Strain Name:

C3FeLe.B6 a/a-Ptpn6me/J

Stock Number:

000225

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Availability:

Cryopreserved - Ready for recovery

Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Former Names C3FeLe.B6 a/a-Hcphme/J    (Changed: 16-JUN-05 )
C3FeLe.B6 a/a-Hcphme/+    (Changed: 15-DEC-04 )
Type Congenic; Mutant Strain;
Additional information on Genetically Engineered and Mutant Mice.
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Additional information on Congenic nomenclature.
Specieslaboratory mouse
Background Strain C3HeB/FeJLe
Donor Strain C57BL/6J
H2 Haplotypek
GenerationN51F1+N1p (14-AUG-05)
Generation Definitions

Appearance
black
Related Genotype: a/a

Description
Mice homozygous for the motheaten spontaneous mutation (Ptpn6me) develop severe autoimmune disease. Characteristics include by granulocytic skin lesions, pneumonitis, impaired humoral and cell-mediated immune responses, decreased responses to T cell and B cell mitogens and deficient cytotoxic T cell and NK cell activity. B cells are LY-1+. Homozygous mutant mice also exhibit hyperimmunoglobulinemia, and express multiple autoantibodies. Macrophages show increased proliferative capacity. In addition to defects in the immune system, motheaten mice show classic symptoms of osteoporosis due to an increased number and activity of osteoclasts in the bone marrow. The lifespan of homozygous motheaten mice is approximately 3 weeks with death attributed to an autoimmune pneumonitis.

Control Information

  Control
   Untyped from the colony
 
  Considerations for Choosing Controls

Related Strains

Strains carrying   Ptpn6me allele
010825   C57BL/6J-Ptpn6me/SzJ
View Strains carrying   Ptpn6me     (1 strain)

Strains carrying   a allele
003879   B10;TFLe-a/a T Itpr3tf/+ Itpr3tf/J
001538   B6 x B6C3Sn a/A-T(1;9)27H/J
000916   B6 x B6C3Sn a/A-T(5;12)31H/J
000602   B6 x B6C3Sn a/A-T(8;16)17H/J
000618   B6 x FSB/GnEi a/a Ctslfs/J
000577   B6 x STOCK a Oca2p Hps5ru2 Ednrbs/J
000601   B6 x STOCK a/a T(7;18)50H/J
000592   B6 x STOCK T(2;4)13H a/J
014608   B6;129S1-a Kitlsl-24J/GrsrJ
000231   B6;C3Fe a/a-Csf1op/J
000785   B6;D2-a Ces1ce/EiJ
000604   B6C3 a/A-T(10;13)199H +/+ Lystbg-J/J or Lystbg-2J/J
001750   B6C3Fe a/a-Eif3cXs-J/J
002807   B6C3Fe a/a-Meox2fla/J
000506   B6C3Fe a/a-Qkqk-v/J
000224   B6C3Fe a/a-Scyl1mdf/J
003020   B6C3Fe a/a-Zdhhc21dep/J
001037   B6C3Fe a/a-Agtpbp1pcd/J
000221   B6C3Fe a/a-Alx4lst-J/J
002062   B6C3Fe a/a-Atp7aMo-8J/J
001756   B6C3Fe a/a-Cacng2stg/J
001815   B6C3Fe a/a-Col1a2oim/J
000209   B6C3Fe a/a-Dh/J
000211   B6C3Fe a/a-Dstdt-J/J
000210   B6C3Fe a/a-Edardl-J/J
000207   B6C3Fe a/a-Edaraddcr/J
000182   B6C3Fe a/a-Eef1a2wst/J
001278   B6C3Fe a/a-Glra1spd/J
000241   B6C3Fe a/a-Glrbspa/J
002875   B6C3Fe a/a-Hoxd13spdh/J
000304   B6C3Fe a/a-Krt71Ca Scn8amed-J/J
000226   B6C3Fe a/a-Largemyd/J
000636   B6C3Fe a/a-Lmx1adr-J/J
001280   B6C3Fe a/a-Lse/J
001573   B6C3Fe a/a-MitfMi/J
001035   B6C3Fe a/a-Napahyh/J
000181   B6C3Fe a/a-Otogtwt/J
000278   B6C3Fe a/a-Papss2bm Hps1ep Hps6ru/J
000205   B6C3Fe a/a-Papss2bm/J
002078   B6C3Fe a/a-Pcdh15av-2J/J
000246   B6C3Fe a/a-Pitpnavb/J
001430   B6C3Fe a/a-Ptch1mes/J
000235   B6C3Fe a/a-Relnrl/J
000237   B6C3Fe a/a-Rorasg/J
000290   B6C3Fe a/a-Sox10Dom/J
000230   B6C3Fe a/a-Tcirg1oc/J
003612   B6C3Fe a/a-Trak1hyrt/J
001512   B6C3Fe a/a-Ttnmdm/J
001607   B6C3Fe a/a-Unc5crcm/J
000005   B6C3Fe a/a-Wc/J
000243   B6C3Fe a/a-Wnt1sw/J
000248   B6C3Fe a/a-Xpl/J
000624   B6C3Fe a/a-anx/J
008044   B6C3Fe a/a-bpck/J
002018   B6C3Fe a/a-din/J
002339   B6C3Fe a/a-nma/J
000240   B6C3Fe a/a-soc/J
000063   B6C3Fe a/a-sy/J
001055   B6C3Fe a/a-tip/J
000245   B6C3Fe a/a-tn/J
000296   B6C3Fe-a/a Hoxa13Hd Mcoln3Va-J/J
000019   B6C3Fe-a/a-Itpr1opt/J
001022   B6C3FeF1/J a/a
006450   B6EiC3 a/A-Vss/GrsrJ
000971   B6EiC3 a/A-Och/J
000551   B6EiC3 a/A-Tbx15de-H/J
000557   B6EiC3-+ a/LnpUl A/J
000503   B6EiC3Sn a/A-Gy/J
001811   B6EiC3Sn a/A-Otcspf-ash/J
002343   B6EiC3Sn a/A-Otcspf/J
000391   B6EiC3Sn a/A-Pax6Sey-Dey/J
001923   B6EiC3Sn a/A-Ts(417)2Lws TimT(4;17)3Lws/J
000198   C3FeLe.B6-a/J
000291   C3FeLe.Cg-a/a Hm KitlSl Krt71Ca-J/J
001886   C3HeB/FeJLe a/a-gnd/J
000584   C57BL/6J-+ T(1;2)5Ca/a +/J
000284   CWD/LeJ
000670   DBA/1J
000671   DBA/2J
001057   HPT/LeJ
000260   JGBF/LeJ
000265   MY/HuLeJ
000308   SSL/LeJ
000994   STOCK a Myo5ad Mregdsu/J
000064   STOCK a Tyrp1b Pmelsi/J
002238   STOCK a Tyrp1b shmy/J
001433   STOCK a skt/J
000579   STOCK a tp/J
000319   STOCK a us/J
002648   STOCK a/a Cln6nclf/J
000317   STOCK a/a Egfrwa2/J
000302   STOCK a/a MitfMi-wh +/+ Itpr1opt/J
000286   STOCK a/a Myo5ad fd/+ +/J
000281   STOCK a/a Tmem79ma Flgft/J
000206   STOCK a/a Tyrc-h/J
001432   STOCK a/a Tyrp1b Ndc1sks/Tyrp1b +/J
000312   STOCK stb + a/+ Fignfi a/J
000596   STOCK T(2;11)30H/+ x AEJ-a Gdf5bp-H/J or A/J-a Gdf5bp-J/J
000970   STOCK T(2;16)28H A/T(2;16)28H a/J
000590   STOCK T(2;4)1Sn a/J
000594   STOCK T(2;8)26H a/T(2;8)26H a Tyrp1+/Tyrp1b/J
000623   TR/DiEiJ
View Strains carrying   a     (102 strains)

Strains carrying other alleles of Ptpn6
008336   B6.129P2-Ptpn6tm1Rsky/J
000811   C57BL/6J-Ptpn6me-v/J
View Strains carrying other alleles of Ptpn6     (2 strains)

