Strain Name:

B6.Cg-Lx KitW-v/J

Stock Number:

000194

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Availability:

Cryopreserved - Ready for recovery

Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Former Names C57BL/6J-Lx KitW-v/J    (Changed: 15-DEC-04 )
Type Congenic; Mutant Strain;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Additional information on Congenic nomenclature.
Specieslaboratory mouse
GenerationN109p
Generation Definitions

Description
Kit mice possess pleiotropic defects in pigment-forming cells, germ cells, RBC's and mast cells. In addition, they exhibit impaired resistance to parasitic infection and an intrinsic progenitor cell defect. KitW-v homozygotes resemble KitW homozygotes in color, anemia, and germ cells, but many of them survive to maturity. The lack of germ cells in mutant mice leads to the development of some ovarian tumors (mesotheliomas and granulosa cell), associated with an overproduction of pituitary gonadotropic hormone. Heterozygous lx mice show preaxial polydactyly (including hyperphalangy of the first digit) of the hindfeet. Homozygotes show preaxial polydactyly or oligodactyly of the hindfeet, reduction of the tibia, loss of part of the femur and pubis, decrease in number of presacral vertebrae, and anomalies of the urogenital system including horseshoe kidney, hydronephrosis, and hydroureter.

Although homozygous KitW-v/KitW-v have been described as being viable, Dr. Jane Barker of The Jackson Laboratory has found that in her colony C57BL/6J-KitW-v homozygotes die at birth or soon thereafter.

Control Information

  Control
   Untyped from the colony
   Wild-type from the colony
   000664 C57BL/6J
 
  Considerations for Choosing Controls

Related Strains

Strains carrying   KitW-v allele
016588   A.B6-KitW-v/BeiMmjax
000599   B6 x B6CBCa Aw-J/A-T(5;13)264Ca KitW-v/J
000350   B6By.Cg-KitW-v MitfMi-wh T/J
000049   C57BL/6J-KitW-v/J
100410   WBB6F1/J-KitW/KitW-v/J
View Strains carrying   KitW-v     (5 strains)

View Strains carrying other alleles of Kit     (37 strains)

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested.
Gastrointestinal Stromal Tumor; GIST   (KIT)
Mast Cell Disease   (KIT)
Piebald Trait; PBT   (KIT)
Testicular Germ Cell Tumor; TGCT   (KIT)
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

KitW-v/Kit+

        involves: C57BL/6
  • hematopoietic system phenotype
  • macrocytic anemia
    • slightly macrocytic   (MGI Ref ID J:3400)

KitW-v/Kit+

        involves: C57BL * C57BL/6
  • immune system phenotype
  • decreased mast cell number
    • mice exhibit fewer mast cells in the skin than wild-type mice   (MGI Ref ID J:27513)
  • hematopoietic system phenotype
  • decreased erythrocyte cell number   (MGI Ref ID J:27513)
  • decreased mast cell number
    • mice exhibit fewer mast cells in the skin than wild-type mice   (MGI Ref ID J:27513)
  • pigmentation phenotype
  • diluted coat color   (MGI Ref ID J:27513)
  • white spotting   (MGI Ref ID J:27513)
  • integument phenotype
  • diluted coat color   (MGI Ref ID J:27513)
  • white spotting   (MGI Ref ID J:27513)

KitW-v/Kit+

        Background Not Specified
  • integument phenotype
  • abnormal coat/hair pigmentation
    • variable amounts of white spotting   (MGI Ref ID J:2447)
    • slightly diluted coat color   (MGI Ref ID J:2447)
    • diluted coat color   (MGI Ref ID J:2447)
    • variable body spotting   (MGI Ref ID J:2447)
  • pigmentation phenotype
  • abnormal coat/hair pigmentation
    • variable amounts of white spotting   (MGI Ref ID J:2447)
    • slightly diluted coat color   (MGI Ref ID J:2447)
    • diluted coat color   (MGI Ref ID J:2447)
    • variable body spotting   (MGI Ref ID J:2447)
  • reproductive system phenotype
  • *normal* reproductive system phenotype   (MGI Ref ID J:2447)

KitW-v/Kit+

        involves: C57BL * DBA
  • pigmentation phenotype
  • belly spot
    • a spot is always present on the belly   (MGI Ref ID J:125080)
  • diluted coat color   (MGI Ref ID J:125080)
  • head spot
    • a head spot frequently but not always occurs   (MGI Ref ID J:125080)
  • hematopoietic system phenotype
  • macrocytic anemia
    • mild macrocytic anemia   (MGI Ref ID J:125080)
  • integument phenotype
  • belly spot
    • a spot is always present on the belly   (MGI Ref ID J:125080)
  • diluted coat color   (MGI Ref ID J:125080)
  • head spot
    • a head spot frequently but not always occurs   (MGI Ref ID J:125080)

