Strain Name:

B6.Cg-KitlSl Krt71Ca/J

Stock Number:

000124

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Availability:

Cryopreserved - Ready for recovery

Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Former Names B6.Cg-KitlSl Krt2-6gCa/J    (Changed: 21-JUL-06 )
B6.Cg-KitlSl Ca/J    (Changed: 15-DEC-04 )
MgfSl    (Changed: 15-DEC-04 )
Type Congenic; Mutant Strain;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Additional information on Congenic nomenclature.
Specieslaboratory mouse
Background Strain C57BL/6By
Donor Strain KitlSl, C3H; Krt2-6gCa, Swiss mice
GenerationN26F6N2p
Generation Definitions

Description
The multiple steel mutations (KitlSl) behave in a semidominant fashion and cause deficiencies in pigment cells, germ cells, and blood cells paralleling those caused by the Kit locus mutations (dominant spotting alleles). Most of the alleles at steel locus cause severe anemia in utero and death by 15 to 16 days of gestation in homozygous mutant mice. However, compounds of two steel mutants (e.g. KitlSl/KitlSl-d are viable, black-eyed white, are usually sterile in one or both sexes, and have severe macrocytic anemia. Heterozygous steel mice have a diluted coat color with a small amount of white spotting, are viable and fertile, and may have a slight macrocytic anemia. Primordial germ cells are absent in the nonviable steel homozygotes and severely reduced in steel heterozygotes. Mast cells are virtually absent in skin and other tissues of steel mutant mice. Tumors tend to develop in germ-cell-deficient ovaries with advancing age.

In an attempt to offer alleles on well-characterized or multiple genetic backgrounds, alleles are frequently moved to a genetic background different from that on which an allele was first characterized. This is the case for the strain above. It should be noted that the phenotype could vary from that originally described.We will modify the strain description if necessary as published results become available.

Control Information

  Control
   Wild-type from the colony
   001139 C57BL/6ByJ
 
  Considerations for Choosing Controls

Related Strains

Strains carrying   KitlSl allele
000291   C3FeLe.Cg-a/a Hm KitlSl Krt71Ca-J/J
000693   WC/ReJ KitlSl/J
View Strains carrying   KitlSl     (2 strains)

Strains carrying   Krt71Ca allele
000304   B6C3Fe a/a-Krt71Ca Scn8amed-J/J
View Strains carrying   Krt71Ca     (1 strain)

Strains carrying other alleles of Kitl
000090   129S1/Sv-Oca2+ Tyr+ KitlSl-J/J
002993   B6.Cg-KitlSl-18H/EiJ
008656   B6.Cg-KitlSl-gb/MbeJ
009687   B6.Cg-Tg(KRT14-Kitl*)4XTG2Bjl/J
000160   B6.D2-KitlSl-d/J
014608   B6;129S1-a Kitlsl-24J/GrsrJ
001380   C3Sn.Cg-KitlSl-con/J
003252   C57BL/6J-KitlSl-20J/J
000979   STOCK KitlSl-16J/J
017860   STOCK Kitltm1.1Sjm/J
017861   STOCK Kitltm2.1Sjm/J
000161   WB.D2-KitlSl-d/J
001145   WSB/EiJ
View Strains carrying other alleles of Kitl     (13 strains)

Strains carrying other alleles of Krt71
001274   BALB/c-Krt71Ca-9J/J
001755   BALB/cBy-Krt71Ca-10J/J
000291   C3FeLe.Cg-a/a Hm KitlSl Krt71Ca-J/J
022312   NOD/ShiLtJ-Krt71Ca-18J/GrsrJ
View Strains carrying other alleles of Krt71     (4 strains)

Additional Web Information

JAX® NOTES, February 2001; 481. Mgf Gene Name Changes to Kitl.

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested.
Hyperpigmentation, Familial Progressive, 2; FPH2   (KITLG)
Hypotrichosis 13; HYPT13   (KRT71)
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

