Strain Name:

C3Wf.Cg-Hmga2pg/BmJ

Stock Number:

000233

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Availability:

Cryopreserved - Ready for recovery

Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Former Names C3H/HeNIcrWf-Hmgicpg/Bm    (Changed: 15-DEC-04 )
Type Congenic; Mutant Strain;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Additional information on Congenic nomenclature.
Specieslaboratory mouse
Background Strain C3H/HeNIcrWf
Donor Strain mixed stock

Appearance
agouti, small body size
Related Genotype: A/A Hmga2pg/Hmga2pg

agouti, unaffected
Related Genotype: A/A +/+ or Hmga2pg/+

Description
Mice homozygous for the pygmy mutation (Hmga2pg) are recognizably smaller at birth, growth rate is slow, and adults weigh about one-third as much as normal mice. They are healthy and active; some are sterile, but fertility may be almost normal on genetic backgrounds favoring large size. Pituitary, thyroid, and adrenals appear normal; Normal somatomedin activity; Normal serum levels of GH and PRL, but below normal concentrations in the pituitary; Unresponsive to administration of growth hormone.

Development
Pigmy (Hmga2pg) arose spontaneously in a stock of mice being selected for small size. In 1944 J.W. MacArthur described his experiment in which he interbred seven stocks and strains to generate a large F2 outbred stock, which was then subjected to selection based on body size. The seven stocks and strains were DBA and a silver chocolate stock from The Jackson Laboratory, black and tan (at) and pink-eyed/short-eared/dilute brown (p se d b a) from the University of Michigan, and MacArthur's own albino, cinnamon spotted, and agouti strains (J.W. MacArthur, 1944). Pygmy was imported to The Jackson Laboratory from Dr. George Wolf at the National Center for Toxocology Research, Jefferson AR. In 1979 the strain designation was C3H/HeNIcrWf-pg. It was maintained by using tested matings and was at generation N20F4 in 1980. It was cryopreserved in 1982, when that strain had reached generation N21F13, by mating tested males (pg/+) to untested (+/?) females.

Control Information

  Control
   Heterozygote from the colony
   Untyped from the colony
   Wild-type from the colony
 
  Considerations for Choosing Controls

Related Strains

Strains carrying other alleles of Hmga2
001962   B6 x STOCK In(10)17Rk/J
002644   B6.Cg-Hmga2pg-Tg40BCha/BmJ
View Strains carrying other alleles of Hmga2     (2 strains)

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested.
Leiomyoma, Uterine; UL   (HMGA2)
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

Hmga2pg/Hmga2pg

        involves: MacArthur's small stock
  • growth/size/body phenotype
  • decreased body size   (MGI Ref ID J:25351)
    • proportional dwarf   (MGI Ref ID J:25351)
      • no histological evidence of pituitary involvement   (MGI Ref ID J:13047)
      • proportionally small at 10 to 14 weeks   (MGI Ref ID J:10325)
    • slow postnatal weight gain
      • growth virtually ceases at 7-9 grams   (MGI Ref ID J:25351)
  • small ears   (MGI Ref ID J:10325)
  • homeostasis/metabolism phenotype
  • abnormal energy homeostasis
    • low vitality   (MGI Ref ID J:25351)
  • reproductive system phenotype
  • infertility   (MGI Ref ID J:25351)
    • fertility in both sexes is variable depending on genetic background   (MGI Ref ID J:13047)
  • craniofacial phenotype
  • small ears   (MGI Ref ID J:10325)
  • hearing/vestibular/ear phenotype
  • small ears   (MGI Ref ID J:10325)

Hmga2pg/Hmga2pg

        involves: A/St * C57BL * MacArthur's small stock
  • growth/size/body phenotype
  • abnormal postnatal growth/weight/body size   (MGI Ref ID J:13064)
    • decreased body size
      • markedly smaller than normal at birth   (MGI Ref ID J:13064)
      • decreased body weight
        • adults weigh about one-third as much as normal mice   (MGI Ref ID J:13064)
        • slow postnatal weight gain
          • negligible increase in weight from 12-21 days due to competition with normal siblings for milk   (MGI Ref ID J:13064)
    • postnatal growth retardation
      • the course of growth is normal but growth rate is reduced   (MGI Ref ID J:13064)
  • small ears
    • at 4 days of age the pinna of pygmy mice are smaller compared to normal mice   (MGI Ref ID J:13064)
    • by 12 days of age the ear size differential is pronounced   (MGI Ref ID J:13064)
  • craniofacial phenotype
  • small ears
    • at 4 days of age the pinna of pygmy mice are smaller compared to normal mice   (MGI Ref ID J:13064)
    • by 12 days of age the ear size differential is pronounced   (MGI Ref ID J:13064)
  • reproductive system phenotype
  • abnormal estrous cycle
    • females have an irregular estrous cycle   (MGI Ref ID J:13064)
  • cryptorchism
    • common among males   (MGI Ref ID J:13064)
  • female infertility   (MGI Ref ID J:13064)
  • male infertility   (MGI Ref ID J:13064)
  • priapism
    • develops in the majority of males by six weeks of age   (MGI Ref ID J:13064)
    • not correlated with testes descent   (MGI Ref ID J:13064)
  • small ovary
    • ovaries are small in proportion to body size   (MGI Ref ID J:13064)
    • follicle development is evident   (MGI Ref ID J:13064)
  • small testis   (MGI Ref ID J:13064)
  • small uterus
    • the uterus is small in proportion to body size   (MGI Ref ID J:13064)
  • endocrine/exocrine gland phenotype
  • cryptorchism
    • common among males   (MGI Ref ID J:13064)
  • small ovary
    • ovaries are small in proportion to body size   (MGI Ref ID J:13064)
    • follicle development is evident   (MGI Ref ID J:13064)
  • small testis   (MGI Ref ID J:13064)
  • limbs/digits/tail phenotype
  • brachypodia
    • feet are short relative to body length   (MGI Ref ID J:13064)
  • long tail
    • the tail is long in proportion to body length   (MGI Ref ID J:13064)
  • homeostasis/metabolism phenotype
  • abnormal energy homeostasis
    • lower than normal activity is not seen if normal siblings are removed from litters to increase milk available to mutant mice   (MGI Ref ID J:13064)
  • behavior/neurological phenotype
  • abnormal sexual interaction
    • sexual activity of males with normal genitalia does not extend beyond interest in oestral females   (MGI Ref ID J:13064)
  • hearing/vestibular/ear phenotype
  • small ears
    • at 4 days of age the pinna of pygmy mice are smaller compared to normal mice   (MGI Ref ID J:13064)
    • by 12 days of age the ear size differential is pronounced   (MGI Ref ID J:13064)
  • integument phenotype
  • long hair
    • the coat appears long in proportion to body length   (MGI Ref ID J:13064)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Hmga2pg related

