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Type Mutant Stock; Spontaneous Mutation; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Species laboratory mouse Generation N6F1 Description
Mice homozygous for the teetering spontaneous mutation (tn) die between 5 and 6 weeks of age. Homozygous mutant mice are first recognizable at 25 to 30 days by their stiff, slow, unstable movements and their growth retardation. They may assume and maintain unusual postures. Occasionally they have running "fits". Just prior to death they look emaciated and lie on their sides with all limbs extended. In the brainstem and spinal cord there is dysgenesis of selective regions including the pons, trapezoid body, olivary and fastigial nuclei, and the pyramidal tract. There is also progressive Purkinje cell loss.Development
The teetering mutation spontaneously arose in the C3H/HeJ inbred strain in 1959 at The Jackson Laboratory. The mutation was backcrossed to C57BL/6J six times and maintained as a sibling mating. In 1979, a high incidence of hydrocephalus in the colony prompted an outcross to B6C3FeF1/J a/a. This strain was cryopreserved as embryos in 1986.
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View Mammalian Phenotype Terms
Mammalian Phenotype Terms
assigned by genotype
The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.
tn/tn
C3H/HeJ
- life span-post-weaning/aging
- premature death (MGI Ref ID J:13411)
- just prior to death around 5 weeks of age, mice become emaciated and cannot stand or walk
- behavior/neurological phenotype
- abnormal motor coordination/ balance (MGI Ref ID J:5025)
- impaired balance (MGI Ref ID J:5025)
- impaired swimming (MGI Ref ID J:5025)
- jerky movement (MGI Ref ID J:5025)
- mice tend to lurch and launch forward
- abnormal posture (MGI Ref ID J:13411)
- hunched posture (MGI Ref ID J:5025)
- upright sitting position maintained with tail, and forelimbs and hindlimbs close to the chest
- abnormal stationary movement (MGI Ref ID J:13411)
- evident at 25 to 30 days of age when movements become stiff, slow, and unstable
- increased stereotypic behavior (MGI Ref ID J:5025)
- mice repeatedly run in "fits", attepmt to climb and fall over, with feet continuing to run
- opisthotonus (MGI Ref ID J:5025)
- growth/size phenotype
- decreased body size (MGI Ref ID J:13411)
- by 30 days of age growth retardation is evident
- muscle phenotype
- opisthotonus (MGI Ref ID J:5025)
- nervous system phenotype
- abnormal cerebellar cortex morphology (MGI Ref ID J:5025)
- fiber tracts and granular layer are reduced
- Purkinje cell degeneration (MGI Ref ID J:5025)
- there is progressive cell loss
- thin granule layer (MGI Ref ID J:5025)
- abnormal medulla oblongata (MGI Ref ID J:5025)
- smaller than that of normal mice
- small relative to size of forebrain and hindbrain of same mouse
- volume of both white and gray matter is reduced
- abnormal midbrain morphology (MGI Ref ID J:5025)
- midbrain is smaller compared to normal siblings
- abnormal spinal cord grey matter morphology (MGI Ref ID J:5025)
- cord is deficient in gray matter, with progressive severity toward the head
- abnormal spinal cord white matter morphology (MGI Ref ID J:5025)
- cord is deficient in white matter, with progressive severity toward the head
- decreased spinal cord size (MGI Ref ID J:5025)
- small cerebellum (MGI Ref ID J:5025)
- lobular formation and folia are normal; overall size is smaller
- volume of white and gray matter is reduced
View Research Applications
Research Applications
This mouse can be used to support research in many areas including:tn related
Developmental Biology Research
Neurodevelopmental Defects
Neurobiology Research
Neurodevelopmental Defects
| Allele Symbol | a | ||
|---|---|---|---|
| Allele Name | nonagouti | ||
| Allele Type | Spontaneous | ||
| Allele Symbol | tn | ||
| Allele Name | teetering | ||
| Allele Type | Spontaneous | ||
| Strain of Origin | C3H/HeJ | ||
| Gene Symbol and Name | tn, teetering | ||
| Chromosome | 11 | ||
This strain will not have a genotyping protocol or one is not currently available.
Helpful Links
Genotyping resources and troubleshooting
Meier H. 1967. The neuropathy of teetering, a neurological mutation in the mouse. Arch Neurol 16(1):59-66. [PubMed: 6024256] [MGI Ref ID J:5025]
tn relatedLane PW; Green MC. 1962. Teetering (tn) Mouse News Lett 27:38. [MGI Ref ID J:13411]
Meier H. 1967. The neuropathy of teetering, a neurological mutation in the mouse. Arch Neurol 16(1):59-66. [PubMed: 6024256] [MGI Ref ID J:5025]
Currently there no information available for this strain. This may be due to the supply level of this strain.
| Pricing for USA, Canada and Mexico shipping destinations |
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Animals Provided
Price (US dollars $) Cryorecovery Fee $1900.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
| Pricing for International shipping destinations |
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Animals Provided
Price (US dollars $) Cryorecovery Fee $2470.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
| Standard Supply | Cryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information. |
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| Supply Notes |
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Purchasing Information
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