JAX Mice Database - 000199 AEJ/GnLeJ

Strain Name:	AEJ/GnLeJ
Stock Number:	000199
Availability:	Repository- Live

Description
Phenotype
Genes & alleles
Genotyping
Health & husbandry
References
Purchasing information
Terms of Use

Description

Strain Information

Type Radiation Induced Mutation;
Additional information on Genetically Engineered and Mutant Mice.

Type Inbred Strain;
Additional information on Inbred Strains.

Visit our online Nomenclature tutorial.

Species laboratory mouse

Generation [F82+p]+11 (15-DEC-06)

Appearance
dark black
Related Genotype: a^e/a^e

light-bellied agouti
Related Genotype: A^w-J/a^e
Important Note
This strain is segregating for recessive a^e and dominant A^w-J.

Control Information


		For A^w-J: a^e/a^e from the colony For a^e: A^w-J/a^e from the colony

Considerations for Choosing Controls

Related Strains

Strains carrying A^w-J allele

000202 AEJ/Gn-bd/J

000593 B6 x B6CBCa A^w-J/A-Grid2^Lc T(2;6)7Ca Mitf^Mi-wh/J

000502 B6 x B6CBCa A^w-J/A-Myo5a^flr Gnb5^flr/J

000599 B6 x B6CBCa A^w-J/A-T(5;13)264Ca Kit^W-v/J

002016 B6(Cg)-A^w-J Eda^Ta-6J Chr Y^B6-Sxr/EiJ

000552 B6-A^w-J-Eda^Ta-6J.Cg-Sxr

001730 B6-A^w-J-Eda^Ta-6J.Cg-Sxr^b Hya^-/J

000841 B6-A^w-J.CBy-Eda^Ta-By/J

001809 B6-A^w-J.Cg-Eda^Ta-6J +/+ Ar^Tfm/J

000600 B6-Gpi1^b x B6CBCa A^w-J/A-T(7;15)9H Gpi1^a/J

100409 B6129PF1/J-A^w-J/A^w

004200 B6;CBACa A^w-J/A-Npr2^cn-2J/GrsrJ

000505 B6C3 A^w-J/A-Muted^mu/J

000314 B6CBACa A^w-J/A-Eda^Ta/J-XO

000501 B6CBACa A^w-J/A-Aifm1^Hq/J

001046 B6CBACa A^w-J/A-Grid2^Lc/J

000500 B6CBACa A^w-J/A-Gs/J

002703 B6CBACa A^w-J/A-Hydin^hy3/J

000247 B6CBACa A^w-J/A-Kcnj6^wv/J

000287 B6CBACa A^w-J/A-Plp1^jp Eda^Ta/J

000515 B6CBACa A^w-J/A-Sfn^Er/J

000242 B6CBACa A^w-J/A-spc/J

000288 B6CBACa A^w-J/A-we a Mafb^kr/J

001201 B6CBACaF1/J-A^w-J/A

001752 B6CBCa A^w-J/A-T(7;15)9H/J

000200 C3FeB6 A/A^w-J-Ank^ank/J

000638 C3FeB6 A/A^w-J-Spnb4^qv-J/J

001203 C3FeB6F1/J A/A^w-J

000338 C57BL/6J A^w-J-Eda^Ta-6J/J

000569 C57BL/6J-A^w-J-Eda^Ta +/+ Ar^Tfm/J

000051 C57BL/6J-A^w-J/J

View Strains carrying A^w-J (31 strains)

Strains carrying a^e allele

000251 AEJ.Cg-a^e +/a Gdf5^bp-H/J

000202 AEJ/Gn-bd/J

View Strains carrying a^e (2 strains)

