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Description
Strain Information
Former Names C57BL/6J-Lx KitW-v/J (Changed: 15-DEC-04 ) Type Congenic; Mutant Strain; Additional information on Genetically Engineered Mutant Mice. Species laboratory mouse Generation N109p Description
Kit mice possess pleiotropic defects in pigment-forming cells, germ cells, RBC's and mast cells. In addition, they exhibit impaired resistance to parasitic infection and an intrinsic progenitor cell defect. KitW-v homozygotes resemble KitW homozygotes in color, anemia, and germ cells, but many of them survive to maturity. The lack of germ cells in mutant mice leads to the development of some ovarian tumors (mesotheliomas and granulosa cell), associated with an overproduction of pituitary gonadotropic hormone. Heterozygous lx mice show preaxial polydactyly (including hyperphalangy of the first digit) of the hindfeet. Homozygotes show preaxial polydactyly or oligodactyly of the hindfeet, reduction of the tibia, loss of part of the femur and pubis, decrease in number of presacral vertebrae, and anomalies of the urogenital system including horseshoe kidney, hydronephrosis, and hydroureter.Although homozygous KitW-v/KitW-v have been described as being viable, Dr. Jane Barker of The Jackson Laboratory has found that in her colony C57BL/6J-KitW-v homozygotes die at birth or soon thereafter.
Control Information
| Control | ||
|---|---|---|
| Untyped from the colony | ||
| Wild-type from the colony | ||
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying KitW-v allele
000599 B6 x B6CBCa Aw-J/A-T(5;13)264Ca KitW-v/J 000350 B6By.Cg-KitW-v MitfMi-wh T/J 000049 C57BL/6J-KitW-v/J 100410 WBB6F1/J-KitW/KitW-v/J View Strains carrying KitW-v (4 strains)
006564 B6(C)-KitW-41J Gusbmps/BrkJ 000495 B6.C-H38c/By-KitW-56J/J 000560 B6.C-H7b/By KitW-50J/J 000122 B6.C3-KitW-44J/J 000991 B6.C58-KitW-57J/J 002283 B6.Cg-KitW-19H/EiJ 000133 B6.Cg-KitW-24J/J 000139 B6.Cg-KitW-25J/J 005051 B6.Cg-KitW-sh/HNihrJaeBsmJ 000164 B6.Cg-KitW/J 000171 B6.D2-KitW-45J/J 001563 B6.D2-KitW-73J/J 001177 B6.LP-KitW-49J/J 000627 C3H/HeJ-KitW-x/J 000847 C3Sn.B6-KitW-39J/J 000166 C57BL/6J-KitW-17J/J 000167 C57BL/6J-KitW-18J/J 000169 C57BL/6J-KitW-20J/J 000117 C57BL/6J-KitW-34J/J 000128 C57BL/6J-KitW-35J/J 000134 C57BL/6J-KitW-37J/J 000062 C57BL/6J-KitW-39J/J 000121 C57BL/6J-KitW-40J/J 000119 C57BL/6J-KitW-41J/J 000127 C57BL/6J-KitW-42J/J 000129 C57BL/6J-KitW-43J/J 000990 C57BL/6J-KitW-55J/J 001179 C57BL/6J-KitW-62J/J 000965 CBACa.C3-KitW-x/J 000092 FL/1Re-KitW/J 000993 NZB/BlNJ-KitW-59J/J 000692 WB/ReJ KitW/J 100410 WBB6F1/J-KitW/KitW-v/J
Additional Web Information
Congenic Nomenclature
Phenotype
Phenotype Information
This mouse can be used to support research in many areas including:KitW-v related
Lx relatedCancer Research
Growth Factors/Receptors/Cytokines
Increased Tumor Incidence (Gonadal Tumors: ovarian)
Oncogenes
Dermatology Research
Color and White Spotting Defects
Developmental Biology Research
Neural Crest Defects
Endocrine Deficiency Research
Bone/Bone Marrow Defects
Gonad Defects
Skin Defects
Immunology and Inflammation Research
Immunodeficiency (Mast Cell Deficiency)
Mouse/Human Gene Homologs
piebaldism
synpolydactyly
Neurobiology Research
Receptor Defects
Vestibular and Hearing Defects
Reproductive Biology Research
Developmental Defects Affecting Gonads (germ cell deficient)
Fertility Defects
Gonadal Tumors (ovarian)
Research Tools
Immunology and Inflammation Research (Mast Cell Deficiency)
Sensorineural Research
Vestibular and Hearing Defects
Developmental Biology Research
Internal/Organ Defects (urogenital)
Skeletal Defects
Internal/Organ Research
Kidney Defects
Genes & Alleles
Gene & Allele Information
| Allele Symbol | KitW-v | ||
|---|---|---|---|
| Allele Name | viable dominant spotting | ||
| Allele Type | Spontaneous | ||
| Common Name(s) | KitWv; Wv; Wv; | ||
| Strain of Origin | C57BL | ||
| Gene Symbol and Name | Kit, kit oncogene | ||
| Chromosome | 5 | ||
| Gene Common Name(s) | Bs; C-Kit; CD117; Dominant white spotting; Fdc; Gsfsco1; Gsfsco5; Gsfsow3; PBT; SCFR; SCO1; SCO5; SOW3; Ssm; Steel Factor Receptor; Tr-kit; W; belly-spot; dominant spotting; gsf spotted coat 1; gsf spotted coat 5; phenotype like Sl or W 3; spotted sterile male; | ||
| Molecular Note | A C to T point mutation at nucleotide 2007 results in a threonine to methionine substitution at amino acid 660. [MGI Ref ID J:24351] | ||
| Allele Symbol | Lx | ||
| Allele Name | luxate | ||
| Allele Type | Spontaneous | ||
| Strain of Origin | fancier's silver mouse | ||
| Molecular Note | The luxate mutation was found in descendants of a silver mouse obtained from a fancier. | ||
Genotyping
Genotyping Information
This strain will not have a genotyping protocol or one is not currently available.
Helpful Links
Optimizing PCR Protocols
References
References
Additional References
Arguello F; Furlanetto RW; Baggs RB; Graves BT; Harwell SE; Cohen HJ; Frantz CN. 1992. Incidence and distribution of experimental metastases in mutant mice with defective organ microenvironments (genotypes Sl/Sld and W/Wv). Cancer Res 52(8):2304-9. [PubMed: 1559233] [MGI Ref ID J:468]
Kitamura Y; Kasugai T; Ebi Y; Nomura S. 1991. Fibroblast-dependent differentiation/proliferation of mast cells. Skin Pharmacol 4 Suppl 1:2-7. [PubMed: 1764248] [MGI Ref ID J:619]
Murphy ED. 1972. Hyperplastic and early neoplastic changes in the ovaries of mice after genic deletion of germ cells. J Natl Cancer Inst 48(5):1283-95. [PubMed: 4337905] [MGI Ref ID J:5274]
Nocka K; Tan JC; Chiu E; Chu TY; Ray P; Traktman P; Besmer P. 1990. Molecular bases of dominant negative and loss of function mutations at the murine c-kit/white spotting locus: W37, Wv, W41 and W. EMBO J 9(6):1805-13. [PubMed: 1693331] [MGI Ref ID J:10528]
Yada Y; Makino S; Chigusa-Ishiwa S; Shiroishi T. 2002. The mouse polydactylous mutation, luxate (lx), causes anterior shift of the anteroposterior border in the developing hindlimb bud. Int J Dev Biol 46(7):975-82. [PubMed: 12455637] [MGI Ref ID J:81331]
KitW-v relatedLx relatedAllix S; Reyes-Gomez E; Aubin-Houzelstein G; Noel D; Tiret L; Panthier JJ; Bernex F. 2008. Uterine contractions depend on KIT-positive interstitial cells in the mouse: genetic and pharmacological evidence. Biol Reprod 79(3):510-7. [PubMed: 18480468] [MGI Ref ID J:140900]
Anderson AL; Sporici R; Lambris J; Larosa D; Levinson AI. 2006. Pathogenesis of B-cell superantigen-induced immune complex-mediated inflammation. Infect Immun 74(2):1196-203. [PubMed: 16428769] [MGI Ref ID J:104987]
Antonchuk J; Hyland CD; Hilton DJ; Alexander WS. 2004. Synergistic effects on erythropoiesis, thrombopoiesis, and stem cell competitiveness in mice deficient in thrombopoietin and steel factor receptors. Blood 104(5):1306-13. [PubMed: 15138166] [MGI Ref ID J:92703]
April CS; Barsh GS. 2007. Distinct Pigmentary and Melanocortin 1 Receptor-Dependent Components of Cutaneous Defense against Ultraviolet Radiation. PLoS Genet 3(1):e9. [PubMed: 17222061] [MGI Ref ID J:118235]
Arinobu Y; Iwasaki H; Gurish MF; Mizuno S; Shigematsu H; Ozawa H; Tenen DG; Austen KF; Akashi K. 2005. Developmental checkpoints of the basophil/mast cell lineages in adult murine hematopoiesis. Proc Natl Acad Sci U S A 102(50):18105-10. [PubMed: 16330751] [MGI Ref ID J:104357]
Ayach BB; Yoshimitsu M; Dawood F; Sun M; Arab S; Chen M; Higuchi K; Siatskas C; Lee P; Lim H; Zhang J; Cukerman E; Stanford WL; Medin JA; Liu PP. 2006. Stem cell factor receptor induces progenitor and natural killer cell-mediated cardiac survival and repair after myocardial infarction. Proc Natl Acad Sci U S A 103(7):2304-9. [PubMed: 16467148] [MGI Ref ID J:106065]
