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Description
The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.
Strain Information
Type Mutant Stock; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Species laboratory mouse Appearance
black
Related Genotype: a/a Tcirg1oc/+ or a/a +/?Description
Mice homozygous for the osteosclerotic spontaneous mutation (oc) can be recognized at about 10 days by failure of eruption of the incisors, clubbed feet, and circling behavior. Homozygous mutant mice may also have a kinked tail. They grow normally for about the first 10 days of life, then lose weight or at least fail to gain.Development
Tcirg1oc arose in a C57BL/6J stock in 1964. A Tcirg1oc/+ female was crossed to a gl/+ male. This is believed to have been an allele test with grey-lethal. The background of the gl/+ mouse is unknown, but it arrived at The Jackson Laboratory from George Jay in 1954 and may have been crossed to C3H once or twice. Then Tcirg1oc/+ sibling matings were continued until F10 at which time the inbreeding line was dying out. Subsequently, Tcirg1oc/+ or ovarian transplants were then used at each generation to breed to B6C3Fe-a/aF1 hybrids. In 1984 at N20 the stock was put into the Frozen Embryo Repository.
Control Information
| Control | ||
|---|---|---|
| Untyped from the colony | ||
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying a allele
View Strains carrying a (103 strains)
Phenotype
Phenotype Information
Clubfoot, Congenital; CCF - Models with phenotypic similarity to human disease where etiologies are distinct.2 Osteopetrosis, Autosomal Recessive 1; OPTB1 - Models with phenotypic similarity to human disease where etiologies involve orthologs.1
1 Human genes are associated with this disease. Orthologs of those genes appear in the mouse genotype(s). assigned by genotype
Tcirg1oc/Tcirg1oc
B6C3Fe a/a-Tcirg1oc/J
- mortality/aging
- complete postnatal lethality
- mice die by day 20 and lose weight several days before death (MGI Ref ID J:7870)
- skeleton phenotype
- abnormal long bone hypertrophic chondrocyte zone
- the columns of hypertrophic chondrocytes are distorted (MGI Ref ID J:7766)
- increased width of hypertrophic chondrocyte zone (MGI Ref ID J:7766)
- abnormal long bone metaphysis morphology
- unlike in wild-type mice, metaphyseal bones contain large, central vascular channels that abut epiphyseal cartilage (MGI Ref ID J:7870)
- unlike in wild-type mice, cytoplasmic vacuolizations are present next to the trabecular surfaces (MGI Ref ID J:7870)
- unlike in wild-type mice, the calcified cartilage cores of the metaphyseal trabeculae are outlines in darkly staining line and wide expanses of unmineralized bone matrix (MGI Ref ID J:7870)
- the junction between the growth plate and the metaphysis exhibits a paucity of capillary loops invading the lacunae in the hypertrophic zone (MGI Ref ID J:7766)
- the trabeculae is disorganized and thickened (MGI Ref ID J:7766)
- unmineralized or underminiralized areas are observed unlike in wild-type mice (MGI Ref ID J:7766)
- abnormal osteoclast morphology
- osteoclasts are smaller than in wild-type mice (MGI Ref ID J:7870)
- failure of secondary bone resorption (MGI Ref ID J:7766)
- increased long bone epiphyseal plate size
- osteopetrosis
- hematopoietic system phenotype
- abnormal osteoclast morphology
- osteoclasts are smaller than in wild-type mice (MGI Ref ID J:7870)
- extramedullary hematopoiesis
- extramedullary hematopoiesis continues after birth in the spleen and liver unlike in wild-type mice (MGI Ref ID J:7870)
- increased megakaryocyte cell number
- prominent megakaryocytosis is present in the liver (MGI Ref ID J:7870)
