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- Description
- Phenotype
- Genes & alleles
- Genotyping
- Health & husbandry
- References
- Purchasing information
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Description
The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.
Strain Information
Former Names B6C3Fe-a/a-Rorasg/+ (Changed: 15-DEC-04 ) Type Mutant Strain; Spontaneous Mutation; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Species laboratory mouse Generation N44F1+N1p (01-AUG-04) Appearance
black, ataxic, tremors
Related Genotype: a/a Rorasg/Rorasg
black, unaffected
Related Genotype: a/a +/? or a/a Rorasg/+Description
Mice homozygous for the staggerer spontaneous mutation (Rorasg) show a staggering gait, mild tremor, hypotonia, and small size. The cerebellar cortex of homozygous mutant mice is grossly underdeveloped with a deficiency of granule cells and Purkinje cells. The remaining granule cells migrate inward from the external layer prematurely and then degenerate. Purkinje cells are much delayed in postnatal differentiation and lack the dendritic spines on which synapses with the parallel fibers from the granule cells normally occur. Staggerer mutant mice have been used as a source of an agranulate cerebellum in a number of investigations of the composition and function of granule cells. Kopmels et al. have reported a hyperproduction of IL1 biological activity and mRNA from LPS stimulated spleen cells of Rorasg/Rorasg mice on the C57BL/6J background relative to wild type siblings.
Control Information
| Control | ||
|---|---|---|
| Untyped from the colony | ||
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying Rorasg allele
002651 B6.C3(Cg)-Rorasg/J 000285 B6.Cg-Rorasg + +/+ Myo5ad Bmp5se/J View Strains carrying Rorasg (2 strains)
005047 C57BL/6J-Rorasg-3J/J
Phenotype
Phenotype Information
assigned by genotype
The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.
Rorasg/Rorasg
involves: obese stock
- lethality-postnatal
- postnatal lethality (MGI Ref ID J:13140)
- about 50% of mutants die by weaning
- nervous system phenotype
- abnormal brain morphology (MGI Ref ID J:13140)
- abnormal cerebellum morphology (MGI Ref ID J:13140)
- cerebellum of adults shows tiny folia with indistinct fissures
- cerebellum is less than one-third the size of wild-type littermates
- abnormal cerebellar foliation (MGI Ref ID J:13140)
- abnormal cerebellar granule layer (MGI Ref ID J:13140)
- granular cell layer displays a paucity of cells in mutants
- abnormal cerebellar molecular layer (MGI Ref ID J:13140)
- thin cerebellar molecular layer (MGI Ref ID J:13140)
- small cerebellum (MGI Ref ID J:13140)
- behavior/neurological phenotype
- abnormal motor capabilities/coordination/movement (MGI Ref ID J:13140)
- abnormal gait (MGI Ref ID J:13140)
- gait is shuffling and hesitant, interrupted every few steps by lurching motions side-to-side
- abnormal gait is apparent at ~2 weeks of age
- abnormal grip strength (MGI Ref ID J:46854)
- mice have a mean hanging time of 12 seconds compared to over 3 minutes for WT mice
- abnormal limb posture (MGI Ref ID J:13140)
- some animals have hindlimbs held abducted and everted at 45 degrees at rest
- ataxia (MGI Ref ID J:13140)
- clearly visible in all mice
- mice stumble at a rate 40 times greater than WT mice
- hypoactivity (MGI Ref ID J:13140)
- mutants remain stationary much more than littermates
- impaired coordination (MGI Ref ID J:13140)
- mice fall off an elevated rod on average of 13 seconds compared to over 3 minutes for WT mice
- limb grasping (MGI Ref ID J:46854)
- is observed in all mice
- tremors (MGI Ref ID J:13140)
- mild tremors accompany initiation of movement
- abnormal motor learning (MGI Ref ID J:46854)
- mice have an impaired ability to learn how to hang onto a rotating rod
- mice hang onto the rod as opposed the walking strategy WT mice exclusively use
- scores do not improve with 10 days of training
- growth/size phenotype
- decreased body size (MGI Ref ID J:13140)
- mutants are smaller than littermates
Rorasg/Rorasg
involves: C57BL/6
- homeostasis/metabolism phenotype
- abnormal lipid homeostasis (MGI Ref ID J:52105)
- plasma APOA1 and APOA2 concentrations are approximately 2 fold lower than in wild-type controls on a normal diet, and the Apoa1 mRNA level in intestine is diminished relative to wild-type, although liver expression of Apoa1 is comparable with wild-type
- the production rate of APOA1 is diminished, but the fractional catabolic rate is comparable to wild-type
- decreased circulating cholesterol level (MGI Ref ID J:52105)
- plasma total cholesterol levels are significantly lower in both male and female homozygotes than in wild-type controls
- although cholesterol levels increase on an atherosclerotic diet, homozygotes still have lower plasma cholesterol than wild-type controls also fed this diet
- decreased circulating HDL cholesterol level (MGI Ref ID J:52105)
- plasma HDL cholesterol level is significantly lower in both male and female homozygotes than in wild-type controls, and females have significantly lower plasma HDL level than males both for the homozygous and wild-type data sets. This is true even on an atherogenic diet.