KitW-v/Kit+

        involves: C57BL
  • integument phenotype
  • abnormal coat/hair pigmentation
    • variable amount of white spotting   (MGI Ref ID J:2447)
    • slightly diluted coat color   (MGI Ref ID J:2447)
  • pigmentation phenotype
  • abnormal coat/hair pigmentation
    • variable amount of white spotting   (MGI Ref ID J:2447)
    • slightly diluted coat color   (MGI Ref ID J:2447)
  • reproductive system phenotype
  • *normal* reproductive system phenotype
    • fertile   (MGI Ref ID J:2447)

KitW-v/KitW-v

        involves: C57BL/6
  • hematopoietic system phenotype
  • macrocytic anemia   (MGI Ref ID J:3400)
  • homeostasis/metabolism phenotype
  • increased bleeding time
    • bleed time of 6.9 minutes on average after tail nick is longer than the 3.8 minutes in C57BL/6J controls   (MGI Ref ID J:7327)

KitW-v/KitW-v

        involves: CBA/Ca
  • hearing/vestibular/ear phenotype
  • abnormal ear pigmentation
    • about half of the pinnae are pigmented and 21% of inner ears show some pigmentation of the vestibular region   (MGI Ref ID J:4062)
    • no strial pigmentation in mutants that lack an endocochlear potential   (MGI Ref ID J:4062)
  • abnormal stria vascularis morphology   (MGI Ref ID J:4062)
    • abnormal stria vascularis vasculature morphology
      • the capillary network is poorly developed   (MGI Ref ID J:4062)
    • abnormal strial basal cell morphology
      • basal cells have no cytoplasmic projections   (MGI Ref ID J:4062)
      • basal cells of the stria vascularis do not contain premelanosomes or melanosomes   (MGI Ref ID J:4062)
    • abnormal strial marginal cell morphology
      • marginal cells have poorly developed basolateral projections   (MGI Ref ID J:4062)
    • absent strial intermediate cells
      • no pigment is present   (MGI Ref ID J:4062)
      • 89% lack melanocytes within the stria vascularis   (MGI Ref ID J:4062)
    • thin stria vascularis
      • strias are noticeably thinner and are reduced to a two-layered tissue composed only of marginal and basal cells   (MGI Ref ID J:4062)
  • absent endocochlear potential
    • 89% of homozygous mutants lack an endocochlear potential   (MGI Ref ID J:4062)
  • pigmentation phenotype
  • abnormal ear pigmentation
    • about half of the pinnae are pigmented and 21% of inner ears show some pigmentation of the vestibular region   (MGI Ref ID J:4062)
    • no strial pigmentation in mutants that lack an endocochlear potential   (MGI Ref ID J:4062)
  • abnormal melanocyte morphology
    • no melanocytes detected in dorsal skin or in hair follicles   (MGI Ref ID J:4062)
    • abnormal melanosome morphology
      • in mutants that do have endocochlear potential, melanin granules were rarely observed and no melanosomes were detected in marginal or basal cells   (MGI Ref ID J:4062)
    • absent strial intermediate cells
      • no pigment is present   (MGI Ref ID J:4062)
      • 89% lack melanocytes within the stria vascularis   (MGI Ref ID J:4062)
  • cardiovascular system phenotype
  • abnormal stria vascularis vasculature morphology
    • the capillary network is poorly developed   (MGI Ref ID J:4062)
  • craniofacial phenotype
  • abnormal ear pigmentation
    • about half of the pinnae are pigmented and 21% of inner ears show some pigmentation of the vestibular region   (MGI Ref ID J:4062)
    • no strial pigmentation in mutants that lack an endocochlear potential   (MGI Ref ID J:4062)
  • integument phenotype
  • abnormal ear pigmentation
    • about half of the pinnae are pigmented and 21% of inner ears show some pigmentation of the vestibular region   (MGI Ref ID J:4062)
    • no strial pigmentation in mutants that lack an endocochlear potential   (MGI Ref ID J:4062)
  • growth/size/body phenotype
  • abnormal ear pigmentation
    • about half of the pinnae are pigmented and 21% of inner ears show some pigmentation of the vestibular region   (MGI Ref ID J:4062)
    • no strial pigmentation in mutants that lack an endocochlear potential   (MGI Ref ID J:4062)