KitlSl/Kitl+

        involves: C3H
  • pigmentation phenotype
  • abnormal skin pigmentation
    • mice have light ears   (MGI Ref ID J:3399)
    • abnormal ear pigmentation
      • mice have light feet   (MGI Ref ID J:3399)
  • belly spot   (MGI Ref ID J:157170)
    • most mice have a white spot on the belly   (MGI Ref ID J:3399)
  • diluted coat color
    • affected mice have overall dilution of coat color, more extreme on the belly than back   (MGI Ref ID J:3399)
    • reduced coat color   (MGI Ref ID J:157170)
  • head blaze
    • very occasionally mice have a white blaze between their eyes   (MGI Ref ID J:3399)
  • head spot
    • most mice have a white spot on the belly   (MGI Ref ID J:3399)
  • hematopoietic system phenotype
  • anemia
    • mice display less severe anemia than homozygotes   (MGI Ref ID J:3399)
  • decreased erythrocyte cell number
    • at 7-13 days of age, red blood cell counts are 20-30% lower than wild-type   (MGI Ref ID J:3399)
  • hearing/vestibular/ear phenotype
  • abnormal ear pigmentation
    • mice have light feet   (MGI Ref ID J:3399)
  • reproductive system phenotype
  • *normal* reproductive system phenotype
    • heterozygotes are viable and fertile   (MGI Ref ID J:3399)
  • craniofacial phenotype
  • abnormal ear pigmentation
    • mice have light feet   (MGI Ref ID J:3399)
  • integument phenotype
  • abnormal skin pigmentation
    • mice have light ears   (MGI Ref ID J:3399)
    • abnormal ear pigmentation
      • mice have light feet   (MGI Ref ID J:3399)
  • abnormal vibrissa morphology
    • mice have light whiskers   (MGI Ref ID J:3399)
  • belly spot   (MGI Ref ID J:157170)
    • most mice have a white spot on the belly   (MGI Ref ID J:3399)
  • diluted coat color
    • affected mice have overall dilution of coat color, more extreme on the belly than back   (MGI Ref ID J:3399)
    • reduced coat color   (MGI Ref ID J:157170)
  • head blaze
    • very occasionally mice have a white blaze between their eyes   (MGI Ref ID J:3399)
  • head spot
    • most mice have a white spot on the belly   (MGI Ref ID J:3399)
  • pallor
    • some pups after birth are pale compared to littermates   (MGI Ref ID J:3399)
  • growth/size/body phenotype
  • abnormal ear pigmentation
    • mice have light feet   (MGI Ref ID J:3399)

KitlSl/Kitl+

        either: (involves: C3H * WC) or (involves: C3H * C57BL/6 * DBA/2J * WC)
  • hematopoietic system phenotype
  • anemia
    • mice are slightly anemic   (MGI Ref ID J:6084)
  • decreased mast cell number
    • heterozygotes have decreased mast cell numbers in dorsal skin compared to wild-type   (MGI Ref ID J:6084)
  • immune system phenotype
  • decreased mast cell number
    • heterozygotes have decreased mast cell numbers in dorsal skin compared to wild-type   (MGI Ref ID J:6084)

KitlSl/Kitl+

        involves: 129/Sv * C3H
  • tumorigenesis
  • increased tumor incidence
    • male mice develop ~2-fold more tumors than controls   (MGI Ref ID J:50508)
    • increased testicular teratoma incidence
      • incidence is 6.92% compared to ~2.6% in controls   (MGI Ref ID J:50508)
      • tumors are predominantly in left testis (71%) vs right (27%) or bilateral (2%)   (MGI Ref ID J:50508)
      • percentage is greater in second and subsequent litters compared to first litter or in first litter of older females compared to young mothers   (MGI Ref ID J:50508)

KitlSl/KitlSl

        involves: C3H
  • mortality/aging
  • complete lethality throughout fetal growth and development
    • no presumed homozygotes are born; homozygotes begin to die at ~E15-15.5 from anemia   (MGI Ref ID J:3399)
    • an occasional mutant survives until birth   (MGI Ref ID J:3399)
  • nervous system phenotype
  • abnormal brain development
    • at E10.5-12.5, small number of embryos, presumably homozygous, have brain abnormalities, including a collapsed brain, pseudoencephaly or a narrowed brain region   (MGI Ref ID J:3399)
    • from E14.5-17.5, some embryos show abnormal brain development (3/330) as described in younger embryos   (MGI Ref ID J:3399)
    • myelencephalic blebs
      • one E17.5 embryo displayed a bleb near the midline in the cervical region   (MGI Ref ID J:3399)
  • spina bifida
    • 4/330 embryos aged E14.5-17.5 displayed spina bifida   (MGI Ref ID J:3399)
  • hematopoietic system phenotype
  • anemia
    • starting around E13.5 and peaking at E14.5, presumed homozygotes display anemia recognized by overall paleness of the embryos   (MGI Ref ID J:3399)
  • cardiovascular system phenotype
  • abnormal blood circulation
    • in affected (anemic) animals, individual clumps or red blood cells can be seen in umbilical vessels; in controls, vessels are uniformly red with normal blood flow   (MGI Ref ID J:3399)
  • reproductive system phenotype
  • infertility
    • mice carrying two mutant alleles are sterile   (MGI Ref ID J:5547)
  • pigmentation phenotype
  • absent skin pigmentation
    • transplantation of skin grafts from E14, E15 and newborn mutants to normal siblings produced unpigmented hair   (MGI Ref ID J:28098)
  • embryogenesis phenotype
  • spina bifida
    • 4/330 embryos aged E14.5-17.5 displayed spina bifida   (MGI Ref ID J:3399)
  • integument phenotype
  • absent skin pigmentation
    • transplantation of skin grafts from E14, E15 and newborn mutants to normal siblings produced unpigmented hair   (MGI Ref ID J:28098)
  • pallor
    • characteristic of anemic embryos   (MGI Ref ID J:3399)