- cardiovascular system phenotype
- atherosclerotic lesions (MGI Ref ID J:52105)
- the atherosclerotic lesions induced in homozygotes by 9 weeks of an atherosclerotic diet have a 6 fold greater area in female homozygotes and a 7.5 fold greater area in male homozygotes than those in wild-type controls on the same diet
- increased susceptibility to atherosclerosis (MGI Ref ID J:52105)
- Although homozygotes fed a normal diet do not display abnormal atherosclerotic lesions, 9 weeks of an atherosclerotic diet induces exaggerated altherosclerotic lesions compared with wild-type controls on the atherosclerotic diet
- immune system phenotype
- *normal* immune system phenotype (MGI Ref ID J:52105)
- white blood cell, lymphocyte, and neutrophil counts are not significantly different between homozygotes and wild-type controls
This mouse can be used to support research in many areas including:Rorasg related
Neurobiology Research
Ataxia (Movement) Defects
Cerebellar Defects
Purkinje cell defect
Receptor Defects
Tremor Defects
Genes & Alleles
Gene & Allele Information
| Allele Symbol | Rorasg | ||
|---|---|---|---|
| Allele Name | staggerer | ||
| Allele Type | Spontaneous | ||
| Common Name(s) | RORalpha-; sg; | ||
| Strain of Origin | obese stock | ||
| Gene Symbol and Name | Rora, RAR-related orphan receptor alpha | ||
| Chromosome | 9 | ||
| Gene Common Name(s) | 9530021D13Rik; DKFZp686M2414; MGC119326; MGC119329; NR1F1; RIKEN cDNA 9530021D13 gene; ROR1; ROR2; ROR3; RZR-ALPHA; RZRA; neuroscience mutagenesis facility, 267; nmf267; sg; staggerer; | ||
| General Note | Homozygotes for the staggerer mutation show a staggering gait, mild tremor, hypotonia, and small size (J:13140). The cerebellar cortex is grossly underdeveloped with a deficiency of granule cells and Purkinje cells. The deficiency of granule cells in theexternal granular layer is already evident at birth. The remaining granule cells migrate inward from the external layer prematurely and then degenerate (J:5304). Purkinje cells are much delayed in postnatal differentiation and lack the dendritic spines on which synapses with the parallel fibers from the granule cells normally occur (J:5968). Golgi cells are not clearly distinguishable from Purkinje cells and it is possible that their number is also reduced (J:6185). Examination of the cerebellum of chimeras of Rorasg/Rorasg with wild-type using cellular markers for Purkinje cells and granule cells has shown that the Rorasg effect is intrinsic to the Purkinje cells and that granule cells are affected secondarily (J:28093, J:11945). Purkinje cells are probably defective as early as postnatal day 4 (J:6875). The granule cell deficiency may result from failure of Purkinje cells to adequately stimulate granule cell genesis (J:28092), as well as from later cell death due to failure of synapsis with Purkinje cells. Staggerer mice have been used as a source of an agranulate cerebellum in a number of investigations of the composition and function of granule cells.Other effects of Rorasg include persistence of multipleinnervation of Purkinje cells by climbing fibers (J:6260), reduction in size of deep cerebellar nuclei (J:6554) and inferior olivary complex (J:7948), and abnormal patterns of ganglioside composition and enzymatic activity (J:7910). Inferior olivary neuron numbers and definition of the olivary subnuclei are normal at birth but decline thereafter (J:20982). Death of inferior olivary neurons, like that of granule cells, is apparently an indirect effect of the Rorasg gene, caused by the lack of Purkinje cells with which to synapse (J:28468).Cerebellar cells of Rorasg/Rorasg mice at 7 days postnatal have immature cell surface components of a type which are present in +/+ cells at late prenatal and neonatal stages (J:6068, J:6088). In particular, the conversion of neural cell adhesion molecules (NCAM) from embryonic to adult form which is normally complete by 21 days does not occur in Rorasg/Rorasg mice (J:6930).Purkinje cells are the predominant siteof expression of calmodulin in the cerebellum of normal mice, but Rorasg/Rorasg mice do not produce any mRNA for the Calm1 locus in these cells (J:28469).Peripheral macrophages of staggerer mice, and those of several other cerebellar mutant mice, show greatly increased production of interleukin 1 beta (J:28095). Since Il1a and Tnf are also hyperexpressed in staggerer macrophages, the increases represent a general condition of hyperexcitability of these cells (J:1431). Il6 hyperexpression was also found in Rorasg/Rorasg mice but not in Grid2/+ animals (J:11652), although the latter did show hyperexpression of Il1a, Il1b, and Tnf (J:2228). Matsui et al. (J:28478) report elevated levels of somatostatin in brainsof several ataxic mouse mutants, including Rorasg homozygotes. The concentration of