Lx/Lx

        involves: fancier's silver mouse
  • mortality/aging
  • partial postnatal lethality
    • some mice fail to thrive and die prior to weaning   (MGI Ref ID J:13039)
  • reproductive system phenotype
  • abnormal reproductive system morphology
    • some mice exhibit unilateral genital agenesia   (MGI Ref ID J:13039)
  • limbs/digits/tail phenotype
  • abnormal digit morphology
    • digit abnormalities are usually bilateral and asymmetric   (MGI Ref ID J:13039)
    • the right foot is often more severely affected than the left   (MGI Ref ID J:13039)
    • oligodactyly
      • some mice have as few as 3 digits per foot   (MGI Ref ID J:13039)
    • polydactyly
      • some mice have up to seven digits per foot   (MGI Ref ID J:13039)
  • abnormal hindlimb morphology
    • the hindlimbs below the knee appear twisted   (MGI Ref ID J:13039)
    • absent tibia   (MGI Ref ID J:13039)
  • abnormal tarsal bone morphology
    • the tarsus displays fusion of adjacent elements and losses with all the preaxial elements missing   (MGI Ref ID J:13039)
  • brachypodia   (MGI Ref ID J:13039)
  • renal/urinary system phenotype
  • abnormal kidney morphology
    • some kidneys are horseshoe-shaped   (MGI Ref ID J:13039)
    • absent kidney
      • some mice display kidney agenesis   (MGI Ref ID J:13039)
    • enlarged kidney
      • mice that die prior to weaning exhibit distended kidney (unilateral or bilateral) and ureters   (MGI Ref ID J:13039)
    • hydronephrosis
      • unilateral or bilateral   (MGI Ref ID J:13039)
  • dilated ureter   (MGI Ref ID J:13039)
  • hydroureter   (MGI Ref ID J:13039)
  • behavior/neurological phenotype
  • impaired limb coordination
    • unlike wild-type mice, when mice fall they cannot control their rotation and do not land on their feet   (MGI Ref ID J:13039)
  • paresis
    • mice exhibit loss of hindlimb function that is unilateral (preferentially the right hindlimb) though occassionally bilateral   (MGI Ref ID J:13039)
    • however, mice can still walk and swim albeit slower than wild-type mice   (MGI Ref ID J:13039)
  • growth/size/body phenotype
  • decreased body size   (MGI Ref ID J:13039)
  • skeleton phenotype
  • abnormal presacral vertebrae morphology
    • reduction of presacral vertebrae   (MGI Ref ID J:13039)
  • abnormal tarsal bone morphology
    • the tarsus displays fusion of adjacent elements and losses with all the preaxial elements missing   (MGI Ref ID J:13039)
  • absent tibia   (MGI Ref ID J:13039)

Lx/Lx

        CBA.Cg-Lx
  • embryogenesis phenotype
  • abnormal umbilical artery morphology
    • at day E11.5, the right umbilical artery is highly abnormal and, with the left umbilical artery, forms a ring which is often too small to allow free passage of the developing kidneys as they migrate forward   (MGI Ref ID J:14981)
  • small hindlimb buds
    • posterior limb buds are narrower than in wild-type mice   (MGI Ref ID J:14981)
  • limbs/digits/tail phenotype
  • small hindlimb buds
    • posterior limb buds are narrower than in wild-type mice   (MGI Ref ID J:14981)
  • cardiovascular system phenotype
  • abnormal umbilical artery morphology
    • at day E11.5, the right umbilical artery is highly abnormal and, with the left umbilical artery, forms a ring which is often too small to allow free passage of the developing kidneys as they migrate forward   (MGI Ref ID J:14981)

Lx/Lx+

        involves: fancier's silver mouse
  • limbs/digits/tail phenotype
  • polydactyly
    • mice exhibit paraxial polydactyly in hindlimbs   (MGI Ref ID J:13039)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

KitW-v related

Cancer Research
Growth Factors/Receptors/Cytokines
Increased Tumor Incidence
      Gonadal Tumors
      Gonadal Tumors: ovarian
Oncogenes

Dermatology Research
Color and White Spotting Defects

Developmental Biology Research
Neural Crest Defects

Endocrine Deficiency Research
Bone/Bone Marrow Defects
Gonad Defects
Skin Defects

Immunology, Inflammation and Autoimmunity Research
Immunodeficiency
      Mast Cell Deficiency

Neurobiology Research
Hearing Defects
Receptor Defects

Reproductive Biology Research
Developmental Defects Affecting Gonads
      germ cell deficient
Fertility Defects
Gonadal Tumors
      ovarian

Research Tools
Immunology, Inflammation and Autoimmunity Research
      Mast Cell Deficiency

Sensorineural Research
Hearing Defects

Lx related

Developmental Biology Research
Internal/Organ Defects
      urogenital
Skeletal Defects
      Oligodactyly

Internal/Organ Research
Kidney Defects

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol KitW-v
Allele Name viable dominant spotting
Allele Type Spontaneous
Common Name(s) KitWv; W'; W2; Wv; Wv;
Strain of Originsilvered black strain
Gene Symbol and Name Kit, kit oncogene
Chromosome 5
Gene Common Name(s) Bs; C-Kit; CD117; Dominant white spotting; Fdc; Gsfsco1; Gsfsco5; Gsfsow3; PBT; SCFR; SCO1; SCO5; SOW3; Ssm; Steel Factor Receptor; Tr-kit; W; belly-spot; dominant spotting; gsf spotted coat 1; gsf spotted coat 5; phenotype like Sl or W 3; spotted sterile male;
Molecular Note A C to T point mutation at nucleotide 2007 results in a threonine to methionine substitution at amino acid 660. [MGI Ref ID J:24351]
 
Allele Symbol Lx
Allele Name luxate
Allele Type Spontaneous
Strain of Originfancier's silver mouse
Gene Symbol and Name Lx, luxate
Chromosome 5
Molecular Note The luxate mutation was found in descendants of a silver mouse obtained from a fancier.

