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- Description
- Disease & phenotype
- Genes & alleles
- Genotyping
- Health & care
- References
- Pricing & purchasing
- Terms of use
Description
The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.
Strain Information
Type Coisogenic; Mutant Strain; Spontaneous Mutation; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Species laboratory mouse Generation N33p
Generation DefinitionsAppearance
mostly white with black eyes, gray ears, and sometimes a black body spot
Related Genotype: a/a KitW-42/+
Control Information
| Control | ||
|---|---|---|
| Wild-type from the colony | ||
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying other alleles of Kit
View Strains carrying other alleles of Kit (38 strains)
Phenotype
Phenotype Information
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested. Gastrointestinal Stromal Tumor; GIST (KIT)
Leukemia, Acute Myeloid; AML (KIT)
Mast Cell Disease (KIT)
Piebald Trait; PBT (KIT)
Testicular Germ Cell Tumor; TGCT (KIT)
assigned by genotype
KitW-42J/Kit+
involves: C57BL/6J
- reproductive system phenotype
- abnormal ovarian follicle number (MGI Ref ID J:6571)
- small testis (MGI Ref ID J:6571)
- pigmentation phenotype
- absent coat pigmentation
- irregular coat pigmentation
- hematopoietic system phenotype
- macrocytic anemia
- mild, normochromic, macrocytic anemia (MGI Ref ID J:6571)
- endocrine/exocrine gland phenotype
- abnormal ovarian follicle number (MGI Ref ID J:6571)
- small testis (MGI Ref ID J:6571)
- integument phenotype
- absent coat pigmentation
- irregular coat pigmentation
KitW-42J/KitW-42J
involves: C57BL/6J
- mortality/aging
- complete perinatal lethality
- die late in gestation or immediately after birth (MGI Ref ID J:6571)
- hematopoietic system phenotype
- macrocytic anemia (MGI Ref ID J:6571)
KitW-42J/KitW-42J
C57BL/6J-KitW-42J
- mortality/aging
- partial embryonic lethality during organogenesis
- at E12.5, sub-Mendelian ratios are recovered (MGI Ref ID J:36829)
- reproductive system phenotype
- *normal* reproductive system phenotype
- testes differentiation is not delayed (MGI Ref ID J:36829)
The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.
KitW-42J/Kit+
involves: C57BL/6 * C57BL/6J * WB
- immune system phenotype
- decreased mast cell number
- mice exhibit fewer mast cells in the skin than wild-type mice (MGI Ref ID J:27513)
- pigmentation phenotype
- diluted coat color (MGI Ref ID J:27513)
- white spotting (MGI Ref ID J:27513)
- hematopoietic system phenotype
- decreased erythrocyte cell number (MGI Ref ID J:27513)
- decreased mast cell number
- mice exhibit fewer mast cells in the skin than wild-type mice (MGI Ref ID J:27513)
- integument phenotype
- diluted coat color (MGI Ref ID J:27513)
- white spotting (MGI Ref ID J:27513)
This mouse can be used to support research in many areas including:KitW-42J related
Cancer Research
Growth Factors/Receptors/Cytokines
Increased Tumor Incidence
Gonadal Tumors
Gonadal Tumors: ovarian
Oncogenes
Dermatology Research
Color and White Spotting Defects
Developmental Biology Research
Neural Crest Defects
Endocrine Deficiency Research
Bone/Bone Marrow Defects
Gonad Defects
Skin Defects
Immunology, Inflammation and Autoimmunity Research
Immunodeficiency
Mast Cell Deficiency
Neurobiology Research
Hearing Defects
Receptor Defects
Reproductive Biology Research
Developmental Defects Affecting Gonads
germ cell deficient
Fertility Defects
Gonadal Tumors
ovarian
Research Tools
Immunology and Inflammation Research
Mast Cell Deficiency
Sensorineural Research
Hearing Defects
Genes & Alleles
Gene & Allele Information provided by MGI
| Allele Symbol | KitW-42J | ||
|---|---|---|---|
| Allele Name | dominant spotting 42 Jackson | ||
| Allele Type | Spontaneous | ||
| Common Name(s) | W-42; We; | ||
| Strain of Origin | C57BL/6J | ||
| Gene Symbol and Name | Kit, kit oncogene | ||
| Chromosome | 5 | ||
| Gene Common Name(s) | Bs; C-Kit; CD117; Dominant white spotting; Fdc; Gsfsco1; Gsfsco5; Gsfsow3; PBT; SCFR; SCO1; SCO5; SOW3; Ssm; Steel Factor Receptor; Tr-kit; W; belly-spot; dominant spotting; gsf spotted coat 1; gsf spotted coat 5; phenotype like Sl or W 3; spotted sterile male; | ||
| Molecular Note | Nucleotide sequence analysis of mutant complementary DNAs revealed a G to A transition (position 2369) resulting in a missense mutation. Kit receptor tyrosine kinase activity is affected but not c-kit encoded proteins. [MGI Ref ID J:10187] | ||
References
References provided by MGI
Additional References
Arguello F; Furlanetto RW; Baggs RB; Graves BT; Harwell SE; Cohen HJ; Frantz CN. 1992. Incidence and distribution of experimental metastases in mutant mice with defective organ microenvironments (genotypes Sl/Sld and W/Wv). Cancer Res 52(8):2304-9. [PubMed: 1559233] [MGI Ref ID J:468]