- growth/size phenotype
- decreased body size (MGI Ref ID J:61295)
- endocrine/exocrine gland phenotype
- abnormal thyroid gland morphology
- thyroid tissues are more prominent than in wild-type mice (MGI Ref ID J:7870)
- decreased insulin secretion (MGI Ref ID J:116082)
- behavior/neurological phenotype
- circling (MGI Ref ID J:61295)
- circling is observed two weeks after birth (MGI Ref ID J:7870)
- homeostasis/metabolism phenotype
- decreased circulating insulin level
- mice fail to exhibit an increase in insulin levels following administration of glucose (MGI Ref ID J:116082)
- decreased insulin secretion (MGI Ref ID J:116082)
- limbs/digits/tail phenotype
- abnormal long bone hypertrophic chondrocyte zone
- the columns of hypertrophic chondrocytes are distorted (MGI Ref ID J:7766)
- increased width of hypertrophic chondrocyte zone (MGI Ref ID J:7766)
- abnormal long bone metaphysis morphology
- unlike in wild-type mice, metaphyseal bones contain large, central vascular channels that abut epiphyseal cartilage (MGI Ref ID J:7870)
- unlike in wild-type mice, cytoplasmic vacuolizations are present next to the trabecular surfaces (MGI Ref ID J:7870)
- unlike in wild-type mice, the calcified cartilage cores of the metaphyseal trabeculae are outlines in darkly staining line and wide expanses of unmineralized bone matrix (MGI Ref ID J:7870)
- the junction between the growth plate and the metaphysis exhibits a paucity of capillary loops invading the lacunae in the hypertrophic zone (MGI Ref ID J:7766)
- the trabeculae is disorganized and thickened (MGI Ref ID J:7766)
- unmineralized or underminiralized areas are observed unlike in wild-type mice (MGI Ref ID J:7766)
- increased long bone epiphyseal plate size
- craniofacial phenotype
- abnormal dentin morphology
- the predentin layer in the molars and incisors are 2- to 3-fold thicker than in wild-type mice (MGI Ref ID J:7870)
- abnormal incisor morphology
- delayed tooth eruption
- tooth eruption is absent or delayed with only one of 23 mice exhibiting a partially erupted incisor at day 10 to 20 and no molars erupt in any of the mice compared to wild-type mice whose incisors erupt at day 10 and whose first molars erupt at day 16 (MGI Ref ID J:7870)
- tooth eruption is absent or delayed (MGI Ref ID J:61295)
- immune system phenotype
- abnormal osteoclast morphology
- osteoclasts are smaller than in wild-type mice (MGI Ref ID J:7870)
The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.
Tcirg1oc/Tcirg1oc
C57BL/6J-Vps33abf
- mortality/aging
- premature death
- mice die between 30 and 40 days of age although one mouse survived longer (MGI Ref ID J:28464)
- skeleton phenotype
- abnormal bone ossification
- extra bone deposits are present on the chondrocostal junction and in the hindlimb (MGI Ref ID J:28464)
- failure of secondary bone resorption (MGI Ref ID J:28464)
- behavior/neurological phenotype
- circling
- circling behavior is apparent at day 10 to 12 and worsens with age (MGI Ref ID J:28464)
- limbs/digits/tail phenotype
- clubfoot (MGI Ref ID J:28464)
- craniofacial phenotype
- absent teeth (MGI Ref ID J:28464)
This mouse can be used to support research in many areas including:
Tcirg1oc relatedInternal/Organ Research
Skeleton
Bone
Developmental Biology Research
Skeletal Defects
Endocrine Deficiency Research
Bone/Bone Marrow Defects
Neurobiology Research
Hearing Defects
Sensorineural Research
Hearing Defects
Genes & Alleles
Gene & Allele Information provided by MGI
| Allele Symbol | Tcirg1oc | ||
|---|---|---|---|
| Allele Name | osteosclerotic | ||
| Allele Type | Spontaneous | ||
| Common Name(s) | Atp6i-; oc; | ||