Genotyping

Genotyping Information


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Additional References

Arguello F; Furlanetto RW; Baggs RB; Graves BT; Harwell SE; Cohen HJ; Frantz CN. 1992. Incidence and distribution of experimental metastases in mutant mice with defective organ microenvironments (genotypes Sl/Sld and W/Wv). Cancer Res 52(8):2304-9. [PubMed: 1559233]  [MGI Ref ID J:468]

Kitamura Y; Kasugai T; Ebi Y; Nomura S. 1991. Fibroblast-dependent differentiation/proliferation of mast cells. Skin Pharmacol 4 Suppl 1:2-7. [PubMed: 1764248]  [MGI Ref ID J:619]

Murphy ED. 1972. Hyperplastic and early neoplastic changes in the ovaries of mice after genic deletion of germ cells. J Natl Cancer Inst 48(5):1283-95. [PubMed: 4337905]  [MGI Ref ID J:5274]

Nocka K; Tan JC; Chiu E; Chu TY; Ray P; Traktman P; Besmer P. 1990. Molecular bases of dominant negative and loss of function mutations at the murine c-kit/white spotting locus: W37, Wv, W41 and W. EMBO J 9(6):1805-13. [PubMed: 1693331]  [MGI Ref ID J:10528]

Yada Y; Makino S; Chigusa-Ishiwa S; Shiroishi T. 2002. The mouse polydactylous mutation, luxate (lx), causes anterior shift of the anteroposterior border in the developing hindlimb bud. Int J Dev Biol 46(7):975-82. [PubMed: 12455637]  [MGI Ref ID J:81331]

KitW-v related

Akahoshi M; Song CH; Piliponsky AM; Metz M; Guzzetta A; Abrink M; Schlenner SM; Feyerabend TB; Rodewald HR; Pejler G; Tsai M; Galli SJ. 2011. Mast cell chymase reduces the toxicity of Gila monster venom, scorpion venom, and vasoactive intestinal polypeptide in mice. J Clin Invest 121(10):4180-91. [PubMed: 21926462]  [MGI Ref ID J:178494]

Allix S; Reyes-Gomez E; Aubin-Houzelstein G; Noel D; Tiret L; Panthier JJ; Bernex F. 2008. Uterine contractions depend on KIT-positive interstitial cells in the mouse: genetic and pharmacological evidence. Biol Reprod 79(3):510-7. [PubMed: 18480468]  [MGI Ref ID J:140900]

Anderson AL; Sporici R; Lambris J; Larosa D; Levinson AI. 2006. Pathogenesis of B-cell superantigen-induced immune complex-mediated inflammation. Infect Immun 74(2):1196-203. [PubMed: 16428769]  [MGI Ref ID J:104987]

Andoh T; Sakai K; Urashima M; Kitazawa K; Honma A; Kuraishi Y. 2012. Involvement of leukotriene B4 in itching in a mouse model of ocular allergy. Exp Eye Res 98:97-103. [PubMed: 22504036]  [MGI Ref ID J:196831]

Antonchuk J; Hyland CD; Hilton DJ; Alexander WS. 2004. Synergistic effects on erythropoiesis, thrombopoiesis, and stem cell competitiveness in mice deficient in thrombopoietin and steel factor receptors. Blood 104(5):1306-13. [PubMed: 15138166]  [MGI Ref ID J:92703]

Aoki H; Hara A; Motohashi T; Kunisada T. 2011. Protective effect of Kit signaling for melanocyte stem cells against radiation-induced genotoxic stress. J Invest Dermatol 131(9):1906-15. [PubMed: 21633369]  [MGI Ref ID J:182201]

Aoki H; Yamada Y; Hara A; Kunisada T. 2009. Two distinct types of mouse melanocyte: differential signaling requirement for the maintenance of non-cutaneous and dermal versus epidermal melanocytes. Development 136(15):2511-21. [PubMed: 19553284]  [MGI Ref ID J:152856]

Aoki R; Kawamura T; Goshima F; Ogawa Y; Nakae S; Nakao A; Moriishi K; Nishiyama Y; Shimada S. 2013. Mast Cells Play a Key Role in Host Defense against Herpes Simplex Virus Infection through TNF-alpha and IL-6 Production. J Invest Dermatol 133(9):2170-9. [PubMed: 23528820]  [MGI Ref ID J:200049]

April CS; Barsh GS. 2007. Distinct Pigmentary and Melanocortin 1 Receptor-Dependent Components of Cutaneous Defense against Ultraviolet Radiation. PLoS Genet 3(1):e9. [PubMed: 17222061]  [MGI Ref ID J:118235]

Arinobu Y; Iwasaki H; Gurish MF; Mizuno S; Shigematsu H; Ozawa H; Tenen DG; Austen KF; Akashi K. 2005. Developmental checkpoints of the basophil/mast cell lineages in adult murine hematopoiesis. Proc Natl Acad Sci U S A 102(50):18105-10. [PubMed: 16330751]  [MGI Ref ID J:104357]

