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Strain Name:

B6C3Fe a/a-Edaraddcr/J

Stock Number:

000207

Availability:

Repository-Cryopreserved

Price and Supply Information

General Terms and Conditions

Former Name      B6C3Fe-a/a-Edaraddcr    (Changed: 15-DEC-04 )
Genes & Alleles   Edaradd;   Edaraddcr;   a;

Product Information

Strain Details

Type JAX® GEMM® Strain - Mutant Stock
Additional information on JAX® GEMM® Strains.
Mating SystemOutcross-Intercross         (Female x Male)
TJL Breeding Summary: homozyogote x B6C3Fe a/a F1 then obligate heterozygote x heterozygote
Specieslaboratory mouse
GenerationN34p

Appearance
black
Related Genotype: a/a Edaraddcr/+ or a/a +/?

black, aberrent coat and teeth
Related Genotype: a/a Edaraddcr/Edaraddcr

Mammalian Phenotype Terms assigned by genotype

Edaraddcr/Edaraddcr

        B6C3Fe a/a-Edaraddcr/J
  • behavior/neurological phenotype
  • abnormal involuntary movement (MGI Ref ID J:5870)
    • mutants twirl in the air when picked up by their tails; variable penetrance
  • homeostasis/metabolism phenotype
  • *normal* homeostasis/metabolism phenotype (MGI Ref ID J:29151)
    • no aberrant bleeding time after tail vein nick
    • abnormal lipid level (MGI Ref ID J:5870)
      • sulfatides are increased in P21 mutant brains, however levels are normal at 17 months of age
      • at 17 months of age, cerebroside levels are higher and cholesterol esters are found in brains
  • nervous system phenotype
  • abnormal brain morphology (MGI Ref ID J:5870)
    • 33% have grossly malformed brains at P21
    • brains contain increased levels of sulfatides at P21 but not at older ages and increased cerebroside and cholesterl ester levels in older mice
    • abnormal cerebellum morphology (MGI Ref ID J:5870)
      • abnormalities of the cerebellum include abnormal shape and cavitation
      • many mutants exhibit an abnormal lateral fissure parallel to the median cerebral fissure
      • abnormal cerebellar cortex morphology (MGI Ref ID J:5870)
        • all layers of the cerebellar cortex are disorganized
        • Purkinje cell degeneration (MGI Ref ID J:5870)
          • two mutants show pyknosis and loss of some Purkinje cells
      • small cerebellum (MGI Ref ID J:5870)
  • demyelination (MGI Ref ID J:5870)
    • in myelinated areas, especially in the cerebellum, holes are present which seem to be the result of swollen myelin sheaths and the disarranged myelin appears in patches, not diffusely
    • presence of cholesterol esters in the brain indicates demyelination
  • reproductive system phenotype
  • reduced fertility (MGI Ref ID J:5870)

The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.