Kitamura Y; Kasugai T; Ebi Y; Nomura S. 1991. Fibroblast-dependent differentiation/proliferation of mast cells. Skin Pharmacol 4 Suppl 1:2-7. [PubMed: 1764248] [MGI Ref ID J:619]
Murphy ED. 1972. Hyperplastic and early neoplastic changes in the ovaries of mice after genic deletion of germ cells. J Natl Cancer Inst 48(5):1283-95. [PubMed: 4337905] [MGI Ref ID J:5274]
Nocka K; Tan JC; Chiu E; Chu TY; Ray P; Traktman P; Besmer P. 1990. Molecular bases of dominant negative and loss of function mutations at the murine c-kit/white spotting locus: W37, Wv, W41 and W. EMBO J 9(6):1805-13. [PubMed: 1693331] [MGI Ref ID J:10528]
KitW-42J relatedGeissler EN; McFarland EC; Russell ES. 1981. Analysis of pleiotropism at the dominant white-spotting (W) locus of the house mouse: a description of ten new W alleles. Genetics 97(2):337-61. [PubMed: 7274658] [MGI Ref ID J:6571]
Nagamine CM; Capehart J; Carlisle C; Chang D. 1998. Ovotestes in B6-XXSxr sex-reversed mice. Dev Biol 196(1):24-32. [PubMed: 9527878] [MGI Ref ID J:47046]
Nagamine CM; Carlisle C. 1996. The dominant white spotting oncogene allele Kit(W-42J) exacerbates XY(DOM) sex reversal. Development 122(11):3597-605. [PubMed: 8951075] [MGI Ref ID J:36829]
Sharma Y; Astle CM; Harrison DE. 2007. Heterozygous kit mutants with little or no apparent anemia exhibit large defects in overall hematopoietic stem cell function. Exp Hematol 35(2):214-220. [PubMed: 17258070] [MGI Ref ID J:123190]
Tan JC; Nocka K; Ray P; Traktman P; Besmer P. 1990. The dominant W42 spotting phenotype results from a missense mutation in the c-kit receptor kinase. Science 247(4939):209-12. [PubMed: 1688471] [MGI Ref ID J:10187]
Tsujimura T; Koshimizu U; Katoh H; Isozaki K; Kanakura Y; Tono T; Adachi S; Kasugai T; Tei H; Nishimune Y; Nomura S; Kitamura Y. 1993. Mast cell number in the skin of heterozygotes reflects the molecular nature of c-kit mutation. Blood 81(10):2530-8. [PubMed: 7683920] [MGI Ref ID J:27513]
Wilson MJ; Bowles J; Koopman P. 2006. The matricellular protein SPARC is internalized in Sertoli, Leydig, and germ cells during testis differentiation. Mol Reprod Dev 73(5):531-9. [PubMed: 16425238] [MGI Ref ID J:109014]
Wilson MJ; Liaw L; Koopman P. 2005. Osteopontin and related SIBLING glycoprotein genes are expressed by Sertoli cells during mouse testis development. Dev Dyn 233(4):1488-95. [PubMed: 15937924] [MGI Ref ID J:99574]
Ye L; Zhang EY; Xiong Q; Astle CM; Zhang P; Li Q; From AH; Harrison DE; Zhang JJ. 2012. Aging Kit mutant mice develop cardiomyopathy. PLoS One 7(3):e33407. [PubMed: 22428044] [MGI Ref ID J:187053]
Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.
Pricing and Purchasing
Pricing, Supply Level & Notes, Controls
| Pricing for USA, Canada and Mexico shipping destinations |
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Cryopreserved
Cryopreserved Mice - Ready for Recovery
Animals Provided
Price (US dollars $) Cryorecovery* $3175.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Standard Supply
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.
Supply Notes
Cryorecovery - Standard.
Progeny testing is not required.
The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 11 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.Cryorecovery to establish a Dedicated Supply for greater quantities of mice
Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).
| Pricing for International shipping destinations |
|
Cryopreserved
Cryopreserved Mice - Ready for Recovery
Animals Provided
Price (US dollars $) Cryorecovery* $4127.50 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Standard Supply
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.
Supply Notes
Cryorecovery - Standard.
Progeny testing is not required.
The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 11 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.Cryorecovery to establish a Dedicated Supply for greater quantities of mice
Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).
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Standard Supply
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.
General Supply Notes
- Genomic DNA is available for this strain from the Mouse DNA Resource.
Control Information
| Control | ||
|---|---|---|
| Wild-type from the colony | ||
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
| Control Pricing Information for Genetically Engineered Mutant Strains. | ||
Payment Terms and Conditions
Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.
See Terms of Use tab for General Terms and Conditions
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering Information
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Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
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| phone: | 207-288-6470 |
| fax: | 207-288-6655 |
JAX® Mice, Products & Services Conditions of Use
"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.No Warranty
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