thyrotropin releasing hormone (TH) is also elevated in brains of these mutants (J:28467), and administration of a TRH analog, YM-14673, ameliorated the ataxia,suggesting that excess TRH may have an ataxic effect (J:18435).The reproductive life of Rorasg/Rorasg female mice is curtailed by late sexual maturation, irregular estrous cycling, and a shortened post-puberal period of reproduction (J:1960). Neonatal vestibular stimulation by rotation on a tilted plain improved gait and body balance in Rorasg/Rorasg mice and also led to improved mating efficiency (J:14535), suggesting that mating defects in these mice may bea secondary effect of the gait and balance difficulties. Long-term selection for ability to reproduce improved the maternal behavior of homozygous staggerer females without abolishing gait and balance difficulties, suggesting that Rorasg effects on reproduction are not entirely due to these difficulties (J:28416).Male staggerer mice are able to differentiate between pheromones secreted by estrous and anestrous females (J:15645). Some male Rorasg/Rorasg mice suffer from a penile disability, the penis in erection being directed rearward. The disability is intermittent even in those males subject to it, and is of little importance in determining male mating deficiency (J:32193).Although Rorasg/+ heterozygotes are behaviorally normal with normal cerebellar cytoarchitecture and composition, these heterozygotes suffer accelerated loss of Purkinje cells, granule cells, and inferior olivary neurons with age (J:1431).Rorasg/Rorasg homozygotesusually die during the fourth week of life. Some survive to adulthood, and one male has bred (J:13140). | ||
| Molecular Note | This allele contains a 6.5kb genomic deletion of an exon encoding part of the ligand binding domain. The deletion results in an exon-skipping event that introduces a shift in the reading frame. The resulting protein is predicted to be truncated due to introduction of a premature stop codon. [MGI Ref ID J:31470] | ||
| Allele Symbol | a | ||
| Allele Name | nonagouti | ||
| Allele Type | Spontaneous | ||
Genotyping
Genotyping Information
Genotyping Protocols
Rorasg, Standard PCR
Helpful Links
Genotyping resources and troubleshooting
References
References
Selected Reference(s)
Mamontova A; Seguret-Mace S; Esposito B; Chaniale C; Bouly M; Delhaye-Bouchaud N; Luc G; Staels B; Duverger N; Mariani J; Tedgui A. 1998. Severe atherosclerosis and hypoalphalipoproteinemia in the staggerer mouse, a mutant of the nuclear receptor RORalpha. Circulation 98(24):2738-43. [PubMed: 9851961] [MGI Ref ID J:52105]
Additional References
Kopmels B; Wollman EE; Guastavino JM; Delhaye-Bouchaud N; Fradelizi D; Mariani J. 1990. Interleukin-1 hyperproduction by in vitro activated peripheral macrophages from cerebellar mutant mice. J Neurochem 55(6):1980-5. [PubMed: 2230805] [MGI Ref ID J:28095]
Yoon CH. 1972. Developmental mechanism for changes in cerebellum of staggerer mouse, a neurological mutant of genetic origin. Neurology 22(7):743-54. [PubMed: 4673255] [MGI Ref ID J:5304]
Rorasg relatedAngers M; Uldry M; Kong D; Gimble JM; Jetten AM. 2008. Mfsd2a encodes a novel major facilitator superfamily domain-containing protein highly induced in brown adipose tissue during fasting and adaptive thermogenesis. Biochem J 416(3):347-55. [PubMed: 18694395] [MGI Ref ID J:143949]
Bahjaoui-Bouhaddi M; Padilla F; Nicolet M; Cifuentes-Diaz C; Fellmann D; Mege RM. 1997. Localized deposition of M-cadherin in the glomeruli of the granular layer during the postnatal development of mouse cerebellum. (Erratum 1997;382:139) J Comp Neurol 378(2):180-95. [PubMed: 9120059] [MGI Ref ID J:38641]
Bakalian A; Kopmels B; Messer A; Fradelizi D; Delhaye-Bouchaud N; Wollman E; Mariani J. 1992. Peripheral macrophage abnormalities in mutant mice with spinocerebellar degeneration. Res Immunol 143(1):129-39. [PubMed: 1565842] [MGI Ref ID J:2228]
Baurle J; Hoshi M; Grusser-Cornehls U. 1998. Dependence of parvalbumin expression on Purkinje cell input in the deep cerebellar nuclei. J Comp Neurol 392(4):499-514. [PubMed: 9514513] [MGI Ref ID J:118391]
Bensoula AN; Guastavino JM; Lalonde R; Portet R; Bertin R; Krafft B. 1995. Spatial navigation of staggerer and normal mice during juvenile and adult stages. Physiol Behav 58(5):823-5. [PubMed: 8577876] [MGI Ref ID J:30012]
Berrebi AS; Morgan JI; Mugnaini E. 1990. The Purkinje cell class may extend beyond the cerebellum. J Neurocytol 19(5):643-54. [PubMed: 2077109] [MGI Ref ID J:121314]
Besnard S; Bakouche J; Lemaigre-Dubreuil Y; Mariani J; Tedgui A; Henrion D. 2002. Smooth muscle dysfunction in resistance arteries of the staggerer mouse, a mutant of the nuclear receptor RORalpha. Circ Res 90(7):820-5. [PubMed: 11964376] [MGI Ref ID J:109735]
