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Description
The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.
Strain Information
Former Names B6CBACa-Aw-J/A-Kcnj6wv (Changed: 15-DEC-04 ) Type Mutant Strain; Spontaneous Mutation; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Species laboratory mouse Generation N31 Appearance
white-bellied agouti, ataxic
Related Genotype: Aw-J/? Kcnj6wv/Kncj6wv
agouti, ataxic
Related Genotype: A/A Kcnj6wv/Kncj6wv
white-bellied agouti, unaffected
Related Genotype: Aw-J/? +/? or Aw-J/A Kncj6wv/+
agouti, unaffected
Related Genotype: A/A +/? or A/A Kncj6wv/+Description
Mice homozygous for the weaver spontaneous mutation (Kcnj6wv) are recognizable in the second postnatal week by their small size, instability of gait, weakness, and hypotonia. Many homozygous mutant mice die at weaning age, but some survive to adulthood, and females may breed. The cerebellum in homozygous mutants is very small, simple, and almost devoid of granule cells, which degenerate during the second week. Heterozygotes behave normally, but they have a smaller than normal cerebellum with a deficiency of granule cells, some of which fail to migrate into the internal granule layer and remain scattered in the molecular layer. Evidence from cultures of mutant and normal cerebellum show that granule cells of Kcnj6wv/Kcnj6wv and Kcnj6wv/+ mice have gene-dosage dependent abnormalities in morphology and cell behavior. Studies using homozygous weaver/wildtype chimeras indicate that the migration defect of granule cells is intrinsic to the granule cells themselves. The disarrangement of Purkinje cells, however, is not caused by intrinsic action of weaver in these cells. Cell mixing experiments also suggest Kcnj6wv acts non-autonomously and encodes a membrane-associated ligand that induces external germinal layer neuron differentiation.Development
Weaver (Kcnj6wv) arose spontaneously in the pedigreed expansion stocks of C57BL/6J at The Jackson Laboratory in 1961. It was maintained by mating tested pairs until F21. Ovarian transplantation to C57BL/6J was used to F21N3 and then because of poor breeding performance a weaver (wv/wv) male was outcrossed to a CBA/Ca female and the tested offspring (wv/+) were mated to the B6CBACa hybrids. Backcrossing to the hybrid B6CBACa was then made each generation by mating a homozygous female weaver to a hybrid and mating the known heterozygotes. The stock was at N46 in 1992. It was cryopreserved in 1986 by mating heterozygous females to heterozygous males at N30-N32 or by mating homozygous females to B6CBACa F1 males.
Control Information
| Control | ||
|---|---|---|
| Untyped from the colony | ||
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying Aw-J allele
View Strains carrying Aw-J (31 strains)
Phenotype
Phenotype Information
assigned by genotype
Kcnj6wv/Kcnj6+
B6CBACa Aw-J/A-Kcnj6wv/J
- nervous system phenotype
- abnormal cerebellar Purkinje cell layer (MGI Ref ID J:72069)
- disruptions of Purkinje cell alignment are observed
- in more rostral regions of the central zone, Purkinje cells are ecctopic and have stunted and disorganized dendrites
- abnormal Purkinje cell morphology (MGI Ref ID J:72069)
- in the central zone, Purkinje cells located farther from the pial surface are clumped together in clusters
- abnormal Purkinje cell dendrite morphology (MGI Ref ID J:72069)
- in more rostral regions of the central zone, cells have stunted and have randomly organized dendrites
- delaminated Purkinje cell layer (MGI Ref ID J:72069)
- Purkinje cell layer is irregular and several cell layers thick, especially in the anterior zone of the cerebellar cortex
Kcnj6wv/Kcnj6+
B6CBA Aw-J/A-Kcnj6wv
- reproductive system phenotype
- abnormal male germ cell morphology (MGI Ref ID J:23163)
- in numerous cases, fragments of a few flagella are seen within the same cytoplasmic matrix
- abnormal spermatid morphology (MGI Ref ID J:23163)
- many step 2-3 spermatids often have 2 to 3 acrosomal vesicles associated with one nucleus