Strains carrying other alleles of a

003301 (C57BL/6J x C3H-Eya1^bor)F1/J

000433 B10.C-H3^c H13^? A/(28NX)SnJ

000427 B10.CE-H13^b A^w/(30NX)SnJ

000423 B10.KR-H13^? A/SnJ

000420 B10.LP-H13^b A^w/Sn

000477 B10.PA-Pldn^pa H3^e a^t/SnJ

000419 B10.UW-H3^b we Pax1^un a^t/SnJ

003879 B10;TFLe-a/a T tf/+ tf/J

001538 B6 x B6C3Sn a/A-T(1;9)27H/J

000916 B6 x B6C3Sn a/A-T(5;12)31H/J

000602 B6 x B6C3Sn a/A-T(8;16)17H/J

002083 B6 x B6EiC3 a/A-T(7;16)235Dn/J

000507 B6 x B6EiC3 a/A-Otc^spf/J

003759 B6 x B6EiC3Sn a/A-T(10;16)232Dn/J

002071 B6 x B6EiC3Sn a/A-T(11;17)202Dn/J

002113 B6 x B6EiC3Sn a/A-T(11A2;16B3)238Dn/J

002068 B6 x B6EiC3Sn a/A-T(11B1;16B5)233Dn/J

002069 B6 x B6EiC3Sn a/A-T(14E4or5;16B5)225Dn/J

001926 B6 x B6EiC3Sn a/A-T(15;16)198Dn/J

001832 B6 x B6EiC3Sn a/A-T(15E;16B1)60Dn/J

003758 B6 x B6EiC3Sn a/A-T(16C3-4;17A2)65Dn/J

001833 B6 x B6EiC3Sn a/A-T(1C2;16C3)45Dn/J

001903 B6 x B6EiC3Sn a/A-T(6F;18C)57Dn/J

001535 B6 x B6EiC3Sn a/A-T(8A4;12D1)69Dn/J

001831 B6 x B6EiC3Sn a/A-T(8C3;16B5)164Dn/J

000618 B6 x FSB/GnEi a/a Ctsl^fs/J

000577 B6 x STOCK a Oca2^p Hps5^ru2 Ednrb^s/J

000601 B6 x STOCK a/a T(7;18)50H/J

000592 B6 x STOCK T(2;4)13H a/J

000769 B6.C/(HZ18)By-a^t-44J/J

000001 B6.C3 A/a Mgrn1^md/J

000203 B6.C3-A^iy/a/J

000017 B6.C3-A^vy/J

001572 B6.C3-a^m-J/J

000628 B6.CE-A Amy1^b Amy2a5^b/J

000021 B6.Cg-A^y/J

000231 B6;C3Fe a/a-Csf1^op/J

004200 B6;CBACa A^w-J/A-Npr2^cn-2J/GrsrJ

000785 B6;D2-a Es1^e/EiJ

000604 B6C3 a/A-T(10;13)199H +/+ Lyst^bg-J/J or Lyst^bg-2J/J

002807 B6C3Fe a/a-Meox2^fla/J

000224 B6C3Fe a/a-Scyl1^mdf/J

001037 B6C3Fe a/a-Agtpbp1^pcd/J

000221 B6C3Fe a/a-Alx4^lst-J/J

002062 B6C3Fe a/a-Atp7a^Mo-8J/J

001756 B6C3Fe a/a-Cacng2^stg/J

001815 B6C3Fe a/a-Col1a2^oim/J

000209 B6C3Fe a/a-Dh/J

000211 B6C3Fe a/a-Dst^dt-J/J

000210 B6C3Fe a/a-Edar^dl-J/J

000207 B6C3Fe a/a-Edaradd^cr/J

000182 B6C3Fe a/a-Eef1a2^wst/J

001278 B6C3Fe a/a-Glra1^spd/J

000241 B6C3Fe a/a-Glrb^spa/J

002875 B6C3Fe a/a-Hoxd13^spdh/J

000304 B6C3Fe a/a-Krt71^Ca Scn8a^med-J/J

000226 B6C3Fe a/a-Large^myd/J

000636 B6C3Fe a/a-Lmx1a^dr-J/J

001280 B6C3Fe a/a-Lse/J

001573 B6C3Fe a/a-Mitf^Mi/J

001035 B6C3Fe a/a-Napa^hyh/J

000181 B6C3Fe a/a-Otog^twt/J

000278 B6C3Fe a/a-Papss2^bm Hps1^ep Hps6^ru/J

000205 B6C3Fe a/a-Papss2^bm/J

002078 B6C3Fe a/a-Pcdh15^av-2J/J

000246 B6C3Fe a/a-Pitpna^vb/J

001430 B6C3Fe a/a-Ptch1^mes/J

000506 B6C3Fe a/a-Qk^qk/J

000235 B6C3Fe a/a-Reln^rl/J

000237 B6C3Fe a/a-Rora^sg/J

000290 B6C3Fe a/a-Sox10^Dom/J

000230 B6C3Fe a/a-Tcirg1^oc/J

003612 B6C3Fe a/a-Trak1^hyrt/J

001512 B6C3Fe a/a-Ttn^mdm/J

001607 B6C3Fe a/a-Unc5c^rcm/J

000005 B6C3Fe a/a-Wc/J

000243 B6C3Fe a/a-Wnt1^sw/J

000248 B6C3Fe a/a-Xpl/J

001750 B6C3Fe a/a-Xs^J/J

000624 B6C3Fe a/a-anx/J

008044 B6C3Fe a/a-bpck/J

003020 B6C3Fe a/a-dep/J

002018 B6C3Fe a/a-din/J

002339 B6C3Fe a/a-nma/J

000240 B6C3Fe a/a-soc/J

000063 B6C3Fe a/a-sy/J

001055 B6C3Fe a/a-tip/J

000245 B6C3Fe a/a-tn/J

000065 B6C3Fe a/a-we Pax1^un a^t/J

000296 B6C3Fe-a/a Hoxa13^Hd Mcoln3^Va-J/J

000019 B6C3Fe-a/a-Itpr1^opt/J

001022 B6C3FeF1/J a/a

001752 B6CBCa A^w-J/A-T(7;15)9H/J

006450 B6EiC3 a/A-Vss/GrsrJ

000971 B6EiC3 a/A-Och/J

000551 B6EiC3 a/A-Tbx15^de-H/J

000557 B6EiC3-+ a/Lnp^Ul A/J

000504 B6EiC3Sn a/A-Cacnb4^lh/J

000553 B6EiC3Sn a/A-Egfr^wa2 Wnt3a^vt/J

000503 B6EiC3Sn a/A-Gy/J

001811 B6EiC3Sn a/A-Otc^spf-ash/J

002343 B6EiC3Sn a/A-Otc^spf/J

000391 B6EiC3Sn a/A-Pax6^Sey-Dey/J

001924 B6EiC3Sn a/A-Ts(17¹⁶)65Dn

001923 B6EiC3Sn a/A-Ts(4¹⁷)2Lws Tim/J

001875 B6EiC3SnF1/J

000200 C3FeB6 A/A^w-J-Ank^ank/J

000638 C3FeB6 A/A^w-J-Spnb4^qv-J/J

000225 C3FeLe.B6 a/a-Ptpn6^me/J

008425 C3FeLe.B6-a Trl/J

000198 C3FeLe.B6-a/J

000291 C3FeLe.Cg-a/a Hm Kitl^Sl Krt71^Ca-J/J

001272 C3H/HeSnJ-A^hvy/J

000099 C3HeB/FeJ-A^vy/J

001886 C3HeB/FeJLe a/a-gnd/J

000584 C57BL/6J-+ T(1;2)5Ca/a +/J

000258 C57BL/6J-Aⁱ/a/J

