Description

Strain Information

Type Inbred Strain; Additional information on Inbred Strains. Species laboratory mouse

Appearance
Agouti
Related Genotype: A/A

Important Note
This strain is segregating for Ltap^Lp.

Control Information

	Control
	Wild-type from the colony
Considerations for Choosing Controls

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms

      assigned by genotype

Vangl2^Lp/Vangl2⁺

        LPT/LeJ

• hearing/vestibular/ear phenotype
• *normal* hearing/vestibular/ear phenotype (MGI Ref ID J:100861)
  • normal stereocilia orientation at E18.5 and in inner ears cultured from E14.5 for 6 days
• limbs/digits/tail phenotype
• kinked tail (MGI Ref ID J:108512)
  • tails are kinked or looped
• behavior/neurological phenotype
• abnormal head movements (MGI Ref ID J:5888)
  • unlike mice descended from KF Stein's albino stock, head wobble is seen
• nervous system phenotype
• abnormal brain ventricle/choroid plexus morphology (MGI Ref ID J:5888)
  • distortions in the septal area
• abnormal lateral ventricle morphology (MGI Ref ID J:5888)
  • usually bilaterally enlarged and distorted although the abnormality may be unilateral
• enlarged lateral ventricles (MGI Ref ID J:5888)
• enlarged third ventricle (MGI Ref ID J:5888)
  • occasionally slightly enlarged
• abnormal hippocampus morphology (MGI Ref ID J:5888)
  • distortions to the overall shape
• delayed neural tube closure (MGI Ref ID J:108512)
  • neural tube remains open at 8- to 9-somite stage

Vangl2^Lp/Vangl2^Lp

        LPT/LeJ

• hearing/vestibular/ear phenotype
• abnormal cochlea morphology (MGI Ref ID J:132697)
  • reduced in size at E18.5
• abnormal organ of Corti (MGI Ref ID J:100861)
  • shorter, wider cochlear ducts
  • inner ears from E15.5 cultured for 6 days fail to grow in length, have misoriented stereocilia, and widened apex
• abnormal orientation of inner hair cell stereociliary bundles (MGI Ref ID J:132697)
  • 70% of inner hair cell bundles are misoriented
• abnormal orientation of outer hair cell stereociliary bundles (MGI Ref ID J:100861)
  • misorientation of stereociliary bundles at E18.5, more severe in the medial region than the base with approximately 95% misoriented in the two outer rows of outer hair cells
  • a significant proportion of bundles in all 3 layers are misoriented
  • vertices are randomly oriented with rotation angles of 40 - 180 degrees
• increased cochlear hair cell number (MGI Ref ID J:100861)
  • increased rows of hair cells within the third of the cochlea nearest the apex
• cardiovascular system phenotype
• abnormal aortic arch morphology (MGI Ref ID J:74156)
  • narrowing or interruption of the left aortic arch in about 40% of mice
• double aortic arch (MGI Ref ID J:74156)
  • in 4 of 6 mice at E13.5 and in 3 of 3 at E18.5
• right aortic arch (MGI Ref ID J:74156)
  • in 2 of 6 at E13.5 with retroesophageal left subclavian artery
• abnormal heart development (MGI Ref ID J:106431)
  • at E12.5, myocardial cells do not appear to extend as far into the septum as in control littermates and myocardial cells fail to extend lamellipodia or filopodia into the endocardial cushion tissue
  • at E13.5, fewer cardiomyocytes extend into the septum, the boundary of the myocardial wall and mesenchymal septum does not follow a smooth curve, and the non-muscularized region of the proximal outlet septum appears larger
  • at E15.5, the outlet septum is malpositioned and not muscularized and the aorta maintains contact with the right ventricle
• abnormal looping morphogenesis (MGI Ref ID J:74156)
  • at E8.5, E9.5, and E10.5, direction of looping is normal but the ventricular loop is rotated clockwise and displaced to the right
  • heart appears displaced in relation to the head but is oriented normally in relation to the forelimb buds
• abnormal semilunar valve morphology (MGI Ref ID J:74156)
  • in some cases (3 of 18) the aortic and pulmonary valves appear as a common valve
• abnormal subclavian artery morphology (MGI Ref ID J:132697)
  • at E14.5, the right subclavian artery is positioned dorsal to the esophagus
  • at E13.5 2 of 6 show right aortic-sided arch with retroesophageal left subclavian artery
• abnormal ventricular septum morphology (MGI Ref ID J:74156)
  • ventricular septal defect
• double outlet right ventricle (MGI Ref ID J:74156)
  • seen in all homozygotes
• embryogenesis phenotype
• *normal* embryogenesis phenotype (MGI Ref ID J:74156)
  • despite abnormalities in aortic arch patterning, neural crest cell migration appears normal, the cranial and dorsal root ganglia are normal in size and position, and no defects in left-right patterning are detected
• abnormal embryogenesis/ development (MGI Ref ID J:108512)
  • at headfold stage, the embryo length to width ratio is reduced similar to that observed in Dvl1^tm1Awb Dvl2^tm1Awb homozygotes
  • reduced cervical flexure
• abnormal notochord morphology (MGI Ref ID J:108512)
  • the notochord is broader
• incomplete embryo turning (MGI Ref ID J:74156)
  • incomplete axial rotation resulting in misalignment of the head and trunk
• nervous system phenotype
• *normal* nervous system phenotype (MGI Ref ID J:74156)
  • despite abnormalities in aortic arch patterning, neural crest cell migration appears normal and the cranial and dorsal root ganglia are normal in size and position
• abnormal orientation of inner hair cell stereociliary bundles (MGI Ref ID J:132697)
  • 70% of inner hair cell bundles are misoriented
• abnormal orientation of outer hair cell stereociliary bundles (MGI Ref ID J:100861)
  • misorientation of stereociliary bundles at E18.5, more severe in the medial region than the base with approximately 95% misoriented in the two outer rows of outer hair cells
  • a significant proportion of bundles in all 3 layers are misoriented
  • vertices are randomly oriented with rotation angles of 40 - 180 degrees
• craniorachischisis (MGI Ref ID J:132697)
• increased cochlear hair cell number (MGI Ref ID J:100861)
  • increased rows of hair cells within the third of the cochlea nearest the apex