Strains carrying other alleles of a
002655   Mus pahari/EiJ
000251   AEJ.Cg-ae +/a Gdf5bp-H/J
000202   AEJ/Gn-bd/J
000199   AEJ/GnLeJ
000433   B10.C-H3c H13? A/(28NX)SnJ
000427   B10.CE-H13b Aw/(30NX)SnJ
000423   B10.KR-H13? A/SnJ
000420   B10.LP-H13b Aw/Sn
000477   B10.PA-Bloc1s6pa H3e at/SnJ
000419   B10.UW-H3b we Pax1un at/SnJ
000593   B6 x B6CBCa Aw-J/A-Grid2Lc T(2;6)7Ca MitfMi-wh/J
000502   B6 x B6CBCa Aw-J/A-Myo5aflr Gnb5flr/J
000599   B6 x B6CBCa Aw-J/A-T(5;13)264Ca KitW-v/J
002083   B6 x B6EiC3 a/A-T(7;16)235Dn/J
000507   B6 x B6EiC3 a/A-Otcspf/J
003759   B6 x B6EiC3Sn a/A-T(10;16)232Dn/J
002071   B6 x B6EiC3Sn a/A-T(11;17)202Dn/J
002113   B6 x B6EiC3Sn a/A-T(11A2;16B3)238Dn/J
002068   B6 x B6EiC3Sn a/A-T(11B1;16B5)233Dn/J
002069   B6 x B6EiC3Sn a/A-T(14E4or5;16B5)225Dn/J
001926   B6 x B6EiC3Sn a/A-T(15;16)198Dn/J
001832   B6 x B6EiC3Sn a/A-T(15E;16B1)60Dn/J
003758   B6 x B6EiC3Sn a/A-T(16C3-4;17A2)65Dn/J
001833   B6 x B6EiC3Sn a/A-T(1C2;16C3)45Dn/J
001903   B6 x B6EiC3Sn a/A-T(6F;18C)57Dn/J
001535   B6 x B6EiC3Sn a/A-T(8A4;12D1)69Dn/J
001831   B6 x B6EiC3Sn a/A-T(8C3;16B5)164Dn/J
002016   B6(Cg)-Aw-J EdaTa-6J Chr YB6-Sxr/EiJ
000600   B6-Gpi1b x B6CBCa Aw-J/A-T(7;15)9H Gpi1a/J
000769   B6.C/(HZ18)By-at-44J/J
000203   B6.C3-Aiy/a/J
000017   B6.C3-Avy/J
001572   B6.C3-am-J/J
000628   B6.CE-A Amy1b Amy2a5b/J
001809   B6.Cg-Aw-J EdaTa-6J +/+ ArTfm/J
000552   B6.Cg-Aw-J EdaTa-6J Sxr
001730   B6.Cg-Aw-J EdaTa-6J Sxrb Hya-/J
000841   B6.Cg-Aw-J EdaTa-By/J
000021   B6.Cg-Ay/J
100409   B6129PF1/J-Aw-J/Aw
004200   B6;CBACa Aw-J/A-Npr2cn-2J/GrsrJ
000505   B6C3 Aw-J/A-Bloc1s5mu/J
000604   B6C3 a/A-T(10;13)199H +/+ Lystbg-J/J or Lystbg-2J/J
000065   B6C3Fe a/a-we Pax1un at/J
003301   B6C3FeF1 a/A-Eya1bor/J
000314   B6CBACa Aw-J/A-EdaTa/J-XO
000501   B6CBACa Aw-J/A-Aifm1Hq/J
001046   B6CBACa Aw-J/A-Grid2Lc/J
000500   B6CBACa Aw-J/A-Gs/J
002703   B6CBACa Aw-J/A-Hydinhy3/J
000247   B6CBACa Aw-J/A-Kcnj6wv/J
000287   B6CBACa Aw-J/A-Plp1jp EdaTa/J
000515   B6CBACa Aw-J/A-SfnEr/J
000242   B6CBACa Aw-J/A-spc/J
000288   B6CBACa Aw-J/A-we a Mafbkr/J
001201   B6CBACaF1/J-Aw-J/A
006450   B6EiC3 a/A-Vss/GrsrJ
000557   B6EiC3-+ a/LnpUl A/J
000504   B6EiC3Sn a/A-Cacnb4lh/J
000553   B6EiC3Sn a/A-Egfrwa2 Wnt3avt/J
001811   B6EiC3Sn a/A-Otcspf-ash/J
002343   B6EiC3Sn a/A-Otcspf/J
001923   B6EiC3Sn a/A-Ts(417)2Lws TimT(4;17)3Lws/J
001875   B6EiC3SnF1/J
000638   C3FeB6 A/Aw-J-Sptbn4qv-J/J
000200   C3FeB6 A/Aw-J-Ankank/J
001203   C3FeB6F1/J A/Aw-J
001272   C3H/HeSnJ-Ahvy/J
000099   C3HeB/FeJ-Avy/J
000338   C57BL/6J Aw-J-EdaTa-6J/J
000258   C57BL/6J-Ai/a/J
000774   C57BL/6J-Asy/a/J
000569   C57BL/6J-Aw-J-EdaTa +/+ ArTfm/J
000051   C57BL/6J-Aw-J/J
000055   C57BL/6J-at-33J/J
000070   C57BL/6J-atd/J
002468   KK.Cg-Ay/J
000262   LS/LeJ
000283   LT.CAST-A/J
001759   STOCK A Tyrc Sha/J
001427   STOCK Aw us/J
001145   WSB/EiJ
View Strains carrying other alleles of a     (82 strains)

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

Ptpn6me/Ptpn6me

        C3FeLe.B6 a/a-Ptpn6me/J
  • nervous system phenotype
  • abnormal microglial cell activation
    • significantly activated relative to controls as measured in the anteroventricular cochlear nucleus when unilateral cochlear ablation is performed at 14 days   (MGI Ref ID J:88807)
    • microglial cells seem transformed to the amoeboid activated state   (MGI Ref ID J:88807)
    • level of activation is significantly higher at 4 days after operation but not at 2 or 6 days   (MGI Ref ID J:88807)
    • no activation if cochlear ablation is performed at 5 days of age   (MGI Ref ID J:88807)
    • no difference from controls if ablation performed at 21 days of age   (MGI Ref ID J:88807)
  • decreased neuron number
    • neuronal cell loss in the anteroventricular cochlear nucleus is high relative to controls in mice operated on at 14 days   (MGI Ref ID J:88807)
    • unilateral cochlear ablation at 21 days has little effect on neuronal cell loss in either mutant or control mice   (MGI Ref ID J:88807)
  • immune system phenotype
  • abnormal microglial cell activation
    • significantly activated relative to controls as measured in the anteroventricular cochlear nucleus when unilateral cochlear ablation is performed at 14 days   (MGI Ref ID J:88807)
    • microglial cells seem transformed to the amoeboid activated state   (MGI Ref ID J:88807)
    • level of activation is significantly higher at 4 days after operation but not at 2 or 6 days   (MGI Ref ID J:88807)
    • no activation if cochlear ablation is performed at 5 days of age   (MGI Ref ID J:88807)
    • no difference from controls if ablation performed at 21 days of age   (MGI Ref ID J:88807)
  • hematopoietic system phenotype
  • abnormal microglial cell activation
    • significantly activated relative to controls as measured in the anteroventricular cochlear nucleus when unilateral cochlear ablation is performed at 14 days   (MGI Ref ID J:88807)
    • microglial cells seem transformed to the amoeboid activated state   (MGI Ref ID J:88807)
    • level of activation is significantly higher at 4 days after operation but not at 2 or 6 days   (MGI Ref ID J:88807)
    • no activation if cochlear ablation is performed at 5 days of age   (MGI Ref ID J:88807)
    • no difference from controls if ablation performed at 21 days of age   (MGI Ref ID J:88807)

The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.