Krt71Ca/Krt71+

        Background Not Specified
  • integument phenotype
  • curly vibrissae
    • curved and irregular in direction   (MGI Ref ID J:13054)
  • waved hair
    • more marked in the first pelage   (MGI Ref ID J:13054)

Krt71Ca/Krt71Ca

        Background Not Specified
  • integument phenotype
  • curly vibrissae
    • curved and irregular in direction   (MGI Ref ID J:13054)
  • waved hair
    • more marked in the first pelage   (MGI Ref ID J:13054)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

KitlSl related

Cancer Research
Growth Factors/Receptors/Cytokines
Increased Tumor Incidence
      Gonadal Tumors
      Gonadal Tumors: ovarian and testicular

Dermatology Research
Color and White Spotting Defects

Developmental Biology Research
Neural Crest Defects

Endocrine Deficiency Research
Bone/Bone Marrow Defects
Gonad Defects
Hypothalamus/Pituitary Defects
Skin Defects

Immunology, Inflammation and Autoimmunity Research
Growth Factors/Receptors/Cytokines
Immunodeficiency
      Mast Cell Deficiency

Neurobiology Research
Hearing Defects

Reproductive Biology Research
Developmental Defects Affecting Gonads
      germ cell deficient
Fertility Defects
Gonadal Tumors
      ovarian and testicular

Research Tools
Immunology, Inflammation and Autoimmunity Research
      Mast Cell Deficiency

Sensorineural Research
Hearing Defects

Krt71Ca related

Dermatology Research
Skin and Hair Texture Defects

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol KitlSl
Allele Name steel
Allele Type Spontaneous
Common Name(s) MgfSl; Sl;
Strain of OriginC3H
Gene Symbol and Name Kitl, kit ligand
Chromosome 10
Gene Common Name(s) Clo; Con; FPH2; Gb; KL-1; MGF; Mgf; SCF; SF; SHEP7; SLF; Sl; Steel; Steel factor; blaze; blz; cloud gray; contrasted; grizzle-belly; mast cell growth factor; steel; stem cell factor;
Molecular Note By Southern blotting, it was concluded that this allele contains a deletion encompassing most, if not all, of the coding region of the gene. A probe corresponding to nucleotides 6 to 685 of the cDNA failed to hybridize to DNA obtained from embryos homozygous for this allele. PCR analysis with primers for sequences at various distances from the Kit gene narrowed the 5' and 3' deletion endpoints to a 350 and a 380 base-pair region, respectively. Sequencing of the product of PCR using primers designed to span the deletion revealed that it extends through 973,366 base pairs on Chromosome 10 between nucleotide positions 99,177,807 and 100,151,173 (NCBI Map Viewer, Build 36.1), with a 4-base pair insertion joining the deletion endpoints, and contains 6 predicted and 3 known genes. [MGI Ref ID J:10750] [MGI Ref ID J:115283]
 
Allele Symbol Krt71Ca
Allele Name caracul
Allele Type Spontaneous
Common Name(s) Ca;
Strain of OriginSwiss stock
Gene Symbol and Name Krt71, keratin 71
Chromosome 15
Gene Common Name(s) AA589543; Ca; Cal4; Cu; HYPT13; K6IRS1; KRT6IRS; KRT6IRS1; Krt2-6g; caracul; caracul-like 4; curly; expressed sequence AA589543; keratin complex 2, basic, gene 6g; mK6irs; mK6irs1;
Molecular Note Sequence analysis of Krt2-6g identified the transversion of an adenosine to a cytosine at nucleotide 1292, resulting in an alanine to aspartic acid missense mutation at codon 431 (A431D).