000774 C57BL/6J-A^sy/a/J

000055 C57BL/6J-a^t-33J/J

000070 C57BL/6J-a^td/J

000284 CWD/LeJ

000670 DBA/1J

000671 DBA/2J

001057 HPT/LeJ

000260 JGBF/LeJ

002468 KK.Cg-A^y/J

000262 LS/LeJ

000283 LT.CAST-A/J

000265 MY/HuLeJ

000308 SSL/LeJ

001759 STOCK A Tyr^c Sha/J

001427 STOCK A^w us/J

000994 STOCK a Myo5a^d Mreg^dsu/J

000064 STOCK a Tyrp1^b Si^si/J

002238 STOCK a Tyrp1^b shmy/J

001433 STOCK a skt/J

000579 STOCK a tp/J

000319 STOCK a us/J

002648 STOCK a/a Cln6^nclf/J

000317 STOCK a/a Egfr^wa2/J

000302 STOCK a/a Mitf^Mi-wh +/+ Itpr1^opt/J

000286 STOCK a/a Myo5a^d fd/+ +/J

000206 STOCK a/a Tyr^c-h/J

001432 STOCK a/a Tyrp1^b sks/Tyrp1^b +/J

000281 STOCK a/a ma Flg^ft/ma Flg^ft/J

000312 STOCK stb + a/+ Fign^fi a/J

000596 STOCK T(2;11)30H/+ x AEJ-a Gdf5^bp-H/J or A/J-a Gdf5^bp-J/J

000970 STOCK T(2;16)28H A/T(2;16)28H a/J

000590 STOCK T(2;4)1Sn a/J

000594 STOCK T(2;8)26H a/T(2;8)26H a Tyrp1⁺/Tyrp1^b/J

000623 TR/DiEiJ

View Strains carrying other alleles of a (151 strains)

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms
assigned by genotype

The following phenotype information may relate to a genetic background differing from this JAX^® Mice strain.
a^e/a^e
(P x S)F1
pigmentation phenotype

abnormal coat/hair pigmentation (MGI Ref ID J:13070)

darkened coat color (MGI Ref ID J:13070)

black is more intense than homozygous non-agouti

no yellow hairs in the ears or around nipples and perineum as found in homozygous non-agouti mice

skin/coat/nails phenotype

abnormal coat/hair pigmentation (MGI Ref ID J:13070)

darkened coat color (MGI Ref ID J:13070)

black is more intense than homozygous non-agouti

no yellow hairs in the ears or around nipples and perineum as found in homozygous non-agouti mice

View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Dermatology Research
Color and White Spotting Defects

a^e related

Dermatology Research
Color and White Spotting Defects

Genes & Alleles

Gene & Allele Information


Allele Symbol		A^w-J
Allele Name		white bellied agouti Jackson
Allele Type		Spontaneous
Common Name(s)		A^WJ;
Strain of Origin		C57BL/6J
Gene Symbol and Name		a, nonagouti
Chromosome		2
Gene Common Name(s)		AGSW; AGTI; AGTIL; ASP; As; MGC126092; MGC126093; SHEP9; agouti; agouti signal protein; agouti suppressor;

Allele Symbol		a^e
Allele Name		extreme nonagouti
Allele Type		Radiation induced
Strain of Origin		(P x S)F1
Gene Symbol and Name		a, nonagouti
Chromosome		2
Gene Common Name(s)		AGSW; AGTI; AGTIL; ASP; As; MGC126092; MGC126093; SHEP9; agouti; agouti signal protein; agouti suppressor;
General Note		The a^e mutation was found among descendants of an irradiated mouse. a^e is recessive to all other alleles except a^l.

Genotyping

Genotyping Information

This strain will not have a genotyping protocol or one is not currently available.

Helpful Links

Genotyping resources and troubleshooting

References

Additional References

Bultman SJ; Michaud EJ; Woychik RP. 1992. Molecular characterization of the mouse agouti locus. Cell 71(7):1195-204. [PubMed: 1473152] [MGI Ref ID J:3523]

Hustad CM; Perry WL; Siracusa LD; Rasberry C; Cobb L; Cattanach BM; Kovatch R; Copeland NG; Jenkins NA. 1995. Molecular genetic characterization of six recessive viable alleles of the mouse agouti locus. Genetics 140(1):255-65. [PubMed: 7635290] [MGI Ref ID J:24934]

Miller MW; Duhl DM; Vrieling H; Cordes SP; Ollmann MM; Winkes BM; Barsh GS. 1993. Cloning of the mouse agouti gene predicts a secreted protein ubiquitously expressed in mice carrying the lethal yellow mutation. Genes Dev 7(3):454-67. [PubMed: 8449404] [MGI Ref ID J:4186]

Vrieling H; Duhl DM; Millar SE; Miller KA; Barsh GS. 1994. Differences in dorsal and ventral pigmentation result from regional expression of the mouse agouti gene. Proc Natl Acad Sci U S A 91(12):5667-71. [PubMed: 8202545] [MGI Ref ID J:18750]
A^w-J related

