Strain Name:

B6C3Fe a/a-Edaraddcr/J

Stock Number:

000207

Availability:

Cryopreserved - Ready for recovery

Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Former Names B6C3Fe-a/a-Edaraddcr    (Changed: 15-DEC-04 )
Type Mutant Stock;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Mating SystemOutcross-Intercross         (Female x Male)   01-MAR-06
TJL Breeding Summary: homozyogote x B6C3Fe a/a F1 then obligate heterozygote x heterozygote
Specieslaboratory mouse
GenerationN34p

Appearance
black
Related Genotype: a/a Edaraddcr/+ or a/a +/?

black, aberrent coat and teeth
Related Genotype: a/a Edaraddcr/Edaraddcr

Control Information

  Control
   +/? from the colony
 
  Considerations for Choosing Controls

Related Strains

Strains carrying   a allele
003879   B10;TFLe-a/a T tf/+ tf/J
001538   B6 x B6C3Sn a/A-T(1;9)27H/J
000916   B6 x B6C3Sn a/A-T(5;12)31H/J
000602   B6 x B6C3Sn a/A-T(8;16)17H/J
000618   B6 x FSB/GnEi a/a Ctslfs/J
000577   B6 x STOCK a Oca2p Hps5ru2 Ednrbs/J
000601   B6 x STOCK a/a T(7;18)50H/J
000592   B6 x STOCK T(2;4)13H a/J
000001   B6.C3 A/a Mgrn1md/J
000231   B6;C3Fe a/a-Csf1op/J
000785   B6;D2-a Es1e/EiJ
000604   B6C3 a/A-T(10;13)199H +/+ Lystbg-J/J or Lystbg-2J/J
002807   B6C3Fe a/a-Meox2fla/J
000224   B6C3Fe a/a-Scyl1mdf/J
001037   B6C3Fe a/a-Agtpbp1pcd/J
000221   B6C3Fe a/a-Alx4lst-J/J
002062   B6C3Fe a/a-Atp7aMo-8J/J
001756   B6C3Fe a/a-Cacng2stg/J
001815   B6C3Fe a/a-Col1a2oim/J
000209   B6C3Fe a/a-Dh/J
000211   B6C3Fe a/a-Dstdt-J/J
000210   B6C3Fe a/a-Edardl-J/J
000182   B6C3Fe a/a-Eef1a2wst/J
001278   B6C3Fe a/a-Glra1spd/J
000241   B6C3Fe a/a-Glrbspa/J
002875   B6C3Fe a/a-Hoxd13spdh/J
000304   B6C3Fe a/a-Krt71Ca Scn8amed-J/J
000226   B6C3Fe a/a-Largemyd/J
000636   B6C3Fe a/a-Lmx1adr-J/J
001280   B6C3Fe a/a-Lse/J
001573   B6C3Fe a/a-MitfMi/J
001035   B6C3Fe a/a-Napahyh/J
000181   B6C3Fe a/a-Otogtwt/J
000278   B6C3Fe a/a-Papss2bm Hps1ep Hps6ru/J
000205   B6C3Fe a/a-Papss2bm/J
002078   B6C3Fe a/a-Pcdh15av-2J/J
000246   B6C3Fe a/a-Pitpnavb/J
001430   B6C3Fe a/a-Ptch1mes/J
000506   B6C3Fe a/a-Qkqk/J
000235   B6C3Fe a/a-Relnrl/J
000237   B6C3Fe a/a-Rorasg/J
000290   B6C3Fe a/a-Sox10Dom/J
000230   B6C3Fe a/a-Tcirg1oc/J
003612   B6C3Fe a/a-Trak1hyrt/J
001512   B6C3Fe a/a-Ttnmdm/J
001607   B6C3Fe a/a-Unc5crcm/J
000005   B6C3Fe a/a-Wc/J
000243   B6C3Fe a/a-Wnt1sw/J
000248   B6C3Fe a/a-Xpl/J
001750   B6C3Fe a/a-XsJ/J
000624   B6C3Fe a/a-anx/J
008044   B6C3Fe a/a-bpck/J
003020   B6C3Fe a/a-dep/J
002018   B6C3Fe a/a-din/J
002339   B6C3Fe a/a-nma/J
000240   B6C3Fe a/a-soc/J
000063   B6C3Fe a/a-sy/J
001055   B6C3Fe a/a-tip/J
000245   B6C3Fe a/a-tn/J
000296   B6C3Fe-a/a Hoxa13Hd Mcoln3Va-J/J
000019   B6C3Fe-a/a-Itpr1opt/J
001022   B6C3FeF1/J a/a
006450   B6EiC3 a/A-Vss/GrsrJ
000971   B6EiC3 a/A-Och/J
000551   B6EiC3 a/A-Tbx15de-H/J
000557   B6EiC3-+ a/LnpUl A/J
000503   B6EiC3Sn a/A-Gy/J
001811   B6EiC3Sn a/A-Otcspf-ash/J
002343   B6EiC3Sn a/A-Otcspf/J
000391   B6EiC3Sn a/A-Pax6Sey-Dey/J
001924   B6EiC3Sn a/A-Ts(1716)65Dn
001923   B6EiC3Sn a/A-Ts(417)2Lws TimT(4;17)3Lws/J
000225   C3FeLe.B6 a/a-Ptpn6me/J
008425   C3FeLe.B6-a Trl/J
000198   C3FeLe.B6-a/J
000291   C3FeLe.Cg-a/a Hm KitlSl Krt71Ca-J/J
001886   C3HeB/FeJLe a/a-gnd/J
000584   C57BL/6J-+ T(1;2)5Ca/a +/J
000284   CWD/LeJ
000670   DBA/1J
000671   DBA/2J
001057   HPT/LeJ
000260   JGBF/LeJ
000265   MY/HuLeJ
000308   SSL/LeJ
000994   STOCK a Myo5ad Mregdsu/J
000064   STOCK a Tyrp1b Sisi/J
002238   STOCK a Tyrp1b shmy/J
001433   STOCK a skt/J
000579   STOCK a tp/J
000319   STOCK a us/J
002648   STOCK a/a Cln6nclf/J
000317   STOCK a/a Egfrwa2/J
000302   STOCK a/a MitfMi-wh +/+ Itpr1opt/J
000286   STOCK a/a Myo5ad fd/+ +/J
000206   STOCK a/a Tyrc-h/J
001432   STOCK a/a Tyrp1b sks/Tyrp1b +/J
000281   STOCK a/a ma Flgft/ma Flgft/J
000312   STOCK stb + a/+ Fignfi a/J
000596   STOCK T(2;11)30H/+ x AEJ-a Gdf5bp-H/J or A/J-a Gdf5bp-J/J
000970   STOCK T(2;16)28H A/T(2;16)28H a/J
000590   STOCK T(2;4)1Sn a/J
000594   STOCK T(2;8)26H a/T(2;8)26H a Tyrp1+/Tyrp1b/J
000623   TR/DiEiJ
View Strains carrying   a     (104 strains)

