Strain Name:

C57BL/6J-KitW-41J/J

Stock Number:

000119

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Availability:

Cryopreserved - Ready for recovery

Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Former Names C57BL/6J-KitW-41J    (Changed: 27-NOV-06 )
Type Coisogenic; Mutant Strain;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Specieslaboratory mouse

Appearance
black with white belly spot (variable spot size), pale feet due to anemia
Related Genotype: a/a KitW-41J/+

mostly white with brown or grey spots, black eyes
Related Genotype: a/a KitW-41J/KitW-41J

black
Related Genotype: a/a +/+

Control Information

  Control
   See control note: Because wildtype mice are distinguished from heterozygotes via phenotypic expression which may be variable in expressivity (not all heterozygotes have a visible white belly spot although lightened feet and tail are usually seen), C57BL/6J may be a more certain control than wildtype.
   Wild-type from the colony
   000664 C57BL/6J
 
  Considerations for Choosing Controls

Related Strains

Strains carrying   KitW-41J allele
006564   B6(C)-KitW-41J Gusbmps/BrkJ
View Strains carrying   KitW-41J     (1 strain)

View Strains carrying other alleles of Kit     (38 strains)

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested.
Gastrointestinal Stromal Tumor; GIST   (KIT)
Mast Cell Disease   (KIT)
Piebald Trait; PBT   (KIT)
Testicular Germ Cell Tumor; TGCT   (KIT)
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

KitW-41J/Kit+

        involves: C57BL/6J
  • hematopoietic system phenotype
  • macrocytic anemia
    • mild, normochromic, macrocytic anemia   (MGI Ref ID J:6571)
  • pigmentation phenotype
  • belly spot
    • mice exhibit small white belly spots   (MGI Ref ID J:6571)
  • diluted coat color
    • mice exhibit slight dilution of their dorsal and ventral coats   (MGI Ref ID J:6571)
  • integument phenotype
  • belly spot
    • mice exhibit small white belly spots   (MGI Ref ID J:6571)
  • diluted coat color
    • mice exhibit slight dilution of their dorsal and ventral coats   (MGI Ref ID J:6571)

KitW-41J/KitW-41J

        involves: C57BL/6J
  • reproductive system phenotype
  • *normal* reproductive system phenotype
    • mice are fertile   (MGI Ref ID J:6571)
    • abnormal ovarian follicle number
      • ovaries contain fewer developing follicles than in wild-type mice   (MGI Ref ID J:6571)
    • small ovary   (MGI Ref ID J:6571)
  • hematopoietic system phenotype
  • macrocytic anemia
    • mild, normochromic, macrocytic anemia   (MGI Ref ID J:6571)
  • endocrine/exocrine gland phenotype
  • abnormal ovarian follicle number
    • ovaries contain fewer developing follicles than in wild-type mice   (MGI Ref ID J:6571)
  • small ovary   (MGI Ref ID J:6571)
  • pigmentation phenotype
  • irregular coat pigmentation
    • mice exhibit a black-flecked white coat in which the dorsal coat has concentrated areas of black about the head and hind quarters and the ventral coat is white with black hair along lateral borders   (MGI Ref ID J:6571)
  • integument phenotype
  • irregular coat pigmentation
    • mice exhibit a black-flecked white coat in which the dorsal coat has concentrated areas of black about the head and hind quarters and the ventral coat is white with black hair along lateral borders   (MGI Ref ID J:6571)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

KitW-41J related

Cancer Research
Growth Factors/Receptors/Cytokines
Increased Tumor Incidence
      Gonadal Tumors
      Gonadal Tumors: ovarian
Oncogenes

Dermatology Research
Color and White Spotting Defects

Developmental Biology Research
Neural Crest Defects

Endocrine Deficiency Research
Bone/Bone Marrow Defects
Gonad Defects
Skin Defects

Immunology, Inflammation and Autoimmunity Research
Immunodeficiency

Neurobiology Research
Hearing Defects
Receptor Defects

Reproductive Biology Research
Developmental Defects Affecting Gonads
      germ cell deficient
Fertility Defects
Gonadal Tumors
      ovarian

Research Tools
Immunology, Inflammation and Autoimmunity Research
      Mast Cell Deficiency