Edaraddcr/Edaraddcr

        Background Not Specified
  • lethality-postnatal
  • postnatal lethality (MGI Ref ID J:13040)
    • 40% die before 10 days of age
  • life span-post-weaning/aging
  • premature death (MGI Ref ID J:13040)
    • mortality increases slightly up to the time of weaning and is very high the week after weaning
  • growth/size phenotype
  • decreased body weight (MGI Ref ID J:13040)
    • already at birth, mutants are 5% lighter than controls; 20-30% lighter at 3 weeks
  • postnatal growth retardation (MGI Ref ID J:13040)
    • slower growth
  • craniofacial phenotype
  • abnormal outer ear morphology (MGI Ref ID J:13040)
    • at about 10-15 days of age, the ears are folded in a peculiar way and the pinnae appear to be drawn up toward the mid-dorsal line
  • abnormal tooth morphology (MGI Ref ID J:12999)
    • abnormal enamel morphology (MGI Ref ID J:12999)
      • incisors are more widely covered with enamel, even if normal sized
    • abnormal incisor morphology (MGI Ref ID J:12999)
      • incisors may be smaller and sometimes an incisor is lost
    • abnormal molar crown morphology (MGI Ref ID J:12999)
      • cusps of all molars are reduced but the pattern is different from that seen in homozygous Lrp6Cd mutants
    • decreased molar number (MGI Ref ID J:12999)
      • third molars are sometimes absent
    • small molars (MGI Ref ID J:12999)
      • reduction of molars tends to be more extreme in the first than in the second and third molars
  • limbs/digits/tail phenotype
  • kinked tail (MGI Ref ID J:64273)
    • tail has sharp flexures near the tip
    • young mice (5-14 days) have kinks or undulations along more than half the length of the tail; as mice age, the kinks straighten out and are confined to the extreme tip
  • skin/coat/nails phenotype
  • abnormal coat/ hair morphology (MGI Ref ID J:13040)
    • absence of 2 or 3 of the 5 sensory hairs on each side of the face; lack the hair situated behind the eye, one of the two near the angle of the jaw, and one of the two above the eye
    • abnormal coat color (MGI Ref ID J:13040)
      • color pattern of agouti is modified; the back is blacker, the flanks are yellower than normal
    • abnormal hair follicle development (MGI Ref ID J:13040)
      • formation of new hair follicles is suppressed between E12.5 and E17, and again from the time of birth onwards
      • the growth rate of those follicles that do form is slowed
      • first period of follicle suppression accounts for the absence of guard hairs and the second period for the absence of zigzags
      • sensory hair follicles are sometimes poorly developed; the first stage of the development of the post-orbital sinus follicle is normal, however after E12.5, further development is inhibited and the follicle regresses
    • abnormal hair growth (MGI Ref ID J:13040)
      • delayed hair appearance (MGI Ref ID J:13040)
        • growth of hair follicles is slower and the appearance of hair rudiments is delayed by about 2 days
        • sinus follicles that do form, grow more slowly and their hairs erupt later than in wild type
      • localized bare skin (MGI Ref ID J:13040)
        • no hair on tail or behind ears