Strains carrying other alleles of Edaradd
004184   STOCK Tg(Wap-HRAS)69Lln Chr YSJL-Edaraddcr-3J/J
View Strains carrying other alleles of Edaradd     (1 strain)

Strains carrying other alleles of a
003301   (C57BL/6J x C3H-Eya1bor)F1/J
000251   AEJ.Cg-ae +/a Gdf5bp-H/J
000202   AEJ/Gn-bd/J
000199   AEJ/GnLeJ
000433   B10.C-H3c H13? A/(28NX)SnJ
000427   B10.CE-H13b Aw/(30NX)SnJ
000423   B10.KR-H13? A/SnJ
000420   B10.LP-H13b Aw/Sn
000477   B10.PA-Pldnpa H3e at/SnJ
000419   B10.UW-H3b we Pax1un at/SnJ
000593   B6 x B6CBCa Aw-J/A-Grid2Lc T(2;6)7Ca MitfMi-wh/J
000502   B6 x B6CBCa Aw-J/A-Myo5aflr Gnb5flr/J
000599   B6 x B6CBCa Aw-J/A-T(5;13)264Ca KitW-v/J
002083   B6 x B6EiC3 a/A-T(7;16)235Dn/J
000507   B6 x B6EiC3 a/A-Otcspf/J
003759   B6 x B6EiC3Sn a/A-T(10;16)232Dn/J
002071   B6 x B6EiC3Sn a/A-T(11;17)202Dn/J
002113   B6 x B6EiC3Sn a/A-T(11A2;16B3)238Dn/J
002068   B6 x B6EiC3Sn a/A-T(11B1;16B5)233Dn/J
002069   B6 x B6EiC3Sn a/A-T(14E4or5;16B5)225Dn/J
001926   B6 x B6EiC3Sn a/A-T(15;16)198Dn/J
001832   B6 x B6EiC3Sn a/A-T(15E;16B1)60Dn/J
003758   B6 x B6EiC3Sn a/A-T(16C3-4;17A2)65Dn/J
001833   B6 x B6EiC3Sn a/A-T(1C2;16C3)45Dn/J
001903   B6 x B6EiC3Sn a/A-T(6F;18C)57Dn/J
001535   B6 x B6EiC3Sn a/A-T(8A4;12D1)69Dn/J
001831   B6 x B6EiC3Sn a/A-T(8C3;16B5)164Dn/J
002016   B6(Cg)-Aw-J EdaTa-6J Chr YB6-Sxr/EiJ
000552   B6-Aw-J-EdaTa-6J.Cg-Sxr
001730   B6-Aw-J-EdaTa-6J.Cg-Sxrb Hya-/J
000841   B6-Aw-J.CBy-EdaTa-By/J
001809   B6-Aw-J.Cg-EdaTa-6J +/+ ArTfm/J
000600   B6-Gpi1b x B6CBCa Aw-J/A-T(7;15)9H Gpi1a/J
000769   B6.C/(HZ18)By-at-44J/J
000203   B6.C3-Aiy/a/J
000017   B6.C3-Avy/J
001572   B6.C3-am-J/J
000628   B6.CE-A Amy1b Amy2a5b/J
000021   B6.Cg-Ay/J
100409   B6129PF1/J-Aw-J/Aw
004200   B6;CBACa Aw-J/A-Npr2cn-2J/GrsrJ
000505   B6C3 Aw-J/A-Mutedmu/J
000604   B6C3 a/A-T(10;13)199H +/+ Lystbg-J/J or Lystbg-2J/J
000065   B6C3Fe a/a-we Pax1un at/J
000314   B6CBACa Aw-J/A-EdaTa/J-XO
000501   B6CBACa Aw-J/A-Aifm1Hq/J
001046   B6CBACa Aw-J/A-Grid2Lc/J
000500   B6CBACa Aw-J/A-Gs/J
002703   B6CBACa Aw-J/A-Hydinhy3/J
000247   B6CBACa Aw-J/A-Kcnj6wv/J
000287   B6CBACa Aw-J/A-Plp1jp EdaTa/J
000515   B6CBACa Aw-J/A-SfnEr/J
000242   B6CBACa Aw-J/A-spc/J
000288   B6CBACa Aw-J/A-we a Mafbkr/J
001201   B6CBACaF1/J-Aw-J/A
001752   B6CBCa Aw-J/A-T(7;15)9H/J
006450   B6EiC3 a/A-Vss/GrsrJ
000557   B6EiC3-+ a/LnpUl A/J
000504   B6EiC3Sn a/A-Cacnb4lh/J
000553   B6EiC3Sn a/A-Egfrwa2 Wnt3avt/J
001811   B6EiC3Sn a/A-Otcspf-ash/J
002343   B6EiC3Sn a/A-Otcspf/J
001923   B6EiC3Sn a/A-Ts(417)2Lws TimT(4;17)3Lws/J
001875   B6EiC3SnF1/J
000200   C3FeB6 A/Aw-J-Ankank/J
000638   C3FeB6 A/Aw-J-Spnb4qv-J/J
001203   C3FeB6F1/J A/Aw-J
001272   C3H/HeSnJ-Ahvy/J
000099   C3HeB/FeJ-Avy/J
000338   C57BL/6J Aw-J-EdaTa-6J/J
000258   C57BL/6J-Ai/a/J
000774   C57BL/6J-Asy/a/J
000569   C57BL/6J-Aw-J-EdaTa +/+ ArTfm/J
000051   C57BL/6J-Aw-J/J
000055   C57BL/6J-at-33J/J
000070   C57BL/6J-atd/J
002468   KK.Cg-Ay/J
000262   LS/LeJ
000283   LT.CAST-A/J
001759   STOCK A Tyrc Sha/J
001427   STOCK Aw us/J
View Strains carrying other alleles of a     (81 strains)