Ptpn6me/Ptpn6me

        C57BL/6J-Ptpn6me/J
  • mortality/aging
  • partial preweaning lethality
    • high mortality before weaning   (MGI Ref ID J:5579)
  • pigmentation phenotype
  • abnormal skin pigmentation
    • recognized at 3 to 4 days of age by patchy absence of skin pigment   (MGI Ref ID J:5579)
  • immune system phenotype
  • abnormal Peyer's patch morphology
    • rarely any differentiation of lymphoid tissue into nodules is found   (MGI Ref ID J:5579)
    • lymphocytes are larger and sparsely distributed   (MGI Ref ID J:5579)
  • abnormal humoral immune response
    • mice are deficient in capacity for immune response   (MGI Ref ID J:5579)
    • increased immunoglobulin level   (MGI Ref ID J:5579)
      • increased IgA level
        • serum levels are elevated   (MGI Ref ID J:5579)
      • increased IgG level
        • serum levels are elevated   (MGI Ref ID J:5579)
      • increased IgM level
        • serum levels are markedly elevated above normal   (MGI Ref ID J:5579)
  • abnormal immune system cell morphology
    • mice have a population of unusual binucleate lymphocytes   (MGI Ref ID J:5579)
    • abnormal granulocyte morphology
      • differential counts of blood from 1 to 3 day old mice showed an immature granuloctye population   (MGI Ref ID J:5579)
    • abnormal leukocyte cell number   (MGI Ref ID J:5579)
      • increased leukocyte cell number   (MGI Ref ID J:5579)
        • increased granulocyte number   (MGI Ref ID J:5579)
        • increased monocyte cell number   (MGI Ref ID J:5579)
  • abnormal thymus morphology   (MGI Ref ID J:5579)
    • small thymus
      • although smaller than normal, the thymus is histologically normal until 25 days of age   (MGI Ref ID J:5579)
      • severe involution and necrosis is found in sick mice, with severity correlating with degree of illness   (MGI Ref ID J:5579)
  • enlarged spleen   (MGI Ref ID J:5579)
  • hematopoietic system phenotype
  • abnormal granulocyte morphology
    • differential counts of blood from 1 to 3 day old mice showed an immature granuloctye population   (MGI Ref ID J:5579)
  • abnormal leukocyte cell number   (MGI Ref ID J:5579)
    • increased leukocyte cell number   (MGI Ref ID J:5579)
      • increased granulocyte number   (MGI Ref ID J:5579)
      • increased monocyte cell number   (MGI Ref ID J:5579)
  • abnormal thymus morphology   (MGI Ref ID J:5579)
    • small thymus
      • although smaller than normal, the thymus is histologically normal until 25 days of age   (MGI Ref ID J:5579)
      • severe involution and necrosis is found in sick mice, with severity correlating with degree of illness   (MGI Ref ID J:5579)
  • enlarged spleen   (MGI Ref ID J:5579)
  • increased immunoglobulin level   (MGI Ref ID J:5579)
    • increased IgA level
      • serum levels are elevated   (MGI Ref ID J:5579)
    • increased IgG level
      • serum levels are elevated   (MGI Ref ID J:5579)
    • increased IgM level
      • serum levels are markedly elevated above normal   (MGI Ref ID J:5579)
  • respiratory system phenotype
  • abnormal lung morphology
    • mice develop lesions in the lung by 3 days of age   (MGI Ref ID J:5579)
  • cellular phenotype
  • abnormal cell cycle   (MGI Ref ID J:66843)
    • abnormal cell cycle checkpoint function
      • there is a higher than normal percentage of splenocytes in S and G2/M (22% instead of 7%) and corresponding decrease in splenocytes in G0/G1 (73% instead of 89%)   (MGI Ref ID J:66843)
      • 6 hours after 5 Gy of gamma irradiation homozygous splenocytes show abnormal cell cycle arrest, with 31% instead of the wild-type 4% in S+G2/M phases, and fewer irradiated splenocytes are found in the subG0 (hyplodiploid) state (15% instead of 45%)   (MGI Ref ID J:66843)
  • decreased apoptosis
    • only 21% of spleen cells are apoptotic 6 hours after exposure to 5 Gy gamma irradiation, whereas 40% of wildtype splenocytes are apoptotic after treatment.   (MGI Ref ID J:66843)
    • B and T cells show the greatest resistance to apoptosis in the splenocyte population, but all splenic cell types including macrophages and granulocytes have greater resistance to apoptosis than wildtype cells   (MGI Ref ID J:66843)
    • splenocytoes from homozygotes have much less disruption of mitochondrial transmembrane potential at 6 and 24 hours post-exposure to 5 Gy of gamma irradiation and do not show the normal increase in expression of Bax   (MGI Ref ID J:66843)
  • decreased cellular sensitivity to gamma-irradiation
    • the LD50 for homozygous spleen cells is 24.5 Gy gamma radiation versus 6.5 Gy for wildtype splenocytes   (MGI Ref ID J:66843)
  • integument phenotype
  • abnormal skin pigmentation
    • recognized at 3 to 4 days of age by patchy absence of skin pigment   (MGI Ref ID J:5579)
  • focal hair loss
    • patchy absence of hair in the coat gives mice a motheaten appearance   (MGI Ref ID J:5579)
  • skin lesions
    • rapidly progressing lesions develop on the feet by 3 weeks of age   (MGI Ref ID J:5579)
    • as early as 2 days after birth abscesses appear on the skin, rupture and begin to heal in 24 hrs   (MGI Ref ID J:5579)

Ptpn6me/Ptpn6me

        involves: C3H/HeN * C57BL/6J * NFS
  • mortality/aging
  • premature death
    • life span about 8 weeks whereas on a C57BL/6 background survival is about 3 weeks   (MGI Ref ID J:30994)
    • occasional survival to 16 weeks on an NFS or C3H background for larger individuals   (MGI Ref ID J:30994)
  • growth/size/body phenotype
  • decreased body weight
    • weigh about 66% of control weight   (MGI Ref ID J:30994)
  • limbs/digits/tail phenotype
  • absent limbs
    • autoamputation of 2-3 extremities by 8 weeks of age   (MGI Ref ID J:30994)
  • integument phenotype
  • abnormal skin condition
    • cutaneous granulomatous lesions at 8 weeks   (MGI Ref ID J:30994)
  • cellular phenotype
  • increased splenocyte proliferation
    • lack of stimulatory effect of ConA   (MGI Ref ID J:30994)
  • hematopoietic system phenotype
  • increased IgM level
    • increased secretion by splenocytes in culture   (MGI Ref ID J:30994)
    • serum levels elevated relative to controls   (MGI Ref ID J:30994)
  • increased splenocyte proliferation
    • lack of stimulatory effect of ConA   (MGI Ref ID J:30994)
  • immune system phenotype
  • increased IgM level
    • increased secretion by splenocytes in culture   (MGI Ref ID J:30994)
    • serum levels elevated relative to controls   (MGI Ref ID J:30994)
  • increased autoantibody level   (MGI Ref ID J:30994)
  • increased splenocyte proliferation
    • lack of stimulatory effect of ConA   (MGI Ref ID J:30994)

Ptpn6me/Ptpn6me

        involves: C3HeB/FeJ * C57BL/6
  • mortality/aging
  • complete postnatal lethality
    • death at around 3 weeks of age involving intra alveolar hemorrhage   (MGI Ref ID J:72655)
  • growth/size/body phenotype
  • decreased body weight
    • about half of controls   (MGI Ref ID J:72655)
  • nervous system phenotype
  • abnormal myelination
    • decreased   (MGI Ref ID J:72655)
  • abnormal nervous system morphology   (MGI Ref ID J:72655)
    • abnormal CNS glial cell morphology   (MGI Ref ID J:72655)
      • abnormal astrocyte morphology
        • GFAP+ astrocytes decreased about 50% on both the hippocampus and the forebrain fiber tracts   (MGI Ref ID J:72655)
      • abnormal microglial cell morphology
        • F4/80+ microglial cells are reduced in number   (MGI Ref ID J:72655)
    • abnormal forebrain morphology   (MGI Ref ID J:72655)
      • abnormal hippocampus CA1 region morphology
        • about 20% more neurons present   (MGI Ref ID J:72655)
      • abnormal hippocampus development
        • scattered areas of focal necrosis   (MGI Ref ID J:72655)
      • abnormal telencephalon development
        • scattered areas of focal necrosis in the cortex   (MGI Ref ID J:72655)
    • decreased brain size
      • length and width decreased   (MGI Ref ID J:72655)
      • weight normal   (MGI Ref ID J:72655)
  • respiratory system phenotype
  • abnormal pulmonary alveolar system morphology
    • intra alveolar hemorrhage around 3 weeks of age leading to death   (MGI Ref ID J:72655)
  • hematopoietic system phenotype
  • abnormal microglial cell morphology
    • F4/80+ microglial cells are reduced in number   (MGI Ref ID J:72655)
  • immune system phenotype
  • abnormal microglial cell morphology
    • F4/80+ microglial cells are reduced in number   (MGI Ref ID J:72655)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Immunology, Inflammation and Autoimmunity Research
Autoimmunity

Internal/Organ Research
Skeleton
      Bone

Ptpn6me related

Apoptosis Research

Dermatology Research
Skin and Hair Texture Defects

Endocrine Deficiency Research
Bone/Bone Marrow Defects
Thyroid Defects

Immunology, Inflammation and Autoimmunity Research
Autoimmunity
Immunodeficiency
Inflammation

Internal/Organ Research
Lymphoid Tissue Defects
Spleen Defects

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Ptpn6me
Allele Name motheaten
Allele Type Spontaneous
Common Name(s) SHP-1 deficient; me;
Strain of OriginC57BL/6J
Gene Symbol and Name Ptpn6, protein tyrosine phosphatase, non-receptor type 6
Chromosome 6
Gene Common Name(s) HCP; HCPH; HPTP1C; Hcph; PTP-1C; Ptp1C; Ptph6; SH-PTP1; SHP-1; SHP-1L; SHP1; Spin; hemopoietic cell phosphatase; me; motheaten;
General Note Homozygotes are characterized by early onset autoimmunity and severe immunodeficiency (J:5579). Mice develop an unusual pneumonia which progresses to accumulation of crystal-containing macrophages in the alveoli (J:5999). Spleen macrophages of homozygotes have an accelerated rate of proliferation which may contribute to the pulmonary disease (J:7274). The number of surface-Ig-bearing lymphocytes (B-cells) is greatly reduced, and the B-cells present are of immature rather than adult type (J:6065). The number of T-cells is normal, but several T-cell functions are defective. Natural killer cell activity is virtually absent (J:6485).