Aberg T; Wang XP; Kim JH; Yamashiro T; Bei M; Rice R; Ryoo HM; Thesleff I. 2004. Runx2 mediates FGF signaling from epithelium to mesenchyme during tooth morphogenesis. Dev Biol 270(1):76-93. [PubMed: 15136142] [MGI Ref ID J:92174]

Barsh GS; Epstein CJ. 1989. Physical and genetic characterization of a 75-kilobase deletion associated with al, a recessive lethal allele at the mouse agouti locus. Genetics 121(4):811-8. [PubMed: 2566558] [MGI Ref ID J:9799]

Baurle J; Vogten H; Grusser-Cornehls U. 1998. Course and targets of the calbindin D-28k subpopulation of primary vestibular afferents. J Comp Neurol 402(1):111-28. [PubMed: 9831049] [MGI Ref ID J:118430]

Boran T; Lesot H; Peterka M; Peterkova R. 2005. Increased apoptosis during morphogenesis of the lower cheek teeth in tabby/EDA mice. J Dent Res 84(3):228-33. [PubMed: 15723861] [MGI Ref ID J:112546]

Chinta SJ; Rane A; Yadava N; Andersen JK; Nicholls DG; Polster BM. 2009. Reactive oxygen species regulation by AIF- and complex I-depleted brain mitochondria. Free Radic Biol Med 46(7):939-47. [PubMed: 19280713] [MGI Ref ID J:145908]

Cui CY; Hashimoto T; Grivennikov SI; Piao Y; Nedospasov SA; Schlessinger D. 2006. Ectodysplasin regulates the lymphotoxin-beta pathway for hair differentiation. Proc Natl Acad Sci U S A 103(24):9142-7. [PubMed: 16738056] [MGI Ref ID J:111051]

Cui CY; Kunisada M; Esibizione D; Grivennikov SI; Piao Y; Nedospasov SA; Schlessinger D. 2007. Lymphotoxin-beta regulates periderm differentiation during embryonic skin development. Hum Mol Genet 16(21):2583-90. [PubMed: 17673451] [MGI Ref ID J:129949]

Dickie MM. 1969. Mutations at the agouti locus in the mouse. J Hered 60(1):20-5. [PubMed: 5798139] [MGI Ref ID J:30922]

Esibizione D; Cui CY; Schlessinger D. 2008. Candidate EDA targets revealed by expression profiling of primary keratinocytes from Tabby mutant mice. Gene 427(1-2):42-6. [PubMed: 18848976] [MGI Ref ID J:143603]

Granholm DE; Reese RN; Granholm NH. 1996. Agouti alleles alter cysteine and glutathione concentrations in hair follicles and serum of mice (A y/a, A wJ/A wJ, and a/a). J Invest Dermatol 106(3):559-63. [PubMed: 8648194] [MGI Ref ID J:32132]

Granholm DE; Reese RN; Granholm NH. 1995. Agouti alleles influence thiol concentrations in hair follicles and extrafollicular tissues of mice (Ay/a, AwJ/AwJ, a/a). Pigment Cell Res 8(6):302-6. [PubMed: 8789738] [MGI Ref ID J:31403]

Jones JM; Huang JD; Mermall V; Hamilton BA; Mooseker MS; Escayg A; Copeland NG; Jenkins NA; Meisler MH. 2000. The mouse neurological mutant flailer expresses a novel hybrid gene derived by exon shuffling between Gnb5 and Myo5a. Hum Mol Genet 9(5):821-8. [PubMed: 10749990] [MGI Ref ID J:61324]

Kappenman KE; Dvoracek MA; Harvison GA; Fuller BB; Granholm NH. 1992. Tyrosinase abundance and activity in murine hairbulb melanocytes of agouti mutants (C57BL/6J-a/a, Ay/a, and AwJ/AwJ). Pigment Cell Res Suppl 2:79-83. [PubMed: 1409442] [MGI Ref ID J:1295]

Katoh A; Yoshida T; Himeshima Y; Mishina M; Hirano T. 2005. Defective control and adaptation of reflex eye movements in mutant mice deficient in either the glutamate receptor delta2 subunit or Purkinje cells. Eur J Neurosci 21(5):1315-26. [PubMed: 15813941] [MGI Ref ID J:101081]

Knapp PE; Adjan VV; Hauser KF. 2009. Cell-specific loss of kappa-opioid receptors in oligodendrocytes of the dysmyelinating jimpy mouse. Neurosci Lett 451(2):114-8. [PubMed: 19110031] [MGI Ref ID J:146365]

Lee M; Kim A; Chua SC Jr; Obici S; Wardlaw SL. 2007. Transgenic MSH overexpression attenuates the metabolic effects of a high-fat diet. Am J Physiol Endocrinol Metab 293(1):E121-31. [PubMed: 17374695] [MGI Ref ID J:126508]

Lu W; Tsirka SE. 2002. Partial rescue of neural apoptosis in the Lurcher mutant mouse through elimination of tissue plasminogen activator. Development 129(8):2043-50. [PubMed: 11934869] [MGI Ref ID J:111363]

Mayer TC; Fishbane JL. 1972. Mesoderm-ectoderm interaction in the production of the agouti pigmentation pattern in mice. Genetics 71(2):297-303. [PubMed: 4558326] [MGI Ref ID J:5288]

Mitsumori K; Yasuhara K; Mori I; Hayashi S; Shimo T; Onodera H; Nomura T; Hayashi Y. 1998. Pulmonary fibrosis caused by N-methyl-N-nitrosourethane inhibits lung tumorigenesis by urethane in transgenic mice carrying the human prototype c-Ha-ras gene. Cancer Lett 129(2):181-90. [PubMed: 9719460] [MGI Ref ID J:52138]