      • loss of cilia (MGI Ref ID J:13040)
        • reduced number of eyelashes, with both the longest and shortest lashes absent
      • short hair (MGI Ref ID J:13040)
        • hairs on the pinna are shorter and thinner
      • sparse hair (MGI Ref ID J:13040)
        • hair density is reduced
    • abnormal hair texture (MGI Ref ID J:13040)
      • coat is thin and has an abnormal texture which makes it look ungroomed
    • abnormal hair types (MGI Ref ID J:13040)
      • mutants contain only one type of hair resembling an abnormal awl; the number of rows of air-cells is not constant throughout the length of each hair and the diameter of the hair varies, regions with two rows of cells alternate with narrower regions having only one row and with broader regions having three rows
      • absent guard hair (MGI Ref ID J:13040)
        • lack guard hairs in the adult coat
      • absent zigzag hairs (MGI Ref ID J:13040)
        • lack zigzag hairs in the adult coat
    • decreased hair follicle number (MGI Ref ID J:13040)
      • the supra-orbital tubercle contains only one follicle instead of two as in wild type at E13.5
  • abnormal skin morphology (MGI Ref ID J:13040)
    • no tail rings
    • absent meibomian glands (MGI Ref ID J:13040)
    • thin dermal layer (MGI Ref ID J:13040)
  • abnormal skin pigmentation (MGI Ref ID J:13040)
    • delay in skin pigmentation due to delayed hair formation (by about 2 days)
  • thin skin (MGI Ref ID J:13040)
    • thin skin is seen soon after birth and persists throughout life
  • pigmentation phenotype
  • abnormal coat color (MGI Ref ID J:13040)
    • color pattern of agouti is modified; the back is blacker, the flanks are yellower than normal
  • abnormal skin pigmentation (MGI Ref ID J:13040)
    • delay in skin pigmentation due to delayed hair formation (by about 2 days)
  • respiratory system phenotype
  • abnormal respiration (MGI Ref ID J:64273)
    • frequently exhibit respiratory disorders
    • respiratory disorder is characterized by snuffling and is caused by an accumulation of hairs from the body in the nasal passages
  • vision/eye phenotype
  • abnormal cornea morphology (MGI Ref ID J:13040)
    • develop corneal ulceration in late life
    • corneal opacity (MGI Ref ID J:13040)
      • later in life, the cornea becomes opaque
  • abnormal eyelid morphology (MGI Ref ID J:64273)
    • eyelids are abnormal leading to corneal ulceration in late life
    • absent meibomian glands (MGI Ref ID J:13040)
    • narrow eye opening (MGI Ref ID J:13040)
      • the aperture made by the eyelids is smaller
  • hearing/vestibular/ear phenotype
  • abnormal outer ear morphology (MGI Ref ID J:13040)
    • at about 10-15 days of age, the ears are folded in a peculiar way and the pinnae appear to be drawn up toward the mid-dorsal line
  • behavior/neurological phenotype
  • abnormal maternal nurturing (MGI Ref ID J:13040)
    • mothering ability is somewhat reduced
  • reproductive system phenotype
  • decreased litter size (MGI Ref ID J:13040)
    • litter size is slightly smaller
  • reduced female fertility (MGI Ref ID J:13040)
  • endocrine/exocrine gland phenotype
  • absent meibomian glands (MGI Ref ID J:13040)