Genbank ID for this mutation: S63764

Molecular Note A single nucleotide (C) deletion at position 228 creates a cryptic splice site. This results in the deletion of a 101bp segment in the encoded transcript, and a frameshift in the encoded protein. [MGI Ref ID J:11892] [MGI Ref ID J:60297]
 
Allele Symbol a
Allele Name nonagouti
Allele Type Spontaneous
Strain of Originold mutant of the mouse fancy
Gene Symbol and Name a, nonagouti
Chromosome 2
Gene Common Name(s) AGSW; AGTI; AGTIL; ASP; As; SHEP9; agouti; agouti signal protein; agouti suppressor;
Molecular Note Characterization of this allele shows an insertion of DNA comprised of a 5.5kb virus-like element, VL30, into the first intron of the agouti gene. The VL30 element itself contains an additional 5.5 kb sequence, flanked by 526 bp of direct repeats. The host integration site is the same as for at-2Gso and Aw-38J and includes a duplication of four nucleotides of host DNA and a deletion of 2 bp from the end of each repeat. Northern analysis of mRNA from skin of homozygotes shows a smaller agouti message and levels 8 fold lower than found in wild-type. [MGI Ref ID J:16984] [MGI Ref ID J:24934]

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Ptpn6me, Restriction Enzyme Digest


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References

References provided by MGI

Additional References

Clark EA; Shultz LD; Pollack SB. 1981. Mutations in mice that influence natural killer (NK) cell activity. Immunogenetics 12(5-6):601-13. [PubMed: 6971254]  [MGI Ref ID J:6485]

Davidson WF; Morse HC 3rd; Sharrow SO; Chused TM. 1979. Phenotypic and functional effects of the motheaten gene on murine B and T lymphocytes. J Immunol 122(3):884-91. [PubMed: 221571]  [MGI Ref ID J:6135]

Green MC; Shultz LD. 1975. Motheaten, an immunodeficient mutant of the mouse. I. Genetics and pathology. J Hered 66(5):250-8. [PubMed: 1184950]  [MGI Ref ID J:5579]

Kozlowski M; Mlinaric-Rascan I; Feng GS; Shen R; Pawson T; Siminovitch KA. 1993. Expression and catalytic activity of the tyrosine phosphatase PTP1C is severely impaired in motheaten and viable motheaten mice. J Exp Med 178(6):2157-63. [PubMed: 8245788]  [MGI Ref ID J:15725]

McCoy KL; Clagett J; Rosse C. 1985. Effects of the motheaten gene on murine B-cell production. Exp Hematol 13(6):554-9. [PubMed: 3873348]  [MGI Ref ID J:7856]

McCoy KL; Nielson K; Clagett J. 1984. Spontaneous production of colony-stimulating activity by splenic Mac-1 antigen-positive cells from autoimmune motheaten mice. J Immunol 132(1):272-6. [PubMed: 6361123]  [MGI Ref ID J:7274]

Mlinaric-Rascan I; Asa SL; Siminovitch KA. 1994. Increased expression of the stefin A cysteine proteinase inhibitor occurs in the myelomonocytic cell-infiltrated tissues of autoimmune motheaten mice. Am J Pathol 145(4):902-12. [PubMed: 7943179]  [MGI Ref ID J:20878]

Shultz LD; Green MC. 1976. Motheaten, an immunodeficient mutant of the mouse. II. Depressed immune competence and elevated serum immunoglobulins. J Immunol 116(4):936-43. [PubMed: 56406]  [MGI Ref ID J:5624]

Shultz LD; Schweitzer PA; Rajan TV; Yi T; Ihle JN; Matthews RJ; Thomas ML; Beier DR. 1993. Mutations at the murine motheaten locus are within the hematopoietic cell protein-tyrosine phosphatase (Hcph) gene. Cell 73(7):1445-54. [PubMed: 8324828]  [MGI Ref ID J:14935]

Sidman CL; Shultz LD; Unanue ER. 1978. The mouse mutant motheaten. II. Functional studies of the immune system. J Immunol 121(6):2399-404. [PubMed: 363947]  [MGI Ref ID J:6065]

Tsui HW; Siminovitch KA; de Souza L; Tsui FW. 1993. Motheaten and viable motheaten mice have mutations in the haematopoietic cell phosphatase gene. Nat Genet 4(2):124-9. [PubMed: 8348149]  [MGI Ref ID J:11892]

Wishcamper CA; Coffin JD; Lurie DI. 2001. Lack of the protein tyrosine phosphatase SHP-1 results in decreased numbers of glia within the motheaten (me/me) mouse brain. J Comp Neurol 441(2):118-33. [PubMed: 11745639]  [MGI Ref ID J:72655]

Yi T; Gilbert DJ; Jenkins NA; Copeland NG; Ihle JN. 1992. Assignment of a novel protein tyrosine phosphatase gene (Hcph) to mouse chromosome 6. Genomics 14(3):793-5. [PubMed: 1427910]  [MGI Ref ID J:3085]

Zhao J; Lurie DI. 2004. Cochlear ablation in mice lacking SHP-1 results in an extended period of cell death of anteroventral cochlear nucleus neurons. Hear Res 189(1-2):63-75. [PubMed: 14987753]  [MGI Ref ID J:88807]

Ptpn6me related

Abram CL; Roberge GL; Pao LI; Neel BG; Lowell CA. 2013. Distinct roles for neutrophils and dendritic cells in inflammation and autoimmunity in motheaten mice. Immunity 38(3):489-501. [PubMed: 23521885]  [MGI Ref ID J:195276]

Aloulou M; Ben Mkaddem S; Biarnes-Pelicot M; Boussetta T; Souchet H; Rossato E; Benhamou M; Crestani B; Zhu Z; Blank U; Launay P; Monteiro RC. 2012. IgG1 and IVIg induce inhibitory ITAM signaling through FcgammaRIII controlling inflammatory responses. Blood 119(13):3084-96. [PubMed: 22337713]  [MGI Ref ID J:182509]

Berg KL; Siminovitch KA; Stanley ER. 1999. SHP-1 regulation of p62(DOK) tyrosine phosphorylation in macrophages. J Biol Chem 274(50):35855-65. [PubMed: 10585470]  [MGI Ref ID J:58900]

Bignon JS; Siminovitch KA. 1994. Identification of PTP1C mutation as the genetic defect in motheaten and viable motheaten mice: a step toward defining the roles of protein tyrosine phosphatases in the regulation of hemopoietic cell differentiation and function. Clin Immunol Immunopathol 73(2):168-79. [PubMed: 7923924]  [MGI Ref ID J:21151]

Bonaparte KL; Hudson CA; Wu C; Massa PT. 2006. Inverse regulation of inducible nitric oxide synthase (iNOS) and arginase I by the protein tyrosine phosphatase SHP-1 in CNS glia. Glia 53(8):827-35. [PubMed: 16565987]  [MGI Ref ID J:156128]

Carter JD; Calabrese GM; Naganuma M; Lorenz U. 2005. Deficiency of the Src homology region 2 domain-containing phosphatase 1 (SHP-1) causes enrichment of CD4+CD25+ regulatory T cells. J Immunol 174(11):6627-38. [PubMed: 15905501]  [MGI Ref ID J:99043]

Carter JD; Neel BG; Lorenz U. 1999. The tyrosine phosphatase SHP-1 influences thymocyte selection by setting TCR signaling thresholds. Int Immunol 11(12):1999-2014. [PubMed: 10590266]  [MGI Ref ID J:59134]

Christophi GP; Hudson CA; Panos M; Gruber RC; Massa PT. 2009. Modulation of macrophage infiltration and inflammatory activity by the phosphatase SHP-1 in virus-induced demyelinating disease. J Virol 83(2):522-39. [PubMed: 18987138]  [MGI Ref ID J:153390]

Clark EA; Shultz LD; Pollack SB. 1981. Mutations in mice that influence natural killer (NK) cell activity. Immunogenetics 12(5-6):601-13. [PubMed: 6971254]  [MGI Ref ID J:6485]

Croker BA; Lawson BR; Berger M; Eidenschenk C; Blasius AL; Moresco EM; Sovath S; Cengia L; Shultz LD; Theofilopoulos AN; Pettersson S; Beutler BA. 2008. Inflammation and autoimmunity caused by a SHP1 mutation depend on IL-1, MyD88, and a microbial trigger. Proc Natl Acad Sci U S A 105(39):15028-33. [PubMed: 18806225]  [MGI Ref ID J:142845]

Davidson D; Bakinowski M; Thomas ML; Horejsi V; Veillette A. 2003. Phosphorylation-dependent regulation of T-cell activation by PAG/Cbp, a lipid raft-associated transmembrane adaptor. Mol Cell Biol 23(6):2017-28. [PubMed: 12612075]  [MGI Ref ID J:113969]