- mature spermatids are often absent in affected areas of the seminiferous tubules; multinucleated spermatids are common
- mature spermatids are deformed, maloriented and display irregular chromosomal condensation
- oligozoospermia (MGI Ref ID J:23163)
- sperm count in mutants is 7.1 x 105 compared to 127.7 x 105 in wild-type
- abnormal seminiferous epithelium morphology (MGI Ref ID J:23163)
- cellular abnormalities of the germinal epithelium are more apparent at P140 and P211; seminiferous epithelium has prominent extracellular spaces and local depletion of the epithelium
- abnormal sperm motility (MGI Ref ID J:23163)
- abnormal spermatogenesis (MGI Ref ID J:23163)
- abnormal spermatid morphology (MGI Ref ID J:23163)
- many step 2-3 spermatids often have 2 to 3 acrosomal vesicles associated with one nucleus
- mature spermatids are often absent in affected areas of the seminiferous tubules; multinucleated spermatids are common
- mature spermatids are deformed, maloriented and display irregular chromosomal condensation
- oligozoospermia (MGI Ref ID J:23163)
- sperm count in mutants is 7.1 x 105 compared to 127.7 x 105 in wild-type
- endocrine/exocrine gland phenotype
- abnormal seminiferous epithelium morphology (MGI Ref ID J:23163)
- cellular abnormalities of the germinal epithelium are more apparent at P140 and P211; seminiferous epithelium has prominent extracellular spaces and local depletion of the epithelium
Kcnj6wv/Kcnj6+
involves: C57BL/6 * CBA/CaGnLe
- nervous system phenotype
- abnormal cerebellum morphology (MGI Ref ID J:18348)
- in heterozygotes the cerebellum is slightly shrunken, and some folia is less well-developed than in wild-type
- abnormal cerebellar Purkinje cell layer (MGI Ref ID J:46842)
- heterozygotes display a disordered Purkinje cell layer
- abnormal cerebellar granule layer (MGI Ref ID J:46842)
- there is moderated loss of granule cells
- small cerebellum (MGI Ref ID J:46842)
- cerebellum is slightly smaller in heterozygotes; it is misshapen and deflated
Kcnj6wv/Kcnj6wv
B6CBACa Aw-J/A-Kcnj6wv/J
- growth/size phenotype
- decreased body weight (MGI Ref ID J:72069)
- homozygotes have decreased body weight compared to wild-type
- behavior/neurological phenotype
- abnormal locomotor activation (MGI Ref ID J:6717)
- when mutants are treated with direct dopamine agonists, they display a greater increase in locomotor activity than wild-type; amphetamine, which potentiates release of endogenous dopamine stores has less effect in mutants than in wild-type
- ataxia (MGI Ref ID J:72069)
- homozygotes are characterized by an ataxic gait
- nervous system phenotype
- abnormal nervous system morphology (MGI Ref ID J:6717)
- in mutants the dopamine system fails to form
- abnormal cerebellar cortex morphology (MGI Ref ID J:72069)
- in homozygotes, Purkinje cell ectopia in the nodular zone is less pronounced but the Purkinje cell layer is several layers thick
- abnormal cerebellar Purkinje cell layer (MGI Ref ID J:72069)
- abnormal cerebellar lobule formation (MGI Ref ID J:72069)
- in homozygotes, normal lobation is disrupted
- abnormal dopaminergic neuron morphology (MGI Ref ID J:6717)
- in mutants fewer large neurons are seen in the midbrain
- abnormal substantia nigra morphology (MGI Ref ID J:6717)
- in mutants the pars compacta and substantia nigra appear hypocellular compared to wild-type
- decreased dopamine level (MGI Ref ID J:6717)
- dopamine levels are decreased by 27% in the olfactory tubercle, 77% lower in the frontal cortex and 75% lower in the striatum in 6 month-old mutants compared to wild-type
- homeostasis/metabolism phenotype
- *normal* homeostasis/metabolism phenotype (MGI Ref ID J:29151)
- no aberrant bleeding time after tail vein nick
Kcnj6wv/Kcnj6wv
B6CBA Aw-J/A-Kcnj6wv
- reproductive system phenotype
- abnormal male germ cell morphology (MGI Ref ID J:23163)
- in numerous cases, fragments of a few flagella are seen within the same cytoplasmic matrix
- abnormal spermatid morphology (MGI Ref ID J:106298)
- spermatid nuclei often show irregular chromosomal condensation