Genotyping

Genotyping Information


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Additional References

Arguello F; Furlanetto RW; Baggs RB; Graves BT; Harwell SE; Cohen HJ; Frantz CN. 1992. Incidence and distribution of experimental metastases in mutant mice with defective organ microenvironments (genotypes Sl/Sld and W/Wv). Cancer Res 52(8):2304-9. [PubMed: 1559233]  [MGI Ref ID J:468]

Hayashi C; Sonoda T; Nakano T; Nakayama H; Kitamura Y. 1985. Mast-cell precursors in the skin of mouse embryos and their deficiency in embryos of Sl/Sld genotype. Dev Biol 109(1):234-41. [PubMed: 3987963]  [MGI Ref ID J:7810]

Huang E; Nocka K; Beier DR; Chu TY; Buck J; Lahm HW; Wellner D; Leder P; Besmer P. 1990. The hematopoietic growth factor KL is encoded by the Sl locus and is the ligand of the c-kit receptor, the gene product of the W locus. Cell 63(1):225-33. [PubMed: 1698557]  [MGI Ref ID J:10751]

Kikkawa Y; Oyama A; Ishii R; Miura I; Amano T; Ishii Y; Yoshikawa Y; Masuya H; Wakana S; Shiroishi T; Taya C; Yonekawa H. 2003. A small deletion hotspot in the type II keratin gene mK6irs1/Krt2-6g on mouse chromosome 15, a candidate for causing the wavy hair of the caracul (Ca) mutation. Genetics 165(2):721-33. [PubMed: 14573483]  [MGI Ref ID J:86407]

Murphy ED. 1977. Effects of mutant steel alleles on leukemogenesis and life-span in the mouse. J Natl Cancer Inst 58(1):107-10. [PubMed: 319242]  [MGI Ref ID J:5758]

Schrott A; Egg G; Spoendlin H. 1988. Intermediate filaments in the cochleas of normal and mutant (w/wv, sl/sld) mice. Arch Otorhinolaryngol 245(4):250-4. [PubMed: 2460075]  [MGI Ref ID J:9423]

Schrott A; Spoendlin H. 1987. Pigment anomaly-associated inner ear deafness. Acta Otolaryngol (Stockh) 103(5-6):451-7. [PubMed: 3618172]  [MGI Ref ID J:8813]

Wolf NS. 1978. Dissecting the hematopoietic microenvironment. II. The kinetics of the erythron of the S1/S1d mouse and the dual nature of its anemia. Cell Tissue Kinet 11(4):325-34. [PubMed: 688326]  [MGI Ref ID J:6031]

Zsebo KM; Williams DA; Geissler EN; Broudy VC; Martin FH; Atkins HL; Hsu RY; Birkett NC; Okino KH; Murdock DC; Jacobsen FW; Langley KE; Smith KA; Takeishi T; Cattanach BM; Galli SJ; Suggs SV. 1990. Stem cell factor is encoded at the Sl locus of the mouse and is the ligand for the c-kit tyrosine kinase receptor. Cell 63(1):213-24. [PubMed: 1698556]  [MGI Ref ID J:10750]

KitlSl related

Bennett D. 1956. Developmental analysis of a mutation with pleiotropic effects in the mouse J Morphol 98(2):199-233.  [MGI Ref ID J:28098]

Bernstein SE. 1969. Hereditary disorders of the rodent erythron. In: Genetics in Laboratory Animal Medicine. Natl Acad Sci Publ, Washington, DC.  [MGI Ref ID J:30699]

Chan CK; Chen CC; Luppen CA; Kim JB; DeBoer AT; Wei K; Helms JA; Kuo CJ; Kraft DL; Weissman IL. 2009. Endochondral ossification is required for haematopoietic stem-cell niche formation. Nature 457(7228):490-4. [PubMed: 19078959]  [MGI Ref ID J:143892]

Chen L; Faire M; Kissner MD; Laird DJ. 2013. Primordial germ cells and gastrointestinal stromal tumors respond distinctly to a cKit overactivating allele. Hum Mol Genet 22(2):313-27. [PubMed: 23077213]  [MGI Ref ID J:191131]

Chen R; Ning G; Zhao ML; Fleming MG; Diaz LA; Werb Z; Liu Z. 2001. Mast cells play a key role in neutrophil recruitment in experimental bullous pemphigoid. J Clin Invest 108(8):1151-8. [PubMed: 11602622]  [MGI Ref ID J:72195]

Clark EA; Shultz LD; Pollack SB. 1981. Mutations in mice that influence natural killer (NK) cell activity. Immunogenetics 12(5-6):601-13. [PubMed: 6971254]  [MGI Ref ID J:6485]

Copeland NG; Gilbert DJ; Cho BC; Donovan PJ; Jenkins NA; Cosman D; Anderson D; Lyman SD; Williams DE. 1990. Mast cell growth factor maps near the steel locus on mouse chromosome 10 and is deleted in a number of steel alleles. Cell 63(1):175-83. [PubMed: 1698554]  [MGI Ref ID J:10748]