Azuma T; Dojyo M; Ito S; Yamazaki Y; Miyaji H; Ito Y; Suto H; Kuriyama M; Kato T; Kohli Y. 1999. Bile reflux due to disturbed gastric movement is a cause of spontaneous gastric ulcer in W/Wv mice. Dig Dis Sci 44(6):1177-83. [PubMed: 10389693] [MGI Ref ID J:57206]
Balvers M; Spiess AN; Domagalski R; Hunt N; Kilic E; Mukhopadhyay AK; Hanks E; Charlton HM; Ivell R. 1998. Relaxin-like factor expression as a marker of differentiation in the mouse testis and ovary. Endocrinology 139(6):2960-70. [PubMed: 9607807] [MGI Ref ID J:114270]
Baumann U; Chouchakova N; Gewecke B; Kohl J; Carroll MC; Schmidt RE; Gessner JE. 2001. Distinct tissue site-specific requirements of mast cells and complement components C3/C5a receptor in IgG immune complex-induced injury of skin and lung. J Immunol 167(2):1022-7. [PubMed: 11441111] [MGI Ref ID J:120524]
Beamer WG; Tennent BJ. 1986. Gonadotropin uptake in genetic and irradiation models of ovarian tumorigenesis. Biol Reprod 34(4):761-70. [PubMed: 3085740] [MGI Ref ID J:48594]
Beckett EA; McGeough CA; Sanders KM; Ward SM. 2003. Pacing of interstitial cells of Cajal in the murine gastric antrum: neurally mediated and direct stimulation. J Physiol 553(Pt 2):545-59. [PubMed: 14500772] [MGI Ref ID J:105541]
Beckett EA; Ro S; Bayguinov Y; Sanders KM; Ward SM. 2007. Kit signaling is essential for development and maintenance of interstitial cells of Cajal and electrical rhythmicity in the embryonic gastrointestinal tract. Dev Dyn 236(1):60-72. [PubMed: 16937373] [MGI Ref ID J:116633]
Bernstein SE. 1969. Hereditary disorders of the rodent erythron. In: Genetics in Laboratory Animal Medicine. Natl Acad Sci Publ, Washington, DC. [MGI Ref ID J:30699]
Biedermann T; Kneilling M; Mailhammer R; Maier K; Sander CA; Kollias G; Kunkel SL; Hultner L; Rocken M. 2000. Mast cells control neutrophil recruitment during T cell-mediated delayed-type hypersensitivity reactions through tumor necrosis factor and macrophage inflammatory protein 2 J Exp Med 192(10):1441-52. [PubMed: 11085746] [MGI Ref ID J:65843]
Binstadt BA; Patel PR; Alencar H; Nigrovic PA; Lee DM; Mahmood U; Weissleder R; Mathis D; Benoist C. 2006. Particularities of the vasculature can promote the organ specificity of autoimmune attack. Nat Immunol 7(3):284-92. [PubMed: 16444258] [MGI Ref ID J:112604]
Boddy G; Daniel EE. 2005. Role of l-Ca(2+) channels in intestinal pacing in wild-type and W/W(V) mice. Am J Physiol Gastrointest Liver Physiol 288(3):G439-46. [PubMed: 15486346] [MGI Ref ID J:97237]
Bradley J; Baltus A; Skaletsky H; Royce-Tolland M; Dewar K; Page DC. 2004. An X-to-autosome retrogene is required for spermatogenesis in mice. Nat Genet 36(8):872-6. [PubMed: 15258580] [MGI Ref ID J:91708]
Brito FC; Kos L. 2008. Timeline and distribution of melanocyte precursors in the mouse heart. Pigment Cell Melanoma Res 21(4):464-70. [PubMed: 18444965] [MGI Ref ID J:138178]
Cable J; Barkway C; Steel KP. 1992. Characteristics of stria vascularis melanocytes of viable dominant spotting (Wv/Wv) mouse mutants. Hear Res 64(1):6-20. [PubMed: 1490901] [MGI Ref ID J:4062]
Cable J; Jackson IJ; Steel KP. 1995. Mutations at the W locus affect survival of neural crest-derived melanocytes in the mouse. Mech Dev 50(2-3):139-50. [PubMed: 7619726] [MGI Ref ID J:24351]
Cara DC; Ebbert KV; McCafferty DM. 2004. Mast cell-independent mechanisms of immediate hypersensitivity: a role for platelets. J Immunol 172(8):4964-71. [PubMed: 15067077] [MGI Ref ID J:89115]
Cattanach BM; Raspberry C; Beechey CV. 1995. XY sex reversal associated with autosomal deletions Mouse Genome 93:426. [MGI Ref ID J:133266]
Chen R; Ning G; Zhao ML; Fleming MG; Diaz LA; Werb Z; Liu Z. 2001. Mast cells play a key role in neutrophil recruitment in experimental bullous pemphigoid. J Clin Invest 108(8):1151-8. [PubMed: 11602622] [MGI Ref ID J:72195]
Chen Z; Li Z; Sakurai E; Izadi Mobarakeh J; Ohtsu H; Watanabe T; Watanabe T; Iinuma K; Yanai K. 2003. Chemical kindling induced by pentylenetetrazol in histamine H(1) receptor gene knockout mice (H(1)KO), histidine decarboxylase-deficient mice (HDC(-/-)) and mast cell-deficient W/W(v) mice. Brain Res 968(1):162-6. [PubMed: 12644274] [MGI Ref ID J:82735]
Chi MM; Powley TL. 2003. c-Kit mutant mouse behavioral phenotype: altered meal patterns and CCK sensitivity but normal daily food intake and body weight. Am J Physiol Regul Integr Comp Physiol 285(5):R1170-83. [PubMed: 12816741] [MGI Ref ID J:109372]
Choi IH; Shin YM; Park JS; Lee MS; Han EH; Chai OH; Im SY; Ha TY; Lee HK. 1998. Immunoglobulin E-dependent active fatal anaphylaxis in mast cell-deficient mice. J Exp Med 188(9):1587-92. [PubMed: 9802970] [MGI Ref ID J:50773]
Cimini M; Fazel S; Zhuo S; Xaymardan M; Fujii H; Weisel RD; Li RK. 2007. c-kit dysfunction impairs myocardial healing after infarction. Circulation 116(11 Suppl):I77-82. [PubMed: 17846329] [MGI Ref ID J:139839]
Cohn L; Homer RJ; MacLeod H; Mohrs M; Brombacher F; Bottomly K. 1999. Th2-induced airway mucus production is dependent on IL-4Ralpha, but not on eosinophils. J Immunol 162(10):6178-83. [PubMed: 10229862] [MGI Ref ID J:119786]
Corr M; Crain B. 2002. The role of FcgammaR signaling in the K/B x N serum transfer model of arthritis. J Immunol 169(11):6604-9. [PubMed: 12444173] [MGI Ref ID J:124384]
Couldrey C; Bradley HL; Bunting KD. 2005. A STAT5 modifier locus on murine chromosome 7 modulates engraftment of hematopoietic stem cells during steady-state hematopoiesis. Blood 105(4):1476-83. [PubMed: 15498858] [MGI Ref ID J:96602]
Crosby JR; Cieslewicz G; Borchers M; Hines E; Carrigan P; Lee JJ; Lee NA. 2002. Early phase bronchoconstriction in the mouse requires allergen-specific IgG. J Immunol 168(8):4050-4. [PubMed: 11937563] [MGI Ref ID J:125656]
D'Andrea MR; Saban MR; Gerard NP; Wershil BK; Saban R. 2005. Lack of neurokinin-1 receptor expression affects tissue mast cell numbers but not their spatial relationship with nerves. Am J Physiol Regul Integr Comp Physiol 288(2):R491-500. [PubMed: 15458971] [MGI Ref ID J:95761]
Daigo Y; Takayama I; Ponder BA; Caldas C; Ward SM; Sanders KM; Fujino MA. 2004. Novel human, mouse and xenopus genes encoding a member of the RAS superfamily of low-molecular-weight GTP-binding proteins and its downregulation in W/WV mouse jejunum. J Gastroenterol Hepatol 19(2):211-7. [PubMed: 14731133] [MGI Ref ID J:102004]
Daigo Y; Takayama I; Ward SM; Sanders KM; Fujino MA. 2004. Isolation of novel mouse genes that were differentially expressed in W/W(V) mouse fundus. J Gastroenterol 39(3):238-41. [PubMed: 15065000] [MGI Ref ID J:102305]
Daigo Y; Takayama I; Ward SM; Sanders KM; Fujino MA. 2003. Novel human and mouse genes encoding a shank-interacting protein and its upregulation in gastric fundus of W/WV mouse. J Gastroenterol Hepatol 18(6):712-8. [PubMed: 12753155] [MGI Ref ID J:103585]
Dastych J; Taub D; Hardison MC; Metcalfe DD. 1998. Tyrosine kinase-deficient Wv c-kit induces mast cell adhesion and chemotaxis. Am J Physiol 275(5 Pt 1):C1291-9. [PubMed: 9814978] [MGI Ref ID J:50928]
Deol MS. 1970. The origin of the acoustic ganglion and effects of the gene dominant spotting (Wv) in the mouse. J Embryol Exp Morphol 23(3):773-84. [PubMed: 5473311] [MGI Ref ID J:5179]
Depinay N; Hacini F; Beghdadi W; Peronet R; Mecheri S. 2006. Mast cell-dependent down-regulation of antigen-specific immune responses by mosquito bites. J Immunol 176(7):4141-6. [PubMed: 16547250] [MGI Ref ID J:129876]