Arnold K; Sarkar A; Yram MA; Polo JM; Bronson R; Sengupta S; Seandel M; Geijsen N; Hochedlinger K. 2011. Sox2(+) adult stem and progenitor cells are important for tissue regeneration and survival of mice. Cell Stem Cell 9(4):317-29. [PubMed: 21982232]  [MGI Ref ID J:177655]

Ayach BB; Yoshimitsu M; Dawood F; Sun M; Arab S; Chen M; Higuchi K; Siatskas C; Lee P; Lim H; Zhang J; Cukerman E; Stanford WL; Medin JA; Liu PP. 2006. Stem cell factor receptor induces progenitor and natural killer cell-mediated cardiac survival and repair after myocardial infarction. Proc Natl Acad Sci U S A 103(7):2304-9. [PubMed: 16467148]  [MGI Ref ID J:106065]

Azuma T; Dojyo M; Ito S; Yamazaki Y; Miyaji H; Ito Y; Suto H; Kuriyama M; Kato T; Kohli Y. 1999. Bile reflux due to disturbed gastric movement is a cause of spontaneous gastric ulcer in W/Wv mice. Dig Dis Sci 44(6):1177-83. [PubMed: 10389693]  [MGI Ref ID J:57206]

Balvers M; Spiess AN; Domagalski R; Hunt N; Kilic E; Mukhopadhyay AK; Hanks E; Charlton HM; Ivell R. 1998. Relaxin-like factor expression as a marker of differentiation in the mouse testis and ovary. Endocrinology 139(6):2960-70. [PubMed: 9607807]  [MGI Ref ID J:114270]

Baumann U; Chouchakova N; Gewecke B; Kohl J; Carroll MC; Schmidt RE; Gessner JE. 2001. Distinct tissue site-specific requirements of mast cells and complement components C3/C5a receptor in IgG immune complex-induced injury of skin and lung. J Immunol 167(2):1022-7. [PubMed: 11441111]  [MGI Ref ID J:120524]

Beamer WG; Tennent BJ. 1986. Gonadotropin uptake in genetic and irradiation models of ovarian tumorigenesis. Biol Reprod 34(4):761-70. [PubMed: 3085740]  [MGI Ref ID J:48594]

Beckett EA; McGeough CA; Sanders KM; Ward SM. 2003. Pacing of interstitial cells of Cajal in the murine gastric antrum: neurally mediated and direct stimulation. J Physiol 553(Pt 2):545-59. [PubMed: 14500772]  [MGI Ref ID J:105541]

Beckett EA; Ro S; Bayguinov Y; Sanders KM; Ward SM. 2007. Kit signaling is essential for development and maintenance of interstitial cells of Cajal and electrical rhythmicity in the embryonic gastrointestinal tract. Dev Dyn 236(1):60-72. [PubMed: 16937373]  [MGI Ref ID J:116633]

Bennett JL; Blanchet MR; Zhao L; Zbytnuik L; Antignano F; Gold M; Kubes P; McNagny KM. 2009. Bone marrow-derived mast cells accumulate in the central nervous system during inflammation but are dispensable for experimental autoimmune encephalomyelitis pathogenesis. J Immunol 182(9):5507-14. [PubMed: 19380799]  [MGI Ref ID J:147712]

Bernstein SE. 1969. Hereditary disorders of the rodent erythron. In: Genetics in Laboratory Animal Medicine. Natl Acad Sci Publ, Washington, DC.  [MGI Ref ID J:30699]

Bhetwal BP; Sanders KM; An C; Trappanese DM; Moreland RS; Perrino BA. 2013. Ca2+ sensitization pathways accessed by cholinergic neurotransmission in the murine gastric fundus. J Physiol 591(Pt 12):2971-86. [PubMed: 23613531]  [MGI Ref ID J:210571]

Biedermann T; Kneilling M; Mailhammer R; Maier K; Sander CA; Kollias G; Kunkel SL; Hultner L; Rocken M. 2000. Mast cells control neutrophil recruitment during T cell-mediated delayed-type hypersensitivity reactions through tumor necrosis factor and macrophage inflammatory protein 2 J Exp Med 192(10):1441-52. [PubMed: 11085746]  [MGI Ref ID J:65843]

Binstadt BA; Patel PR; Alencar H; Nigrovic PA; Lee DM; Mahmood U; Weissleder R; Mathis D; Benoist C. 2006. Particularities of the vasculature can promote the organ specificity of autoimmune attack. Nat Immunol 7(3):284-92. [PubMed: 16444258]  [MGI Ref ID J:112604]

Blanchet MR; Gold M; Maltby S; Bennett J; Petri B; Kubes P; Lee DM; McNagny KM. 2010. Loss of CD34 leads to exacerbated autoimmune arthritis through increased vascular permeability. J Immunol 184(3):1292-9. [PubMed: 20038636]  [MGI Ref ID J:159534]

