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- Description
- Phenotype
- Genes & alleles
- Genotyping
- Health & husbandry
- References
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Description
Strain Information
Former Names A.BY-H2b H2-T18b/SnJ (Changed: 15-DEC-04 ) Type Congenic; Major Histocompatibility Congenic; Mutant Strain; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Mating System Homozygote x Homozygote (Female x Male) 01-MAR-06 Species laboratory mouse Background Strain A/WySn Donor Strain Non-inbred stock carrying T (brachyury) H2 Haplotype bc (see, Fischer Lindahl K 1997 and Shen FW 1982) Generation n11f101 (31-DEC-08) Appearance
albino
Related Genotype: a/a Tyrp1b/Tyrp1b Tyrc/TyrcDescription
Dr. George Snell, of The Jackson Laboratory, created this H2-congenic strain by crossing of mice of a non-inbred stock carrying the brachyury mutation (and therefore called BY) to mice of the A/Lilly inbred strain, then repeatedly backcrossing to the latter strain mice that proved resistant to A-derived tumors. A/Lilly was a subline of strain A that Snell obtained from the Lilly Company after the 1947 fire at The Jackson Laboratory; when it was learned that this strain was contaminated, Snell performed a single additional backcross to the A/WySn subline, taking it to generation N11 (Rodgers 2004; Klein 1989). The BY stock apparently was obtained from Dr. Dobrovolskaia-Zavadskaia, who described a short-tailed mouse sired by a gonadally-irradiated male; she believed the brachyury mutation not to have been caused by the radiation, but to have been a pre-existing spontaneous mutation (Dobrovoskaya-Zajadkaya 1927; Rodgers 2004). In a subsequent article, she described short tailed (brachyure) and tailless (anoure) mice - the latter presumaby T/t - from the same litters, but these may have come from a different investigator (Rodgers 2004).The H2-T18 locus, which previously was called Tla and whose encoded proteins have been referred to as TL antigens, was discovered by Dr. Lloyd Old and colleagues when antisera produced by C57BL/6 mice following immunization with leukemia cells from A strain mice were found to react with thymocytes from a subset of mouse strains, as well as with cells of particular leukemias. Interestingly, some leukemias expressed the reacive antigen despite being from mice of strains whose thymocytes were negative for the antigen. Different antigens and combinations of antigens were identified in thymocytes of various mouse strains using a series of antisera. By such serological analysis, thymocytes from mice of all H2b strains were negative for any TL antigen. (For a review of the Tla genes and their encoded antigens and additional references, see Chorney et al. 1982.)
This strain, like C57L, LP/J and 129 substrains, was classified in early articles dealing with H2-T18/Tla/TL as having the null, H2-T18b haplotype of other H2b strains. Shen et al. (1982), using a panel of monoclonal antibodies, identified a new Tla specificity, which they assigned the f haplotype, shared by this subset of otherwise H2b strains. Snell realized earlier from results of transplantation studies that A.BY differed from other H2b strains and that the difference mapped to the region of Tla; he therefore proposed to call the H2 haplotype of A.BY bc, as this was the next H2b variant in the series. We therefore have renamed this strain accordingly.
Control Information
| Control | ||
|---|---|---|
| 000647 A/WySnJ | ||
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying other alleles of H2-T18
View Strains carrying other alleles of H2-T18 (33 strains)
Additional Web Information
Genetic Quality Control Annual Report
Phenotype
Phenotype Information
This mouse can be used to support research in many areas including:
Immunology and Inflammation Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers
Genes & Alleles
Gene & Allele Information
| Gene Symbol and Name | H2-T18, histocompatibility 2, T region locus 18 | ||
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| Chromosome | 17 | ||
| Gene Common Name(s) | H-2T18; TL Ag; Tla; thymus leukemia antigen; | ||
| Gene Symbol and Name | H2, histocompatibility-2, MHC | ||
| Chromosome | 17 | ||
| Gene Common Name(s) | H-2; MHC-II; | ||
Genotyping
Genotyping Information
This strain will not have a genotyping protocol or one is not currently available.
Helpful Links
Genotyping resources and troubleshooting
References
References
Selected Reference(s)
Fischer Lindahl K. 1997. On naming H2 haplotypes: functional significance of MHC class Ib alleles. Immunogenetics 46(1):53-62. [PubMed: 9148789] [MGI Ref ID J:41130]
Additional References
Shen FW; Chorney MJ; Boyse EA. 1982. Further polymorphism of the Tla locus defined by monoclonal TL antibodies. Immunogenetics 15(6):573-8. [PubMed: 7106865] [MGI Ref ID J:6828]
Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Room Number AX12
Colony Maintenance
Mating System Homozygote x Homozygote (Female x Male) 01-MAR-06 Diet Information LabDiet® 5K52/5K67
Purchasing information
Pricing, Supply Level & Notes, Controls, General Terms & Conditions
Pricing
| Pricing for USA, Canada and Mexico shipping destinations |
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Weeks of Age Price (US dollars $) Gender Genotypes Provided Individual Mouse $55.60 Female or Male Homozygous for H2bc, Homozygous for H2-T18f
Additional Supply Details
| Pricing for International shipping destinations |
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Weeks of Age Price (US dollars $) Gender Genotypes Provided Individual Mouse $72.30 Female or Male Homozygous for H2bc, Homozygous for H2-T18f
Additional Supply Details
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Supply Details
| Standard Supply | Repository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of approximately nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within two business days following order placement. |
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| Supply Notes |
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Control Information
| Control | ||
|---|---|---|
| 000647 A/WySnJ | ||
| Considerations for Choosing Controls | ||
| USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
| International - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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