Gene & Allele Details

Allele Symbol Edaraddcr
Allele Name crinkled
Common Name(s) cr;
Gene Symbol and Name Edaradd, EDAR (ectodysplasin-A receptor)-associated death domain
Chromosome 13
Gene Common Name(s) 1810032E07Rik; 5830469M23Rik; ED3; EDA3; RGD1564010; RIKEN cDNA 1810032E07 gene; RIKEN cDNA 5830469M23 gene; cr; crinkled;
General Note Appeared in the progeny of a male treated with nitrogen mustard. Homozygotes have coats that are thinner than normal and contain only one type of hair resembling an abnormal awl, rather than the four types of hair of the normal coat. There is a bald patch behind the ears, bald tail, kinks at the tail tip, absence of Meibomian glands, a respiratory disorder, modification of the agouti pattern (J:13040), abnormal molars and incisors (J:12999, J:5018, J:5139), and probably abnormalities of many exocrine glands (J:5193). Viability and breeding performance are somewhat reduced (J:13040). Myelin abnormalities have been described in the brains of old crinkled mice (J:5870). Hair follicle initiation is restricted to the period between 17 days of gestation and birth, rather than extending from 14 days of gestation to several days after birth as in normal mice (J:13040). Heterozygotes have normal coats, but many have slight abnormalities of the upper molars (J:5018). The site of gene action inskin of cr/cr mice has been shown, by means of dermal-epidermal recombination grafts of embryonic skin, to be in the epidermis (J:5774). The level of copper in liver is low in young cr/cr mice and the level of activity in liver of the copper-containing enzyme superoxide dismutase (SOD) is also low in both young and adult mice (J:6230). Copper supplementation of the diet of mothers during pregnancy and lactation increases survival of homozygotes, improves coat development, and raises SOD activityand liver copper concentration to normal (J:5568, J:6230).
Molecular Note PCR analysis of genomic DNA showed that the entire coding region of the gene is deleted. Northern analysis failed to detect transcript in skin RNA from homozygous mutant animals at E18.5. [MGI Ref ID J:73357] [MGI Ref ID J:75381]
 
Allele Symbol a
Allele Name nonagouti

Control Information

  Allele   Control
 Edaraddcr  +/? from the colony
 
  Considerations for Choosing Controls
  Control Pricing Information for JAX® GEMM® Strains

