Strain Name:

C57BL/6J-KitW-37J/J

Stock Number:

000134

Availability:

Repository-Cryopreserved

Description

Strain Information

Type Coisogenic; Mutant Strain; Spontaneous Mutation;
Additional information on Genetically Engineered Mutant Mice.
Specieslaboratory mouse
GenerationN33

Related Strains

View Strains carrying other alleles of Kit     (36 strains)

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms
      assigned by genotype

KitW-37J/Kit+

        involves: C57BL/6J
  • skin/coat/nails phenotype
  • irregular coat pigmentation (MGI Ref ID J:6571)
    • some mice exhibit mosaic coat patterns
  • white spotting (MGI Ref ID J:6571)
    • 85% of the coat is white with flecks of pigmented hair on the head, around the eyes, at the base of the ears and on the rump
  • hematopoietic system phenotype
  • polycythemia (MGI Ref ID J:6571)
    • borderline
  • pigmentation phenotype
  • irregular coat pigmentation (MGI Ref ID J:6571)
    • some mice exhibit mosaic coat patterns
  • white spotting (MGI Ref ID J:6571)
    • 85% of the coat is white with flecks of pigmented hair on the head, around the eyes, at the base of the ears and on the rump

KitW-37J/Kit+

        involves: C57BL/6 * C57BL/6J
  • skin/coat/nails phenotype
  • diluted coat color (MGI Ref ID J:27513)
    • slightly
  • white spotting (MGI Ref ID J:27513)
  • immune system phenotype
  • decreased mast cell number (MGI Ref ID J:27513)
    • mice exhibit slightly fewer mast cells in the skin than wild-type mice
  • hematopoietic system phenotype
  • decreased mast cell number (MGI Ref ID J:27513)
    • mice exhibit slightly fewer mast cells in the skin than wild-type mice
  • pigmentation phenotype
  • diluted coat color (MGI Ref ID J:27513)
    • slightly
  • white spotting (MGI Ref ID J:27513)

KitW-37J/KitW-37J

        involves: C57BL/6J
  • lethality-prenatal/perinatal
  • perinatal lethality (MGI Ref ID J:6571)
    • mice die in mid-gestation or immediately after birth
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

KitW-37J related

Cancer Research
Growth Factors/Receptors/Cytokines
Increased Tumor Incidence (Gonadal Tumors: ovarian)
Oncogenes

Dermatology Research
Color and White Spotting Defects

Developmental Biology Research
Neural Crest Defects

Endocrine Deficiency Research
Bone/Bone Marrow Defects
Gonad Defects
Skin Defects

Immunology and Inflammation Research
Immunodeficiency (Mast Cell Deficiency)

Mouse/Human Gene Homologs
piebaldism

Neurobiology Research
Receptor Defects
Vestibular and Hearing Defects

Reproductive Biology Research
Developmental Defects Affecting Gonads (germ cell deficient)
Fertility Defects
Gonadal Tumors (ovarian)

Research Tools
Immunology and Inflammation Research (Mast Cell Deficiency)

Sensorineural Research
Vestibular and Hearing Defects

Genes & Alleles

Gene & Allele Information

Allele Symbol KitW-37J
Allele Name dominant spotting 37 Jackson
Allele Type Spontaneous
Common Name(s) W37;
Strain of OriginC57BL/6J
Gene Symbol and Name Kit, kit oncogene
Chromosome 5
Gene Common Name(s) Bs; C-Kit; CD117; Dominant white spotting; Fdc; Gsfsco1; Gsfsco5; Gsfsow3; PBT; SCFR; SCO1; SCO5; SOW3; Ssm; Steel Factor Receptor; Tr-kit; W; belly-spot; dominant spotting; gsf spotted coat 1; gsf spotted coat 5; phenotype like Sl or W 3; spotted sterile male;
Molecular Note Analysis of the coding sequence showed a G to A point mutation at nucleotide 1772 that results in a glutamic acid to lysine substitution at amino acid 582, four amino acids from the N-terminus of the kinase domain. [MGI Ref ID J:10528]

Genotyping

Genotyping Information

This strain will not have a genotyping protocol or one is not currently available.