The following phenotype information may relate to a genetic background differing from this JAX^® Mice strain.

Vangl2^Lp/Vangl2⁺

        involves: A

• behavior/neurological phenotype
• *normal* behavior/neurological phenotype (MGI Ref ID J:5888)
  • head wobble seen in mice on an LPT/LeJ background is lost in mice descended from KF Stein's albino stock
• abnormal voluntary movement (MGI Ref ID J:133042)
  • reduction if the frequency of forepaw vibrations
• abnormal head movements (MGI Ref ID J:13059)
  • mice display head rocking or wobbling that in some cases tends to choreic activity
  • choreatic movement of the head
• head shaking (MGI Ref ID J:5061)
  • all mice with a marked degree of head shaking also show brain abnormalities
• abnormal locomotor activity (MGI Ref ID J:133042)
  • decrease in the frequency of wire mesh climbing
• decreased vertical activity (MGI Ref ID J:133042)
  • decreased frequency of rearing which involves shaking movements of the forepart of the body
• abnormal tail movements (MGI Ref ID J:133042)
  • absence of tail rattling behavior
• impaired balance (MGI Ref ID J:133042)
  • mice will often fall on their sides when running
• nervous system phenotype
• *normal* nervous system phenotype (MGI Ref ID J:5888)
  • no ventricle abnormalities are detected in mice descended from KF Stein's albino stock unlike mice on an LPT/LeJ background
• abnormal brain ventricle morphology (MGI Ref ID J:5061)
  • large ventriculus impar
  • however, the third and fourth ventricles appear unaffected
• enlarged lateral ventricles (MGI Ref ID J:5061)
  • seen in 7 of 9 mice examined although sometimes only unilaterally
• abnormal corpus callosum morphology (MGI Ref ID J:5061)
  • appears to be reduced in some places
• abnormal dorsal striatum morphology (MGI Ref ID J:5061)
  • slightly deformed at the medial margin and in the septal area with the nucleus lateralis septi clearly malformed
• abnormal hippocampus morphology (MGI Ref ID J:5061)
  • somewhat deformed and caudally displaced
• limbs/digits/tail phenotype
• curly tail (MGI Ref ID J:13059)
  • partial penetrance of loops in the tail
  • variable degree of contortion of the tail ranging from extreme pretzel-like twists to minor angular crooks or curves
• reproductive system phenotype
• abnormal vagina opening (MGI Ref ID J:13059)
  • about one third of females lack a vaginal opening
• skeleton phenotype
• abnormal xiphoid process (MGI Ref ID J:12147)
  • frequent bifurcation of the xiphoid process, extending beyond the cartilaginous tip, is seen
• hearing/vestibular/ear phenotype
• *normal* hearing/vestibular/ear phenotype (MGI Ref ID J:13059)
  • despite abnormal head movements, mice are not deaf
• head shaking (MGI Ref ID J:5061)
  • all mice with a marked degree of head shaking also show brain abnormalities

Vangl2^Lp/Vangl2⁺

        involves: C57BL/6 * CBA/Ca * LPT/LeJ

• nervous system phenotype
• abnormal neural tube closure (MGI Ref ID J:20323)
  • when cultured starting at E8.5 more embryos with open neural tubes are detected suggesting an increase in susceptibility to failure of neural tube closure in stressful conditions
  • however, initiation of closure of the cranial neural tube at the midbrain/forebrain boundary is similar to wild-type
• delayed neural tube closure (MGI Ref ID J:20323)
  • explants of E8.5 embryos show a delay in closure of about 4 - 6 hrs
  • explants of E9.5 and E10.5 embryos show a delay of posterior neuropore closure

