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- Description
- Phenotype
- Genes & alleles
- Genotyping
- Health & husbandry
- References
- Purchasing information
- Terms of Use
Description
The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.
Strain Information
Type Mutant Stock; Spontaneous Mutation; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Species laboratory mouse Generation N32p Development
The softcoat (soc) mutation arose spontaneously in the BALB/cJ inbred strain at The Jackson Laboratory in 1966. It was outcrossed to C57BL/6J and bred homozygote x homozygote for 5 generations. Then it was backcrossed to C57BL/6J to N4 followed by sibling inbreeding with forced heterozygosis to N4F7 before outcrossing to C3FeLe.B6-a. The homozygous F2 from this cross-intercross was then crossed to the B6C3Fe-a/a F1 hybrid and the strain was maintained by cross-intercross with this hybrid. In 1986 this strain was cryopreserved at generation F32 using embryos from the cross of B6C3Fe-a/a F1 females with homozygous softcoat males.
Related Strains
Strains carrying a allele
View Strains carrying a (104 strains)
Phenotype
Phenotype Information
assigned by genotype
The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.
soc/soc
BALB/cJ
- skin/coat/nails phenotype
- abnormal epidermal layer morphology (MGI Ref ID J:15247)
- abnormal at birth
- cells of stratum germinativum are abnormally flattened with more distinct cell boundaries
- thinning of epidermis and formation of the hair canals in the stratum at 6 or 7 days are delayed up to 5 days
- abnormal hair growth (MGI Ref ID J:15247)
- hair is thin and forms in small hair bulbs
- delayed hair appearance (MGI Ref ID J:15247)
- normal thinning of epidermis and formation of the hair canals in the stratum at 6 or 7 days is delayed up to 5 days
- abnormal hair texture (MGI Ref ID J:15247)
- hair has angora-like softness
- abnormal hair types (MGI Ref ID J:15247)
- all types are thin with occasional caliber irregularities
- disheveled coat (MGI Ref ID J:15247)
- small hair bulbs result in kinks and irregularities of hair shafts
This mouse can be used to support research in many areas including:soc related
Dermatology Research
Skin and Hair Texture Defects
Genes & Alleles
Gene & Allele Information
| Allele Symbol | a | ||
|---|---|---|---|
| Allele Name | nonagouti | ||
| Allele Type | Spontaneous | ||
| Allele Symbol | soc | ||
| Allele Name | soft coat | ||
| Allele Type | Spontaneous | ||
| Strain of Origin | BALB/cJ | ||
| Gene Symbol and Name | soc, soft coat | ||
| Chromosome | 3 | ||
Genotyping
Genotyping Information
This strain will not have a genotyping protocol or one is not currently available.
Helpful Links
Genotyping resources and troubleshooting
References
References
Additional References
soc relatedDickie MM. 1968. soc - soft coat Mouse News Lett 38:24. [MGI Ref ID J:64256]
Gruneberg H. 1971. Exocrine glands and the Chievitz organ of some mouse mutants. J Embryol Exp Morphol 25(2):247-61. [PubMed: 5088022] [MGI Ref ID J:140462]
Southard JL. 1971. Soft coat and hemimelic extra toes. Mouse News Lett 45:29. [MGI Ref ID J:13518]
Sundberg JP (ed.). 1994. . In: Handbook of Mouse Mutations with Skin and Hair Abnormalities: Animal Models and Biomedical Tools. CRC Press, Boca Raton. [MGI Ref ID J:30359]
Sundberg JP; Sundberg BA; Beamer WG. 1997. Comparison of chemical carcinogen skin tumor induction efficacy in inbred, mutant, and hybrid strains of mice: Morphologic variations of induced tumors and absence of a papillomavirus cocarcinogen. Mol Carcinog 20(1):19-32. [PubMed: 9328433] [MGI Ref ID J:43880]
Trigg MJ. 1972. Hair growth in mouse mutants affecting coat texture. J Zool 168:165-198. [MGI Ref ID J:15247]
Health & husbandry
Health & Colony Maintenance Information
Currently there no information available for this strain. This may be due to the supply level of this strain.
Purchasing information
Pricing, Supply Level & Notes, Controls, General Terms & Conditions
Pricing
| Pricing for USA, Canada and Mexico shipping destinations |
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Animals Provided
Price (US dollars $) Cryorecovery Fee $1900.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Additional Supply Details
| Pricing for International shipping destinations |
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Animals Provided
Price (US dollars $) Cryorecovery Fee $2470.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Additional Supply Details
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Supply Details
| Standard Supply | Cryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information. |
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| Supply Notes |
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Payment Terms and Conditions
Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.
See Terms of Use tab for General Terms and Conditions
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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JAX® Mice, Products & Services Conditions of Use
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