| |||||||||||
- Description
- Phenotype
- Genes & alleles
- Genotyping
- Health & husbandry
- References
- Purchasing information
- Terms of Use
Description
Strain Information
Former Names B6C3Fe-a/a-Csf1op (Changed: 15-JUL-09 ) B6C3Fe a/a-Csf1op/J (Changed: 15-JUL-09 ) B6C3Fe-a/a-Csf1op (Changed: 15-DEC-04 ) Type Mutant Stock; Spontaneous Mutation; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Mating System Heterozygote x Heterozygote (Female x Male) 20-JUL-09 Species laboratory mouse Generation N58F6 (19-NOV-09) Appearance
black, osteopetrosis
Related Genotype: a/a Csf1op/Csf1op
black, unaffected
Related Genotype: a/a Csf1op/+ or a/a ?/+Description
Mice homozygous for the osteopetrosis spontaneous mutation (Csf1op) are viable and exhibit osteopetrosis. The osteoclasts are the primary cell type affected in homozygous mutant mice. This results in a generalized macrophage deficiency, monocytopenia, and defective bone remodeling. Homozygous mutant mice also have abnormal calcium regulation, impaired dental growth and female mice fail to lactate. Total leukocyte counts are reduced and marrow cells are decreased to one-tenth of normal control mice. Homozygous mutant mice have a deficient microglia and macrophage response, and therefore may be useful tools to study the role of glia in neurological disease if mated to transgenic models of neurodegenerative disease.Development
The osteopetrotic mutation arose spontaneously in 1970 at The Jackson Laboratory in the beginning congenic stock that became B6.DW-Pou1f1dw/J, which was then at generation N3. Osteopetrotic heterozygotes were backcrossed to C57BL/6J for 7 generations. The line was then bred once to C3FeLe.B6-a/a/J and the strain was subsequently maintained via homozygous ovarian transplant host bred to (C57BL/6J x C3FeLe.B6-a/a/J)F1 then intercross of the obligate heterozygous offspring.
Control Information
| Control | ||
|---|---|---|
| Untyped from the colony | ||
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying a allele
View Strains carrying a (104 strains)
Additional Web Information
Genetic Quality Control Annual Report
Visit the Parkinson's Disease Resource site for helpful information on Parkinson's and research resources.
Phenotype
Phenotype Information
Osteopetrosis, Autosomal Recessive 1; OPTB1 - Models with phenotypic similarity to human disease where etiologies are distinct.2
2 Human genes are associated with this disease. Orthologs of those genes do not appear in the mouse genotype(s).
assigned by genotype
Csf1op/Csf1op
B6C3Fe a/a-Csf1op/J
- lethality-postnatal
- postnatal lethality (MGI Ref ID J:73663)
- reduced numbers of homozygotes survive to weaning
- growth/size phenotype
- decreased body weight (MGI Ref ID J:104139)
- low body weight
- postnatal growth retardation (MGI Ref ID J:73663)
- slower growth rate
- immune system phenotype
- abnormal Kupffer cell morphology (MGI Ref ID J:26978)
- 30% fewer Kupffer cells than normal littermates
- irregular distribution of Kupffer cells in liver lobules
- Kupffer cells possess phagocytized blood cells, poorly developed organelles and microvilli projections
- abnormal Langerhans cell morphology (MGI Ref ID J:112594)
- bone chimera experiments suggest hematopoietic precursors to Langerhans cells have reduced capability to differentiate into Langerhan cells when skin is inflammed
- absent Langerhans cell (MGI Ref ID J:112594)
- absence of Langerhans cells in newborns but numbers recover in adults
- abnormal Langerhans cell physiology (MGI Ref ID J:112594)
- Langerhan cell numbers are slow to recover after UV irradiation
- two weeks after UV irradiation, numbers are 25% compared to unirradiated mutant mice while at the same timepoint irradiated wild-type LC numbers are close to 100% of control
- abnormal microglial cell morphology (MGI Ref ID J:49613)
- reduced numbers of microglial cells in frontal cortex, parietal cortex and corpus callosum
- microglial cells in frontal cortex have smaller cell bodies and shorter cytoplasmic processes
- abnormal osteoclast morphology (MGI Ref ID J:26978)
- reduced size and number of multinuclear osteoclasts
- abnormal osteoclast differentiation (MGI Ref ID J:4732)
- daily injection of exogenous M-CSF recruits functional osteoclasts
- minimally a single injection of 5 micrograms rhM-CSF is needed for transient recruitment of osteoclasts
- abnormal perivascular macrophage morphology (MGI Ref ID J:49613)
- reduced numbers of perivascular macrophages (as identified by F4/80 staining) are found in parietal cortex
- abnormal spleen red pulp morphology (MGI Ref ID J:26978)
- extensive extramedullary hematopoiesis
- abnormal splenic cell ratio (MGI Ref ID J:104139)
- increased concentration of CFU-S cells, however , size and differentiation pattern of spleen colonies is normal
- spleen mostly composed of fibroblastoid cells
- reduced number of macrophages
- abnormal thymus medulla morphology (MGI Ref ID J:26978)
- atrophic with numerous macrophages
- decreased leukocyte cell number (MGI Ref ID J:104139)
- decreased macrophage cell number (MGI Ref ID J:26978)
- decreased numbers of macrophages in liver, spleen, bone marrow, kidney, subcutaneous tissue, uterus and ovary
- macrophages exhibit intracytoplasmic organelles in splenic, thymic and bone marrow
- macrophage organelles and microvillous projections are poorly developed
- decreased numbers in spleen and marrow
- decreased monocyte cell number (MGI Ref ID J:104139)
- almost complete absence of monocytes in peripheral blood
- decreased thymus cortex area (MGI Ref ID J:26978)
- consists mostly of thymic epithelial cells
- skeleton phenotype
- abnormal bone marrow cavity morphology (MGI Ref ID J:26978)
- reduced numbers of hematopoietic cells
- excessive amount of bone trabeculae
- abnormal bone marrow morphology (MGI Ref ID J:73663)
- femoral bone marrow cellularity is reduced early but recovers to control levels by 8 months of age
- abnormal cancellous bone morphology (MGI Ref ID J:73663)
- higher levels of trabecular bone
- abnormal femur morphology (MGI Ref ID J:18356)
- distal end is wide, diaphysis does not have a well defined cortex
- abnormal long bone hypertrophic chondrocyte zone (MGI Ref ID J:26978)
- abnormal osteoclast morphology (MGI Ref ID J:26978)
- reduced size and number of multinuclear osteoclasts
- abnormal osteoclast differentiation (MGI Ref ID J:4732)
- daily injection of exogenous M-CSF recruits functional osteoclasts
- minimally a single injection of 5 micrograms rhM-CSF is needed for transient recruitment of osteoclasts
- abnormal parietal bone morphology (MGI Ref ID J:18356)
- parietal bone grows only through the trabecular bone formation with no subperiosteal bone lamellae forming as in normal mice
- abnormal tibia morphology (MGI Ref ID J:26978)
- proximal end is wide, diaphysis does not have a well defined cortex
- domed skull (MGI Ref ID J:18356)
- flat bone grows without resorption while keeping the normal primary curvature resulting in a more globular skull
- reproductive system phenotype
- abnormal lactation (MGI Ref ID J:20519)
- only 10% of females can lactate, however, lactation in this subset is inefficient
- abnormal mammary gland development (MGI Ref ID J:20519)
- postpartum females exhibit incompletely differentiated mammary gland tissue with a nonsecretory phenotype
- alveolar cells are cuboidal, contain large lipid vesicles and the lumen is small or unformed
- abnormal branching of the mammary ductal tree (MGI Ref ID J:20519)
- ductal structures are poorly developed with incomplete arborization
- abnormal mammary gland growth during pregnancy (MGI Ref ID J:20519)
- lobulo-alveolar development is premature and occupies 56% of mammary gland by day 18 of pregnancy
- abnormal uterus development (MGI Ref ID J:26978)
- poor development of glandular epithelia
- endometrium hypoplasia (MGI Ref ID J:26978)
- endometrium is hypoplastic
- increased testis weight (MGI Ref ID J:34371)
- as a percentage of body weight, testicular tissue is increased over controls
- myometrium hypoplasia (MGI Ref ID J:26978)
- myometrium is hypoplastic
- necrospermia (MGI Ref ID J:34371)
- percentage of dead sperm is two times higher than controls
- oligozoospermia (MGI Ref ID J:34371)
- epididymal sperm count 60% lower than control
- reduced male fertility (MGI Ref ID J:34371)
- males take 5 times longer to mate than controls
- males mate on the first night, but not on subsequent nights in timed mating experiments
- nervous system phenotype
- abnormal microglial cell morphology (MGI Ref ID J:49613)
- reduced numbers of microglial cells in frontal cortex, parietal cortex and corpus callosum
- microglial cells in frontal cortex have smaller cell bodies and shorter cytoplasmic processes
- abnormal summary potential (MGI Ref ID J:19549)
- total intracortical transmembrane current significantly reduced as measured by intracortical VEP
- altered neural firing as demonstrated by multiple unit activity (MUA) measurement
- amyloid beta deposits (MGI Ref ID J:87261)
- 100 to 200 fibrillar plaques observed in cerebral cortex
- 20 to 60 plaques observed in amygdala and hypothalamus
- small number of plaques observed in hippocampus
- decreased pyramidal neuron number (MGI Ref ID J:87261)
- hippocampal neuron loss in CA1 and CA3 regions
- hematopoietic system phenotype
- abnormal Kupffer cell morphology (MGI Ref ID J:26978)
- 30% fewer Kupffer cells than normal littermates
- irregular distribution of Kupffer cells in liver lobules