| Strain of Origin | C57BL/6J-Vps33a | ||
| Gene Symbol and Name | Tcirg1, T cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A3 | ||
| Chromosome | 19 | ||
| Gene Common Name(s) | ATP6N1C; ATP6V0A3; ATP6a3; ATPase, H+ transporting, lysosomal I; Atp6i; OC-116; OC-116kDa; OC116; OPTB1; Stv1; TIRC7; V-ATPase a3; Vph1; a3; oc; osteosclerotic; | ||
| Molecular Note | This mutation was defined as a 1579 bp deletion starting in the middle of intron 1 and extending 62 bp into exon 3. [MGI Ref ID J:61295] | ||
| Allele Symbol | a | ||
| Allele Name | nonagouti | ||
| Allele Type | Spontaneous | ||
| Strain of Origin | old mutant of the mouse fancy | ||
| Gene Symbol and Name | a, nonagouti | ||
| Chromosome | 2 | ||
| Gene Common Name(s) | AGSW; AGTI; AGTIL; ASP; As; SHEP9; agouti; agouti signal protein; agouti suppressor; | ||
| Molecular Note | Characterization of this allele shows an insertion of DNA comprised of a 5.5kb virus-like element, VL30, into the first intron of the agouti gene. The VL30 element itself contains an additional 5.5 kb sequence, flanked by 526 bp of direct repeats. The host integration site is the same as for at-2Gso and Aw-38J and includes a duplication of four nucleotides of host DNA and a deletion of 2 bp from the end of each repeat. Northern analysis of mRNA from skin of homozygotes shows a smaller agouti message and levels 8 fold lower than found in wild-type. [MGI Ref ID J:16984] [MGI Ref ID J:24934] | ||
Genotyping
Genotyping Information
Genotyping Protocols
Tcirg1oc, Standard PCR
Helpful Links
Genotyping resources and troubleshooting
References
References provided by MGI
Additional References
Marks SC Jr; Seifert MF; Lane PW. 1985. Osteosclerosis, a recessive skeletal mutation on chromosome 19 in the mouse. J Hered 76(3):171-6. [PubMed: 3998439] [MGI Ref ID J:7870]
Scimeca JC; Franchi A; Trojani C; Parrinello H; Grosgeorge J; Robert C; Jaillon O; Poirier C; Gaudray P; Carle GF. 2000. The gene encoding the mouse homologue of the human osteoclast-specific 116-kDa V-ATPase subunit bears a deletion in osteosclerotic (oc/oc) mutants. Bone 26(3):207-13. [PubMed: 10709991] [MGI Ref ID J:61295]
Udagawa N; Sasaki T; Akatsu T; Takahashi N; Tanaka S; Tamura T; Tanaka H; Suda T. 1992. Lack of bone resorption in osteosclerotic (oc/oc) mice is due to a defect in osteoclast progenitors rather than the local microenvironment provided by osteoblastic cells. Biochem Biophys Res Commun 184(1):67-72. [PubMed: 1567458] [MGI Ref ID J:525]
Tcirg1oc relateda relatedAskmyr M; Holmberg J; Flores C; Ehinger M; Hjalt T; Richter J. 2009. Low-dose busulphan conditioning and neonatal stem cell transplantation preserves vision and restores hematopoiesis in severe murine osteopetrosis. Exp Hematol 37(2):302-8. [PubMed: 19100677] [MGI Ref ID J:146562]
Blin-Wakkach C; Breuil V; Quincey D; Bagnis C; Carle GF. 2006. Establishment and characterization of new osteoclast progenitor cell lines derived from osteopetrotic and wild type mice. Bone 39(1):53-60. [PubMed: 16503212] [MGI Ref ID J:111156]
Blin-Wakkach C; Wakkach A; Quincey D; Carle GF. 2006. Interleukin-7 partially rescues B-lymphopoiesis in osteopetrotic oc/oc mice through the engagement of B220+ CD11b+ progenitors. Exp Hematol 34(7):851-9. [PubMed: 16797412] [MGI Ref ID J:111910]
Blin-Wakkach C; Wakkach A; Sexton PM; Rochet N; Carle GF. 2004. Hematological defects in the oc/oc mouse, a model of infantile malignant osteopetrosis. Leukemia 18(9):1505-11. [PubMed: 15284856] [MGI Ref ID J:93047]
Brady KP; Dushkin H; Fornzler D; Koike T; Magner F; Her H; Gullans S ; Segre GV ; Green RM ; Beier DR. 1999. A novel putative transporter maps to the osteosclerosis (oc) mutation and is not expressed in the oc mutant mouse. Genomics 56(3):254-61. [PubMed: 10087192] [MGI Ref ID J:54028]
