Strain Name:

B6C3Fe a/a-Largemyd/J

Stock Number:

000226

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Availability:

Cryopreserved - Ready for recovery

Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Former Names B6C3Fe-a/a-Largemyd/+    (Changed: 15-DEC-04 )
Type Mutant Stock; Spontaneous Mutation;
Additional information on Genetically Engineered and Mutant Mice.
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Specieslaboratory mouse

Development
The myodystrophy mutation, Largemyd, arose spontaneously at the Jackson Laboratory in the lethal spotting strain (LS/LeJ) in 1963. The first affected male was outcrossed to a C57BL/6J female. Matings of a homozygote by heterozygote were carried out as often as possible or as heterozygous pairs. At F43 in 1977 a Largemyd homozygote was mated to a B6C3Fe-a/a hybrid and the strain was maintained by the cross intercross system to the hybrid. When this strain was at N19, it was cryopreserved by mating heterozygous females to heterozygous males to generate embryos.

Related Strains

Strains carrying   Largemyd allele
018305   MYD/Le-Largemyd/J
000300   MYD/Le-Os +/+ Largemyd/J
View Strains carrying   Largemyd     (2 strains)

Strains carrying   a allele
003879   B10;TFLe-a/a T Itpr3tf/+ Itpr3tf/J
001538   B6 x B6C3Sn a/A-T(1;9)27H/J
000916   B6 x B6C3Sn a/A-T(5;12)31H/J
000602   B6 x B6C3Sn a/A-T(8;16)17H/J
000618   B6 x FSB/GnEi a/a Ctslfs/J
000577   B6 x STOCK a Oca2p Hps5ru2 Ednrbs/J
000601   B6 x STOCK a/a T(7;18)50H/J
000592   B6 x STOCK T(2;4)13H a/J
014608   B6;129S1-a Kitlsl-24J/GrsrJ
000231   B6;C3Fe a/a-Csf1op/J
000785   B6;D2-a Ces1ce/EiJ
000604   B6C3 a/A-T(10;13)199H +/+ Lystbg-J/J or Lystbg-2J/J
001750   B6C3Fe a/a-Eif3cXs-J/J
002807   B6C3Fe a/a-Meox2fla/J
000506   B6C3Fe a/a-Qkqk-v/J
000224   B6C3Fe a/a-Scyl1mdf/J
003020   B6C3Fe a/a-Zdhhc21dep/J
001037   B6C3Fe a/a-Agtpbp1pcd/J
000221   B6C3Fe a/a-Alx4lst-J/J
002062   B6C3Fe a/a-Atp7aMo-8J/J
001756   B6C3Fe a/a-Cacng2stg/J
001815   B6C3Fe a/a-Col1a2oim/J
000209   B6C3Fe a/a-Dh/J
000211   B6C3Fe a/a-Dstdt-J/J
000210   B6C3Fe a/a-Edardl-J/J
000207   B6C3Fe a/a-Edaraddcr/J
000182   B6C3Fe a/a-Eef1a2wst/J
001278   B6C3Fe a/a-Glra1spd/J
000241   B6C3Fe a/a-Glrbspa/J
002875   B6C3Fe a/a-Hoxd13spdh/J