- Kupffer cells possess phagocytized blood cells, poorly developed organelles and microvilli projections
- abnormal Langerhans cell morphology (MGI Ref ID J:112594)
- bone chimera experiments suggest hematopoietic precursors to Langerhans cells have reduced capability to differentiate into Langerhan cells when skin is inflammed
- absent Langerhans cell (MGI Ref ID J:112594)
- absence of Langerhans cells in newborns but numbers recover in adults
- abnormal microglial cell morphology (MGI Ref ID J:49613)
- reduced numbers of microglial cells in frontal cortex, parietal cortex and corpus callosum
- microglial cells in frontal cortex have smaller cell bodies and shorter cytoplasmic processes
- abnormal osteoclast morphology (MGI Ref ID J:26978)
- reduced size and number of multinuclear osteoclasts
- abnormal osteoclast differentiation (MGI Ref ID J:4732)
- daily injection of exogenous M-CSF recruits functional osteoclasts
- minimally a single injection of 5 micrograms rhM-CSF is needed for transient recruitment of osteoclasts
- abnormal perivascular macrophage morphology (MGI Ref ID J:49613)
- reduced numbers of perivascular macrophages (as identified by F4/80 staining) are found in parietal cortex
- abnormal spleen red pulp morphology (MGI Ref ID J:26978)
- extensive extramedullary hematopoiesis
- abnormal splenic cell ratio (MGI Ref ID J:104139)
- increased concentration of CFU-S cells, however , size and differentiation pattern of spleen colonies is normal
- spleen mostly composed of fibroblastoid cells
- reduced number of macrophages
- abnormal thymus medulla morphology (MGI Ref ID J:26978)
- atrophic with numerous macrophages
- decreased bone marrow cell number (MGI Ref ID J:104139)
- number of cells 10 fold less than controls
- marrow mostly composed of fibroblastoid cells
- reduced numbers of CFU-S cells
- decreased leukocyte cell number (MGI Ref ID J:104139)
- decreased macrophage cell number (MGI Ref ID J:26978)
- decreased numbers of macrophages in liver, spleen, bone marrow, kidney, subcutaneous tissue, uterus and ovary
- macrophages exhibit intracytoplasmic organelles in splenic, thymic and bone marrow
- macrophage organelles and microvillous projections are poorly developed
- decreased numbers in spleen and marrow
- decreased monocyte cell number (MGI Ref ID J:104139)
- almost complete absence of monocytes in peripheral blood
- decreased thymus cortex area (MGI Ref ID J:26978)
- consists mostly of thymic epithelial cells
- extramedullary hematopoiesis (MGI Ref ID J:26978)
- observed in splenic red pulp
- liver/biliary system phenotype
- abnormal Kupffer cell morphology (MGI Ref ID J:26978)
- 30% fewer Kupffer cells than normal littermates
- irregular distribution of Kupffer cells in liver lobules
- Kupffer cells possess phagocytized blood cells, poorly developed organelles and microvilli projections
- limbs/digits/tail phenotype
- abnormal femur morphology (MGI Ref ID J:18356)
- distal end is wide, diaphysis does not have a well defined cortex
- abnormal long bone hypertrophic chondrocyte zone (MGI Ref ID J:26978)
- abnormal tibia morphology (MGI Ref ID J:26978)
- proximal end is wide, diaphysis does not have a well defined cortex
- endocrine/exocrine gland phenotype
- abnormal lactation (MGI Ref ID J:20519)
- only 10% of females can lactate, however, lactation in this subset is inefficient
- abnormal mammary gland development (MGI Ref ID J:20519)
- postpartum females exhibit incompletely differentiated mammary gland tissue with a nonsecretory phenotype
- alveolar cells are cuboidal, contain large lipid vesicles and the lumen is small or unformed
- abnormal branching of the mammary ductal tree (MGI Ref ID J:20519)
- ductal structures are poorly developed with incomplete arborization
- abnormal mammary gland growth during pregnancy (MGI Ref ID J:20519)
- lobulo-alveolar development is premature and occupies 56% of mammary gland by day 18 of pregnancy
- increased testis weight (MGI Ref ID J:34371)
- as a percentage of body weight, testicular tissue is increased over controls
- homeostasis/metabolism phenotype
- decreased circulating testosterone level (MGI Ref ID J:34371)
- hearing/vestibular/ear phenotype
- abnormal vestibular system physiology (MGI Ref ID J:19549)
- poorly formed or absent response to surface visual evoked potential (VEP)
- decreased brainstem auditory evoked potential (MGI Ref ID J:19549)
- delayed and diminished response to brainstem auditory evoked potential (BAEP)
- other phenotype
- amyloid beta deposits (MGI Ref ID J:87261)
- 100 to 200 fibrillar plaques observed in cerebral cortex
- 20 to 60 plaques observed in amygdala and hypothalamus
- small number of plaques observed in hippocampus
- cardiovascular system phenotype
- abnormal perivascular macrophage morphology (MGI Ref ID J:49613)
- reduced numbers of perivascular macrophages (as identified by F4/80 staining) are found in parietal cortex
- craniofacial phenotype
- abnormal parietal bone morphology (MGI Ref ID J:18356)
- parietal bone grows only through the trabecular bone formation with no subperiosteal bone lamellae forming as in normal mice
- domed skull (MGI Ref ID J:18356)
- flat bone grows without resorption while keeping the normal primary curvature resulting in a more globular skull
- muscle phenotype
- abnormal masseter muscle morphology (MGI Ref ID J:20589)
- severely atrophied white and intermediate muscle fibers are observed in the superficial region of the masseter muscle
- the progression and extent of atrophy differed among regions of the muscle
- the decrease in diameter of muscle fibers was larger than found in mice fed a granulated diet
- the decrease in sensory input due to underdevelopment of periodontal ligaments in the absence of teeth likely results in atrophy of the masseter muscle
Csf1op/Csf1op
involves: C3HeB/FeJ * C57BL/6J
- homeostasis/metabolism phenotype
- abnormal circulating calcium level (MGI Ref ID J:5634)
- unable to raise serum calcium concentration in response to parathyroid extract (PTE)
- hypophosphatemia (MGI Ref ID J:5634)
- phosphate serum levels are low but calcium levels are normal
- behavior/neurological phenotype
- abnormal eating behavior (MGI Ref ID J:40136)
- pups drink less of the mother's milk possibly due to being unable to compete with normal littermates
- cardiovascular system phenotype
- decreased susceptibility to atherosclerosis (MGI Ref ID J:40136)
- mice on a high fat diet for 15 weeks develop smaller atherosclerosis lesions than do the C57BL/6J controls
- lesions are also less frequent and when present, less advanced with no lesions containing fibrous caps observed
- growth/size phenotype
- decreased body weight (MGI Ref ID J:40136)
- mice have decreased body weight until weaning when they will normalize their weight if fed a liquid diet
- hematopoietic system phenotype
- abnormal osteoclast cell number (MGI Ref ID J:33189)
- decreased osteoclast cell number (MGI Ref ID J:33189)
- at birth the osteoclast population appears normal but quickly decreases to negligible numbers by the time the mouse is 3-4 days of age
- immune system phenotype
- abnormal osteoclast cell number (MGI Ref ID J:33189)
- decreased osteoclast cell number (MGI Ref ID J:33189)
- at birth the osteoclast population appears normal but quickly decreases to negligible numbers by the time the mouse is 3-4 days of age
- skeleton phenotype
- abnormal bone marrow cavity morphology (MGI Ref ID J:5634)
- the excessive accumulations of bone lack marrow cavities
- abnormal bone remodeling (MGI Ref ID J:5634)
- compared with normal littermates, bone matrix formation is significantly elevated before 40 days of age and significantly reduced between 81 days and 10 months of age
- although bone remodeling is reduced, overall decline in rate of bone formation removes excess bone resulting in nearly normal bone
- abnormal osteoclast cell number (MGI Ref ID J:33189)
- decreased osteoclast cell number (MGI Ref ID J:33189)
- at birth the osteoclast population appears normal but quickly decreases to negligible numbers by the time the mouse is 3-4 days of age
- domed skull (MGI Ref ID J:5634)
- mutants are recognized at 10 days of age by a characteristic domed head
- craniofacial phenotype
- absent teeth (MGI Ref ID J:5634)
- noticeably absent at 10 days of age
- at weaning mice need to be provided with soft food in order to thrive
- domed skull (MGI Ref ID J:5634)
- mutants are recognized at 10 days of age by a characteristic domed head
- endocrine/exocrine gland phenotype
- abnormal thyroid parafollicular C-cells (MGI Ref ID J:5634)
- this cell population is increased in this mutation
The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.
Csf1op/Csf1op
C57BL/6J-Csf1op
- skeleton phenotype
- abnormal osteoblast physiology (MGI Ref ID J:5634)
- increased bone matrix formation to postnatal day 40
- decreased bone matrix formation after day 81
- abnormal skeleton morphology (MGI Ref ID J:110981)
- overall skeleton is smaller than in wild-type
- abnormal bone structure (MGI Ref ID J:5634)
- large lipoid masses in vascular and extravascular areas of bone
- abnormal bone marrow cavity morphology (MGI Ref ID J:5634)
- delayed development of bone marrow cavity
- abnormally high numbers of megakaryocytes
- abnormal cancellous bone morphology (MGI Ref ID J:5634)
- long bones filled with primary spongiosa
- abnormal osteoclast morphology (MGI Ref ID J:5634)
- osteoclasts small and few in number
- abnormal distribution of acid phosphatase activity
