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Genes & Alleles

Aw-J;   a;   ae;   bd;

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Product Information

Strain Details

Type JAX® GEMM® Strain - Mutant Strain Additional information on JAX® GEMM® Strains. Type JAX® GEMM® Strain - Spontaneous Mutation Species laboratory mouse Generation F61

Important Note
This strain is segregating for recessive a^e and dominant A^w-J.

Mammalian Phenotype Terms assigned by genotype bd/bd         AEJ lethality-postnatal postnatal lethality (MGI Ref ID J:65322) severely affected animals die within the first 2 weeks after birth, some animals survive to adulthood 25% of mutants survive to weaning; infrequently a mouse survives to breeding age and is fertile digestive/alimentary phenotype abnormal intestine morphology (MGI Ref ID J:65322) large amounts of gas in the intestines abnormal stomach morphology (MGI Ref ID J:65322) large amounts of gas in the stomach growth/size phenotype abnormal body weight (MGI Ref ID J:65322) variable weight reduction, compared to wild-type, begins at 3-5 days of age decreased body size (MGI Ref ID J:5862) postnatal growth retardation (MGI Ref ID J:65322) growth retardation is apparent at 3-5 days after birth renal/urinary system phenotype dilated renal tubules (MGI Ref ID J:65322) respiratory system phenotype emphysema (MGI Ref ID J:65322) hypopnea (MGI Ref ID J:5862) breathing rate is 50% of normal, accompanied by increased depth of inspiration with the same amount of oxygen consumption per unit of body surface as wild-type mice cardiovascular system phenotype abnormal right atrium morphology (MGI Ref ID J:65322) enlarged right atrium

Gene & Allele Details

Allele Symbol		bd
Allele Name		bradypneic
Strain of Origin		AEJ
Allele Symbol		Aw-J
Allele Name		white bellied agouti Jackson
Common Name(s)		AWJ;
Strain of Origin		C57BL/6J
Gene Symbol and Name		a, nonagouti
Chromosome		2
Gene Common Name(s)		AGSW; AGTI; AGTIL; ASP; As; MGC126092; MGC126093; SHEP9; agouti; agouti signal protein; agouti suppressor;
Allele Symbol		ae
Allele Name		extreme nonagouti
Strain of Origin		(P x S)F1
Gene Symbol and Name		a, nonagouti
Chromosome		2
Gene Common Name(s)		AGSW; AGTI; AGTIL; ASP; As; MGC126092; MGC126093; SHEP9; agouti; agouti signal protein; agouti suppressor;
General Note		The ae mutation was found among descendants of an irradiated mouse. ae is recessive to all other alleles except al.

Control Information

Allele	Control
bd	Untyped from the colony
Considerations for Choosing Controls

Genotyping Protocols

A^w-J

Related Strains

Strains carrying   A^w-J allele

000199	AEJ/GnLeJ
000593	B6 x B6CBCa Aw-J/A-Grid2Lc T(2;6)7Ca MitfMi-wh/J
000502	B6 x B6CBCa Aw-J/A-Myo5aflr Gnb5flr/J
000599	B6 x B6CBCa Aw-J/A-T(5;13)264Ca KitW-v/J
002016	B6(Cg)-Aw-J EdaTa-6J Chr YB6-Sxr/EiJ
000552	B6-Aw-J-EdaTa-6J.Cg-Sxr
001730	B6-Aw-J-EdaTa-6J.Cg-Sxrb Hya-/J
000841	B6-Aw-J.CBy-EdaTa-By/J
001809	B6-Aw-J.Cg-EdaTa-6J +/+ ArTfm/J
000600	B6-Gpi1b x B6CBCa Aw-J/A-T(7;15)9H Gpi1a/J
100409	B6129PF1/J-Aw-J/Aw
004200	B6;CBACa Aw-J/A-Npr2cn-2J/J
000505	B6C3 Aw-J/A-Mutedmu/J
000314	B6CBACa Aw-J/A-EdaTa/J-XO
000501	B6CBACa Aw-J/A-Aifm1Hq/J
001046	B6CBACa Aw-J/A-Grid2Lc/J
000500	B6CBACa Aw-J/A-Gs/J
002703	B6CBACa Aw-J/A-Hydinhy3/J
000247	B6CBACa Aw-J/A-Kcnj6wv/J
000287	B6CBACa Aw-J/A-Plp1jp EdaTa/J
000515	B6CBACa Aw-J/A-SfnEr/J
000242	B6CBACa Aw-J/A-spc/J
000288	B6CBACa Aw-J/A-we a Mafbkr/J
001201	B6CBACaF1/J-Aw-J/A
001752	B6CBCa Aw-J/A-T(7;15)9H/J
000200	C3FeB6 A/Aw-J-Ankank/J
000638	C3FeB6 A/Aw-J-Spnb4qv-J/J
001203	C3FeB6F1/J A/Aw-J
000338	C57BL/6J Aw-J-EdaTa-6J/J
000569	C57BL/6J-Aw-J-EdaTa +/+ ArTfm/J
000051	C57BL/6J-Aw-J/J

