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- Description
- Disease & phenotype
- Genes & alleles
- Genotyping
- Health & care
- References
- Pricing & purchasing
- Terms of use
Description
The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.
Strain Information
Type Spontaneous Mutation; Additional information on Genetically Engineered and Mutant Mice. Type Inbred Strain; Additional information on Inbred Strains. Visit our online Nomenclature tutorial. Species laboratory mouse Important Note
This strain is segregating for Tbx10Dc.Description
Mice heterozygous for the semidominant dancer mutation exhibit head tossing and circling behavior. Heterozygotes are not deaf, but have defects in the vestibular region (Wenngren et al., 1989). Homozygotes die at birth with cleft lip and cleft palate (Deol et al., 1966). Strain background influences cleft lip/palate expression in heterozygotes (Trasler et al., 1982). Positional cloning of Dc revealed a 3.3 kb insertion of the Tebp gene into the first intron of Tbx10. The insertion causes ectopic expression of a Tebp-Tbx10 chimeric transcript (Bush et al., 2004).Development
Dancer (Dc) arose as a spontaneous mutation in the C3H/He obese strain (C3H/He-Lepob) at N4 at The Jackson Laboratory in 1956. A dancer and normal sibling of the first appearing dancer mouse were mated and their dancer off spring (Dc/+) was crossed once to C3H/HeJ . The F1's of this cross were sibling mated with an unaffected (+/+) male that came from from the intercross of a dancer (Dc/+) male and an unaffected (+/+) female. The strain was then maintained in this manner and was cryopreserved by mating heterozygous males to +/+ females or vice versa at generation F124 in 1990, and later freezes in 2001 and 2004 were recovered from the original freeze.
Control Information
| Control | ||
|---|---|---|
| Wild-type from the colony | ||
| Considerations for Choosing Controls | ||
Related Strains
Facebase: models
View Facebase: models (58 strains)
Phenotype
Phenotype Information
assigned by genotype
Tbx10Dc/Tbx10Dc
DC/LeJ
- craniofacial phenotype
- cleft lip
- bilateral cleft lip evident at embryonic day 16.5 (MGI Ref ID J:89946)
- cleft secondary palate
- accompanies cleft lip and evident at embryonic day 16.5 (MGI Ref ID J:89946)
- failure of palatal shelf elevation
- at E16.5, palatal shelves fail to elevate (MGI Ref ID J:89946)
- digestive/alimentary phenotype
- cleft secondary palate
- accompanies cleft lip and evident at embryonic day 16.5 (MGI Ref ID J:89946)
- failure of palatal shelf elevation
- at E16.5, palatal shelves fail to elevate (MGI Ref ID J:89946)
- vision/eye phenotype
- delayed eyelid fusion (MGI Ref ID J:89946)
- eyelids open at birth
- in some homozygotes (MGI Ref ID J:89946)
The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.
Tbx10Dc/Tbx10+
involves: C3H/HeJ
- nervous system phenotype
- abnormal vestibular nerve morphology
- the superior vestibular nerve enters the saccular macula near the center of the macula, rather than the dorsal border (MGI Ref ID J:5022)
- along with the utricular macula, the utricular branch of the superior vestibular nerve is entirely missing (MGI Ref ID J:5022)
- the pathway of the nerve from the superior vestibular ganglion to the crista rarely takes a normal course along the base of the utricle, but often passes through the otic capsule and tympanic cavity, and is often branched (MGI Ref ID J:5022)
- the lateral vestibular nerve rarely follows a normal course, and the nerve is very thin in instances when the crista is small (MGI Ref ID J:5022)
- small vestibular ganglion
- the vestibular ganglion does not extend much beyond the superior border of the saccular macula and has fewer, less densely packed cells (MGI Ref ID J:5022)
- vestibular ganglion hypoplasia (MGI Ref ID J:5022)
- hearing/vestibular/ear phenotype
- *normal* hearing/vestibular/ear phenotype
- heterozygotes are not deaf, the cochlea appears normal (MGI Ref ID J:5022)
- abnormal bony labyrinth (MGI Ref ID J:5022)
- abnormal ear development
- by embryonic day 10 the acoustic ganglion is smaller and does not curve around to reach the anterior aspect of the vesicle, and the epithelium on the antero-lateral aspect is not thickened as in normal embryos (MGI Ref ID J:5022)
- by embryonic day 11 the nerve that would normally innervate the epithelium destined to become the utricular macula and superior lateral cristae is deficient and aberrent or entirely lacking (MGI Ref ID J:5022)
- by embryonic day 12 the utriculo-saccular folds are abnormal in appearance, the utricular nerve is always missing, the nerves of the superior and lateral cristae are sometimes missing, and the accessory nerve from the superior vestibular ganglion sometimes branches to one of the critae and is always thinner than normal (MGI Ref ID J:5022)