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms
      assigned by genotype

Edaraddcr/Edaraddcr

        B6C3Fe a/a-Edaraddcr/J
  • behavior/neurological phenotype
  • abnormal involuntary movement (MGI Ref ID J:5870)
    • mutants twirl in the air when picked up by their tails; variable penetrance
  • homeostasis/metabolism phenotype
  • *normal* homeostasis/metabolism phenotype (MGI Ref ID J:29151)
    • no aberrant bleeding time after tail vein nick
    • abnormal lipid level (MGI Ref ID J:5870)
      • sulfatides are increased in P21 mutant brains, however levels are normal at 17 months of age
      • at 17 months of age, cerebroside levels are higher and cholesterol esters are found in brains
  • nervous system phenotype
  • abnormal brain morphology (MGI Ref ID J:5870)
    • 33% have grossly malformed brains at P21
    • brains contain increased levels of sulfatides at P21 but not at older ages and increased cerebroside and cholesterl ester levels in older mice
    • abnormal cerebellum morphology (MGI Ref ID J:5870)
      • abnormalities of the cerebellum include abnormal shape and cavitation
      • many mutants exhibit an abnormal lateral fissure parallel to the median cerebral fissure
      • abnormal cerebellar cortex morphology (MGI Ref ID J:5870)
        • all layers of the cerebellar cortex are disorganized
        • Purkinje cell degeneration (MGI Ref ID J:5870)
          • two mutants show pyknosis and loss of some Purkinje cells
      • small cerebellum (MGI Ref ID J:5870)
  • demyelination (MGI Ref ID J:5870)
    • in myelinated areas, especially in the cerebellum, holes are present which seem to be the result of swollen myelin sheaths and the disarranged myelin appears in patches, not diffusely
    • presence of cholesterol esters in the brain indicates demyelination
  • reproductive system phenotype
  • reduced fertility (MGI Ref ID J:5870)
  • respiratory system phenotype
  • abnormal respiratory mucosa morphology (MGI Ref ID J:119848)
    • at P7 and P14, mice lack submucosal glands

The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.