View Strains carrying   A^w-J     (31 strains)

Strains carrying   a^e allele

000251	AEJ.Cg-ae +/a Gdf5bp-H/J
000199	AEJ/GnLeJ

View Strains carrying   a^e     (2 strains)

Strains carrying other alleles of a

003301	(C57BL/6J x C3H-Eya1bor)F1/J
000427	B10.CE-H13b Aw/(30NX)SnJ
000420	B10.LP-H13b Aw/Sn
000477	B10.PA-Pldnpa H3e at/SnJ
000419	B10.UW-H3b we Pax1un at/SnJ
003879	B10;TFLe-a/a T tf/+ tf/J
001538	B6 x B6C3Sn a/A-T(1;9)27H/J
000916	B6 x B6C3Sn a/A-T(5;12)31H/J
000602	B6 x B6C3Sn a/A-T(8;16)17H/J
002083	B6 x B6EiC3 a/A-T(7;16)235Dn/J
000507	B6 x B6EiC3 a/A-Otcspf/J
000618	B6 x FSB/GnEi a/a Ctslfs/J
000577	B6 x STOCK a Oca2p Hps5ru2 Ednrbs/J
000601	B6 x STOCK a/a T(7;18)50H/J
000592	B6 x STOCK T(2;4)13H a/J
000769	B6.C/(HZ18)By-at-44J/J
000001	B6.C3 A/a Mgrn1md/J
000203	B6.C3-Aiy/a/J
000017	B6.C3Fe-Avy/J
000628	B6.CE-A Amy1b Amy2b/J
005505	B6.Cg-Ay Slc7a11sut/LmLlp
000021	B6.Cg-Ay/J
001572	B6.Cg-am-J/J
004200	B6;CBACa Aw-J/A-Npr2cn-2J/J
000785	B6;D2-a Es1e/J
000604	B6C3 a/A-T(10;13)199H +/+ Lystbg-J/J or Lystbg-2J/J
002807	B6C3Fe a/a-Meox2fla/J
000224	B6C3Fe a/a-Scyl1mdf/J
001037	B6C3Fe a/a-Agtpbp1pcd/J
000221	B6C3Fe a/a-Alx4lst-J/J
002062	B6C3Fe a/a-Atp7aMo-8J/J
001756	B6C3Fe a/a-Cacng2stg/J
001815	B6C3Fe a/a-Col1a2oim/J
000231	B6C3Fe a/a-Csf1op/J
000209	B6C3Fe a/a-Dh/J
000211	B6C3Fe a/a-Dstdt-J/J
000210	B6C3Fe a/a-Edardl-J/J
000207	B6C3Fe a/a-Edaraddcr/J
000182	B6C3Fe a/a-Eef1a2wst/J
001278	B6C3Fe a/a-Glra1spd/J
000241	B6C3Fe a/a-Glrbspa/J
002875	B6C3Fe a/a-Hoxd13spdh/J
000304	B6C3Fe a/a-Krt71Ca Scn8amed-J/J
000226	B6C3Fe a/a-Largemyd/J
000636	B6C3Fe a/a-Lmx1adr-J/J
001280	B6C3Fe a/a-Lse/J
001573	B6C3Fe a/a-MitfMi/J
001035	B6C3Fe a/a-Napahyh/J
000181	B6C3Fe a/a-Otogtwt/J
000278	B6C3Fe a/a-Papss2bm Hps1ep Hps6ru/J
000205	B6C3Fe a/a-Papss2bm/J
002078	B6C3Fe a/a-Pcdh15av-2J/J
000246	B6C3Fe a/a-Pitpnavb/J
001430	B6C3Fe a/a-Ptch1mes/J
000506	B6C3Fe a/a-Qkqk/J
000235	B6C3Fe a/a-Relnrl/J
000237	B6C3Fe a/a-Rorasg/J
000290	B6C3Fe a/a-Sox10Dom/J
000230	B6C3Fe a/a-Tcirg1oc/J
003612	B6C3Fe a/a-Trak1hyrt/J
001512	B6C3Fe a/a-Ttnmdm/J
001607	B6C3Fe a/a-Unc5crcm/J
000005	B6C3Fe a/a-Wc/J
000243	B6C3Fe a/a-Wnt1sw/J
000248	B6C3Fe a/a-Xpl/J
001750	B6C3Fe a/a-XsJ/J
000624	B6C3Fe a/a-anx/J
003020	B6C3Fe a/a-dep/J
002018	B6C3Fe a/a-din/J
002339	B6C3Fe a/a-nma/J
000240	B6C3Fe a/a-soc/J
000063	B6C3Fe a/a-sy/J
001055	B6C3Fe a/a-tip/J
000245	B6C3Fe a/a-tn/J
000065	B6C3Fe a/a-we Pax1un at/J
000296	B6C3Fe-a/a Hoxa13Hd Mcoln3Va-J/J
000019	B6C3Fe-a/a-Itpr1opt/J
001022	B6C3FeF1/J a/a
001752	B6CBCa Aw-J/A-T(7;15)9H/J
000971	B6EiC3 a/A-Och/J
000551	B6EiC3 a/A-Tbx15de-H/J
006450	B6EiC3 a/A-Vss/J
000557	B6EiC3-+ a/LnpUl A/J
000504	B6EiC3Sn a/A-Cacnb4lh/J
000553	B6EiC3Sn a/A-Egfrwa2 Wnt3avt/J
000503	B6EiC3Sn a/A-Gy/J
001811	B6EiC3Sn a/A-Otcspf-ash/J
002343	B6EiC3Sn a/A-Otcspf/J
000391	B6EiC3Sn a/A-Pax6Sey-Dey/J
001924	B6EiC3Sn a/A-Ts(1716)65Dn
001923	B6EiC3Sn a/A-Ts(417)2Lws Tim/J
000200	C3FeB6 A/Aw-J-Ankank/J
000638	C3FeB6 A/Aw-J-Spnb4qv-J/J
000225	C3FeLe.B6 a/a-Ptpn6me/J