- by embryonic day 13 the shape and size of the utricle and saccule are abnormal, the utricle has no nerve supply and no macula, the nerves of the superior and lateral semicircular ducts are often missing, and the utriculo-saccular fold is thicker than normal, slants in the medial direction, and is foreshortened posteriorly (MGI Ref ID J:5022)
- by embryonic day 16 the absence of the utricular valve and saccular duct is evident (MGI Ref ID J:5022)
- abnormal inner ear vestibule morphology (MGI Ref ID J:5022)
- abnormal semicircular canal morphology (MGI Ref ID J:5022)
- abnormal lateral semicircular canal morphology
- the majority of heterozygotes have a unilateral or bilateral severe narrowing, complete obliteration of the lumen, or absence of the ampullar end of the lateral semicircular duct and constriction or absence of the bony canal in this region (MGI Ref ID J:5022)
- this abnormality is more severe in the lateral than the superior semicircular canal (MGI Ref ID J:5022)
- abnormal semicircular canal ampulla morphology (MGI Ref ID J:5022)
- abnormal crista ampullaris morphology
- when narrowing is found in the superior semicircular duct, the crista is either missing or poorly formed, and even when normal in appearance the crista is often shifted in its location (MGI Ref ID J:5022)
- abnormal superior semicircular canal morphology
- the majority of heterozygotes have a unilateral or bilateral severe narrowing or complete obliteration of the lumen of the ampullar end of the superior semicircular duct and constriction of the bony canal in this region (MGI Ref ID J:5022)
- abnormal vestibular labyrinth morphology (MGI Ref ID J:5022)
- behavior/neurological phenotype
- abnormal gait
- by 2 weeks of age heterozygotes decelop a weaving gait with bi-directional circling (MGI Ref ID J:5022)
- abnormal postural reflex
- when lifted by the tail at approximately 3 days of age a heterozygote will hump its back instead of arching it, retract the front legs and bend the head toward the belly (MGI Ref ID J:5022)
- when lifted by the tail as an adult, a heterozygote will twist and turn and throw its body about (MGI Ref ID J:5022)
- circling
- similar circling behavior as that of waltzer mutants but with less head movement (MGI Ref ID J:24773)
- bidirectional circling (MGI Ref ID J:5022)
- head tilt
- some, but not all, may hold their heads tilted to the side (MGI Ref ID J:5022)
- head tossing
- heterozygotes make jerking movements of the head in both horizontal and vertical planes (MGI Ref ID J:5022)
- hyperactivity
- evident by 1 week of age and increasing by 2 weeks of age (MGI Ref ID J:5022)
- impaired swimming (MGI Ref ID J:24773)
- growth/size phenotype
- decreased body size
- smaller than wild-type littermates by 1 week of age (MGI Ref ID J:5022)
- pigmentation phenotype
- head spot
- most dancer mutants have a white spot, varying in size, in the middle of the head (MGI Ref ID J:5022)
- craniofacial phenotype
- cleft palate
- does not occur spontaneously but can be induced on this background by treatment of pregnant mothers with 6-aminonicotinamide (MGI Ref ID J:7364)
- digestive/alimentary phenotype
- cleft palate
- does not occur spontaneously but can be induced on this background by treatment of pregnant mothers with 6-aminonicotinamide (MGI Ref ID J:7364)
- integument phenotype
- head spot
- most dancer mutants have a white spot, varying in size, in the middle of the head (MGI Ref ID J:5022)
Tbx10Dc/Tbx10Dc
involves: C3H/HeJ
- mortality/aging
- complete neonatal lethality
- homozyogtes die within a few hours of birth and 9 of 40 newborns from heterozygous intercrosses have this inviable phenotype (MGI Ref ID J:5022)
- craniofacial phenotype
- cleft lip
- unilateral or bilateral cleft lip (MGI Ref ID J:5022)
- cleft palate (MGI Ref ID J:5022)
- digestive/alimentary phenotype
- cleft palate (MGI Ref ID J:5022)
This mouse can be used to support research in many areas including:Tbx10Dc related
Dermatology Research
Color and White Spotting Defects
Developmental Biology Research
Craniofacial and Palate Defects
cleft palate and cleft lip
Neurodevelopmental Defects
Neurobiology Research
Hearing Defects
Neurodevelopmental Defects
Sensorineural Research
Hearing Defects
Genes & Alleles
Gene & Allele Information provided by MGI
| Allele Symbol | Tbx10Dc | ||
|---|---|---|---|
| Allele Name | dancer | ||
| Allele Type | Spontaneous | ||
| Common Name(s) | Dc; | ||
| Strain of Origin | C3H/J-Lep | ||
| Gene Symbol and Name | Tbx10, T-box 10 | ||
| Chromosome | 19 | ||
| Gene Common Name(s) | Dc; T-box 13; TBX13; TBX7; Tbx13; dancer; | ||
| Molecular Note | The mutation in this allele comprises a small translocation insertion that placed a 3.3 kb fragment of Chr 10 into intron 1 of the Tbx10 gene. This inserted sequence includes exon 1 of the Tebp gene. RT-PCR analysis of Tbx10 expression revealed that the full-length trancript is expressed normally in mutant mice, and that a chimeric transcript consisting of the Tebp exon 1 of the inserted sequence fused in-frame to exon 2 of the Tbx10 gene is expressed ectopically. This chimeric transcript is predictedto encode a trucated, but functional protein that is similar to a normal variant. [MGI Ref ID J:89946] | ||