Edaraddcr/Edaraddcr

        involves: C57BL/6 * C3H
  • lethality-postnatal
  • postnatal lethality (MGI Ref ID J:13040)
    • 40% die before 10 days of age
    • only approximately 22-24% of homozygotes survived to wean age
    • supplementation of the mothers copper intake during pregnancy and lactation can improve viability so that 50% of homozygotes survive to wean age
    • while only 22 to 24% of homozygotes survive to 30 days of age, supplementing the dam's diet with high levels of copper increased survival at 30 days of age to 50%
  • life span-post-weaning/aging
  • premature death (MGI Ref ID J:13040)
    • mortality increases slightly up to the time of weaning and is very high the week after weaning
  • growth/size phenotype
  • decreased body weight (MGI Ref ID J:13040)
    • already at birth, mutants are 5% lighter than controls; 20-30% lighter at 3 weeks
  • postnatal growth retardation (MGI Ref ID J:13040)
    • slower growth
  • craniofacial phenotype
  • abnormal outer ear morphology (MGI Ref ID J:13040)
    • at about 10-15 days of age, the ears are folded in a peculiar way and the pinnae appear to be drawn up toward the mid-dorsal line
  • abnormal tooth morphology (MGI Ref ID J:12999)
    • abnormal enamel morphology (MGI Ref ID J:12999)
      • incisors are more widely covered with enamel, even if normal sized
    • abnormal incisor morphology (MGI Ref ID J:12999)
      • incisors may be smaller and sometimes an incisor is lost
    • abnormal molar crown morphology (MGI Ref ID J:12999)
      • cusps of all molars are reduced but the pattern is different from that seen in homozygous Lrp6Cd mutants
    • decreased molar number (MGI Ref ID J:12999)
      • third molars are sometimes absent
    • small molars (MGI Ref ID J:12999)
      • reduction of molars tends to be more extreme in the first than in the second and third molars
  • limbs/digits/tail phenotype
  • kinked tail (MGI Ref ID J:64273)
    • tail has sharp flexures near the tip
    • young mice (5-14 days) have kinks or undulations along more than half the length of the tail; as mice age, the kinks straighten out and are confined to the extreme tip
  • skin/coat/nails phenotype
  • abnormal coat/ hair morphology (MGI Ref ID J:13040)
    • absence of 2 or 3 of the 5 sensory hairs on each side of the face; lack the hair situated behind the eye, one of the two near the angle of the jaw, and one of the two above the eye
    • scanning electron micrographs show that hairs from adults have alternate narrowing and thickening (monilethrix), twisting along the axis (pili torti), or rough nodular shafts with frayed ends (trichorrhexis nodosa)
    • abnormal coat/hair pigmentation (MGI Ref ID J:13040)
      • color pattern of agouti is modified; the back is blacker, the flanks are yellower than normal
      • increased maternal dietary copper during pregnancy and lactation can darken the coat color of homozygous pups assessed at 6 days of age
    • abnormal hair follicle development (MGI Ref ID J:13040)
      • formation of new hair follicles is suppressed between E12.5 and E17, and again from the time of birth onwards
      • the growth rate of those follicles that do form is slowed
      • first period of follicle suppression accounts for the absence of guard hairs and the second period for the absence of zigzags
      • sensory hair follicles are sometimes poorly developed; the first stage of the development of the post-orbital sinus follicle is normal, however after E12.5, further development is inhibited and the follicle regresses
      • the diminished number of hair follicles in homozygous 6 day old pups is increased toward normal numbers by feeding the mother a high copper diet
      • underdeveloped hair follicles (MGI Ref ID J:5568)
        • at 6 days of age the number of hair follicles is greatly reduced and there are few hairs emerging from the skin surface, but providing the mother with supplemental dietary copper during pregnancy and lactation can increase the number of hair follicles
    • abnormal hair growth (MGI Ref ID J:13040)
      • delayed hair appearance (MGI Ref ID J:13040)
        • growth of hair follicles is slower and the appearance of hair rudiments is delayed by about 2 days
        • sinus follicles that do form, grow more slowly and their hairs erupt later than in wild-type
      • focal hair loss (MGI Ref ID J:13040)
        • no hair on tail or behind ears
      • loss of cilia (MGI Ref ID J:13040)