Developmental Biology Research
Growth Defects

Endocrine Deficiency Research
Hypothalamus/Pituitary Defects

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Hmga2pg
Allele Name pygmy
Allele Type Spontaneous
Common Name(s) pg; pigmy;
Strain of OriginMacArthur's small stock
Gene Symbol and Name Hmga2, high mobility group AT-hook 2
Chromosome 10
Gene Common Name(s) 9430083A20Rik; HMGI-C; Hmgic; RIKEN cDNA 9430083A20 gene; high mobility group protein I, isoform C; pg; pygmy;
Molecular Note The mutant allele comprises a small deletion including 5' sequences and the first two exons of the Hmga2 gene. Northern blot analysis demonstrated that no detectable transcript is expressed from this allele. [MGI Ref ID J:28571] [MGI Ref ID J:74548]

Genotyping

Genotyping Information

Genotyping Protocols

Hmga2pg, QPCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Additional References

Hmga2pg related

Benson KF; Chada K. 2002. Molecular Characterization of the Mouse In(10)17Rk Inversion and Identification of a Novel Muscle-Specific Gene at the Proximal Breakpoint. Genetics 160(1):279-87. [PubMed: 11805063]  [MGI Ref ID J:74548]

Brants JR; Ayoubi TA; Chada K; Marchal K; Van de Ven WJ; Petit MM. 2004. Differential regulation of the insulin-like growth factor II mRNA-binding protein genes by architectural transcription factor HMGA2. FEBS Lett 569(1-3):277-83. [PubMed: 15225648]  [MGI Ref ID J:91358]

KING JW. 1950. Pygmy, a dwarfing gene in the house mouse. J Hered 41(9):249-52. [PubMed: 14794889]  [MGI Ref ID J:13064]

King JW. 1955. Observations on the mutant "pygmy" in the house mouse. J Genet 53:487-497.  [MGI Ref ID J:13047]

Macarthur JW. 1944. Genetics of body size and related characters Am Naturalist 78:142-57.  [MGI Ref ID J:25351]

Nissley SP; Knazek RA; Wolff GL. 1980. Somatomedin activity in sera of genetically small mice. Horm Metab Res 12(4):158-64. [PubMed: 7390396]  [MGI Ref ID J:6340]

Papaioannou G; Inloes JB; Nakamura Y; Paltrinieri E; Kobayashi T. 2013. let-7 and miR-140 microRNAs coordinately regulate skeletal development. Proc Natl Acad Sci U S A 110(35):E3291-300. [PubMed: 23940373]  [MGI Ref ID J:200909]

Rimoin DL; Richmond L. 1972. The pygmy (pg) mutant of the mouse--a model of the human pygmy. J Clin Endocrinol Metab 35(3):467-8. [PubMed: 5051369]  [MGI Ref ID J:5290]

Scala S; Portella G; Vitagliano D; Ledent C; Chiappetta G; Giancotti V; Dumont J; Fusco A. 2001. HMGI-C gene expression is not required for in vivo thyroid cell transformation. Carcinogenesis 22(2):251-6. [PubMed: 11181445]  [MGI Ref ID J:67486]

Sinha YN; Wolff GL; Baxter SR; Domon OE. 1979. Serum and pituitary concentrations of growth hormone and prolactin in pygmy mice. Proc Soc Exp Biol Med 162(1):221-3. [PubMed: 504232]  [MGI Ref ID J:6231]

Warwick EJ; Lewis WL. 1954. Increase in frequency of a deleterious recessive gene in mice J Hered 45:143-45.  [MGI Ref ID J:15334]

Xiang X; Benson KF; Chada K. 1990. Mini-mouse: disruption of the pygmy locus in a transgenic insertional mutant. Science 247(4945):967-9. [PubMed: 2305264]  [MGI Ref ID J:10325]

Zhou X; Benson KF; Ashar HR; Chada K. 1995. Mutation responsible for the mouse pygmy phenotype in the developmentally regulated factor HMGI-C [see comments] Nature 376(6543):771-4. [PubMed: 7651535]  [MGI Ref ID J:28571]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $2525.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $3283.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

General Supply Notes

  • View the complete collection of spontaneous mutants in the Mouse Mutant Resource.

Control Information

  Control
   Heterozygote from the colony
   Untyped from the colony
   Wild-type from the colony
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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