Sensorineural Research
Hearing Defects

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol KitW-41J
Allele Name dominant spotting 41 Jackson
Allele Type Spontaneous
Common Name(s) KitW41; W-41; W41;
Strain of OriginC57BL/6J
Gene Symbol and Name Kit, kit oncogene
Chromosome 5
Gene Common Name(s) Bs; C-Kit; CD117; Dominant white spotting; Fdc; Gsfsco1; Gsfsco5; Gsfsow3; PBT; SCFR; SCO1; SCO5; SOW3; Ssm; Steel Factor Receptor; Tr-kit; W; belly-spot; dominant spotting; gsf spotted coat 1; gsf spotted coat 5; phenotype like Sl or W 3; spotted sterile male;
Molecular Note Comparison of the coding sequence of this allele with normal c-kit indicated a G to A point mutation in the kinase domain at nucleotide 2519 that results in a valine to methionine substitution at amino acid 831. [MGI Ref ID J:10528]

Genotyping

Genotyping Information


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Additional References

KitW-41J related

Benveniste P; Frelin C; Janmohamed S; Barbara M; Herrington R; Hyam D; Iscove NN. 2010. Intermediate-term hematopoietic stem cells with extended but time-limited reconstitution potential. Cell Stem Cell 6(1):48-58. [PubMed: 20074534]  [MGI Ref ID J:157080]

Benz C; Copley MR; Kent DG; Wohrer S; Cortes A; Aghaeepour N; Ma E; Mader H; Rowe K; Day C; Treloar D; Brinkman RR; Eaves CJ. 2012. Hematopoietic stem cell subtypes expand differentially during development and display distinct lymphopoietic programs. Cell Stem Cell 10(3):273-83. [PubMed: 22385655]  [MGI Ref ID J:185670]

Bowie MB; Kent DG; Copley MR; Eaves CJ. 2007. Steel factor responsiveness regulates the high self-renewal phenotype of fetal hematopoietic stem cells. Blood 109(11):5043-8. [PubMed: 17327414]  [MGI Ref ID J:145423]

Bowie MB; McKnight KD; Kent DG; McCaffrey L; Hoodless PA; Eaves CJ. 2006. Hematopoietic stem cells proliferate until after birth and show a reversible phase-specific engraftment defect. J Clin Invest 116(10):2808-16. [PubMed: 17016561]  [MGI Ref ID J:114978]

Cable J; Huszar D; Jaenisch R; Steel KP. 1994. Effects of mutations at the W locus (c-kit) on inner ear pigmentation and function in the mouse. Pigment Cell Res 7(1):17-32. [PubMed: 7521050]  [MGI Ref ID J:21178]

Cable J; Jackson IJ; Steel KP. 1995. Mutations at the W locus affect survival of neural crest-derived melanocytes in the mouse. Mech Dev 50(2-3):139-50. [PubMed: 7619726]  [MGI Ref ID J:24351]

Chen S; Burgin S; McDaniel A; Li X; Yuan J; Chen M; Khalaf W; Clapp DW; Yang FC. 2010. Nf1-/- Schwann cell-conditioned medium modulates mast cell degranulation by c-Kit-mediated hyperactivation of phosphatidylinositol 3-kinase. Am J Pathol 177(6):3125-32. [PubMed: 21037083]  [MGI Ref ID J:167633]

D'Ascenzo M; Meacham C; Kitzman J; Middle C; Knight J; Winer R; Kukricar M; Richmond T; Albert TJ; Czechanski A; Donahue LR; Affourtit J; Jeddeloh JA; Reinholdt L. 2009. Mutation discovery in the mouse using genetically guided array capture and resequencing. Mamm Genome 20(7):424-36. [PubMed: 19629596]  [MGI Ref ID J:151778]

Diwakar G; Zhang D; Jiang S; Hornyak TJ. 2008. Neurofibromin as a regulator of melanocyte development and differentiation. J Cell Sci 121(Pt 2):167-77. [PubMed: 18089649]  [MGI Ref ID J:130856]

Dykstra B; Kent D; Bowie M; McCaffrey L; Hamilton M; Lyons K; Lee SJ; Brinkman R; Eaves C. 2007. Long-term propagation of distinct hematopoietic differentiation programs in vivo. Cell Stem Cell 1(2):218-29. [PubMed: 18371352]  [MGI Ref ID J:149712]