Dev A; Nayernia K; Meins M; Adham I; Lacone F; Engel W. 2007. Mice deficient for RNA-binding protein brunol1 show reduction of spermatogenesis but are fertile. Mol Reprod Dev 74(11):1456-64. [PubMed: 17393433] [MGI Ref ID J:128362]
Dickens EJ; Edwards FR; Hirst GD. 2001. Selective knockout of intramuscular interstitial cells reveals their role in the generation of slow waves in mouse stomach. J Physiol 531(Pt 3):827-33. [PubMed: 11251061] [MGI Ref ID J:106573]
Dixit D; Zarate N; Liu LW; Boreham DR; Huizinga JD. 2006. Interstitial cells of Cajal and adaptive relaxation in the mouse stomach. Am J Physiol Gastrointest Liver Physiol 291(6):G1129-36. [PubMed: 16891301] [MGI Ref ID J:116896]
Dombrowicz D; Flamand V; Miyajima I; Ravetch JV; Galli SJ; Kinet JP. 1997. Absence of Fc epsilonRI alpha chain results in upregulation of Fc gammaRIII-dependent mast cell degranulation and anaphylaxis. Evidence of competition between Fc epsilonRI and Fc gammaRIII for limiting amounts of FcR beta and gamma chains. J Clin Invest 99(5):915-25. [PubMed: 9062349] [MGI Ref ID J:78651]
Dunford PJ; O'Donnell N; Riley JP; Williams KN; Karlsson L; Thurmond RL. 2006. The histamine H4 receptor mediates allergic airway inflammation by regulating the activation of CD4+ T cells. J Immunol 176(11):7062-70. [PubMed: 16709868] [MGI Ref ID J:131785]
Edelson BT; Li Z; Pappan LK; Zutter MM. 2004. Mast cell-mediated inflammatory responses require the alpha 2 beta 1 integrin. Blood 103(6):2214-20. [PubMed: 14645004] [MGI Ref ID J:88567]
Endo Y; Tabata T; Kuroda H; Tadano T; Matsushima K; Watanabe M. 1998. Induction of histidine decarboxylase in skeletal muscle in mice by electrical stimulation, prolonged walking and interleukin-1. J Physiol 509(Pt 2):587-98. [PubMed: 9575306] [MGI Ref ID J:106491]
Everett ET; Pablos JL; Harley RA; LeRoy EC; Norris JS. 1995. The role of mast cells in the development of skin fibrosis in tight-skin mutant mice. Comp Biochem Physiol A Physiol 110(2):159-65. [PubMed: 7704626] [MGI Ref ID J:24076]
Fazel S; Cimini M; Chen L; Li S; Angoulvant D; Fedak P; Verma S; Weisel RD; Keating A; Li RK. 2006. Cardioprotective c-kit+ cells are from the bone marrow and regulate the myocardial balance of angiogenic cytokines. J Clin Invest 116(7):1865-77. [PubMed: 16823487] [MGI Ref ID J:111717]
Fekete E; Kent EL. 1955. Transplantable mouse tumors Transplant Bull 2:61-62. [MGI Ref ID J:47052]
Feng BS; He SH; Zheng PY; Wu L; Yang PC. 2007. Mast cells play a crucial role in Staphylococcus aureus peptidoglycan-induced diarrhea. Am J Pathol 171(2):537-47. [PubMed: 17600127] [MGI Ref ID J:123928]
Finkelman FD; Morris SC; Orekhova T; Mori M; Donaldson D; Reiner SL; Reilly NL; Schopf L; Urban JF Jr. 2000. Stat6 regulation of in vivo IL-4 responses. J Immunol 164(5):2303-10. [PubMed: 10679064] [MGI Ref ID J:112038]
Forrest AS; Ordog T; Sanders KM. 2006. Neural regulation of slow-wave frequency in the murine gastric antrum. Am J Physiol Gastrointest Liver Physiol 290(3):G486-95. [PubMed: 16166340] [MGI Ref ID J:106050]
Fujimura T; Furukawa H; Doi Y; Makishima K; Fujimoto S. 1999. Immunoreactivity of endothelins and endothelin receptor in the stria vascularis of the mouse cochlea. Hear Res 128(1-2):135-46. [PubMed: 10082294] [MGI Ref ID J:108904]
Fujimura T; Suzuki H; Shimizu T; Tokui N; Kitamura T; Udaka T; Doi Y. 2005. Pathological alterations of strial capillaries in dominant white spotting W/Wv mice. Hear Res 209(1-2):53-9. [PubMed: 16054310] [MGI Ref ID J:102420]
Furuta T; Kikuchi T; Iwakura Y; Watanabe N. 2006. Protective roles of mast cells and mast cell-derived TNF in murine malaria. J Immunol 177(5):3294-302. [PubMed: 16920970] [MGI Ref ID J:139538]
Garcia RJ; Ittah A; Mirabal S; Figueroa J; Lopez L; Glick AB; Kos L. 2008. Endothelin 3 induces skin pigmentation in a keratin-driven inducible mouse model. J Invest Dermatol 128(1):131-42. [PubMed: 17611578] [MGI Ref ID J:129906]
Geissler EN; McFarland EC; Russell ES. 1981. Analysis of pleiotropism at the dominant white-spotting (W) locus of the house mouse: a description of ten new W alleles. Genetics 97(2):337-61. [PubMed: 7274658] [MGI Ref ID J:6571]
Godau J; Heller T; Hawlisch H; Trappe M; Howells E; Best J; Zwirner J; Verbeek JS; Hogarth PM; Gerard C; Van Rooijen N; Klos A; Gessner JE; Kohl J. 2004. C5a initiates the inflammatory cascade in immune complex peritonitis. J Immunol 173(5):3437-45. [PubMed: 15322209] [MGI Ref ID J:92709]
Green EL. 1968. . In: Handbook on Genetically Standardized Jax Mice. The Jackson Laboratory, Bar Harbor, ME. [MGI Ref ID J:36414]
Gregory GD; Raju SS; Winandy S; Brown MA. 2006. Mast cell IL-4 expression is regulated by Ikaros and influences encephalitogenic Th1 responses in EAE. J Clin Invest 116(5):1327-36. [PubMed: 16628252] [MGI Ref ID J:108943]
Gregory GD; Robbie-Ryan M; Secor VH; Sabatino JJ Jr; Brown MA. 2005. Mast cells are required for optimal autoreactive T cell responses in a murine model of multiple sclerosis. Eur J Immunol 35(12):3478-86. [PubMed: 16285014] [MGI Ref ID J:113769]
Grimbaldeston MA; Nakae S; Kalesnikoff J; Tsai M; Galli SJ. 2007. Mast cell-derived interleukin 10 limits skin pathology in contact dermatitis and chronic irradiation with ultraviolet B. Nat Immunol 8(10):1095-104. [PubMed: 17767162] [MGI Ref ID J:125267]
Gurish MF; Tao H; Abonia JP; Arya A; Friend DS; Parker CM; Austen KF. 2001. Intestinal mast cell progenitors require CD49dbeta7 (alpha4beta7 integrin) for tissue-specific homing. J Exp Med 194(9):1243-52. [PubMed: 11696590] [MGI Ref ID J:119138]
Hara M; Ono K; Hwang MW; Iwasaki A; Okada M; Nakatani K; Sasayama S; Matsumori A. 2002. Evidence for a role of mast cells in the evolution to congestive heart failure. J Exp Med 195(3):375-81. [PubMed: 11828013] [MGI Ref ID J:124826]
Heaney DL; Schulte BA. 2003. Dystroglycan expression in the mouse cochlea. Hear Res 177(1-2):12-20. [PubMed: 12618313] [MGI Ref ID J:108874]
Hida S; Tadachi M; Saito T; Taki S. 2005. Negative control of basophil expansion by IRF-2 critical for the regulation of Th1/Th2 balance. Blood 106(6):2011-7. [PubMed: 15914553] [MGI Ref ID J:118863]
Hirst GD; Beckett EA; Sanders KM; Ward SM. 2002. Regional variation in contribution of myenteric and intramuscular interstitial cells of Cajal to generation of slow waves in mouse gastric antrum. J Physiol 540(Pt 3):1003-12. [PubMed: 11986385] [MGI Ref ID J:105991]
Hochegger K; Siebenhaar F; Vielhauer V; Heininger D; Mayadas TN; Mayer G; Maurer M; Rosenkranz AR. 2005. Role of mast cells in experimental anti-glomerular basement membrane glomerulonephritis. Eur J Immunol 35(10):3074-82. [PubMed: 16180252] [MGI Ref ID J:113500]
Hossen MA; Fujii Y; Sugimoto Y; Kayasuga R; Kamei C. 2003. Histamine H3 receptors regulate vascular permeability changes in the skin of mast cell-deficient mice. Int Immunopharmacol 3(12):1563-8. [PubMed: 14555281] [MGI Ref ID J:106208]
Huizinga JD; Liu LW; Fitzpatrick A; White E; Gill S; Wang XY; Zarate N; Krebs L; Choi C; Starret T; Dixit D; Ye J. 2008. Deficiency of intramuscular ICC increases fundic muscle excitability but does not impede nitrergic innervation. Am J Physiol Gastrointest Liver Physiol 294(2):G589-94. [PubMed: 18096611] [MGI Ref ID J:132366]
Ingram DA; Wenning MJ; Shannon K; Clapp DW. 2003. Leukemic potential of doubly mutant Nf1 and Wv hematopoietic cells. Blood 101(5):1984-6. [PubMed: 12393498] [MGI Ref ID J:82128]
