developmental expression of the alpha receptor for platelet-derived growth factor, which is deleted in the embryonic lethal Patch mutation. Development 115(1):289-303. [PubMed: 1322271]  [MGI Ref ID J:1104]

Payne J; Shibasaki F; Mercola M. 1997. Spina bifida occulta in homozygous Patch mouse embryos. Dev Dyn 209(1):105-16. [PubMed: 9142500]  [MGI Ref ID J:40047]

Robbins JR; McGuire PG; Wehrle-Haller B; Rogers SL. 1999. Diminished matrix metalloproteinase 2 (MMP-2) in ectomesenchyme-derived tissues of the Patch mutant mouse: regulation of MMP-2 by PDGF and effects on mesenchymal cell migration. Dev Biol 212(2):255-63. [PubMed: 10433819]  [MGI Ref ID J:56936]

Schatteman GC; Morrison-Graham K; van Koppen A; Weston JA; Bowen-Pope DF. 1992. Regulation and role of PDGF receptor alpha-subunit expression during embryogenesis. Development 115(1):123-31. [PubMed: 1322269]  [MGI Ref ID J:1108]

Schatteman GC; Motley ST; Effmann EL; Bowen-Pope DF. 1995. Platelet-derived growth factor receptor alpha subunit deleted Patch mouse exhibits severe cardiovascular dysmorphogenesis. Teratology 51(6):351-66. [PubMed: 7502236]  [MGI Ref ID J:28443]

Silvers WK. 1979. The Coat Colors of Mice; A Model for Mammalian Gene Action and Interaction. In: The Coat Colors of Mice. Springer-Verlag, New York.  [MGI Ref ID J:78801]

Smith EA; Seldin MF; Martinez L; Watson ML; Choudhury GG; Lalley PA; Pierce J; Aaronson S; Barker J; Naylor SL; Sakaguchi AY. 1991. Mouse platelet-derived growth factor receptor alpha gene is deleted in W19H and patch mutations on chromosome 5. Proc Natl Acad Sci U S A 88(11):4811-5. [PubMed: 1647018]  [MGI Ref ID J:11255]

Stephenson DA; Mercola M; Anderson E; Wang CY; Stiles CD; Bowen-Pope DF; Chapman VM. 1991. Platelet-derived growth factor receptor alpha-subunit gene (Pdgfra) is deleted in the mouse patch (Ph) mutation. Proc Natl Acad Sci U S A 88(1):6-10. [PubMed: 1846043]  [MGI Ref ID J:10920]

Sun T; Jayatilake D; Afink GB; Ataliotis P; Nister M; Richardson WD; Smith HK. 2000. A human YAC transgene rescues craniofacial and neural tube development in PDGFRalpha knockout mice and uncovers a role for PDGFRalpha in prenatal lung growth. Development 127(21):4519-29. [PubMed: 11023856]  [MGI Ref ID J:64680]

Wehrle-Haller B; Morrison-Graham K; Weston JA. 1996. Ectopic c-kit expression affects the fate of melanocyte precursors in Patch mutant embryos. Dev Biol 177(2):463-74. [PubMed: 8806824]  [MGI Ref ID J:34586]

Zhao S; Overbeek PA. 1999. Tyrosinase-related protein 2 promoter targets transgene expression to ocular and neural crest-derived tissues. Dev Biol 216(1):154-63. [PubMed: 10588869]  [MGI Ref ID J:134392]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Colony Maintenance

Diet Information LabDiet® 5K52/5K67

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $3300.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $4290.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Control Information

  Control
   000664 C57BL/6J
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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