- decreased osteoclast cell number (MGI Ref ID J:5634)
- osteopetrosis (MGI Ref ID J:5634)
- osteoporosis (MGI Ref ID J:110981)
- mice exhibit osteoporosis
- domed skull (MGI Ref ID J:5634)
- observed by 10 days
- immune system phenotype
- abnormal osteoclast morphology (MGI Ref ID J:5634)
- osteoclasts small and few in number
- abnormal distribution of acid phosphatase activity
- decreased osteoclast cell number (MGI Ref ID J:5634)
- abnormal spleen red pulp morphology (MGI Ref ID J:5634)
- sinusoids less developed
- decreased macrophage cell number (MGI Ref ID J:110981)
- cells expressing F4/80+ (a marker for macrophages) are almost entirely absent
- decreased osteoclast cell number (MGI Ref ID J:5634)
- hematopoietic system phenotype
- abnormal osteoclast morphology (MGI Ref ID J:5634)
- osteoclasts small and few in number
- abnormal distribution of acid phosphatase activity
- decreased osteoclast cell number (MGI Ref ID J:5634)
- abnormal spleen red pulp morphology (MGI Ref ID J:5634)
- sinusoids less developed
- decreased macrophage cell number (MGI Ref ID J:110981)
- cells expressing F4/80+ (a marker for macrophages) are almost entirely absent
- decreased osteoclast cell number (MGI Ref ID J:5634)
- reproductive system phenotype
- reduced fertility (MGI Ref ID J:5634)
- craniofacial phenotype
- abnormal snout morphology (MGI Ref ID J:110981)
- snouts are rounded
- absent incisors (MGI Ref ID J:5634)
- absence of incisors is observed by 10 days
- absent teeth (MGI Ref ID J:110981)
- homozygous mice are toothless
- domed skull (MGI Ref ID J:5634)
- observed by 10 days
- life span-post-weaning/aging
- premature death (MGI Ref ID J:5634)
- 40% of mice that survive weaning die by 12 months
- hydrocephalus is observed in mice that die at an early age
- limbs/digits/tail phenotype
- abnormal paw/hand/foot morphology (MGI Ref ID J:5634)
- all hind foot digits curve progressively laterally or medially
- change in shape of hind feet during growth, first digit of hindfoot often becomes parallel to the second digit
- short limbs (MGI Ref ID J:5634)
- short tail (MGI Ref ID J:5634)
- frequent development of s-type curves
- growth/size phenotype
- postnatal slow weight gain (MGI Ref ID J:5634)
- from day 10 weight gain does not match control
- endocrine/exocrine gland phenotype
- abnormal thyroid parafollicular C-cells (MGI Ref ID J:5634)
- parafollicular cell density in thyroid is significantly increased during first three months
- homeostasis/metabolism phenotype
- hypophosphatemia (MGI Ref ID J:5634)
- serum phosphate levels average 30% below control
Csf1op/Csf1op
involves: C57BL/6
- reproductive system phenotype
- abnormal ovary morphology (MGI Ref ID J:38039)
- very few macrophages present in ovaries at all stages of cycle and follicular development
- abnormal proestrus (MGI Ref ID J:38039)
- mice fail to display the normal proestrous surge in circulating estradiol-17 beta
- abnormal superovulation (MGI Ref ID J:38039)
- this process resulted in significantly more females with no mating plug (34.6%) compared with superovulated heterozygous females (11.1%)
- decreased fertilization frequency (MGI Ref ID J:38039)
- only 50% of the mated superovulated mutant females produced fertilized ooctyes compared with 83.3% of the mated superovulated heterozygous females
- decreased ovulation frequency (MGI Ref ID J:38039)
- 20% of ovaries fail to undergo ovulation
- the ovulation rate is low for mice that do ovulate
- impaired embryo implantation (MGI Ref ID J:38039)
- lower number of implantations
- prolonged estrous cycle (MGI Ref ID J:38039)
- females reach estrus every 14 days compared with a normal approximately 5 day cycle
- subcutaneous adninistration of CSF-1 from birth restores a normal estrous cycle
- embryogenesis phenotype
- impaired embryo implantation (MGI Ref ID J:38039)
- lower number of implantations
- endocrine/exocrine gland phenotype
- abnormal ovary morphology (MGI Ref ID J:38039)
- very few macrophages present in ovaries at all stages of cycle and follicular development
- hematopoietic system phenotype
- abnormal osteoclast differentiation (MGI Ref ID J:12210)
- exogenous M-CSF enables normal osteoclast differentiation
- immune system phenotype
- abnormal osteoclast differentiation (MGI Ref ID J:12210)
- exogenous M-CSF enables normal osteoclast differentiation
- skeleton phenotype
- abnormal osteoclast differentiation (MGI Ref ID J:12210)
- exogenous M-CSF enables normal osteoclast differentiation
- behavior/neurological phenotype
- abnormal mating frequency (MGI Ref ID J:38039)
- only 64.4% of superovulated mutant females successfully mated as evidenced by a vaginal plug compared with 88.9% of mated superovulated heterozygous females
This mouse can be used to support research in many areas including:
Csf1op relatedNeurobiology Research
Alzheimer's Disease
Parkinson's Disease
Cancer Research
Growth Factors/Receptors/Cytokines
Developmental Biology Research
Skeletal Defects
osteopetrosis
Endocrine Deficiency Research
Bone/Bone Marrow Defects
Immunology and Inflammation Research
Growth Factors/Receptors/Cytokines
Immunodeficiency
Immunodeficiency Associated with Other Defects
Mouse/Human Gene Homologs
Infantile neuronal ceroid lipofuscinosis
Research Tools
Immunology and Inflammation Research
Macrophage Deficiency
Genes & Alleles
Gene & Allele Information
| Allele Symbol | Csf1op | ||
|---|---|---|---|
| Allele Name | osteopetrosis | ||
| Allele Type | Spontaneous | ||
| Common Name(s) | Csf-1op; Csf1<-> op; Csfmop; M-; csfmop; op; | ||
| Strain of Origin | B6;DW-Pou1f1 | ||
| Gene Symbol and Name | Csf1, colony stimulating factor 1 (macrophage) | ||
| Chromosome | 3 | ||
| Gene Common Name(s) | C87615; CSF-1; Csfm; M-CSF; MCSF; MGC31930; colony stimulating factor, macrophage; colony-stimulating factor-1; expressed sequence C87615; op; osteopetrosis; | ||
| General Note |
Occlusion of the marrow cavities in young Csf1op/Csf1op mice leads to reduced hemopoiesis in the marrow, accompanied by splenomegaly and prolonged splenic hemopoiesis. The bone marrow is, however, seeded with the requisite hemopoietic precursor cells; and the reduced hemopoiesis in marrow is not due to direct effects of M-CSF (J:19549). Macrophage populations derived from monocytes are absent in Csf1op homozygotes, but mature macrophages are produced from other precursors under the influence of granulocyte-macrophage colony stimulating factor (GM-CSF) (J:26978). Bone marrow macrophages arrest in G1 phase in M-CSF deficient mice; the factor regulates cyclins involved in commitment of cells to S phase (J:14776). Bacterial translocation and lipopolysaccharide-induced morbidity and mortality are no different in Csf1op/Csf1op mice than in normal littermates (J:20379). Low levels of cytokines involved in immune reactions, found in 6 week old Csf1op homozygotes, recover to normal in these mice at older ages, as the bone marrow macrophage population is restored to normal (J:18531). Macrophage deficiencies in Csf1op/Csf1op mutants do not prevent them mounting normal T cell responses to infection (J:24207). Intramuscular transplantation of myoblasts capable of producing M-CSF into Csf1op homozygotes introduces the factor into the circulation of the mutant mice along with macrophages, but only transiently.The induced M-CSF may have been bound by macrophages accumulating at the site of the transplant. Macrophages accumulate at the site of muscle damage due to transplantation or to control muscle insult, and the damage can be repaired in the osteopetrotic mice (J:38812). The low pregnancy rates and reduced litter sizes among Csf1op/Csf1op female mice arise from disruption of estrous cycles and of ovulation. Estrus cycle length is lengthened in these mice (J:38039). Numbers of ovulated ova in Fallopian tubules are decreased in mutant mice relative to wild-type. Antral and mature follicles in the proestrous ovary are also decreased, and the proliferative capacity of granulosa ccells in antral follicules is reduced, as are numbers of granulosa cells and macrophages. All of these functions can be increased by daily treatment with M-CSF (J:30863). Male mutant animals experience lowered levels of both circulating and testicular testosterone, accompanied by reduced mating capacity and lowered numbers of viable sperm (J:34371). Csf1op/Csf1op females also are incapable of feeding any pups they may bear. Mammary gland ductal growth is incomplete during pregnancy, and the mice fail to switch to a lactational state after parturition, despite the presence of milk proteins (J:20519). Brain cytoarchitectural abnormalities are not found in Csf1op homozygotes (J:19249), and microglia in these mice are normal in number and morphology (J:23600). Vulnerability of neurons to ischemic injury is increased, and the microglial response to neuronal injury reduced, in Csf1op homozygotes (J:30212). Electrophysiologic assay of mutant mice revealed abnormal auditory and visual evoked potentials and other signs of aberrant neuronal function (J:35818). | ||
| Molecular Note | A single nucleotide (T) insertion 262 bp downstream from the initiation codon resulted in a frameshift and the creation of a stop codon 21 bp downstream of the insertion. [MGI Ref ID J:10519] | ||
| Allele Symbol | a | ||
| Allele Name | nonagouti | ||
| Allele Type | Spontaneous | ||
Genotyping
Genotyping Information
This strain will not have a genotyping protocol or one is not currently available.