Fowler CC; Pao LI; Blattman JN; Greenberg PD. 2010. SHP-1 in T cells limits the production of CD8 effector cells without impacting the formation of long-lived central memory cells. J Immunol 185(6):3256-67. [PubMed: 20696858]  [MGI Ref ID J:163839]

Green MC; Shultz LD. 1975. Motheaten, an immunodeficient mutant of the mouse. I. Genetics and pathology. J Hered 66(5):250-8. [PubMed: 1184950]  [MGI Ref ID J:5579]

Hsu HC; Shultz LD; Su X; Shi J; Yang PA; Relyea MJ; Zhang HG; Mountz JD. 2001. Mutation of the hematopoietic cell phosphatase (Hcph) gene is associated with resistance to gamma-irradiation-induced apoptosis in Src homology protein tyrosine phosphatase (SHP)-1-deficient 'motheaten' mutant mice. J Immunol 166(2):772-80. [PubMed: 11145649]  [MGI Ref ID J:66843]

Inoue T; Suzuki Y; Mizuno K; Nakata K; Yoshimaru T; Ra C. 2009. SHP-1 exhibits a pro-apoptotic function in antigen-stimulated mast cells: positive regulation of mitochondrial death pathways and negative regulation of survival signaling pathways. Mol Immunol 47(2-3):222-32. [PubMed: 19875169]  [MGI Ref ID J:155341]

Iype T; Sankarshanan M; Mauldin IS; Mullins DW; Lorenz U. 2010. The protein tyrosine phosphatase SHP-1 modulates the suppressive activity of regulatory T cells. J Immunol 185(10):6115-27. [PubMed: 20952680]  [MGI Ref ID J:165785]

Jiao H; Yang W; Berrada K; Tabrizi M; Shultz L; Yi T. 1997. Macrophages from motheaten and viable motheaten mutant mice show increased proliferative responses to GM-CSF: detection of potential HCP substrates in GM-CSF signal transduction. Exp Hematol 25(7):592-600. [PubMed: 9216734]  [MGI Ref ID J:41396]

Johnson KG; LeRoy FG; Borysiewicz LK; Matthews RJ. 1999. TCR signaling thresholds regulating T cell development and activation are dependent upon SHP-1. J Immunol 162(7):3802-13. [PubMed: 10201897]  [MGI Ref ID J:53576]

Kamata T; Yamashita M; Kimura M; Murata K; Inami M; Shimizu C; Sugaya K; Wang CR; Taniguchi M; Nakayama T. 2003. src homology 2 domain-containing tyrosine phosphatase SHP-1 controls the development of allergic airway inflammation. J Clin Invest 111(1):109-19. [PubMed: 12511594]  [MGI Ref ID J:81122]

Kon-Kozlowski M; Pani G; Pawson T; Siminovitch KA. 1996. The tyrosine phosphatase PTP1C associates with Vav, Grb2, and mSos1 in hematopoietic cells. J Biol Chem 271(7):3856-62. [PubMed: 8632004]  [MGI Ref ID J:31423]

Kozlowski M; Mlinaric-Rascan I; Feng GS; Shen R; Pawson T; Siminovitch KA. 1993. Expression and catalytic activity of the tyrosine phosphatase PTP1C is severely impaired in motheaten and viable motheaten mice. J Exp Med 178(6):2157-63. [PubMed: 8245788]  [MGI Ref ID J:15725]

Kruger J; Butler JR; Cherapanov V; Dong Q; Ginzberg H; Govindarajan A; Grinstein S; Siminovitch KA; Downey GP. 2000. Deficiency of Src homology 2-containing phosphatase 1 results in abnormalities in murine neutrophil function: studies in motheaten mice. J Immunol 165(10):5847-59. [PubMed: 11067945]  [MGI Ref ID J:118386]

Kuntz L; Jachez B; Roman D; Loor F. 1993. Modulation of adoptively transferred viable motheaten pathology in sublethally irradiated normal recipient mice by normal hematopoietic cells. Cell Immunol 146(1):215-21. [PubMed: 8093859]  [MGI Ref ID J:3800]

Lorenz U; Bergemann AD; Steinberg HN; Flanagan JG; Li X; Galli SJ; Neel BG. 1996. Genetic analysis reveals cell type-specific regulation of receptor tyrosine kinase c-Kit by the protein tyrosine phosphatase SHP1. J Exp Med 184(3):1111-26. [PubMed: 9064328]  [MGI Ref ID J:35276]

Lutzner MA; Hansen CT. 1976. Motheater: an immunodeficient mouse with markedly less ability to survive that the nude mouse in a germfree environment. J Immunol 116(5):1496-7. [PubMed: 1270804]  [MGI Ref ID J:5648]

Lyons BL; Smith RS; Hurd RE; Hawes NL; Burzenski LM; Nusinowitz S; Hasham MG; Chang B; Shultz LD. 2006. Deficiency of SHP-1 protein-tyrosine phosphatase in 'viable motheaten' mice results in retinal degeneration. Invest Ophthalmol Vis Sci 47(3):1201-9. [PubMed: 16505059]  [MGI Ref ID J:108375]

Martin A; Tsui HW; Tsui FW. 1999. SHP-1 variant proteins are absent in motheaten mice despite presence of splice variant transcripts with open reading frames. Mol Immunol 36(15-16):1029-41. [PubMed: 10698306]  [MGI Ref ID J:60297]

Mauldin IS; Tung KS; Lorenz UM. 2012. The tyrosine phosphatase SHP-1 dampens murine Th17 development. Blood 119(19):4419-29. [PubMed: 22438258]  [MGI Ref ID J:185170]

McCoy KL; Clagett J; Rosse C. 1985. Effects of the motheaten gene on murine B-cell production. Exp Hematol 13(6):554-9. [PubMed: 3873348]  [MGI Ref ID J:7856]

McCoy KL; Nielson K; Clagett J. 1984. Spontaneous production of colony-stimulating activity by splenic Mac-1 antigen-positive cells from autoimmune motheaten mice. J Immunol 132(1):272-6. [PubMed: 6361123]  [MGI Ref ID J:7274]

Mlinaric-Rascan I; Asa SL; Siminovitch KA. 1994. Increased expression of the stefin A cysteine proteinase inhibitor occurs in the myelomonocytic cell-infiltrated tissues of autoimmune motheaten mice. Am J Pathol 145(4):902-12. [PubMed: 7943179]  [MGI Ref ID J:20878]

Nakamura MC; Niemi EC; Fisher MJ; Shultz LD; Seaman WE; Ryan JC. 1997. Mouse Ly-49A interrupts early signaling events in natural killer cell cytotoxicity and functionally associates with the SHP-1 tyrosine phosphatase. J Exp Med 185(4):673-84. [PubMed: 9034146]  [MGI Ref ID J:38943]

Nakata K; Suzuki Y; Inoue T; Ra C; Yakura H; Mizuno K. 2011. Deficiency of SHP1 leads to sustained and increased ERK activation in mast cells, thereby inhibiting IL-3-dependent proliferation and cell death. Mol Immunol 48(4):472-80. [PubMed: 21044800]  [MGI Ref ID J:167059]

Nakata K; Yoshimaru T; Suzuki Y; Inoue T; Ra C; Yakura H; Mizuno K. 2008. Positive and negative regulation of high affinity IgE receptor signaling by Src homology region 2 domain-containing phosphatase 1. J Immunol 181(8):5414-24. [PubMed: 18832698]  [MGI Ref ID J:140765]

Napolitano A; Pittoni P; Beaudoin L; Lehuen A; Voehringer D; Macdonald HR; Dellabona P; Casorati G. 2013. Functional Education of Invariant NKT Cells by Dendritic Cell Tuning of SHP-1. J Immunol 190(7):3299-308. [PubMed: 23427253]  [MGI Ref ID J:194522]

Nesterovitch AB; Szanto S; Gonda A; Bardos T; Kis-Toth K; Adarichev VA; Olasz K; Ghassemi-Najad S; Hoffman MD; Tharp MD; Mikecz K; Glant TT. 2011. Spontaneous insertion of a b2 element in the ptpn6 gene drives a systemic autoinflammatory disease in mice resembling neutrophilic dermatosis in humans. Am J Pathol 178(4):1701-14. [PubMed: 21435452]  [MGI Ref ID J:169850]

Okenwa C; Kumar A; Rego D; Konarski Y; Nilchi L; Wright K; Kozlowski M. 2013. SHP-1-Pyk2-Src protein complex and p38 MAPK pathways independently regulate IL-10 production in lipopolysaccharide-stimulated macrophages. J Immunol 191(5):2589-603. [PubMed: 23904162]  [MGI Ref ID J:205817]

Paulson RF; Vesely S; Siminovitch KA; Bernstein A. 1996. Signalling by the W/Kit receptor tyrosine kinase is negatively regulated in vivo by the protein tyrosine phosphatase Shp1. Nat Genet 13(3):309-15. [PubMed: 8673130]  [MGI Ref ID J:34290]