Deshpande S; Agosti V; Manova K; Moore MA; Hardy MP; Besmer P. 2010. Kit ligand cytoplasmic domain is essential for basolateral sorting in vivo and has roles in spermatogenesis and hematopoiesis. Dev Biol 337(2):199-210. [PubMed: 19874813]  [MGI Ref ID J:157170]

Ding H; Nedrud JG; Wershil B; Redline RW; Blanchard TG; Czinn SJ. 2009. Partial protection against Helicobacter pylori in the absence of mast cells in mice. Infect Immun 77(12):5543-50. [PubMed: 19822650]  [MGI Ref ID J:155471]

Flanagan JG; Leder P. 1990. The kit ligand: a cell surface molecule altered in steel mutant fibroblasts. Cell 63(1):185-94. [PubMed: 1698555]  [MGI Ref ID J:10749]

Gore BB; Wong KG; Tessier-Lavigne M. 2008. Stem cell factor functions as an outgrowth-promoting factor to enable axon exit from the midline intermediate target. Neuron 57(4):501-10. [PubMed: 18304480]  [MGI Ref ID J:132880]

Gu Y; Runyan C; Shoemaker A; Surani A; Wylie C. 2009. Steel factor controls primordial germ cell survival and motility from the time of their specification in the allantois, and provides a continuous niche throughout their migration. Development 136(8):1295-303. [PubMed: 19279135]  [MGI Ref ID J:147283]

Gurish MF; Tao H; Abonia JP; Arya A; Friend DS; Parker CM; Austen KF. 2001. Intestinal mast cell progenitors require CD49dbeta7 (alpha4beta7 integrin) for tissue-specific homing. J Exp Med 194(9):1243-52. [PubMed: 11696590]  [MGI Ref ID J:119138]

Hayashi C; Sonoda T; Nakano T; Nakayama H; Kitamura Y. 1985. Mast-cell precursors in the skin of mouse embryos and their deficiency in embryos of Sl/Sld genotype. Dev Biol 109(1):234-41. [PubMed: 3987963]  [MGI Ref ID J:7810]

Hu B; Colletti LM. 2008. Stem cell factor and c-kit are involved in hepatic recovery after acetaminophen-induced liver injury in mice. Am J Physiol Gastrointest Liver Physiol 295(1):G45-G53. [PubMed: 18467506]  [MGI Ref ID J:137545]

Ishii M; Tachiwana T; Hoshino A; Tsunekawa N; Hiramatsu R; Matoba S; Kanai-Azuma M; Kawakami H; Kurohmaru M; Kanai Y. 2007. Potency of testicular somatic environment to support spermatogenesis in XX/Sry transgenic male mice. Development 134(3):449-54. [PubMed: 17185318]  [MGI Ref ID J:135064]

Jones TG; Hallgren J; Humbles A; Burwell T; Finkelman FD; Alcaide P; Austen KF; Gurish MF. 2009. Antigen-induced increases in pulmonary mast cell progenitor numbers depend on IL-9 and CD1d-restricted NKT cells. J Immunol 183(8):5251-60. [PubMed: 19783672]  [MGI Ref ID J:153832]

Kitamura Y; Go S. 1979. Decreased production of mast cells in S1/S1d anemic mice. Blood 53(3):492-7. [PubMed: 367470]  [MGI Ref ID J:6084]

Kitamura Y; Yokoyama M; Matsuda H; Shimada M. 1980. Coincidental development of forestomach papilloma and prepyloric ulcer in nontreated mutant mice of W/Wv and SI/SId genotypes. Cancer Res 40(9):3392-7. [PubMed: 7000343]  [MGI Ref ID J:6393]

Krishnamoorthy N; Oriss TB; Paglia M; Fei M; Yarlagadda M; Vanhaesebroeck B; Ray A; Ray P. 2008. Activation of c-Kit in dendritic cells regulates T helper cell differentiation and allergic asthma. Nat Med 14(5):565-73. [PubMed: 18454155]  [MGI Ref ID J:136704]

Lam MY; Nadeau JH. 2003. Genetic control of susceptibility to spontaneous testicular germ cell tumors in mice. APMIS 111(1):184-90; discussion 191. [PubMed: 12752260]  [MGI Ref ID J:82965]

Lee DM; Friend DS; Gurish MF; Benoist C; Mathis D; Brenner MB. 2002. Mast cells: a cellular link between autoantibodies and inflammatory arthritis. Science 297(5587):1689-92. [PubMed: 12215644]  [MGI Ref ID J:78906]