000304   B6C3Fe a/a-Krt71Ca Scn8amed-J/J
000636   B6C3Fe a/a-Lmx1adr-J/J
001280   B6C3Fe a/a-Lse/J
001573   B6C3Fe a/a-MitfMi/J
001035   B6C3Fe a/a-Napahyh/J
000181   B6C3Fe a/a-Otogtwt/J
000278   B6C3Fe a/a-Papss2bm Hps1ep Hps6ru/J
000205   B6C3Fe a/a-Papss2bm/J
002078   B6C3Fe a/a-Pcdh15av-2J/J
000246   B6C3Fe a/a-Pitpnavb/J
001430   B6C3Fe a/a-Ptch1mes/J
000235   B6C3Fe a/a-Relnrl/J
000237   B6C3Fe a/a-Rorasg/J
000290   B6C3Fe a/a-Sox10Dom/J
000230   B6C3Fe a/a-Tcirg1oc/J
003612   B6C3Fe a/a-Trak1hyrt/J
001512   B6C3Fe a/a-Ttnmdm/J
001607   B6C3Fe a/a-Unc5crcm/J
000005   B6C3Fe a/a-Wc/J
000243   B6C3Fe a/a-Wnt1sw/J
000248   B6C3Fe a/a-Xpl/J
000624   B6C3Fe a/a-anx/J
008044   B6C3Fe a/a-bpck/J
002018   B6C3Fe a/a-din/J
002339   B6C3Fe a/a-nma/J
000240   B6C3Fe a/a-soc/J
000063   B6C3Fe a/a-sy/J
001055   B6C3Fe a/a-tip/J
000245   B6C3Fe a/a-tn/J
000296   B6C3Fe-a/a Hoxa13Hd Mcoln3Va-J/J
000019   B6C3Fe-a/a-Itpr1opt/J
001022   B6C3FeF1/J a/a
006450   B6EiC3 a/A-Vss/GrsrJ
000971   B6EiC3 a/A-Och/J
000551   B6EiC3 a/A-Tbx15de-H/J
000557   B6EiC3-+ a/LnpUl A/J
000503   B6EiC3Sn a/A-Gy/J
001811   B6EiC3Sn a/A-Otcspf-ash/J
002343   B6EiC3Sn a/A-Otcspf/J
000391   B6EiC3Sn a/A-Pax6Sey-Dey/J
001923   B6EiC3Sn a/A-Ts(417)2Lws TimT(4;17)3Lws/J
000225   C3FeLe.B6 a/a-Ptpn6me/J
000198   C3FeLe.B6-a/J
000291   C3FeLe.Cg-a/a Hm KitlSl Krt71Ca-J/J
001886   C3HeB/FeJLe a/a-gnd/J
000584   C57BL/6J-+ T(1;2)5Ca/a +/J
000670   DBA/1J
000671   DBA/2J
001057   HPT/LeJ
000260   JGBF/LeJ
000265   MY/HuLeJ
000308   SSL/LeJ
000994   STOCK a Myo5ad Mregdsu/J
000064   STOCK a Tyrp1b Pmelsi/J
002238   STOCK a Tyrp1b shmy/J
001433   STOCK a skt/J
000579   STOCK a tp/J
000319   STOCK a us/J
002648   STOCK a/a Cln6nclf/J
000317   STOCK a/a Egfrwa2/J
000302   STOCK a/a MitfMi-wh +/+ Itpr1opt/J
000286   STOCK a/a Myo5ad fd/+ +/J
000281   STOCK a/a Tmem79ma Flgft/J
000206   STOCK a/a Tyrc-h/J
001432   STOCK a/a Tyrp1b Ndc1sks/Tyrp1b +/J
000312   STOCK stb + a/+ Fignfi a/J
000596   STOCK T(2;11)30H/+ x AEJ-a Gdf5bp-H/J or A/J-a Gdf5bp-J/J
000970   STOCK T(2;16)28H A/T(2;16)28H a/J
000590   STOCK T(2;4)1Sn a/J
000594   STOCK T(2;8)26H a/T(2;8)26H a Tyrp1+/Tyrp1b/J
000623   TR/DiEiJ
View Strains carrying   a     (101 strains)