Helpful Links
Genotyping resources and troubleshooting
References
References
Additional References
Bruhns P; Samuelsson A; Pollard JW; Ravetch JV. 2003. Colony-stimulating factor-1-dependent macrophages are responsible for IVIG protection in antibody-induced autoimmune disease. Immunity 18(4):573-81. [PubMed: 12705859] [MGI Ref ID J:83013]
Ida-Yonemochi H; Noda T; Shimokawa H; Saku T. 2002. Disturbed tooth eruption in osteopetrotic (op/op) mice: histopathogenesis of tooth malformation and odontomas. J Oral Pathol Med 31(6):361-73. [PubMed: 12201247] [MGI Ref ID J:78487]
Kaku M; Tsutsui K; Motokawa M; Kawata T; Fujita T; Kohno S; Tohma Y; Ohtani J; Tenjoh K; Tanne K. 2003. Amyloid beta protein deposition and neuron loss in osteopetrotic (op/op) mice. Brain Res Brain Res Protoc 12(2):104-8. [PubMed: 14613812] [MGI Ref ID J:87261]
Lenda DM; Kikawada E; Stanley ER; Kelley VR. 2003. Reduced macrophage recruitment, proliferation, and activation in colony-stimulating factor-1-deficient mice results in decreased tubular apoptosis during renal inflammation. J Immunol 170(6):3254-62. [PubMed: 12626584] [MGI Ref ID J:82301]
Lenda DM; Stanley ER; Kelley VR. 2004. Negative role of colony-stimulating factor-1 in macrophage, T cell, and B cell mediated autoimmune disease in MRL-Fas(lpr) mice. J Immunol 173(7):4744-54. [PubMed: 15383612] [MGI Ref ID J:93714]
Naito M; Hayashi S; Yoshida H; Nishikawa S; Shultz LD; Takahashi K. 1991. Abnormal differentiation of tissue macrophage populations in 'osteopetrosis' (op) mice defective in the production of macrophage colony-stimulating factor. Am J Pathol 139(3):657-67. [PubMed: 1887865] [MGI Ref ID J:26978]
Sasaki A; Yokoo H; Naito M; Kaizu C; Shultz LD; Nakazato Y. 2000. Effects of macrophage-colony-stimulating factor deficiency on the maturation of microglia and brain macrophages and on their expression of scavenger receptor. Neuropathology 20(2):134-42. [PubMed: 10935450] [MGI Ref ID J:82594]
Tagaya H; Kunisada T; Yamazaki H; Yamane T; Tokuhisa T; Wagner EF; Sudo T; Shultz LD; Hayashi SI. 2000. Intramedullary and extramedullary B lymphopoiesis in osteopetrotic mice. Blood 95(11):3363-70. [PubMed: 10828017] [MGI Ref ID J:82593]
Yoshida H; Hayashi S; Kunisada T; Ogawa M; Nishikawa S; Okamura H; Sudo T; Shultz LD; Nishikawa S. 1990. The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor gene. Nature 345(6274):442-4. [PubMed: 2188141] [MGI Ref ID J:10519]
Csf1op relatedAbboud SL; Woodruff K; Liu C; Shen V; Ghosh-Choudhury N. 2002. Rescue of the osteopetrotic defect in op/op mice by osteoblast-specific targeting of soluble colony-stimulating factor-1. Endocrinology 143(5):1942-9. [PubMed: 11956177] [MGI Ref ID J:76327]
Alnaeeli M; Penninger JM; Teng YT. 2006. Immune interactions with CD4+ T cells promote the development of functional osteoclasts from murine CD11c+ dendritic cells. J Immunol 177(5):3314-26. [PubMed: 16920972] [MGI Ref ID J:139526]
Araki M; Fukumatsu Y; Katabuchi H; Shultz LD; Takahashi K; Okamura H. 1996. Follicular development and ovulation in macrophage colony-stimulating factor-deficient mice homozygous for the osteopetrosis (op) mutation. Biol Reprod 54(2):478-84. [PubMed: 8788202] [MGI Ref ID J:30863]
Banaei-Bouchareb L; Gouon-Evans V; Samara-Boustani D; Castellotti MC; Czernichow P; Pollard JW; Polak M. 2004. Insulin cell mass is altered in Csf1op/Csf1op macrophage-deficient mice. J Leukoc Biol 76(2):359-67. [PubMed: 15178709] [MGI Ref ID J:91463]
Baran CP; Opalek JM; McMaken S; Newland CA; O'Brien JM Jr; Hunter MG; Bringardner BD; Monick MM; Brigstock DR; Stromberg PC; Hunninghake GW; Marsh CB. 2007. Important roles for macrophage colony-stimulating factor, CC chemokine ligand 2, and mononuclear phagocytes in the pathogenesis of pulmonary fibrosis. Am J Respir Crit Care Med 176(1):78-89. [PubMed: 17431224] [MGI Ref ID J:147697]
Batchelor PE; Porritt MJ; Nilsson SK; Bertoncello I; Donnan GA; Howells DW. 2002. Periwound dopaminergic sprouting is dependent on numbers of wound macrophages. Eur J Neurosci 15(5):826-32. [PubMed: 11906524] [MGI Ref ID J:107999]
Begg SK; Radley JM; Pollard JW; Chisholm OT; Stanley ER; Bertoncello I. 1993. Delayed hematopoietic development in osteopetrotic (op/op) mice. J Exp Med 177(1):237-42. [PubMed: 8418205] [MGI Ref ID J:3480]
Berezovskaya O; Maysinger D; Fedoroff S. 1995. The hematopoietic cytokine, colony-stimulating factor 1, is also a growth factor in the CNS: congenital absence of CSF-1 in mice results in abnormal microglial response and increased neuron vulnerability to injury. Int J Dev Neurosci 13(3-4):285-99. [PubMed: 7572282] [MGI Ref ID J:30212]
Bergmann CE; Hoefer IE; Meder B; Roth H; van Royen N; Breit SM; Jost MM; Aharinejad S; Hartmann S; Buschmann IR. 2006. Arteriogenesis depends on circulating monocytes and macrophage accumulation and is severely depressed in op/op mice. J Leukoc Biol 80(1):59-65. [PubMed: 16684892] [MGI Ref ID J:110465]
Blevins G; Fedoroff S. 1995. Microglia in colony-stimulating factor 1-deficient op/op mice. J Neurosci Res 40(4):535-44. [PubMed: 7616613] [MGI Ref ID J:23600]
Brown NJ; Hutcheson J; Bickel E; Scatizzi JC; Albee LD; Haines GK rd; Eslick J; Bradley K; Taricone E; Perlman H. 2004. Fas death receptor signaling represses monocyte numbers and macrophage activation in vivo. J Immunol 173(12):7584-93. [PubMed: 15585886] [MGI Ref ID J:94851]
Bruhns P; Samuelsson A; Pollard JW; Ravetch JV. 2003. Colony-stimulating factor-1-dependent macrophages are responsible for IVIG protection in antibody-induced autoimmune disease. Immunity 18(4):573-81. [PubMed: 12705859] [MGI Ref ID J:83013]
Carenini S; Maurer M; Werner A; Blazyca H; Toyka KV; Schmid CD; Raivich G; Martini R. 2001. The role of macrophages in demyelinating peripheral nervous system of mice heterozygously deficient in p0. J Cell Biol 152(2):301-8. [PubMed: 11266447] [MGI Ref ID J:67581]
Cecchini MG; Dominguez MG; Mocci S; Wetterwald A; Felix R; Fleisch H; Chisholm O; Hofstetter W; Pollard JW; Stanley ER. 1994. Role of colony stimulating factor-1 in the establishment and regulation of tissue macrophages during postnatal development of the mouse. Development 120(6):1357-72. [PubMed: 8050349] [MGI Ref ID J:18915]
Chang MD; Stanley ER; Khalili H; Chisholm O; Pollard JW. 1995. Osteopetrotic (op/op) mice deficient in macrophages have the ability to mount a normal T-cell-dependent immune response. Cell Immunol 162(1):146-52. [PubMed: 7704903] [MGI Ref ID J:24207]
Chang Y; Albright S; Lee F. 1994. Cytokines in the central nervous system: expression of macrophage colony stimulating factor and its receptor during development. J Neuroimmunol 52(1):9-17. [PubMed: 8207122] [MGI Ref ID J:19249]
Clohisy DR; Ramnaraine ML. 1997. Osteoclast formation during tumor osteolysis does not require proliferating osteoclast precursor cells. J Orthop Res 15(2):301-6. [PubMed: 9167635] [MGI Ref ID J:41527]
Clynes R; Ravetch JV. 1995. Cytotoxic antibodies trigger inflammation through Fc receptors. Immunity 3(1):21-6. [PubMed: 7621075] [MGI Ref ID J:78887]
Cohen PE; Chisholm O; Arceci RJ; Stanley ER; Pollard JW. 1996. Absence of colony-stimulating factor-1 in osteopetrotic (csfmop/csfmop) mice results in male fertility defects. Biol Reprod 55(2):310-7. [PubMed: 8828834] [MGI Ref ID J:34371]
Cohen PE; Hardy MP; Pollard JW. 1997. Colony-stimulating factor-1 plays a major role in the development of reproductive function in male mice. Mol Endocrinol 11(11):1636-50. [PubMed: 9328346] [MGI Ref ID J:43181]
Cohen PE; Zhu L; Pollard JW. 1997. Absence of colony stimulating factor-1 in osteopetrotic (csfmop/csfmop) mice disrupts estrous cycles and ovulation. Biol Reprod 56(1):110-8. [PubMed: 9002639] [MGI Ref ID J:38039]
D'Errico JA; MacNeil RL; Strayhorn CL; Piotrowski BT; Somerman MJ. 1995. Models for the study of cementogenesis. Connect Tissue Res 33(1-3):9-17. [PubMed: 7554968] [MGI Ref ID J:30202]
Dai XM; Ryan GR; Hapel AJ; Dominguez MG; Russell RG; Kapp S; Sylvestre V; Stanley ER. 2002. Targeted disruption of the mouse colony-stimulating factor 1 receptor gene results in osteopetrosis, mononuclear phagocyte deficiency, increased primitive progenitor cell frequencies, and reproductive defects. Blood 99(1):111-20. [PubMed: 11756160] [MGI Ref ID J:73663]
Dai XM; Zong XH; Sylvestre V; Stanley ER. 2004. Incomplete restoration of colony-stimulating factor 1 (CSF-1) function in CSF-1-deficient Csf1op/Csf1op mice by transgenic expression of cell surface CSF-1. Blood 103(3):1114-23. [PubMed: 14525772] [MGI Ref ID J:87641]
De Ciuceis C; Amiri F; Brassard P; Endemann DH; Touyz RM; Schiffrin EL. 2005. Reduced vascular remodeling, endothelial dysfunction, and oxidative stress in resistance arteries of angiotensin II-infused macrophage colony-stimulating factor-deficient mice: evidence for a role in inflammation in angiotensin-induced vascular injury. Arterioscler Thromb Vasc Biol 25(10):2106-13. [PubMed: 16100037] [MGI Ref ID J:114425]
Deckers MM; Van Beek ER; Van Der Pluijm G; Wetterwald A; Van Der Wee-Pals L; Cecchini MG; Papapoulos SE; Lowik CW. 2002. Dissociation of angiogenesis and osteoclastogenesis during endochondral bone formation in neonatal mice. J Bone Miner Res 17(6):998-1007. [PubMed: 12054176] [MGI Ref ID J:112373]
Dhawan J; Rando TA; Elson SE; Lee F; Stanley ER; Blau HM. 1996. Myoblast-mediated expression of colony stimulating factor-1 (CSF-1) in the cytokine-deficient op/op mouse. Somat Cell Mol Genet 22(5):363-81. [PubMed: 9039846] [MGI Ref ID J:38812]