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Ferron M; Wei J; Yoshizawa T; Del Fattore A; DePinho RA; Teti A; Ducy P; Karsenty G. 2010. Insulin signaling in osteoblasts integrates bone remodeling and energy metabolism. Cell 142(2):296-308. [PubMed: 20655470] [MGI Ref ID J:164596]
Johansson M; Jansson L; Ehinger M; Fasth A; Karlsson S; Richter J. 2006. Neonatal hematopoietic stem cell transplantation cures oc/oc mice from osteopetrosis. Exp Hematol 34(2):242-9. [PubMed: 16459192] [MGI Ref ID J:106436]
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Scimeca JC; Franchi A; Trojani C; Parrinello H; Grosgeorge J; Robert C; Jaillon O; Poirier C; Gaudray P; Carle GF. 2000. The gene encoding the mouse homologue of the human osteoclast-specific 116-kDa V-ATPase subunit bears a deletion in osteosclerotic (oc/oc) mutants. Bone 26(3):207-13. [PubMed: 10709991] [MGI Ref ID J:61295]
Seifert MF; Marks SC Jr. 1985. Morphological evidence of reduced bone resorption in the osteosclerotic (oc) mouse. Am J Anat 172(2):141-53. [PubMed: 3976544] [MGI Ref ID J:7766]
Sun-Wada GH; Toyomura T; Murata Y; Yamamoto A; Futai M; Wada Y. 2006. The a3 isoform of V-ATPase regulates insulin secretion from pancreatic beta-cells. J Cell Sci 119(Pt 21):4531-40. [PubMed: 17046993] [MGI Ref ID J:116082]
Udagawa N; Sasaki T; Akatsu T; Takahashi N; Tanaka S; Tamura T; Tanaka H; Suda T. 1992. Lack of bone resorption in osteosclerotic (oc/oc) mice is due to a defect in osteoclast progenitors rather than the local microenvironment provided by osteoblastic cells. Biochem Biophys Res Commun 184(1):67-72. [PubMed: 1567458] [MGI Ref ID J:525]
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Quevedo WC Jr; Holstein TJ. 1992. The shift from physiological genetics to molecular genetics in the study of mouse tyrosinase. Pigment Cell Res Suppl 2:57-60. [PubMed: 1409439] [MGI Ref ID J:3852]
RUSSELL ES. 1949. A quantitative histological study of the pigment found in the coat-color mutants of the house mouse; interdependence among the variable granule attributes. Genetics 34(2):133-45. [PubMed: 18117146] [MGI Ref ID J:148461]
Rakyan VK; Chong S; Champ ME; Cuthbert PC; Morgan HD; Luu KV; Whitelaw E. 2003. Transgenerational inheritance of epigenetic states at the murine Axin(Fu) allele occurs after maternal and paternal transmission. Proc Natl Acad Sci U S A 100(5):2538-43. [PubMed: 12601169] [MGI Ref ID J:82396]
Russell ES. 1948. A Quantitative Histological Study of the Pigment Found in the Coat Color Mutants of the House Mouse. II. Estimates of the Total Volume of Pigment. Genetics 33(3):228-36. [PubMed: 17247280] [MGI Ref ID J:148462]
Russell ES. 1946. A Quantitative Histological Study of the Pigment Found in the Coat-Color Mutants of the House Mouse. I. Variable Attributes of the Pigment Granules. Genetics 31(3):327-46. [PubMed: 17247200] [MGI Ref ID J:148463]
Russell ES. 1949. A Quantitative Histological Study of the Pigment Found in the Coat-Color Mutants of the House Mouse. IV. the Nature of the Effects of Genic Substitution in Five Major Allelic Series. Genetics 34(2):146-66. [PubMed: 17247308] [MGI Ref ID J:12958]
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SILVERS WK. 1958. An experimental approach to action of genes at the agouti locus in the mouse. III. Transplants of newborn Aw-, A-and at-skin to Ay-, Aw-, A-and aa hosts. J Exp Zool 137(1):189-96. [PubMed: 13563791] [MGI Ref ID J:13013]
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Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, RG10/RG30.