Ito A; Jippo T; Wakayama T; Morii E; Koma Y; Onda H; Nojima H; Iseki S; Kitamura Y. 2003. SgIGSF: a new mast-cell adhesion molecule used for attachment to fibroblasts and transcriptionally regulated by MITF. Blood 101(7):2601-8. [PubMed: 12456501] [MGI Ref ID J:115530]
Ito A; Koma Y; Watabe K; Jippo T; Wakayama T; Iseki S; Kitamura Y. 2004. Contribution of the SgIGSF adhesion molecule to survival of cultured mast cells in vivo. Biochem Biophys Res Commun 319(1):200-6. [PubMed: 15158462] [MGI Ref ID J:90387]
Ito CY; Li CY; Bernstein A; Dick JE; Stanford WL. 2003. Hematopoietic stem cell and progenitor defects in Sca-1/Ly-6A-null mice. Blood 101(2):517-23. [PubMed: 12393491] [MGI Ref ID J:81387]
Iyer AS; August A. 2008. The Tec family kinase, IL-2-inducible T cell kinase, differentially controls mast cell responses. J Immunol 180(12):7869-77. [PubMed: 18523250] [MGI Ref ID J:137249]
Jawdat DM; Rowden G; Marshall JS. 2006. Mast cells have a pivotal role in TNF-independent lymph node hypertrophy and the mobilization of Langerhans cells in response to bacterial peptidoglycan. J Immunol 177(3):1755-62. [PubMed: 16849485] [MGI Ref ID J:137976]
Johnson D; Yasui D; Seeldrayers P. 1991. An analysis of mast cell frequency in the rodent nervous system: numbers vary between different strains and can be reconstituted in mast cell-deficient mice. J Neuropathol Exp Neurol 50(3):227-34. [PubMed: 2022965] [MGI Ref ID J:121259]
Johnston DS; Russell LD; Friel PJ; Griswold MD. 2001. Murine germ cells do not require functional androgen receptors to complete spermatogenesis following spermatogonial stem cell transplantation. Endocrinology 142(6):2405-8. [PubMed: 11356688] [MGI Ref ID J:109878]
Jordan SA; Speed RM; Jackson IJ. 1999. Deficiency of Trp53 rescues the male fertility defects of Kit(W-v) mice but has no effect on the survival of melanocytes and mast cells. Dev Biol 215(1):78-90. [PubMed: 10525351] [MGI Ref ID J:58392]
Kaliss N. 1972. Transplanted tumors JAX Notes 410:. [MGI Ref ID J:22613]
Kanamaru Y; Scandiuzzi L; Essig M; Brochetta C; Guerin-Marchand C; Tomino Y; Monteiro RC; Peuchmaur M; Blank U. 2006. Mast cell-mediated remodeling and fibrinolytic activity protect against fatal glomerulonephritis. J Immunol 176(9):5607-15. [PubMed: 16622030] [MGI Ref ID J:131649]
Kanatsu-Shinohara M; Inoue K; Miki H; Ogonuki N; Takehashi M; Morimoto T; Ogura A; Shinohara T. 2006. Clonal origin of germ cell colonies after spermatogonial transplantation in mice. Biol Reprod 75(1):68-74. [PubMed: 16598026] [MGI Ref ID J:111774]
Kandere-Grzybowska K; Gheorghe D; Priller J; Esposito P; Huang M; Gerard N; Theoharides TC. 2003. Stress-induced dura vascular permeability does not develop in mast cell-deficient and neurokinin-1 receptor knockout mice. Brain Res 980(2):213-20. [PubMed: 12867261] [MGI Ref ID J:84660]
Karlsen TV; Bletsa A; Gjerde EA; Reed RK. 2007. Lowering of interstitial fluid pressure after neurogenic inflammation in mouse skin is partly dependent on mast cells. Am J Physiol Heart Circ Physiol 292(4):H1821-7. [PubMed: 17158654] [MGI Ref ID J:125823]
Kato M; Takeda K; Kawamoto Y; Tsuzuki T; Hossain K; Tamakoshi A; Kunisada T; Kambayashi Y; Ogino K; Suzuki H; Takahashi M; Nakashima I. 2004. c-Kit-Targeting Immunotherapy for Hereditary Melanoma in a Mouse Model. Cancer Res 64(3):801-6. [PubMed: 14871802] [MGI Ref ID J:88074]
Ketavarapu JM; Rodriguez AR; Yu JJ; Cong Y; Murthy AK; Forsthuber TG; Guentzel MN; Klose KE; Berton MT; Arulanandam BP. 2008. Mast cells inhibit intramacrophage Francisella tularensis replication via contact and secreted products including IL-4. Proc Natl Acad Sci U S A 105(27):9313-8. [PubMed: 18591675] [MGI Ref ID J:138191]
Kim YS; Ko HM; Kang NI; Song CH; Zhang X; Chung WC; Kim JH; Choi IH; Park YM; Kim GY; Im SY; Lee HK. 2007. Mast cells play a key role in the development of late airway hyperresponsiveness through TNF-alpha in a murine model of asthma. Eur J Immunol 37(4):1107-15. [PubMed: 17372990] [MGI Ref ID J:120842]
Kitamura Y; Go S. 1979. Decreased production of mast cells in S1/S1d anemic mice. Blood 53(3):492-7. [PubMed: 367470] [MGI Ref ID J:6084]
Kitamura Y; Yokoyama M; Matsuda H; Shimada M. 1980. Coincidental development of forestomach papilloma and prepyloric ulcer in nontreated mutant mice of W/Wv and SI/SId genotypes. Cancer Res 40(9):3392-7. [PubMed: 7000343] [MGI Ref ID J:6393]
Kobayashi T; Miura T; Haba T; Sato M; Serizawa I; Nagai H; Ishizaka K. 2000. An essential role of mast cells in the development of airway hyperresponsiveness in a murine asthma model. J Immunol 164(7):3855-61. [PubMed: 10725747] [MGI Ref ID J:61405]
Kolaczkowska E; Seljelid R; Plytycz B. 2001. Role of mast cells in zymosan-induced peritoneal inflammation in Balb/c and mast cell-deficient WBB6F1 mice. J Leukoc Biol 69(1):33-42. [PubMed: 11200065] [MGI Ref ID J:66995]
Kon Y; Endoh D; Iwanaga T. 1999. Expression of protein gene product 9.5, a neuronal ubiquitin C-terminal hydrolase, and its developing change in sertoli cells of mouse testis. Mol Reprod Dev 54(4):333-41. [PubMed: 10542373] [MGI Ref ID J:58391]
Koubova J; Menke DB; Zhou Q; Capel B; Griswold MD; Page DC. 2006. Retinoic acid regulates sex-specific timing of meiotic initiation in mice Proc Natl Acad Sci U S A 103(8):2474-9. [PubMed: 16461896] [MGI Ref ID J:107319]
Kraneveld AD; van der Kleij HP; Kool M; van Houwelingen AH; Weitenberg AC; Redegeld FA; Nijkamp FP. 2002. Key role for mast cells in nonatopic asthma. J Immunol 169(4):2044-53. [PubMed: 12165531] [MGI Ref ID J:120703]
Kraszucka K; Burfeind P; Nayernia K; Kohler M; Schmid M; Yaylaoglu M; Engel W. 1999. Developmental stage- and germ cell-regulated expression of a calcium-binding protein mRNA in mouse Sertoli cells. Mol Reprod Dev 54(3):232-43. [PubMed: 10497345] [MGI Ref ID J:57920]
Krishnamoorthy N; Oriss TB; Paglia M; Fei M; Yarlagadda M; Vanhaesebroeck B; Ray A; Ray P. 2008. Activation of c-Kit in dendritic cells regulates T helper cell differentiation and allergic asthma. Nat Med 14(5):565-73. [PubMed: 18454155] [MGI Ref ID J:136704]
Krishnamurthy M; Ayazi F; Li J; Lyttle AW; Woods M; Wu Y; Yee SP; Wang R. 2007. c-Kit in early onset of diabetes: a morphological and functional analysis of pancreatic beta-cells in c-KitW-v mutant mice. Endocrinology 148(11):5520-30. [PubMed: 17673521] [MGI Ref ID J:129945]
Kung TT; Stelts D; Zurcher JA; Jones H; Umland SP; Kreutner W; Egan RW; Chapman RW. 1995. Mast cells modulate allergic pulmonary eosinophilia in mice. Am J Respir Cell Mol Biol 12(4):404-9. [PubMed: 7695919] [MGI Ref ID J:25736]
Lantz CS; Boesiger J; Song CH; Mach N; Kobayashi T; Mulligan RC; Nawa Y; Dranoff G; Galli SJ. 1998. Role for interleukin-3 in mast-cell and basophil development and in immunity to parasites. Nature 392(6671):90-3. [PubMed: 9510253] [MGI Ref ID J:80500]
Lawrence CE; Paterson YY; Wright SH; Knight PA; Miller HR. 2004. Mouse mast cell protease-1 is required for the enteropathy induced by gastrointestinal helminth infection in the mouse. Gastroenterology 127(1):155-65. [PubMed: 15236182] [MGI Ref ID J:93616]
Lee DM; Friend DS; Gurish MF; Benoist C; Mathis D; Brenner MB. 2002. Mast cells: a cellular link between autoantibodies and inflammatory arthritis. Science 297(5587):1689-92. [PubMed: 12215644] [MGI Ref ID J:78906]
Li E; Zhou P; Petrin Z; Singer SM. 2004. Mast cell-dependent control of Giardia lamblia infections in mice. Infect Immun 72(11):6642-9. [PubMed: 15501797] [MGI Ref ID J:93272]