Lotinun S; Evans GL; Turner RT; Oursler MJ. 2005. Deletion of membrane-bound steel factor results in osteopenia in mice. J Bone Miner Res 20(4):644-52. [PubMed: 15765184]  [MGI Ref ID J:111273]

Lourenssen S; Motro B; Bernstein A; Diamond J. 2000. Defects in sensory nerve numbers and growth in mutant Kit and Steel mice. Neuroreport 11(6):1159-65. [PubMed: 10817584]  [MGI Ref ID J:103680]

Majumdar MK; Everett ET; Xiao X; Cooper R; Langley K; Kapur R; Vik T; Williams DA. 1996. Xenogeneic expression of human stem cell factor in transgenic mice mimics codominant c-kit mutations. Blood 87(8):3203-11. [PubMed: 8605335]  [MGI Ref ID J:32600]

McCoshen JA; McCallion DJ. 1975. A study of the primordial germ cells during their migratory phase in Steel mutant mice. Experientia 31(5):589-90. [PubMed: 1170085]  [MGI Ref ID J:5547]

Mikkelsen HB; Malysz J; Huizinga JD; Thuneberg L. 1998. Action potential generation, Kit receptor immunohistochemistry and morphology of steel-Dickie (Sl/Sld) mutant mouse small intestine. Neurogastroenterol Motil 10(1):11-26. [PubMed: 9507248]  [MGI Ref ID J:113054]

Moro K; Yamada T; Tanabe M; Takeuchi T; Ikawa T; Kawamoto H; Furusawa J; Ohtani M; Fujii H; Koyasu S. 2010. Innate production of T(H)2 cytokines by adipose tissue-associated c-Kit(+)Sca-1(+) lymphoid cells. Nature 463(7280):540-4. [PubMed: 20023630]  [MGI Ref ID J:156764]

Motro B; Wojtowicz JM; Bernstein A; van der Kooy D. 1996. Steel mutant mice are deficient in hippocampal learning but not long-term potentiation. Proc Natl Acad Sci U S A 93(5):1808-13. [PubMed: 8700840]  [MGI Ref ID J:32130]

Murphy ED. 1966. Characteristic Tumors. In: Biology of the Laboratory Mouse. McGraw-Hill, New York.  [MGI Ref ID J:24830]

Murphy ED. 1977. Effects of mutant steel alleles on leukemogenesis and life-span in the mouse. J Natl Cancer Inst 58(1):107-10. [PubMed: 319242]  [MGI Ref ID J:5758]

Ogawa T; Dobrinski I; Avarbock MR; Brinster RL. 2000. Transplantation of male germ line stem cells restores fertility in infertile mice [see comments] Nat Med 6(1):29-34. [PubMed: 10613820]  [MGI Ref ID J:59322]

Ohta H; Aizawa S; Nishimune Y. 2003. Functional Analysis of the p53 Gene in Apoptosis Induced by Heat Stress or Loss of Stem Cell Factor Signaling in Mouse Male Germ Cells. Biol Reprod 68(6):2249-54. [PubMed: 12606380]  [MGI Ref ID J:83572]

Ohta H; Yomogida K; Dohmae K; Nishimune Y. 2000. Regulation of proliferation and differentiation in spermatogonial stem cells: the role of c-kit and its ligand SCF Development 127(10):2125-31. [PubMed: 10769236]  [MGI Ref ID J:61520]

Puddington L; Olson S; Lefrancois L. 1994. Interactions between stem cell factor and c-Kit are required for intestinal immune system homeostasis. Immunity 1(9):733-9. [PubMed: 7534619]  [MGI Ref ID J:189422]

Ren X; Hogaboam C; Carpenter A; Colletti L. 2003. Stem cell factor restores hepatocyte proliferation in IL-6 knockout mice following 70% hepatectomy. J Clin Invest 112(9):1407-18. [PubMed: 14597766]  [MGI Ref ID J:118475]

Rodewald HR; Kretzschmar K; Swat W; Takeda S. 1995. Intrathymically expressed c-kit ligand (stem cell factor) is a major factor driving expansion of very immature thymocytes in vivo. Immunity 3(3):313-9. [PubMed: 7552996]  [MGI Ref ID J:28959]

Runyan C; Schaible K; Molyneaux K; Wang Z; Levin L; Wylie C. 2006. Steel factor controls midline cell death of primordial germ cells and is essential for their normal proliferation and migration. Development 133(24):4861-9. [PubMed: 17107997]  [MGI Ref ID J:115283]