Purchasing information
Pricing, Supply Level & Notes, Controls
| Pricing for USA, Canada and Mexico shipping destinations |
|
 |
Cryopreserved
Cryopreserved Mice - Ready for Recovery
Animals Provided
Price (US dollars $) Cryorecovery* $1980.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Embryos
Price (US dollars $) Frozen Embryo $1600.00 Standard Supply
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information.
Supply Notes
- Cryopreserved Embryos
Available to most shipping destinations1
This strain is also available as cryopreserved embryos2. Orders for cryopreserved embryos may be placed with our Customer Service Department. Experienced technicians at The Jackson Laboratory have recovered frozen embryos of this strain successfully. We will provide you enough embryos to perform two embryo transfers. The Jackson Laboratory does not guarantee successful recovery at your facility. For complete information on purchasing embryos, please visit our Cryopreserved Embryos web page.
1 Shipments cannot be made to Australia due to Australian government import restrictions.
2 Embryos for most strains are cryopreserved at the two cell stage while some strains are cryopreserved at the eight cell stage. If this information is important to you, please contact Customer Service.- Cryorecovery - Standard.
We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. The total number of animals provided, their gender and genotype will vary. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 13 and 16 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).
| Pricing for International shipping destinations |
|
|
Cryopreserved
Cryopreserved Mice - Ready for Recovery
Animals Provided
Price (US dollars $) Cryorecovery* $2574.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Embryos
Price (US dollars $) Frozen Embryo $2080.00 Standard Supply
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information.
Supply Notes
- Cryopreserved Embryos
Available to most shipping destinations1
This strain is also available as cryopreserved embryos2. Orders for cryopreserved embryos may be placed with our Customer Service Department. Experienced technicians at The Jackson Laboratory have recovered frozen embryos of this strain successfully. We will provide you enough embryos to perform two embryo transfers. The Jackson Laboratory does not guarantee successful recovery at your facility. For complete information on purchasing embryos, please visit our Cryopreserved Embryos web page.
1 Shipments cannot be made to Australia due to Australian government import restrictions.
2 Embryos for most strains are cryopreserved at the two cell stage while some strains are cryopreserved at the eight cell stage. If this information is important to you, please contact Customer Service.- Cryorecovery - Standard.
We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. The total number of animals provided, their gender and genotype will vary. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 13 and 16 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).
|
|
|
Standard Supply
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information.
General Supply Notes
- Genomic DNA is available for this strain from the Mouse DNA Resource.
Control Information
| Control | ||
|---|---|---|
| Untyped from the colony | ||
| Considerations for Choosing Controls | ||
| Control Pricing Information for Genetically Engineered Mutant Strains. | ||
Payment Terms and Conditions
Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.
See Terms of Use tab for General Terms and Conditions
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering Information
JAX® Mice
Surgical and Preconditioning Services
JAX® Services
Customer Services and Support
Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
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Terms of Use
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Contact information
General inquiriesContracts Administration
| phone: | 207-288-6470 |
| fax: | 207-288-6655 |
JAX® Mice, Products & Services Conditions of Use
"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.No Warranty
MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.
In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.
No Liability
In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.
MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.
The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.
Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.