Li M; Liu K; Michalicek J; Angus JA; Hunt JE; Dell'Italia LJ; Feneley MP; Graham RM; Husain A. 2004. Involvement of chymase-mediated angiotensin II generation in blood pressure regulation. J Clin Invest 114(1):112-20. [PubMed: 15232618] [MGI Ref ID J:91374]
Lindsey JS; Wilkinson MF. 1996. Pem: a testosterone- and LH-regulated homeobox gene expressed in mouse Sertoli cells and epididymis. Dev Biol 179(2):471-84. [PubMed: 8903361] [MGI Ref ID J:36481]
Little CC; Cloudman AM. 1937. The occurrence of a dominant spotting mutation in the house mouse Proc Natl Acad Sci U S A 23(10):535-537. [PubMed: 16577810] [MGI Ref ID J:2447]
Lorenz U; Bergemann AD; Steinberg HN; Flanagan JG; Li X; Galli SJ; Neel BG. 1996. Genetic analysis reveals cell type-specific regulation of receptor tyrosine kinase c-Kit by the protein tyrosine phosphatase SHP1. J Exp Med 184(3):1111-26. [PubMed: 9064328] [MGI Ref ID J:35276]
Lourenssen S; Motro B; Bernstein A; Diamond J. 2000. Defects in sensory nerve numbers and growth in mutant Kit and Steel mice. Neuroreport 11(6):1159-65. [PubMed: 10817584] [MGI Ref ID J:103680]
Lyon MF; Glenister PH. 1982. A new allele sash (Wsh) at the W-locus and a spontaneous recessive lethal in mice. Genet Res 39(3):315-22. [PubMed: 7117838] [MGI Ref ID J:6857]
Mackarehtschian K; Hardin JD; Moore KA; Boast S; Goff SP; Lemischka IR. 1995. Targeted disruption of the flk2/flt3 gene leads to deficiencies in primitive hematopoietic progenitors. Immunity 3(1):147-61. [PubMed: 7621074] [MGI Ref ID J:27238]
Mackenzie MA; Jordan SA; Budd PS; Jackson IJ. 1997. Activation of the receptor tyrosine kinase Kit is required for the proliferation of melanoblasts in the mouse embryo. Dev Biol 192(1):99-107. [PubMed: 9405100] [MGI Ref ID J:97241]
Mackins CJ; Kano S; Seyedi N; Schafer U; Reid AC; Machida T; Silver RB; Levi R. 2006. Cardiac mast cell-derived renin promotes local angiotensin formation, norepinephrine release, and arrhythmias in ischemia/reperfusion. J Clin Invest 116(4):1063-70. [PubMed: 16585966] [MGI Ref ID J:107810]
Madden KB; Whitman L; Sullivan C; Gause WC; Urban JF Jr; Katona IM; Finkelman FD; Shea-Donohue T. 2002. Role of STAT6 and mast cells in IL-4- and IL-13-induced alterations in murine intestinal epithelial cell function. J Immunol 169(8):4417-22. [PubMed: 12370375] [MGI Ref ID J:120045]
Magnol L; Chevallier MC; Nalesso V; Retif S; Fuchs H; Klempt M; Pereira P; Riottot M; Andrzejewski S; Doan BT; Panthier JJ; Puech A; Beloeil JC; de Angelis MH; Herault Y. 2007. KIT is required for hepatic function during mouse post-natal development. BMC Dev Biol 7:81. [PubMed: 17612398] [MGI Ref ID J:125831]
Mak SS; Moriyama M; Nishioka E; Osawa M; Nishikawa S. 2006. Indispensable role of Bcl2 in the development of the melanocyte stem cell. Dev Biol 291(1):144-53. [PubMed: 16427619] [MGI Ref ID J:106370]
Makabe-Kobayashi Y; Hori Y; Adachi T; Ishigaki-Suzuki S; Kikuchi Y; Kagaya Y; Shirato K; Nagy A; Ujike A; Takai T; Watanabe T; Ohtsu H. 2002. The control effect of histamine on body temperature and respiratory function in IgE-dependent systemic anaphylaxis. J Allergy Clin Immunol 110(2):298-303. [PubMed: 12170272] [MGI Ref ID J:105816]
Malaviya R; Navara C; Uckun FM. 2001. Role of Janus kinase 3 in mast cell-mediated innate immunity against gram-negative bacteria. Immunity 15(2):313-21. [PubMed: 11520465] [MGI Ref ID J:111537]
Maurer M; Seidel-Guyenot W; Metz M; Knop J; Steinbrink K. 2003. Critical role of IL-10 in the induction of low zone tolerance to contact allergens. J Clin Invest 112(3):432-9. [PubMed: 12865418] [MGI Ref ID J:118509]
Maurer M; Wedemeyer J; Metz M; Piliponsky AM; Weller K; Chatterjea D; Clouthier DE; Yanagisawa MM; Tsai M; Galli SJ. 2004. Mast cells promote homeostasis by limiting endothelin-1-induced toxicity. Nature 432(7016):512-6. [PubMed: 15543132] [MGI Ref ID J:94154]
McLachlan JB; Hart JP; Pizzo SV; Shelburne CP; Staats HF; Gunn MD; Abraham SN. 2003. Mast cell-derived tumor necrosis factor induces hypertrophy of draining lymph nodes during infection. Nat Immunol 4(12):1199-205. [PubMed: 14595438] [MGI Ref ID J:86606]
McLachlan JB; Shelburne CP; Hart JP; Pizzo SV; Goyal R; Brooking-Dixon R; Staats HF; Abraham SN. 2008. Mast cell activators: a new class of highly effective vaccine adjuvants. Nat Med 14(5):536-41. [PubMed: 18425129] [MGI Ref ID J:136707]
Metz M; Piliponsky AM; Chen CC; Lammel V; Abrink M; Pejler G; Tsai M; Galli SJ. 2006. Mast cells can enhance resistance to snake and honeybee venoms. Science 313(5786):526-30. [PubMed: 16873664] [MGI Ref ID J:110940]
Mintz B; Klein-Szanto AJ. 1992. Malignancy of eye melanomas originating in the retinal pigment epithelium of transgenic mice after genetic ablation of choroidal melanocytes. Proc Natl Acad Sci U S A 89(23):11421-5. [PubMed: 1454829] [MGI Ref ID J:95743]
Miyajima I; Dombrowicz D; Martin TR; Ravetch JV; Kinet JP; Galli SJ. 1997. Systemic anaphylaxis in the mouse can be mediated largely through IgG1 and Fc gammaRIII. Assessment of the cardiopulmonary changes, mast cell degranulation, and death associated with active or IgE- or IgG1-dependent passive anaphylaxis. J Clin Invest 99(5):901-14. [PubMed: 9062348] [MGI Ref ID J:78659]
Miyata M; Hatsushika K; Ando T; Shimokawa N; Ohnuma Y; Katoh R; Suto H; Ogawa H; Masuyama K; Nakao A. 2008. Mast cell regulation of epithelial TSLP expression plays an important role in the development of allergic rhinitis. Eur J Immunol 38(6):1487-92. [PubMed: 18461563] [MGI Ref ID J:136211]
Miyazaki D; Nakamura T; Toda M; Cheung-Chau KW; Richardson RM; Ono SJ. 2005. Macrophage inflammatory protein-1alpha as a costimulatory signal for mast cell-mediated immediate hypersensitivity reactions. J Clin Invest 115(2):434-42. [PubMed: 15650768] [MGI Ref ID J:96185]
Moniruzzaman M; Sakamaki K; Akazawa Y; Miyano T. 2007. Oocyte growth and follicular development in KIT-deficient Fas-knockout mice. Reproduction 133(1):117-25. [PubMed: 17244738] [MGI Ref ID J:117783]
Moon BG; Takaki S; Miyake K; Takatsu K. 2004. The role of IL-5 for mature B-1 cells in homeostatic proliferation, cell survival, and Ig production. J Immunol 172(10):6020-9. [PubMed: 15128785] [MGI Ref ID J:89849]
Morii E; Ito A; Jippo T; Koma Y; Oboki K; Wakayama T; Iseki S; Lamoreux ML; Kitamura Y. 2004. Number of mast cells in the peritoneal cavity of mice: influence of microphthalmia transcription factor through transcription of newly found mast cell adhesion molecule, spermatogenic immunoglobulin superfamily. Am J Pathol 165(2):491-9. [PubMed: 15277223] [MGI Ref ID J:91476]
Morii E; Oboki K; Ishihara K; Jippo T; Hirano T; Kitamura Y. 2004. Roles of MITF for development of mast cells in mice: effects on both precursors and tissue environments. Blood 104(6):1656-61. [PubMed: 15172970] [MGI Ref ID J:92959]
Moriyama M; Sato T; Inoue H; Fukuyama S; Teranishi H; Kangawa K; Kano T; Yoshimura A; Kojima M. 2005. The neuropeptide neuromedin U promotes inflammation by direct activation of mast cells. J Exp Med 202(2):217-24. [PubMed: 16009716] [MGI Ref ID J:100520]
Mukai K; Matsuoka K; Taya C; Suzuki H; Yokozeki H; Nishioka K; Hirokawa K; Etori M; Yamashita M; Kubota T; Minegishi Y; Yonekawa H; Karasuyama H. 2005. Basophils play a critical role in the development of IgE-mediated chronic allergic inflammation independently of T cells and mast cells. Immunity 23(2):191-202. [PubMed: 16111637] [MGI Ref ID J:100537]
Mullaly SC; Kubes P. 2007. Mast cell-expressed complement receptor, not TLR2, is the main detector of zymosan in peritonitis. Eur J Immunol 37(1):224-34. [PubMed: 17154261] [MGI Ref ID J:117071]