        • reduced number of eyelashes, with both the longest and shortest lashes absent
      • short hair (MGI Ref ID J:13040)
        • hairs on the pinna are shorter and thinner
      • sparse hair (MGI Ref ID J:13040)
        • hair density is reduced
    • abnormal hair texture (MGI Ref ID J:13040)
      • coat is thin and has an abnormal texture which makes it look ungroomed
    • abnormal hair types (MGI Ref ID J:13040)
      • mutants contain only one type of hair resembling an abnormal awl; the number of rows of air-cells is not constant throughout the length of each hair and the diameter of the hair varies, regions with two rows of cells alternate with narrower regions having only one row and with broader regions having three rows
      • absent guard hair (MGI Ref ID J:13040)
        • lack guard hairs in the adult coat
      • absent zigzag hairs (MGI Ref ID J:13040)
        • lack zigzag hairs in the adult coat
    • decreased hair follicle number (MGI Ref ID J:13040)
      • the supra-orbital tubercle contains only one follicle instead of two as in wild-type at E13.5
  • abnormal skin morphology (MGI Ref ID J:13040)
    • no tail rings
    • abnormal epidermal layer morphology (MGI Ref ID J:5568)
      • at 6 days of age the skin has a smooth surface, but providing supplemental dietary copper to the mother during pregnancy and lactation can result in a rough epipermal surface in 6 day old pups
    • thin dermal layer (MGI Ref ID J:13040)
  • abnormal skin pigmentation (MGI Ref ID J:13040)
    • delay in skin pigmentation due to delayed hair formation (by about 2 days)
  • pallor (MGI Ref ID J:5680)
    • the pallid and smooth skin of homozygotes can be darkened and made more normal in texture by feeding the mother a high copper diet
  • thin skin (MGI Ref ID J:13040)
    • thin skin is seen soon after birth and persists throughout life
    • the skin is thinner than normal and this can be diminished by giving the mother supplemental dietary copper during pregnancy and lactation
  • pigmentation phenotype
  • abnormal coat/hair pigmentation (MGI Ref ID J:13040)
    • color pattern of agouti is modified; the back is blacker, the flanks are yellower than normal
    • increased maternal dietary copper during pregnancy and lactation can darken the coat color of homozygous pups assessed at 6 days of age
  • abnormal skin pigmentation (MGI Ref ID J:13040)
    • delay in skin pigmentation due to delayed hair formation (by about 2 days)
  • respiratory system phenotype
  • abnormal respiration (MGI Ref ID J:64273)
    • frequently exhibit respiratory disorders
    • respiratory disorder is characterized by snuffling and is caused by an accumulation of hairs from the body in the nasal passages
  • vision/eye phenotype
  • abnormal cornea morphology (MGI Ref ID J:13040)
    • develop corneal ulceration in late life
    • corneal opacity (MGI Ref ID J:13040)
      • later in life, the cornea becomes opaque
  • abnormal eyelid morphology (MGI Ref ID J:64273)
    • eyelids are abnormal leading to corneal ulceration in late life
    • absent meibomian glands (MGI Ref ID J:13040)
    • loss of cilia (MGI Ref ID J:13040)
      • reduced number of eyelashes, with both the longest and shortest lashes absent
    • narrow eye opening (MGI Ref ID J:13040)
      • the aperture made by the eyelids is smaller
  • hearing/vestibular/ear phenotype
  • abnormal outer ear morphology (MGI Ref ID J:13040)
    • at about 10-15 days of age, the ears are folded in a peculiar way and the pinnae appear to be drawn up toward the mid-dorsal line
  • behavior/neurological phenotype
  • abnormal maternal nurturing (MGI Ref ID J:13040)
    • mothering ability is somewhat reduced
  • reproductive system phenotype
  • decreased litter size (MGI Ref ID J:13040)
    • litter size is slightly smaller
  • reduced female fertility (MGI Ref ID J:13040)
  • endocrine/exocrine gland phenotype
  • absent meibomian glands (MGI Ref ID J:13040)
  • hematopoietic system phenotype
  • anemia (MGI Ref ID J:5680)
    • anemia with low hemoglobin levels, low red blood cell number, and low packed cell volume is found at 21 days of age
  • nervous system phenotype
  • abnormal myelination (MGI Ref ID J:5680)
    • at 60 days of age homozygotes have less myelination
    • demyelination (MGI Ref ID J:5680)
      • demyelination is found in 4 of 5 homozygotes over 1 year of age, and at 17 months of age there is focal degeneration in cerebellar white matter