Felix R; Cecchini MG; Fleisch H. 1990. Macrophage colony stimulating factor restores in vivo bone resorption in the op/op osteopetrotic mouse. Endocrinology 127(5):2592-4. [PubMed: 2146111] [MGI Ref ID J:10799]
Felix R; Hofstetter W; Wetterwald A; Cecchini MG; Fleisch H. 1994. Role of colony-stimulating factor-1 in bone metabolism. J Cell Biochem 55(3):340-9. [PubMed: 7962166] [MGI Ref ID J:19367]
Feltis BA; Jechorek RP; Erlandsen SL; Wells CL. 1994. Bacterial translocation and lipopolysaccharide-induced mortality in genetically macrophage-deficient op/op mice. Shock 2(1):29-33. [PubMed: 7735981] [MGI Ref ID J:20379]
Galeazzi F; Lovato P; Blennerhassett PA; Haapala EM; Vallance BA; Collins SM. 2001. Neural change in Trichinella-infected mice is MHC II independent and involves M-CSF-derived macrophages. Am J Physiol Gastrointest Liver Physiol 281(1):G151-8. [PubMed: 11408267] [MGI Ref ID J:107859]
Ghia JE; Blennerhassett P; El-Sharkawy RT; Collins SM. 2007. The protective effect of the vagus nerve in a murine model of chronic relapsing colitis. Am J Physiol Gastrointest Liver Physiol 293(4):G711-8. [PubMed: 17673544] [MGI Ref ID J:126720]
Ghia JE; Galeazzi F; Ford DC; Hogaboam CM; Vallance BA; Collins S. 2008. Role of M-CSF-dependent macrophages in colitis is driven by the nature of the inflammatory stimulus. Am J Physiol Gastrointest Liver Physiol 294(3):G770-7. [PubMed: 18202111] [MGI Ref ID J:132596]
Ginhoux F; Tacke F; Angeli V; Bogunovic M; Loubeau M; Dai XM; Stanley ER; Randolph GJ; Merad M. 2006. Langerhans cells arise from monocytes in vivo. Nat Immunol 7(3):265-73. [PubMed: 16444257] [MGI Ref ID J:112594]
Gouon-Evans V; Rothenberg ME; Pollard JW. 2000. Postnatal mammary gland development requires macrophages and eosinophils. Development 127(11):2269-82. [PubMed: 10804170] [MGI Ref ID J:110688]
Guleria I; Pollard JW. 2001. Aberrant macrophage and neutrophil population dynamics and impaired Th1 response to Listeria monocytogenes in colony-stimulating factor 1-deficient mice. Infect Immun 69(3):1795-807. [PubMed: 11179357] [MGI Ref ID J:67608]
Guleria I; Pollard JW. 2000. The trophoblast is a component of the innate immune system during pregnancy. Nat Med 6(5):589-93. [PubMed: 10802718] [MGI Ref ID J:119170]
Hume DA; Favot P. 1995. Is the osteopetrotic (op/op mutant) mouse completely deficient in expression of macrophage colony-stimulating factor? J Interferon Cytokine Res 15(4):279-84. [PubMed: 7627801] [MGI Ref ID J:25708]
Hunt JS; Chen HL; Hu XL; Pollard JW. 1993. Normal distribution of tumor necrosis factor-alpha messenger ribonucleic acid and protein in the uteri, placentas, and embryos of osteopetrotic (op/op) mice lacking colony-stimulating factor-1. Biol Reprod 49(3):441-52. [PubMed: 8399834] [MGI Ref ID J:14542]
Ida-Yonemochi H; Noda T; Shimokawa H; Saku T. 2002. Disturbed tooth eruption in osteopetrotic (op/op) mice: histopathogenesis of tooth malformation and odontomas. J Oral Pathol Med 31(6):361-73. [PubMed: 12201247] [MGI Ref ID J:78487]
Ingman WV; Wyckoff J; Gouon-Evans V; Condeelis J; Pollard JW. 2006. Macrophages promote collagen fibrillogenesis around terminal end buds of the developing mammary gland. Dev Dyn 235(12):3222-9. [PubMed: 17029292] [MGI Ref ID J:116644]
Jang MH; Herber DM; Jiang X; Nandi S; Dai XM; Zeller G; Stanley ER; Kelley VR. 2006. Distinct in vivo roles of colony-stimulating factor-1 isoforms in renal inflammation. J Immunol 177(6):4055-63. [PubMed: 16951369] [MGI Ref ID J:138044]
Kaku M; Kawata T; Kawasoko S; Fujita T; Tokimasa C; Niida S; Tanne K. 1998. Osteoclast appearance in developmental stages of different bones after a single injection of macrophage colony- stimulating factor in op/op mice. Biomed Res 19(1):77-81. [MGI Ref ID J:47075]
Kaku M; Kawata T; Kawasoko S; Fujita T; Tokimasa C; Tanne K. 1999. Remodeling of the sagittal suture in osteopetrotic (op/op) mice associated with cranial flat bone growth. J Craniofac Genet Dev Biol 19(2):109-12. [PubMed: 10416154] [MGI Ref ID J:58056]
Kaku M; Tsutsui K; Motokawa M; Kawata T; Fujita T; Kohno S; Tohma Y; Ohtani J; Tenjoh K; Tanne K. 2003. Amyloid beta protein deposition and neuron loss in osteopetrotic (op/op) mice. Brain Res Brain Res Protoc 12(2):104-8. [PubMed: 14613812] [MGI Ref ID J:87261]
Kalla R; Liu Z; Xu S; Koppius A; Imai Y; Kloss CU; Kohsaka S; Gschwendtner A; Moller JC; Werner A; Raivich G. 2001. Microglia and the early phase of immune surveillance in the axotomized facial motor nucleus: Impaired microglial activation and lymphocyte recruitment but no effect on neuronal survival or axonal regeneration in macrophage-colony stimulating factor-deficient mice. J Comp Neurol 436(2):182-201. [PubMed: 11438923] [MGI Ref ID J:70370]
Karlsson MC; Guinamard R; Bolland S; Sankala M; Steinman RM; Ravetch JV. 2003. Macrophages control the retention and trafficking of B lymphocytes in the splenic marginal zone. J Exp Med 198(2):333-40. [PubMed: 12874264] [MGI Ref ID J:119256]
Kawata T; Fujita T; Tokimasa C; Sugiyama H; Ozawa S; Tanne K. 2001. Analysis of histochemically and morphometrically in the anterior belly digastric muscle of osteopetrotic (op/op) mice. Exp Anim 50(2):133-8. [PubMed: 11381616] [MGI Ref ID J:69954]
Kawata T; Kawasoko S; Kaku M; Fujita T; Tokimasa C; Niida S ; Tanne K. 1999. Recruitment of osteoclasts in the mandibular condyle of growing osteopetrotic (op/op) mice after a single injection of macrophage colony-stimulating factor. Arch Oral Biol 44(1):81-8. [PubMed: 10075153] [MGI Ref ID J:53698]
Kawata T; Tokimasa C; Fujita T; Kaku M; Kawasoko S; Sugiyama H ; Ozawa S ; Tanne K. 1999. Morphological change of the nasopremaxillary suture in growing toothless osteopetrotic (op/op) mice. J Craniofac Genet Dev Biol 19(1):48-55. [PubMed: 10378148] [MGI Ref ID J:55462]
Kawata T; Tokimasa C; Fujita T; Kawasoko S; Kaku M; Sugiyama H; Tanne K. 1998. Midpalatal suture of osteopetrotic (op/op) mice exhibits immature fusion. Exp Anim 47(4):277-81. [PubMed: 10067173] [MGI Ref ID J:51854]
Kawata T; Tokimasa C; Fujita T; Ozawa S; Sugiyama H; Tanne K. 1999. Facial skeletal growth in growing 'toothless' osteopetrotic (op/op) mice: radiographic findings J Craniofac Genet Dev Biol 19(4):221-5. [PubMed: 10731091] [MGI Ref ID J:61237]
Kawata T; Tokimasa C; Nowroozi N; Fujita T; Kaku M; Kawasoko S ; Sugiyama H ; Ozawa S ; Zernik JH ; Tanne K. 1999. Lack of the bone remodeling in osteopetrotic (op/op) mice associated with microdontia. J Craniofac Genet Dev Biol 19(2):113-7. [PubMed: 10416155] [MGI Ref ID J:56255]
Kawata T; Zernik JH; Fujita T; Tokimasa C; Tanne K. 1999. Mechanism in inhibitory effects of vitamin K2 on osteoclastic bone resorption: in vivo study in osteopetrotic (op/op) mice. J Nutr Sci Vitaminol (Tokyo) 45(4):501-7. [PubMed: 10575640] [MGI Ref ID J:59641]
Kim EY; Battaile JT; Patel AC; You Y; Agapov E; Grayson MH; Benoit LA; Byers DE; Alevy Y; Tucker J; Swanson S; Tidwell R; Tyner JW; Morton JD; Castro M; Polineni D; Patterson GA; Schwendener RA; Allard JD; Peltz G; Holtzman MJ. 2008. Persistent activation of an innate immune response translates respiratory viral infection into chronic lung disease. Nat Med 14(6):633-40. [PubMed: 18488036] [MGI Ref ID J:136947]
Kiso Y; Pollard JW; Croy BA. 1992. A study of granulated metrial gland cell differentiation in pregnant, macrophage-deficient, osteopetrotic (op/op) mice. Experientia 48(10):973-5. [PubMed: 1426147] [MGI Ref ID J:3619]
Ko EA; Amiri F; Pandey NR; Javeshghani D; Leibovitz E; Touyz RM; Schiffrin EL. 2007. Resistance artery remodeling in deoxycorticosterone acetate-salt hypertension is dependent on vascular inflammation: evidence from m-CSF-deficient mice. Am J Physiol Heart Circ Physiol 292(4):H1789-95. [PubMed: 17142347] [MGI Ref ID J:125825]
Kobayashi M; Masuda Y; Kishino M; Ishida T; Maeda N; Morimoto T. 2002. Characteristics of mastication in the anodontic mouse. J Dent Res 81(9):594-7. [PubMed: 12202638] [MGI Ref ID J:105926]
Kodama H; Yamasaki A; Abe M; Niida S; Hakeda Y; Kawashima H. 1993. Transient recruitment of osteoclasts and expression of their function in osteopetrotic (op/op) mice by a single injection of macrophage colony-stimulating factor. J Bone Miner Res 8(1):45-50. [PubMed: 8427048] [MGI Ref ID J:4732]
Kodama I; Niida S; Sanada M; Yoshiko Y; Tsuda M; Maeda N; Ohama K. 2004. Estrogen regulates the production of VEGF for osteoclast formation and activity in op/op mice. J Bone Miner Res 19(2):200-6. [PubMed: 14969389] [MGI Ref ID J:111232]
Kondo Y; Lemere CA; Seabrook TJ. 2007. Osteopetrotic (op/op) mice have reduced microglia, no Abeta deposition, and no changes in dopaminergic neurons. J Neuroinflammation 4:31. [PubMed: 18093340] [MGI Ref ID J:132962]
Kubota Y; Takubo K; Shimizu T; Ohno H; Kishi K; Shibuya M; Saya H; Suda T. 2009. M-CSF inhibition selectively targets pathological angiogenesis and lymphangiogenesis. J Exp Med 206(5):1089-102. [PubMed: 19398755] [MGI Ref ID J:148497]
Lagasse E; Weissman IL. 1997. Enforced expression of Bcl-2 in monocytes rescues macrophages and partially reverses osteopetrosis in op/op mice. Cell 89(7):1021-31. [PubMed: 9215625] [MGI Ref ID J:41240]
Lane PW. 1973. Osteopetrosis (op) Mouse News Lett 48:35. [MGI Ref ID J:35678]
Lenda DM; Kikawada E; Stanley ER; Kelley VR. 2003. Reduced macrophage recruitment, proliferation, and activation in colony-stimulating factor-1-deficient mice results in decreased tubular apoptosis during renal inflammation. J Immunol 170(6):3254-62. [PubMed: 12626584] [MGI Ref ID J:82301]