Mullaly SC; Kubes P. 2006. The role of TLR2 in vivo following challenge with Staphylococcus aureus and prototypic ligands. J Immunol 177(11):8154-63. [PubMed: 17114491] [MGI Ref ID J:140680]
Murphy ED. 1966. Characteristic Tumors. In: Biology of the Laboratory Mouse. McGraw-Hill, New York. [MGI Ref ID J:24830]
Murphy ED; Beamer WG. 1973. Plasma gonadotropin levels during early stages of ovarian tumorigenesis in mice of the W x -W v genotype. Cancer Res 33(4):721-3. [PubMed: 4696472] [MGI Ref ID J:48589]
Muto S; Katsuki M; Horie S. 2007. Decreased c-kit function inhibits enhanced skin carcinogenesis in c-Ha-ras protooncogene transgenic mice. Cancer Sci 98(10):1549-56. [PubMed: 17683512] [MGI Ref ID J:138103]
Nakagawa T; Ueshima S; Fujii H; Nakajima Y; Takaki M. 2005. Different modulation of spontaneous activities by nitrergic inhibitory nerves between ileum and jejunum in W/Wv mutant mice. Auton Neurosci 119(1):25-35. [PubMed: 15893705] [MGI Ref ID J:101881]
Nakamura E; Kataoka T; Furutani K; Jimbo K; Aihara T; Tanaka S; Ichikawa A; Ohtsu H; Okabe S. 2004. Lack of histamine alters gastric mucosal morphology: comparison of histidine decarboxylase-deficient and mast cell-deficient mice. Am J Physiol Gastrointest Liver Physiol 287(5):G1053-61. [PubMed: 15271653] [MGI Ref ID J:96160]
Nguyen M; Pace AJ; Koller BH. 2005. Age-induced reprogramming of mast cell degranulation. J Immunol 175(9):5701-7. [PubMed: 16237060] [MGI Ref ID J:119387]
Nigo YI; Yamashita M; Hirahara K; Shinnakasu R; Inami M; Kimura M; Hasegawa A; Kohno Y; Nakayama T. 2006. Regulation of allergic airway inflammation through Toll-like receptor 4-mediated modification of mast cell function. Proc Natl Acad Sci U S A 103(7):2286-91. [PubMed: 16461458] [MGI Ref ID J:106067]
Nigrovic PA; Binstadt BA; Monach PA; Johnsen A; Gurish M; Iwakura Y; Benoist C; Mathis D; Lee DM. 2007. Mast cells contribute to initiation of autoantibody-mediated arthritis via IL-1. Proc Natl Acad Sci U S A 104(7):2325-30. [PubMed: 17277081] [MGI Ref ID J:119744]
Nocka K; Tan JC; Chiu E; Chu TY; Ray P; Traktman P; Besmer P. 1990. Molecular bases of dominant negative and loss of function mutations at the murine c-kit/white spotting locus: W37, Wv, W41 and W. EMBO J 9(6):1805-13. [PubMed: 1693331] [MGI Ref ID J:10528]
Norman MU; Hwang J; Hulliger S; Bonder CS; Yamanouchi J; Santamaria P; Kubes P. 2008. Mast cells regulate the magnitude and the cytokine microenvironment of the contact hypersensitivity response. Am J Pathol 172(6):1638-49. [PubMed: 18467702] [MGI Ref ID J:136229]
Novak EK; Hui SW; Swank RT. 1984. Platelet storage pool deficiency in mouse pigment mutations associated with seven distinct genetic loci. Blood 63(3):536-44. [PubMed: 6696991] [MGI Ref ID J:7327]
Oatley JM; Avarbock MR; Telaranta AI; Fearon DT; Brinster RL. 2006. Identifying genes important for spermatogonial stem cell self-renewal and survival. Proc Natl Acad Sci U S A 103(25):9524-9. [PubMed: 16740658] [MGI Ref ID J:111053]
Ogawa T; Dobrinski I; Avarbock MR; Brinster RL. 2000. Transplantation of male germ line stem cells restores fertility in infertile mice [see comments] Nat Med 6(1):29-34. [PubMed: 10613820] [MGI Ref ID J:59322]
Ohta H; Tohda A; Nishimune Y. 2003. Proliferation and differentiation of spermatogonial stem cells in the w/wv mutant mouse testis. Biol Reprod 69(6):1815-21. [PubMed: 12890724] [MGI Ref ID J:108583]
Ohta H; Yomogida K; Dohmae K; Nishimune Y. 2000. Regulation of proliferation and differentiation in spermatogonial stem cells: the role of c-kit and its ligand SCF Development 127(10):2125-31. [PubMed: 10769236] [MGI Ref ID J:61520]
Orinska Z; Bulanova E; Budagian V; Metz M; Maurer M; Bulfone-Paus S. 2005. TLR3-induced activation of mast cells modulates CD8+ T-cell recruitment. Blood 106(3):978-87. [PubMed: 15840693] [MGI Ref ID J:117318]
Orinska Z; Maurer M; Mirghomizadeh F; Bulanova E; Metz M; Nashkevich N; Schiemann F; Schulmistrat J; Budagian V; Giron-Michel J; Brandt E; Paus R; Bulfone-Paus S. 2007. IL-15 constrains mast cell-dependent antibacterial defenses by suppressing chymase activities. Nat Med 13(8):927-34. [PubMed: 17643110] [MGI Ref ID J:125124]
Ottolenghi C; Pelosi E; Tran J; Colombino M; Douglass E; Nedorezov T; Cao A; Forabosco A; Schlessinger D. 2007. Loss of Wnt4 and Foxl2 leads to female-to-male sex reversal extending to germ cells. Hum Mol Genet 16(23):2795-804. [PubMed: 17728319] [MGI Ref ID J:129972]
Paulson RF; Vesely S; Siminovitch KA; Bernstein A. 1996. Signalling by the W/Kit receptor tyrosine kinase is negatively regulated in vivo by the protein tyrosine phosphatase Shp1. Nat Genet 13(3):309-15. [PubMed: 8673130] [MGI Ref ID J:34290]
Perez-Losada J; Sanchez-Martin M; Rodriguez-Garcia A; Sanchez ML; Orfao A; Flores T; Sanchez-Garcia I. 2002. Zinc-finger transcription factor Slug contributes to the function of the stem cell factor c-kit signaling pathway. Blood 100(4):1274-86. [PubMed: 12149208] [MGI Ref ID J:78323]
Piliponsky AM; Chen CC; Nishimura T; Metz M; Rios EJ; Dobner PR; Wada E; Wada K; Zacharias S; Mohanasundaram UM; Faix JD; Abrink M; Pejler G; Pearl RG; Tsai M; Galli SJ. 2008. Neurotensin increases mortality and mast cells reduce neurotensin levels in a mouse model of sepsis. Nat Med 14(4):392-8. [PubMed: 18376408] [MGI Ref ID J:133676]
Pusch W; Jahner D; Ivell R. 1998. Molecular cloning and testicular expression of the gene transcripts encoding the murine multiubiquitin-chain-binding protein (Mcb1). Gene 207(1):19-24. [PubMed: 9511739] [MGI Ref ID J:45944]
RUSSELL ES. 1949. Analysis of pleiotropism at the W-locus in the mouse; relationship between the effects of W and Wv substitution on hair pigmentation and on erythrocytes. Genetics 34(6):708-23. [PubMed: 15393917] [MGI Ref ID J:3400]
Rabionet M; van der Spoel AC; Chuang CC; von Tumpling-Radosta B; Litjens M; Bouwmeester D; Hellbusch CC; Korner C; Wiegandt H; Gorgas K; Platt FM; Grone HJ; Sandhoff R. 2008. Male germ cells require polyenoic sphingolipids with complex glycosylation for completion of meiosis: a link to ceramide synthase-3. J Biol Chem 283(19):13357-69. [PubMed: 18308723] [MGI Ref ID J:137091]
Reil JC; Gilles S; Zahler S; Brandl A; Drexler H; Hultner L; Matrisian LM; Welsch U; Becker BF. 2007. Insights from knock-out models concerning postischemic release of TNFalpha from isolated mouse hearts. J Mol Cell Cardiol 42(1):133-41. [PubMed: 17101148] [MGI Ref ID J:119661]
Rijnierse A; Koster AS; Nijkamp FP; Kraneveld AD. 2006. Critical role for mast cells in the pathogenesis of 2,4-dinitrobenzene-induced murine colonic hypersensitivity reaction. J Immunol 176(7):4375-84. [PubMed: 16547276] [MGI Ref ID J:129893]
Rocchi R; Kimura H; Tzou SC; Suzuki K; Rose NR; Pinchera A; Ladenson PW; Caturegli P. 2007. Toll-like receptor-MyD88 and Fc receptor pathways of mast cells mediate the thyroid dysfunctions observed during nonthyroidal illness. Proc Natl Acad Sci U S A 104(14):6019-24. [PubMed: 17389381] [MGI Ref ID J:120373]
Rosenblatt-Velin N; Lepore MG; Cartoni C; Beermann F; Pedrazzini T. 2005. FGF-2 controls the differentiation of resident cardiac precursors into functional cardiomyocytes. J Clin Invest 115(7):1724-33. [PubMed: 15951838] [MGI Ref ID J:99644]
Ross AJ; Amy SP; Mahar PL; Lindsten T; Knudson CM; Thompson CB; Korsmeyer SJ; MacGregor GR. 2001. BCLW Mediates Survival of Postmitotic Sertoli Cells by Regulating BAX Activity. Dev Biol 239(2):295-308. [PubMed: 11784036] [MGI Ref ID J:72582]
Russell ES; Bernstein SE. 1966. Blood and Blood Formation. In: Biology of the Laboratory Mouse. McGraw Hill, New York. [MGI Ref ID J:24829]