000198	C3FeLe.B6-a/J
000291	C3FeLe.Cg-a/a Hm KitlSl Krt71Ca-J/J
001272	C3H/HeSnJ-Ahvy/J
000099	C3HeB/FeJ-Avy/J
001886	C3HeB/FeJLe a/a-gnd/J
000584	C57BL/6J-+ T(1;2)5Ca/a +/J
000258	C57BL/6J-Ai/a/J
000774	C57BL/6J-Asy/a/J
000055	C57BL/6J-at-33J/J
000070	C57BL/6J-atd/J
000284	CWD/LeJ
000670	DBA/1J
000671	DBA/2J
001057	HPT/LeJ
000260	JGBF/LeJ
002468	KK.Cg-Ay/J
000262	LS/LeJ
000283	LT.CAST-A/J
000265	MY/HuLeJ
000308	SSL/LeJ
001759	STOCK A Tyrc Sha/J
001427	STOCK Aw us/J
000994	STOCK a Myo5ad Mregdsu/J
000064	STOCK a Tyrp1b Sisi/J
002238	STOCK a Tyrp1b shmy/J
001433	STOCK a skt/J
000579	STOCK a tp/J
000319	STOCK a us/J
002648	STOCK a/a Cln6nclf/J
000317	STOCK a/a Egfrwa2/J
000302	STOCK a/a MitfMi-wh +/+ Itpr1opt/J
000286	STOCK a/a Myo5ad fd/+ +/J
000206	STOCK a/a Tyrc-h/J
001432	STOCK a/a Tyrp1b sks/Tyrp1b +/J
000281	STOCK a/a ma ft/ma ft/J
000312	STOCK stb + a/+ Fignfi a/J
000596	STOCK T(2;11)30H/+ x AEJ-a Gdf5bp-H/J or A/J-a Gdf5bp-J/J
000970	STOCK T(2;16)28H A/T(2;16)28H a/J
000590	STOCK T(2;4)1Sn a/J
000594	STOCK T(2;8)26H a/T(2;8)26H a Tyrp1+/Tyrp1b/J
000623	TR/DiEiJ

View Strains carrying other alleles of a     (135 strains)

Research Applications

This mouse can be used to support research in many areas including:

a^e related

Dermatology Research
Color and White Spotting Defects

bd related

Internal/Organ Research
Gastrointestinal Defects
Lung Defects

References

Additional References

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Price and Supply Information

Strain Name:	AEJ/Gn-bd/J
Stock Number:	000202

Price Details

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Supply Details

Standard Supply	Repository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information.
Supply Notes	Cryorecovery - Standard. The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two males and two females (two pairs) will be provided, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the delivery time to approximately 25 weeks. At least one member of each pair will be of known genotype and will carry the mutation if it is a mutant strain. Please note that pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Price represents a repository maintenance fee, which includes the cost of recovery of the strain from the cryopreservation resource and the periodic replacement of the frozen embryos used for recovery. Cryorecovery to establish a Dedicated Supply for greater quantities of mice. One to two pairs will be recovered to establish a Dedicated Supply of mice. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services: Tel: 1-800-422-6423 or 1-207-288-5845; Email: jaxservices@jax.org. Genomic DNA is available for this strain from the Mouse DNA Resource.
Licensing	See General Terms and Conditions below
Control Information	View Control Information in Strain Details.

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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

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