- numerous multinucleated spermatids are present at P21
- globozoospermia (MGI Ref ID J:23163)
- at P56, numerous round spermatids are swollen, multinucleated, show defects in acrosomal structures and are undergoing degeneration
- oligozoospermia (MGI Ref ID J:23163)
- sperm count in mutants is 7.1 x 105 compared to 202.5 x 105 in wild-type
- abnormal seminiferous tubule morphology (MGI Ref ID J:23163)
- in P21 mutants, there is a lack of patent lumina
- abnormal Sertoli cell morphology (MGI Ref ID J:23163)
- at P21, mutants show Sertoli cells with slightly vacuolated cytoplasm
- at P56, defects in seminiferous tubule epithelium are often associated with shrinkage of the apical processes of Sertoli cells, their disconnection from the surface of germ cells and paucity of mature spermatids
- at P56, degenerating Sertoli cells of mutants are electron-dense, conspicuously shrunken, and have a foamy cytoplasmic appearance; many are round with small nuclei that have deeply folded surface configurations
- abnormal seminiferous epithelium morphology (MGI Ref ID J:23163)
- at P56 in mutants seminiferous epithelium displays progressive atrophic changes and many cellular aberrations
- abnormal sperm motility (MGI Ref ID J:23163)
- in mutants, percentage of mobile sperm is 23.8% compared to 73% in wild-type
- abnormal spermatogenesis (MGI Ref ID J:23163)
- in seminiferous tubules at P21, mutants have less advanced spermatid maturation and there are numerous multinucleated spermatids
- cytoplasmic processes are observed which incorporate parallel membranous structures that show connections to the cisternae and vesicles of the smooth endoplasmic reticulum
- abnormal spermatid morphology (MGI Ref ID J:106298)
- spermatid nuclei often show irregular chromosomal condensation
- numerous multinucleated spermatids are present at P21
- globozoospermia (MGI Ref ID J:23163)
- at P56, numerous round spermatids are swollen, multinucleated, show defects in acrosomal structures and are undergoing degeneration
- oligozoospermia (MGI Ref ID J:23163)
- sperm count in mutants is 7.1 x 105 compared to 202.5 x 105 in wild-type
- homeostasis/metabolism phenotype
- abnormal ion homeostasis (MGI Ref ID J:106298)
- resting Ca2+ levels are elevated in mutant cerebellar granule neurons compared to wild-type; high potassium stimulation evokes less [Ca2+] change in mutant cerebellar granule neurons than in wild-type
- endocrine/exocrine gland phenotype
- abnormal seminiferous tubule morphology (MGI Ref ID J:23163)
- in P21 mutants, there is a lack of patent lumina
- abnormal Sertoli cell morphology (MGI Ref ID J:23163)
- at P21, mutants show Sertoli cells with slightly vacuolated cytoplasm
- at P56, defects in seminiferous tubule epithelium are often associated with shrinkage of the apical processes of Sertoli cells, their disconnection from the surface of germ cells and paucity of mature spermatids
- at P56, degenerating Sertoli cells of mutants are electron-dense, conspicuously shrunken, and have a foamy cytoplasmic appearance; many are round with small nuclei that have deeply folded surface configurations
- abnormal seminiferous epithelium morphology (MGI Ref ID J:23163)
- at P56 in mutants seminiferous epithelium displays progressive atrophic changes and many cellular aberrations
Kcnj6wv/Kcnj6wv
involves: C57BL/6 * CBA/CaGnLe
- behavior/neurological phenotype
- ataxia (MGI Ref ID J:18348)
- homozygous mutants are distinguished by ataxia at 3 weeks of age
- at P10, homozygotes display ataxia, tremor and hindlimb weakness
- impaired righting response (MGI Ref ID J:18348)
- at 7 days of age, homozygotes are distinguished by difficulty in righting themselves
- tremors (MGI Ref ID J:18348)
- homozygous mutants are distinguished by tremors at 3 weeks of age
- walking backwards (MGI Ref ID J:18348)
- A 7 days of age, homozygotes display tendency to move backward
- muscle phenotype
- hypotonia (MGI Ref ID J:18348)
- homozygous mutants are distinguished by hypotonia at 3 weeks of age
- endocrine/exocrine gland phenotype
- abnormal testis morphology (MGI Ref ID J:18348)