Russell JS; McGee SO; Ip MM; Kuhlmann D; Masso-Welch PA. 2007. Conjugated linoleic acid induces mast cell recruitment during mouse mammary gland stromal remodeling. J Nutr 137(5):1200-7. [PubMed: 17449582] [MGI Ref ID J:121742]
Sakata S; Sakamaki K; Watanabe K; Nakamura N; Toyokuni S; Nishimune Y; Mori C; Yonehara S. 2003. Involvement of death receptor Fas in germ cell degeneration in gonads of Kit-deficient Wv/Wv mutant mice. Cell Death Differ 10(6):676-86. [PubMed: 12761576] [MGI Ref ID J:115715]
Sanchez-Martin M; Rodriguez-Garcia A; Perez-Losada J; Sagrera A; Read AP; Sanchez-Garcia I. 2002. SLUG (SNAI2) deletions in patients with Waardenburg disease. Hum Mol Genet 11(25):3231-6. [PubMed: 12444107] [MGI Ref ID J:80529]
Sarna SK. 2008. Are interstitial cells of Cajal plurifunction cells in the gut? Am J Physiol Gastrointest Liver Physiol 294(2):G372-90. [PubMed: 17932226] [MGI Ref ID J:132097]
Sasaki Y; Yoshimoto T; Maruyama H; Tegoshi T; Ohta N; Arizono N; Nakanishi K. 2005. IL-18 with IL-2 protects against Strongyloides venezuelensis infection by activating mucosal mast cell-dependent type 2 innate immunity. J Exp Med 202(5):607-16. [PubMed: 16129701] [MGI Ref ID J:100697]
Sassa S; Bernstein SE. 1978. Studies of erythrocyte protoporphyrin in anemic mutant mice: use of a modified hematofluorometer for the detection of heterozygotes for hemolytic disease. Exp Hematol 6(5):479-87. [PubMed: 658175] [MGI Ref ID J:5985]
Schneider LA; Schlenner SM; Feyerabend TB; Wunderlin M; Rodewald HR. 2007. Molecular mechanism of mast cell mediated innate defense against endothelin and snake venom sarafotoxin. J Exp Med 204(11):2629-39. [PubMed: 17923505] [MGI Ref ID J:125964]
Secor VH; Secor WE; Gutekunst CA; Brown MA. 2000. Mast cells are essential for early onset and severe disease in a murine model of multiple sclerosis. J Exp Med 191(5):813-22. [PubMed: 10704463] [MGI Ref ID J:60917]
Serizawa I; Koezuka Y; Amao H; Saito TR; Takahashi KW. 2000. Functional natural killer T cells in experimental mouse strains, including NK1.1- strains Exp Anim 49(3):171-80. [PubMed: 11109539] [MGI Ref ID J:64139]
Sha L; Farrugia G; Harmsen WS; Szurszewski JH. 2007. Membrane potential gradient is carbon monoxide-dependent in mouse and human small intestine. Am J Physiol Gastrointest Liver Physiol 293(2):G438-45. [PubMed: 17510199] [MGI Ref ID J:125239]
Sharkis SJ; Wiktor-Jedrzejczak W; Ahmed A; Santos GW; McKee A; Sell KW. 1978. Antitheta-sensitive regulatory cell (TSRC) and hematopoiesis: regulation of differentiation of transplanted stem cells in W/Wv anemic and normal mice. Blood 52(4):802-17. [PubMed: 28803] [MGI Ref ID J:6030]
Sharma Y; Astle CM; Harrison DE. 2007. Heterozygous kit mutants with little or no apparent anemia exhibit large defects in overall hematopoietic stem cell function. Exp Hematol 35(2):214-220. [PubMed: 17258070] [MGI Ref ID J:123190]
Siebenhaar F; Syska W; Weller K; Magerl M; Zuberbier T; Metz M; Maurer M. 2007. Control of Pseudomonas aeruginosa skin infections in mice is mast cell-dependent. Am J Pathol 170(6):1910-6. [PubMed: 17525259] [MGI Ref ID J:122101]
Silvers WK. 1979. The Coat Colors of Mice; A Model for Mammalian Gene Action and Interaction. In: The Coat Colors of Mice. Springer-Verlag, New York. [MGI Ref ID J:78801]
Sivarao DV; Mashimo HL; Thatte HS; Goyal RK. 2001. Lower esophageal sphincter is achalasic in nNOS(-/-) and hypotensive in W/W(v) mutant mice. Gastroenterology 121(1):34-42. [PubMed: 11438492] [MGI Ref ID J:70182]
Sokol CL; Barton GM; Farr AG; Medzhitov R. 2008. A mechanism for the initiation of allergen-induced T helper type 2 responses. Nat Immunol 9(3):310-8. [PubMed: 18300366] [MGI Ref ID J:131552]
Sterbing SJ; Schrott-Fischer A. 2002. Electrophysiological characteristics of inferior colliculus neurons in mutant mice with hereditary absence of cochlear outer hair cells. Hear Res 170(1-2):179-89. [PubMed: 12208551] [MGI Ref ID J:108899]
Stokol T; O'Donnell P; Xiao L; Knight S; Stavrakis G; Botto M; von Andrian UH; Mayadas TN. 2004. C1q governs deposition of circulating immune complexes and leukocyte Fcgamma receptors mediate subsequent neutrophil recruitment. J Exp Med 200(7):835-46. [PubMed: 15466618] [MGI Ref ID J:93949]
Strait RT; Morris SC; Finkelman FD. 2006. IgG-blocking antibodies inhibit IgE-mediated anaphylaxis in vivo through both antigen interception and Fc gamma RIIb cross-linking. J Clin Invest 116(3):833-41. [PubMed: 16498503] [MGI Ref ID J:106571]
Subramanian A; Teal HE; Correll PH; Paulson RF. 2005. Resistance to friend virus-induced erythroleukemia in W/W(v) mice is caused by a spleen-specific defect which results in a severe reduction in target cells and a lack of Sf-Stk expression. J Virol 79(23):14586-94. [PubMed: 16282458] [MGI Ref ID J:102884]
Sugihara A; Tsujimura T; Fujita Y; Nakata Y; Terada N. 1999. Evaluation of role of mast cells in the development of liver fibrosis using mast cell-deficient rats and mice. J Hepatol 30(5):859-67. [PubMed: 10365813] [MGI Ref ID J:57192]
Suto H; Nakae S; Kakurai M; Sedgwick JD; Tsai M; Galli SJ. 2006. Mast cell-associated TNF promotes dendritic cell migration. J Immunol 176(7):4102-12. [PubMed: 16547246] [MGI Ref ID J:129877]
Suzuki M; Nakano K. 1996. Increase in histamine synthesis by liver macrophages in CCl4-injured mast cell-deficient W/Wv mice. Biochem Pharmacol 52(5):809-13. [PubMed: 8765479] [MGI Ref ID J:35601]
Takayama I; Daigo Y; Ward SM; Sanders KM; Walker RL; Horowitz B; Yamanaka T; Fujino MA. 2002. Novel human and mouse genes encoding an acid phosphatase family member and its downregulation in W/W(V) mouse jejunum. Gut 50(6):790-6. [PubMed: 12010880] [MGI Ref ID J:103263]
Tang H; Ross A; Capel B. 2008. Expression and functional analysis of Gm114, a putative mammalian ortholog of Drosophila bam. Dev Biol 318(1):73-81. [PubMed: 18423593] [MGI Ref ID J:136802]
Taube C; Miyahara N; Ott V; Swanson B; Takeda K; Loader J; Shultz LD; Tager AM; Luster AD; Dakhama A; Gelfand EW. 2006. The leukotriene B4 receptor (BLT1) is required for effector CD8+ T cell-mediated, mast cell-dependent airway hyperresponsiveness. J Immunol 176(5):3157-64. [PubMed: 16493075] [MGI Ref ID J:129412]
Tavener SA; Kubes P. 2006. Cellular and molecular mechanisms underlying LPS-associated myocyte impairment. Am J Physiol Heart Circ Physiol 290(2):H800-6. [PubMed: 16172157] [MGI Ref ID J:106721]
Tennent BJ; Beamer WG. 1986. Ovarian tumors not induced by irradiation and gonadotropins in hypogonadal (hpg) mice. Biol Reprod 34(4):751-60. [PubMed: 3708055] [MGI Ref ID J:48591]
Thuneberg L; Peters S. 2001. Toward a concept of stretch-coupling in smooth muscle. I. Anatomy of intestinal segmentation and sleeve contractions. Anat Rec 262(1):110-24. [PubMed: 11146434] [MGI Ref ID J:66959]
Tilley SL; Tsai M; Williams CM; Wang ZS; Erikson CJ; Galli SJ; Koller BH. 2003. Identification of A3 receptor- and mast cell-dependent and -independent components of adenosine-mediated airway responsiveness in mice. J Immunol 171(1):331-7. [PubMed: 12817015] [MGI Ref ID J:123463]
Tokuda M; Kadokawa Y; Kurahashi H; Marunouchi T. 2007. CDH1 is a specific marker for undifferentiated spermatogonia in mouse testes. Biol Reprod 76(1):130-41. [PubMed: 17035642] [MGI Ref ID J:117360]
Tsujimura T; Koshimizu U; Katoh H; Isozaki K; Kanakura Y; Tono T; Adachi S; Kasugai T; Tei H; Nishimune Y; Nomura S; Kitamura Y. 1993. Mast cell number in the skin of heterozygotes reflects the molecular nature of c-kit mutation. Blood 81(10):2530-8. [PubMed: 7683920] [MGI Ref ID J:27513]