Vangl2^Lp/Vangl2^Lp

        involves: A

• lethality-prenatal/perinatal
• perinatal lethality (MGI Ref ID J:13059)
  • while alive in the last few days of gestation, homozygotes do not survive birth
• hearing/vestibular/ear phenotype
• abnormal ear development (MGI Ref ID J:133114)
  • at E15 all elements are present but appear somewhat flattened
  • at E8.5 the otic pit is ill-defined and somewhat misshapen
  • at E9.0 the otic pit is poorly defined, tends to have a deeper slit-like portion, and the cell are flattened, less densely arranged and have microvilli that are disorganized and distorted
  • at E9.5 the otic pit lacks the oval shape seen in control littermates, ventrally the border tends to be flattened and less defined, and the epidermal cells tend to be more irregular in shape with flattened surfaces
• abnormal inner ear morphology (MGI Ref ID J:114748)
  • abnormalities are similar to those in Pax3^Sp homozygotes but with increased severity
• abnormal semicircular canal (MGI Ref ID J:114748)
  • formation is partially or completely suppressed
• dilated endolymphatic sac (MGI Ref ID J:114748)
  • grossly enlarged
• cardiovascular system phenotype
• hemorrhage (MGI Ref ID J:13059)
  • in the last few days before birth the neural tracts are generally fractured across the lumbar region with considerable hemorrhage
  • at E12.5 a hemorrhagic area is present in the flap of metencephalon
  • hemorrhage in the flap of metencephalon is also seen in some (3 of 12) embryos at E10.5 - E11.5
  • into the amniotic cavity in some embryos
• embryogenesis phenotype
• abnormal embryo turning (MGI Ref ID J:12992)
  • abnormal concave flexure of the back suggests that embryos do not complete rotation at E14.5 - E19.5
  • in a study looking at 6 inbred lines, impairment of rotation appears to be more severe in one line (8) than in other lines (16, 44, 55,66, 71)
• abnormal embryonic tissue morphology (MGI Ref ID J:12992)
  • crooks in the back are frequently seen in embryos at E14.5 - E19.5
• abnormal notochord morphology (MGI Ref ID J:12992)
  • at E9.5 the notochord is shorter with an increase in the diameter and extent of the posterior thickened portion compared to control littermates
• abnormal somite development (MGI Ref ID J:12147)
  • at E10 - 11, apparent fusion of some somites is seen associated with torsion of the body
• abnormal somite shape (MGI Ref ID J:12992)
  • at E9.5 posterior somites are often very small and/or irregular in shape
• abnormal somite size (MGI Ref ID J:12992)
  • at E9.5 posterior somites are often very small and/or irregular in shape
• abnormal primitive streak morphology (MGI Ref ID J:12992)
  • at E9 - E9.5, the primitive streak is thicker and longer compared to age-matched control littermates
• abnormal umbilical cord morphology (MGI Ref ID J:12992)
  • at E19 - E20, average cord length is decreased compared to wild-type and heterozygous littermates
• omphalocele (MGI Ref ID J:13059)
  • in a fair number of embryos small hernias are detected
• reduced embryo size (MGI Ref ID J:13059)
  • slightly smaller than wild-type or heterozygous littermates
  • markedly smaller at E14.5 - E19.5
  • reduction in size is not proportional in all parts of the body with the trunk seeming relatively short and the nervous system relatively large for the body
  • in later stages
• skeleton phenotype
• abnormal rib morphology (MGI Ref ID J:12147)
  • at E17 ribs are irregular in shape, asymmetrical and frequently bifurcated
• abnormal rib development (MGI Ref ID J:12147)
  • ossification is somewhat delayed in some embryos and development in all embryos is irregular
  • ribs are less likely to show the normal size taper pattern
• abnormal rib-sternum attachment (MGI Ref ID J:12147)
  • at E13 - 14, ribs fail to contact or just barely contact the mesenchymal sternal bands compared to controls where the ribs appear to be embedded in the sternal bands
  • at E16 connection between the ribs and sternal cartilages is absent instead distorted sternal rudiments extend towards the ribs
  • at E17 the rib tips are more widely separated from the sternum than in control littermates
• abnormal rib-vertebral column attachment (MGI Ref ID J:12147)
  • vertebral parapophyses fail to form and no good articulation between veterbrae and ribs develops
• decreased rib number (MGI Ref ID J:12147)
  • otal number of ribs on either side tends to be decreased with the number of ribs per side frequently different and correlated to the direction of torsion of the body (i.e. animals with a right twist have fewer right ribs)
• rib bifurcation (MGI Ref ID J:12147)
  • bifurcation of about 1/3 of the length of the rib is frequently detected at E17
• rib fusion (MGI Ref ID J:12147)
  • detectable from the earliest appearance of the ribs (around E12) and correlated with bending or torsion of the body
• abnormal sternum morphology (MGI Ref ID J:12147)
  • at E13 - 14, the separation between the right and left sternal rudiements is increased and the rudiments are less dense compared to control littermates
  • at E16 the omosterna is less well developed
  • in newborns the sternum is a single solid asymmetrical bone with variable numbers of lateral extensions and without normal segmentation
  • lateral extensions are usually tipped with cartilage and extend towards the tips of the ribs
• abnormal rib-sternum attachment (MGI Ref ID J:12147)
  • at E13 - 14, ribs fail to contact or just barely contact the mesenchymal sternal bands compared to controls where the ribs appear to be embedded in the sternal bands