Dykstra B; Olthof S; Schreuder J; Ritsema M; de Haan G. 2011. Clonal analysis reveals multiple functional defects of aged murine hematopoietic stem cells. J Exp Med 208(13):2691-703. [PubMed: 22110168]  [MGI Ref ID J:179054]

Geissler EN; McFarland EC; Russell ES. 1981. Analysis of pleiotropism at the dominant white-spotting (W) locus of the house mouse: a description of ten new W alleles. Genetics 97(2):337-61. [PubMed: 7274658]  [MGI Ref ID J:6571]

Heuser M; Park G; Moon Y; Berg T; Xiang P; Kuchenbauer F; Vollett S; Lai C; Humphries RK. 2010. Extrinsic signals determine myeloid-erythroid lineage switch in MN1 leukemia. Exp Hematol 38(3):174-9. [PubMed: 20096329]  [MGI Ref ID J:158349]

Ingram DA; Yang FC; Travers JB; Wenning MJ; Hiatt K; New S; Hood A; Shannon K; Williams DA; Clapp DW. 2000. Genetic and biochemical evidence that haploinsufficiency of the Nf1 tumor suppressor gene modulates melanocyte and mast cell fates in vivo. J Exp Med 191(1):181-8. [PubMed: 10620616]  [MGI Ref ID J:59248]

Lacombe J; Krosl G; Tremblay M; Gerby B; Martin R; Aplan PD; Lemieux S; Hoang T. 2013. Genetic interaction between Kit and Scl. Blood 122(7):1150-61. [PubMed: 23836559]  [MGI Ref ID J:202245]

Nocka K; Tan JC; Chiu E; Chu TY; Ray P; Traktman P; Besmer P. 1990. Molecular bases of dominant negative and loss of function mutations at the murine c-kit/white spotting locus: W37, Wv, W41 and W. EMBO J 9(6):1805-13. [PubMed: 1693331]  [MGI Ref ID J:10528]

Reith AD; Rottapel R; Giddens E; Brady C; Forrester L; Bernstein A. 1990. W mutant mice with mild or severe developmental defects contain distinct point mutations in the kinase domain of the c-kit receptor. Genes Dev 4(3):390-400. [PubMed: 1692559]  [MGI Ref ID J:28221]

Sharma Y; Astle CM; Harrison DE. 2007. Heterozygous kit mutants with little or no apparent anemia exhibit large defects in overall hematopoietic stem cell function. Exp Hematol 35(2):214-220. [PubMed: 17258070]  [MGI Ref ID J:123190]

Silvers WK. 1979. The Coat Colors of Mice; A Model for Mammalian Gene Action and Interaction. In: The Coat Colors of Mice. Springer-Verlag, New York.  [MGI Ref ID J:78801]

Soper BW; Duffy TM; Vogler CA; Barker JE. 1999. A genetically myeloablated MPS VII model detects the expansion and curative properties of as few as 100 enriched murine stem cells. Exp Hematol 27(11):1691-704. [PubMed: 10560917]  [MGI Ref ID J:58272]

Thoren LA; Liuba K; Bryder D; Nygren JM; Jensen CT; Qian H; Antonchuk J; Jacobsen SE. 2008. Kit regulates maintenance of quiescent hematopoietic stem cells. J Immunol 180(4):2045-53. [PubMed: 18250409]  [MGI Ref ID J:131940]

Ye L; Zhang EY; Xiong Q; Astle CM; Zhang P; Li Q; From AH; Harrison DE; Zhang JJ. 2012. Aging Kit mutant mice develop cardiomyopathy. PLoS One 7(3):e33407. [PubMed: 22428044]  [MGI Ref ID J:187053]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $2085.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.
    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 11 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice
    Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $2710.50
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.
    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 11 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice
    Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Control Information

  Control
   See control note: Because wildtype mice are distinguished from heterozygotes via phenotypic expression which may be variable in expressivity (not all heterozygotes have a visible white belly spot although lightened feet and tail are usually seen), C57BL/6J may be a more certain control than wildtype.
   Wild-type from the colony
   000664 C57BL/6J
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

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