Besnard S; Silvestre JS; Duriez M; Bakouche J; Lemaigre-Dubreuil Y; Mariani J; Levy BI; Tedgui A. 2001. Increased ischemia-induced angiogenesis in the staggerer mouse, a mutant of the nuclear receptor Roralpha. Circ Res 89(12):1209-15. [PubMed: 11739287] [MGI Ref ID J:115425]
Blatt GJ; Eisenman LM. 1985. A qualitative and quantitative light microscopic study of the inferior olivary complex in the adult staggerer mutant mouse. J Neurogenet 2(1):51-66. [PubMed: 4020530] [MGI Ref ID J:7948]
Boufares S; Guastavino JM; Larsson K. 1993. Restoration of staggerer mouse maternal behavior following long-term breeding selection. Physiol Behav 53(6):1151-5. [PubMed: 8346298] [MGI Ref ID J:14497]
Brugg B; Dubreuil YL; Huber G; Wollman EE; Delhaye-Bouchaud N; Mariani J. 1995. Inflammatory processes induce beta-amyloid precursor protein changes in mouse brain. Proc Natl Acad Sci U S A 92(7):3032. [PubMed: 7708769] [MGI Ref ID J:24161]
Caston J; Chianale C; Mariani J. 2004. Spatial memory of heterozygous staggerer (Rora(+)/Rora(sg)) versus normal (Rora(+)/Rora(+)) mice during aging. Behav Genet 34(3):319-24. [PubMed: 14990870] [MGI Ref ID J:101986]
Caston J; Delhaye-Bouchaud N; Mariani J. 1995. Motor behavior of heterozygous staggerer mutant (+/sg) versus normal (+/+) mice during aging. Behav Brain Res 72(1-2):97-102. [PubMed: 8788862] [MGI Ref ID J:31409]
Caston J; Hilber P; Chianale C; Mariani J. 2003. Effect of training on motor abilities of heterozygous staggerer mutant (Rora(+)/Rora(sg)) mice during aging. Behav Brain Res 141(1):35-42. [PubMed: 12672557] [MGI Ref ID J:96224]
Chung Y; Chang SH; Martinez GJ; Yang XO; Nurieva R; Kang HS; Ma L; Watowich SS; Jetten AM; Tian Q; Dong C. 2009. Critical regulation of early Th17 cell differentiation by interleukin-1 signaling. Immunity 30(4):576-87. [PubMed: 19362022] [MGI Ref ID J:147961]
Costanzo RV; Vila-Ortiz GJ; Perandones C; Carminatti H; Matilla A; Radrizzani M. 2006. Anp32e/Cpd1 regulates protein phosphatase 2A activity at synapses during synaptogenesis. Eur J Neurosci 23(2):309-24. [PubMed: 16420440] [MGI Ref ID J:105399]
Crepel F; Delhaye-Bouchaud N; Guastavino JM; Sampaio I. 1980. Multiple innervation of cerebellar Purkinje cells by climbing fibres in staggerer mutant mouse. Nature 283(5746):483-4. [PubMed: 7352029] [MGI Ref ID J:6260]
Deiss V; Baudoin C. 1997. Hyposmia for butanol and vanillin in mutant staggerer male mice. Physiol Behav 61(2):209-13. [PubMed: 9035249] [MGI Ref ID J:39053]
Deiss V; Baudoin C. 1999. Olfactory learning abilities in staggerer mutant mice. C R Acad Sci III 322(6):467-71. [PubMed: 10457598] [MGI Ref ID J:58061]
Deiss V; Dubois M; Lalonde R; Strazielle C. 2001. Cytochrome oxidase activity in the olfactory system of staggerer mutant mice. Brain Res 910(1-2):126-33. [PubMed: 11489262] [MGI Ref ID J:71124]
Deiss V; Feron C; Baudoin C. 1999. Discrimination of olfactory sexual cues in staggerer mutant male mice. Physiol Behav 67(5):631-4. [PubMed: 10604831] [MGI Ref ID J:96570]
Deiss V; Strazielle C; Lalonde R. 2000. Regional brain variations of cytochrome oxidase activity and motor co-ordination in staggerer mutant mice. Neuroscience 95(3):903-11. [PubMed: 10670457] [MGI Ref ID J:111971]
Doulazmi M; Frederic F; Capone F; Becker-Andre M; Delhaye-Bouchaud N; Mariani J. 2001. A comparative study of Purkinje cells in two RORalpha gene mutant mice: staggerer and RORalpha(-/-). Brain Res Dev Brain Res 127(2):165-74. [PubMed: 11335003] [MGI Ref ID J:69287]
Doulazmi M; Frederic F; Lemaigre-Dubreuil Y; Hadj-Sahraoui N ; Delhaye-Bouchaud N ; Mariani J. 1999. Cerebellar Purkinje cell loss during life span of the heterozygous staggerer mouse (Rora(+)/Rora(sg)) is gender-related. J Comp Neurol 411(2):267-73. [PubMed: 10404252] [MGI Ref ID J:56379]
Duez H; Duhem C; Laitinen S; Patole PS; Abdelkarim M; Bois-Joyeux B; Danan JL; Staels B. 2009. Inhibition of adipocyte differentiation by RORalpha. FEBS Lett 583(12):2031-6. [PubMed: 19450581] [MGI Ref ID J:150001]
Edelman GM; Chuong CM. 1982. Embryonic to adult conversion of neural cell adhesion molecules in normal and staggerer mice. Proc Natl Acad Sci U S A 79(22):7036-40. [PubMed: 6960362] [MGI Ref ID J:6930]
Feron C; Baudoin C. 1992. Reactions of Staggerer and Non-Mutant Male Mice to Female Urine and Vaginal Secretion Odors Behav Processes 27(3):165-70. [MGI Ref ID J:3557]
Feron C; Baudoin C. 1993. Sexual experience and preferences for odors of estrous females in staggerer mutant male mice. Behav Neural Biol 60(3):280-1. [PubMed: 8297325] [MGI Ref ID J:15645]
Feron C; Baudoin C. 1998. Social isolation induces preference for odours of oestrous females in sexually naive male staggerer mutant mice. Chem Senses 23(1):119-21. [PubMed: 9530977] [MGI Ref ID J:46472]
Feron C; Baudoin C. 1995. Social isolation partially restores reproduction of male staggerer mutant mice. Physiol Behav 58(1):107-10. [PubMed: 7667406] [MGI Ref ID J:26698]