Lenda DM; Stanley ER; Kelley VR. 2004. Negative role of colony-stimulating factor-1 in macrophage, T cell, and B cell mediated autoimmune disease in MRL-Fas(lpr) mice. J Immunol 173(7):4744-54. [PubMed: 15383612] [MGI Ref ID J:93714]
Li J; Chen K; Zhu L; Pollard JW. 2006. Conditional deletion of the colony stimulating factor-1 receptor (c-fms proto-oncogene) in mice. Genesis 44(7):328-35. [PubMed: 16823860] [MGI Ref ID J:110981]
Lieschke GJ; Stanley E; Grail D; Hodgson G; Sinickas V; Gall JA; Sinclair RA; Dunn AR. 1994. Mice lacking both macrophage- and granulocyte-macrophage colony-stimulating factor have macrophages and coexistent osteopetrosis and severe lung disease. Blood 84(1):27-35. [PubMed: 8018921] [MGI Ref ID J:19089]
Lin EY; Li JF; Bricard G; Wang W; Deng Y; Sellers R; Porcelli SA; Pollard JW. 2007. VEGF Restores Delayed Tumor Progression in Tumors Depleted of Macrophages. Mol Oncol 1(3):288-302. [PubMed: 18509509] [MGI Ref ID J:138643]
Lin EY; Li JF; Gnatovskiy L; Deng Y; Zhu L; Grzesik DA; Qian H; Xue XN; Pollard JW. 2006. Macrophages regulate the angiogenic switch in a mouse model of breast cancer. Cancer Res 66(23):11238-46. [PubMed: 17114237] [MGI Ref ID J:116132]
Lin EY; Nguyen AV; Russell RG; Pollard JW. 2001. Colony-stimulating factor 1 promotes progression of mammary tumors to malignancy. J Exp Med 193(6):727-40. [PubMed: 11257139] [MGI Ref ID J:68146]
Lin EY; Pollard JW. 2004. Macrophages: modulators of breast cancer progression. Novartis Found Symp 256:158-68; discussion 168-72, 259. [PubMed: 15027489] [MGI Ref ID J:90229]
Lomas-Neira J; Chung CS; Perl M; Gregory S; Biffl W; Ayala A. 2006. Role of alveolar macrophage and migrating neutrophils in hemorrhage-induced priming for ALI subsequent to septic challenge. Am J Physiol Lung Cell Mol Physiol 290(1):L51-8. [PubMed: 16157517] [MGI Ref ID J:104798]
Loureiro RM; Monaco KA; Kearney JB; Blickarz-Durand CE; Kirby SL; Inamdar MS; Bautch VL. 2008. csf1 is required for early embryonic macrophage development: characterization of the csf1(op)/csf1(op) mutation in ES cell-derived macrophages. Br J Haematol 141(5):739-42. [PubMed: 18422785] [MGI Ref ID J:141708]
Lu L; Osmond DG. 2001. Regulation of cell survival during B lymphopoiesis in mouse bone marrow: enhanced pre-B-cell apoptosis in CSF-1-deficient op/op mutant mice. Exp Hematol 29(5):596-601. [PubMed: 11376872] [MGI Ref ID J:69425]
Mackler AM; Barber EM; Takikawa O; Pollard JW. 2003. Indoleamine 2,3-dioxygenase is regulated by IFN-gamma in the mouse placenta during Listeria monocytogenes infection. J Immunol 170(2):823-30. [PubMed: 12517946] [MGI Ref ID J:127135]
Maeda N; Kawata T; Yoshiko Y; Hosoi M; Suemune S; Okada N; Tanne K. 1994. Postnatal changes in the masseter muscle of the toothless (op/op) mouse with less-developed periodontal ligaments. Biomed Res 15(4):255-261. [MGI Ref ID J:20589]
Marks SC Jr; Iizuka T; MacKay CA; Mason-Savas A; Cielinski MJ. 1997. The effects of colony-stimulating factor-1 on the number and ultrastructure of osteoclasts in toothless (tl) rats and osteopetrotic (op) mice. Tissue Cell 29(5):589-95. [PubMed: 9364807] [MGI Ref ID J:44590]
Marks SC Jr; Lane PW. 1976. Osteopetrosis, a new recessive skeletal mutation on chromosome 12 of the mouse. J Hered 67(1):11-18. [PubMed: 1262696] [MGI Ref ID J:5634]
McCary LC; DeLuca HF. 1996. Osteopetrotic (op/op) mice are unable to maintain serum calcium levels despite hyperabsorption of calcium. Endocrinology 137(3):1049-56. [PubMed: 8603573] [MGI Ref ID J:31874]
McCary LC; Smith CM; DeLuca HF. 1997. Hypophosphatemia and the development of rickets in osteopetrotic (op/op) mice. J Bone Miner Res 12(11):1944-51. [PubMed: 9383699] [MGI Ref ID J:44543]
McCary LC; Staun M; DeLuca HF. 1999. A characterization of vitamin D-independent intestinal calcium absorption in the osteopetrotic (op/op) mouse. Arch Biochem Biophys 368(2):249-56. [PubMed: 10441375] [MGI Ref ID J:56835]
Menke J; Hsu MY; Byrne KT; Lucas JA; Rabacal WA; Croker BP; Zong XH; Stanley ER; Kelley VR. 2008. Sunlight triggers cutaneous lupus through a CSF-1-dependent mechanism in MRL-Fas(lpr) mice. J Immunol 181(10):7367-79. [PubMed: 18981160] [MGI Ref ID J:141073]
Michaelson MD; Bieri PL; Mehler MF; Xu H; Arezzo JC; Pollard JW; Kessler JA. 1996. CSF-1 deficiency in mice results in abnormal brain development. Development 122(9):2661-72. [PubMed: 8787741] [MGI Ref ID J:35818]
Mikkelsen HB; Thuneberg L. 1999. Op/op mice defective in production of functional colony-stimulating factor-1 lack macrophages in muscularis externa of the small intestine. Cell Tissue Res 295(3):485-93. [PubMed: 10022968] [MGI Ref ID J:53792]
Moayeri M; Martinez NW; Wiggins J; Young HA; Leppla SH. 2004. Mouse susceptibility to anthrax lethal toxin is influenced by genetic factors in addition to those controlling macrophage sensitivity. Infect Immun 72(8):4439-47. [PubMed: 15271901] [MGI Ref ID J:91775]
Mueller CG; Cremer I; Paulet PE; Niida S; Maeda N; Lebeque S; Fridman WH; Sautes-Fridman C. 2001. Mannose receptor ligand-positive cells express the metalloprotease decysin in the B cell follicle. J Immunol 167(9):5052-60. [PubMed: 11673514] [MGI Ref ID J:67032]
Mullaly SC; Kubes P. 2006. The role of TLR2 in vivo following challenge with Staphylococcus aureus and prototypic ligands. J Immunol 177(11):8154-63. [PubMed: 17114491] [MGI Ref ID J:140680]
Muller M; Berghoff M; Kobsar I; Kiefer R; Martini R. 2007. Macrophage colony stimulating factor is a crucial factor for the intrinsic macrophage response in mice heterozygously deficient for the myelin protein P0. Exp Neurol 203(1):55-62. [PubMed: 16962581] [MGI Ref ID J:141511]
Murase S; Hayashi Y. 1998. Expression pattern and neurotrophic role of the c-fms proto-oncogene M-CSF receptor in rodent Purkinje cells. J Neurosci 18(24):10481-92. [PubMed: 9852586] [MGI Ref ID J:52174]
Myint YY; Miyakawa K; Naito M; Shultz LD; Oike Y; Yamamura K; Takahashi K. 1999. Granulocyte/macrophage colony-stimulating factor and interleukin-3 correct osteopetrosis in mice with osteopetrosis mutation. Am J Pathol 154(2):553-66. [PubMed: 10027413] [MGI Ref ID J:52817]
Nagahama SI; Cunningham ML; Lee MY; Byers MR. 1998. Normal development of dental innervation and nerve/tissue interactions in the colony-stimulating factor-1 deficient osteopetrotic mouse. Dev Dyn 211(1):52-9. [PubMed: 9438423] [MGI Ref ID J:45196]
Naito M; Hayashi S; Yoshida H; Nishikawa S; Shultz LD; Takahashi K. 1991. Abnormal differentiation of tissue macrophage populations in 'osteopetrosis' (op) mice defective in the production of macrophage colony-stimulating factor. Am J Pathol 139(3):657-67. [PubMed: 1887865] [MGI Ref ID J:26978]
Naito M; Umeda S; Takahashi K; Shultz LD. 1997. Macrophage differentiation and granulomatous inflammation in osteopetrotic mice (op/op) defective in the production of CSF-1. Mol Reprod Dev 46(1):85-91. [PubMed: 8981368] [MGI Ref ID J:37427]
Nandi S; Akhter MP; Seifert MF; Dai XM; Stanley ER. 2006. Developmental and functional significance of the CSF-1 proteoglycan chondroitin sulfate chain. Blood 107(2):786-95. [PubMed: 16210339] [MGI Ref ID J:126635]
Neugarten J; Feith GW; Assmann KJ; Shan Z; Stanley ER; Schlondorff D. 1995. Role of macrophages and colony-stimulating factor-1 in murine antiglomerular basement membrane glomerulonephritis. J Am Soc Nephrol 5(11):1903-9. [PubMed: 7542490] [MGI Ref ID J:26586]
Ngo VN; Korner H; Gunn MD; Schmidt KN; Riminton DS; Cooper MD; Browning JL; Sedgwick JD; Cyster JG. 1999. Lymphotoxin alpha/beta and tumor necrosis factor are required for stromal cell expression of homing chemokines in B and T cell areas of the spleen. J Exp Med 189(2):403-12. [PubMed: 9892622] [MGI Ref ID J:52941]
Niida S; Abe M; Suemune S; Yoshiko Y; Maeda N; Yamasaki A. 1997. Restoration of disturbed tooth eruption in osteopetrotic (op/op) mice by injection of macrophage colony-stimulating factor. Exp Anim 46(2):95-101. [PubMed: 9145288] [MGI Ref ID J:40564]
Niida S; Kondo T; Hiratsuka S; Hayashi S; Amizuka N; Noda T; Ikeda K; Shibuya M. 2005. VEGF receptor 1 signaling is essential for osteoclast development and bone marrow formation in colony-stimulating factor 1-deficient mice. Proc Natl Acad Sci U S A 102(39):14016-21. [PubMed: 16172397] [MGI Ref ID J:101408]
Niida S; Wakisaka H; Kanno E; Yamasaki A. 1994. Cranial flat bone formation in the osteopetrotic (Op/Op) mouse Biomed Res 15(1):37-44. [MGI Ref ID J:18356]
Nilsson SK; Bertoncello I. 1994. Age-related changes in extramedullary hematopoiesis in the spleen of normal and perturbed osteopetrotic (op/op) mice [published erratum appears in Exp Hematol 1994 Jun;22(6):527-8] Exp Hematol 22(4):377-83. [PubMed: 8150037] [MGI Ref ID J:17699]
Nilsson SK; Bertoncello I. 1994. The development and establishment of hemopoiesis in fetal and newborn osteopetrotic (op/op) mice. Dev Biol 164(2):456-62. [PubMed: 8045348] [MGI Ref ID J:19549]
Nilsson SK; Lieschke GJ; Garcia-Wijnen CC; Williams B; Tzelepis D; Hodgson G; Grail D; Dunn AR; Bertoncello I. 1995. Granulocyte-macrophage colony-stimulating factor is not responsible for the correction of hematopoietic deficiencies in the maturing op/op mouse. Blood 86(1):66-72. [PubMed: 7795257] [MGI Ref ID J:26516]
Nishino I; Amizuka N; Ozawa H. 2001. Histochemical examination of osteoblastic activity in op/op mice with or without injection of recombinant M-CSF. J Bone Miner Metab 19(5):267-76. [PubMed: 11498728] [MGI Ref ID J:117405]