Monroe DG; Wipf LP; Diggins MR; Matthees DP; Granholm NH. 1998. Agouti-related maturation and tissue distribution of alpha-Melanocyte Stimulating Hormone in wild-type (AwJ/AwJ) and mutant (Ay/a,a/a) mice. Pigment Cell Res 11(5):310-3. [PubMed: 9877102] [MGI Ref ID J:52183]

Mullen RJ. 1974. A<w-J> - white-bellied agouti-J Mouse News Lett 50:38. [MGI Ref ID J:64104]

Mustonen T; Ilmonen M; Pummila M; Kangas AT; Laurikkala J; Jaatinen R; Pispa J; Gaide O; Schneider P; Thesleff I; Mikkola ML. 2004. Ectodysplasin A1 promotes placodal cell fate during early morphogenesis of ectodermal appendages. Development 131(20):4907-19. [PubMed: 15371307] [MGI Ref ID J:128256]

O'donnell SM; Hansberger MW; Connolly JL; Chappell JD; Watson MJ; Pierce JM; Wetzel JD; Han W; Barton ES; Forrest JC; Valyi-Nagy T; Yull FE; Blackwell TS; Rottman JN; Sherry B; Dermody TS. 2005. Organ-specific roles for transcription factor NF-kappaB in reovirus-induced apoptosis and disease. J Clin Invest 115(9):2341-2350. [PubMed: 16100570] [MGI Ref ID J:100906]

Peng J; Wu Z; Wu Y; Hsu M; Stevenson FF; Boonplueang R; Roffler-Tarlov SK; Andersen JK. 2002. Inhibition of caspases protects cerebellar granule cells of the weaver mouse from apoptosis and improves behavioral phenotype. J Biol Chem 277(46):44285-91. [PubMed: 12221097] [MGI Ref ID J:119427]

Peng J; Xie L; Stevenson FF; Melov S; Di Monte DA; Andersen JK. 2006. Nigrostriatal dopaminergic neurodegeneration in the weaver mouse is mediated via neuroinflammation and alleviated by minocycline administration. J Neurosci 26(45):11644-51. [PubMed: 17093086] [MGI Ref ID J:114943]

Poole TW. 1975. Dermal-epidermal interactions and the action of alleles at the agouti locus in the mouse. Dev Biol 42(2):203-10. [PubMed: 1090472] [MGI Ref ID J:5519]

Probst FJ; Cooper ML; Cheung SW; Justice MJ. 2008. Genotype, phenotype, and karyotype correlation in the XO mouse model of Turner Syndrome. J Hered 99(5):512-7. [PubMed: 18499648] [MGI Ref ID J:138994]

Smith DE; Xu SG. 2003. Ultrastructural organization of GABA-like immunoreactive profiles in the weaver substantia nigra. J Neurocytol 32(3):293-303. [PubMed: 14724391] [MGI Ref ID J:121345]

Vandenput L; Swinnen JV; Boonen S; Van Herck E; Erben RG; Bouillon R; Vanderschueren D. 2004. Role of the androgen receptor in skeletal homeostasis: the androgen-resistant testicular feminized male mouse model. J Bone Miner Res 19(9):1462-70. [PubMed: 15312246] [MGI Ref ID J:111491]

Wu Q; Miller RH; Ransohoff RM; Robinson S; Bu J; Nishiyama A. 2000. Elevated levels of the chemokine GRO-1 correlate with elevated oligodendrocyte progenitor proliferation in the jimpy mutant. J Neurosci 20(7):2609-17. [PubMed: 10729341] [MGI Ref ID J:109469]

Yamago G; Takata Y; Furuta I; Urase K; Momoi T; Huh N. 2001. Suppression of hair follicle development inhibits induction of sonic hedgehog, patched, and patched-2 in hair germs in mice. Arch Dermatol Res 293(9):435-41. [PubMed: 11758785] [MGI Ref ID J:116953]

Yoshida T; Katoh A; Ohtsuki G; Mishina M; Hirano T. 2004. Oscillating Purkinje neuron activity causing involuntary eye movement in a mutant mouse deficient in the glutamate receptor delta2 subunit. J Neurosci 24(10):2440-8. [PubMed: 15014119] [MGI Ref ID J:97010]

van Empel VP; Bertrand AT; van der Nagel R; Kostin S; Doevendans PA; Crijns HJ; de Wit E; Sluiter W; Ackerman SL; De Windt LJ. 2005. Downregulation of apoptosis-inducing factor in harlequin mutant mice sensitizes the myocardium to oxidative stress-related cell death and pressure overload-induced decompensation. Circ Res 96(12):e92-e101. [PubMed: 15933268] [MGI Ref ID J:110278]

a^e related

Barsh GS; Epstein CJ. 1989. Physical and genetic characterization of a 75-kilobase deletion associated with al, a recessive lethal allele at the mouse agouti locus. Genetics 121(4):811-8. [PubMed: 2566558] [MGI Ref ID J:9799]

Candille SI; Raamsdonk CD; Chen C; Kuijper S; Chen-Tsai Y; Russ A; Meijlink F; Barsh GS. 2004. Dorsoventral patterning of the mouse coat by tbx15. PLoS Biol 2(1):E3. [PubMed: 14737183] [MGI Ref ID J:87455]

Hollander WF; Gowen JW. 1956. An extreme non-agouti mutant in the mouse. J Hered 47:221-224. [MGI Ref ID J:13070]