Feron C; Baudoin C. 1992. [Reduced influence of penile disability on the mating capacity of male staggerer mice] Reprod Nutr Dev 32(5-6):409-13. [PubMed: 1292478] [MGI Ref ID J:32193]
Frantz GD; Wuenschell CW; Messer A; Tobin AJ. 1996. Presence of calbindin D28K and GAD67 mRNAs in both orthotopic and ectopic Purkinje cells of staggerer mice suggests that staggerer acts after the onset of cytodifferentiation. J Neurosci Res 44(3):255-62. [PubMed: 8723764] [MGI Ref ID J:32917]
Genoux A; Dehondt H; Helleboid-Chapman A; Duhem C; Hum DW; Martin G; Pennacchio LA; Staels B; Fruchart-Najib J; Fruchart JC. 2005. Transcriptional regulation of apolipoprotein A5 gene expression by the nuclear receptor RORalpha. Arterioscler Thromb Vasc Biol 25(6):1186-92. [PubMed: 15790933] [MGI Ref ID J:114292]
Giguere V; Beatty B; Squire J; Copeland NG; Jenkins NA. 1995. The orphan nuclear receptor ROR alpha (RORA) maps to a conserved region of homology on human chromosome 15q21-q22 and mouse chromosome 9. Genomics 28(3):596-8. [PubMed: 7490103] [MGI Ref ID J:28416]
Gold DA; Baek SH; Schork NJ; Rose DW; Larsen DD; Sachs BD; Rosenfeld MG; Hamilton BA. 2003. RORalpha coordinates reciprocal signaling in cerebellar development through sonic hedgehog and calcium-dependent pathways. Neuron 40(6):1119-31. [PubMed: 14687547] [MGI Ref ID J:87181]
Gold DA; Gent PM; Hamilton BA. 2007. ROR alpha in genetic control of cerebellum development: 50 staggering years. Brain Res 1140:19-25. [PubMed: 16427031] [MGI Ref ID J:120622]
Grunwald GB; Eisenman LM. 1993. Analysis of protein variations in adult and postnatal day 11 staggerer and lurcher mutant mice. Brain Res Dev Brain Res 73(1):146-50. [PubMed: 8513552] [MGI Ref ID J:11841]
Guastavino JM; Larsson K. 1992. The staggerer gene curtails the reproductive life span of females. Behav Genet 22(1):101-12. [PubMed: 1590727] [MGI Ref ID J:1960]
Guastavino JM; Larsson K; Allain C; Jaisson P. 1993. Neonatal vestibular stimulation and mating in cerebellar mutants. Behav Genet 23(3):265-9. [PubMed: 8352721] [MGI Ref ID J:14535]
Guo H; Sekiguchi M; Tanaka O; Inoue T; Shima H; Nagao M; Tamura S; Abe H. 1995. Protein phosphatase mRNA expression in Purkinje cells of staggerer and reeler mutant mice. Brain Res Mol Brain Res 33(1):121-6. [PubMed: 8774953] [MGI Ref ID J:28842]
Hadj-Sahraoui N; Frederic F; Zanjani H; Delhaye-Bouchaud N; Herrup K; Mariani J. 2001. Progressive atrophy of cerebellar Purkinje cell dendrites during aging of the heterozygous staggerer mouse (Rora(+/sg)). Brain Res Dev Brain Res 126(2):201-9. [PubMed: 11248354] [MGI Ref ID J:68149]
Hadj-Sahraoui N; Frederic F; Zanjani H; Herrup K; Delhaye-Bouchaud N ; Mariani J. 1997. Purkinje cell loss in heterozygous staggerer mutant mice during aging. Brain Res Dev Brain Res 98(1):1-8. [PubMed: 9027398] [MGI Ref ID J:37701]
Hamilton BA; Frankel WN; Kerrebrock AW; Hawkins TL; FitzHugh W; Kusumi K; Russell LB; Mueller KL; van Berkel V; Birren BW; Kruglyak L; Lander ES. 1996. Disruption of the nuclear hormone receptor RORalpha in staggerer mice. Nature 379(6567):736-9. [PubMed: 8602221] [MGI Ref ID J:31470]
Hatten ME; Messer A. 1978. Postnatal cerebellar cells from staggerer mutant mice express embryonic cell surface characteristic. Nature 276(5687):504-6. [PubMed: 723931] [MGI Ref ID J:6068]
Herrup K. 1983. Role of staggerer gene in determining cell number in cerebellar cortex. I. Granule cell death is an indirect consequence of staggerer gene action. Brain Res 313(2):267-74. [PubMed: 6667376] [MGI Ref ID J:28093]
Herrup K; Mullen RJ. 1979. Regional variation and absence of large neurons in the cerebellum of the staggerer mouse. Brain Res 172(1):1-12. [PubMed: 466453] [MGI Ref ID J:6185]
Herrup K; Mullen RJ. 1979. Staggerer chimeras: intrinsic nature of Purkinje cell defects and implications for normal cerebellar development. Brain Res 178(2-3):443-57. [PubMed: 509213] [MGI Ref ID J:11945]
Heuze P; Feron C; Baudoin C. 1997. Early behavioral development of mice is affected by staggerer mutation as soon as postnatal day three. Brain Res Dev Brain Res 101(1-2):81-4. [PubMed: 9263582] [MGI Ref ID J:42144]
Ikeda M; Matsui K; Ishihara Y; Morita I; Murota S; Yuasa T; Miyatake T. 1994. Cerebellar nitric oxide synthase, cGMP and motor function in two lines of cerebellar mutant mice, Staggerer and Wriggle Mouse Sagami. Neurosci Lett 168(1-2):65-8. [PubMed: 7518067] [MGI Ref ID J:18352]
Jaradat M; Stapleton C; Tilley SL; Dixon D; Erikson CJ; McCaskill JG; Kang HS; Angers M; Liao G; Collins J; Grissom S; Jetten AM. 2006. Modulatory role for retinoid-related orphan receptor alpha in allergen-induced lung inflammation. Am J Respir Crit Care Med 174(12):1299-309. [PubMed: 16973978] [MGI Ref ID J:135863]