- at P28, germ cells are underdeveloped or delayed; degeneration of germ cells in the semiferous epithelium is apparent and no tubules have late-step elongated spermatids and 6% of the tubules show degenerating seminiferous epithelia
- at P35, mutant males show only a small number of germ cells that have finished the first round of spermatogenesis
- abnormal seminiferous tubule morphology (MGI Ref ID J:18348)
- in homozygotes, the testes have few seminiferous tubules containing elongated spermatids
- seminiferous tubule degeneration (MGI Ref ID J:18348)
- testes of homozygotes show degenerating tubules with degenerating germ cells
- at P35, degeneration is much more severe than that observed at P28; degenerating germ cells are present in all mutants examined
- homozygotes display variable germinal epithelial degeneration
- nervous system phenotype
- abnormal cerebellar granule layer (MGI Ref ID J:46842)
- there is a marked depletion of granule cells in the internal granule cell layer
- abnormal cerebellar molecular layer (MGI Ref ID J:46842)
- there are ectopic granule cells found in the molecular layer
- abnormal external granule cell layer morphology (MGI Ref ID J:46842)
- numerous dying cells are seen compared to wild-type
- apoptotic cells lay mainly along the inner margin of the layer at P7 and 14; at P21 and 28, most apoptotic cells are confined to the thin external granule layer
- at P7, the normal organization of granule cells into a proliferative and a nonprolifeative zone is not maintained in homozygotes
- small cerebellum (MGI Ref ID J:18348)
- homozygotes have and abnormally small and malformed cerebellum
- at P7, the cerebellum of homozygotes is one-fifth the size of wild-type with a pronounced midline sulcus
- reproductive system phenotype
- abnormal epididymis morphology (MGI Ref ID J:18348)
- lumens of epididymes of mutants are either empty or packed with degenerating germ cells with pyknotic nuclei and cellular debris; there are no long sickle-shaped nuclei indicative of mature sperm
- abnormal testis morphology (MGI Ref ID J:18348)
- at P28, germ cells are underdeveloped or delayed; degeneration of germ cells in the semiferous epithelium is apparent and no tubules have late-step elongated spermatids and 6% of the tubules show degenerating seminiferous epithelia
- at P35, mutant males show only a small number of germ cells that have finished the first round of spermatogenesis
- abnormal seminiferous tubule morphology (MGI Ref ID J:18348)
- in homozygotes, the testes have few seminiferous tubules containing elongated spermatids
- seminiferous tubule degeneration (MGI Ref ID J:18348)
- testes of homozygotes show degenerating tubules with degenerating germ cells
- at P35, degeneration is much more severe than that observed at P28; degenerating germ cells are present in all mutants examined
- homozygotes display variable germinal epithelial degeneration
- azoospermia (MGI Ref ID J:18348)
- no sperm are found in seminiferous tubules of male homozygotes
- male infertility (MGI Ref ID J:18348)
- cellular phenotype
- increased apoptosis (MGI Ref ID J:46842)
- in homozygotes there are many more apoptotic germ cells than in wild-type
- at P7 and 14, there is much greater cell death in the cerebellum of homozygotes
Kcnj6wv/Kcnj6wv
involves: C57BL/6J * CBA
- nervous system phenotype
- abnormal hippocampal mossy fiber morphology (MGI Ref ID J:30108)
- mossy fibers emanating from the hilus of the dentate gyrus are not confined to the layers flanking the pyramidal cell layer
- abnormal hippocampus pyramidal cell layer (MGI Ref ID J:30108)
- in homozygous mutants the pyramidal cell layer of area CA3 appears to be thicker than normal
- subdivision of the pyramidal layer into 2 and 3 layers is seen in area CA3
- ectopic pyramidal neurons (MGI Ref ID J:30108)
- ectopic pyramidal cells are seen in the stratum radiatum and/or in the stratum oriens: these appear as small clusters or single cells surrounded by neuropil
The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.