Hustad CM; Perry WL; Siracusa LD; Rasberry C; Cobb L; Cattanach BM; Kovatch R; Copeland NG; Jenkins NA. 1995. Molecular genetic characterization of six recessive viable alleles of the mouse agouti locus. Genetics 140(1):255-65. [PubMed: 7635290] [MGI Ref ID J:24934]

Lyon MF; Fisher G; Glenister PH. 1985. A recessive allele of the mouse agouti locus showing lethality with yellow, Ay. Genet Res 46(1):95-9. [PubMed: 4065569] [MGI Ref ID J:8093]

Poole TW. 1975. Dermal-epidermal interactions and the action of alleles at the agouti locus in the mouse. Dev Biol 42(2):203-10. [PubMed: 1090472] [MGI Ref ID J:5519]

Silvers WK. 1979. The Coat Colors of Mice; A Model for Mammalian Gene Action and Interaction. In: The Coat Colors of Mice. Springer-Verlag, New York. [MGI Ref ID J:78801]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports
Room Number A1

Purchasing information

Pricing, Supply Level & Notes, Controls, General Terms & Conditions

Pricing

Pricing for USA, Canada and Mexico shipping destinations

Weeks of Age Price (US dollars $) Gender Genotypes Provided

Individual Mouse $134.40 Female or Male Compound Heterozygote for allele A^w-J and allele a^e

$134.40 Female or Male Homozygous for a^e

Pairs /Price (US dollars $) Pair Genotype

$268.80 Compound Heterozygote for allele A^w-J and allele a^e x Homozygous for a^e

$268.80 Homozygous for a^e x Compound Heterozygote for allele A^w-J and allele a^e

Weeks of Age	Price (US dollars $)	Gender	Genotypes Provided
Individual Mouse	$134.40	Female or Male	Compound Heterozygote for allele A^w-J and allele a^e
	$134.40	Female or Male	Homozygous for a^e

Pairs /Price (US dollars $)	Pair Genotype
$268.80	Compound Heterozygote for allele A^w-J and allele a^e x Homozygous for a^e
$268.80	Homozygous for a^e x Compound Heterozygote for allele A^w-J and allele a^e

Additional Supply Details

Pricing for International shipping destinations

Weeks of Age Price (US dollars $) Gender Genotypes Provided

Individual Mouse $174.80 Female or Male Compound Heterozygote for allele A^w-J and allele a^e

$174.80 Female or Male Homozygous for a^e

Pairs /Price (US dollars $) Pair Genotype

$349.50 Compound Heterozygote for allele A^w-J and allele a^e x Homozygous for a^e

$349.50 Homozygous for a^e x Compound Heterozygote for allele A^w-J and allele a^e

Weeks of Age	Price (US dollars $)	Gender	Genotypes Provided
Individual Mouse	$174.80	Female or Male	Compound Heterozygote for allele A^w-J and allele a^e
	$174.80	Female or Male	Homozygous for a^e

Pairs /Price (US dollars $)	Pair Genotype
$349.50	Compound Heterozygote for allele A^w-J and allele a^e x Homozygous for a^e
$349.50	Homozygous for a^e x Compound Heterozygote for allele A^w-J and allele a^e

Additional Supply Details

Supply Details

Standard Supply	Repository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of approximately nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within two business days following order placement.
Supply Notes	Usually shipped between four and eight weeks of age. This strain is included in the Mouse Mutant Resource collection. Genomic DNA is available for this strain from the Mouse DNA Resource.
Important Note
This strain is segregating for recessive a^e and dominant A^w-J.

Control Information


		For A^w-J: a^e/a^e from the colony For a^e: A^w-J/a^e from the colony

Considerations for Choosing Controls
USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains.
International - Control Pricing Information for Genetically Engineered Mutant Strains.

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Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.

See Terms of Use tab for General Terms and Conditions

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

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Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
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phone:	207-288-6470
fax:	207-288-6655

JAX^® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. In purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.

000202	AEJ/Gn-bd/J
000593	B6 x B6CBCa A^w-J/A-Grid2^Lc T(2;6)7Ca Mitf^Mi-wh/J
000502	B6 x B6CBCa A^w-J/A-Myo5a^flr Gnb5^flr/J
000599	B6 x B6CBCa A^w-J/A-T(5;13)264Ca Kit^W-v/J
002016	B6(Cg)-A^w-J Eda^Ta-6J Chr Y^B6-Sxr/EiJ
000552	B6-A^w-J-Eda^Ta-6J.Cg-Sxr
001730	B6-A^w-J-Eda^Ta-6J.Cg-Sxr^b Hya^-/J
000841	B6-A^w-J.CBy-Eda^Ta-By/J
001809	B6-A^w-J.Cg-Eda^Ta-6J +/+ Ar^Tfm/J
000600	B6-Gpi1^b x B6CBCa A^w-J/A-T(7;15)9H Gpi1^a/J
100409	B6129PF1/J-A^w-J/A^w
004200	B6;CBACa A^w-J/A-Npr2^cn-2J/GrsrJ
000505	B6C3 A^w-J/A-Muted^mu/J
000314	B6CBACa A^w-J/A-Eda^Ta/J-XO
000501	B6CBACa A^w-J/A-Aifm1^Hq/J
001046	B6CBACa A^w-J/A-Grid2^Lc/J
000500	B6CBACa A^w-J/A-Gs/J
002703	B6CBACa A^w-J/A-Hydin^hy3/J
000247	B6CBACa A^w-J/A-Kcnj6^wv/J
000287	B6CBACa A^w-J/A-Plp1^jp Eda^Ta/J
000515	B6CBACa A^w-J/A-Sfn^Er/J
000242	B6CBACa A^w-J/A-spc/J
000288	B6CBACa A^w-J/A-we a Mafb^kr/J
001201	B6CBACaF1/J-A^w-J/A
001752	B6CBCa A^w-J/A-T(7;15)9H/J
000200	C3FeB6 A/A^w-J-Ank^ank/J
000638	C3FeB6 A/A^w-J-Spnb4^qv-J/J
001203	C3FeB6F1/J A/A^w-J
000338	C57BL/6J A^w-J-Eda^Ta-6J/J
000569	C57BL/6J-A^w-J-Eda^Ta +/+ Ar^Tfm/J
000051	C57BL/6J-A^w-J/J

