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Former Names B6C3Fe-a/a-Alx4lst-J (Changed: 15-DEC-04 ) Type Mutant Strain; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Species laboratory mouse Generation N23p Development
The Strong?s luxoid Jackson mutation arose spontaneously in a linkage cross between bc and Fbn2fp and was subsequently maintained by crossing to a (C57BL/6J x C3FeLe.B6-a)F1 at each generation. In 1982 embryos were generated for cryopreservation from (C57BL/6J x C3FeLe.B6-a)F1 females bred with heterozygous males at generation N22 or N23.
Strains carrying a allele
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Strains carrying other alleles of a
View Strains carrying other alleles of a (81 strains)
View Mammalian Phenotype Terms
Mammalian Phenotype Terms
assigned by genotype
Alx4lst-J/Alx4lst-J
B6C3Fe a/a-Alx4lst-J/J
- skeleton phenotype
- small pubis (MGI Ref ID J:101708)
View Research Applications
Research Applications
This mouse can be used to support research in many areas including:Alx4lst-J related
Developmental Biology Research
Craniofacial and Palate Defects
Limb Patterning Defects
Mesodermal Defects
Skeletal Defects
Mouse/Human Gene Homologs
parietal foramina-2
Reproductive Biology Research
Fertility Defects
males only
| Allele Symbol | Alx4lst-J | ||
|---|---|---|---|
| Allele Name | Strong's luxoid Jackson | ||
| Allele Type | Spontaneous | ||
| Strain of Origin | STOCK Tyrp1 Tyr | ||
| Gene Symbol and Name | Alx4, aristaless-like homeobox 4 | ||
| Chromosome | 2 | ||
| Gene Common Name(s) | Aristaless-like 4; KIAA1788; Strong's luxoid; lst; | ||
| Molecular Note | The mutation is a 16 bp deletion in the sequences encoding the homeodomain, resulting in frameshift of the downstream coding sequence. [MGI Ref ID J:49152] | ||
| Allele Symbol | a | ||
| Allele Name | nonagouti | ||
| Allele Type | Spontaneous | ||
Genotyping Protocols
Alx41st-J, Restriction Enzyme Digest
Helpful Links
Genotyping resources and troubleshooting
Beverdam A; Brouwer A; Reijnen M; Korving J; Meijlink F. 2001. Severe nasal clefting and abnormal embryonic apoptosis in Alx3/Alx4 double mutant mice. Development 128(20):3975-86. [PubMed: 11641221] [MGI Ref ID J:71880]
Chan DC; Laufer E; Tabin C; Leder P. 1995. Polydactylous limbs in Strong's Luxoid mice result from ectopic polarizing activity. Development 121(7):1971-8. [PubMed: 7635045] [MGI Ref ID J:27786]
Qu S; Niswender KD; Ji Q; van der Meer R; Keeney D; Magnuson MA ; Wisdom R. 1997. Polydactyly and ectopic ZPA formation in Alx-4 mutant mice. Development 124(20):3999-4008. [PubMed: 9374397] [MGI Ref ID J:43769]
Takahashi M; Tamura K; Buscher D; Masuya H; Yonei-Tamura S; Matsumoto K; Naitoh-Matsuo M; Takeuchi J; Ogura K; Shiroishi T; Ogura T; Belmonte JC. 1998. The role of Alx-4 in the establishment of anteroposterior polarity during vertebrate limb development [published erratum appears in Development 1998 Dec;125(23):preceding 4595] Development 125(22):4417-25. [PubMed: 9778501] [MGI Ref ID J:50307]
Yada Y; Makino S; Chigusa-Ishiwa S; Shiroishi T. 2002. The mouse polydactylous mutation, luxate (lx), causes anterior shift of the anteroposterior border in the developing hindlimb bud. Int J Dev Biol 46(7):975-82. [PubMed: 12455637] [MGI Ref ID J:81331]
Alx4lst-J relatedBeverdam A; Brouwer A; Reijnen M; Korving J; Meijlink F. 2001. Severe nasal clefting and abnormal embryonic apoptosis in Alx3/Alx4 double mutant mice. Development 128(20):3975-86. [PubMed: 11641221] [MGI Ref ID J:71880]
Kuijper S; Beverdam A; Kroon C; Brouwer A; Candille S; Barsh G; Meijlink F. 2005. Genetics of shoulder girdle formation: roles of Tbx15 and aristaless-like genes. Development 132(7):1601-10. [PubMed: 15728667] [MGI Ref ID J:101708]
Kuijper S; Feitsma H; Sheth R; Korving J; Reijnen M; Meijlink F. 2005. Function and regulation of Alx4 in limb development: complex genetic interactions with Gli3 and Shh. Dev Biol 285(2):533-44. [PubMed: 16039644] [MGI Ref ID J:101265]
Panman L; Drenth T; Tewelscher P; Zuniga A; Zeller R. 2005. Genetic interaction of Gli3 and Alx4 during limb development. Int J Dev Biol 49(4):443-8. [PubMed: 15968591] [MGI Ref ID J:101476]
Qu S; Niswender KD; Ji Q; van der Meer R; Keeney D; Magnuson MA ; Wisdom R. 1997. Polydactyly and ectopic ZPA formation in Alx-4 mutant mice. Development 124(20):3999-4008. [PubMed: 9374397] [MGI Ref ID J:43769]
Qu S; Tucker SC; Ehrlich JS; Levorse JM; Flaherty LA; Wisdom R; Vogt TF. 1998. Mutations in mouse Aristaless-like4 cause Strong's luxoid polydactyly. Development 125(14):2711-21. [PubMed: 9636085] [MGI Ref ID J:49152]
Sweet HO; Davisson MT. 1995. Remutations at The Jackson Laboratory (Update to Mouse Genome 1993; 91:862-5 - J16313) Mouse Genome 93(4):1030-4. [MGI Ref ID J:30778]
Takahashi M; Tamura K; Buscher D; Masuya H; Yonei-Tamura S; Matsumoto K; Naitoh-Matsuo M; Takeuchi J; Ogura K; Shiroishi T; Ogura T; Belmonte JC. 1998. The role of Alx-4 in the establishment of anteroposterior polarity during vertebrate limb development [published erratum appears in Development 1998 Dec;125(23):preceding 4595] Development 125(22):4417-25. [PubMed: 9778501] [MGI Ref ID J:50307]
te Welscher P; Zuniga A; Kuijper S; Drenth T; Goedemans HJ; Meijlink F; Zeller R. 2002. Progression of vertebrate limb development through SHH-mediated counteraction of GLI3. Science 298(5594):827-30. [PubMed: 12215652] [MGI Ref ID J:79710]
Currently there no information available for this strain. This may be due to the supply level of this strain.
| Pricing for USA, Canada and Mexico shipping destinations |
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Animals Provided
Price (US dollars $) Cryorecovery Fee $1900.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
| Pricing for International shipping destinations |
|
Animals Provided
Price (US dollars $) Cryorecovery Fee $2470.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
| Standard Supply | Cryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information. |
|---|---|
| Supply Notes |
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Purchasing Information
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Contact Information
Orders & Technical Support
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Fax: 1-207-288-6150
Technical Support Email Form
| phone: | 207-288-6470 |
| fax: | 207-288-6655 |
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