Rego D; Kumar A; Nilchi L; Wright K; Huang S; Kozlowski M. 2011. IL-6 production is positively regulated by two distinct Src homology domain 2-containing tyrosine phosphatase-1 (SHP-1)-dependent CCAAT/enhancer-binding protein beta and NF-kappaB pathways and an SHP-1-independent NF-kappaB pathway in lipopolysaccharide-stimulated bone marrow-derived macrophages. J Immunol 186(9):5443-56. [PubMed: 21422245]  [MGI Ref ID J:172869]

Sathish JG; Dolton G; Leroy FG; Matthews RJ. 2007. Loss of Src homology region 2 domain-containing protein tyrosine phosphatase-1 increases CD8+ T cell-APC conjugate formation and is associated with enhanced in vivo CTL function. J Immunol 178(1):330-7. [PubMed: 17182570]  [MGI Ref ID J:141929]

Sathish JG; Walters J; Luo JC; Johnson KG; Leroy FG; Brennan P; Kim KP; Gygi SP; Neel BG; Matthews RJ. 2004. CD22 is a functional ligand for SH2 domain-containing protein-tyrosine phosphatase-1 in primary T cells. J Biol Chem 279(46):47783-91. [PubMed: 15364920]  [MGI Ref ID J:118518]

Scribner CL; Hansen CT; Klinman DM; Steinberg AD. 1987. The interaction of the xid and me genes. J Immunol 138(11):3611-7. [PubMed: 2884254]  [MGI Ref ID J:30994]

Shultz LD; Bailey CL; Coman DR. 1983. Hematopoietic stem cell function in motheaten mice. Exp Hematol 11(7):667-80. [PubMed: 6350031]  [MGI Ref ID J:7162]

Shultz LD; Green MC. 1976. Motheaten, an immunodeficient mutant of the mouse. II. Depressed immune competence and elevated serum immunoglobulins. J Immunol 116(4):936-43. [PubMed: 56406]  [MGI Ref ID J:5624]

Shultz LD; Rajan TV; Greiner DL. 1997. Severe defects in immunity and hematopoiesis caused by SHP-1 protein-tyrosine-phosphatase deficiency. Trends Biotechnol 15(8):302-7. [PubMed: 9263478]  [MGI Ref ID J:42157]

Shultz LD; Schweitzer PA; Rajan TV; Yi T; Ihle JN; Matthews RJ; Thomas ML; Beier DR. 1993. Mutations at the murine motheaten locus are within the hematopoietic cell protein-tyrosine phosphatase (Hcph) gene. Cell 73(7):1445-54. [PubMed: 8324828]  [MGI Ref ID J:14935]

Sidman CL; Shultz LD; Unanue ER. 1978. The mouse mutant motheaten. II. Functional studies of the immune system. J Immunol 121(6):2399-404. [PubMed: 363947]  [MGI Ref ID J:6065]

Sundberg JP (ed.). 1994. Handbook of Mouse Mutations with Skin and Hair Abnormalities: Animal Models and Biomedical Tools. In: Handbook of Mouse Mutations with Skin and Hair Abnormalities: Animal Models and Biomedical Tools. CRC Press, Boca Raton.  [MGI Ref ID J:30359]

Takeoka Y; Chen SY; Boyd RL; Tsuneyama K; Taguchi N; Morita S; Yago H; Suehiro S; Ansari AA; Shultz LD; Gershwin ME. 1997. A comparative analysis of the murine thymic microenvironment in normal, autoimmune, and immunodeficiency states. Dev Immunol 5(2):79-89. [PubMed: 9587708]  [MGI Ref ID J:44504]

Tsui FW; Tsui HW. 1994. Molecular basis of the motheaten phenotype. Immunol Rev 138:185-206. [PubMed: 8070815]  [MGI Ref ID J:18549]

Tsui HW; Siminovitch KA; de Souza L; Tsui FW. 1993. Motheaten and viable motheaten mice have mutations in the haematopoietic cell phosphatase gene. Nat Genet 4(2):124-9. [PubMed: 8348149]  [MGI Ref ID J:11892]

Umeda S; Beamer WG; Takagi K; Naito M; Hayashi S; Yonemitsu H; Yi T; Shultz LD. 1999. Deficiency of SHP-1 protein-tyrosine phosphatase activity results in heightened osteoclast function and decreased bone density. Am J Pathol 155(1):223-33. [PubMed: 10393854]  [MGI Ref ID J:108187]

Ward JM. 1978. Pulmonary pathology of the motheaten mouse. Vet Pathol 15(2):170-8. [PubMed: 664185]  [MGI Ref ID J:5999]

Wishcamper CA; Coffin JD; Lurie DI. 2001. Lack of the protein tyrosine phosphatase SHP-1 results in decreased numbers of glia within the motheaten (me/me) mouse brain. J Comp Neurol 441(2):118-33. [PubMed: 11745639]  [MGI Ref ID J:72655]

Yang W; Mckenna SD; Jiao H; Tabrizi M; Lynes MA; Shultz LD; Yi T. 1998. SHP-1 deficiency in B-lineage cells is associated with heightened lyn protein expression and increased lyn kinase activity. Exp Hematol 26(12):1126-32. [PubMed: 9808051]  [MGI Ref ID J:51142]

Zhao J; Brooks DM; Lurie DI. 2006. Lipopolysaccharide-activated SHP-1-deficient motheaten microglia release increased nitric oxide, TNF-alpha, and IL-1beta. Glia 53(3):304-12. [PubMed: 16265671]  [MGI Ref ID J:156147]

Zhao J; Lurie DI. 2004. Cochlear ablation in mice lacking SHP-1 results in an extended period of cell death of anteroventral cochlear nucleus neurons. Hear Res 189(1-2):63-75. [PubMed: 14987753]  [MGI Ref ID J:88807]

a related

Baba K; Sakakibara S; Setsu T; Terashima T. 2007. The superficial layers of the superior colliculus are cytoarchitectually and myeloarchitectually disorganized in the reelin-deficient mouse, reeler. Brain Res 1140:205-15. [PubMed: 17173877]  [MGI Ref ID J:120267]

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Bultman SJ; Klebig ML; Michaud EJ; Sweet HO; Davisson MT; Woychik RP. 1994. Molecular analysis of reverse mutations from nonagouti (a) to black-and-tan (a(t)) and white-bellied agouti (Aw) reveals alternative forms of agouti transcripts. Genes Dev 8(4):481-90. [PubMed: 8125260]  [MGI Ref ID J:16984]

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Butler AE; Janson J; Soeller WC; Butler PC. 2003. Increased beta-cell apoptosis prevents adaptive increase in beta-cell mass in mouse model of type 2 diabetes: evidence for role of islet amyloid formation rather than direct action of amyloid. Diabetes 52(9):2304-14. [PubMed: 12941770]  [MGI Ref ID J:132530]

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Dunn LC. 1945. A New Eye Color Mutant in the Mouse with Asymmetrical Expression. Proc Natl Acad Sci U S A 31(11):343-6. [PubMed: 16578176]  [MGI Ref ID J:13122]

Dunn LC; Macdowell EC; Lebedeff GA. 1937. Studies on Spotting Patterns III. Interaction between Genes Affecting White Spotting and Those Affecting Color in the House Mouse. Genetics 22(2):307-18. [PubMed: 17246842]  [MGI Ref ID J:12954]

Enshell-Seijffers D; Lindon C; Morgan BA. 2008. The serine protease Corin is a novel modifier of the Agouti pathway. Development 135(2):217-25. [PubMed: 18057101]  [MGI Ref ID J:130426]

Feuerer M; Herrero L; Cipolletta D; Naaz A; Wong J; Nayer A; Lee J; Goldfine AB; Benoist C; Shoelson S; Mathis D. 2009. Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters. Nat Med 15(8):930-9. [PubMed: 19633656]  [MGI Ref ID J:152186]

Fujimoto W; Shiuchi T; Miki T; Minokoshi Y; Takahashi Y; Takeuchi A; Kimura K; Saito M; Iwanaga T; Seino S. 2007. Dmbx1 is essential in agouti-related protein action. Proc Natl Acad Sci U S A 104(39):15514-9. [PubMed: 17873059]  [MGI Ref ID J:125193]

Gajewska M; Krysiak E; Wirth-Dziecialowska E. 2010. New coat color mutation mapped in distal part MMU10 MGI Direct Data Submission :.  [MGI Ref ID J:162146]

Galbraith DB; Arceci RJ. 1974. Melanocyte populations of yellow and black hair bulbs in the mouse. J Hered 65(6):381-2. [PubMed: 4448905]  [MGI Ref ID J:5512]

Galbraith DB; Patrignani AM. 1976. Sulfhydryl compounds in melanocytes of yellow (Ay/a), nonagouti (a/a), and agouti (A/A) mice. Genetics 84(3):587-91. [PubMed: 1001879]  [MGI Ref ID J:5737]