Related Strains

Strains carrying   a allele
003879   B10;TFLe-a/a T tf/+ tf/J
001538   B6 x B6C3Sn a/A-T(1;9)27H/J
000916   B6 x B6C3Sn a/A-T(5;12)31H/J
000602   B6 x B6C3Sn a/A-T(8;16)17H/J
000618   B6 x FSB/GnEi a/a Ctslfs/J
000577   B6 x STOCK a Oca2p Hps5ru2 Ednrbs/J
000601   B6 x STOCK a/a T(7;18)50H/J
000592   B6 x STOCK T(2;4)13H a/J
000001   B6.C3 A/a Mgrn1md/J
000785   B6;D2-a Es1e/J
000604   B6C3 a/A-T(10;13)199H +/+ Lystbg-J/J or Lystbg-2J/J
002807   B6C3Fe a/a-Meox2fla/J
000224   B6C3Fe a/a-Scyl1mdf/J
001037   B6C3Fe a/a-Agtpbp1pcd/J
000221   B6C3Fe a/a-Alx4lst-J/J
002062   B6C3Fe a/a-Atp7aMo-8J/J
001756   B6C3Fe a/a-Cacng2stg/J
001815   B6C3Fe a/a-Col1a2oim/J
000231   B6C3Fe a/a-Csf1op/J
000209   B6C3Fe a/a-Dh/J
000211   B6C3Fe a/a-Dstdt-J/J
000210   B6C3Fe a/a-Edardl-J/J
000182   B6C3Fe a/a-Eef1a2wst/J
001278   B6C3Fe a/a-Glra1spd/J
000241   B6C3Fe a/a-Glrbspa/J
002875   B6C3Fe a/a-Hoxd13spdh/J
000304   B6C3Fe a/a-Krt71Ca Scn8amed-J/J
000226   B6C3Fe a/a-Largemyd/J
000636   B6C3Fe a/a-Lmx1adr-J/J
001280   B6C3Fe a/a-Lse/J
001573   B6C3Fe a/a-MitfMi/J
001035   B6C3Fe a/a-Napahyh/J
000181   B6C3Fe a/a-Otogtwt/J
000278   B6C3Fe a/a-Papss2bm Hps1ep Hps6ru/J
000205   B6C3Fe a/a-Papss2bm/J
002078   B6C3Fe a/a-Pcdh15av-2J/J
000246   B6C3Fe a/a-Pitpnavb/J
001430   B6C3Fe a/a-Ptch1mes/J
000506   B6C3Fe a/a-Qkqk/J
000235   B6C3Fe a/a-Relnrl/J
000237   B6C3Fe a/a-Rorasg/J
000290   B6C3Fe a/a-Sox10Dom/J
000230   B6C3Fe a/a-Tcirg1oc/J
003612   B6C3Fe a/a-Trak1hyrt/J
001512   B6C3Fe a/a-Ttnmdm/J
001607   B6C3Fe a/a-Unc5crcm/J
000005   B6C3Fe a/a-Wc/J
000243   B6C3Fe a/a-Wnt1sw/J
000248   B6C3Fe a/a-Xpl/J
001750   B6C3Fe a/a-XsJ/J
000624   B6C3Fe a/a-anx/J
003020   B6C3Fe a/a-dep/J
002018   B6C3Fe a/a-din/J
002339   B6C3Fe a/a-nma/J
000240   B6C3Fe a/a-soc/J
000063   B6C3Fe a/a-sy/J
001055   B6C3Fe a/a-tip/J
000245   B6C3Fe a/a-tn/J
000296   B6C3Fe-a/a Hoxa13Hd Mcoln3Va-J/J
000019   B6C3Fe-a/a-Itpr1opt/J
001022   B6C3FeF1/J a/a
000971   B6EiC3 a/A-Och/J
000551   B6EiC3 a/A-Tbx15de-H/J
006450   B6EiC3 a/A-Vss/J
000557   B6EiC3-+ a/LnpUl A/J
000503   B6EiC3Sn a/A-Gy/J
001811   B6EiC3Sn a/A-Otcspf-ash/J
002343   B6EiC3Sn a/A-Otcspf/J
000391   B6EiC3Sn a/A-Pax6Sey-Dey/J
001924   B6EiC3Sn a/A-Ts(1716)65Dn
001923   B6EiC3Sn a/A-Ts(417)2Lws Tim/J
000225   C3FeLe.B6 a/a-Ptpn6me/J
000198   C3FeLe.B6-a/J
000291   C3FeLe.Cg-a/a Hm KitlSl Krt71Ca-J/J
001886   C3HeB/FeJLe a/a-gnd/J
000584   C57BL/6J-+ T(1;2)5Ca/a +/J
000284   CWD/LeJ
000670   DBA/1J
000671   DBA/2J
001057   HPT/LeJ
000260   JGBF/LeJ
000265   MY/HuLeJ
000308   SSL/LeJ
000994   STOCK a Myo5ad Mregdsu/J
000064   STOCK a Tyrp1b Sisi/J
002238   STOCK a Tyrp1b shmy/J
001433   STOCK a skt/J
000579   STOCK a tp/J
000319   STOCK a us/J
002648   STOCK a/a Cln6nclf/J
000317   STOCK a/a Egfrwa2/J
000302   STOCK a/a MitfMi-wh +/+ Itpr1opt/J
000286   STOCK a/a Myo5ad fd/+ +/J
000206   STOCK a/a Tyrc-h/J
001432   STOCK a/a Tyrp1b sks/Tyrp1b +/J
000281   STOCK a/a ma ft/ma ft/J
000312   STOCK stb + a/+ Fignfi a/J
000596   STOCK T(2;11)30H/+ x AEJ-a Gdf5bp-H/J or A/J-a Gdf5bp-J/J
000970   STOCK T(2;16)28H A/T(2;16)28H a/J
000590   STOCK T(2;4)1Sn a/J
000594   STOCK T(2;8)26H a/T(2;8)26H a Tyrp1+/Tyrp1b/J
000623   TR/DiEiJ
View Strains carrying   a     (102 strains)