Jarvis CI; Staels B; Brugg B; Lemaigre-Dubreuil Y; Tedgui A; Mariani J. 2002. Age-related phenotypes in the staggerer mouse expand the RORalpha nuclear receptor's role beyond the cerebellum. Mol Cell Endocrinol 186(1):1-5. [PubMed: 11850116] [MGI Ref ID J:75570]
Ji Z; Jin Q; Vogel MW. 1997. Evidence of spinocerebellar mossy fiber segregation in the juvenile staggerer cerebellum. J Comp Neurol 378(3):354-62. [PubMed: 9034896] [MGI Ref ID J:38768]
Jin P; Sun Y; Grabowski GA. 2001. In vivo roles of RORalpha and Sp4 in the regulation of murine prosaposin gene. DNA Cell Biol 20(12):781-9. [PubMed: 11879571] [MGI Ref ID J:74710]
Jorgensen OS. 1994. Neural cell adhesion molecule and D3 protein in the cerebellum of weaver mutant mice. Int J Dev Neurosci 12(3):213-25. [PubMed: 7942094] [MGI Ref ID J:19350]
Kopmels B; Mariani J; Delhaye-Bouchaud N; Audibert F; Fradelizi D; Wollman EE. 1992. Evidence for a hyperexcitability state of staggerer mutant mice macrophages. J Neurochem 58(1):192-9. [PubMed: 1727430] [MGI Ref ID J:28096]
Kopmels B; Mariani J; Taupin V; Delhaye-Bouchaud N; Wollman EE. 1991. Differential IL-6 mRNA expression by stimulated peripheral macrophages of Staggerer and Lurcher cerebellar mutant mice. Eur Cytokine Netw 2(5):345-53. [PubMed: 1804324] [MGI Ref ID J:11652]
Kopmels B; Wollman EE; Guastavino JM; Delhaye-Bouchaud N; Fradelizi D; Mariani J. 1990. Interleukin-1 hyperproduction by in vitro activated peripheral macrophages from cerebellar mutant mice. J Neurochem 55(6):1980-5. [PubMed: 2230805] [MGI Ref ID J:28095]
Lalonde R; Bensoula AN; Filali M. 1995. Rotorod sensorimotor learning in cerebellar mutant mice. Neurosci Res 22(4):423-6. [PubMed: 7478307] [MGI Ref ID J:28880]
Lalonde R; Filali M; Bensoula AN; Lestienne F. 1996. Sensorimotor learning in three cerebellar mutant mice. Neurobiol Learn Mem 65(2):113-20. [PubMed: 8833100] [MGI Ref ID J:31867]
Lalonde R; Filali M; Bensoula AN; Monnier C; Guastavino JM. 1996. Spatial learning in a Z-maze by cerebellar mutant mice. Physiol Behav 59(1):83-6. [PubMed: 8848495] [MGI Ref ID J:30686]
Lalonde R; Strazielle C. 2007. Spontaneous and induced mouse mutations with cerebellar dysfunctions: behavior and neurochemistry. Brain Res 1140:51-74. [PubMed: 16499884] [MGI Ref ID J:120621]
Landis DM; Sidman RL. 1978. Electron microscopic analysis of postnatal histogenesis in the cerebellar cortex of staggerer mutant mice. J Comp Neurol 179(4):831-63. [PubMed: 641237] [MGI Ref ID J:5968]
Lau P; Fitzsimmons RL; Raichur S; Wang SC; Lechtken A; Muscat GE. 2008. The orphan nuclear receptor, RORalpha, regulates gene expression that controls lipid metabolism: staggerer (SG/SG) mice are resistant to diet-induced obesity. J Biol Chem 283(26):18411-21. [PubMed: 18441015] [MGI Ref ID J:138180]
Lemaigre-Dubreuil Y; Brugg B; Chianale C; Delhaye-Bouchaud N; Mariani J. 1996. Over-expression of interleukin-1 beta-converting enzyme mRNA in staggerer cerebellum. Neuroreport 7(11):1777-80. [PubMed: 8905663] [MGI Ref ID J:36680]
Luntz-Leybman V; Rotter A; Zdilar D; Frostholm A. 1995. Uncoupling of GABAA/benzodiazepine receptor alpha 1, beta 2, and gamma 2 subunit mRNA expression in cerebellar Purkinje cells of staggerer mutant mice. J Neurosci 15(12):8121-30. [PubMed: 8613747] [MGI Ref ID J:30353]
Mallet J; Huchet M; Pougeois R; Changeux JP. 1976. Anatomical, physiological and biochemical studies on the cerebellum from mutant mice. III. Protein differences associated with the weaver, staggerer and nervous mutations. Brain Res 103(2):291-312. [PubMed: 1252920] [MGI Ref ID J:5619]
Matsui K; Itoh K; Mizumachi M; Kubo H; Goto T; Sato S; Wada K. 1996. Effect of intranasal administration of thyrotropin-releasing hormone on ataxic gait in staggerer mice. Neurosci Lett 212(2):115-8. [PubMed: 8832652] [MGI Ref ID J:35010]
Matsui K; Kato N; Watanabe N; Ando K. 1988. [Elevated immunoreactive-somatostatin levels in the brain of ataxic mutant mice] Jikken Dobutsu 37(3):263-8. [PubMed: 2901364] [MGI Ref ID J:28478]
Matsui K; Wada K; Kwak S. 1994. Ataxia-ameliorating effects of YM-14673, a potent analog of thyrotropin releasing hormone, in ataxic mutant mice. Eur J Pharmacol 254(3):295-7. [PubMed: 8013566] [MGI Ref ID J:18435]
Matysiak-Scholze U; Nehls M. 1997. The structural integrity of ROR alpha isoforms is mutated in staggerer mice: cerebellar coexpression of ROR alpha1 and ROR alpha4. Genomics 43(1):78-84. [PubMed: 9226375] [MGI Ref ID J:41653]
Messer A; Plummer-Siegard J; Eisenberg B. 1990. Staggerer mutant mouse Purkinje cells do not contain detectable calmodulin mRNA. J Neurochem 55(1):293-302. [PubMed: 2355223] [MGI Ref ID J:28469]
Michel V; Monnier Z; Guastavino JM; Propper A; Math F. 2000. Functional alterations in the olfactory bulb of the staggerer mutant mouse. Neurosci Lett 280(1):1-4. [PubMed: 10696797] [MGI Ref ID J:107925]