Galbraith DB; Wolff GL; Brewer NL. 1980. Hair pigment patterns in different integumental environments of the mouse. Influence of the agouti suppressor (A<s>) mutation on expression of agouti locus alleles. J Hered 71:229-234.  [MGI Ref ID J:12033]

Galbraith DB; Wolff GL; Brewer NL. 1979. Tissue microenvironment and the genetic control of hair pigment patterns in mice Dev Genet 1(2):167-179.  [MGI Ref ID J:156092]

Geschwind II; Huseby RA; Nishioka R. 1972. The effect of melanocyte-stimulating hormone on coat color in the mouse. Recent Prog Horm Res 28:91-130. [PubMed: 4631622]  [MGI Ref ID J:5324]

Granholm DE; Reese RN; Granholm NH. 1996. Agouti alleles alter cysteine and glutathione concentrations in hair follicles and serum of mice (A y/a, A wJ/A wJ, and a/a). J Invest Dermatol 106(3):559-63. [PubMed: 8648194]  [MGI Ref ID J:32132]

Gruneberg H. 1952. . In: The Genetics of the Mouse. Martinus Nijhoff, The Hague.  [MGI Ref ID J:30758]

Heaney JD; Michelson MV; Youngren KK; Lam MY; Nadeau JH. 2009. Deletion of eIF2beta suppresses testicular cancer incidence and causes recessive lethality in agouti-yellow mice. Hum Mol Genet 18(8):1395-404. [PubMed: 19168544]  [MGI Ref ID J:146879]

Hearing VJ; Phillips P; Lutzner MA. 1973. The fine structure of melanogenesis in coat color mutants of the mouse. J Ultrastruct Res 43(1):88-106. [PubMed: 4634048]  [MGI Ref ID J:5346]

Hustad CM; Perry WL; Siracusa LD; Rasberry C; Cobb L; Cattanach BM; Kovatch R; Copeland NG; Jenkins NA. 1995. Molecular genetic characterization of six recessive viable alleles of the mouse agouti locus. Genetics 140(1):255-65. [PubMed: 7635290]  [MGI Ref ID J:24934]

Iwatsuka H; Shino A; Suzuoki Z. 1970. General survey of diabetic features of yellow KK mice. Endocrinol Jpn 17(1):23-35. [PubMed: 5468422]  [MGI Ref ID J:26460]

Jackson IJ; Budd PS; Keighren M; McKie L. 2007. Humanized MC1R transgenic mice reveal human specific receptor function. Hum Mol Genet 16(19):2341-8. [PubMed: 17652101]  [MGI Ref ID J:129904]

Kaelin CB; Xu X; Hong LZ; David VA; McGowan KA; Schmidt-Kuntzel A; Roelke ME; Pino J; Pontius J; Cooper GM; Manuel H; Swanson WF; Marker L; Harper CK; van Dyk A; Yue B; Mullikin JC; Warren WC; Eizirik E; Kos L; O'Brien SJ; Barsh GS; Menotti-Raymond M. 2012. Specifying and sustaining pigmentation patterns in domestic and wild cats. Science 337(6101):1536-41. [PubMed: 22997338]  [MGI Ref ID J:188277]

Kaminen-Ahola N; Ahola A; Maga M; Mallitt KA; Fahey P; Cox TC; Whitelaw E; Chong S. 2010. Maternal ethanol consumption alters the epigenotype and the phenotype of offspring in a mouse model. PLoS Genet 6(1):e1000811. [PubMed: 20084100]  [MGI Ref ID J:156866]

Kappenman KE; Dvoracek MA; Harvison GA; Fuller BB; Granholm NH. 1992. Tyrosinase abundance and activity in murine hairbulb melanocytes of agouti mutants (C57BL/6J-a/a, Ay/a, and AwJ/AwJ). Pigment Cell Res Suppl 2:79-83. [PubMed: 1409442]  [MGI Ref ID J:1295]

Knisely AS; Gasser DL; Silvers WK. 1975. Expression in organ culture of agouti locus genes of the mouse. Genetics 79(3):471-5. [PubMed: 1126628]  [MGI Ref ID J:5533]

Lamoreux ML; Wakamatsu K; Ito S. 2001. Interaction of major coat color gene functions in mice as studied by chemical analysis of eumelanin and pheomelanin. Pigment Cell Res 14(1):23-31. [PubMed: 11277491]  [MGI Ref ID J:103803]

Lane PW. 1989. Mottled agouti-J (am-J) Mouse News Lett 84:89.  [MGI Ref ID J:16570]

Leamy LJ; Hrubant HE. 1971. Effects of alleles at the agouti locus on odontometric traits in the C57BL-6 strain of house mice. Genetics 67(1):87-96. [PubMed: 5556294]  [MGI Ref ID J:16571]

Loosli R. 1963. Tanoid--a new agouti mutant in the mouse. J Hered 54:26-29.  [MGI Ref ID J:13082]

Markert CL; Silvers WK. 1956. The Effects of Genotype and Cell Environment on Melanoblast Differentiation in the House Mouse. Genetics 41(3):429-50. [PubMed: 17247639]  [MGI Ref ID J:12970]

Martin NM; Houston PA; Patterson M; Sajedi A; Carmignac DF; Ghatei MA; Bloom SR; Small CJ. 2006. Abnormalities of the somatotrophic axis in the obese agouti mouse. Int J Obes (Lond) 30(3):430-8. [PubMed: 16172617]  [MGI Ref ID J:151302]

Martinez HG; Quinones MP; Jimenez F; Estrada CA; Clark K; Muscogiuri G; Sorice G; Musi N; Reddick RL; Ahuja SS. 2011. Critical role of chemokine (C-C motif) receptor 2 (CCR2) in the KKAy + Apoe -/- mouse model of the metabolic syndrome. Diabetologia 54(10):2660-8. [PubMed: 21779871]  [MGI Ref ID J:177084]

Mayer TC; Fishbane JL. 1972. Mesoderm-ectoderm interaction in the production of the agouti pigmentation pattern in mice. Genetics 71(2):297-303. [PubMed: 4558326]  [MGI Ref ID J:5288]

Miller MW; Duhl DM; Vrieling H; Cordes SP; Ollmann MM; Winkes BM; Barsh GS. 1993. Cloning of the mouse agouti gene predicts a secreted protein ubiquitously expressed in mice carrying the lethal yellow mutation. Genes Dev 7(3):454-67. [PubMed: 8449404]  [MGI Ref ID J:4186]

Miyazaki M; Sampath H; Liu X; Flowers MT; Chu K; Dobrzyn A; Ntambi JM. 2009. Stearoyl-CoA desaturase-1 deficiency attenuates obesity and insulin resistance in leptin-resistant obese mice. Biochem Biophys Res Commun 380(4):818-22. [PubMed: 19338759]  [MGI Ref ID J:147343]

Monroe DG; Wipf LP; Diggins MR; Matthees DP; Granholm NH. 1998. Agouti-related maturation and tissue distribution of alpha-Melanocyte Stimulating Hormone in wild-type (AwJ/AwJ) and mutant (Ay/a,a/a) mice. Pigment Cell Res 11(5):310-3. [PubMed: 9877102]  [MGI Ref ID J:52183]

Moore KJ; Swing DA; Copeland NG; Jenkins NA. 1990. Interaction of the murine dilute suppressor gene (dsu) with fourteen coat color mutations [published erratum appears in Genetics 1990 Sep;126(1):285] Genetics 125(2):421-30. [PubMed: 2379821]  [MGI Ref ID J:29467]

Moyer FH. 1966. Genetic variations in the fine structure and ontogeny of mouse melanin granules. Am Zool 6(1):43-66. [PubMed: 5902512]  [MGI Ref ID J:5001]

Novak EK; Gautam R; Reddington M; Collinson LM; Copeland NG; Jenkins NA; McGarry MP; Swank RT. 2002. The regulation of platelet-dense granules by Rab27a in the ashen mouse, a model of Hermansky-Pudlak and Griscelli syndromes, is granule-specific and dependent on genetic background. Blood 100(1):128-35. [PubMed: 12070017]  [MGI Ref ID J:77395]

Novak EK; Wieland F; Jahreis GP; Swank RT. 1980. Altered secretion of kidney lysosomal enzymes in the mouse pigment mutants ruby-eye, ruby-eye-2-J, and maroon. Biochem Genet 18(5-6):549-61. [PubMed: 6776948]  [MGI Ref ID J:6422]

Nuotio-Antar AM; Hachey DL; Hasty AH. 2007. Carbenoxolone treatment attenuates symptoms of metabolic syndrome and atherogenesis in obese, hyperlipidemic mice. Am J Physiol Endocrinol Metab 293(6):E1517-28. [PubMed: 17878220]  [MGI Ref ID J:145108]