Boddy G; Daniel EE. 2005. Role of l-Ca(2+) channels in intestinal pacing in wild-type and W/W(V) mice. Am J Physiol Gastrointest Liver Physiol 288(3):G439-46. [PubMed: 15486346]  [MGI Ref ID J:97237]

Bosch-Marce M; Okuyama H; Wesley JB; Sarkar K; Kimura H; Liu YV; Zhang H; Strazza M; Rey S; Savino L; Zhou YF; McDonald KR; Na Y; Vandiver S; Rabi A; Shaked Y; Kerbel R; Lavallee T; Semenza GL. 2007. Effects of aging and hypoxia-inducible factor-1 activity on angiogenic cell mobilization and recovery of perfusion after limb ischemia. Circ Res 101(12):1310-8. [PubMed: 17932327]  [MGI Ref ID J:142789]

Bradley J; Baltus A; Skaletsky H; Royce-Tolland M; Dewar K; Page DC. 2004. An X-to-autosome retrogene is required for spermatogenesis in mice. Nat Genet 36(8):872-6. [PubMed: 15258580]  [MGI Ref ID J:91708]

Brito FC; Kos L. 2008. Timeline and distribution of melanocyte precursors in the mouse heart. Pigment Cell Melanoma Res 21(4):464-70. [PubMed: 18444965]  [MGI Ref ID J:138178]

Burke JM; Ganley-Leal LM; Khatri A; Wetzler LM. 2007. Neisseria meningitidis PorB, a TLR2 ligand, induces an antigen-specific eosinophil recall response: potential adjuvant for helminth vaccines? J Immunol 179(5):3222-30. [PubMed: 17709538]  [MGI Ref ID J:151825]

Cable J; Barkway C; Steel KP. 1992. Characteristics of stria vascularis melanocytes of viable dominant spotting (Wv/Wv) mouse mutants. Hear Res 64(1):6-20. [PubMed: 1490901]  [MGI Ref ID J:4062]

Cable J; Jackson IJ; Steel KP. 1995. Mutations at the W locus affect survival of neural crest-derived melanocytes in the mouse. Mech Dev 50(2-3):139-50. [PubMed: 7619726]  [MGI Ref ID J:24351]

Cara DC; Ebbert KV; McCafferty DM. 2004. Mast cell-independent mechanisms of immediate hypersensitivity: a role for platelets. J Immunol 172(8):4964-71. [PubMed: 15067077]  [MGI Ref ID J:89115]

Cattanach BM; Raspberry C; Beechey CV. 1995. XY sex reversal associated with autosomal deletions Mouse Genome 93:426.  [MGI Ref ID J:133266]

Chakraborty P; William Buaas F; Sharma M; Smith BE; Greenlee AR; Eacker SM; Braun RE. 2014. Androgen-dependent sertoli cell tight junction remodeling is mediated by multiple tight junction components. Mol Endocrinol 28(7):1055-72. [PubMed: 24825397]  [MGI Ref ID J:210656]

Chappaz S; Gartner C; Rodewald HR; Finke D. 2010. Kit ligand and Il7 differentially regulate Peyer's patch and lymph node development. J Immunol 185(6):3514-9. [PubMed: 20709954]  [MGI Ref ID J:163826]

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Vincent L; Vang D; Nguyen J; Gupta M; Luk K; Ericson ME; Simone DA; Gupta K. 2013. Mast cell activation contributes to sickle cell pathobiology and pain in mice. Blood 122(11):1853-62. [PubMed: 23775718]  [MGI Ref ID J:202290]

Wang CH; Anderson N; Li SH; Szmitko PE; Cherng WJ; Fedak PW; Fazel S; Li RK; Yau TM; Weisel RD; Stanford WL; Verma S. 2006. Stem cell factor deficiency is vasculoprotective: unraveling a new therapeutic potential of imatinib mesylate. Circ Res 99(6):617-25. [PubMed: 16931795]  [MGI Ref ID J:125065]

Wang Z; Lai Y; Bernard JJ; Macleod DT; Cogen AL; Moss B; Di Nardo A. 2012. Skin mast cells protect mice against vaccinia virus by triggering mast cell receptor S1PR2 and releasing antimicrobial peptides. J Immunol 188(1):345-57. [PubMed: 22140255]  [MGI Ref ID J:180895]

Waskow C; Bartels S; Schlenner SM; Costa C; Rodewald HR. 2007. Kit is essential for PMA-inflammation-induced mast-cell accumulation in the skin. Blood 109(12):5363-70. [PubMed: 17327401]  [MGI Ref ID J:145426]

Wedemeyer J; Galli SJ. 2005. Decreased susceptibility of mast cell-deficient Kit(W)/Kit(W-v) mice to the development of 1, 2-dimethylhydrazine-induced intestinal tumors. Lab Invest 85(3):388-96. [PubMed: 15696191]  [MGI Ref ID J:96368]

Wei CC; Hase N; Inoue Y; Bradley EW; Yahiro E; Li M; Naqvi N; Powell PC; Shi K; Takahashi Y; Saku K; Urata H; Dell'italia LJ; Husain A. 2010. Mast cell chymase limits the cardiac efficacy of Ang I-converting enzyme inhibitor therapy in rodents. J Clin Invest 120(4):1229-39. [PubMed: 20335663]  [MGI Ref ID J:159675]