  • at E16 connection between the ribs and sternal cartilages is absent instead distorted sternal rudiments extend towards the ribs
  • at E17 the rib tips are more widely separated from the sternum than in control littermates
• abnormal sternebra morphology (MGI Ref ID J:12147)
  • absence of sternebra formation at E16
  • at E17 only rarely is any separation into sternebrae detected
  • in some newborns cases partial segmentation of the sternum is seen but the sternebrae are abnormal in size, shape and number
• abnormal sternum ossification (MGI Ref ID J:12147)
  • the number and size of ossification centers at E17 is normal but the centers are usually asymmetrical and irregular in shape and sometimes fused
• abnormal xiphoid process (MGI Ref ID J:12147)
  • at E16 the xiphoid process appears as a mesenchymal condensation and is not chondrified
  • the cartilaginous bifurcated section is larger than in newborn wild-type littermates
• abnormal vertebrae morphology (MGI Ref ID J:12147)
  • extremely misshapen
• abnormal vertebral arch morphology (MGI Ref ID J:12147)
  • do not form normally
  • parapophyses fail to form
• abnormal vertebral arch development (MGI Ref ID J:133114)
  • neural arches fail to form normally around the open, flat neural tube and are seen to puncture the flattened neural folds
• fusion of vertebral arches (MGI Ref ID J:12147)
  • frequently fuse to form longitudinal bars of variable length and shape
• abnormal vertebral body morphology (MGI Ref ID J:12147)
  • centra are abnormal in size, shape and position and frequently fused
• abnormal vertebral epiphyseal plate morphology (MGI Ref ID J:12147)
  • ossification centers are usually later to appear and more irregular in size and shape
• vertebral fusion (MGI Ref ID J:12147)
  • centra are frequently fused
• fusion of vertebral arches (MGI Ref ID J:12147)
  • frequently fuse to form longitudinal bars of variable length and shape
• nervous system phenotype
• abnormal brain morphology (MGI Ref ID J:133114)
  • in some embryos a large flap-like extension of neural tissue overhangs the face
• abnormal brain development (MGI Ref ID J:12992)
  • at E9.5 the neural anlage in the region of the floor is shorter compared to control littermates
  • the number of mitotic figures is increased in the brain but not in the spinal cord
• abnormal midbrain development (MGI Ref ID J:5550)
  • at E10 and E11 in ventricular cells of the tectum, the mitotic index is increased, generation time is increased, and M, G1 and S (on E11 only) phases of the cell cycle are prolonged
• abnormal forebrain morphology (MGI Ref ID J:133114)
  • at E10 the lumen is collapsed
• abnormal cerebrum morphology (MGI Ref ID J:12992)
  • in some cases the cerebral hemispheres are collapsed at E14.5 - E19.5
• abnormal hindbrain morphology (MGI Ref ID J:5544)
  • at E10, the ventral midline groove is shallower and cells of the groove are less densely covered with microvilli and bulbous processes
  • at E11 the cells are flattened, lack microvilli and have less prominent bulbous processes
  • at E12 - E14, flattened cells with apparently everted edges and deep depressions spanning multiple cells are present in lateral regions
• abnormal metencephalon morphology (MGI Ref ID J:12992)
  • at E10.5, the roof of the metencephalon appears stretched and some cells have pulled apart
• abnormal midbrain morphology (MGI Ref ID J:133114)
  • at E10, mesencephalic tissue protrudes creating a median dorsal extension
  • at E10 mesencephalon cells lack microvilli but retain a fairly normal cilium
  • at E12 - E14, flattened cells with apparently everted edges and deep depressions spanning multiple cells are present in lateral regions
• abnormal neural tube morphology/development (MGI Ref ID J:12992)
  • at E10.5 - E12.5, cell density in portions of the mantle layer of the hindbrain and cord appears to be reduced
• craniorachischisis (MGI Ref ID J:13059)
  • at E10 the neural tissue fails to form a tube and is instead a herniated cranial mass with two broad tracts separated by a narrow groove down the back
  • in the last few days before birth the neural tracts are generally fractured across the lumbar region
  • at E14.5 - E19.5, neural tissue from the posterior border of the metencephalon back is a flat plate with a deep median groove
  • in some embryos flaps of more posterior tissue overlie the diencephalon and sometimes the cerebral hemispheres
  • extends from the midbrain to varying levels of the tail
• digestive/alimentary phenotype
• abnormal digestive system development (MGI Ref ID J:12992)
  • at E9.5 the gut is shorter compared to control littermates
• growth/size phenotype
• abnormal body wall morphology (MGI Ref ID J:12992)
  • at E14.5 - E19.5, hernias in which the liver and intestines are found outside the body wall are seen in one line (8) while 5 other inbred lines of this allele lack hernias (16, 44, 55,66, 71)
• abnormal ventral body wall (MGI Ref ID J:13059)
  • in 2 embryos complete failure of ventral closure is seen with the heart, lungs, liver, and intestines exposed
• omphalocele (MGI Ref ID J:13059)
  • in a fair number of embryos small hernias are detected
• reduced embryo size (MGI Ref ID J:13059)
  • slightly smaller than wild-type or heterozygous littermates
  • markedly smaller at E14.5 - E19.5
  • reduction in size is not proportional in all parts of the body with the trunk seeming relatively short and the nervous system relatively large for the body
  • in later stages