Strains carrying other alleles of Edaradd
004184   STOCK Tg(Wap-HRAS)69Lln Chr YSJL-Edaraddcr-3J/J
View Strains carrying other alleles of Edaradd     (1 strain)

Strains carrying other alleles of a
003301   (C57BL/6J x C3H-Eya1bor)F1/J
000251   AEJ.Cg-ae +/a Gdf5bp-H/J
000202   AEJ/Gn-bd/J
000199   AEJ/GnLeJ
000427   B10.CE-H13b Aw/(30NX)SnJ
000420   B10.LP-H13b Aw/Sn
000477   B10.PA-Pldnpa H3e at/SnJ
000419   B10.UW-H3b we Pax1un at/SnJ
000593   B6 x B6CBCa Aw-J/A-Grid2Lc T(2;6)7Ca MitfMi-wh/J
000502   B6 x B6CBCa Aw-J/A-Myo5aflr Gnb5flr/J
000599   B6 x B6CBCa Aw-J/A-T(5;13)264Ca KitW-v/J
002083   B6 x B6EiC3 a/A-T(7;16)235Dn/J
000507   B6 x B6EiC3 a/A-Otcspf/J
002016   B6(Cg)-Aw-J EdaTa-6J Chr YB6-Sxr/EiJ
000552   B6-Aw-J-EdaTa-6J.Cg-Sxr
001730   B6-Aw-J-EdaTa-6J.Cg-Sxrb Hya-/J
000841   B6-Aw-J.CBy-EdaTa-By/J
001809   B6-Aw-J.Cg-EdaTa-6J +/+ ArTfm/J
000600   B6-Gpi1b x B6CBCa Aw-J/A-T(7;15)9H Gpi1a/J
000769   B6.C/(HZ18)By-at-44J/J
000203   B6.C3-Aiy/a/J
000017   B6.C3Fe-Avy/J
000628   B6.CE-A Amy1b Amy2b/J
005505   B6.Cg-Ay Slc7a11sut/LmLlp
000021   B6.Cg-Ay/J
001572   B6.Cg-am-J/J
100409   B6129PF1/J-Aw-J/Aw
004200   B6;CBACa Aw-J/A-Npr2cn-2J/J
000505   B6C3 Aw-J/A-Mutedmu/J
000604   B6C3 a/A-T(10;13)199H +/+ Lystbg-J/J or Lystbg-2J/J
000065   B6C3Fe a/a-we Pax1un at/J
000314   B6CBACa Aw-J/A-EdaTa/J-XO
000501   B6CBACa Aw-J/A-Aifm1Hq/J
001046   B6CBACa Aw-J/A-Grid2Lc/J
000500   B6CBACa Aw-J/A-Gs/J
002703   B6CBACa Aw-J/A-Hydinhy3/J
000247   B6CBACa Aw-J/A-Kcnj6wv/J
000287   B6CBACa Aw-J/A-Plp1jp EdaTa/J
000515   B6CBACa Aw-J/A-SfnEr/J
000242   B6CBACa Aw-J/A-spc/J
000288   B6CBACa Aw-J/A-we a Mafbkr/J
001201   B6CBACaF1/J-Aw-J/A
001752   B6CBCa Aw-J/A-T(7;15)9H/J
006450   B6EiC3 a/A-Vss/J
000557   B6EiC3-+ a/LnpUl A/J
000504   B6EiC3Sn a/A-Cacnb4lh/J
000553   B6EiC3Sn a/A-Egfrwa2 Wnt3avt/J
001811   B6EiC3Sn a/A-Otcspf-ash/J
002343   B6EiC3Sn a/A-Otcspf/J
001923   B6EiC3Sn a/A-Ts(417)2Lws Tim/J
000200   C3FeB6 A/Aw-J-Ankank/J
000638   C3FeB6 A/Aw-J-Spnb4qv-J/J
001203   C3FeB6F1/J A/Aw-J
001272   C3H/HeSnJ-Ahvy/J
000099   C3HeB/FeJ-Avy/J
000338   C57BL/6J Aw-J-EdaTa-6J/J
000258   C57BL/6J-Ai/a/J
000774   C57BL/6J-Asy/a/J
000569   C57BL/6J-Aw-J-EdaTa +/+ ArTfm/J
000051   C57BL/6J-Aw-J/J
000055   C57BL/6J-at-33J/J
000070   C57BL/6J-atd/J
002468   KK.Cg-Ay/J
000262   LS/LeJ
000283   LT.CAST-A/J
001759   STOCK A Tyrc Sha/J
001427   STOCK Aw us/J
View Strains carrying other alleles of a     (67 strains)

Research Applications

This mouse can be used to support research in many areas including:

Edaraddcr related

Apoptosis Research
Death Receptors

Dermatology Research
Skin and Hair Texture Defects

Mouse/Human Gene Homologs
hypohidrotic ectodermal dysplasia

References

Additional References

Price and Supply Information

Strain Name: B6C3Fe a/a-Edaraddcr/J
Stock Number: 000207

Price Details

IMPORTANT NOTE: Prices are based on shipping destination. The shipping destinations are:

*Pricing for Shipping Destination selected:

        International

Price(s) in US dollars ($)
Cryorecovery Fee $2470.00

Supply Details

Standard SupplyRepository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information.
Supply Notes Cryorecovery - Standard.
The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two males and two females (two pairs) will be provided, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the delivery time to approximately 25 weeks. At least one member of each pair will be of known genotype and will carry the mutation if it is a mutant strain. Please note that pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Price represents a repository maintenance fee, which includes the cost of recovery of the strain from the cryopreservation resource and the periodic replacement of the frozen embryos used for recovery.

Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
One to two pairs will be recovered to establish a Dedicated Supply of mice. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services: Tel: 1-800-422-6423 or 1-207-288-5845; Email: jaxservices@jax.org.
This strain is included in the Mouse Mutant Resource collection.
Genomic DNA is available for this strain from the Mouse DNA Resource.

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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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