Russell ES. 1970. Abnormalities of erythropoiesis associated with mutant genes in mice. In: Regulation of Hematopoiesis. Appleton-Century-Crofts, New York.  [MGI Ref ID J:27511]

Russell ES; Bernstein SE. 1966. Blood and Blood Formation. In: Biology of the Laboratory Mouse. McGraw Hill, New York.  [MGI Ref ID J:24829]

Russell LB; Russell WL. 1953. Steel (Sl) and Pearl (pe) Mouse News Lett 8:14.  [MGI Ref ID J:104625]

Sarvella PA; Russell LB. 1956. Steel, a new dominant gene in the house mouse J Hered 47:123-128.  [MGI Ref ID J:3399]

Sassa S; Bernstein SE. 1978. Studies of erythrocyte protoporphyrin in anemic mutant mice: use of a modified hematofluorometer for the detection of heterozygotes for hemolytic disease. Exp Hematol 6(5):479-87. [PubMed: 658175]  [MGI Ref ID J:5985]

Sato T; Yokonishi T; Komeya M; Katagiri K; Kubota Y; Matoba S; Ogonuki N; Ogura A; Yoshida S; Ogawa T. 2012. Testis tissue explantation cures spermatogenic failure in c-Kit ligand mutant mice. Proc Natl Acad Sci U S A 109(42):16934-8. [PubMed: 22984182]  [MGI Ref ID J:190116]

Schwarzenberger P; Huang W; Ye P; Oliver P; Manuel M; Zhang Z; Bagby G; Nelson S; Kolls JK. 2000. Requirement of endogenous stem cell factor and granulocyte-colony-stimulating factor for IL-17-mediated granulopoiesis. J Immunol 164(9):4783-9. [PubMed: 10779785]  [MGI Ref ID J:112156]

Silver DL; Hou L; Somerville R; Young ME; Apte SS; Pavan WJ. 2008. The secreted metalloprotease AMAMTS20 is required for melanoblast survival PLoS Genet 4(2):e1000003. [PubMed: 18454205]  [MGI Ref ID J:133403]

Silvers WK. 1979. The Coat Colors of Mice; A Model for Mammalian Gene Action and Interaction. In: The Coat Colors of Mice. Springer-Verlag, New York.  [MGI Ref ID J:78801]

Staats J. 1963. Inbred Strains of Mice No. 3 Companion to Mouse News Lett No. 29 :.  [MGI Ref ID J:55932]

Stevens LC; Mackensen JA. 1961. Genetic and environmental influences on teratocarcinogenesis in mice J Natl Cancer Inst 27:443-453.  [MGI Ref ID J:50508]

Sundberg JP; Kenty GA; Beamer WG; Adkison DL. 1992. Forestomach papillomas in flaky skin and steel-Dickie mutant mice. J Vet Diagn Invest 4(3):312-7. [PubMed: 1325193]  [MGI Ref ID J:2777]

Sweet HO; Davisson MT. 1995. Remutations at The Jackson Laboratory (Update to Mouse Genome 1993; 91:862-5 - J16313) Mouse Genome 93(4):1030-4.  [MGI Ref ID J:30778]

Tadokoro Y; Yomogida K; Ohta H; Tohda A; Nishimune Y. 2002. Homeostatic regulation of germinal stem cell proliferation by the GDNF/FSH pathway. Mech Dev 113(1):29-39. [PubMed: 11900972]  [MGI Ref ID J:184664]

The Jackson Laboratory Office of Genetic Resources. 1983. Registry of Remutation at The Jackson Laboratory, 1983-1984 MGI Direct Data Submission :.  [MGI Ref ID J:79402]

Tokuda M; Kadokawa Y; Kurahashi H; Marunouchi T. 2007. CDH1 is a specific marker for undifferentiated spermatogonia in mouse testes. Biol Reprod 76(1):130-41. [PubMed: 17035642]  [MGI Ref ID J:117360]

Turner RT; Wong CP; Iwaniec UT. 2011. Effect of reduced c-Kit signaling on bone marrow adiposity. Anat Rec (Hoboken) 294(7):1126-34. [PubMed: 21634019]  [MGI Ref ID J:175574]

Turnquist HR; Zhao Z; Rosborough BR; Liu Q; Castellaneta A; Isse K; Wang Z; Lang M; Stolz DB; Zheng XX; Demetris AJ; Liew FY; Wood KJ; Thomson AW. 2011. IL-33 expands suppressive CD11b+ Gr-1 int and regulatory T cells, including ST2L+ Foxp3+ cells, and mediates regulatory T cell-dependent promotion of cardiac allograft survival. J Immunol 187(9):4598-610. [PubMed: 21949025]  [MGI Ref ID J:179437]