Edaraddcr/Edaraddcr

        involves: C57BL/6J
  • skin/coat/nails phenotype
  • abnormal hair growth (MGI Ref ID J:5774)
    • tail grafts from embryonic day 15 tails shows that the site of action of crinkled is in the epidermis not the dermis
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Edaraddcr related

Apoptosis Research
Death Receptors

Dermatology Research
Skin and Hair Texture Defects

Mouse/Human Gene Homologs
hypohidrotic ectodermal dysplasia

Genes & Alleles

Gene & Allele Information

 
Allele Symbol Edaraddcr
Allele Name crinkled
Allele Type Chemically induced (other)
Common Name(s) cr;
Gene Symbol and Name Edaradd, EDAR (ectodysplasin-A receptor)-associated death domain
Chromosome 13
Gene Common Name(s) 1810032E07Rik; 5830469M23Rik; ED3; EDA3; RGD1564010; RIKEN cDNA 1810032E07 gene; RIKEN cDNA 5830469M23 gene; cr; crinkled;
General Note Appeared in the progeny of a male treated with nitrogen mustard. Homozygotes have coats that are thinner than normal and contain only one type of hair resembling an abnormal awl, rather than the four types of hair of the normal coat. There is a bald patch behind the ears, bald tail, kinks at the tail tip, absence of Meibomian glands, a respiratory disorder, modification of the agouti pattern (J:13040), abnormal molars and incisors (J:12999, J:5018, J:5139), and probably abnormalities of many exocrine glands (J:5193). Viability and breeding performance are somewhat reduced (J:13040). Myelin abnormalities have been described in the brains of old crinkled mice (J:5870). Hair follicle initiation is restricted to the period between 17 days of gestation and birth, rather than extending from 14 days of gestation to several days after birth as in normal mice (J:13040). Heterozygotes have normal coats, but many have slight abnormalities of the upper molars (J:5018). The site of gene action inskin of cr/cr mice has been shown, by means of dermal-epidermal recombination grafts of embryonic skin, to be in the epidermis (J:5774). The level of copper in liver is low in young cr/cr mice and the level of activity in liver of the copper-containing enzyme superoxide dismutase (SOD) is also low in both young and adult mice (J:6230). Copper supplementation of the diet of mothers during pregnancy and lactation increases survival of homozygotes, improves coat development, and raises SOD activityand liver copper concentration to normal (J:5568, J:6230).
Molecular Note PCR analysis of genomic DNA showed that the entire coding region of the gene is deleted. Northern analysis failed to detect transcript in skin RNA from homozygous mutant animals at E18.5. [MGI Ref ID J:73357] [MGI Ref ID J:75381]
 