Kcnj6wv/Kcnj6+
involves: C57BL/6J
- cellular phenotype
- abnormal cell migration (MGI Ref ID J:16025)
- prior to P4, granule cell migration is delayed
- increased apoptosis (MGI Ref ID J:16025)
- more pyknotic nuclei are observed in the external granule layer of heterozygotes at all times compared to wild-type
- nervous system phenotype
- abnormal cerebellum morphology (MGI Ref ID J:16025)
- cerebellar hemispheres in heterozygotes are 37% smaller than wild-type
- at P8, total width of the cerebellum is decreased by 13%
- abnormal cerebellar molecular layer (MGI Ref ID J:16025)
- in heterozygotes the molecular layer is thin and relative acellular at P4; at P6 the molecular layer appears to be hypercellular compared to wild-type
- in the cerebellar hemispheres, 40% fewer pyknotic nuclei are observed than in the vermis
- abnormal vermis morphology (MGI Ref ID J:16025)
- from P2 to P4, area of the vermis is 33% smaller in heterozygotes than in wild-type; by P8, the vermal area of mutants is 57% of the area of wild-type
- abnormal substantia nigra morphology (MGI Ref ID J:38206)
- substantial cell loss in the substantia nigra pars compacta of the midbrain
- behavior/neurological phenotype
- abnormal locomotor activity (MGI Ref ID J:38206)
- reproductive system phenotype
- male infertility (MGI Ref ID J:38206)
Kcnj6wv/Kcnj6wv
C57BL/6J-Kcnj6wv
- behavior/neurological phenotype
- abnormal motor capabilities/coordination/movement (MGI Ref ID J:13422)
- author states that behavior resembles that of Relnrl and Rorasg; no data is given
- life span-post-weaning/aging
- premature death (MGI Ref ID J:13422)
- most homozygous mutants do not live to maturity
- nervous system phenotype
- abnormal granule neuron (MGI Ref ID J:15542)
- granule cell neurons in the cerebellum have an unusually large number of coated vesicles throughout the length of the neurite in mutants
- microtubules in mutant granule cell neurites are less densely packed, curving and crossing along the neurite length and delimiting the neurite perimeter while in wild-type microtubules fill the internal dimensions of the neurite
- cytoskeletal organization of mutant granule cell neurons in mutants shows a denser cytoplasmic matrix, indistinct skeletal structure of the cytoplasm, and microtubules delineating the boundary of microspike-like projections and entering them
Kcnj6wv/Kcnj6wv
involves: C57BL/6J
- cellular phenotype
- abnormal cell migration (MGI Ref ID J:16025)
- prior to P4, granule cell migration is delayed
- increased apoptosis (MGI Ref ID J:16025)
- percentage of pyknotic nuclei in the granule layer in cerebella of homozygotes is dramatically increased compared to wild-type and heterozygotes; this is increased in the vermis relative to that of the cerebellar hemisphere
- nervous system phenotype
- abnormal cerebellum morphology (MGI Ref ID J:5315)
- cytoarchitecture of cerebellum is completely disorganized
- there is no clear distinction between cortical layers
- at P8, the area of the cerebellar hemispheres is reduced by 23% compared to wild-type
- at P8 the width of the cerebellum is reduced by 10 and 13% compared to heterozygotes and wild-type respectively
- abnormal cerebellar cortex morphology (MGI Ref ID J:5315)
- small caliber parallel fibers are virtually absent
- abnormal cerebellar Purkinje cell layer (MGI Ref ID J:5315)
- Purkinje cells display disordered arrangement
- abnormal Purkinje cell morphology (MGI Ref ID J:5315)
- Purkinje cells display disordered arrangement
- abnormal cerebellar granule layer (MGI Ref ID J:5315)