Strains carrying other alleles of Large
005350   B6.CAST(Cg)-Largevls/Pjn
002491   B6.Cg-Largeenr-Tg(MpbReg)36Pop/J
008581   STOCK Largemyd-3J/GrsrJ
View Strains carrying other alleles of Large     (3 strains)

Strains carrying other alleles of a
002655   Mus pahari/EiJ
000251   AEJ.Cg-ae +/a Gdf5bp-H/J
000202   AEJ/Gn-bd/J
000199   AEJ/GnLeJ
000433   B10.C-H3c H13? A/(28NX)SnJ
000427   B10.CE-H13b Aw/(30NX)SnJ
000423   B10.KR-H13? A/SnJ
000420   B10.LP-H13b Aw/Sn
000477   B10.PA-Bloc1s6pa H3e at/SnJ
000419   B10.UW-H3b we Pax1un at/SnJ
000593   B6 x B6CBCa Aw-J/A-Grid2Lc T(2;6)7Ca MitfMi-wh/J
000502   B6 x B6CBCa Aw-J/A-Myo5aflr Gnb5flr/J
000599   B6 x B6CBCa Aw-J/A-T(5;13)264Ca KitW-v/J
002083   B6 x B6EiC3 a/A-T(7;16)235Dn/J
000507   B6 x B6EiC3 a/A-Otcspf/J
003759   B6 x B6EiC3Sn a/A-T(10;16)232Dn/J
002071   B6 x B6EiC3Sn a/A-T(11;17)202Dn/J
002113   B6 x B6EiC3Sn a/A-T(11A2;16B3)238Dn/J
002068   B6 x B6EiC3Sn a/A-T(11B1;16B5)233Dn/J
002069   B6 x B6EiC3Sn a/A-T(14E4or5;16B5)225Dn/J
001926   B6 x B6EiC3Sn a/A-T(15;16)198Dn/J
001832   B6 x B6EiC3Sn a/A-T(15E;16B1)60Dn/J
003758   B6 x B6EiC3Sn a/A-T(16C3-4;17A2)65Dn/J
001833   B6 x B6EiC3Sn a/A-T(1C2;16C3)45Dn/J
001903   B6 x B6EiC3Sn a/A-T(6F;18C)57Dn/J
001535   B6 x B6EiC3Sn a/A-T(8A4;12D1)69Dn/J
001831   B6 x B6EiC3Sn a/A-T(8C3;16B5)164Dn/J
002016   B6(Cg)-Aw-J EdaTa-6J Chr YB6-Sxr/EiJ
000600   B6-Gpi1b x B6CBCa Aw-J/A-T(7;15)9H Gpi1a/J
000769   B6.C/(HZ18)By-at-44J/J
000203   B6.C3-Aiy/a/J
000017   B6.C3-Avy/J
001572   B6.C3-am-J/J
000628   B6.CE-A Amy1b Amy2a5b/J
001809   B6.Cg-Aw-J EdaTa-6J +/+ ArTfm/J
000552   B6.Cg-Aw-J EdaTa-6J Sxr
001730   B6.Cg-Aw-J EdaTa-6J Sxrb Hya-/J
000841   B6.Cg-Aw-J EdaTa-By/J
000021   B6.Cg-Ay/J
100409   B6129PF1/J-Aw-J/Aw
004200   B6;CBACa Aw-J/A-Npr2cn-2J/GrsrJ
000505   B6C3 Aw-J/A-Bloc1s5mu/J
000604   B6C3 a/A-T(10;13)199H +/+ Lystbg-J/J or Lystbg-2J/J
000065   B6C3Fe a/a-we Pax1un at/J
003301   B6C3FeF1 a/A-Eya1bor/J
000314   B6CBACa Aw-J/A-EdaTa/J-XO
000501   B6CBACa Aw-J/A-Aifm1Hq/J
001046   B6CBACa Aw-J/A-Grid2Lc/J
000500   B6CBACa Aw-J/A-Gs/J
002703   B6CBACa Aw-J/A-Hydinhy3/J
000247   B6CBACa Aw-J/A-Kcnj6wv/J
000287   B6CBACa Aw-J/A-Plp1jp EdaTa/J
000515   B6CBACa Aw-J/A-SfnEr/J
000242   B6CBACa Aw-J/A-spc/J
000288   B6CBACa Aw-J/A-we a Mafbkr/J
001201   B6CBACaF1/J-Aw-J/A
006450   B6EiC3 a/A-Vss/GrsrJ
000557   B6EiC3-+ a/LnpUl A/J
000504   B6EiC3Sn a/A-Cacnb4lh/J
000553   B6EiC3Sn a/A-Egfrwa2 Wnt3avt/J
001811   B6EiC3Sn a/A-Otcspf-ash/J
002343   B6EiC3Sn a/A-Otcspf/J
001923   B6EiC3Sn a/A-Ts(417)2Lws TimT(4;17)3Lws/J
001875   B6EiC3SnF1/J
000638   C3FeB6 A/Aw-J-Sptbn4qv-J/J
000200   C3FeB6 A/Aw-J-Ankank/J
001203   C3FeB6F1/J A/Aw-J
001272   C3H/HeSnJ-Ahvy/J
000099   C3HeB/FeJ-Avy/J
000338   C57BL/6J Aw-J-EdaTa-6J/J
000258   C57BL/6J-Ai/a/J
000774   C57BL/6J-Asy/a/J
000569   C57BL/6J-Aw-J-EdaTa +/+ ArTfm/J
000051   C57BL/6J-Aw-J/J
000055   C57BL/6J-at-33J/J
000070   C57BL/6J-atd/J
002468   KK.Cg-Ay/J
000262   LS/LeJ
000283   LT.CAST-A/J
001759   STOCK A Tyrc Sha/J
001427   STOCK Aw us/J
001145   WSB/EiJ
View Strains carrying other alleles of a     (82 strains)