003301	(C57BL/6J x C3H-Eya1^bor)F1/J
000433	B10.C-H3^c H13^? A/(28NX)SnJ
000427	B10.CE-H13^b A^w/(30NX)SnJ
000423	B10.KR-H13^? A/SnJ
000420	B10.LP-H13^b A^w/Sn
000477	B10.PA-Pldn^pa H3^e a^t/SnJ
000419	B10.UW-H3^b we Pax1^un a^t/SnJ
003879	B10;TFLe-a/a T tf/+ tf/J
001538	B6 x B6C3Sn a/A-T(1;9)27H/J
000916	B6 x B6C3Sn a/A-T(5;12)31H/J
000602	B6 x B6C3Sn a/A-T(8;16)17H/J
002083	B6 x B6EiC3 a/A-T(7;16)235Dn/J
000507	B6 x B6EiC3 a/A-Otc^spf/J
003759	B6 x B6EiC3Sn a/A-T(10;16)232Dn/J
002071	B6 x B6EiC3Sn a/A-T(11;17)202Dn/J
002113	B6 x B6EiC3Sn a/A-T(11A2;16B3)238Dn/J
002068	B6 x B6EiC3Sn a/A-T(11B1;16B5)233Dn/J
002069	B6 x B6EiC3Sn a/A-T(14E4or5;16B5)225Dn/J
001926	B6 x B6EiC3Sn a/A-T(15;16)198Dn/J
001832	B6 x B6EiC3Sn a/A-T(15E;16B1)60Dn/J
003758	B6 x B6EiC3Sn a/A-T(16C3-4;17A2)65Dn/J
001833	B6 x B6EiC3Sn a/A-T(1C2;16C3)45Dn/J
001903	B6 x B6EiC3Sn a/A-T(6F;18C)57Dn/J
001535	B6 x B6EiC3Sn a/A-T(8A4;12D1)69Dn/J
001831	B6 x B6EiC3Sn a/A-T(8C3;16B5)164Dn/J
000618	B6 x FSB/GnEi a/a Ctsl^fs/J
000577	B6 x STOCK a Oca2^p Hps5^ru2 Ednrb^s/J
000601	B6 x STOCK a/a T(7;18)50H/J
000592	B6 x STOCK T(2;4)13H a/J
000769	B6.C/(HZ18)By-a^t-44J/J
000001	B6.C3 A/a Mgrn1^md/J
000203	B6.C3-A^iy/a/J
000017	B6.C3-A^vy/J
001572	B6.C3-a^m-J/J
000628	B6.CE-A Amy1^b Amy2a5^b/J
000021	B6.Cg-A^y/J
000231	B6;C3Fe a/a-Csf1^op/J
004200	B6;CBACa A^w-J/A-Npr2^cn-2J/GrsrJ
000785	B6;D2-a Es1^e/EiJ
000604	B6C3 a/A-T(10;13)199H +/+ Lyst^bg-J/J or Lyst^bg-2J/J
002807	B6C3Fe a/a-Meox2^fla/J
000224	B6C3Fe a/a-Scyl1^mdf/J
001037	B6C3Fe a/a-Agtpbp1^pcd/J
000221	B6C3Fe a/a-Alx4^lst-J/J
002062	B6C3Fe a/a-Atp7a^Mo-8J/J
001756	B6C3Fe a/a-Cacng2^stg/J
001815	B6C3Fe a/a-Col1a2^oim/J
000209	B6C3Fe a/a-Dh/J
000211	B6C3Fe a/a-Dst^dt-J/J
000210	B6C3Fe a/a-Edar^dl-J/J
000207	B6C3Fe a/a-Edaradd^cr/J
000182	B6C3Fe a/a-Eef1a2^wst/J
001278	B6C3Fe a/a-Glra1^spd/J
000241	B6C3Fe a/a-Glrb^spa/J
002875	B6C3Fe a/a-Hoxd13^spdh/J
000304	B6C3Fe a/a-Krt71^Ca Scn8a^med-J/J
000226	B6C3Fe a/a-Large^myd/J
000636	B6C3Fe a/a-Lmx1a^dr-J/J
001280	B6C3Fe a/a-Lse/J
001573	B6C3Fe a/a-Mitf^Mi/J
001035	B6C3Fe a/a-Napa^hyh/J
000181	B6C3Fe a/a-Otog^twt/J
000278	B6C3Fe a/a-Papss2^bm Hps1^ep Hps6^ru/J
000205	B6C3Fe a/a-Papss2^bm/J
002078	B6C3Fe a/a-Pcdh15^av-2J/J
000246	B6C3Fe a/a-Pitpna^vb/J
001430	B6C3Fe a/a-Ptch1^mes/J
000506	B6C3Fe a/a-Qk^qk/J
000235	B6C3Fe a/a-Reln^rl/J
000237	B6C3Fe a/a-Rora^sg/J
000290	B6C3Fe a/a-Sox10^Dom/J
000230	B6C3Fe a/a-Tcirg1^oc/J
003612	B6C3Fe a/a-Trak1^hyrt/J
001512	B6C3Fe a/a-Ttn^mdm/J
001607	B6C3Fe a/a-Unc5c^rcm/J
000005	B6C3Fe a/a-Wc/J
000243	B6C3Fe a/a-Wnt1^sw/J
000248	B6C3Fe a/a-Xpl/J
001750	B6C3Fe a/a-Xs^J/J
000624	B6C3Fe a/a-anx/J
008044	B6C3Fe a/a-bpck/J
003020	B6C3Fe a/a-dep/J
002018	B6C3Fe a/a-din/J
002339	B6C3Fe a/a-nma/J
000240	B6C3Fe a/a-soc/J