Helpful Links

Optimizing PCR Protocols

References

References

Additional References

Arguello F; Furlanetto RW; Baggs RB; Graves BT; Harwell SE; Cohen HJ; Frantz CN. 1992. Incidence and distribution of experimental metastases in mutant mice with defective organ microenvironments (genotypes Sl/Sld and W/Wv). Cancer Res 52(8):2304-9. [PubMed: 1559233]  [MGI Ref ID J:468]

Kitamura Y; Kasugai T; Ebi Y; Nomura S. 1991. Fibroblast-dependent differentiation/proliferation of mast cells. Skin Pharmacol 4 Suppl 1:2-7. [PubMed: 1764248]  [MGI Ref ID J:619]

Murphy ED. 1972. Hyperplastic and early neoplastic changes in the ovaries of mice after genic deletion of germ cells. J Natl Cancer Inst 48(5):1283-95. [PubMed: 4337905]  [MGI Ref ID J:5274]

Nocka K; Tan JC; Chiu E; Chu TY; Ray P; Traktman P; Besmer P. 1990. Molecular bases of dominant negative and loss of function mutations at the murine c-kit/white spotting locus: W37, Wv, W41 and W. EMBO J 9(6):1805-13. [PubMed: 1693331]  [MGI Ref ID J:10528]

KitW-37J related

Geissler EN; McFarland EC; Russell ES. 1981. Analysis of pleiotropism at the dominant white-spotting (W) locus of the house mouse: a description of ten new W alleles. Genetics 97(2):337-61. [PubMed: 7274658]  [MGI Ref ID J:6571]

Lourenssen S; Motro B; Bernstein A; Diamond J. 2000. Defects in sensory nerve numbers and growth in mutant Kit and Steel mice. Neuroreport 11(6):1159-65. [PubMed: 10817584]  [MGI Ref ID J:103680]

Nocka K; Tan JC; Chiu E; Chu TY; Ray P; Traktman P; Besmer P. 1990. Molecular bases of dominant negative and loss of function mutations at the murine c-kit/white spotting locus: W37, Wv, W41 and W. EMBO J 9(6):1805-13. [PubMed: 1693331]  [MGI Ref ID J:10528]

Silvers WK. 1979. The Coat Colors of Mice; A Model for Mammalian Gene Action and Interaction. In: The Coat Colors of Mice. Springer-Verlag, New York.  [MGI Ref ID J:78801]

Tsujimura T; Koshimizu U; Katoh H; Isozaki K; Kanakura Y; Tono T; Adachi S; Kasugai T; Tei H; Nishimune Y; Nomura S; Kitamura Y. 1993. Mast cell number in the skin of heterozygotes reflects the molecular nature of c-kit mutation. Blood 81(10):2530-8. [PubMed: 7683920]  [MGI Ref ID J:27513]

Health & husbandry

Health & Colony Maintenance Information

Currently there no information available for this strain. This may be due to the supply level of this strain.

Purchasing information

Pricing, Supply Level & Notes, Controls, General Terms & Conditions

Pricing

Pricing for USA, Canada and Mexico shipping destinations View International pricing
Weeks of AgePrice*Gender
Cryorecovery Fee $1900.00
*Price(s) in US dollars ($)

Additional Supply Details

Pricing for International shipping destinations View USA Canada and Mexico pricing
Weeks of AgePrice*Gender
Cryorecovery Fee $2470.00
*Price(s) in US dollars ($)

Additional Supply Details

Supply Details

Standard SupplyRepository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information.
Supply Notes
  • Cryorecovery - Standard.
    The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two males and two females (two pairs) will be provided, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the delivery time to approximately 25 weeks. At least one member of each pair will be of known genotype and will carry the mutation if it is a mutant strain. Please note that pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Price represents a repository maintenance fee, which includes the cost of recovery of the strain from the cryopreservation resource and the periodic replacement of the frozen embryos used for recovery.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
    One to two pairs will be recovered to establish a Dedicated Supply of mice. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 or 1-207-288-5845.

  • Genomic DNA is available for this strain from the Mouse DNA Resource.

General Terms and Conditions


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General Terms and Conditions


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