Vangl2^Lp/Vangl2^Lp

        involves: C57BL/6 * CBA/Ca * LPT/LeJ

• nervous system phenotype
• craniorachischisis (MGI Ref ID J:20323)
  • at E9.5 - E10.5, neural tube is open from the hindbrain to the caudal extremity
  • however, initiation of closure of the cranial neural tube at the midbrain/forebrain boundary is similar to wild-type

View Research Applications

Research Applications

This mouse can be used to support research in many areas including:

Vangl2^Lp related

Cardiovascular Research
Heart Abnormalities

Developmental Biology Research
Neural Tube Defects
Skeletal Defects

Internal/Organ Research
Heart Abnormalities

Neurobiology Research
Neural Tube Defects

Genes & Alleles

Gene & Allele Information

Allele Symbol		Vangl2Lp
Allele Name		loop tail
Allele Type		Spontaneous
Common Name(s)		Lp;
Strain of Origin		A
Gene Symbol and Name		Vangl2, vang-like 2 (van gogh, Drosophila)
Chromosome		1
Gene Common Name(s)		C530001F03Rik; KIAA1215; LPP1; LTAP; Lp; Ltap; MGC119403; MGC119404; RIKEN cDNA C530001F03 gene; STB1; STBM; STBM1; loop tail; loop tail associated protein; mKIAA1215; strabismus;
Molecular Note		A transition point mutation that alters a G to an A at position 1391. This is predicted to alter serine 464 to asparagine in the encoded protein. [MGI Ref ID J:70272]

Genotyping

Genotyping Information

This strain will not have a genotyping protocol or one is not currently available.

Helpful Links

Optimizing PCR Protocols

References

References

Additional References

Copp AJ; Checiu I; Henson JN. 1994. Developmental basis of severe neural tube defects in the loop-tail (Lp) mutant mouse: use of microsatellite DNA markers to identify embryonic genotype. Dev Biol 165(1):20-9. [PubMed: 8088438]  [MGI Ref ID J:20323]

Henderson DJ; Conway SJ; Greene ND; Gerrelli D; Murdoch JN; Anderson RH; Copp AJ. 2001. Cardiovascular defects associated with abnormalities in midline development in the Loop-tail mouse mutant. Circ Res 89(1):6-12. [PubMed: 11440971]  [MGI Ref ID J:74156]

Kibar Z; Underhill DA; Canonne-Hergaux F; Gauthier S; Justice MJ; Gros P. 2001. Identification of a new chemically induced allele (lp(m1jus)) at the loop-tail locus: morphology, histology, and genetic mapping. Genomics 72(3):331-7. [PubMed: 11401449]  [MGI Ref ID J:68823]

Murdoch JN; Doudney K; Paternotte C; Copp AJ; Stanier P. 2001. Severe neural tube defects in the loop-tail mouse result from mutation of Lpp1, a novel gene involved in floor plate specification. Hum Mol Genet 10(22):2593-601. [PubMed: 11709546]  [MGI Ref ID J:72911]

Rachel RA; Murdoch JN; Beermann F; Copp AJ; Mason CA. 2000. Retinal axon misrouting at the optic chiasm in mice with neural tube closure defects. Genesis 27(1):32-47. [PubMed: 10862153]  [MGI Ref ID J:62635]

Wilson DB; Wyatt DP. 1994. Analysis of neurulation in a mouse model for neural dysraphism. Exp Neurol 127(1):154-8. [PubMed: 8200433]  [MGI Ref ID J:18787]

Vangl2^Lp related

Abeelen JH van. 1968. Behavioural ontogeny of looptail mice. Anim Behav 16(1):1-4. [PubMed: 5651230]  [MGI Ref ID J:5070]

Abeelen JH van; Raven SM. 1968. Enlarged ventricles in the cerebrum of loop-tail mice. Experientia 24(2):191-2. [PubMed: 4230658]  [MGI Ref ID J:5061]

Carroll EA; Gerrelli D; Gasca S; Berg E; Beier DR; Copp AJ; Klingensmith J. 2003. Cordon-bleu is a conserved gene involved in neural tube formation. Dev Biol 262(1):16-31. [PubMed: 14512015]  [MGI Ref ID J:85744]

Copp AJ; Checiu I; Henson JN. 1994. Developmental basis of severe neural tube defects in the loop-tail (Lp) mutant mouse: use of microsatellite DNA markers to identify embryonic genotype. Dev Biol 165(1):20-9. [PubMed: 8088438]  [MGI Ref ID J:20323]

Deol MS. 1966. Influence of the neural tube on the differentiation of the inner ear in the mammalian embryo. Nature 209(5019):219-20. [PubMed: 5912439]  [MGI Ref ID J:114748]

Garcia-Garcia MJ; Shibata M; Anderson KV. 2008. Chato, a KRAB zinc-finger protein, regulates convergent extension in the mouse embryo. Development 135(18):3053-62. [PubMed: 18701545]  [MGI Ref ID J:139139]

Gerrelli D; Copp AJ. 1997. Failure of neural tube closure in the loop-tail (Lp) mutant mouse: analysis of the embryonic mechanism. Brain Res Dev Brain Res 102(2):217-24. [PubMed: 9352104]  [MGI Ref ID J:43204]

Greene ND; Gerrelli D; Van Straaten HW; Copp AJ. 1998. Abnormalities of floor plate, notochord and somite differentiation in the loop-tail (Lp) mouse: a model of severe neural tube defects. Mech Dev 73(1):59-72. [PubMed: 9545534]  [MGI Ref ID J:47700]

Henderson DJ; Conway SJ; Greene ND; Gerrelli D; Murdoch JN; Anderson RH; Copp AJ. 2001. Cardiovascular defects associated with abnormalities in midline development in the Loop-tail mouse mutant. Circ Res 89(1):6-12. [PubMed: 11440971]  [MGI Ref ID J:74156]