Allele Symbol a
Allele Name nonagouti
Allele Type Spontaneous

Genotyping

Genotyping Information

This strain will not have a genotyping protocol or one is not currently available.

Helpful Links

Genotyping resources and troubleshooting

References

References

Additional References

Headon DJ; Emmal SA; Ferguson BM; Tucker AS; Justice MJ; Sharpe PT; Zonana J; Overbeek PA. 2001. Gene defect in ectodermal dysplasia implicates a death domain adapter in development. Nature 414(6866):913-6. [PubMed: 11780064]  [MGI Ref ID J:73357]

Edaraddcr related

Falconer DS. 1949. cr - crinkled Mouse News Lett 1S:4.  [MGI Ref ID J:64273]

Falconer DS; Fraser AS; King JWB. 1951. The genetics and development of "crinkled", a new mutant in the house mouse. J Genet 50:324-344.  [MGI Ref ID J:13040]

Gruneberg H. 1965. Genes and genotypes affecting the teeth of the mouse. J Embryol Exp Morphol 14(2):137-59. [PubMed: 5893447]  [MGI Ref ID J:12999]

Gruneberg H. 1971. The glandular aspects of the tabby syndrome in the mouse. J Embryol Exp Morphol 25(1):1-19. [PubMed: 5548211]  [MGI Ref ID J:5193]

Gruneberg H. 1966. The molars of the tabby mouse, and a test of the 'single-active X-chromosome' hypothesis. J Embryol Exp Morphol 15(2):223-44. [PubMed: 5959976]  [MGI Ref ID J:5018]

Headon DJ; Emmal SA; Ferguson BM; Tucker AS; Justice MJ; Sharpe PT; Zonana J; Overbeek PA. 2001. Gene defect in ectodermal dysplasia implicates a death domain adapter in development. Nature 414(6866):913-6. [PubMed: 11780064]  [MGI Ref ID J:73357]

Hurley LS. 1976. Interaction of genes and metals in development. Fed Proc 35(11):2271-5. [PubMed: 133823]  [MGI Ref ID J:5680]

Hurley LS; Bell LT. 1975. Amelioration by copper supplementation of mutant gene effects in the crinkled mouse. Proc Soc Exp Biol Med 149(4):830-4. [PubMed: 1166079]  [MGI Ref ID J:5568]

Keen CL; Hurley LS. 1979. Superoxide dismutase activity in the crinkled mutant mouse: ameliorative effects of dietary copper supplementation. Proc Soc Exp Biol Med 162(1):152-6. [PubMed: 504225]  [MGI Ref ID J:6230]

Langton AK; Herrick SE; Headon DJ. 2008. An extended epidermal response heals cutaneous wounds in the absence of a hair follicle stem cell contribution. J Invest Dermatol 128(5):1311-8. [PubMed: 18037901]  [MGI Ref ID J:135502]

Mayer TC; Miller CK; Green MC. 1977. Site of action of the crinkled (cr) locus in the mouse. Dev Biol 55(2):397-401. [PubMed: 320066]  [MGI Ref ID J:5774]

Mou C; Jackson B; Schneider P; Overbeek PA; Headon DJ. 2006. Generation of the primary hair follicle pattern. Proc Natl Acad Sci U S A 103(24):9075-80. [PubMed: 16769906]  [MGI Ref ID J:111052]