Wei OL; Hilliard A; Kalman D; Sherman M. 2005. Mast cells limit systemic bacterial dissemination but not colitis in response to Citrobacter rodentium. Infect Immun 73(4):1978-85. [PubMed: 15784538]  [MGI Ref ID J:97208]

Weller K; Foitzik K; Paus R; Syska W; Maurer M. 2006. Mast cells are required for normal healing of skin wounds in mice. FASEB J 20(13):2366-8. [PubMed: 16966487]  [MGI Ref ID J:129739]

Wershil BK; Castagliuolo I; Pothoulakis C. 1998. Direct evidence of mast cell involvement in Clostridium difficile toxin A-induced enteritis in mice. Gastroenterology 114(5):956-64. [PubMed: 9558284]  [MGI Ref ID J:107762]

Wershil BK; Theodos CM; Galli SJ; Titus RG. 1994. Mast cells augment lesion size and persistence during experimental Leishmania major infection in the mouse. J Immunol 152(9):4563-71. [PubMed: 8157970]  [MGI Ref ID J:17706]

White RA; Sokolovsky IV; Britt MI; Nsumu NN; Logsdon DP; McNulty SG; Wilmes LA; Brewer BP; Wirtz E; Joyce HR; Fegley B; Smith A; Heruth DP. 2009. Hematologic characterization and chromosomal localization of the novel dominantly inherited mouse hemolytic anemia, neonatal anemia (Nan). Blood Cells Mol Dis 43(2):141-8. [PubMed: 19409822]  [MGI Ref ID J:162530]

Williams CM; Galli SJ. 2000. Mast cells can amplify airway reactivity and features of chronic inflammation in an asthma model in mice. J Exp Med 192(3):455-62. [PubMed: 10934234]  [MGI Ref ID J:63872]

Won KJ; Sanders KM; Ward SM. 2005. Interstitial cells of Cajal mediate mechanosensitive responses in the stomach. Proc Natl Acad Sci U S A 102(41):14913-8. [PubMed: 16204383]  [MGI Ref ID J:102473]

Wouters M; De Laet A; Donck LV; Delpire E; van Bogaert PP; Timmermans JP; de Kerchove d'Exaerde A; Smans K; Vanderwinden JM. 2006. Subtractive hybridization unravels a role for the ion cotransporter NKCC1 in the murine intestinal pacemaker. Am J Physiol Gastrointest Liver Physiol 290(6):G1219-27. [PubMed: 16123204]  [MGI Ref ID J:111089]

Wulff BC; Parent AE; Meleski MA; DiPietro LA; Schrementi ME; Wilgus TA. 2012. Mast cells contribute to scar formation during fetal wound healing. J Invest Dermatol 132(2):458-65. [PubMed: 21993557]  [MGI Ref ID J:183187]

Yamaguchi N; Sugita R; Miki A; Takemura N; Kawabata J; Watanabe J; Sonoyama K. 2006. Gastrointestinal Candida colonisation promotes sensitisation against food antigens by affecting the mucosal barrier in mice. Gut 55(7):954-60. [PubMed: 16423887]  [MGI Ref ID J:135817]

Yang WL; Cai KQ; Smedberg JL; Smith ER; Klein-Szanto A; Hamilton TC; Xu XX. 2007. A reduction of cyclooxygenase 2 gene dosage counters the ovarian morphological aging and tumor phenotype in Wv mice. Am J Pathol 170(4):1325-36. [PubMed: 17392171]  [MGI Ref ID J:120134]

Ye L; Zhang EY; Xiong Q; Astle CM; Zhang P; Li Q; From AH; Harrison DE; Zhang JJ. 2012. Aging Kit mutant mice develop cardiomyopathy. PLoS One 7(3):e33407. [PubMed: 22428044]  [MGI Ref ID J:187053]

Yi C; Woo JM; Han C; Oh JS; Park I; Lee B; Jin S; Choi H; Kwon JT; Cho BN; Kim do H; Cho C. 2010. Expression analysis of the Adam21 gene in mouse testis. Gene Expr Patterns 10(2-3):152-8. [PubMed: 20117247]  [MGI Ref ID J:158508]

Yokozeki H; Wu MH; Sumi K; Igawa K; Miyazaki Y; Katayama I; Takeda K; Akira S; Nishioka K. 2003. Th2 cytokines, IgE and mast cells play a crucial role in the induction of para-phenylenediamine-induced contact hypersensitivity in mice. Clin Exp Immunol 132(3):385-92. [PubMed: 12780683]  [MGI Ref ID J:83737]

Yomogida K; Ohtani H; Harigae H; Ito E; Nishimune Y; Engel JD; Yamamoto M. 1994. Developmental stage- and spermatogenic cycle-specific expression of transcription factor GATA-1 in mouse Sertoli cells. Development 120(7):1759-66. [PubMed: 7924983]  [MGI Ref ID J:19188]