Tsujimura Y; Obata K; Mukai K; Shindou H; Yoshida M; Nishikado H; Kawano Y; Minegishi Y; Shimizu T; Karasuyama H. 2008. Basophils play a pivotal role in immunoglobulin-G-mediated but not immunoglobulin-E-mediated systemic anaphylaxis. Immunity 28(4):581-9. [PubMed: 18342553] [MGI Ref ID J:134463]
Van Raamsdonk CD; Fitch KR; Fuchs H; de Angelis MH; Barsh GS. 2004. Effects of G-protein mutations on skin color. Nat Genet 36(9):961-8. [PubMed: 15322542] [MGI Ref ID J:92947]
Wang CH; Anderson N; Li SH; Szmitko PE; Cherng WJ; Fedak PW; Fazel S; Li RK; Yau TM; Weisel RD; Stanford WL; Verma S. 2006. Stem cell factor deficiency is vasculoprotective: unraveling a new therapeutic potential of imatinib mesylate. Circ Res 99(6):617-25. [PubMed: 16931795] [MGI Ref ID J:125065]
Wedemeyer J; Galli SJ. 2005. Decreased susceptibility of mast cell-deficient Kit(W)/Kit(W-v) mice to the development of 1, 2-dimethylhydrazine-induced intestinal tumors. Lab Invest 85(3):388-96. [PubMed: 15696191] [MGI Ref ID J:96368]
Wei OL; Hilliard A; Kalman D; Sherman M. 2005. Mast cells limit systemic bacterial dissemination but not colitis in response to Citrobacter rodentium. Infect Immun 73(4):1978-85. [PubMed: 15784538] [MGI Ref ID J:97208]
Weller K; Foitzik K; Paus R; Syska W; Maurer M. 2006. Mast cells are required for normal healing of skin wounds in mice. FASEB J 20(13):2366-8. [PubMed: 16966487] [MGI Ref ID J:129739]
Wershil BK; Castagliuolo I; Pothoulakis C. 1998. Direct evidence of mast cell involvement in Clostridium difficile toxin A-induced enteritis in mice. Gastroenterology 114(5):956-64. [PubMed: 9558284] [MGI Ref ID J:107762]
Wershil BK; Theodos CM; Galli SJ; Titus RG. 1994. Mast cells augment lesion size and persistence during experimental Leishmania major infection in the mouse. J Immunol 152(9):4563-71. [PubMed: 8157970] [MGI Ref ID J:17706]
Williams CM; Galli SJ. 2000. Mast cells can amplify airway reactivity and features of chronic inflammation in an asthma model in mice. J Exp Med 192(3):455-62. [PubMed: 10934234] [MGI Ref ID J:63872]
Won KJ; Sanders KM; Ward SM. 2005. Interstitial cells of Cajal mediate mechanosensitive responses in the stomach. Proc Natl Acad Sci U S A 102(41):14913-8. [PubMed: 16204383] [MGI Ref ID J:102473]
Wouters M; De Laet A; Donck LV; Delpire E; van Bogaert PP; Timmermans JP; de Kerchove d'Exaerde A; Smans K; Vanderwinden JM. 2006. Subtractive hybridization unravels a role for the ion cotransporter NKCC1 in the murine intestinal pacemaker. Am J Physiol Gastrointest Liver Physiol 290(6):G1219-27. [PubMed: 16123204] [MGI Ref ID J:111089]
Yamaguchi N; Sugita R; Miki A; Takemura N; Kawabata J; Watanabe J; Sonoyama K. 2006. Gastrointestinal Candida colonisation promotes sensitisation against food antigens by affecting the mucosal barrier in mice. Gut 55(7):954-60. [PubMed: 16423887] [MGI Ref ID J:135817]
Yang WL; Cai KQ; Smedberg JL; Smith ER; Klein-Szanto A; Hamilton TC; Xu XX. 2007. A reduction of cyclooxygenase 2 gene dosage counters the ovarian morphological aging and tumor phenotype in Wv mice. Am J Pathol 170(4):1325-36. [PubMed: 17392171] [MGI Ref ID J:120134]
Yokozeki H; Wu MH; Sumi K; Igawa K; Miyazaki Y; Katayama I; Takeda K; Akira S; Nishioka K. 2003. Th2 cytokines, IgE and mast cells play a crucial role in the induction of para-phenylenediamine-induced contact hypersensitivity in mice. Clin Exp Immunol 132(3):385-92. [PubMed: 12780683] [MGI Ref ID J:83737]
Yomogida K; Ohtani H; Harigae H; Ito E; Nishimune Y; Engel JD; Yamamoto M. 1994. Developmental stage- and spermatogenic cycle-specific expression of transcription factor GATA-1 in mouse Sertoli cells. Development 120(7):1759-66. [PubMed: 7924983] [MGI Ref ID J:19188]
Yoshida S; Sukeno M; Nakagawa T; Ohbo K; Nagamatsu G; Suda T; Nabeshima Y. 2006. The first round of mouse spermatogenesis is a distinctive program that lacks the self-renewing spermatogonia stage. Development 133(8):1495-505. [PubMed: 16540512] [MGI Ref ID J:107419]
Yu M; Tsai M; Tam SY; Jones C; Zehnder J; Galli SJ. 2006. Mast cells can promote the development of multiple features of chronic asthma in mice. J Clin Invest 116(6):1633-41. [PubMed: 16710480] [MGI Ref ID J:110366]
Zhao M; Rohozinski J; Sharma M; Ju J; Braun RE; Bishop CE; Meistrich ML. 2007. Utp14b: a unique retrogene within a gene that has acquired multiple promoters and a specific function in spermatogenesis. Dev Biol 304(2):848-59. [PubMed: 17291484] [MGI Ref ID J:122508]
Zhou JS; Xing W; Friend DS; Austen KF; Katz HR. 2007. Mast cell deficiency in Kit(W-sh) mice does not impair antibody-mediated arthritis. J Exp Med 204(12):2797-802. [PubMed: 17998392] [MGI Ref ID J:128512]
oRdog T; Baldo M; Danko R; Sanders KM. 2002. Plasticity of electrical pacemaking by interstitial cells of Cajal and gastric dysrhythmias in W/W mutant mice. Gastroenterology 123(6):2028-40. [PubMed: 12454859] [MGI Ref ID J:80620]
van Buul PP; Tuinenburg-Bol Raap A; Goudzwaard HJ; Seelen CM; Beechey CV; Natarajan AT; Searle AG. 1991. Cytogenetic characterization of radiosensitive mouse mutants. Mutat Res 251(2):171-9. [PubMed: 1720867] [MGI Ref ID J:4646]
Carter TC. 1951. The genetics of luxate mice. I. Morphological abnormalities of heterozygotes and homozygotes. J Genet 50:277-299. [MGI Ref ID J:13039]
Carter TC. 1953. The genetics of luxate mice. III. Horseshoe kidney, hydronephrosis and lumbar reduction. J Genet 51(3):443-457. [MGI Ref ID J:13044]
Carter TC. 1954. The genetics of luxate mice. IV. Embryology J Genet 52:1-35. [MGI Ref ID J:14981]
Dagg CP. 1967. Combined action of fluorouracil and two mutant genes on limb development in the mouse. J Exp Zool 164(3):479-89. [PubMed: 6068186] [MGI Ref ID J:5039]
Long SY; Johnson EM. 1968. Enzyme ontogeny in normal and hemimelic limbs of mice. J Embryol Exp Morphol 20(3):415-30. [PubMed: 4302544] [MGI Ref ID J:5097]
Masuya H; Sagai T; Moriwaki K; Shiroishi T. 1997. Multigenic control of the localization of the zone of polarizing activity in limb morphogenesis in the mouse. Dev Biol 182(1):42-51. [PubMed: 9073443] [MGI Ref ID J:38196]
Searle AG. 1964. The genetics and morphology of two 'luxoid' mutants in the house mouse Genet Res 5:171-197. [MGI Ref ID J:112]
Yada Y; Makino S; Chigusa-Ishiwa S; Shiroishi T. 2002. The mouse polydactylous mutation, luxate (lx), causes anterior shift of the anteroposterior border in the developing hindlimb bud. Int J Dev Biol 46(7):975-82. [PubMed: 12455637] [MGI Ref ID J:81331]
Health & husbandry
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Pricing
| Pricing for USA, Canada and Mexico shipping destinations |
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*Price(s) in US dollars ($)
Weeks of Age Price* Gender Cryorecovery Fee $1900.00
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*Price(s) in US dollars ($)
Weeks of Age Price* Gender Cryorecovery Fee $2470.00
Additional Supply Details
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Supply Details
| Standard Supply | Repository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information. |
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| Supply Notes |
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Control Information
| Control | ||
|---|---|---|
| Untyped from the colony | ||
| Wild-type from the colony | ||
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
| USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
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