000063	B6C3Fe a/a-sy/J
001055	B6C3Fe a/a-tip/J
000245	B6C3Fe a/a-tn/J
000065	B6C3Fe a/a-we Pax1^un a^t/J
000296	B6C3Fe-a/a Hoxa13^Hd Mcoln3^Va-J/J
000019	B6C3Fe-a/a-Itpr1^opt/J
001022	B6C3FeF1/J a/a
001752	B6CBCa A^w-J/A-T(7;15)9H/J
006450	B6EiC3 a/A-Vss/GrsrJ
000971	B6EiC3 a/A-Och/J
000551	B6EiC3 a/A-Tbx15^de-H/J
000557	B6EiC3-+ a/Lnp^Ul A/J
000504	B6EiC3Sn a/A-Cacnb4^lh/J
000553	B6EiC3Sn a/A-Egfr^wa2 Wnt3a^vt/J
000503	B6EiC3Sn a/A-Gy/J
001811	B6EiC3Sn a/A-Otc^spf-ash/J
002343	B6EiC3Sn a/A-Otc^spf/J
000391	B6EiC3Sn a/A-Pax6^Sey-Dey/J
001924	B6EiC3Sn a/A-Ts(17¹⁶)65Dn
001923	B6EiC3Sn a/A-Ts(4¹⁷)2Lws Tim/J
001875	B6EiC3SnF1/J
000200	C3FeB6 A/A^w-J-Ank^ank/J
000638	C3FeB6 A/A^w-J-Spnb4^qv-J/J
000225	C3FeLe.B6 a/a-Ptpn6^me/J
008425	C3FeLe.B6-a Trl/J
000198	C3FeLe.B6-a/J
000291	C3FeLe.Cg-a/a Hm Kitl^Sl Krt71^Ca-J/J
001272	C3H/HeSnJ-A^hvy/J
000099	C3HeB/FeJ-A^vy/J
001886	C3HeB/FeJLe a/a-gnd/J
000584	C57BL/6J-+ T(1;2)5Ca/a +/J
000258	C57BL/6J-Aⁱ/a/J
000774	C57BL/6J-A^sy/a/J
000055	C57BL/6J-a^t-33J/J
000070	C57BL/6J-a^td/J
000284	CWD/LeJ
000670	DBA/1J
000671	DBA/2J
001057	HPT/LeJ
000260	JGBF/LeJ
002468	KK.Cg-A^y/J
000262	LS/LeJ
000283	LT.CAST-A/J
000265	MY/HuLeJ
000308	SSL/LeJ
001759	STOCK A Tyr^c Sha/J
001427	STOCK A^w us/J
000994	STOCK a Myo5a^d Mreg^dsu/J
000064	STOCK a Tyrp1^b Si^si/J
002238	STOCK a Tyrp1^b shmy/J
001433	STOCK a skt/J
000579	STOCK a tp/J
000319	STOCK a us/J
002648	STOCK a/a Cln6^nclf/J
000317	STOCK a/a Egfr^wa2/J
000302	STOCK a/a Mitf^Mi-wh +/+ Itpr1^opt/J
000286	STOCK a/a Myo5a^d fd/+ +/J
000206	STOCK a/a Tyr^c-h/J
001432	STOCK a/a Tyrp1^b sks/Tyrp1^b +/J
000281	STOCK a/a ma Flg^ft/ma Flg^ft/J
000312	STOCK stb + a/+ Fign^fi a/J
000596	STOCK T(2;11)30H/+ x AEJ-a Gdf5^bp-H/J or A/J-a Gdf5^bp-J/J
000970	STOCK T(2;16)28H A/T(2;16)28H a/J
000590	STOCK T(2;4)1Sn a/J
000594	STOCK T(2;8)26H a/T(2;8)26H a Tyrp1⁺/Tyrp1^b/J
000623	TR/DiEiJ

Strain Name:

AEJ/GnLeJ

Stock Number:

000199

Availability:

Repository- Live

Strain Information

Control Information

Related Strains

Phenotype Information

ae/ae

Gene & Allele Information

Genotyping Information

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References

Additional References

Health & Colony Maintenance Information

Animal Health Reports

Pricing, Supply Level & Notes, Controls, General Terms & Conditions

Pricing

Additional Supply Details

Additional Supply Details

Supply Details

Control Information

Payment Terms and Conditions

See Terms of Use tab for General Terms and Conditions

The Jackson Laboratory's Genotype Promise

Terms of Use

Contact information

Contracts Administration

JAX® Mice, Products & Services Conditions of Use

No Warranty

No Liability

a^e/a^e

JAX^® Mice, Products & Services Conditions of Use