- there is a severe paucity of granule cells in homozygotes
- by P2 there is a decrease in the number of cells in the vermal external granule layer in homozygotes; the difference is mor striking at P4 and unlike wild-type or heterozygous mice, no spindle-shaped cells are observed
- abnormal cerebellar molecular layer (MGI Ref ID J:16025)
- the molecular layer is thin and relatively acellular from P0 to P6 compared to wild-type
- abnormal vermis morphology (MGI Ref ID J:16025)
- area of the vermis in homozygotes at P2 is 46% that of wild-type and 69% that of heterozygous mice; at P4, the vermis is 48% the size of wild-type
Kcnj6wv/Kcnj6wv
involves: C57BL/6
- nervous system phenotype
- abnormal CNS synaptic transmission (MGI Ref ID J:35792)
- abnormal granule neuron (MGI Ref ID J:35792)
- in cultured cerebellar granule cells, very little inwardly rectifying K+ current can be evoked with somatostatin or by direct activation of G proteins, compared to wild-type cells
Kcnj6wv/Kcnj6wv
C57BL/6J
- lethality-postnatal
- lethality at weaning (MGI Ref ID J:30520)
- majority die at about 3 weeks of age
- postnatal lethality (MGI Ref ID J:30520)
- behavior/neurological phenotype
- abnormal gait (MGI Ref ID J:30520)
- abnormal maternal nurturing (MGI Ref ID J:30520)
- abnormal motor coordination/ balance (MGI Ref ID J:30520)
- coordination is better in the second week of life than in the third week
- adult mice are unable to stand or step forward without falling over
- impaired righting response (MGI Ref ID J:30520)
- decreased eating behavior (MGI Ref ID J:30520)
- mutants nurse poorly
- induced hyperactivity (MGI Ref ID J:30520)
- unique to cerebellar mutants: mice may leap when excited or agitated despite being neurologically compromised
- tonic-clonic seizures (MGI Ref ID J:30520)
- tremors (MGI Ref ID J:30520)
- a fine, rapid tremor is seen in the trunk and extremities
- the mouse moving accentuates the tremor
- weaving (MGI Ref ID J:30520)
- growth/size phenotype
- decreased body size (MGI Ref ID J:30520)
- obvious 8 to 10 days after birth
- decreased body weight (MGI Ref ID J:30520)
- mutants weigh about 50 percent of control sibling weight until the second month when they reach control sibling weight
- life span-post-weaning/aging
- decreased survivor rate (MGI Ref ID J:30520)
- survivor rate is increased if normal foster mothers nurse pups
- premature death (MGI Ref ID J:30520)
- almost all mutants die within a year, whereas normal littermates live considerably longer
- nervous system phenotype
- abnormal cerebellar Purkinje cell layer (MGI Ref ID J:30520)
- during greatest mitotic activity, some granule cells are degenerating
- increased Purkinje cell number (MGI Ref ID J:30520)
- relative to the volume of cerebellar cortical tissue
- abnormal cerebellar granule layer (MGI Ref ID J:30520)
- almost complete absence of granule cells
- cells are restricted to the most lateral portions of the cerebellar hemisphere and paraflocculus
- abnormal cerebellar molecular layer (MGI Ref ID J:30520)
- during greatest mitotic activity, the majority of granule cells are degenerating
- abnormal cerebellum development (MGI Ref ID J:30520)
- abnormal external granule cell layer morphology (MGI Ref ID J:30520)
- extensive degeneration of external granule cells prior to migration to form granule layer
- absent cerebellar lobules (MGI Ref ID J:30520)
- absent cerebellum fissure (MGI Ref ID J:30520)
- small cerebellum (MGI Ref ID J:30520)
- abnormally small at 5 to 7 days and thereafter