Nishioji K; Okanoue T; Mori T; Sakamoto S; Itoh Y. 1999. Experimental liver injury induced by Propionibacterium acnes and lipopolysaccharide in macrophage colony stimulating factor-deficient osteopetrotic (op/op) mice. Dig Dis Sci 44(10):1975-84. [PubMed: 10548345] [MGI Ref ID J:59689]
Nowicki A; Szenajch J; Ostrowska G; Wojtowicz A; Wojtowicz K; Kruszewski AA; Maruszynski M; Aukerman SL; Wiktor-Jedrzejczak W. 1996. Impaired tumor growth in colony-stimulating factor 1 (CSF-1)-deficient, macrophage-deficient op/op mouse: evidence for a role of CSF-1-dependent macrophages in formation of tumor stroma. Int J Cancer 65(1):112-9. [PubMed: 8543387] [MGI Ref ID J:31373]
Oguma K; Oshima H; Aoki M; Uchio R; Naka K; Nakamura S; Hirao A; Saya H; Taketo MM; Oshima M. 2008. Activated macrophages promote Wnt signalling through tumour necrosis factor-alpha in gastric tumour cells. EMBO J 27(12):1671-81. [PubMed: 18511911] [MGI Ref ID J:137013]
Ovadia S; Insogna K; Yao GQ. 2006. The cell-surface isoform of colony stimulating factor 1 (CSF1) restores but does not completely normalize fecundity in CSF1-deficient mice. Biol Reprod 74(2):331-6. [PubMed: 16237150] [MGI Ref ID J:105388]
Owens GC; Bunge RP. 1991. Schwann cells infected with a recombinant retrovirus expressing myelin-associated glycoprotein antisense RNA do not form myelin. Neuron 7(4):565-75. [PubMed: 1718333] [MGI Ref ID J:26987]
Pasparakis M; Kousteni S; Peschon J; Kollias G. 2000. Tumor necrosis factor and the p55TNF receptor are required for optimal development of the marginal sinus and for migration of follicular dendritic cell precursors into splenic follicles. Cell Immunol 201(1):33-41. [PubMed: 10805971] [MGI Ref ID J:62236]
Philippart C; Tzehoval E; Moricard Y; Bringuier AF; Seebold C; Lemoine FM; Arys A; Dourov N; Labat ML. 1993. Immune cell defects affect bone remodelling in osteopetrotic op/op mice. Bone Miner 23(3):317-32. [PubMed: 8148672] [MGI Ref ID J:18531]
Pollard JW; Dominguez MG; Mocci S; Cohen PE; Stanley ER. 1997. Effect of the colony-stimulating factor-1 null mutation, osteopetrotic (csfm(op)), on the distribution of macrophages in the male mouse reproductive tract. Biol Reprod 56(5):1290-300. [PubMed: 9160730] [MGI Ref ID J:40266]
Pollard JW; Hennighausen L. 1994. Colony stimulating factor 1 is required for mammary gland development during pregnancy. Proc Natl Acad Sci U S A 91(20):9312-6. [PubMed: 7937762] [MGI Ref ID J:20519]
Pollard JW; Hunt JS; Wiktor-Jedrzejczak W; Stanley ER. 1991. A pregnancy defect in the osteopetrotic (op/op) mouse demonstrates the requirement for CSF-1 in female fertility. Dev Biol 148(1):273-83. [PubMed: 1834496] [MGI Ref ID J:70400]
Pull SL; Doherty JM; Mills JC; Gordon JI; Stappenbeck TS. 2005. Activated macrophages are an adaptive element of the colonic epithelial progenitor niche necessary for regenerative responses to injury. Proc Natl Acad Sci U S A 102(1):99-104. [PubMed: 15615857] [MGI Ref ID J:95824]
Qian B; Deng Y; Im JH; Muschel RJ; Zou Y; Li J; Lang RA; Pollard JW. 2009. A distinct macrophage population mediates metastatic breast cancer cell extravasation, establishment and growth. PLoS One 4(8):e6562. [PubMed: 19668347] [MGI Ref ID J:152473]
Qiao JH; Tripathi J; Mishra NK; Cai Y; Tripathi S; Wang XP; Imes S ; Fishbein MC ; Clinton SK ; Libby P ; Lusis AJ ; Rajavashisth TB. 1997. Role of macrophage colony-stimulating factor in atherosclerosis: studies of osteopetrotic mice. Am J Pathol 150(5):1687-99. [PubMed: 9137093] [MGI Ref ID J:40136]
Qiu X; Zhu L; Pollard JW. 2009. Colony-stimulating factor-1-dependent macrophage functions regulate the maternal decidua immune responses against Listeria monocytogenes infections during early gestation in mice. Infect Immun 77(1):85-97. [PubMed: 18852237] [MGI Ref ID J:144590]
Raivich G; Moreno-Flores MT; Moller JC; Kreutzberg GW. 1994. Inhibition of posttraumatic microglial proliferation in a genetic model of macrophage colony-stimulating factor deficiency in the mouse. Eur J Neurosci 6(10):1615-8. [PubMed: 7850025] [MGI Ref ID J:128182]
Rajavashisth T; Qiao JH; Tripathi S; Tripathi J; Mishra N; Hua M ; Wang XP ; Loussararian A ; Clinton S ; Libby P ; Lusis A. 1998. Heterozygous osteopetrotic (op) mutation reduces atherosclerosis in LDL receptor- deficient mice. J Clin Invest 101(12):2702-10. [PubMed: 9637704] [MGI Ref ID J:48300]
Ryan GR; Dai XM; Dominguez MG; Tong W; Chuan F; Chisholm O; Russell RG; Pollard JW; Stanley ER. 2001. Rescue of the colony-stimulating factor 1 (CSF-1)-nullizygous mouse (Csf1(op)/Csf1(op)) phenotype with a CSF-1 transgene and identification of sites of local CSF-1 synthesis. Blood 98(1):74-84. [PubMed: 11418465] [MGI Ref ID J:70188]
Sasaki A; Yokoo H; Naito M; Kaizu C; Shultz LD; Nakazato Y. 2000. Effects of macrophage-colony-stimulating factor deficiency on the maturation of microglia and brain macrophages and on their expression of scavenger receptor. Neuropathology 20(2):134-42. [PubMed: 10935450] [MGI Ref ID J:82594]
Schonlau F; Schlesiger C; Ehrchen J; Grabbe S; Sorg C; Sunderkotter C. 2003. Monocyte and macrophage functions in M-CSF-deficient op/op mice during experimental leishmaniasis. J Leukoc Biol 73(5):564-73. [PubMed: 12714570] [MGI Ref ID J:120654]
Shibata Y; Zsengeller Z; Otake K; Palaniyar N; Trapnell BC. 2001. Alveolar macrophage deficiency in osteopetrotic mice deficient in macrophage colony-stimulating factor is spontaneously corrected with age and associated with matrix metalloproteinase expression and emphysema. Blood 98(9):2845-52. [PubMed: 11675359] [MGI Ref ID J:72385]
Smith JD; Trogan E; Ginsberg M; Grigaux C; Tian J; Miyata M. 1995. Decreased atherosclerosis in mice deficient in both macrophage colony-stimulating factor (op) and apolipoprotein E. Proc Natl Acad Sci U S A 92(18):8264-8. [PubMed: 7667279] [MGI Ref ID J:29024]
Stanley ER; Berg KL; Einstein DB; Lee PS; Pixley FJ; Wang Y; Yeung YG. 1997. Biology and action of colony--stimulating factor-1. Mol Reprod Dev 46(1):4-10. [PubMed: 8981357] [MGI Ref ID J:37433]
Stanley ER; Berg KL; Einstein DB; Lee PS; Yeung YG. 1994. The biology and action of colony stimulating factor-1. Stem Cells (Dayt) 12 Suppl 1:15-24. [PubMed: 7696959] [MGI Ref ID J:25733]
Suda T; Tanaka S; Takahashi N. 1993. Macrophage colon-stimulating factor (M-CSF) is essential for differentiation rather than proliferation of osteoclast progenitors. Osteoporos Int 3 Suppl 1:111-3. [PubMed: 8461535] [MGI Ref ID J:12210]
Sundquist KT; Cecchini MG; Marks SC. 1995. Colony-stimulating factor-1 injections improve but do not cure skeletal sclerosis in osteopetrotic (op) mice. Bone 16(1):39-46. [PubMed: 7742081] [MGI Ref ID J:26261]
Tagaya H; Kunisada T; Yamazaki H; Yamane T; Tokuhisa T; Wagner EF; Sudo T; Shultz LD; Hayashi SI. 2000. Intramedullary and extramedullary B lymphopoiesis in osteopetrotic mice. Blood 95(11):3363-70. [PubMed: 10828017] [MGI Ref ID J:82593]
Takahashi K; Naito M; Morioka Y; Schultz LD. 1993. Immunophenotypic and ultrastructural differentiation and maturation of nonlymphoid dendritic cells in osteopetrotic (op) mice with the total absence of macrophage colony stimulating factor activity. Adv Exp Med Biol 329:293-7. [PubMed: 8379385] [MGI Ref ID J:28547]
Takahashi K; Naito M; Shultz LD. 1992. Differentiation of epidermal Langerhans cells in macrophage colony-stimulating-factor-deficient mice homozygous for the osteopetrosis (op) mutation. J Invest Dermatol 99(5):46S-47S. [PubMed: 1431208] [MGI Ref ID J:3186]
Takahashi K; Naito M; Shultz LD; Hayashi S; Nishikawa S. 1993. Differentiation of dendritic cell populations in macrophage colony-stimulating factor-deficient mice homozygous for the osteopetrosis (op) mutation. J Leukoc Biol 53(1):19-28. [PubMed: 8426088] [MGI Ref ID J:4355]
Takahashi K; Naito M; Umeda S; Shultz LD. 1994. The role of macrophage colony-stimulating factor in hepatic glucan-induced granuloma formation in the osteopetrosis mutant mouse defective in the production of macrophage colony-stimulating factor. Am J Pathol 144(6):1381-92. [PubMed: 8203474] [MGI Ref ID J:18577]
Takahashi K; Umeda S; Shultz LD; Hayashi S; Nishikawa S. 1994. Effects of macrophage colony-stimulating factor (M-CSF) on the development, differentiation, and maturation of marginal metallophilic macrophages and marginal zone macrophages in the spleen of osteopetrosis (op) mutant mice lacking functional M-CSF activty. J Leukoc Biol 55(5):581-8. [PubMed: 8182336] [MGI Ref ID J:18058]
Takatsuka H; Umezu H; Hasegawa G; Usuda H; Ebe Y; Naito M; Shultz LD. 1998. Bone remodeling and macrophage differentiation in osteopetrosis (op) mutant mice defective in the production of macrophage colony-stimulating factor. J Submicrosc Cytol Pathol 30(2):239-47. [PubMed: 9648288] [MGI Ref ID J:113247]
Tavener SA; Kubes P. 2006. Cellular and molecular mechanisms underlying LPS-associated myocyte impairment. Am J Physiol Heart Circ Physiol 290(2):H800-6. [PubMed: 16172157] [MGI Ref ID J:106721]
Tiffee JC; Xing L; Nilsson S; Boyce BF. 1999. Dental abnormalities associated with failure of tooth eruption in src knockout and op/op mice. Calcif Tissue Int 65(1):53-8. [PubMed: 10369734] [MGI Ref ID J:56180]
Ueki Y; Lin CY; Senoo M; Ebihara T; Agata N; Onji M; Saheki Y; Kawai T; Mukherjee PM; Reichenberger E; Olsen BR. 2007. Increased myeloid cell responses to M-CSF and RANKL cause bone loss and inflammation in SH3BP2 'cherubism' mice. Cell 128(1):71-83. [PubMed: 17218256] [MGI Ref ID J:117880]