Yoshida S; Sukeno M; Nakagawa T; Ohbo K; Nagamatsu G; Suda T; Nabeshima Y. 2006. The first round of mouse spermatogenesis is a distinctive program that lacks the self-renewing spermatogonia stage. Development 133(8):1495-505. [PubMed: 16540512]  [MGI Ref ID J:107419]

Younan G; Suber F; Xing W; Shi T; Kunori Y; Abrink M; Pejler G; Schlenner SM; Rodewald HR; Moore FD Jr; Stevens RL; Adachi R; Austen KF; Gurish MF. 2010. The inflammatory response after an epidermal burn depends on the activities of mouse mast cell proteases 4 and 5. J Immunol 185(12):7681-90. [PubMed: 21076070]  [MGI Ref ID J:167465]

Yu M; Tsai M; Tam SY; Jones C; Zehnder J; Galli SJ. 2006. Mast cells can promote the development of multiple features of chronic asthma in mice. J Clin Invest 116(6):1633-41. [PubMed: 16710480]  [MGI Ref ID J:110366]

Zhao M; Rohozinski J; Sharma M; Ju J; Braun RE; Bishop CE; Meistrich ML. 2007. Utp14b: a unique retrogene within a gene that has acquired multiple promoters and a specific function in spermatogenesis. Dev Biol 304(2):848-59. [PubMed: 17291484]  [MGI Ref ID J:122508]

Zhou JS; Xing W; Friend DS; Austen KF; Katz HR. 2007. Mast cell deficiency in Kit(W-sh) mice does not impair antibody-mediated arthritis. J Exp Med 204(12):2797-802. [PubMed: 17998392]  [MGI Ref ID J:128512]

de Laval B; Pawlikowska P; Petit-Cocault L; Bilhou-Nabera C; Aubin-Houzelstein G; Souyri M; Pouzoulet F; Gaudry M; Porteu F. 2013. Thrombopoietin-increased DNA-PK-dependent DNA repair limits hematopoietic stem and progenitor cell mutagenesis in response to DNA damage. Cell Stem Cell 12(1):37-48. [PubMed: 23246483]  [MGI Ref ID J:194947]

de Lorijn F; de Jonge WJ; Wedel T; Vanderwinden JM; Benninga MA; Boeckxstaens GE. 2005. Interstitial cells of Cajal are involved in the afferent limb of the rectoanal inhibitory reflex. Gut 54(8):1107-13. [PubMed: 16009682]  [MGI Ref ID J:194727]

oRdog T; Baldo M; Danko R; Sanders KM. 2002. Plasticity of electrical pacemaking by interstitial cells of Cajal and gastric dysrhythmias in W/W mutant mice. Gastroenterology 123(6):2028-40. [PubMed: 12454859]  [MGI Ref ID J:80620]

van Buul PP; Tuinenburg-Bol Raap A; Goudzwaard HJ; Seelen CM; Beechey CV; Natarajan AT; Searle AG. 1991. Cytogenetic characterization of radiosensitive mouse mutants. Mutat Res 251(2):171-9. [PubMed: 1720867]  [MGI Ref ID J:4646]

Lx related

Carter TC. 1951. The genetics of luxate mice. I. Morphological abnormalities of heterozygotes and homozygotes. J Genet 50:277-299.  [MGI Ref ID J:13039]

Carter TC. 1953. The genetics of luxate mice. III. Horseshoe kidney, hydronephrosis and lumbar reduction. J Genet 51(3):443-457.  [MGI Ref ID J:13044]

Carter TC. 1954. The genetics of luxate mice. IV. Embryology J Genet 52:1-35.  [MGI Ref ID J:14981]

Dagg CP. 1967. Combined action of fluorouracil and two mutant genes on limb development in the mouse. J Exp Zool 164(3):479-89. [PubMed: 6068186]  [MGI Ref ID J:5039]

Long SY; Johnson EM. 1968. Enzyme ontogeny in normal and hemimelic limbs of mice. J Embryol Exp Morphol 20(3):415-30. [PubMed: 4302544]  [MGI Ref ID J:5097]

Masuya H; Sagai T; Moriwaki K; Shiroishi T. 1997. Multigenic control of the localization of the zone of polarizing activity in limb morphogenesis in the mouse. Dev Biol 182(1):42-51. [PubMed: 9073443]  [MGI Ref ID J:38196]

Searle AG. 1964. The genetics and morphology of two 'luxoid' mutants in the house mouse Genet Res 5:171-197.  [MGI Ref ID J:112]

Yada Y; Makino S; Chigusa-Ishiwa S; Shiroishi T. 2002. The mouse polydactylous mutation, luxate (lx), causes anterior shift of the anteroposterior border in the developing hindlimb bud. Int J Dev Biol 46(7):975-82. [PubMed: 12455637]  [MGI Ref ID J:81331]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $3300.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $4290.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Control Information

  Control
   Untyped from the colony
   Wild-type from the colony
   000664 C57BL/6J
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

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Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.


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The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


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