Miret-Duvaux O; Frederic F; Simon D; Guenet JL; Hanauer A; Delhaye-Bouchaud N; Mariani J. 1990. Glutamate dehydrogenase in cerebellar mutant mice: gene localization and enzyme activity in different tissues. J Neurochem 54(1):23-9. [PubMed: 2293612] [MGI Ref ID J:10148]
Mitsuma T; Adachi K; Mukoyama M; Ando K. 1990. Pro-thyrotropin-releasing hormone concentrations in the brain of ataxic mice. J Neurol Sci 98(2-3):163-7. [PubMed: 2123001] [MGI Ref ID J:28467]
Monnier Z; Bahjaoui-Bouhaddi M; Bride J; Bride M; Math F; Propper A. 1999. Structural and immunohistological modifications in olfactory bulb of the staggerer mutant mouse. Biol Cell 91(1):29-44. [PubMed: 10321020] [MGI Ref ID J:55239]
Murase S; Hayashi Y. 1998. Expression pattern and neurotrophic role of the c-fms proto-oncogene M-CSF receptor in rodent Purkinje cells. J Neurosci 18(24):10481-92. [PubMed: 9852586] [MGI Ref ID J:52174]
Murase S; Hayashi Y. 1996. Expression pattern of integrin beta 1 subunit in Purkinje cells of rat and cerebellar mutant mice. J Comp Neurol 375(2):225-37. [PubMed: 8915827] [MGI Ref ID J:36459]
Nakagawa S; Watanabe M; Inoue Y. 1996. Altered gene expression of the N-methyl-D-aspartate receptor channel subunits in Purkinje cells of the staggerer mutant mouse. Eur J Neurosci 8(12):2644-51. [PubMed: 8996814] [MGI Ref ID J:39065]
Nakagawa S; Watanabe M; Inoue Y. 1996. Regional variation in expression of calbindin and inositol 1,4,5-trisphosphate receptor type 1 mRNAs in the cerebellum of the staggerer mutant mouse. Eur J Neurosci 8(7):1401-7. [PubMed: 8758947] [MGI Ref ID J:35712]
Nakagawa S; Watanabe M; Isobe T; Kondo H; Inoue Y. 1998. Cytological compartmentalization in the staggerer cerebellum, as revealed by calbindin immunohistochemistry for Purkinje cells. J Comp Neurol 395(1):112-20. [PubMed: 9590549] [MGI Ref ID J:47380]
Nurieva RI; Chung Y; Hwang D; Yang XO; Kang HS; Ma L; Wang YH; Watowich SS; Jetten AM; Tian Q; Dong C. 2008. Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages. Immunity 29(1):138-49. [PubMed: 18599325] [MGI Ref ID J:137869]
Perandones C; Costanzo RV; Kowaljow V; Pivetta OH; Carminatti H; Radrizzani M. 2004. Correlation between synaptogenesis and the PTEN phosphatase expression in dendrites during postnatal brain development. Brain Res Mol Brain Res 128(1):8-19. [PubMed: 15337313] [MGI Ref ID J:92848]
Qiu CH; Shimokawa N; Iwasaki T; Parhar IS; Koibuchi N. 2007. Alteration of cerebellar neurotropin messenger ribonucleic acids and the lack of thyroid hormone receptor augmentation by staggerer-type retinoic acid receptor-related orphan receptor-alpha mutation. Endocrinology 148(4):1745-53. [PubMed: 17218417] [MGI Ref ID J:129580]
Radrizzani M; Carminatti H; Pivetta OH; Idoyaga Vargas VP. 1995. Developmental regulation of Thy 1.2 rate of synthesis in the mouse cerebellum. J Neurosci Res 42(2):220-7. [PubMed: 8568922] [MGI Ref ID J:29491]
Raspe E; Duez H; Gervois P; Fievet C; Fruchart JC; Besnard S; Mariani J; Tedgui A; Staels B. 2001. Transcriptional regulation of apolipoprotein C-III gene expression by the orphan nuclear receptor RORalpha. J Biol Chem 276(4):2865-71. [PubMed: 11053433] [MGI Ref ID J:124837]
Roffler-Tarlov S; Herrup K. 1981. Quantitative examination of the deep cerebellar nuclei in the staggerer mutant mouse. Brain Res 215(1-2):49-59. [PubMed: 7260600] [MGI Ref ID J:6554]
Roffler-Tarlov S; Turey M. 1982. The content of amino acids in the developing cerebellar cortex and deep cerebellar nuclei of granule cell deficient mutant mice. Brain Res 247(1):65-73. [PubMed: 6127146] [MGI Ref ID J:6875]
Ryo Y; Miyawaki A; Furuichi T; Mikoshiba K. 1993. Expression of the metabotropic glutamate receptor mGluR1 alpha and the ionotropic glutamate receptor GluR1 in the brain during the postnatal development of normal mouse and in the cerebellum from mutant mice. J Neurosci Res 36(1):19-32. [PubMed: 8230318] [MGI Ref ID J:14425]
SIDMAN RL; LANE PW; DICKIE MM. 1962. Staggerer, a new mutation in the mouse affecting the cerebellum. Science 137:610-2. [PubMed: 13912552] [MGI Ref ID J:13140]
Schaal H; Wille C; Wille W. 1985. Changes of ganglioside pattern during cerebellar development of normal and staggerer mice. J Neurochem 45(2):544-51. [PubMed: 4009175] [MGI Ref ID J:7910]
Serinagaoglu Y; Zhang R; Zhang Y; Zhang L; Hartt G; Young AP; Oberdick J. 2007. A promoter element with enhancer properties, and the orphan nuclear receptor RORalpha, are required for Purkinje cell-specific expression of a Gi/o modulator. Mol Cell Neurosci 34(3):324-42. [PubMed: 17215137] [MGI Ref ID J:123239]
Shirley LT; Messer A. 2004. Early postnatal Purkinje cells from staggerer mice undergo aberrant development in vitro with characteristic morphologic and gene expression abnormalities. Brain Res Dev Brain Res 152(2):153-7. [PubMed: 15351503] [MGI Ref ID J:109172]
