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- Description
- Phenotype
- Genes & alleles
- Genotyping
- Health & husbandry
- References
- Purchasing information
- Terms of Use
Description
The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.
Strain Information
Type Minor Histocompatibility Congenic; Mutant Strain; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Species laboratory mouse Background Strain C57BL/6By Donor Strain BALB/cBy Generation F38p
Generation DefinitionsDonating Investigator Don Bailey, The Jackson Laboratory Development
Dr. Don Bailey, then at The Jackson Laboratory, generated a panel of congenic resistant lines distinct at histocompatibility loci, with selection for minor histocompatibility loci, by crossing BALB/CBy females with C57BL/6By males and then backcrossing at each generation to a C57BL/6J male. At backcross generation 5 orthotopic tailskin graft tests were done to identify lines bearing BALB/cBy-derived congenic intervals with minor histocompatibility loci. This backcrossing, with testing, was continued until siblings at backcross generation 11 or more were intercrossed to breed the congenic interval to homozygosity and each strain was maintained by sibling inbreeding (Bailey, 1975).
Control Information
| Control | ||
|---|---|---|
| 001139 C57BL/6ByJ | ||
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying Ahrb-2 allele
000645 A/HeJ 000646 A/J 000370 B6.C-H38c/(HW119)ByJ 001026 BALB/cByJ 000653 BUB/BnJ 000659 C3H/HeJ 000656 CBA/J 000657 CE/J 000352 CXB2/ByJ 000353 CXB3/ByJ 000354 CXB4/ByJ 000355 CXB5/ByJ 000357 CXB7/ByJ 000673 HRS/J 000679 P/J 000930 PERA/EiJ 000644 SEA/GnJ 000280 SF/CamEiJ View Strains carrying Ahrb-2 (18 strains)
000690 129P3/J 000645 A/HeJ 000646 A/J 000648 AKR/J 002920 B6(D2N).Spretus-Ahrb-3/J 006203 B6.129(FVB)-Ahrtm3.1Bra/J 002831 B6.129-Ahrtm1Bra/J 000136 B6.C-H34c/(HW22)ByJ 000370 B6.C-H38c/(HW119)ByJ 008599 B6.Cg-Cyp1a2/Cyp1a1tm2Dwn Ahrd Tg(CYP1A1,CYP1A2)1Dwn/DwnJ 002921 B6.D2N-Ahrd/J 002727 B6;129-Ahrtm1Bra/J 001026 BALB/cByJ 000652 BDP/J 000653 BUB/BnJ 000659 C3H/HeJ 000663 C57BL/6By 001139 C57BL/6ByJ 000664 C57BL/6J 000662 C57BLKS/J 000667 C57BR/cdJ 000668 C57L/J 000669 C58/J 000926 CAROLI/EiJ 000928 CAST/EiJ 000656 CBA/J 000657 CE/J 000351 CXB1/ByJ 000352 CXB2/ByJ 000353 CXB3/ByJ 000354 CXB4/ByJ 000355 CXB5/ByJ 000356 CXB6/ByJ 000357 CXB7/ByJ 002937 D2.B6-Ahrb-1/J 000671 DBA/2J 000673 HRS/J 000674 I/LnJ 000675 LG/J 000676 LP/J 000677 MA/MyJ 000550 MOLF/EiJ 000684 NZB/BlNJ 000679 P/J 000930 PERA/EiJ 000726 RBF/DnJ 000682 RF/J 000644 SEA/GnJ 000280 SF/CamEiJ 000686 SJL/J 001146 SPRET/EiJ 000688 ST/bJ 000689 SWR/J 000693 WC/ReJ KitlSl/J 000933 YBR/EiJ
Phenotype
Phenotype Information
This mouse can be used to support research in many areas including:
Immunology and Inflammation Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers
Genes & Alleles
Gene & Allele Information provided by MGI
| Gene Symbol and Name | H17, histocompatibility 17 | ||
|---|---|---|---|
| Chromosome | 12 | ||
| Gene Common Name(s) | H-17; | ||
| Allele Symbol | Ahrb-2 | ||
| Allele Name | b-2 variant | ||
| Allele Type | Not Applicable | ||
| Common Name(s) | Ahb-2; Ahh; | ||
| Strain of Origin | BALB/cBy | ||
| Gene Symbol and Name | Ahr, aryl-hydrocarbon receptor | ||
| Chromosome | 12 | ||
| Gene Common Name(s) | Ah; Ahh; Ahre; In; aromatic hydrocarbon responsiveness; aryl hydrocarbon hydroxylase; bHLHe76; dioxin receptor; inflammatory reactivity; | ||
References
References provided by MGI
Selected Reference(s)
Bailey DW. 1975. Genetics of histocompatibility in mice. I. New loci and congenic lines. Immunogenetics 2:249-256. [MGI Ref ID J:4420]
Additional References
Poland A; Glover E; Taylor BA. 1987. The murine Ah locus: a new allele and mapping to chromosome 12. Mol Pharmacol 32(4):471-8. [PubMed: 2823093] [MGI Ref ID J:8895]
Ahrb-2 relatedNebert DW; Considine N; Owens IS. 1973. Genetic expression of aryl hydrocarbon hydroxylase induction. VI. Control of other aromatic hydrocarbon-inducible mono-oxygenase activities at or near the same genetic locus. Arch Biochem Biophys 157(1):148-59. [PubMed: 4716952] [MGI Ref ID J:84313]
Nebert DW; Gielen JE. 1972. Genetic regulation of aryl hydrocarbon hydroxylase induction in the mouse. Fed Proc 31(4):1315-25. [PubMed: 4114109] [MGI Ref ID J:5282]
Nebert DW; Jensen NM; Shinozuka H; Kunz HW; Gill TJ 3rd. 1982. The Ah phenotype. Survey of forty-eight rat strains and twenty inbred mouse strains. Genetics 100(1):79-87. [PubMed: 7095422] [MGI Ref ID J:6809]