Umeda S; Beamer WG; Takagi K; Naito M; Hayashi S; Yonemitsu H; Yi T; Shultz LD. 1999. Deficiency of SHP-1 protein-tyrosine phosphatase activity results in heightened osteoclast function and decreased bone density. Am J Pathol 155(1):223-33. [PubMed: 10393854] [MGI Ref ID J:108187]
Umeda S; Takahashi K; Naito M; Shultz LD; Takagi K. 1996. Neonatal changes of osteoclasts in osteopetrosis (op/op) mice defective in production of functional macrophage colony-stimulating factor (M-CSF) protein and effects of M-CSF on osteoclast development and differentiation. J Submicrosc Cytol Pathol 28(1):13-26. [PubMed: 8929623] [MGI Ref ID J:33189]
Usuda H; Naito M; Umeda S; Takahashi K; Shultz LD. 1994. Ultrastructure of macrophages and dendritic cells in osteopetrosis (op) mutant mice lacking macrophage colony-stimulating factor (M-CSF/CSF-1) activity. J Submicrosc Cytol Pathol 26(1):111-9. [PubMed: 8149328] [MGI Ref ID J:18828]
Van Nguyen A; Pollard JW. 2002. Colony stimulating factor-1 is required to recruit macrophages into the mammary gland to facilitate mammary ductal outgrowth. Dev Biol 247(1):11-25. [PubMed: 12074549] [MGI Ref ID J:129047]
Voehringer D; van Rooijen N; Locksley RM. 2007. Eosinophils develop in distinct stages and are recruited to peripheral sites by alternatively activated macrophages. J Leukoc Biol 81(6):1434-44. [PubMed: 17339609] [MGI Ref ID J:122340]
Wegiel J; Wisniewski HM; Dziewiatkowski J; Tarnawski M; Kozielski R ; Trenkner E ; Wiktor-Jedrzejczak W. 1998. Reduced number and altered morphology of microglial cells in colony stimulating factor-1-deficient osteopetrotic op/op mice. Brain Res 804(1):135-9. [PubMed: 9729335] [MGI Ref ID J:49613]
Werner SA; Gluhak-Heinrich J; Woodruff K; Wittrant Y; Cardenas L; Roudier M; MacDougall M. 2007. Targeted expression of csCSF-1 in op/op mice ameliorates tooth defects. Arch Oral Biol 52(5):432-43. [PubMed: 17126805] [MGI Ref ID J:146705]
Wiktor-Jedrzejczak W; Ansari AA; Szperl M; Urbanowska E. 1992. Distinct in vivo functions of two macrophage subpopulations as evidenced by studies using macrophage-deficient op/op mouse. Eur J Immunol 22(7):1951-4. [PubMed: 1378025] [MGI Ref ID J:1517]
Wiktor-Jedrzejczak W; Bartocci A; Ferrante AW Jr; Ahmed-Ansari A; Sell KW; Pollard JW; Stanley ER. 1990. Total absence of colony-stimulating factor 1 in the macrophage-deficient osteopetrotic (op/op) mouse [published erratum appears in Proc Natl Acad Sci U S A 1991 Jul 1;88(13):5937] Proc Natl Acad Sci U S A 87(12):4828-32. [PubMed: 2191302] [MGI Ref ID J:33975]
Wiktor-Jedrzejczak W; Gordon S. 1996. Cytokine regulation of the macrophage (M phi) system studied using the colony stimulating factor-1-deficient op/op mouse. Physiol Rev 76(4):927-47. [PubMed: 8874489] [MGI Ref ID J:36652]
Wiktor-Jedrzejczak W; Ratajczak MZ; Ptasznik A; Sell KW; Ahmed-Ansari A; Ostertag W. 1992. CSF-1 deficiency in the op/op mouse has differential effects on macrophage populations and differentiation stages. Exp Hematol 20(8):1004-10. [PubMed: 1505635] [MGI Ref ID J:2131]
Wiktor-Jedrzejczak W; Urbanowska E; Szperl M. 1994. Granulocyte-macrophage colony-stimulating factor corrects macrophage deficiencies, but not osteopetrosis, in the colony-stimulating factor-1-deficient op/op mouse. Endocrinology 134(4):1932-5. [PubMed: 8137761] [MGI Ref ID J:17593]
Wiktor-Jedrzejczak WW; Ahmed A; Szczylik C; Skelly RR. 1982. Hematological characterization of congenital osteopetrosis in op/op mouse. Possible mechanism for abnormal macrophage differentiation J Exp Med 156(5):1516-27. [PubMed: 7130905] [MGI Ref ID J:104139]
Witmer-Pack MD; Hughes DA; Schuler G; Lawson L; McWilliam A; Inaba K; Steinman RM; Gordon S. 1993. Identification of macrophages and dendritic cells in the osteopetrotic (op/op) mouse. J Cell Sci 104(Pt 4):1021-9. [PubMed: 8314887] [MGI Ref ID J:4764]
Wood GW; Hausmann E; Choudhuri R. 1997. Relative role of CSF-1, MCP-1/JE, and RANTES in macrophage recruitment during successful pregnancy. Mol Reprod Dev 46(1):62-9; discussion 69-70. [PubMed: 8981365] [MGI Ref ID J:37428]
Wyckoff JB; Wang Y; Lin EY; Li JF; Goswami S; Stanley ER; Segall JE; Pollard JW; Condeelis J. 2007. Direct visualization of macrophage-assisted tumor cell intravasation in mammary tumors. Cancer Res 67(6):2649-56. [PubMed: 17363585] [MGI Ref ID J:120318]
Yamada G; Nakamura S; Haraguchi R; Sakai M; Suzuki K; Miyado K; Hasuwa H; Ogino Y; Minami T; Tohno Y; Blum M; Shultz LD. 1998. Aberrant regulation of bone trace elements in motheaten and osteopetrosis mutant mice. Cell Mol Biol (Noisy-le-grand) 44(2):315-9. [PubMed: 9593582] [MGI Ref ID J:47798]
Yamamoto N; Naraparaju VR. 1996. A defect in beta-galactosidase of B lymphocytes in the osteopetrotic (op/op) mouse. Immunol Lett 50(1-2):35-40. [PubMed: 8793557] [MGI Ref ID J:34280]
Yao GQ; Wu JJ; Ovadia S; Troiano N; Sun BH; Insogna K. 2009. Targeted overexpression of the two colony-stimulating factor-1 isoforms in osteoblasts differentially affects bone loss in ovariectomized mice. Am J Physiol Endocrinol Metab 296(4):E714-20. [PubMed: 19141689] [MGI Ref ID J:148134]
Yao GQ; Wu JJ; Sun BH; Troiano N; Mitnick MA; Insogna K. 2003. The cell surface form of colony-stimulating factor-1 is biologically active in bone in vivo. Endocrinology 144(8):3677-82. [PubMed: 12865350] [MGI Ref ID J:84815]
Yoshida H; Hayashi S; Kunisada T; Ogawa M; Nishikawa S; Okamura H; Sudo T; Shultz LD; Nishikawa S. 1990. The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor gene. Nature 345(6274):442-4. [PubMed: 2188141] [MGI Ref ID J:10519]
Zarebski A; Velu CS; Baktula AM; Bourdeau T; Horman SR; Basu S; Bertolone SJ; Horwitz M; Hildeman DA; Trent JO; Grimes HL. 2008. Mutations in growth factor independent-1 associated with human neutropenia block murine granulopoiesis through colony stimulating factor-1. Immunity 28(3):370-80. [PubMed: 18328744] [MGI Ref ID J:132941]
Zhang HH; Basu S; Wu F; Begley CG; Saris CJ; Dunn AR; Burgess AW; Walker F. 2007. Macrophage-colony stimulating factor is required for the production of neutrophil-promoting activity by mouse embryo fibroblasts deficient in G-CSF and GM-CSF. J Leukoc Biol 82(4):915-25. [PubMed: 17652450] [MGI Ref ID J:125155]
Zhou H; Lapointe BM; Clark SR; Zbytnuik L; Kubes P. 2006. A requirement for microglial TLR4 in leukocyte recruitment into brain in response to lipopolysaccharide. J Immunol 177(11):8103-10. [PubMed: 17114485] [MGI Ref ID J:140683]
de Villiers WJ; Smith JD; Miyata M; Dansky HM; Darley E; Gordon S. 1998. Macrophage phenotype in mice deficient in both macrophage-colony-stimulating factor (op) and apolipoprotein E. Arterioscler Thromb Vasc Biol 18(4):631-40. [PubMed: 9555870] [MGI Ref ID J:47535]
Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Room Number FGB29
Colony Maintenance
Breeding & Husbandry Homozygous pups (produced by a het x het mating) are identifiable by their phenotype at 10 days of age by absence of incisors and by a domed skull. Unfortunately, ~50% of homozygotes die around weaning age. If they are to survive the weaning process, they must be provided with crushed food in the bottom of the cage. A soft rodent diet could also be used. Those that survive weaning may live up to 6 months. Mating System Heterozygote x Heterozygote (Female x Male) 20-JUL-09 Diet Information LabDiet® 5K52/5K67
Purchasing information
Pricing, Supply Level & Notes, Controls, General Terms & Conditions
Pricing
| Pricing for USA, Canada and Mexico shipping destinations |
|
Weeks of Age Price (US dollars $) Gender Genotypes Provided Individual Mouse $122.20 Female or Male Heterozygous for Csf1op
Pairs /Price (US dollars $) Pair Genotype $244.40 Heterozygous for Csf1op x Heterozygous for Csf1op
Additional Supply Details
| Pricing for International shipping destinations |
|
Weeks of Age Price (US dollars $) Gender Genotypes Provided Individual Mouse $158.90 Female or Male Heterozygous for Csf1op
Pairs /Price (US dollars $) Pair Genotype $317.80 Heterozygous for Csf1op x Heterozygous for Csf1op
Additional Supply Details
|
|
|
Supply Details
| Standard Supply | Repository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of approximately nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within two business days following order placement. |
|---|---|
| Supply Notes |
|
Control Information
| Control | ||
|---|---|---|
| Untyped from the colony | ||
| Considerations for Choosing Controls | ||
| USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
| International - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
Payment Terms and Conditions
Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.
See Terms of Use tab for General Terms and Conditions
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
Purchasing Information
JAX® Mice Orders
Surgical Services
Contact Information
Orders & Technical Support
Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
Technical Support Email Form
Terms of Use
Terms of Use
General Terms and Conditions
Contact information
General inquiries
Contracts Administration
| phone: | 207-288-6470 |
| fax: | 207-288-6655 |
JAX® Mice, Products & Services Conditions of Use
"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.No Warranty
MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.
In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.
No Liability
In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. In purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.
MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.
The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.
Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.