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Model with phenotypic similarity to human disease where etiologies involve orthologs. Human genes are associated with this disease. Orthologs of those genes appear in the mouse genotype(s).
Muscular Dystrophy-Dystroglycanopathy (congenital with Brain and Eye Anomalies), Type A, 6; MDDGA6
- Model with phenotypic similarity to human disease where etiologies are distinct. Human genes are associated with this disease. Orthologs of these genes do not appear in the mouse genotype(s).
Facioscapulohumeral Muscular Dystrophy 1; FSHD1
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested.
Muscular Dystrophy-Dystroglycanopathy (congenital with Brain and Eye Anomalies), Type A, 1; MDDGA1   (LARGE)
Muscular Dystrophy-Dystroglycanopathy (congenital with Mental Retardation), Type B, 6; MDDGB6   (LARGE)
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

Largemyd/Large+

        B6C3Fe a/a-Largemyd/J
  • behavior/neurological phenotype
  • limb grasping
    • some aging animals exhibit atypical hindlimb posture and movements when lifted by the tail   (MGI Ref ID J:27793)

Largemyd/Largemyd

        B6C3Fe a/a-Largemyd/J
  • muscle phenotype
  • abnormal myocardial fiber morphology
    • mutants exhibit focal patches of cardiac myocyte membrane damage   (MGI Ref ID J:169951)
  • abnormal skeletal muscle fiber morphology   (MGI Ref ID J:27793)
    • centrally nucleated skeletal muscle fibers   (MGI Ref ID J:27793)
    • increased variability of skeletal muscle fiber size
      • both fast and slow muscle fiber types show increased size variation   (MGI Ref ID J:27793)
    • skeletal muscle fiber degeneration
      • many degenerating and regenerating fibers   (MGI Ref ID J:27793)
      • foci of degeneration are typically large, irregularly shaped and involve 20-50 necrotic fibers   (MGI Ref ID J:27793)
    • skeletal muscle fiber necrosis
      • in addition to foci of 20-50 necrotic fibers, individual or smaller groups of necrotic fibers are also seen   (MGI Ref ID J:27793)
  • calcified muscle
    • dystrophic calcification is seen ion areas of skeletal muscle necrosis   (MGI Ref ID J:27793)
  • dystrophic muscle   (MGI Ref ID J:144746)
  • myositis
    • accompanies skeletal muscle fiber necrosis   (MGI Ref ID J:27793)
  • immune system phenotype
  • myositis
    • accompanies skeletal muscle fiber necrosis   (MGI Ref ID J:27793)
  • hearing/vestibular/ear phenotype
  • abnormal auditory brainstem response waveform shape
    • prolonged I-IV interpeak latencies   (MGI Ref ID J:27793)
    • decreased wave IV amplitude   (MGI Ref ID J:27793)
    • mean wave IV threshold increased   (MGI Ref ID J:27793)
  • sensorineural hearing loss   (MGI Ref ID J:27793)
  • cardiovascular system phenotype
  • abnormal myocardium layer morphology
    • focal interstitial myocardial collagen deposition is seen at 10 months of age, indicating cardiac remodeling that occurs following myocardial damage   (MGI Ref ID J:169951)
    • abnormal myocardial fiber morphology
      • mutants exhibit focal patches of cardiac myocyte membrane damage   (MGI Ref ID J:169951)
  • homeostasis/metabolism phenotype
  • abnormal enzyme/coenzyme activity
    • mice exhibit hypoglycosylation of almost all alpha-dystroglycan compared to in wild-type mice   (MGI Ref ID J:144746)
    • laminin-binding activity of alpha-dystroglycan is less than 5% of normal   (MGI Ref ID J:144746)
  • increased circulating creatine kinase level
    • affected animals have an elevated serum CK range compared to controls   (MGI Ref ID J:27793)
  • behavior/neurological phenotype
  • abnormal gait
    • variable severity at 3 weeks of age; some exhibit gait abnormalities and others could not be identified by this observation   (MGI Ref ID J:27793)
  • limb grasping
    • homozygous mice tightly adduct the hindlimbs and curl toes when suspended by the tail   (MGI Ref ID J:27793)
  • growth/size/body phenotype
  • decreased body size
    • variable severity at 3 weeks of age; some are clearly smaller and others could not be identified by size   (MGI Ref ID J:27793)