Nebert DW; Robinson JR; Niwa A; Kumaki K; Poland AP. 1975. Genetic expression of aryl hydrocarbon hydroxylase activity in the mouse. J Cell Physiol 85(2 Pt 2 Suppl 1):393-414. [PubMed: 1091656] [MGI Ref ID J:84317]
Niwa A; Kumaki K; Nebert DW; Poland AP. 1975. Genetic expression of aryl hydrocarbon hydroxylase activity in the mouse. Distinction between the 'responsive' homozygote and heterozygote at the Ah locus. Arch Biochem Biophys 166(2):559-64. [PubMed: 1119809] [MGI Ref ID J:84316]
Poland A; Glover E. 1990. Characterization and strain distribution pattern of the murine Ah receptor specified by the Ahd and Ahb-3 alleles. Mol Pharmacol 38(3):306-12. [PubMed: 2169579] [MGI Ref ID J:34840]
Poland A; Glover E; Taylor BA. 1987. The murine Ah locus: a new allele and mapping to chromosome 12. Mol Pharmacol 32(4):471-8. [PubMed: 2823093] [MGI Ref ID J:8895]
Poland A; Palen D; Glover E. 1994. Analysis of the four alleles of the murine aryl hydrocarbon receptor. Mol Pharmacol 46(5):915-21. [PubMed: 7969080] [MGI Ref ID J:22144]
Robinson JR; Considine N; Nebert DW. 1974. Genetic expression of aryl hydrocarbon hydroxylase induction. Evidence for the involvement of other genetic loci. J Biol Chem 249(18):5851-9. [PubMed: 4413562] [MGI Ref ID J:84315]
Schmid FA; Pena RC; Robinson W; Tarnowski GS. 1967. Toxicity of intraperitoneal injections of 7, 12-dimethylbenz[a]anthracene in inbred mice. Cancer Res 27(3):558-62. [PubMed: 6021513] [MGI Ref ID J:26440]
Schmidt JV; Carver LA; Bradfield CA. 1993. Molecular characterization of the murine Ahr gene. Organization, promoter analysis, and chromosomal assignment. J Biol Chem 268(29):22203-9. [PubMed: 8408082] [MGI Ref ID J:15153]
Smith AG; Clothier B; Robinson S; Scullion MJ; Carthew P; Edwards R; Luo J; Lim CK; Toledano M. 1998. Interaction between iron metabolism and 2,3,7,8-tetrachlorodibenzo-p-dioxin in mice with variants of the Ahr gene: a hepatic oxidative mechanism. Mol Pharmacol 53(1):52-61. [PubMed: 9443932] [MGI Ref ID J:45850]
Thomas PE; Hutton JJ; Taylor BA. 1973. Genetic relationship between aryl hydrocarbon hydroxylase inducibility and chemical carcinogen induced skin ulceration in mice. Genetics 74(4):655-9. [PubMed: 4750810] [MGI Ref ID J:5387]
Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, RG10/RG30.
Purchasing information
Pricing, Supply Level & Notes, Controls
| Pricing for USA, Canada and Mexico shipping destinations |
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Cryopreserved
Cryopreserved Mice - Ready for Recovery
Animals Provided
Price (US dollars $) Cryorecovery* $1980.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Standard Supply
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information.
Supply Notes
- Cryorecovery - Standard.
We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. The total number of animals provided, their gender and genotype will vary. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 13 and 16 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).
| Pricing for International shipping destinations |
|
|
Cryopreserved
Cryopreserved Mice - Ready for Recovery
Animals Provided
Price (US dollars $) Cryorecovery* $2574.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Standard Supply
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information.
Supply Notes
- Cryorecovery - Standard.
We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. The total number of animals provided, their gender and genotype will vary. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 13 and 16 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).
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Standard Supply
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information.
General Supply Notes
- Genomic DNA is available for this strain from the Mouse DNA Resource.
Control Information
| Control | ||
|---|---|---|
| 001139 C57BL/6ByJ | ||
| Considerations for Choosing Controls | ||
| Control Pricing Information for Genetically Engineered Mutant Strains. | ||
Payment Terms and Conditions
Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.
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The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering Information
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| phone: | 207-288-6470 |
| fax: | 207-288-6655 |
JAX® Mice, Products & Services Conditions of Use
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