Soha JM; Herrup K. 1993. Purkinje cell dendrites in staggerer<-->wild type mouse chimeras lack the aberrant morphologies found in lurcher<-->wild type chimeras. J Comp Neurol 331(4):540-50. [PubMed: 8509510] [MGI Ref ID J:12149]
Soha JM; Herrup K. 1995. Stunted morphologies of cerebellar Purkinje cells in lurcher and staggerer mice are cell-intrinsic effects of the mutant genes. J Comp Neurol 357(1):65-75. [PubMed: 7673468] [MGI Ref ID J:26094]
Soha JM; Kim S; Crandall JE; Vogel MW. 1997. Rapid growth of parallel fibers in the cerebella of normal and staggerer mutant mice. J Comp Neurol 389(4):642-54. [PubMed: 9421144] [MGI Ref ID J:44432]
Sonmez E; Herrup K. 1984. Role of staggerer gene in determining cell number in cerebellar cortex. II. Granule cell death and persistence of the external granule cell layer in young mouse chimeras. Brain Res 314(2):271-83. [PubMed: 6704753] [MGI Ref ID J:28092]
Sotelo C. 1990. Cerebellar synaptogenesis: what we can learn from mutant mice. J Exp Biol 153:225-49. [PubMed: 2280222] [MGI Ref ID J:10974]
Stapleton CM; Jaradat M; Dixon D; Kang HS; Kim SC; Liao G; Carey MA; Cristiano J; Moorman MP; Jetten AM. 2005. Enhanced susceptibility of staggerer (RORalphasg/sg) mice to lipopolysaccharide-induced lung inflammation. Am J Physiol Lung Cell Mol Physiol 289(1):L144-52. [PubMed: 15778248] [MGI Ref ID J:104750]
Steinmayr M; Andre E; Conquet F; Rondi-Reig L; Delhaye-Bouchaud N ; Auclair N ; Daniel H ; Crepel F ; Mariani J ; Sotelo C ; Becker-Andre M. 1998. staggerer phenotype in retinoid-related orphan receptor alpha-deficient mice. Proc Natl Acad Sci U S A 95(7):3960-5. [PubMed: 9520475] [MGI Ref ID J:46854]
Trenkner E. 1979. Postnatal cerebellar cells of staggerer mutant mice express immature components on their surface. Nature 277(5697):566-7. [PubMed: 368650] [MGI Ref ID J:6088]
Triarhou LC; Low WC; Ghetti B. 1987. Transplantation of cerebellar anlagen to hosts with genetic cerebellocortical atrophy. Anat Embryol (Berl) 176(2):145-54. [PubMed: 3619071] [MGI Ref ID J:28471]
Varecka L; Wu CH; Rotter A; Frostholm A. 1994. GABAA/benzodiazepine receptor alpha 6 subunit mRNA in granule cells of the cerebellar cortex and cochlear nuclei: expression in developing and mutant mice. J Comp Neurol 339(3):341-52. [PubMed: 8132866] [MGI Ref ID J:16213]
Vernet-der Garabedian B; Lemaigre-Dubreuil Y; Delhaye-Bouchaud N ; Mariani J. 1998. Abnormal IL-1beta cytokine expression in the cerebellum of the ataxic mutant mice staggerer and lurcher. Brain Res Mol Brain Res 62(2):224-7. [PubMed: 9813341] [MGI Ref ID J:51056]
Vogel MW; Sinclair M; Qiu D; Fan H. 2000. Purkinje cell fate in staggerer mutants: agenesis versus cell death. J Neurobiol 42(3):323-37. [PubMed: 10645972] [MGI Ref ID J:113250]
Yamazaki T; Yang XO; Chung Y; Fukunaga A; Nurieva R; Pappu B; Martin-Orozco N; Kang HS; Ma L; Panopoulos AD; Craig S; Watowich SS; Jetten AM; Tian Q; Dong C. 2008. CCR6 regulates the migration of inflammatory and regulatory T cells. J Immunol 181(12):8391-401. [PubMed: 19050256] [MGI Ref ID J:142071]
Yang XO; Nurieva R; Martinez GJ; Kang HS; Chung Y; Pappu BP; Shah B; Chang SH; Schluns KS; Watowich SS; Feng XH; Jetten AM; Dong C. 2008. Molecular antagonism and plasticity of regulatory and inflammatory T cell programs. Immunity 29(1):44-56. [PubMed: 18585065] [MGI Ref ID J:137851]
Yang XO; Pappu BP; Nurieva R; Akimzhanov A; Kang HS; Chung Y; Ma L; Shah B; Panopoulos AD; Schluns KS; Watowich SS; Tian Q; Jetten AM; Dong C. 2008. T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma. Immunity 28(1):29-39. [PubMed: 18164222] [MGI Ref ID J:131020]
Yoon CH. 1972. Developmental mechanism for changes in cerebellum of staggerer mouse, a neurological mutant of genetic origin. Neurology 22(7):743-54. [PubMed: 4673255] [MGI Ref ID J:5304]
Zanjani HS; Herrup K; Guastavino JM; Delhaye-Bouchaud N; Mariani J. 1994. Developmental studies of the inferior olivary nucleus in staggerer mutant mice. Brain Res Dev Brain Res 82(1-2):18-28. [PubMed: 7842506] [MGI Ref ID J:20982]
Zanjani HS; Mariani J; Delhaye-Bouchaud N; Herrup K. 1992. Neuronal cell loss in heterozygous staggerer mutant mice: a model for genetic contributions to the aging process. Brain Res Dev Brain Res 67(2):153-60. [PubMed: 1511513] [MGI Ref ID J:1431]
Zanjani HS; Mariani J; Herrup K. 1990. Cell loss in the inferior olive of the staggerer mutant mouse is an indirect effect of the gene. J Neurogenet 6(4):229-41. [PubMed: 2231177] [MGI Ref ID J:28468]
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Price (US dollars $) Cryorecovery Fee $1900.00 Cryopreserved Embryos $1600.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
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Price (US dollars $) Cryorecovery Fee $2470.00 Cryopreserved Embryos $2080.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
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