Ohazama A; Courtney JM; Tucker AS; Naito A; Tanaka S; Inoue J; Sharpe PT. 2004. Traf6 is essential for murine tooth cusp morphogenesis. Dev Dyn 229(1):131-5. [PubMed: 14699584]  [MGI Ref ID J:87318]

Rao MS; Jaszczak E; Landis SC. 1994. Innervation of footpads of normal and mutant mice lacking sweat glands. J Comp Neurol 346(4):613-25. [PubMed: 7983247]  [MGI Ref ID J:19910]

Rawlins EL; Hogan BL. 2005. Intercellular growth factor signaling and the development of mouse tracheal submucosal glands. Dev Dyn 233(4):1378-85. [PubMed: 15973734]  [MGI Ref ID J:119848]

Sofaer JA. 1979. Additive effects of the genes tabby and crinkled on tooth size in the mouse. Genet Res 33(2):169-74. [PubMed: 478295]  [MGI Ref ID J:151073]

Sofaer JA. 1969. Aspects of the tabby-crinkled-downless syndrome. I. The development of tabby teeth. J Embryol Exp Morphol 22(2):181-205. [PubMed: 5361554]  [MGI Ref ID J:5138]

Sofaer JA. 1969. Aspects of the tabby-crinkled-downless syndrome. II. Observations on the reaction to changes of genetic background. J Embryol Exp Morphol 22(2):207-27. [PubMed: 5361555]  [MGI Ref ID J:5139]

Sundberg JP (ed.). 1994. . In: Handbook of Mouse Mutations with Skin and Hair Abnormalities: Animal Models and Biomedical Tools. CRC Press, Boca Raton.  [MGI Ref ID J:30359]

Swank RT; Reddington M; Howlett O; Novak EK. 1991. Platelet storage pool deficiency associated with inherited abnormalities of the inner ear in the mouse pigment mutants muted and mocha. Blood 78(8):2036-44. [PubMed: 1912584]  [MGI Ref ID J:29151]

Theriault LL; Dungan DD; Simons S; Keen CL; Hurley LS. 1977. Lipid and myelin abnormalities of brain in the crinkled mouse. Proc Soc Exp Biol Med 155(4):549-53. [PubMed: 896803]  [MGI Ref ID J:5870]

Yan M; Zhang Z; Brady JR; Schilbach S; Fairbrother WJ; Dixit VM. 2002. Identification of a Novel Death Domain-Containing Adaptor Molecule for Ectodysplasin-A Receptor that Is Mutated in crinkled Mice. Curr Biol 12(5):409-13. [PubMed: 11882293]  [MGI Ref ID J:75381]

Health & husbandry

Health & Colony Maintenance Information

Colony Maintenance

Mating SystemOutcross-Intercross         (Female x Male)   01-MAR-06
TJL Breeding Summary: homozyogote x B6C3Fe a/a F1 then obligate heterozygote x heterozygote

Purchasing information

Pricing, Supply Level & Notes, Controls, General Terms & Conditions

Pricing

Pricing for USA, Canada and Mexico shipping destinations View International pricing
Price (US dollars $)
Cryorecovery Fee $1900.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Additional Supply Details

Pricing for International shipping destinations View USA Canada and Mexico pricing
Price (US dollars $)
Cryorecovery Fee $2470.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Additional Supply Details

Supply Details

Standard SupplyCryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information.
Supply Notes
  • Cryorecovery - Standard.
    We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. The total number of animals provided, their gender and genotype will vary. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 13 and 16 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
    Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

  • This strain is included in the Mouse Mutant Resource collection.
  • Genomic DNA is available for this strain from the Mouse DNA Resource.

Control Information

  Control
   +/? from the colony
 
  Considerations for Choosing Controls
  USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains.
  International - Control Pricing Information for Genetically Engineered Mutant Strains.

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.


See Terms of Use tab for General Terms and Conditions


The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
Ordering and Purchasing Information

      Purchasing Information
      JAX® Mice Orders
      Surgical Services

Contact Information
Orders & Technical Support
Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
Technical Support Email Form

Terms of Use

Terms of Use


General Terms and Conditions


Contact information

General inquiries

Contracts Administration

phone:207-288-6470
fax:207-288-6655

JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. In purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


(3.12)