Jones C; Roper VC; Foucher I; Qian D; Banizs B; Petit C; Yoder BK; Chen P. 2008. Ciliary proteins link basal body polarization to planar cell polarity regulation. Nat Genet 40(1):69-77. [PubMed: 18066062]  [MGI Ref ID J:131308]

Kibar Z; Underhill DA; Canonne-Hergaux F; Gauthier S; Justice MJ; Gros P. 2001. Identification of a new chemically induced allele (lp(m1jus)) at the loop-tail locus: morphology, histology, and genetic mapping. Genomics 72(3):331-7. [PubMed: 11401449]  [MGI Ref ID J:68823]

Kibar Z; Vogan KJ; Groulx N; Justice MJ; Underhill DA; Gros P. 2001. Ltap, a mammalian homolog of Drosophila Strabismus/Van Gogh, is altered in the mouse neural tube mutant Loop-tail. Nat Genet 28(3):251-5. [PubMed: 11431695]  [MGI Ref ID J:70272]

Lu X; Borchers AG; Jolicoeur C; Rayburn H; Baker JC; Tessier-Lavigne M. 2004. PTK7/CCK-4 is a novel regulator of planar cell polarity in vertebrates. Nature 430(6995):93-8. [PubMed: 15229603]  [MGI Ref ID J:91298]

Montcouquiol M; Rachel RA; Lanford PJ; Copeland NG; Jenkins NA; Kelley MW. 2003. Identification of Vangl2 and Scrb1 as planar polarity genes in mammals. Nature 423(6936):173-7. [PubMed: 12724779]  [MGI Ref ID J:83127]

Montcouquiol M; Sans N; Huss D; Kach J; Dickman JD; Forge A; Rachel RA; Copeland NG; Jenkins NA; Bogani D; Murdoch J; Warchol ME; Wenthold RJ; Kelley MW. 2006. Asymmetric localization of Vangl2 and Fz3 indicate novel mechanisms for planar cell polarity in mammals. J Neurosci 26(19):5265-75. [PubMed: 16687519]  [MGI Ref ID J:108647]

Murdoch JN; Doudney K; Paternotte C; Copp AJ; Stanier P. 2001. Severe neural tube defects in the loop-tail mouse result from mutation of Lpp1, a novel gene involved in floor plate specification. Hum Mol Genet 10(22):2593-601. [PubMed: 11709546]  [MGI Ref ID J:72911]

Murdoch JN; Henderson DJ; Doudney K; Gaston-Massuet C; Phillips HM; Paternotte C; Arkell R; Stanier P; Copp AJ. 2003. Disruption of scribble (Scrb1) causes severe neural tube defects in the circletail mouse. Hum Mol Genet 12(2):87-98. [PubMed: 12499390]  [MGI Ref ID J:81365]

Murdoch JN; Rachel RA; Shah S; Beermann F; Stanier P; Mason CA; Copp AJ. 2001. Circletail, a new mouse mutant with severe neural tube defects: chromosomal localization and interaction with the loop-tail mutation. Genomics 78(1/2):55-63. [PubMed: 11707073]  [MGI Ref ID J:72608]

Petzold A; Stiefel D; Copp AJ. 2005. Amniotic fluid brain-specific proteins are biomarkers for spinal cord injury in experimental myelomeningocele. J Neurochem 95(2):594-8. [PubMed: 16190875]  [MGI Ref ID J:103589]

Phillips HM; Murdoch JN; Chaudhry B; Copp AJ; Henderson DJ. 2005. Vangl2 acts via RhoA signaling to regulate polarized cell movements during development of the proximal outflow tract. Circ Res 96(3):292-9. [PubMed: 15637299]  [MGI Ref ID J:106431]

Phillips HM; Rhee HJ; Murdoch JN; Hildreth V; Peat JD; Anderson RH; Copp AJ; Chaudhry B; Henderson DJ. 2007. Disruption of planar cell polarity signaling results in congenital heart defects and cardiomyopathy attributable to early cardiomyocyte disorganization. Circ Res 101(2):137-45. [PubMed: 17556662]  [MGI Ref ID J:137807]

Qian D; Jones C; Rzadzinska A; Mark S; Zhang X; Steel KP; Dai X; Chen P. 2007. Wnt5a functions in planar cell polarity regulation in mice. Dev Biol 306(1):121-33. [PubMed: 17433286]  [MGI Ref ID J:122585]

Reis JL; Correia-Pinto J; Monteiro MP; Hutchins GM. 2007. In utero topographic analysis of astrocytes and neuronal cells in the spinal cord of mutant mice with myelomeningocele. J Neurosurg 106(6 Suppl):472-9. [PubMed: 17566405]  [MGI Ref ID J:125330]

Ross AJ; May-Simera H; Eichers ER; Kai M; Hill J; Jagger DJ; Leitch CC; Chapple JP; Munro PM; Fisher S; Tan PL; Phillips HM; Leroux MR; Henderson DJ; Murdoch JN; Copp AJ; Eliot MM; Lupski JR; Kemp DT; Dollfus H; Tada M; Katsanis N; Forge A; Beales PL. 2005. Disruption of Bardet-Biedl syndrome ciliary proteins perturbs planar cell polarity in vertebrates. Nat Genet 37(10):1135-40. [PubMed: 16170314]  [MGI Ref ID J:102697]