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

Largemyd/Largemyd

        MYD/Le-Os +/+ Largemyd/J
  • mortality/aging
  • premature death
    • average life span 17.25 weeks, range 5-39 weeks   (MGI Ref ID J:5670)
  • behavior/neurological phenotype
  • abnormal gait
    • hind limbs held close to the body producing a short, shuffling gait   (MGI Ref ID J:5670)
    • hind limbs never extended and dragged   (MGI Ref ID J:5670)
  • limb grasping
    • involves hind limbs   (MGI Ref ID J:5670)
    • adduction of hind legs, flexion of the knee, ankles and toes   (MGI Ref ID J:5670)
    • severe contraction of hind limbs sometimes by 3-4 months of age   (MGI Ref ID J:5670)
  • muscle phenotype
  • abnormal muscle morphology   (MGI Ref ID J:5670)
    • abnormal skeletal muscle fiber morphology
      • variable fiber size   (MGI Ref ID J:5670)
      • loss of striation   (MGI Ref ID J:5670)
      • central migration of nuclei   (MGI Ref ID J:5670)
      • nuclear "rowing"   (MGI Ref ID J:5670)
    • calcified muscle
      • elevated calcium levels in skeletal muscles, particularly the diaphragm   (MGI Ref ID J:12034)
      • heart not affected   (MGI Ref ID J:12034)
    • dystrophic muscle   (MGI Ref ID J:5670)
    • muscle degeneration   (MGI Ref ID J:5670)
  • abnormal muscle physiology   (MGI Ref ID J:5670)
    • myopathy
      • diffuse and progressive myopathy   (MGI Ref ID J:5670)
      • widely distributed focal lesions in skeletal muscles as early as 16 days of age   (MGI Ref ID J:5670)
    • myositis
      • mononuclear cell infiltration of areas surrounding degenerating fibers   (MGI Ref ID J:5670)
  • nervous system phenotype
  • abnormal myelination
    • areas where nerves are completely deficient in myelin   (MGI Ref ID J:5974)
  • abnormal spinal nerve morphology
    • areas completely deficient in myelin   (MGI Ref ID J:5974)
    • not every root is affected   (MGI Ref ID J:5974)
    • observed in dorsal roots T13 to S1 and Ventral roots L1 to S1 (except L5)   (MGI Ref ID J:5974)
    • L3 and L4 ventral roots most severely affected   (MGI Ref ID J:5974)
  • absent Schwann cells
    • usually unmyelinated nerves lack Schwann cells but sometimes Schwann cells present but lacking myelin   (MGI Ref ID J:5974)
  • growth/size/body phenotype
  • abnormal tongue morphology
    • musculature of tongue not affected until later   (MGI Ref ID J:5670)
    • subepithelial fibrosis in tongues of older mice   (MGI Ref ID J:5670)
  • decreased body weight
    • organ weights reduced comparably with reduced body weigh   (MGI Ref ID J:5670)
  • postnatal growth retardation
    • very severe at weaning   (MGI Ref ID J:5670)
    • growth improved after weaning but mice always small   (MGI Ref ID J:5670)
  • skeleton phenotype
  • abnormal bone structure
    • thinning of all bones examined   (MGI Ref ID J:12034)
  • kyphosis
    • thoracic kyphosis by 6-8 weeks of age   (MGI Ref ID J:5670)
    • becoming progressively worse with age   (MGI Ref ID J:5670)
  • reproductive system phenotype
  • reduced fertility
    • although not sterile, reproduction is very poor   (MGI Ref ID J:5670)
  • immune system phenotype
  • myositis
    • mononuclear cell infiltration of areas surrounding degenerating fibers   (MGI Ref ID J:5670)
  • digestive/alimentary phenotype
  • abnormal tongue morphology
    • musculature of tongue not affected until later   (MGI Ref ID J:5670)
    • subepithelial fibrosis in tongues of older mice   (MGI Ref ID J:5670)
  • craniofacial phenotype
  • abnormal tongue morphology
    • musculature of tongue not affected until later   (MGI Ref ID J:5670)
    • subepithelial fibrosis in tongues of older mice   (MGI Ref ID J:5670)