Papacleovoulou G; Abu-Hayyeh S; Nikolopoulou E; Briz O; Owen BM; Nikolova V; Ovadia C; Huang X; Vaarasmaki M; Baumann M; Jansen E; Albrecht C; Jarvelin MR; Marin JJ; Knisely AS; Williamson C. 2013. Maternal cholestasis during pregnancy programs metabolic disease in offspring. J Clin Invest 123(7):3172-81. [PubMed: 23934127]  [MGI Ref ID J:201610]

Pettitt SJ; Liang Q; Rairdan XY; Moran JL; Prosser HM; Beier DR; Lloyd KC; Bradley A; Skarnes WC. 2009. Agouti C57BL/6N embryonic stem cells for mouse genetic resources. Nat Methods :. [PubMed: 19525957]  [MGI Ref ID J:149352]

Poole TW. 1975. Dermal-epidermal interactions and the action of alleles at the agouti locus in the mouse. Dev Biol 42(2):203-10. [PubMed: 1090472]  [MGI Ref ID J:5519]

Poole TW. 1982. The agouti suppressor (As) coat color mutation in mice: developmental effects on the expression of agouti locus alleles. J Exp Zool 220(1):57-64. [PubMed: 7077265]  [MGI Ref ID J:6763]

Quevedo WC Jr.; Chase HB. 1958. An analysis of the light mutation of coat color in mice. J Morphol 102:329-345.  [MGI Ref ID J:13094]

Quevedo WC Jr; Holstein TJ. 1992. The shift from physiological genetics to molecular genetics in the study of mouse tyrosinase. Pigment Cell Res Suppl 2:57-60. [PubMed: 1409439]  [MGI Ref ID J:3852]

RUSSELL ES. 1949. A quantitative histological study of the pigment found in the coat-color mutants of the house mouse; interdependence among the variable granule attributes. Genetics 34(2):133-45. [PubMed: 18117146]  [MGI Ref ID J:148461]

Rakyan VK; Chong S; Champ ME; Cuthbert PC; Morgan HD; Luu KV; Whitelaw E. 2003. Transgenerational inheritance of epigenetic states at the murine Axin(Fu) allele occurs after maternal and paternal transmission. Proc Natl Acad Sci U S A 100(5):2538-43. [PubMed: 12601169]  [MGI Ref ID J:82396]

Rice RH; Bradshaw KM; Durbin-Johnson BP; Rocke DM; Eigenheer RA; Phinney BS; Sundberg JP. 2012. Differentiating inbred mouse strains from each other and those with single gene mutations using hair proteomics. PLoS One 7(12):e51956. [PubMed: 23251662]  [MGI Ref ID J:195664]

Rosenfeld CS; Sieli PT; Warzak DA; Ellersieck MR; Pennington KA; Roberts RM. 2013. Maternal exposure to bisphenol A and genistein has minimal effect on A(vy)/a offspring coat color but favors birth of agouti over nonagouti mice. Proc Natl Acad Sci U S A 110(2):537-42. [PubMed: 23267115]  [MGI Ref ID J:193279]

Russell ES. 1948. A Quantitative Histological Study of the Pigment Found in the Coat Color Mutants of the House Mouse. II. Estimates of the Total Volume of Pigment. Genetics 33(3):228-36. [PubMed: 17247280]  [MGI Ref ID J:148462]

Russell ES. 1946. A Quantitative Histological Study of the Pigment Found in the Coat-Color Mutants of the House Mouse. I. Variable Attributes of the Pigment Granules. Genetics 31(3):327-46. [PubMed: 17247200]  [MGI Ref ID J:148463]

Russell ES. 1949. A Quantitative Histological Study of the Pigment Found in the Coat-Color Mutants of the House Mouse. IV. the Nature of the Effects of Genic Substitution in Five Major Allelic Series. Genetics 34(2):146-66. [PubMed: 17247308]  [MGI Ref ID J:12958]

Russell LB. 1964. Genetic and Functional Mosaicism in the Mouse. In: The Role of the Chromosomes in Development. Academic Press, New York.  [MGI Ref ID J:29504]

Russell LB; Cupp McDaniel MN; Woodiel FN,. 1963. Crossing over within the a "locus" of the mouse Genetics 48:907 Abstr.  [MGI Ref ID J:174047]

SILVERS WK. 1958. An experimental approach to action of genes at the agouti locus in the mouse. III. Transplants of newborn Aw-, A-and at-skin to Ay-, Aw-, A-and aa hosts. J Exp Zool 137(1):189-96. [PubMed: 13563791]  [MGI Ref ID J:13013]

Sakurai T; Ochiai H; Takeuchi T. 1975. Ultrastructural change of melanosomes associated with agouti pattern formation in mouse hair. Dev Biol 47(2):466-71. [PubMed: 1204945]  [MGI Ref ID J:5606]

Silvers WK. 1979. The Coat Colors of Mice; A Model for Mammalian Gene Action and Interaction. In: The Coat Colors of Mice. Springer-Verlag, New York.  [MGI Ref ID J:78801]

Soeller WC; Janson J; Hart SE; Parker JC; Carty MD; Stevenson RW; Kreutter DK; Butler PC. 1998. Islet amyloid-associated diabetes in obese A(vy)/a mice expressing human islet amyloid polypeptide. Diabetes 47(5):743-50. [PubMed: 9588445]  [MGI Ref ID J:133694]

Suto J. 2008. Coincidence of loci for glucosuria and obesity in type 2 diabetes-prone KK-Ay mice. Med Sci Monit 14(2):CR65-74. [PubMed: 18227763]  [MGI Ref ID J:131439]

Suto J. 2009. Identification of multiple quantitative trait loci affecting the size and shape of the mandible in mice. Mamm Genome 20(1):1-13. [PubMed: 19067046]  [MGI Ref ID J:143893]

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Suwa A; Yoshino M; Yamazaki C; Naitou M; Fujikawa R; Matsumoto S; Kurama T; Shimokawa T; Aramori I. 2010. RMI1 deficiency in mice protects from diet and genetic-induced obesity. FEBS J 277(3):677-86. [PubMed: 20050919]  [MGI Ref ID J:168271]

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Health & husbandry

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Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Pricing and Purchasing

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Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $2450.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery of Strains Needing Progeny Testing
    At least two untested males and two untested females (two pairs) will be recovered (eight or more mice is typical). The total number of animals provided, their gender and genotype will vary. Untested animals typically are available to ship between 13 and 16 weeks from the date of your order. If the first recovery attempt is unsuccessful, a second recovery will be done, extending the overall recovery time to approximately 25 weeks. Progeny testing is required to identify the genotype of mice of this strain, as a genotyping assay is not available. This type of testing involves breeding the recovered animals and assessing the phenotype of the offspring in order to identify animals carrying the mutation of interest. We can perform the progeny testing for you as a service or we can ship all recovered animals to you for progeny testing at your facility. If you perform the progeny testing, there is NO guarantee that a carrier will be identified. If we perform progeny testing as a service, additional breeding time will be required. In this case, when a male and female (one pair) are identified that carry the mutation, they and their offspring will be shipped. Delivery time for strains requiring progeny testing often exceeds 25 weeks and may take 12 months or more due to the difficulties in breeding some strains. The progeny testing cost is in addition to the recovery cost and is based on the number of boxes used and the time taken to produce the mice identified as carrying the mutation.
    Please note that identified pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation.

    Please contact Customer Service for more information on the cost of progeny testing for a strain: Tel: 1-800-422-6423 or 1-207-288-5845 (from any location). The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
    Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $3185.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery of Strains Needing Progeny Testing
    At least two untested males and two untested females (two pairs) will be recovered (eight or more mice is typical). The total number of animals provided, their gender and genotype will vary. Untested animals typically are available to ship between 13 and 16 weeks from the date of your order. If the first recovery attempt is unsuccessful, a second recovery will be done, extending the overall recovery time to approximately 25 weeks. Progeny testing is required to identify the genotype of mice of this strain, as a genotyping assay is not available. This type of testing involves breeding the recovered animals and assessing the phenotype of the offspring in order to identify animals carrying the mutation of interest. We can perform the progeny testing for you as a service or we can ship all recovered animals to you for progeny testing at your facility. If you perform the progeny testing, there is NO guarantee that a carrier will be identified. If we perform progeny testing as a service, additional breeding time will be required. In this case, when a male and female (one pair) are identified that carry the mutation, they and their offspring will be shipped. Delivery time for strains requiring progeny testing often exceeds 25 weeks and may take 12 months or more due to the difficulties in breeding some strains. The progeny testing cost is in addition to the recovery cost and is based on the number of boxes used and the time taken to produce the mice identified as carrying the mutation.
    Please note that identified pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation.

    Please contact Customer Service for more information on the cost of progeny testing for a strain: Tel: 1-800-422-6423 or 1-207-288-5845 (from any location). The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
    Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

General Supply Notes

  • View the complete collection of spontaneous mutants in the Mouse Mutant Resource.

Control Information

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  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

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The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


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