- about one-fourth the size of normal in mature mice
- tonic-clonic seizures (MGI Ref ID J:30520)
- reproductive system phenotype
- reduced female fertility (MGI Ref ID J:30520)
- reduced male fertility (MGI Ref ID J:30520)
This mouse can be used to support research in many areas including:Kcnj6wv related
Cell Biology Research
Channel and Transporter Defects
potassium
Neurobiology Research
Ataxia (Movement) Defects
Cerebellar Defects
Channel and Transporter Defects
potassium
Epilepsy
Genes & Alleles
Gene & Allele Information
| Allele Symbol | Aw-J | ||
|---|---|---|---|
| Allele Name | white bellied agouti Jackson | ||
| Allele Type | Spontaneous | ||
| Common Name(s) | AWJ; | ||
| Strain of Origin | C57BL/6J | ||
| Gene Symbol and Name | a, nonagouti | ||
| Chromosome | 2 | ||
| Gene Common Name(s) | AGSW; AGTI; AGTIL; ASP; As; MGC126092; MGC126093; SHEP9; agouti; agouti signal protein; agouti suppressor; | ||
| Allele Symbol | Kcnj6wv | ||
| Allele Name | weaver | ||
| Allele Type | Spontaneous | ||
| Common Name(s) | wv; | ||
| Strain of Origin | C57BL/6J | ||
| Gene Symbol and Name | Kcnj6, potassium inwardly-rectifying channel, subfamily J, member 6 | ||
| Chromosome | 16 | ||
| Gene Common Name(s) | BIR1; GIRK2; KATP2; KCNJ7; KIR3.2; MGC126596; hiGIRK2; weaver; wv; | ||
| Molecular Note | A G-to-A transition at position 953 replaces a Gly with Ser at amino acid residue 156, affecting the highly conserved H5 domain of the channel. [MGI Ref ID J:29230] [MGI Ref ID J:30864] | ||
Genotyping
Genotyping Information
This strain will not have a genotyping protocol or one is not currently available.
Helpful Links
Genotyping resources and troubleshooting
References
References
Selected Reference(s)
Hirano A; Dembitzer HM. 1973. Cerebellar alterations in the weaver mouse. J Cell Biol 56(2):478-86. [PubMed: 4118891] [MGI Ref ID J:5315]
Yao W; Zhong J; Rosen CJ; Hock JM; Lee WH. 2005. Igf-I and postnatal growth of weaver mutant mice. Endocrine 26(2):117-25. [PubMed: 15888923] [MGI Ref ID J:109832]
Additional References
Douhou A; Debeir T; Michel PP; Stankovski L; Oueghlani-Bouslama L; Verney C; Raisman-Vozari R. 2003. Differential activation of astrocytes and microglia during post-natal development of dopaminergic neuronal death in the weaver mouse. Brain Res Dev Brain Res 145(1):9-17. [PubMed: 14519489] [MGI Ref ID J:86201]
Gao WQ; Liu XL; Hatten ME. 1992. The weaver gene encodes a nonautonomous signal for CNS neuronal differentiation. Cell 68(5):841-54. [PubMed: 1547486] [MGI Ref ID J:2009]
Guatteo E; Fusco FR; Giacomini P; Bernardi G; Mercuri NB. 2000. The weaver mutation reverses the function of dopamine and GABA in mouse dopaminergic neurons. J Neurosci 20(16):6013-20. [PubMed: 10934250] [MGI Ref ID J:63835]
Patil N; Cox DR; Bhat D; Faham M; Myers RM; Peterson AS. 1995. A potassium channel mutation in weaver mice implicates membrane excitability in granule cell differentiation [see comments] Nat Genet 11(2):126-9. [PubMed: 7550338] [MGI Ref ID J:29230]
Perandones C; Costanzo RV; Kowaljow V; Pivetta OH; Carminatti H; Radrizzani M. 2004. Correlation between synaptogenesis and the PTEN phosphatase expression in dendrites during postnatal brain development. Brain Res Mol Brain Res 128(1):8-19. [PubMed: 15337313] [MGI Ref ID J:92848]
Rotter A; Rath S; Evans JE; Frostholm A. 2000. Modulation of GABA(A) receptor subunit mRNA levels in olivocerebellar neurons of purkinje cell degeneration and weaver mutant mice. J Neurochem 74(5):2190-200. [PubMed: 10800965] [MGI Ref ID J:61537]