Largemyd/Largemyd

        B6.Cg-Largemyd/Pjn
  • vision/eye phenotype
  • abnormal eye electrophysiology
    • amplitude of b-wave responses is reduced and delayed at all flash intensities in 2 month old mice   (MGI Ref ID J:100214)
    • larger negative polarity a-wave in response to intermediate flash intensities in 2 month old mice   (MGI Ref ID J:100214)
    • maximum amplitude of a-wave reduced in response to highest flash intensities in 2 month old mice   (MGI Ref ID J:100214)
  • abnormal retinal layer morphology   (MGI Ref ID J:100214)
    • disorganized retinal outer plexiform layer
      • layer is disorganized with a reduction in synaptic complexes   (MGI Ref ID J:100214)
      • mitochondria are swollen with severe disruption of cristae   (MGI Ref ID J:100214)
      • exhibits extracelluelar edema   (MGI Ref ID J:100214)
      • layer is thinner than in control littermates   (MGI Ref ID J:100214)
    • thin retinal outer nuclear layer
      • almost 50% thinner than in controls   (MGI Ref ID J:100214)
  • muscle phenotype
  • abnormal diaphragm morphology
    • exhibits prominent interstial fibrosis with extensive degeneration and regeneration of myofibers at 1.5 months of age   (MGI Ref ID J:100214)
    • by 4 months diaphragm exhibits necrosis and fatty infiltration   (MGI Ref ID J:100214)
  • abnormal soleus morphology
    • occasional signs of fiber-type grouping in 6 month old mice   (MGI Ref ID J:100214)
  • dilated cardiomyopathy
  • cardiovascular system phenotype
  • abnormal myocardium layer morphology
    • myocardium exhibits mild to moderate areas of cardiomyocyte degeneration with mycytolysis, necrosis and interstitial fibrosis in 5 month old mice   (MGI Ref ID J:100214)
    • lesions observed in the left and right atria and ventricles   (MGI Ref ID J:100214)
  • dilated cardiomyopathy
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Neurobiology Research
Muscular Dystrophy
      Dystroglycanopathy

Largemyd related

Neurobiology Research
Muscular Dystrophy
      Dystroglycanopathy

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Largemyd
Allele Name myodystrophy
Allele Type Spontaneous
Common Name(s) Largemyd; fg; froggy; myd;
Strain of OriginSTOCK Edn3
Gene Symbol and Name Large, like-glycosyltransferase
Chromosome 8
Gene Common Name(s) BPFD#36; MDC1D; MDDGA6; MDDGB6; Mbp-1; Mbp1; enervated; enr; fg; froggy; mKIAA0609; myd; myelin basic protein transgene; myodystrophy;
Molecular Note The mutation underlying the myodystrophy phenotype has been determined to be an intragenic deletion in the glycotransferase gene, Large. The deletion of exons 5-7 cause a frameshift and a premature stop codon before the first two catalytic domains. [MGI Ref ID J:69796]
 
Allele Symbol a
Allele Name nonagouti
Allele Type Spontaneous
Strain of Originold mutant of the mouse fancy
Gene Symbol and Name a, nonagouti
Chromosome 2
Gene Common Name(s) AGSW; AGTI; AGTIL; ASP; As; SHEP9; agouti; agouti signal protein; agouti suppressor;
General Note Phenotypic Similarity to Human Syndrome: Metabolic Syndrome in mice homozygous for Apoetm1Unc and heterozygous for Ay and a (J:177084)
Molecular Note Characterization of this allele shows an insertion of DNA comprised of a 5.5kb virus-like element, VL30, into the first intron of the agouti gene. The VL30 element itself contains an additional 5.5 kb sequence, flanked by 526 bp of direct repeats. The host integration site is the same as for at-2Gso and Aw-38J and includes a duplication of four nucleotides of host DNA and a deletion of 2 bp from the end of each repeat. Northern analysis of mRNA from skin of homozygotes shows a smaller agouti message and levels 8 fold lower than found in wild-type. [MGI Ref ID J:16984] [MGI Ref ID J:24934]