References
References provided by MGI
Additional References
Deol MS; Lane PW. 1966. A new gene affecting the morphogenesis of the vestibular part of the inner ear in the mouse. J Embryol Exp Morphol 16(3):543-58. [PubMed: 5297683] [MGI Ref ID J:5022]
Saridaki A; Ferraz C; Demaille J; Scherer G; Roux AF. 2000. Genomic sequencing reveals the structure of the Kcnk6 and map3k11 genes and their close vicinity to the sipa1 gene on mouse chromosome 19. Cytogenet Cell Genet 89(1-2):85-8. [PubMed: 10894943] [MGI Ref ID J:63233]
Trasler DG; Kemp D; Trasler TA. 1984. Increased susceptibility to 6-aminonicotinamide-induced cleft lip of heterozygote Dancer mice. Teratology 29(1):101-4. [PubMed: 6230750] [MGI Ref ID J:7364]
Trasler DG; Leong S. 1982. Mitotic index in mouse embryos with 6-aminonicotinamide-induced and inherited cleft lip. Teratology 25(2):259-65. [PubMed: 7101202] [MGI Ref ID J:6819]
Tbx10Dc relatedAbbott C; FitzPatrick DR; McLaren L. 2003. Mapping of the Dancer mutation on Chromosome 19 MGI Direct Data Submission :. [MGI Ref ID J:86481]
Bush JO; Lan Y; Jiang R. 2004. The cleft lip and palate defects in Dancer mutant mice result from gain of function of the Tbx10 gene. Proc Natl Acad Sci U S A 101(18):7022-7. [PubMed: 15118109] [MGI Ref ID J:89946]
Deol MS. 1976. Deficiencies of the inner ear in the mouse and their origin Colloq Int (Collques Internationaux) C.N.R.S. 266:163-171. [MGI Ref ID J:136112]
Deol MS; Lane PW. 1966. A new gene affecting the morphogenesis of the vestibular part of the inner ear in the mouse. J Embryol Exp Morphol 16(3):543-58. [PubMed: 5297683] [MGI Ref ID J:5022]
Jacobson D; Trasler DG. 1992. Morphometric analysis of heterozygote dancer mice predisposed to 6-aminonicotinamide-induced cleft lip. Teratology 45(4):393-400. [PubMed: 1585267] [MGI Ref ID J:1602]
Lane PW. 1958. New mutants: Dancer, Athetoid, and mahogany Mouse News Lett 19:25. [MGI Ref ID J:24773]
Trasler DG; Kemp D; Trasler TA. 1984. Increased susceptibility to 6-aminonicotinamide-induced cleft lip of heterozygote Dancer mice. Teratology 29(1):101-4. [PubMed: 6230750] [MGI Ref ID J:7364]
Trasler DG; Leong S. 1982. Mitotic index in mouse embryos with 6-aminonicotinamide-induced and inherited cleft lip. Teratology 25(2):259-65. [PubMed: 7101202] [MGI Ref ID J:6819]
Wenngren BI; Anniko M. 1990. Aberrant frequency tuning and early stereociliary derangement in genetic inner ear disease. Acta Otolaryngol 109(3-4):202-12. [PubMed: 2316343] [MGI Ref ID J:90425]
Wenngren BI; Anniko M. 1988. Age-related auditory brainstem response (ABR) threshold changes in the dancer mouse mutant. Acta Otolaryngol 106(5-6):386-92. [PubMed: 3207006] [MGI Ref ID J:90423]
Wenngren BI; Anniko M. 1989. Vestibular hair cell pathology in the dancer mouse mutant. Acta Otolaryngol 107(3-4):182-90. [PubMed: 2784612] [MGI Ref ID J:90424]
Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.
Pricing and Purchasing
Pricing, Supply Level & Notes, Controls
| Pricing for USA, Canada and Mexico shipping destinations |
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Cryopreserved
Cryopreserved Mice - Ready for Recovery
Animals Provided
Price (US dollars $) Cryorecovery* $2250.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Standard Supply
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.
Supply Notes
- Cryorecovery - Standard.
Progeny testing is not required.
The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 11 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).
| Pricing for International shipping destinations |
|
Cryopreserved
Cryopreserved Mice - Ready for Recovery
Animals Provided
Price (US dollars $) Cryorecovery* $2925.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Standard Supply
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.
Supply Notes
- Cryorecovery - Standard.
Progeny testing is not required.
The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 11 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).
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Standard Supply
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.
General Supply Notes
- Genomic DNA is available for this strain from the Mouse DNA Resource.
Control Information
| Control | ||
|---|---|---|
| Wild-type from the colony | ||
| Considerations for Choosing Controls | ||
| Control Pricing Information for Genetically Engineered Mutant Strains. | ||
Important Note
This strain is segregating for Tbx10Dc.
Payment Terms and Conditions
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering Information
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