Aw-J relatedKcnj6wv relatedAberg T; Wang XP; Kim JH; Yamashiro T; Bei M; Rice R; Ryoo HM; Thesleff I. 2004. Runx2 mediates FGF signaling from epithelium to mesenchyme during tooth morphogenesis. Dev Biol 270(1):76-93. [PubMed: 15136142] [MGI Ref ID J:92174]
Barsh GS; Epstein CJ. 1989. Physical and genetic characterization of a 75-kilobase deletion associated with al, a recessive lethal allele at the mouse agouti locus. Genetics 121(4):811-8. [PubMed: 2566558] [MGI Ref ID J:9799]
Baurle J; Vogten H; Grusser-Cornehls U. 1998. Course and targets of the calbindin D-28k subpopulation of primary vestibular afferents. J Comp Neurol 402(1):111-28. [PubMed: 9831049] [MGI Ref ID J:118430]
Boran T; Lesot H; Peterka M; Peterkova R. 2005. Increased apoptosis during morphogenesis of the lower cheek teeth in tabby/EDA mice. J Dent Res 84(3):228-33. [PubMed: 15723861] [MGI Ref ID J:112546]
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Wei J; Dlouhy SR; Bayer S; Piva R; Verina T; Wang Y; Feng Y ; Dupree B ; Hodes ME ; Ghetti B. 1997. In situ hybridization analysis of Girk2 expression in the developing central nervous system in normal and weaver mice. J Neuropathol Exp Neurol 56(7):762-71. [PubMed: 9210872] [MGI Ref ID J:41890]
Wei J; Hodes ME; Piva R; Feng Y; Wang Y; Ghetti B; Dlouhy SR. 1998. Characterization of murine Girk2 transcript isoforms: structure and differential expression. Genomics 51(3):379-90. [PubMed: 9721208] [MGI Ref ID J:49749]
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Witt TC; Triarhou LC. 1995. Transplantation of mesencephalic cell suspensions from wild-type and heterozygous Weaver mice into the denervated striatum: assessing the role of graft-derived dopaminergic dendrites in the recovery of function. Cell Transplant 4(3):323-33. [PubMed: 7640872] [MGI Ref ID J:29105]
Womack M; Thompson K; Fanselow E; Augustine GJ; Peterson A. 1998. Elevated intracellular calcium levels in cerebellar granule neurons of weaver mice. Neuroreport 9(15):3391-5. [PubMed: 9855287] [MGI Ref ID J:52134]
Won L; Ghetti B; Heller B; Heller A. 1997. In vitro evidence that the reduction in mesencephalic dopaminergic neurons in the weaver heterozygote is not due to a failure in target cell interaction. Exp Brain Res 115(1):174-9. [PubMed: 9224846] [MGI Ref ID J:43336]
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Health & husbandry
Health & Colony Maintenance Information
Currently there no information available for this strain. This may be due to the supply level of this strain.
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Pricing
| Pricing for USA, Canada and Mexico shipping destinations |
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Animals Provided
Price (US dollars $) Cryorecovery Fee $1900.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Additional Supply Details
| Pricing for International shipping destinations |
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Animals Provided
Price (US dollars $) Cryorecovery Fee $2470.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Additional Supply Details
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Supply Details
| Standard Supply | Cryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information. |
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Control Information
| Control | ||
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| Untyped from the colony | ||
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| USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
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