SMITH LJ; STEIN KF. 1962. Axial elongation in the mouse and its retardation in homozygous looptail mice. J Embryol Exp Morphol 10:73-87. [PubMed: 14039372]  [MGI Ref ID J:12992]

STEIN KF; MACKENSEN JA. 1957. Abnormal development of the thoracic skeleton in mice homozygous for the gene for looped-tail. Am J Anat 100(2):205-23. [PubMed: 13435227]  [MGI Ref ID J:12147]

Saburi S; Hester I; Fischer E; Pontoglio M; Eremina V; Gessler M; Quaggin SE; Harrison R; Mount R; McNeill H. 2008. Loss of Fat4 disrupts PCP signaling and oriented cell division and leads to cystic kidney disease. Nat Genet 40(8):1010-5. [PubMed: 18604206]  [MGI Ref ID J:138247]

Satoh W; Matsuyama M; Takemura H; Aizawa S; Shimono A. 2008. Sfrp1, Sfrp2, and Sfrp5 regulate the Wnt/beta-catenin and the planar cell polarity pathways during early trunk formation in mouse. Genesis 46(2):92-103. [PubMed: 18257070]  [MGI Ref ID J:135313]

Snell GD; Dickie MM; Smith P; Kelton DE. 1954. Linkage of loop-tail, leaden, splotch and fuzzy in the mouse Heredity 8:271-273.  [MGI Ref ID J:120]

Stein KF; Rudin IA. 1953. Development of the mice homozygous for the gene for looptail J Hered 44:59-69.  [MGI Ref ID J:133114]

Strong LC; Hollander WF. 1949. Hereditary loop-tail in the house mouse accompanied by imperforate vagina and craniorachischisis when homozygous. J Hered 40:329-334.  [MGI Ref ID J:13059]

Torban E; Patenaude AM; Leclerc S; Rakowiecki S; Gauthier S; Andelfinger G; Epstein DJ; Gros P. 2008. Genetic interaction between members of the Vangl family causes neural tube defects in mice. Proc Natl Acad Sci U S A 105(9):3449-54. [PubMed: 18296642]  [MGI Ref ID J:132697]

Torban E; Wang HJ; Patenaude AM; Riccomagno M; Daniels E; Epstein D; Gros P. 2007. Tissue, cellular and sub-cellular localization of the Vangl2 protein during embryonic development: Effect of the Lp mutation. Gene Expr Patterns 7(3):346-54. [PubMed: 16962386]  [MGI Ref ID J:116150]

Wang J; Hamblet NS; Mark S; Dickinson ME; Brinkman BC; Segil N; Fraser SE; Chen P; Wallingford JB; Wynshaw-Boris A. 2006. Dishevelled genes mediate a conserved mammalian PCP pathway to regulate convergent extension during neurulation. Development 133(9):1767-78. [PubMed: 16571627]  [MGI Ref ID J:108512]

Wang J; Mark S; Zhang X; Qian D; Yoo SJ; Radde-Gallwitz K; Zhang Y; Lin X; Collazo A; Wynshaw-Boris A; Chen P. 2005. Regulation of polarized extension and planar cell polarity in the cochlea by the vertebrate PCP pathway. Nat Genet 37(9):980-5. [PubMed: 16116426]  [MGI Ref ID J:100861]

Wilson DB. 1985. An ultrastructural analysis of abnormal otic development in exencephalic mutant mice. Arch Otorhinolaryngol 241(2):203-8. [PubMed: 3977771]  [MGI Ref ID J:13370]

Wilson DB. 1983. Early development of the otocyst in an exencephalic mutant of the mouse. Acta Anat (Basel) 117(3):217-24. [PubMed: 6650116]  [MGI Ref ID J:133113]

Wilson DB. 1985. Ultrastructural analysis of basal neuroepithelial cells in dysraphic mice. Virchows Arch B Cell Pathol Incl Mol Pathol 48(1):9-17. [PubMed: 2858942]  [MGI Ref ID J:7801]

Wilson DB; Center EM. 1977. Differences in cerebral morphology in 2 stocks of mutant mice heterozygous for the loop-tail (Lp)-gene. Experientia 33(11):1502-3. [PubMed: 923728]  [MGI Ref ID J:5888]

Wilson DB; Center EM. 1974. The neural cell cycle in the looptail (Lp) mutant mouse. J Embryol Exp Morphol 32(3):698-705. [PubMed: 4477997]  [MGI Ref ID J:5550]

Wilson DB; Finta LA. 1980. Early development of the brain and spinal cord in dysraphic mice: a transmission electron microscopic study. J Comp Neurol 190(2):363-71. [PubMed: 6991554]  [MGI Ref ID J:133124]

Wilson DB; Michael SD. 1975. Surface defects in ventricular cells of brains of mouse embryos homozygous for the Loop-tail gene: scanning electron microscopic study. Teratology 11(1):87-98. [PubMed: 1138408]  [MGI Ref ID J:5544]

Wilson DB; Wyatt DP. 1992. Abnormal elevation of the neural folds in the loop-tail mutant mouse. Acta Anat (Basel) 143(2):89-95. [PubMed: 1598821]  [MGI Ref ID J:127]

Wilson DB; Wyatt DP. 1995. Alterations in cranial morphogenesis in the Lp mutant mouse. J Craniofac Genet Dev Biol 15(4):182-9. [PubMed: 8719347]  [MGI Ref ID J:31081]