Genotyping

Genotyping Information

Genotyping Protocols

Largemyd, Standard PCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Additional References

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Largemyd related

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a related

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Rakyan VK; Chong S; Champ ME; Cuthbert PC; Morgan HD; Luu KV; Whitelaw E. 2003. Transgenerational inheritance of epigenetic states at the murine Axin(Fu) allele occurs after maternal and paternal transmission. Proc Natl Acad Sci U S A 100(5):2538-43. [PubMed: 12601169]  [MGI Ref ID J:82396]

Rice RH; Bradshaw KM; Durbin-Johnson BP; Rocke DM; Eigenheer RA; Phinney BS; Sundberg JP. 2012. Differentiating inbred mouse strains from each other and those with single gene mutations using hair proteomics. PLoS One 7(12):e51956. [PubMed: 23251662]  [MGI Ref ID J:195664]

Rosenfeld CS; Sieli PT; Warzak DA; Ellersieck MR; Pennington KA; Roberts RM. 2013. Maternal exposure to bisphenol A and genistein has minimal effect on A(vy)/a offspring coat color but favors birth of agouti over nonagouti mice. Proc Natl Acad Sci U S A 110(2):537-42. [PubMed: 23267115]  [MGI Ref ID J:193279]

Russell ES. 1948. A Quantitative Histological Study of the Pigment Found in the Coat Color Mutants of the House Mouse. II. Estimates of the Total Volume of Pigment. Genetics 33(3):228-36. [PubMed: 17247280]  [MGI Ref ID J:148462]

Russell ES. 1946. A Quantitative Histological Study of the Pigment Found in the Coat-Color Mutants of the House Mouse. I. Variable Attributes of the Pigment Granules. Genetics 31(3):327-46. [PubMed: 17247200]  [MGI Ref ID J:148463]

Russell ES. 1949. A Quantitative Histological Study of the Pigment Found in the Coat-Color Mutants of the House Mouse. IV. the Nature of the Effects of Genic Substitution in Five Major Allelic Series. Genetics 34(2):146-66. [PubMed: 17247308]  [MGI Ref ID J:12958]

Russell LB. 1964. Genetic and Functional Mosaicism in the Mouse. In: The Role of the Chromosomes in Development. Academic Press, New York.  [MGI Ref ID J:29504]

Russell LB; Cupp McDaniel MN; Woodiel FN,. 1963. Crossing over within the a "locus" of the mouse Genetics 48:907 Abstr.  [MGI Ref ID J:174047]

SILVERS WK. 1958. An experimental approach to action of genes at the agouti locus in the mouse. III. Transplants of newborn Aw-, A-and at-skin to Ay-, Aw-, A-and aa hosts. J Exp Zool 137(1):189-96. [PubMed: 13563791]  [MGI Ref ID J:13013]

Sakurai T; Ochiai H; Takeuchi T. 1975. Ultrastructural change of melanosomes associated with agouti pattern formation in mouse hair. Dev Biol 47(2):466-71. [PubMed: 1204945]  [MGI Ref ID J:5606]

Silvers WK. 1979. The Coat Colors of Mice; A Model for Mammalian Gene Action and Interaction. In: The Coat Colors of Mice. Springer-Verlag, New York.  [MGI Ref ID J:78801]

Soeller WC; Janson J; Hart SE; Parker JC; Carty MD; Stevenson RW; Kreutter DK; Butler PC. 1998. Islet amyloid-associated diabetes in obese A(vy)/a mice expressing human islet amyloid polypeptide. Diabetes 47(5):743-50. [PubMed: 9588445]  [MGI Ref ID J:133694]

Staats J. 1985. Standardized Nomenclature for Inbred Strains of Mice: eighth listing. Cancer Res 45(3):945-77. [PubMed: 3971387]  [MGI Ref ID J:50296]

Suto J. 2008. Coincidence of loci for glucosuria and obesity in type 2 diabetes-prone KK-Ay mice. Med Sci Monit 14(2):CR65-74. [PubMed: 18227763]  [MGI Ref ID J:131439]

Suto J. 2009. Identification of multiple quantitative trait loci affecting the size and shape of the mandible in mice. Mamm Genome 20(1):1-13. [PubMed: 19067046]  [MGI Ref ID J:143893]

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Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $2140.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We willfulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $2782.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We willfulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

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Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.


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The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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phone:207-288-6470

JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


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