Wang CH; Anderson N; Li SH; Szmitko PE; Cherng WJ; Fedak PW; Fazel S; Li RK; Yau TM; Weisel RD; Stanford WL; Verma S. 2006. Stem cell factor deficiency is vasculoprotective: unraveling a new therapeutic potential of imatinib mesylate. Circ Res 99(6):617-25. [PubMed: 16931795]  [MGI Ref ID J:125065]

Watanabe M; Satoh T; Yamamoto Y; Kanai Y; Karasuyama H; Yokozeki H. 2008. Overproduction of IgE induces macrophage-derived chemokine (CCL22) secretion from basophils. J Immunol 181(8):5653-9. [PubMed: 18832724]  [MGI Ref ID J:140755]

Wehrle-Haller B; Weston JA. 1995. Soluble and cell-bound forms of steel factor activity play distinct roles in melanocyte precursor dispersal and survival on the lateral neural crest migration pathway. Development 121(3):731-42. [PubMed: 7536655]  [MGI Ref ID J:40215]

Wershil BK; Castagliuolo I; Pothoulakis C. 1998. Direct evidence of mast cell involvement in Clostridium difficile toxin A-induced enteritis in mice. Gastroenterology 114(5):956-64. [PubMed: 9558284]  [MGI Ref ID J:107762]

Wershil BK; Theodos CM; Galli SJ; Titus RG. 1994. Mast cells augment lesion size and persistence during experimental Leishmania major infection in the mouse. J Immunol 152(9):4563-71. [PubMed: 8157970]  [MGI Ref ID J:17706]

Wolf NS. 1978. Dissecting the hematopoietic microenvironment. II. The kinetics of the erythron of the S1/S1d mouse and the dual nature of its anemia. Cell Tissue Kinet 11(4):325-34. [PubMed: 688326]  [MGI Ref ID J:6031]

Wouters M; De Laet A; Donck LV; Delpire E; van Bogaert PP; Timmermans JP; de Kerchove d'Exaerde A; Smans K; Vanderwinden JM. 2006. Subtractive hybridization unravels a role for the ion cotransporter NKCC1 in the murine intestinal pacemaker. Am J Physiol Gastrointest Liver Physiol 290(6):G1219-27. [PubMed: 16123204]  [MGI Ref ID J:111089]

Zsebo KM; Williams DA; Geissler EN; Broudy VC; Martin FH; Atkins HL; Hsu RY; Birkett NC; Okino KH; Murdock DC; Jacobsen FW; Langley KE; Smith KA; Takeishi T; Cattanach BM; Galli SJ; Suggs SV. 1990. Stem cell factor is encoded at the Sl locus of the mouse and is the ligand for the c-kit tyrosine kinase receptor. Cell 63(1):213-24. [PubMed: 1698556]  [MGI Ref ID J:10750]

Krt71Ca related

Dunn LC. 1937. Caracul, a dominant mutation. J Hered 28:334.  [MGI Ref ID J:13054]

Hogan ME; King LE Jr; Sundberg JP. 1995. Defects of pelage hairs in 20 mouse mutations. J Invest Dermatol 104(5 Suppl):31S-32S. [PubMed: 7738386]  [MGI Ref ID J:25255]

Kikkawa Y; Oyama A; Ishii R; Miura I; Amano T; Ishii Y; Yoshikawa Y; Masuya H; Wakana S; Shiroishi T; Taya C; Yonekawa H. 2003. A small deletion hotspot in the type II keratin gene mK6irs1/Krt2-6g on mouse chromosome 15, a candidate for causing the wavy hair of the caracul (Ca) mutation. Genetics 165(2):721-33. [PubMed: 14573483]  [MGI Ref ID J:86407]

Poirier C; Yoshiki A; Fujiwara K; Guenet JL; Kusakabe M. 2002. Hague (Hag). A new mouse hair mutation with an unstable semidominant allele. Genetics 162(2):831-40. [PubMed: 12399393]  [MGI Ref ID J:79964]

Sundberg JP (ed.). 1994. Handbook of Mouse Mutations with Skin and Hair Abnormalities: Animal Models and Biomedical Tools. In: Handbook of Mouse Mutations with Skin and Hair Abnormalities: Animal Models and Biomedical Tools. CRC Press, Boca Raton.  [MGI Ref ID J:30359]

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Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $3300.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We willfulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $4290.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We willfulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Control Information

  Control
   Wild-type from the colony
   001139 C57BL/6ByJ
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

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Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.


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The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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phone:207-288-6470

JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


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