Wilson DB; Wyatt DP. 1994. Analysis of neurulation in a mouse model for neural dysraphism. Exp Neurol 127(1):154-8. [PubMed: 8200433]  [MGI Ref ID J:18787]

Yamamoto S; Nishimura O; Misaki K; Nishita M; Minami Y; Yonemura S; Tarui H; Sasaki H. 2008. Cthrc1 selectively activates the planar cell polarity pathway of Wnt signaling by stabilizing the Wnt-receptor complex. Dev Cell 15(1):23-36. [PubMed: 18606138]  [MGI Ref ID J:140886]

Yang Z; Chen Y; Lillo C; Chien J; Yu Z; Michaelides M; Klein M; Howes KA; Li Y; Kaminoh Y; Chen H; Zhao C; Chen Y; Al-Sheikh YT; Karan G; Corbeil D; Escher P; Kamaya S; Li C; Johnson S; Frederick JM; Zhao Y; Wang C; Cameron DJ; Huttner WB; Schorderet DF;Munier FL; Moore AT; Birch DG; Baehr W; Hunt DM; Williams DS; Zhang K. 2008. Mutant prominin 1 found in patients with macular degeneration disrupts photoreceptor disk morphogenesis in mice. J Clin Invest 118(8):2908-16. [PubMed: 18654668]  [MGI Ref ID J:140984]

Ybot-Gonzalez P; Savery D; Gerrelli D; Signore M; Mitchell CE; Faux CH; Greene ND; Copp AJ. 2007. Convergent extension, planar-cell-polarity signalling and initiation of mouse neural tube closure. Development 134(4):789-99. [PubMed: 17229766]  [MGI Ref ID J:119920]

Zhou W; Lin L; Majumdar A; Li X; Zhang X; Liu W; Etheridge L; Shi Y; Martin J; Van de Ven W; Kaartinen V; Wynshaw-Boris A; McMahon AP; Rosenfeld MG; Evans SM. 2007. Modulation of morphogenesis by noncanonical Wnt signaling requires ATF/CREB family-mediated transcriptional activation of TGFbeta2. Nat Genet 39(10):1225-34. [PubMed: 17767158]  [MGI Ref ID J:125640]

van Abeelen JH. 1966. Behavioural profiles of neurological mutant mice. Genetica 37(2):149-58. [PubMed: 5955164]  [MGI Ref ID J:133042]

Health & husbandry

Health & Colony Maintenance Information

Currently there no information available for this strain. This may be due to the supply level of this strain.

Purchasing information

Pricing, Supply Level & Notes, Controls, General Terms & Conditions

Pricing

Supply Details

Standard Supply	Repository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information.
Supply Notes	Cryorecovery - Standard. The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two males and two females (two pairs) will be provided, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the delivery time to approximately 25 weeks. At least one member of each pair will be of known genotype and will carry the mutation if it is a mutant strain. Please note that pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Price represents a repository maintenance fee, which includes the cost of recovery of the strain from the cryopreservation resource and the periodic replacement of the frozen embryos used for recovery. Cryorecovery to establish a Dedicated Supply for greater quantities of mice. One to two pairs will be recovered to establish a Dedicated Supply of mice. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 or 1-207-288-5845. Genomic DNA is available for this strain from the Mouse DNA Resource.
Important Note	This strain is segregating for LtapLp.

Control Information

	Control
	Wild-type from the colony
Considerations for Choosing Controls
USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains.
International - Control Pricing Information for Genetically Engineered Mutant Strains.

General Terms and Conditions

See Terms of Use

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

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Ordering and Purchasing Information

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Tel: 800.422.6423 or 207.288.5845
Fax: 207.288.6150
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Terms of Use

Terms of Use

General Terms and Conditions

Contact information

General inquiries

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phone:	207-288-6470
fax:	207-288-6655

JAX^® Mice & Services Conditions of Use

“Each recipient institution, including its employees and other researchers under its control (RECIPIENT), of mice or services using mice from The Jackson Laboratory (TJL) agrees that such mice, descendants of those mice derived by inbreeding or crossbreeding, including unmodified derivatives of those mice or their descendants (“MICE”) shall not be: (i) used for any purpose other than the internal research of the RECIPIENT, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services with respect to MICE. Acceptance of MICE from TJL shall be deemed agreement by RECIPIENT to these conditions, and departure from these conditions requires The Jackson Laboratory’s prior written authorization.”

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of MICE, products or services, The Jackson Laboratory will, at its option, provide credit or replacement for the MICE or product received or the services provided.

No Liability

In no event shall The Jackson Laboratory, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, products or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of The Jackson Laboratory, its agents or employees. In purchasing or receiving MICE, products or services from The Jackson Laboratory, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges The Jackson Laboratory from all such causes of action or damages, and further agrees to defend and indemnify The Jackson Laboratory from any costs or damages arising out of any third party claims.

MICE and biological materials are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to The Jackson Laboratory’s MICE, products and services. In addition, special terms and conditions of sale of certain MICE, products and services may be set forth separately in The Jackson Laboratory web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, products and services by The Jackson Laboratory, and by its licensees and distributors.

Acceptance of delivery of MICE, products or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on The Jackson Laboratory, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, products services by The Jackson Laboratory.